NEUES VERFAHREN ZUR HERSTELLUNG VON EPOTHILONE-DERIVATEN

ARYL TERPENE ETHERS

... 1362007 Aryl terpene ethers CIBA-GEIGY AG 19 Oct 1971 [20 Oct 1970 23 Aug 1971] 48626/71 Heading C2C Novel compounds of Formula I wherein Z 1 and Z 2 are together an additional C-C bond or together an oxygen bridge; R 1 and R 2 independently are each methyl or ethyl; and R 3 is alkyl carbonyl or alkylcarbamoyl having up to 5 C atoms, carbamoyl or phenylcarbamoyl, may be prepared by (i) reacting the appropriate phenol with a suitable hydrocarbon halide; or (ii) by transforming a 6,7-unsaturated compound to the 6,7 epoxy derivative with an epoxidizing agent; or (iii) converting a 6,7- unsaturated compound with N-bromosuccinimide into the 6,7 bromohydrin compound which is then converted to a 6,7-epoxy compound by treatment with an alkaline agent. The novel compounds may be used as pest control agents.

TERPENE ARYL ETHER

... 1356560 Terpene aryl ethers CIBA-GEIGY AG 19 Oct 1971 [20 Oct 1970 23 Aug 1971] 35460/73 Divided out of 1355575 Heading C2C The invention comprises compounds of the formula wherein R 1 and R 2 represent a CH 3 or C 2 H 5 group, and either (i) Z 1 and Z 2 together represent an additional bond or an oxygen bridge, while Z 3 and Z 4 together represent an additional bond, or they each represent H atoms, or (ii) Z 1 , Z 2 Z 3 and Z 4 all represent H atoms. They may be obtained by (1) reacting a halide of the formula wherein X is a halogen atom, with 4-propargyloxyphenol, in the presence of an acid-binding agent; (2) reacting a compound of the formula with a compound of the formula in the presence of an acid-binding agent; or (3) when Z 1 and Z 2 together represent an oxygen bridge, reacting the corresponding compound in which Z 1 and Z 2 together represent an additional bond with an epoxidizing agent in the presence of an inert solvent. Examples are given for the preparation of the compounds ...

2-HYDROXY-3-(SUBSTITUTED ARYL)-3-BUTENOIC ACID ESTERS AND THEIR PRODUCTION

Terpenic alcohol ethers arylic and their application to the fight against insects and Arachnida.

New ethers and produced pesticides which contain some.

INSECTICIDE MEANS

Insecticide means

Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof

The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.

PROCESS FOR PRODUCING CARBOXYLIC ACID COMPOUND

A process for producing a carboxylic acid compound, the process being shown by scheme (I).

A NEW PROCESS FOR THE PREPARATION OF EPOTHILONE DERIVATIVES, NEW EPOTHILONE DERIVATIVES AS WELL AS NEW INTERMEDIATE PRODUCTS FOR THE PROCESS AND THE METHODS OF PREPARING SAME

The present invention provides a synthesis for the preparation of epothilone derivatives of formula (9) wherein R1 is methyl, and R2 has the meaning of an unsubstituted or substituted aryl, an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus, and salts thereof, and intermediates for the synthesis of a compound of formula (9).

FUNGICIDAL ALKYL-SUBSTITUTED 2-[2-CHLORO-4-(4-CHLORO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS

The present invention relates to the use of alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi and seed coated with at least one such compound. The invention also relates to novel alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound.

ANTIFUNGAL AGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND INTERMEDIATES

A compound represented by the general formula: (see formula 1) wherein R1 and R2 denote a halogen atom or hydrogen atom; R3 means a hydrogen atom or lower alkyl group; ~ , r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

Aryl ethers of terpene alcohols - insecticides acaricides, anthelmintics

Terpene aryl ethers of the formula:- (where Z1 and Z2 = H or together a second C-C bond or oxygen bridge; R1 and R2 = (1-4C) alkyl. When Z3 and Z4 = C-C bond, R3 = (2-4C) alkenyl, (2-4C) haloalkenyl, (2-4C) alkenyloxy, (2-4C) alkenyloxy, (2-4C) haloalkenyloxy, (2-5C) alkynyl, (25-C) alkynyloxy, (2-5C) haloakynyloxy, (3-6C) cycloalkyl, aryl, arylcarbonyl, aryloxy, aralkyl, aralkyloxy, aralkyl aralkyloxy, alkythiocarbonyl, (2-4C) alkenyloxycarbonyl, (2-5C) alkynyloxycarbonyl, alkoxycarbonylalkyl, OH, carbamoyloxy, opt. substd. by one or two lower alkyl, -C=N-aryl, 1,3-dioxolan-2-yl, 1,3-dithiolan-2-yl, 1,3-oxathiolan-2-yl, 3-alkoxycarbonylal-1-en-l-yl, or -NR5R6, R5 and R6 = H, (1-4C) alkyl, (2-4C) alkenyl, (2-5C) alkynyl or R5 = H or (1-4C) alkyl and R6 = carbamoyl opt. substd. by one or two lower alkyl, acyl or aryl, R4 = H or (2-4C) alkenyloxy (2-5C) alkynyloxy or (2-5C) alkynyloxy carbonyl or R3 = H or (1-4C) alkyl or (1-4C) alkoxy and R4 (2-4C) alkenyloxy or (2-5C) alkynyloxy or R3 = ...

Terpenyl aryl ethers - parasiticides, esp insecticides acaricides, nematocides

Novel compds. are of formula (I) where Z1, Z2 are each H or together form a C-C bond or an oxygen bridge, R1 and R2 = Me or Et and (a) Z3 and Z4 together form a C-C bond, R3 = H or R and R4 = R, or R3 = R and R4 = H or R, or (b) Z3 and Z4 are each H and R3 and R4 = H or R; R being 2-5C alkylcarbonyl, carbamoyl, mono-1-4C-alkylcarbamoyl 2-4C alkenyl-carbamoyl or arylcarbamoyl. (I) are useful in combatting animal and vegetable parasites esp. insects, acarids and nematodes parasitic on plants. (I) prevent development of the parasites, are practically non-toxic to mmals and decompose rapidly hence their accumulation is impossible.

SCHAEDLINGSBEKAEMPFUNGSMITTEL.

БИОСОВМЕСТИМЫЕ И БИОРАЗЛАГАЕМЫЕ КОНЪЮГАТЫ АНАЛОГОВ ФУМАГИЛЛИНА

Предложены конъюгаты аналогов фумагиллина с полимерами, способы получения конъюгатов аналогов фумагиллина с полимерами, композиции, содержащие конъюгат аналога фумагиллина с полимером, и способы лечения рака или лечения ангиогенного заболевания, включающие введение субъекту эффективного количества конъюгата аналога фумагиллина с полимером. Также описаны новые аналоги фумагиллина, способы получения аналогов фумагиллина и способы лечения рака или лечения ангиогенного заболевания, включающие введение субъекту, нуждающемуся в этом, эффективного количества аналога фумагиллина.

БИОСОВМЕСТИМЫЕ И БИОРАЗЛАГАЕМЫЕ КОНЪЮГАТЫ АНАЛОГОВ ФУМАГИЛЛИНА

Предложены конъюгаты аналогов фумагиллина с полимерами, способы получения конъюгатов аналогов фумагиллина с полимерами, композиции, содержащие конъюгат аналога фумагиллина с полимером, и способы лечения рака или лечения ангиогенного заболевания, включающие введение субъекту эффективного количества конъюгата аналога фумагиллина с полимером. Также описаны новые аналоги фумагиллина, способы получения аналогов фумагиллина и способы лечения рака или лечения ангиогенного заболевания, включающие введение субъекту, нуждающемуся в этом, эффективного количества аналога фумагиллина.

PLANE SOLAR COLLECTOR HAS DOUBLE CIRCUIT OF FLUIDS

ácidos 4-((fenoxialquila)tio)-fenoxiacéticos e análogos e composição farmacêutica compreendendo-os

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

POLYMERIZABLE COMPOUND, OPTICAL RECORDING COMPOSITION, HOLOGRAPHIC RECORDING MEDIUM AND INFORMATION-RECORDING METHOD

PROBLEM TO BE SOLVED: To provide a polymerizable compound which is suitable for producing holographic recording media having high record reproduction accuracy. SOLUTION: The polymerizable compound is represented by general formula (1) [wherein, A is an oxygen atom; X is H, a polymerizable group or the like; Y and Z are each independently a halogen, a polymerizable group, or the like; B and C are each independently H, a halogen atom, a polymerizable group, or the like; at least one of B and C is H; at least one of X, Y and Z is a polymerizable group; (m) is an integer in a range of 0 to 5; (n) is an integer in a range of 0 to 2]. COPYRIGHT: (C)2008,JPO&INPIT ...

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ЭПОТИЛОНА

FIELD: chemistry. SUBSTANCE: method ensures carrying out aldole condensation in presence of epoxide mesilate and tosilate, using auxiliary chiral sultamic group as carboxyl- protecting group, as a result, reduction and oxidation stages, requiring extra time, before carrying out final stage of macrolactonisation are excluded. Introduction of epoxidic group at early stages of method allows also excluding stage of epoxilation of more complex intermediate compounds at further stages of process. EFFECT: high reproducibility of synthesis of highly-purified epothilone derivatives. 8 cl, 6 ex

СОЕДИНЕНИЯ АЗОЛА, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ ПРОТИВОГРИБКОВОЙ АКТИВНОСТЬЮ

FIELD: organic chemistry, fungicides, pharmacy. SUBSTANCE: invention describes new azole compounds of the general formula (I) where values A, R 1 -R 3 , W, X, Y, Z, m are given in the p. 1 of the invention claim and can be used for treatment of patients with dermatomycosis, visceromycosis. Invention describes also a method of their synthesis, intermediate compounds and the pharmaceutical composition showing an antifungal activity. EFFECT: improved method of synthesis, enhanced effectiveness of compositions. 31 cl, 6 tbl, 165 ex ДУбСУГС ПЧ Го (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (51) МПК ВИ” 2142 947 Сл С 070 233/60, 249/08, 417/06, 417/14, 409/06, 413/06, 409/14, 403/10, 513/04, А 61 К ЗЛ/АЛ, А 01 М 43/653 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 95101828/04, 06.02.1995 (24) Дата начала действия патента: 06.02.1995 (30) Приоритет: 07.02.1994 /Р 33268/94 05.07.1994 УР 174894194 10.08.1994 УР 208203/94 09.12.1994 УР 306467/04 (46) Дата публикации: 20.12.1999 (56) Ссылки: ЗИ 1251802 АЗ, 1986. ЕР 0044605 АЛ, 1982. ОЕ 2920314 05$, 1984. ЕР 0047594 А2, 1982. (98) Адрес для переписки: 129010, Москва, ул.Б.Спасская 25, стр.3, ООО "Городисский и Партнеры" (71) Заявитель: Эйсай Ко., Лтд. (Р) (72) Изобретатель: Тосихико Наито (.Р), Кацура Хата (}Р), Юмико Каку ()Р), Акихико Цуруока (Р), Итару Цукада (Р), Манабу Янагисава (/Р), Тосио Тойосава (.Р), Казумаса Нара (.Р) (73) Патентообладатель: Эйсай Ко., Лтд. (Р) (54) СОЕДИНЕНИЯ АЗОЛА, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ОБЛАДАЮЩАЯ ПРОТИВОГРИБКОВОЙ АКТИВНОСТЬЮ (57) Реферат: Описываются новые соединения азола общей формулы 1, где значения А, В! - ВЗ, \/, Х, У, 2, т указаны в п.1 формулы, которые проявляют противогрибковую активность и могут быть использованы при лечении дерматомикоза, висцеромикоза. Описывается также способ их получения, промежуточные соединения, а также фармацевтическая композиция, обладающая ...

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ЭПОТИЛОНА, НОВЫЕ ПРОИЗВОДНЫЕ ЭПОТИЛОНА, А ТАКЖЕ НОВЫЕ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ РЕАЛИЗАЦИИ СПОСОБА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

1. Соединения формулы 9 ! ! где R1 означает метил, a R2 означает незамещенный или замещенный арил, и соли с катионами металлов. ! 2. Соединения формулы 9 ! ! где R1 означает метил, a R2 означает незамещенный или замещенный фенил, и соли с катионами металлов. ! 3. Соединения формулы 3 ! ! где R2 имеет значения, указанные при определении формулы 9. ! 4. Способ получения соединений формулы 3, отличающийся тем, что соединение формулы 1, ! где R2 имеет значения, указанные выше, а мезилгруппа во всех последующих реакциях заменена тозилом и подобной группой, взаимодействует с сультам-производным формулы 2 во всех последующих стадиях реакции, например, ! ! в реакции селективной альдольной конденсации в присутствии кислоты Льюиса и при добавлении основания в инертном растворителе при пониженной температуре от -50°С до -100°С, а затем при повышенной температуре от -20°С до 20°С, с образованием соединения формулы 3. ! 5. Соединения формулы 4 ! ! где R2 имеет значения, указанные выше. ! 6. Способ получения соединений формулы 4, отличающийся тем, что соединение формулы 3 ! ! взаимодействует с соединением, образующим простой силиловый эфир, при температуре от -70°С до 25°С в присутствии 2,6-лутидина с образованием вышеуказанного соединения формулы 4. ! 7. Соединения формулы 5 ! ! где R2 имеет значения, указанные выше. ! 8. Способ получения новых соединений формулы 5, отличающийся тем, что в соединениях формулы 4 ! ! обработкой ТВАОН/Н2О2 в ДМЭ или LiO2H в ТГФ/МеОН/Н2О отщепляют хиральную вспомогательную группу с образованием карбоновой кислоты, т.е. соединения формулы 5. ! 9. Соединения формулы 6 ! ! где R2 имеет значения, указанные выше. ! 10. Способ получения новых соединений формулы 6, о�

EPOXY CONNECTION AND PROCEDURE FOR YOUR PRODUCTION

4 ((PHENOXYALKYL) THIO) - PHENOXYESSIGSÄUREN AND ANALOGUES

ETHERS

PHENALENE-1-ONE-CONTAINING PHOTOSENSITIZER COMPOSITION, PHENALENE-1-ONE COMPOUND AND WELL AS ITS USE

The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.

4-((ФЕНОКСИАЛКИЛ)ТИО)ФЕНОКСИУКСУСНЫЕ КИСЛОТЫ И АНАЛОГИ

Изобретение относится к 4-((феноксиалкил)тио)феноксиуксусным кислотам и аналогам, включающим их композициям и способам их применения в качестве модуляторов PPAR-дельта для лечения или ингибирования прогрессирования, например, дислипидемии.

FUNGICIDAL ALKYL-SUBSTITUTED 2-[2-CHLORO-4-(4-CHLORO-PHENOXY)-PHENYL]-1-[1,2,4]TRIAZOL-1-YL-ETHANOL COMPOUNDS

ЭПОКСИДНОЕ СОЕДИНЕНИЕ, СПОСОБ ЕГО ПОЛУЧЕНИЯ И СПОСОБ ПОЛУЧЕНИЯ СОЕДИНЕНИЯ ОКСАЗОЛА

Данное изобретение касается промежуточного соединения для получения 2,3-дигидроимидазо[2,1-b]оксазола с высоким выходом и высокой чистотой и способа получения промежуточного соединения. Данное изобретение представляет эпоксидное соединение, представленное общей формулой (2): , (2) где R1 - водород или низшая алкильна группа; и R2 - пиперидильная группа, представленная общей формулой (А1): (А1) (где R3 - феноксигруппа с галогензамещенной низшей алкоксигруппой, замещенной в фенильной группе, и т.п.) и т.п.; и n - целое число от 1 до 6, способ получения эпоксидного соединения и способ получения соединения оксазола с применением эпоксидного соединения.

4-((ФЕНОКСИАЛКИЛ)ТИО)ФЕНОКСИУКСУСНАЯ КИСЛОТА И ЕЕ АНАЛОГИ

Изобретение раскрывает 4-((феноксиалкил)тио)феноксиуксусные кислоты и их аналоги, композиции, которые их содержат, и способы их использования, как PPAR-дельта модуляторов, для лечения или ингибирования развития, например, дислипидемии.

Process for producing carboxylic acid compound

Fungicidal alkyl substituted 2 - [2-chloro-4 - (4-chlorophenoxy) phenyl] - 1 - [1, 2, 4] triazol-1-yl alcohol compounds

本发明涉及如说明书所定义的式I的烷基取代的2-[2-氯-4-(4-氯苯氧基)苯基]-1-[1,2,4]三唑-1-基乙醇化合物及其N-氧化物和盐在防治有害真菌中的用途以及涂有至少一种该类化合物的种子。本发明还涉及新的烷基取代的2-[2-氯-4-(4-氯苯氧基)苯基]-1-[1,2,4]三唑-1-基乙醇化合物、制备这些化合物的方法和中间体以及包含至少一种该类化合物的组合物。

COMPOSE MACROMONOMERES, THEIR PREPARATION FROM COMPOSE DIENIQUES AND THEIR USE

REACTION PRODUCTS OF AMINO ACIDS AND EPOXIES

Reaction products of one or more amino acids and one or more epoxies are included in copper and copper alloy electroplating baths to provide good throwing power. Such reaction products can plate an article with copper and copper alloys with good surface properties and good physical reliability. COPYRIGHT KIPO 2016 ...

ETHERS AND NOVEL PESTICIDAL PRODUCTS WHICH IN

DERIVATIVE OF EPICHLOROHYDRIN OF NATURAL ORIGIN

Derivative of epichlorohydrin of natural origin, selected from the group consisting of glycidyl ethers presenting an epoxide equivalent weight higher than or equal to 50 g/equivalent and lower than or equal to 15000 g/equivalent, of glycidyl esters, of glycidyl amides, of glycidyl imides, of glycidyl amines, and of any mixture thereof, and of which the 14 C mass content is such that the ratio 14 C / 12 C is higher than 0.7 10 -12 .

METHODS OF TREATING AGE RELATED DISORDERS

The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor. 1. A method of treating an oxidative stress disorder in a patient in need thereof , comprising administering to said patient an therapeutically effective amount of a MetAP2 inhibitor.2. The method of claim 1 , wherein the oxidative stress disorder is selected from the group consisting of Alzheimer's disease or an age-related disorder.3. The method of claim 2 , wherein age-related disorder is osteoarthritis claim 2 , sarcopenia or frailty.4. A method of treating memory impairment in a patient in need thereof comprising administering to said patient an therapeutically effective amount of a MetAP2 inhibitor.5. The method of claim 4 , wherein the memory impairment is due to Alzheimer's disease claim 4 , senile dementia claim 4 , mild cognitive impairment due to aging claim 4 , schizophrenia claim 4 , Parkinson's disease claim 4 , Huntington's disease claim 4 , Pick's disease claim 4 , Creutzfeldt-Jakob disease claim 4 , depression claim 4 , aging claim 4 , stroke claim 4 , CNS hypoxia claim 4 , cerebral senility claim 4 , cardiovascular disease claim 4 , head trauma or age-related cognitive decline.6. The method according to claim 4 , wherein said patient is suffering from memory impairment due to dementia.7. A method of enhancing cognitive function in a patient claim 4 , comprising administering to said patient an effective amount of a MetAP2 inhibitor.8. A method of treating an age-related disorder in a patient in need thereof claim 4 , comprising administering an effective amount of a MetAP2 inhibitor compound to the patient claim 4 , wherein said compound claim 4 , upon ...

HIGH HEAT MONOMERS AND METHODS OF USE THEREOF

High purity epoxide compounds methods for preparing the high purity epoxide compounds, and compositions derived from the epoxide compounds are provided. Also provided are materials and articles derived from the epoxide compounds.

Biocompatible biodegradable fumagillin analog conjugates

NEW ETHERS

A NEW PROCESS FOR THE PREPARATION OF EPOTHILONE DERIVATIVES, NEW EPOTHILONE DERIVATIVES AS WELL AS NEW INTERMEDIATE PRODUCTS FOR THE PROCESS AND THE METHODS OF PREPARING SAME

The present invention provides a synthesis for the preparation of epothilone derivatives of formula (9) wherein R1 is methyl, and R2 has the meaning of an unsubstituted or substituted aryl, an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus, and salts thereof, and intermediates for the synthesis of a compound of formula (9).

BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

PLANE SOLAR COLLECTOR HAS DOUBLE CIRCUIT OF FLUIDS

ARYL TERPENE ETHERS

Method for producing epoxy resin

Derivatives of certain geranyl phenyl ethers and their use in controlling insects

Compounds having the formula см. иллюстрацию в PDF-документе In which R is hydrogen, lower alkyl, lower alkenyl, lower alkoxy, halogen, nitro; or lower alkylthio; X is chlorine or bromine; A and B are each hydrogen, together form an epoxide link or together form a bond; the use of these compounds in controlling insects; and a method of preparing these compounds.

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

MATERIAL FOR FORMING FILM FOR LITHOGRAPHY, COMPOSITION FOR FORMING FILM FOR LITHOGRAPHY, FILM FOR LITHOGRAPHY, PATTERN FORMING METHOD AND PURIFICATION METHOD

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): 2. The material for forming the film for lithography according to claim 1 , wherein at least one p is an integer of 1 to 4.3. The material for forming the film for lithography according to claim 1 , wherein at least one Rrepresents the monovalent group having the oxygen atom.7. The resin according to claim 6 , wherein at least one p is an integer of 1 to 4.8. The resin according to claim 6 , wherein at least one Rrepresents the monovalent group having the oxygen atom.9. The resin according to claim 6 , wherein the compound having crosslinking reactivity is an aldehyde claim 6 , a ketone claim 6 , a carboxylic acid claim 6 , a carboxylic acid halide claim 6 , a halogen-containing compound claim 6 , an amino compound claim 6 , an imino compound claim 6 , an isocyanate claim 6 , or an unsaturated hydrocarbon group-containing compound.10. The resin according to claim 6 , which is at least one selected from the group consisting of a novolac-based resin claim 6 , an aralkyl-based resin claim 6 , a hydroxystyrene-based resin claim 6 , a (meth)acrylic acid-based resin and copolymers thereof.13. A material for forming a film for lithography claim 6 , comprising the resin according to .14. A composition for forming a film for lithography claim 6 , comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the material for forming the film for lithography according to , and'}an organic solvent.15. The composition for forming the film for lithography according to claim 14 , further comprising an acid generating agent.16. The composition for forming the film for lithography according to claim 14 , further comprising a crosslinking agent.17. A film for lithography claim 14 , formed using the composition for forming the film for lithography according to .18. A resist pattern forming method claim 14 , comprising{'claim-ref': {'@idref': ' ...

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ЭПОТИЛОНА, НОВЫЕ ПРОИЗВОДНЫЕ ЭПОТИЛОНА, А ТАКЖЕ НОВЫЕ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ РЕАЛИЗАЦИИ СПОСОБА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel epothilone derivatives of formula (8) , to synthesis method thereof and use thereof to obtain compounds of formula (9) , as well as to novel intermediate compounds for realising said method and synthesis methods thereof. The abbreviation P in said general structural formulae denotes a protective group of a functional hydroxyl selected from silyl protective groups, R2 denotes a 5-member heteroaryl containing N and S as heteroatoms, optionally substituted with C1-C6 alkyl, and R1 denotes methyl. ^ EFFECT: method of obtaining novel epothilone derivatives is simpler and better, can be well implemented on an industrial scale owing to a shorter synthesis path, and provides high reproducibility of synthesis of highly pure key intermediate compounds and end products. ^ 21 cl, 6 ex

НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ ЭПОТИЛОНА, НОВЫЕ ПРОИЗВОДНЫЕ ЭПОТИЛОНА, А ТАКЖЕ НОВЫЕ ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ РЕАЛИЗАЦИИ СПОСОБА И МЕТОДЫ ИХ ПОЛУЧЕНИЯ

... 1. Способ получения производных эпотилона формулы 9 где R1 означает метил, a R2 означает незамещенный или замещенный арил, незамещенный или замещенный гетероарил или незамещенный или замещенный гетероциклический радикал, конденсированный с бензольным циклом, и их солей с катионами металлов, причем способ, отличающийся тем, что а) взаимодействие соединения формулы 1 где R2 имеет значения, указанные выше, а мезилгруппа заменена тозилгруппой или подобной группой, а Р означает ОН-защитную группу, с сультам-производным формулы 2, например, по реакции селективной альдольной конденсации в присутствии кислоты Льюиса и при добавлении основания в инертном растворителе при пониженной температуре от -50 до -100°С, а затем при повышенной температуре от -20 до +20° С, с образованием соединения формулы 3 где R2 и Р имеют значения, указанные выше, и б) взаимодействие полученных соединений вышеуказанной формулы 3 с соединением, образующим простой силиловый эфир, при температуре от -70 до 25°С в присутствии ...

Organic compounds

NEW PROCEDURE FOR THE PRODUCTION OF EPOTHILONE ONES DERIVATIVES

Process for producing carboxylic acid compound

A process for producing a carboxylic acid compound, the process being shown by scheme (I).

EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound.

EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound.

PROCESS FOR THE MANUFACTURE OF EPOXY COMPOUNDS

Process for the manufacture of epoxy compounds of formula (D) wherein Rb represents a group selected from those of the formulae (1, 2 and 3) by reaction of a compound (A) or (B) with an alkylene oxide, in the presence of a catalyst, selected from the group of compounds containing at least one cation (C) in combination with a counter anion X- selected from halogen, acetate, phosphate or carboxylate or combinations thereof; manufacturing process for epoxy resins comprising at least the hereinbefore specified reaction step, and epoxy resins obtainable by said process, characterized by lower halogen content.

Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

Terpene aryl esters

New terpene aryl ethers of the formula см. иллюстрацию в PDF-документе wherein Z1 and Z2 together form a carbon-carbon-bond or together are an oxygen bridge, R1 and R2 are each methyl or ethyl, Z3 and Z4 together form a carbon-carbon-bond or are each hydrogen or Z1, z2, z3 and Z4 are all hydrogen and their use for combating insects are disclosed.

ЭПОКСИСОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

FIELD: chemistry. SUBSTANCE: present invention relates to a novel intermediate epoxy compound of general formula (2), where R 1 represents hydrogen or a lower alkyl group; and R 2 represents a piperidinyl group of general formula (A1), where R 3 represents a phenoxy group, having a halogen-substituted lower alkoxy group, substituted with a phenyl group, and other similar groups; and n is an integer from 1 to 6, to obtain 2,3-dihydroimidazo[2,1-b]oxazole. The invention also relates to specific epoxy compounds, a method of producing epoxy compounds of formula (2) and a method of producing 2,3-dihydroimidazo[2,1-b]-oxazole using a novel intermediate epoxy compound. EFFECT: obtaining 2,3-dihydroimidazo[2,1-b]oxazole with high output and high purity. 4 cl, 30 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 459 822 (13) C2 (51) МПК C07D 405/12 C07D 498/04 C07D 303/18 (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (72) Автор(ы): ЦУБОУТИ Хидецугу (JP), (24) Дата начала отсчета срока действия патента: ХАРАГУТИ Йосиказу (JP), 07.05.2008 ХАЯКАВА Сатоси (JP), УЦУМИ Наото (JP), Приоритет(ы): ТАИРА Синити (JP), (30) Конвенционный приоритет: ТАНАДА Йосихиса (JP), 08.05.2007 JP 2007-123097 ФУДЗИТА Нобухиса (JP), (43) Дата публикации заявки: 20.06.2011 Бюл. № 17 СИНХАМА Коити (JP), АННАКА Кимийоси (JP), (45) Опубликовано: 27.08.2012 Бюл. № 24 ФУРУТА Такуя (JP) 2 4 5 9 8 2 2 R U C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.12.2009 (86) Заявка PCT: JP 2008/058798 (07.05.2008) (87) Публикация заявки РСТ: WO 2008/140090 (20.11.2008) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", Е.Е.Назиной (54) ЭПОКСИСОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ группу, представленную общей формулой (А1), где R 3 представляет феноксигруппу, имеющую галогензамещенную низшую алкоксигруппу, замещенную на фенильной группе, и другие подобные группы; и n представляет ...

ФЕНАЛЕН-1-ОН-СОДЕРЖАЩАЯ КОМПОЗИЦИЯ ФОТОСЕНСИБИЛИЗАТОРА, ФЕНАЛЕН-1-ОНОВОЕ СОЕДИНЕНИЕ И ИХ ПРИМЕНЕНИЕ

A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Novel autophagy-targeting chimera (AUTOTAC) compound, and composition for preventing, alleviating, or treating diseases through target protein degradation comprising same

The present invention relates to: an autophagy-targeting chimera (AUTOTAC) compound in which a novel p62 ligand and a target-binding ligand are linked by means of a linker, or a stereoisomer, solvate, hydrate, or prodrug of the AUTOTAC compound; and a pharmaceutical or food composition for preventing or treating diseases through target protein degradation comprising same as an active ingredient. The present invention not only allows a concentration adjustment with a specific protein targeted, but also allows delivery of drugs and other low molecular weight compounds to lysosomes. The AUTOTAC compound according to the present invention selectively removes specific proteins and thus can be usefully employed as a pharmaceutical composition for preventing, alleviating, or treating various diseases.

Antifungal agents, processes for the preparation thereof, and intermediates

ETHERS

Fluorinated aryl epoxide compounds

A fluorinated aromatic epoxy compound having a fluorinated ether tail and a pendant epoxy functional group. These compounds are particularly useful as starting materials for producing various water and oil repellents and soil resists.

Insect hormone mimics

Compounds are described having the formula WHERE R is: ...

Process for preparing a 2-methyl-(substituted aryl)-pyruvic acid compound

A process for preparing 3-methyl-3-(substituted aryl)-pyruvic acid compounds by treating a glycidic acid ester compound of the formula, wherein R1 is a 4-biphenylyl, 4-clyclohexylphenyl, 3-phenoxyphenyl, 4'-fluoro-4-biphenylyl, 2-fluoro-4-biphenylyl or 3-benzoylphenyl group and R2 is a lower alkyl group or its corresponding free acid with a Lewis acid to form a 2-hydroxy-3-(substituted aryl)-3-butenoic acid ester and treating the resulting ester in an alcohol with an alkali metal alcoholate to form the pyruvic acid compounds. If desired, the pyruvic acid compounds can then be saponified to compounds of the formula, wherein R1 is as previously defined and which compounds are useful as anti-inflammatory agents.

ПРОТИВОГРИБКОВЫЕ АГЕНТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ, ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

Соединение общей формулы, представленной в описании, или его соль и его промежуточные соединения или их соли, а также способы их получения и фармацевтическая композиция для применения в качестве противогрибкового агента.

ЭПОКСИСОЕДИНЕНИЕ И СПОСОБ ЕГО ПОЛУЧЕНИЯ

1. Эпоксисоединение или его соль, представленное общей формулой (2): ! ! где R1 представляет водород или низшую алкильную группу; ! R2 представляет пиперидильную группу, представленную общей формулой (A1): ! ! где R3 представляет: ! (A1a) феноксигруппу, имеющую галогензамещенную низшую алкоксигруппу (группы) в качестве заместителя (заместителей) на фенильной группе, ! (A1b) феноксизамещенную низшую алкильную группу, имеющую галогензамещенную низшую алкильную группу (группы) в качестве заместителя (заместителей) на фенильной группе, ! (A1c) фенилзамещенную низший алкокси низшую алкильную группу, имеющую атом галогена (атомы галогена) в качестве заместителя (заместителей) на фенильной группе, ! (A1d) фенилзамещенную низшую алкильную группу, имеющую галогензамещенную низшую алкоксигруппу (группы) в качестве заместителя (заместителей) на фенильной группе, ! (A1e) аминогруппу, имеющую фенильную группу, имеющую галогензамещенную низшую алкоксигруппу (группы) в качестве заместителя (заместителей) на фенильной группе и низшую алкильную группу, или ! (A1f) фенилзамещенную низшую алкоксигруппу, имеющую галогензамещенную низшую алкоксигруппу (группы) в качестве заместителя (заместителей) на фенильной группе, или пиперазильную группу, представленную общей формулой (A2): ! ! где R4 представляет: ! (A2a) фенилзамещенную низшую алкенильную группу, имеющую галогензамещенную низшую алкоксигруппу (группы) в качестве заместителя (заместителей) на фенильной группе, или ! (A2b) галогензамещенную фенильную группу; и ! n представляет целое число от 1 до 6. ! 2. Эпоксисоединение или его соли, выбранное из группы, состоящей из: !1) (R)-1-[4-(2,3-эпокси-2-метилпропо РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2009 145 273 (13) A (51) МПК C07D 407/12 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2009145273/04, 07.05.2008 (71) Заявитель(и): ОЦУКА ФАРМАСЬЮТИКАЛ КО., ЛТД. (JP) Приоритет(ы): (30) Конвенционный ...

Antifungal agents, processes for the preparation thereof, and intermediates

Epoxy compound and method for manufacturing the same

PROCESS FOR REDUCING THE CONTENT OF HYDROLYSABLE CHLORINE IN GLYCIDYL COMPOUNDS

Process for reducing the content of hydrolysable chlorine in glycidyl compounds Abstract To reduce the content of hydrolysable chlorine in glycidyl compounds, these are dissolved in a halogen-free organic solvent and treated with an equivalent excess of aqueous alkali metal hydroxide solution at elevated tem-perature, the excess being 100 to 200%; of the equivalent amount theoretically required for complete dehydrochlorina-tion of the hydrolysable chlorine, the water is then removed from the organic solution, the organic solution is treated with 5 to 500 times the amount, based on the amount of alkali metal hydroxide employed, of moist cellulose containing up to 35% by weight of water at elevated temperature and, after filtration, the glycidyl compound is isolated from the organic solution.

4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

COMPOSTO EPÓXI OU UM SAL DO MESMO, E, MÉTODOS PARA A FABRICAÇÃO DE UM COMPOSTOS EPÓXI OU SAL DO MESMO E DE UM COMPOSTOS OXAZOL OU UM SAL DO MESMO.

Reaction products of amino acids and epoxies

Epoxy compound and method for manufacturing the same

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents a hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy method.

METHODS OF TREATING AGE RELATED DISORDERS

The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor. 1. A method of treating an age-related disorder in a patient in need thereof , comprising administering an effective amount of a MetAP2 inhibitor , wherein the age-related disorder is decreased physical endurance.2. The method of claim 1 , wherein said MetAP2 inhibitor is an irreversible MetAP2 inhibitor.3. The method of claim 1 , wherein said therapeutically effective amount does not substantially modulate or suppress angiogenesis.4. The method of claim 2 , wherein the MetAP2 inhibitor is selected from the group consisting of fumagillin claim 2 , fumigillol and fumigillol ester.6. The method of claim 1 , wherein said MetAP2 inhibitor is administered parenterally or non-parenterally.7. The method of claim 1 , wherein the patient is an adult human.8. The method of claim 7 , wherein the patient is 45 years or older.9. The method of claim 1 , wherein the patient also suffers from decreased neuromuscular coordination.10. The method of claim 8 , wherein the patient also suffers a disorder selected from diabetes claim 8 , peripheral vascular disease claim 8 , uremia claim 8 , ischemic stroke claim 8 , and combinations thereof.11. The method of claim 1 , wherein the patient also suffers a disorder selected from diabetes claim 1 , peripheral vascular disease claim 1 , uremia claim 1 , ischemic stroke claim 1 , and combinations thereof.12. A method of improving exercise capacity in a subject in need thereof claim 1 , comprising administering a therapeutically effective amount of a disclosed compound to the subject.13. The method of claim 12 , wherein the MetAP2 inhibitor is selected from ...

METHODS OF TREATING AGE RELATED DISORDERS

The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor. 1. A method of treating an age-related neuromuscular disorder in a patient in need thereof , comprising administering to the patient an effective amount of an irreversible MetAP2 inhibitor that covalently binds to MetAP2 , wherein said inhibitor , upon administration increases the level of metabolic products formed in the citric acid cycle and does not substantially increase alphaketoglutarate in the liver of said patient.2. The method of claim 1 , wherein said patient exhibits a reduction in expression of mCLK1.3. The method of claim 1 , wherein the patient claim 1 , upon administration of the MetAP2 inhibitor claim 1 , exhibits a decrease in non-mitochondrial oxidative damage.4. The method of claim 1 , wherein the patient claim 1 , upon administration of the MetAP2 inhibitor claim 1 , exhibits increased mitochondrial oxidative stress.5. The method of claim 1 , wherein said therapeutically effective amount does not substantially modulate or suppress angiogenesis.6. The method of claim 1 , further comprising administration of the MetAP2 inhibitor until a marker level is returned to a normal range.7. The method of claim 6 , wherein the marker is C-reactive protein.8. The method of claim 1 , wherein said MetAP2 inhibitor is administered parenterally or non-parenterally.9. The method of claim 1 , wherein the MetAP2 inhibitor is a fumagillin analog.10. The method of claim 9 , wherein the MetAP2 inhibitor is administered at a dose of about 0.01 mg/kg to about 10 mg/kg.11. The method of claim 9 , wherein the MetAP2 inhibitor is administered at a dose of about 0.04 mg/kg to about 1.0 mg/ ...

NOVEL TRIAZOLE DERIVATIVES

The present invention relates to novel triazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. 5. Method for controlling harmful microorganisms in crop protection and in the protection of one or more materials claim 1 , a compound of the formula (I) and/or a salt and/or N-oxide thereof according to to the harmful microorganisms and/or a habitat thereof.6. Method for controlling phytopathogenic harmful fungi claim 1 , comprising applying a compound of the formula (I) and/or a salt and/or N-oxide thereof according to the phytopathogenic harmful fungi and/or a habitat thereof.7. Composition for controlling harmful microorganisms in crop protection and in the protection of one or more materials claim 1 , optionally for controlling phytopathogenic harmful fungi claim 1 , comprising a content of at least one compound of the formula (I) and/or a salt and/or N-oxide thereof according to claim 1 , in addition to one or more extenders and/or surfactants.8. Composition according to comprising at least one further active ingredient selected from the group consisting of insecticides claim 7 , attractants claim 7 , sterilants claim 7 , bactericides claim 7 , acaricides claim 7 , nematicides claim 7 , fungicides claim 7 , growth regulators claim 7 , herbicides claim 7 , fertilizers claim 7 , safeners and semiochemicals.9. A product comprising a compound of the formula (I) and/or a salt and/or N-oxide thereof according to for control of harmful microorganisms claim 1 , optionally phytopathogenic harmful fungi claim 1 , for crop protection and/or for protection of one or more materials.10. Process for producing compositions for controlling harmful microorganisms claim 1 , optionally for controlling phytopathogenic harmful fungi claim 1 , ...

PHENALENE-1-ONE-CONTAINING PHOTOSENSITIZER COMPOSITION, PHENALENE-1-ONE COMPOUND AND THE USE THEREOF

A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

DERIVATIVE OF EPICHLOROHYDRIN OF NATURAL ORIGIN

Biocompatible biodegradable fumagillin analog conjugates

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

NEW ETHERS

ANTIFUNGAL AGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND INTERMEDIATES

A compound represented by the general formula: (I) wherein R1 and R2 denote a halogen atom or hydrogen atom; R3 means a hydrogen atom or lower alkyl group; ? , r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for -S-, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.

4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

... ²²The invention features 4-(phenoxyalykyl)thio)-phenoxyacetic acids and ²analogs, compositions containing them, and methods of using them as PPAR ²delta modulators to treat or inhibit the progression of, for example, ²dyslipidemia. More particularly, there is disclosed a compound of Formula (l):²(see formula I)²wherein X is a covalent bond, S, or O; Y is S or O; Z is O or CH2, provided ²when Y is O, then Z is O, R1 and R2 are independently H, C1-3 alkyl, C1-3 ²alkoxy, halo, or NR a R b, wherein R a and R b are independently H or C1-3 ²alkyl; R3 and R4 are independently H, halo, cyano, C1-5 alkyl, hydroxy,C2-4 ²acyl, C1-4 alkoxy, or NR c R d wherein R c and R d are independently H or C1-3 ²²alkyl, provided that R3 and R4 are not both H; R5 and R6 are independently ²halo, phenyl, C1-9 alkyl, C1-8 alkoxy, C2-9 alkenyl, C2-9 alkenyloxy, C3-7 ²cycloalkyl, C3-7 cycloalkoxy, C3-7cycloalkyl-C1-7alkyl, C3-7cycloalkyl-C1-7²alkoxy, C3-7cycloalkyloxy-C1-8alkyl, or C3-7cycloalkyloxy-C1-7alkoxy, or R5 ...

COMPOSE MACROMONOMERES, THEIR PREPARATION FROM COMPOSE DIENIQUES AND THEIR USE

La présente invention a pour objet des composés macromonomères (I): (CF DESSIN DANS BOPI) dans laquelle: - R**1 représente l'hydrogène, un halogène, un radical alkyle, aryle, alkylaryle ou arylalkyle, éventuellement substitué, - R**2 et R**3, identiques ou différents, représentent l'hydrogène, un halogène, un radical alkyle, aryle, alkylaryle ou arylalkyle, - R**4 représente un radical alkyle, aryle, alkylaryle ou arylalkyle, éventuellement substitué, ou -XR**5, avec R**5 représentant l'hydrogène, un radical alkyle, aryle, alkylaryle ou arylalkyle, éventuellement substitué, - X représente l'oxygène ou le soufre, - A correspond à une unité issue d'au moins un monomère à insaturation éthylénique, et - n est compris entre 1 et 10000. L'invention concerne aussi des composés diéniques (II): H2 C=CR**1-CH=CH-C(R**2)(R**3)- X2 -R**6 dans laquelle R**1, R**2, R**3 et X ont la même signification que précédemment et R**6 représente R**5 ou un groupe -COR**7 ou -COOR**7 avec R**7 étant un alkyle, ...

A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Beta-blocking chloropractolol and salts - for treatment of cardiac arrhythmias, angina, hypertension and post infarction patients

METHOD FOR PRODUCING COMPOUND USEFUL FOR SYNTHETIC INTERMEDIATE FOR PRODUCING AZOLE ANTIFUNGAL AGENT

PURPOSE: Provided is a method for producing a compound useful for a synthetic intermediate for producing an azole antifungal agent used in the prevention and treatment of various fungal infection diseases. CONSTITUTION: The compound as a synthetic intermediate for an azole antifungal agent is represented by the following formula(27). The compound of formula(27) is obtained by the method comprising the steps of: reacting a compound represented by formula(12) or a salt thereof with chloromethyl lithium produced from chloroiodomethane or bromochloromethane, or with dimethyl-sulfoxonium methylide, diethyl-sulfoxonium methylide or diethylsulfonium methylide to form a compound of formula(13) or a salt thereof: reacting the compound of formula(13) or a salt thereof with 1,2,4-triazole or imidazole or a salt thereof to form a compound of formula(21) or a salt thereof; and removing the hydroxyl-protecting group Pr from the compound of formula(21) or a salt thereof. In the above formulae, R is methyl ...

COMPOSED EPOXI AND METHOD TO PRODUCE THE SAME

Reivindicacion 1: Un compuesto epoxi o una sal del mismo, caracterizado por la formula general (2) donde R1 representa hidrogeno o un grupo alquilo inferior; R2 representa un grupo piperidilo representado por la formula general (A1) (donde R3 representa: (A1a) un grupo fenoxi que tiene grupo(s) alcoxi inferiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo, (A1b) un grupo alquilo interior sustituido con fenoxi que tiene grupo(s) alquilo interiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo, (A1c) un grupo alcoxi inferior alquilo inferior sustituido con fenilo que tiene halogeno(s) como sustituyente(s) sobre un grupo fenilo, (A1d) un grupo alquilo inferior sustituido con fenilo que tiene grupo(s) alcoxi inferiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo, (A1e) un grupo amino que tiene un grupo fenilo que tiene grupo(s) alcoxi inferiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo, y un grupo alquilo inferior, o (A1f) un grupo alcoxi inferior sustituido con fenilo que tiene grupo(s) alcoxi inferiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo), o un grupo piperazilo representado por la formula general (A2) (donde a4 representa: (A2a) un grupo alquenilo inferior sustituido con fenilo que tiene grupo(s) alcoxi inferiores sustituidos con halogeno como sustituyente(s) sobre un grupo fenilo, o (A2b) un grupo fenilo sustituido con halogeno); y n representa un numero entero de 1 a 6. Claim 1: An epoxy compound or a salt thereof, characterized by the general formula (2) wherein R 1 represents hydrogen or a lower alkyl group; R2 represents a piperidyl group represented by the general formula (A1) (where R3 represents: (A1a) a phenoxy group having halogen substituted lower alkoxy group (s) as a substituent (s) on a phenyl group, (A1b) a group phenyl-substituted inner alkyl having halogen-substituted inner alkyl group (s) as a substituent (s) on a phenyl ...

BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

TERPENE ARYL ETHERS

4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

BIOCOMPATIBLE BIODEGRADABLE FUMAGILLIN ANALOG CONJUGATES

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog. 124.-. (canceled)2631.-. (canceled)32. A composition comprising the compound or pharmaceutically acceptable salt of the compound of and a pharmaceutically acceptable carrier.3335.-. (canceled)36. A composition comprising a compound or pharmaceutically acceptable salt of the compound of and a pharmaceutically acceptable carrier.37. The composition of claim 36 , wherein the pharmaceutically acceptable carrier is suitable for injectable administration and the composition comprises an injectable dosage form.38. A method of treating cancer claim 25 , comprising administering to a subject in need thereof a compound or a pharmaceutically acceptable salt of a compound of claim 25 , in an amount effective to treat the cancer.39. The method of claim 38 , wherein the cancer is selected from the group consisting of anal claim 38 , astrocytoma claim 38 , leukemia claim 38 , lymphoma claim 38 , head and neck claim 38 , liver claim 38 , testicular claim 38 , cervical claim 38 , sarcoma claim 38 , hemangioma claim 38 , esophageal claim 38 , eye claim 38 , laryngeal claim 38 , mouth claim 38 , mesothelioma claim 38 , skin claim 38 , myeloma claim 38 , oral claim 38 , rectal claim 38 , throat claim 38 , bladder claim 38 , breast claim 38 , uterus claim 38 , ovary claim 38 , prostate claim 38 , lung claim 38 , colon claim 38 , ...

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor. This application is a continuation application of U.S. patent application Ser. No. 15/065,513, filed Mar. 9, 2017, now allowed, which is a continuation of Ser. No. 13/696,743, filed Nov. 7, 2012, now U.S. Pat. No. 9,320,805, which is a 35 U.S.C. 371 NATL phase entry of PCT/US2011/037857, filed May 25, 2011, which claims the benefit of, and priority to, U.S. Provisional Patent Application Ser. No. 61/347,924, filed May 25, 2010.Helmut Ringsdorf provided a theoretical framework for the design of polymer conjugates of small molecule drugs over thirty years ago (See Ringsdorf, “Structure and Properties of Pharmacologically Active Polymers”, J. POLYMER SCI.: Symposium No. 51, 135-153 (1975)). While many conjugates have been synthesized and evaluated in animals, few have progressed to clinical trials and those trials have been largely disappointing. The identification of polymer drug conjugates that represent improvements over the parent small molecules remains an area of active research.Fumagillin is a small molecule which has been used as an antimicrobial and antiprotozoal agent. Its physiochemical properties and method of production are well known (See U.S. Pat. No. 2,803,586 (Peterson, et al, incorporated herein by reference) and Turner, J. R. et al, The Stereochemistry of Fumagillin, Proc. Natl. Acad. Sci. 48, 733-735 (1962)). The fermentation product, fumagillin, may be hydrolyzed to yield the alcohol ...

Fungicidal Alkyl-Substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol Compounds

The present invention relates to the use of alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi and seed coated with at least one such compound. The invention also relates to novel alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound.

LINKER COMPOUNDS, METHODS OF PRODUCING THE SAME AND USES THEREOF

The present disclosure provides a bifunctional linker for coupling at least one functional moiety, preferably a bis-allyl propionic acid (BAPA), to a polymer-containing matrix. Also disclosed by the present disclosure are anhydrides of the bifunctional linker, processes for preparing the bifunctional linker and such anhydride, as well as surfaces, such as cellulose containing matrices, coupled with the bifunctional linker, at times, the latter carrying a functional agent. 2. The process of claim 1 , wherein Rand Reach represent —CH—CH═CH.3. The process of claim 1 , wherein Rrepresents a methyl.4. The process of claim 1 , wherein Xrepresents —O—CH—.5. The process of claim 1 , wherein Xrepresents —O—CH—.6. The process of claim 1 , wherein Rrepresents a carbonyl.7. The process of claim 6 , wherein W represents —OH or —Cl.9. (canceled)10. (canceled)12. (canceled)13. (canceled)15. The process of claim 14 , wherein said Rand Rare identical.16. The process of claim 14 , wherein said leaving group is a halogen.17. The process of claim 14 , wherein said reaction is carried out with a nucleophilic agent having the formula CH═CH—CH—Br.19. (canceled)22. (canceled)23. The process of claim 21 , wherein said amine containing compound is 4-Dimethylaminopyridine (DMAP).24. The process of claim 21 , wherein said polar aprotic solvent is dichloromethane (DCM) and said reaction medium comprises pyridine.25. (canceled)26. A functionalized polymer-containing matrix comprising at least one functional agent bound claim 1 , via a bifunctional linker of formula (I) as defined in claim 1 , where W is an oxygen group linked to the polymer containing matrix.27. (canceled)28. (canceled)29. A modified cellulose-containing matrix comprising covalently bound to its cellulose fibers bis-allyl propionic acid (BAPA) linker; and optionally to at least one functional agent.30. (canceled) The present disclosure relates to bifunctional linkers and their use in matrices functionalization.References ...

PHENALENE-1-ONE-CONTAINING PHOTOSENSITIZER COMPOSITION, PHENALENE-1-ONE COMPOUND AND THE USE THEREOF

A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof. 6. The phenalen-1-one compound as claimed in claim 5 ,wherein the residue Ar respectively independently of each other represents an unsubstituted or substituted phenyl residue, an unsubstituted or substituted biphenyl residue, an unsubstituted or substituted diphenylpropyl residue or an unsubstituted or substituted bisphenylsulphonyl residue.10. The photosensitizer composition as claimed in claim 1 , wherein the at least one polymeric component and/or precursor thereof is selected from the group which consists of polymers and/or copolymers of acrylic acid and esters thereof claim 1 , methacrylic acid and esters thereof claim 1 , cyanoacrylic acid and esters thereof claim 1 , acrylamide claim 1 , methacrylamide claim 1 , styrene claim 1 , siloxanes and esters thereof claim 1 , melamine claim 1 , acrylonitrile claim 1 , 1 claim 1 ,3-butadiene claim 1 , epichlorohydrin claim 1 , polyols claim 1 , polyisoprenes claim 1 , polyethers claim 1 , polyetherimides claim 1 , polyvinyl acetates claim 1 , polycarbonates claim 1 , polyether sulphones claim 1 , carboxymethyl cellulose claim 1 , alginate claim 1 , and combinations thereof.11. The photosensitizer composition as claimed in claim 1 , wherein the composition furthermore comprises at least one crosslinking agent claim 1 , which contains at least one polyisocyanate claim 1 , a blocked isocyanate claim 1 , at least one alkyl diisocyanate or cycloalkyl diisocyanate or aryl diisocyanate claim 1 , a compound with the general formula SiZ claim 1 , (R)SiZ claim 1 , (R)SiZ claim 1 , a compound containing at least two epoxy residues claim 1 , a compound containing at least two acrylamide residues claim 1 , a compound containing at least two acrylate residues claim 1 , a compound containing at least two aldehyde residues claim 1 , ...

FLUORINATED ARYL EPOXIDE COMPOUNDS

A fluorinated aromatic epoxy compound having a fluorinated ether tail and a pendant epoxy functional group. These compounds are particularly useful as starting materials for producing various water and oil repellents and soil resists. 2. The compound of claim 1 , wherein Ris —CF.3. The compound of claim 1 , wherein Ris —CF.4. The compound of claim 1 , wherein Ris —CFCFXCFand X is —F.5. The compound of claim 1 , wherein Ris —CFCFXCFand X is —OCF.6. The compound of claim 1 , wherein Z is a single bond claim 1 , —(CH)O— claim 1 , —OCHCH)O— claim 1 , or —(CH)(OCHCH)O—.7. The compound of claim 1 , wherein Y is H.8. The compound of claim 1 , wherein Y is Cl.9. The compound of wherein Y is Br.10. The compound of claim 1 , wherein R claim 1 , R claim 1 , and Rare H.12. The method of claim 11 , wherein the solvent is tetrahydrofuran claim 11 , carbon tetrachloride claim 11 , or carbon tetrabromide.13. The method of claim 12 , wherein the solvent is tetrahydrofuran.14. The method of claim 11 , wherein the base is potassium carbonate claim 11 , sodium carbonate claim 11 , or potassium bicarbonate.15. The method of claim 14 , wherein the base is potassium carbonate.16. A polymer obtained by polymerizing the composition of with appropriate epoxide reactive monomers and curing agents. The present invention relates to an aryl compound having a fluorinated ether group and a pendant epoxy group, useful for epoxy polymerization. The resulting polymers are useful for producing various water and oil repellents, soil resists, and surfactants.Water and oil repellants, soil resists, and surfactants are generally prepared from linear perfluorinated alcohols, which are expensive and are prepared through several step syntheses. These alcohols are either then reacted to make final products or further synthesized into intermediates prior to making final products. New starting materials are needed that do not utilize linear perfluorinated alcohols.Compounds other than linear perfluorinated ...

AROMATIC SUBSTITUTED ALKANE-CORE MONOMERS AND POLYMERS THEREOF FOR VOLUME BRAGG GRATINGS

The disclosure provides recording materials including aromatic substituted alkane-core derivatized monomers and polymers for use in volume Bragg gratings, including, but not limited to, volume Bragg gratings for holography applications. Several structures are disclosed, including Formula I. When used in Bragg gratings applications, the monomers and polymers disclosed lead to materials with higher refractive index, low birefringence, and high transparency. The disclosed derivatized monomers and polymers can be used in any volume Bragg gratings materials, including two-stage polymer materials where a matrix is cured in a first step, and then the volume Bragg grating is written by way of a second curing step of a monomer. 2. The compound of claim 1 , wherein the substituent comprises one or more linking groups selected from —Calkyl- claim 1 , —O—Calkyl- claim 1 , —Calkenyl- claim 1 , —O—Calkenyl- claim 1 , —Ccycloalkenyl- claim 1 , —O—Ccycloalkenyl- claim 1 , —Calkynyl- claim 1 , —O—Calkynyl- claim 1 , —Caryl- claim 1 , —O—C— claim 1 , -aryl- claim 1 , —O— claim 1 , —S— claim 1 , —S(O)— claim 1 , —C(O)— claim 1 , —C(O)O— claim 1 , —OC(O)— claim 1 , —C(O)S— claim 1 , —SC(O)— claim 1 , —OC(O)O— claim 1 , —N(R)— claim 1 , —C(O)N(R)— claim 1 , —N(R)C(O)— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —SC(O)N(R)— claim 1 , —N(R)C(O)S— claim 1 , —N(R)C(O)N(R)— claim 1 , —N(R)C(NR)N(R)— claim 1 , —N(R)S(O)— claim 1 , —S(O)N(R) claim 1 , —S(O)O— claim 1 , —OS(O)— claim 1 , —OS(O)O— claim 1 , —O(O)P(OR)O— claim 1 , (O)P(O—) claim 1 , —O(S)P(OR)O— claim 1 , and (S)P(O—) claim 1 ,{'sup': 'b', 'wherein w is 1 or 2, and Ris independently hydrogen, optionally substituted alkyl, or optionally substituted aryl.'}3. The compound of claim 1 , wherein the substituent comprises one or more linking groups selected from —(CH)— claim 1 , 1 claim 1 ,2 disubstituted phenyl claim 1 , 1 claim 1 ,3 disubstituted phenyl claim 1 , 1 claim 1 ,4 disubstituted phenyl claim 1 , disubstituted ...

POLYMER-CONJUGATED METAP2 INHIBITORS, AND THERAPEUTIC METHODS OF USE THEREOF

One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor. 2. The method of claim 1 , wherein the p-nitrophenyl fumagill-6-yl carbonate is contacted with the poly[HPMA-co-MA-GFLG-N-(trans-4-aminocyclohexylamine.HCl)] in the presence of a suitable base.3. The method of claim 1 , wherein the p-nitrophenyl fumagill-6-yl carbonate is contacted with the poly[HPMA-co-MA-GFLG-N-(trans-4-aminocyclohexylamine.HCl)] in the presence of a suitable solvent.4. The method of claim 3 , wherein the solvent is N claim 3 ,N-dimethylformamide.5. The method of claim 1 , wherein the p-nitrophenyl fumagill-6-yl carbonate is contacted with poly[HPMA-co-MA-GFLG-N-(trans-4-aminocyclohexylamine.HCl)] at a temperature of about 0° C. and allowed to warm to about room temperature.6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)12. The method of claim 11 , wherein the poly(HPMA-co-MA-GFLG-ONp) is contacted with the trans 1 claim 11 ,4-diaminocyclohexane in the presence of a suitable solvent.13. The method of claim 12 , wherein the suitable solvent is N claim 12 ,N-dimethylformamide.14. The method of claim 11 , wherein the poly(HPMA-co-MA-GFLG-ONp) is contacted with the trans 1 claim 11 ,4-diaminocyclohexane at a temperature of about 0° C. and allowed to warm to about room temperature.15. (canceled)16. (canceled)17. The method of claim 14 , further comprising adding aqueous sodium hydroxide to give a mixture with a pH of about 8.0.18. The method of claim 17 , wherein the mixture ...

COMPOUND, COMPOSITION CONTAINING THE SAME, METHOD FOR FORMING RESIST PATTERN AND METHOD FOR FORMING INSULATING FILM

A composition containing a polyphenol compound (B), 2. The composition according to claim 1 , further comprising a base material (A) claim 1 , wherein the base material (A) is one or more selected from the group consisting of a phenol novolac resin claim 1 , a cresol novolac resin claim 1 , a hydroxystyrene resin claim 1 , a (meth)acrylic resin claim 1 , a hydroxystyrene-(meth)acrylic copolymer claim 1 , a cycloolefin-maleic anhydride copolymer claim 1 , a cycloolefin claim 1 , a vinyl ether-maleic anhydride copolymer and an inorganic resist material having a metallic element claim 1 , and a derivative thereof.4. The composition according to claim 2 , wherein a mass ratio between the base material (A) and the polyphenol compound (B) is 5:95 to 95:5.5. The composition according to claim 1 , further comprising a solvent.6. The composition according to claim 1 , further comprising an acid generating agent.7. The composition according to claim 1 , further comprising a crosslinking agent.8. The composition according to claim 1 , wherein the composition is used in film formation for lithography.9. The composition according to claim 1 , wherein the composition is used in film formation for resist.10. A method for forming a resist pattern claim 1 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'forming a photoresist layer on a substrate using the composition according to ;'}irradiating a predetermined region of the photoresist layer formed on the substrate with radiation; anddeveloping the photoresist layer after the radiation irradiation.11. A method for forming an insulating film claim 1 , comprising the steps of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'forming a photoresist layer on a substrate using the composition according to ;'}irradiating a predetermined region of the photoresist layer formed on the substrate with radiation; anddeveloping the photoresist layer after the radiation irradiation. The present invention relates to a ...

REACTION PRODUCTS OF AMINO ACIDS AND EPOXIES

Reaction products of one or more amino acids and one or more epoxies are included in copper and copper alloy electroplating baths to provide good throwing power. Such reaction products may plate copper and copper alloys with good surface properties and good physical reliability. 1. A compound comprising a reaction product of one or more amino acids and one or more epoxies.2. The compound of claim 1 , wherein the reaction product further comprises one or more non-amino acid amines.3. The compound of claim 1 , wherein the one or more amino acids are chosen from α-amino acids claim 1 , β-amino acids and γ-amino acids.4. The compound of claim 3 , wherein the one or more α-amino acids are chosen from arginine claim 3 , alanine claim 3 , glycine claim 3 , tryptophan claim 3 , asparagine claim 3 , lysine claim 3 , histidine claim 3 , tyrosine claim 3 , glutamine claim 3 , proline and salts thereof.5. The compound of claim 1 , wherein a molar ratio of a moiety from the amino acid to a moiety from the epoxide ranges from 0.5:2-2:0.5.7. A composition comprising one or more sources of copper ions claim 1 , an electrolyte and one or more compounds comprising a reaction product of one or more amino acids and one or more epoxies.8. A method comprising:a) providing a substrate;b) providing a composition comprising one or more sources of copper ions, an electrolyte and one or more compounds comprising a reaction product of one or more amino acids and one or more epoxies;c) contacting a substrate with the composition;d) applying a current to the substrate and the composition; ande) depositing copper or copper alloy on the substrate.9. The method of claim 9 , wherein the one or more sources or metal ions are chosen from copper salts and tin salts.10. The method of wherein the substrate comprises a plurality of one or more of through-holes claim 9 , trenches and vias. The present invention is directed to reaction products of amino acids and epoxies for use in copper and copper alloy ...

Novel Biphenyl Derivative Compound and Use Thereof

The present disclosure provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to the present disclosure is a compound that increases Nm23-H1/NDPK activity and can inhibit cancer metastasis and growth. Thus, it exhibits excellent effects not only on the prevention, alleviation and treatment of cancer, but also on the suppression of cancer metastasis. 2. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein the Cto Calkoxy group is any one selected from the group consisting of methoxy claim 1 , ethoxy and propoxy groups.3. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein Rto Rare each independently hydroxy or methoxy.4. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 3 , wherein each of R claim 3 , R claim 3 , Rand Ris independently hydroxy or methoxy and wherein at least two of R claim 3 , R claim 3 , Rand Rare methoxy groups.5. The biphenyl derivative compound or pharmaceutically acceptable salt thereof according to claim 1 , wherein L is —(C—C)— claim 1 , and each of R claim 1 , R claim 1 , Rand Ris methoxy.7. A pharmaceutical composition for treating or preventing cancer claim 1 , the pharmaceutical composition containing claim 1 , as an active ingredient claim 1 , the biphenyl derivative compound or pharmaceutically acceptable salt thereof according to .8. The pharmaceutical composition of claim 7 , wherein the cancer is cancer selected from the group consisting of breast cancer claim 7 , lung cancer claim 7 , melanoma claim 7 , prostate cancer claim 7 , colorectal cancer claim 7 , bladder cancer claim 7 , bone cancer claim 7 , blood cancer claim 7 , thyroid cancer claim 7 , parathyroid cancer claim 7 , bone marrow cancer claim 7 , rectal cancer claim 7 , throat cancer claim 7 , ...

GLYCIDYL ETHERS OF LIMONENE DERIVATIVES AND OLIGOMERS THEREOF AS CURABLE EPOXY RESINS

Cured epoxy resins are widespread because of their excellent mechanical and chemical properties. Typically, epoxy resins based on bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers are used, but these are problematic for many sectors because of their effect on the endocrine system. The present invention relates to glycidyl ethers of limonene-based diols and/or polyols, and to curable epoxy resin compositions based thereon as alternatives to the bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers, or the epoxy resin compositions based thereon. 2: The glycidyl ether according to claim 1 , [{'sub': '2', 'R1=H and R2=CHOA and R3=H, or'}, {'sub': '2', 'R1=CHOA and R2=H and R3=H,'}], 'where'} [{'sub': '2', 'R4=H and R5=CHOA and R6=H, or'}, {'sub': '2', 'R4=CHOA and R5=H and R6=H,'}], 'and where'}and where A is a glycidyl group.3: The glycidyl ether according to claim 1 ,whereR3 and R6 are not both simultaneously a hydrogen atom.4: A process for preparing the glycidyl ether according to claim 2 , the process comprisinghydroformulating limonene with a mixture of carbon monoxide and hydrogen in the presence of a hydroformylation catalyst at elevated pressure to give a corresponding dialdehyde, andcatalytically hydrogenating the dialdehyde to give a corresponding diol, andreacting the diol with epichlorohydrin to give the glycidyl ether.5: A process for preparing the glycidyl ether according to claim 3 , the process comprisinghydroformylating limonene with a mixture of carbon monoxide and hydrogen in the presence of a hydroformylation catalyst at elevated pressure to give a corresponding dialdehyde, andreacting the dialdehyde with a carbonyl compound of formula R7R8C═O forming a new C—C bond in an aldol reaction to give a corresponding beta-hydroxy aldehyde,catalytically hydrogenating the beta-hydroxy aldehyde to give a corresponding tri- and tetrahydric alcohols, andreacting the tri- and tetrahydric alcohols with epichlorohydrin to give the glycidyl ...

Methods of treating age related disorders

The invention generally relates to methods of treating a patient having, and/or at risk of, oxidative distress disorders and/or age-related disorders. The disclosure also generally relates to methods of treating memory impairment or enhancing the cognitive function of a patient in need thereof. Such methods may include administering a therapeutically effective amount of a MetAP2 inhibitor.

NOVEL P62 LIGAND COMPOUND, AND COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING PROTEINOPATHIES COMPRING THE SAME

The present invention relates to a novel p62 ligand compound, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteinopathies comprising the same as an active ingredient. The p62 ligand compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various proteinopathies by activating autophagy in cells and thus selectively eliminating in vivo proteins, organelles and aggregates. 2. The compound claim 1 , a pharmaceutically acceptable salt claim 1 , stereoisomer claim 1 , hydrate claim 1 , solvate or prodrug thereof according to claim 1 , wherein the W is phenyl claim 1 , and n1 is 1 or 2.3. The compound claim 1 , a pharmaceutically acceptable salt claim 1 , stereoisomer claim 1 , hydrate claim 1 , solvate or prodrug thereof according to claim 1 , wherein the Ris hydrogen or —O—(CH)—R′ claim 1 , R′is phenyl that is unsubstituted or substituted by hydroxy claim 1 , fluoro claim 1 , chloro claim 1 , bromo claim 1 , methyl claim 1 , ethyl claim 1 , methoxy claim 1 , ethoxy claim 1 , nitro claim 1 , amino or dimethylamino claim 1 , and n2 is an integer of 1 to 4.4. The compound claim 1 , a pharmaceutically acceptable salt claim 1 , stereoisomer claim 1 , hydrate claim 1 , solvate or prodrug thereof according to claim 1 , wherein the Ris hydroxy claim 1 , or —O—(CH)—R′ claim 1 , R′is phenyl which is unsubstituted or substituted by hydroxy claim 1 , fluoro claim 1 , chloro claim 1 , bromo claim 1 , methyl claim 1 , ethyl claim 1 , methoxy claim 1 , ethoxy claim 1 , nitro claim 1 , amino or dimethylamino claim 1 , and n3 is an integer of 1 to 4.5. The compound claim 1 , a pharmaceutically acceptable salt claim 1 , stereoisomer claim 1 , hydrate claim 1 , solvate or prodrug thereof according to claim 1 , wherein the Ris —(CH)—OH claim 1 , —(CH)—NH—C(═NH)NH claim 1 , —C(═NH)NH claim 1 , methyl claim 1 , ethyl or ...

Oxygen absorbing agent

An oxygen absorbing agent containing a compound (A) of formula (I): wherein X is a chalcogen atom, R 1 and R 2 are each any one of an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, R 3 and R 4 are each any one of a hydrogen atom, an alkyl group which optionally has a substituent, an alkenyl group which optionally has a substituent, an aryl group which optionally has a substituent, and an aralkyl group which optionally has a substituent, and R 5 is a polymerizable group; and a transition metal salt (B).

Glycidyl ethers of limonene derivatives and oligomers thereof as curable epoxy resins

Cured epoxy resins are widespread because of their excellent mechanical and chemical properties. Typically, epoxy resins based on bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers are used, but these are problematic for many sectors because of their effect on the endocrine system. The present invention relates to glycidyl ethers of limonene-based diols and/or polyols, and to curable epoxy resin compositions based thereon as alternatives to the bisphenol A diglycidyl ethers or bisphenol F diglycidyl ethers, or the epoxy resin compositions based thereon.

Reaction products of amino acids and epoxies

The reaction product of one or more amino acids and one or more epoxies is included in the copper and copper alloy electroplating bath to provide good uniform electrodepositability. Such reaction products are capable of plating copper and copper alloys with good surface characteristics and good physical reliability.

Derivative of epichlorohydrin of natural origin

Derivative of epichlorohydrin of natural origin, selected from the group consisting of glycidyl ethers presenting an epoxide equivalent weight higher than or equal to 50 g/equivalent and lower than or equal to 15000 g/equivalent, of glycidyl esters, of glycidyl amides, of glycidyl imides, of glycidyl amines, and of any mixture thereof, and of which the 14 C mass content is such that the ratio 14 C/ 12 C is higher than 0.7 10 −12 .

Fungicidal alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds

The present invention relates to alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula 8I) as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound. Compounds of formula (I). Compounds of formulae (Va, VII, XI, XII and XIII).

Fungicidal alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds

The present invention relates to the use of alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof for combating harmful fungi and seed coated with at least one such compound. The invention also relates to novel alkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound.

Fungicidal phenylalkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds

The present invention relates to phenylalkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1 -[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof, their preparation and intermediates for preparing them. The invention also relates to the use of these compounds for combating harmful fungi and seed coated with at least one such compound and also to compositions comprising at least one such compound.

Aromatically Substituted Alkane Core Monomers and Their Polymers for Volume Bragg Gratings

本開示は、ホログラフィー用途の体積ブラッググレーティングを含むがこれに限定されない体積ブラッググレーティングにおける使用のための、芳香族置換アルカンコア誘導体化モノマー及びポリマーを含む記録材料を提供する。式Ｉを含むいくつかの構造が開示されている。ブラッググレーティング用途に使用される場合、本開示のモノマー及びポリマーは、高屈折率、低複屈折率、及び高透明性を有する材料をもたらす。本開示の誘導体化モノマー及びポリマーは、マトリックスが第１のステップで硬化され、その後モノマーの第２の硬化ステップとして体積ブラッググレーティングが書き込まれる二段階ポリマー材料を含む、任意の体積ブラッググレーティング材料において使用することができる。【選択図】なし

The MetAP2 inhibitor of polymeric conjugation and its Therapeutic Method of application

本发明的一个方面提供了聚合物缀合的MetAP2抑制剂。尽管不受任何具体理论约束，据信，经由本文所述的连接物偶联MetAP2抑制核心会提供具有比亲本小分子更好效力和优良药代动力学分布的化合物。在本发明的一个方面，所述聚合物缀合的MetAP2抑制剂可用于治疗疾病的方法中，所述方法包括：给有此需要的受试者施用治疗有效量的聚合物缀合的MetAP2抑制剂。

Novel biphenyl derivative compound and use thereof

본 발명은, 신규 바이페닐 유도체 화합물, 또는 이의 약학적으로 허용가능한 염을 제공한다. 본 발명에 따른 바이페닐 유도체 화합물, 또는 이의 약학적으로 허용가능한 염은 Nm23-H1/NDPK 활성 증진 물질로 암의 전이 및 성장을 억제할 수 있어 암의 예방, 개선 및 치료뿐만 아니라 암전이 억제에 우수한 효과를 나타낸다.

Synthesis intermediate of Entecavir and preparation method thereof

本发明涉及恩替卡韦的合成中间体及其制备方法，具体而言，涉及用于制备恩替卡韦的式II的合成中间体、所述中间体的制备方法以及利用式II的中间体制备恩替卡韦的方法，其中R和R’如说明书中所定义。

Novel autophagy-targeting chimera (autotac) compound, and composition for preventing, alleviating, or treating diseases through target protein degradation comprising same

The present invention relates to: an autophagy-targeting chimera (AUTOTAC) compound in which a novel p62 ligand and a target-binding ligand are linked by means of a linker, or a stereoisomer, solvate, hydrate, or prodrug of the AUTOTAC compound; and a pharmaceutical or food composition for preventing or treating diseases through target protein degradation comprising same as an active ingredient. The present invention not only allows a concentration adjustment with a specific protein targeted, but also allows delivery of drugs and other low molecular weight compounds to lysosomes. The AUTOTAC compound according to the present invention selectively removes specific proteins and thus can be usefully employed as a pharmaceutical composition for preventing, alleviating, or treating various diseases.

Multifunctional epoxy compounds having multiple liquid crystalline cores and cured products prepared therefrom

본 발명은 복수 개의 열방성 액정 물질이 결합되어 합성된 액정 분자의 말단 부위에 둘 이상의 에폭사이드 작용기를 수식하여 수득된 다작용기성 에폭시 화합물 및 상기 화합물과 경화제를 반응시켜 제조된 경화물에 관한 것으로서, 보다 구체적으로 액정 간의 상호작용이 용이하고, 열전도도가 높아 방열 고분자로 단독 활용 또는 복합재료의 형태로 사용가능하며, 복합재료의 기지 수지로 응용가능한 화합물 및 경화물에 관한 것이다.

Lithographic film formation material, composition for lithographic film formation, lithographic film, pattern formation method, and purification method

FUNGICIDE COMPOUNDS 2- [2-CHLORO-4- (4-CHLORO-PHENOXY) -PHENYL] -1- [1,2,4] TRIAZOL-1-IL-ETHANOL ALKYL SUBSTITUTE

SE REFIERE A COMPUESTOS DERIVADOS DE 2-[2-CLORO-4-(4-CLORO-FENOXI)-FENIL]-1-[1,2,4]TRIAZOL-1-IL-ETANOL ALQUILO DE FORMULA (I) DONDE R1 ES ALQUILO(C2-C6), ALQUENILO(C2-C6), CICLOALQUILO(C3-C8), ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION AGROQUIMICA QUE PUEDE CONTENER OTRO COMPUESTO ACTIVO. DICHOS COMPUESTOS SON FUNGICIDAS UTILES PARA COMBATIR HONGOS FITOPATOGENICOS REFERS TO COMPOUNDS DERIVED FROM 2- [2-CHLORO-4- (4-CHLORO-PHENOXY) -PHENYL] -1- [1,2,4] TRIAZOL-1-IL-ETHANOL ALKYL OF FORMULA (I) WHERE R1 IT IS ALKYL (C2-C6), ALKENYL (C2-C6), CYCLOALKYL (C3-C8), AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND AN AGROCHEMICAL COMPOSITION THAT MAY CONTAIN ANOTHER ACTIVE COMPOUND. SAID COMPOUNDS ARE USEFUL FUNGICIDES TO COMBAT PHYTOPATOGENIC FUNGI

Epoxy compound and method for manufacturing the same

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound.

Novel P62 ligand compound and composition for preventing, ameliorating or treating protein conformational diseases comprising the same

本发明涉及一种新颖的p62配体化合物或者其立体异构体、水合物、溶剂化物或前药；以及包含其作为活性成分的用于预防或治疗蛋白质构象病的药物或食品组合物。根据本发明的p62配体化合物可有效地用作通过活化细胞中的自噬且因此选择性地消除活体内蛋白质、细胞器合聚集体来预防、改善或治疗各种蛋白质构象病的药物组合物。

High heat monomers and methods of use thereof

High purity epoxide compounds, methods for preparing the high purity epoxide compounds, and compositions derived from the epoxide compounds are provided. Also provided are materials and articles derived from the epoxide compounds.

Novel p62 ligand compound and composition for prevention, improvement or treatment of protein abnormal disease containing the same

【課題】非選択的オートファジーの調節因子であるｍＴＯＲの活性を低下することなく、選択的オートファジーの核心調節因子であるｐ６２を活性化して変性タンパク質凝集体を除去する方法の開発。【解決手段】本発明は、新規なｐ６２リガンド化合物、その立体異性体、溶媒和物、水和物またはプロドラッグ、これを有効性分として含む変形タンパク疾患の予防または治療用薬学的または食品組成物に関し、本発明によるｐ６２リガンド化合物は、細胞内選択的オートファジーを活性化して体内タンパク質、小器官および凝集体を選択的に除去することによって、多様なタンパク質異常疾患の予防、改善または治療用薬学的組成物として有用に使用できる。【選択図】図１

Production of epoxy compound

(57)【要約】 【課題】 一般的に入手可能な基礎化学品から出発し、 適用条件及び現在の環境規制の要求に合致した安価なエ ポキシ化合物の製造プロセスの提供。 【解決手段】 カチオン触媒の存在下に、ハロゲン、ア セテート、ホスフェート又はカルボキシレート或いはそ れらの組み合わせから選ばれる対アニオンＸ−と共に、 ビス環状カーボネートエステルをアルキレンオキシドと 反応させてエポキシ化合物を製造する。ビス環状カーボ ネートエステルは、例えばビスフェノールＡとグリシド ールの反応生成物をプロピレンカーボネートとエステル 交換することにより調製することができる。

3-Methyl-3-aryl-pyruvic acid esters and process for their preparation

Biocompatible biodegradable fumagillin analog conjugates

Fumagillin analog polymer conjugates, methods of making fumagillin analog polymer conjugates, compositions comprising a polymer conjugate of a fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a polymer conjugate of a fumagillin analog, are described. Also described are novel fumagillin analogs, methods of making fumagillin analogs, compositions comprising at least one fumagillin analog, and methods for treating cancer, or treating angiogenic diseases comprising administering to a subject in need thereof an effective amount of a fumagillin analog.

A process for the preparation of glycidyl-2-propenyl ether

0.01 to 5 mole part of ruthenium(triphenylphosphate) chloride by aryl glycidyl ether is used as catalyst at the temperature ranged of 100 to 130 degree Celsius to yield glycidyl-2-prophenyl ether of general formula(I). In general formula(I), R represents alkyl, groups selected from aromatic or CO, X and Y represent CH3 respectively. X and Y can be same groups.

compounds, process for preparing the compounds, agrochemical compositions, use of the compounds and seed coated

Method for obtaining biosourced polyepoxides with improved properties

L'invention concerne un procédé de préparation d'une composition de prépolymères époxy comprenant des glycidyléthers, ledit procédé comprenant les étapes suivantes : a) Mettre en contact un dianhydrohexitol et un autre alcool de manière à obtenir une composition d'alcools; b) Faire réagir la composition d'alcools obtenue à l'étape a) avec une épihalohydrine de manière à obtenir un mélange réactionnel comprenant des glycidyléthers; c) Récupérer la composition de prépolymères époxy comprenant des glycidyléthers à partir du mélange réactionnel obtenu à l'issue de l'étape b); L'invention concerne également une composition de prépolymères époxy susceptible d'être obtenue par ledit procédé, une composition durcissable comprenant ladite composition de prépolymères époxy, un polyépoxyde obtenu par durcissement de ladite composition durcissable et un matériau composite, revêtement ou adhésif comprenant ledit polyépoxyde.

Epoxy compound and method for manufacturing the same

Method for producing epoxy resin

Process for reducing the content of hydrolysable chlorine in glycidyl compounds

Novel biphenyl derivative compound and use thereof

The present invention provides a novel biphenyl derivative compound or a pharmaceutically acceptable salt thereof. A biphenyl derivative compound or a pharmaceutically acceptable salt thereof, according to the present invention, is a substance for enhancing Nm23-H1/NDPK activity and can inhibit metastasis and growth of cancer, thereby exhibiting excellent effects not only in prevention, improvement, and treatment of cancer, but also in inhibition of metastasis of cancer.

Novel p62 ligand compound, and composition for preventing, ameliorating or treating proteinopathies compring the same

本發明係關於一種新穎的p62配體化合物、其立體異構體、水合物、溶劑合物或前藥及包含其作為活性成分之用於預防或治療錯誤摺疊之蛋白質疾病的醫藥或食品組成物。根據本發明之p62配體化合物可有效地用作一種用於藉由活化細胞中之選擇性自噬且因此選擇性地消除活體內蛋白質、細胞器以及聚集體來預防、改善或治療各種蛋白質構象病之醫藥組成物。

Novel Autophagy-Targeting Chimera (AUTOTAC) Compound, and Composition for Preventing, Alleviating, or Treating Diseases Through Target Protein Degradation Comprising Same

OF DISCLOSURE The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, 10 and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver 15 drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by 20 selectively eliminating specific proteins. Representative Figure: FIG. 1 25 1/15 [Figure] [Fig. 1] Target-Binding Autophagy-Targeting Ligand (TBL) Ugand (ATl) Unker (Phagophore Autophagome I Autophagy AtJLCTAC dC3 5 ~eceptor AotophagyDgrato aF oly Polymerization Target inactivated S and sequestered Climeric igendling Lysosome

Anti-mycotic agent and preparation method thereof and intermediate

以下通式所示的化合物或其盐,其中间体或中间体的盐,以及其制备方法和适于作为抗真菌剂的药物组合物:其中R 1 和R 2 表示卤原子或氢原子;R 3 表示氢原子或低级烷基;1、r和m为0或1;A为N或CH;W表示芳香环或其稠环;X表示另一个芳香环、链烷二基、链烯二基或链炔二基;Y为－S－等;Z表示氢原子等。

Imidazole and triazole derivatives having antifungal activiti, processes for the preparation thereof, and pharmaceutical compositions containing the same

Epoxy compound and method for manufacturing the same.

La presente invención proporciona un producto intermedio novedoso para la fabricación de un compuesto de 2,3-dihjdrojmjdazo[2,1-b]ox azol con un rendimiento alto y una pureza alta y un método de fabricación del producto intermedio. La presente invención proporciona un compuesto de epoxi representado por la fórmula general (2): en donde, R1 representa hidrógeno o un grupo alquilo inferior; y R2 representa un grupo piperidilo simbolizado por la fórmula general (A1): (en donde R3 representa un grupo fenoxi que tiene un grupo alcoxi inferior sustituido por halógeno sustituido en un grupo fenilo y similares) y similares; y n representa un número entero de 1 a 6, un método de fabricación del compuesto de epoxi y un método de fabricación de un compuesto de oxazol utilizando el compuesto de epoxi.

Production method of carboxylic acid compound

The present invention provides the production method of carboxylic acid compound, as shown in Scheme I.

Antifungal and its preparation method and intermediate

以下通式所示的化合物或其盐，其中间体或中间体的盐，以及其制备方法和适于作为抗真菌剂的药物组合物：其中R 1 和R 2 表示卤原子或氢原子；R 3 表示氢原子或低级烷基；1、r和m为0或1；A为N或CH；W、X、Y和Z如权利要求书中所定义。

Lithographic film formation material, composition for lithographic film formation, lithographic film, pattern formation method, and purification method

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): wherein, each R° independently represents a monovalent group having an oxygen atom, a monovalent group having a sulfur atom, a monovalent group having a nitrogen atom, a hydrocarbon group or a halogen atom, and each p is independently an integer of 0 to 4.

Photosensitive resin composition, cured film, component of touch panel, and tft substrate

4 - ((Phenoxyalkyl) thio) -phenoxyacetic acids and analogues, pharmaceutical composition and use of the compounds

Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof

The present invention relates to a phenalene-1-one compound, a photosensitizer composition comprising said phenalene-1-one compound, an article comprising said phenalene-1-one compound and/or photosensitizer composition and the use thereof.

Novel autophagy-targeting chimera (autotac) compound, and composition for preventing, alleviating, or treating diseases through target protein degradation comprising same

The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composition for the prevention or treatment of diseases by degrading the target protein including the same as an active ingredient. They can target specific proteins to adjust their concentrations, and can also deliver drugs and other small molecule compounds to lysosomes. The AUTOTAC chimeric compound according to the present invention can be usefully used as a pharmaceutical composition for the prevention, amelioration or treatment of various diseases by selectively eliminating specific proteins.

ACIDS 4 - ((PHENOXIALQUIL) UNCLE) -PHENOXYACETICS AND ANALOGS

1.- Un compuesto de la fórmula (I):en donde X se selecciona de un enlace covalente, S y O; Y es S u O; Z es O o CH2, siempre que cuando Y es O, Z es O; R1 y R2 se seleccionan independientemente de H, alquilo de C1-3, alcoxi de C1-3, halógeno, y NRaRb en donde Ra y Rb son independientemente H o alquilo de C1-3; R3 y R4 se seleccionan independientemente de H, halógeno, ciano, alquilo de C1-5, hidroxi, acilo de C2-4, alcoxi de C1-4, y NRcRd en donde Rc y Rd son independientemente H o alquilo de C1-3, siempre que R3 y R4 no sean ambos H; R5 y R6 se seleccionan independientemente de halógeno, fenilo, alquilo de C1-9, alcoxi de C1-8, alquenilo de C2-9, alqueniloxi de C2-9, cicloalquilo de C3-7, cicloalcoxi de C3-7, cicloalquilo de C3-7alquilo de C1-7, cicloalquilo de C3-7-alcoxi de C1-7, cicloalquiloxi de C3-7-alquilo de C1-6, y cicloalquiloxi de C3-7alcoxi de C1-7, o R5 y R6 juntos forman alquidenilo deC1-9 o alquenildenilo de C3-9, o R5 y R6 y el átomo de carbono al cual están unidos forman cicloalquilo de C3-7 oheterociclo de 5 ó 6 miembros; n es 0, 1 ó 2; y m es 0, 1 ó 2; o una sal farmacéuticamente aceptable del mismo.

Film-forming material for lithography, film-forming composition for lithography, method for forming film or pattern for lithography, and purification method

本發明之微影用膜形成材料，其含有下述式(1)所示之化合物。 (式(1)中，R 0 各自獨立，為含氧原子之1價的基、含硫原子之1價的基、含氮原子之1價的基、烴基或鹵素原子，p各自獨立，為0~4之整數)。

New intermediates

Fluorinated ether compound, lubricant for magnetic recording medium, and magnetic recording medium

本发明涉及下述式(1)表示的含氟醚化合物。R 1 ‑CH 2 ‑R 2 ‑CH 2 ‑R 3 (1)(式(1)中，R 1 为包含2个以上的极性基团、各极性基团分别键合于不同的碳原子、前述极性基团所键合的碳原子彼此介由包含未键合极性基团的碳原子的连接基团进行键合而形成的末端基团，R 2 包含下述式(3)表示的全氟聚醚链，R 3 为羟基或R 1 。)‑(CF 2 ) y‑1 ‑O‑((CF 2 ) y O) z ‑(CF 2 ) y‑1 ‑(3)(式(3)中，y表示2～4的整数，z表示1～30的整数)。

Macromonomer compounds, their preparation from diene compounds and their use

The present invention relates to macromonomer compounds having the formula (I) where R1 is hydrogen, halogen, and optionally substituted alkyl, aryl, alkylaryl or arylalkyl radical; R2 and R3, which can be similar or different, are hydrogen, halogen, alkyl, aryl, alkylaryl, arylalkyl or alkoxy radical; R4 is an optionally substituted alkyl, aryl, alkylaryl or arylalkyl radical, or —XR5, with R5 being hydrogen, and optionally substituted alkyl, aryl, alkylaryl or aryalkyl; X is oxygen or sulphur; A corresponds to a unit issued from at least one ethylenically unsaturated monomer; and n is comprised between 1 and 10000. The invention also relates to dienic compounds having the formula (II): H2C═CR1—CH═CH—C(R2)(R3)—X2—R6 wherein R1 R2, R3 and X have the same meaning as above and R6 represents R5 or a group —COR7 or —COOR7 with R7 being alkyl, aryl, alkylaryl or arylalkyl.

Terpene aryl ethers, processes for their preparation and pesticides containing them

Novel autophagy-targeting chimera (autotac) compound, and composition for preventing, alleviating, or treating diseases through target protein degradation comprising same

Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof

A phenalene-1-one compound, a photosensitizer composition including the phenalene-1-one compound, an article including the phenalene-1-one compound and/or photosensitizer composition and the use thereof.

Polymer-conjugated MetAP2 inhibitors and methods of treatment using the same

本发明的一个方面提供了聚合物缀合的MetAP2抑制剂。尽管不受任何具体理论约束，据信，经由本文所述的连接物偶联MetAP2抑制核心会提供具有比亲本小分子更好效力和优良药代动力学分布的化合物。在本发明的一个方面，所述聚合物缀合的MetAP2抑制剂可用于治疗疾病的方法中，所述方法包括：给有此需要的受试者施用治疗有效量的聚合物缀合的MetAP2抑制剂。

Biocompatible biodegradable fumagillin analog conjugates

Novel p62 ligand compound, and composition for preventing, alleviating, or treating proteinopathies comprising same

Method for preparing glycidyl-2-propenyl ether

본 발명은 에폭시수지에 희석제로 사용되는 저분자량의 경화성 물질에 고나한 것으로 더욱 상세하게는 다음 구조식(1)의 글리시딜-2-프로페닐 에테르의 제조에 있어서, 알릴 글릴시딜 에테르에 대해 루테니움(트리페닐포스페이트)클로아이드[Ru(PPh 3 )Cl]0.01 내지 5몰%의 양을 반응 촉매로 사용하여 일정한 온도를 반응시키는 것을 특징으로 하는 글리시딜-2-프로페닐 에테르의 제조방법이다. 윗식에서, R은 알킬, 방향족 또는 CO기에서 선택한 군이고, X 및 Y는 H 또는 CH 3 이고, 같거나 다를 수 있다. 본 발명의 제조방법은 단일 단계이고, 이 제조방법의 수율은 약 95%로 얻어진다.

Novel hybride materials and related methods and devices

The invention provides devices and methods for end and side derivatization of carbon nanotubes. Also facile methods to attach moieties and nanoparticles on the side walls and both ends are described. The invention provides hybide materials for analytical, and optoelectronic purposes as well as materials applications. Materials have improved properties in the areas of tensile, electrical and thermal conductivity.

Film-forming material for lithography, film-forming composition for lithography, method for forming film or pattern for lithography, and purification method

本發明之微影用膜形成材料，其含有下述式(1)所示之化合物。 □ (式(1)中，R0各自獨立，為含氧原子之1價的基、含硫原子之1價的基、含氮原子之1價的基、烴基或鹵素原子，p各自獨立，為0~4之整數)。

Epoxy compound and process for its preparation

Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof

Epoxy compound and method for manufacturing the same

The present invention provides a novel intermediate for manufacturing a 2,3-dihydroimidazo[2,1-b]oxazole compound with a high yield and a high purity, and a manufacturing method of the intermediate. The present invention provides an epoxy compound represented by the general formula (2): wherein, R1 represents hydrogen or a lower alkyl group; and R2 represents a piperidyl group represented by the general formula (A1): (wherein, R3 represents a phenoxy group having a halogen-substituted lower alkoxy group substituted on a phenyl group, and the like) and the like; and n represents an integer of 1 to 6, a manufacturing method of the epoxy compound, and a manufacturing method of an oxazole compound using the epoxy compound.

Macromonomeres compounds, their preparation from dienic compounds and use thereof

The present invention relates to macromonomer compounds having the formula (I) where R1 is hydrogen, halogen, and optionally substituted alkyl, aryl, alkylaryl or arylalkyl radical; R?2 and R3¿, which can be similar or different, are hydrogen, halogen, alkyl, aryl, alkylaryl, arylalkyl or alkoxy radical; R4 is an optionally substituted alkyl, aryl, alkylaryl or arylalkyl radical, or -XR5, with R5 being hydrogen, and optionally substituted alkyl, aryl, alkylaryl or aryalkyl; X is oxygen or sulphur; A corresponds to a unit issued from at least one ethylenically unsaturated monomer; and n is comprised between 1 and 10000. The invention also relates to dienic compounds having the formula (II): H¿2C=CR?1-CH=CH-C(R?2)(R3)- X¿2-R6 wherein R?1, R2, R3¿ and X have the same meaning as above and R6 represents R5 or a group -COR7 or -COOR?7 with R7¿ being alkyl, aryl, alkylaryl or arylalkyl.

Fungicidal phenylalkyl-substituted 2-[2-chloro-4-(4-chloro-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds

本发明涉及说明书中所定义的式I的苯基烷基取代的2-[2-氯-4-(4-氯苯氧基)苯基]-1-[1,2,4]三唑-1-基乙醇化合物及其N-氧化物和盐，其制备及用于制备它们的中间体。本发明还涉及这些化合物在防治有害真菌中的用途和涂有至少一种该化合物的种子以及包含至少一种该化合物的组合物。

New intermediates

Antifungal agents, methods for their preparation and intermediates

본 발명은 하기 일반식(1)의 화합물 또는 그의 염, 및 그의 중간체 또는 그의 염 뿐만 아니라 그의 제조 방법 및 항진균제로서 사용하기 적합한 제약 조성물에 관한 것이다. 상기 식 중, R 1 및 R 2 는 할로겐 원자 또는 수소 원자를 의미하고, R 3 은 수소 원자 또는 저급 알킬기를 의미하고, ℓ, r 및 m은 0 또는 1을 의미하고, A는 N 또는 CH를 의미하고, W는 방향족 고리 또는 그의 축합 고리를 의미하고, X는 다른 방향족 고리, 알칸디일기, 알켄디일기 또는 알킨디일기를 의미하고, Y는 -S-등을 의미하고, Z는 수소원자 등을 의미한다.

Two part epoxy adhesive composition containing acid anhydride-based epoxy compound modified with fatty acid and cured product prepared therfrom

Through the introduction of a fatty acid-modified acid anhydride-based epoxy compound according to the present invention, it is possible to prepare a composition by designing desired mechanical properties by effectively improving the toughness of conventional epoxy resins. Specifically, by adding the fatty acid-modified acid anhydride-based epoxy compound to the composition of an adhesive and coating material for a lightweight heterogeneous material of automobiles, the compound can be used as a functional adhesive composition for different materials by improving adhesive performance such as tensile strain, shear strength, T-peel strength and the like of a product.<quillbot-extension-portal></quillbot-extension-portal>