Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake.

Novel benzothiepines, derivatives, and analogs thereof; methods of preparing such compounds; pharmaceutical compositions containing such compounds; and methods of using these compounds and compositions in the preparation of a medicament, particularly medicaments for use in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake.

Novel benzothiepines having activity as inhibitors of ideal bile acid transport and tautocholate uptake

BIOLOGICALLY EFFECTIVE ONES, HETEROBICYCLI HYDROXIMIDATE AND THIOLHYDROXIMIDATE AND THEIR CARBAMATESTER DERIVATIVES.

BENZOTHEPINES WITH EFFECT AS INHIBITORS OF BILE ACID TRANSPORT AND THE TAUROCHOLATE ADMISSION

AMINOMETHYL DIBENZO (A,E) CYCLOPROPA(A)CYCLOHEPTAN-6-ONES

BIOLOGICALLY ACTIVE HETEROCYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

This invention relates to novel benzothiepines, derivatives and analogs thereof, pharmaceutical compositions containing them and their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as is associated with atherosclerosis, or hypercholesterolemia, in mammals.

PROCEDURE FOR THE PRODUCTION OF AMINOSUBSTITUIERTER OF TETRACYCLI CONNECTIONS.

PROCEDURE FOR THE PRODUCTION OF NEW OF AMINOSUBSTITUIERTER OF TETRACYCLI CONNECTIONS.

PROCEDURE FOR THE PRODUCTION OF NEW OF AMINOSUBSTITUIERTER OF TETRACYCLI CONNECTIONS.

БЕНЗОТИЕПИНЫ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ ИНГИБИТОРОВ ПЕРЕМЕЩЕНИЯ ЖЕЛЧНЫХ КИСЛОТ В ПОДВЗДОШНОЙ КИШКЕ И ПОГЛОЩЕНИЯ ТАУРОХОЛАТА

... 1. Соединение, имеющее структурную формулу где R 2. Соединение по п.1, имеющее структурную формулу 3. Соединение по п.1, имеющее структурную формулу 4. Соединение по п.1, имеющее структурную формулу 5. Соединение по п.1, имеющее структурную формулу 6. Соединение по п.1, имеющее структурную формулу 7. Соединение по п.1, имеющее структурную формулу 8. Соединение по п.1, имеющее структурную формулу 9. Соединение по п.1, имеющее структурную формулу 10. Соединение по п.1, имеющее структурную формулу 11. Соединение по п.1, имеющее структурную формулу 12. Соединение по п.1, имеющее структурную формулу 13. Соединение по п.1, имеющее структурную формулу 14. Соединение по п.1, имеющее структурную формулу 15. Соединение, имеющее структурную формулу где R 16. Соединение по п.15, имеющее структурную формулу 17. Соединение по п.15, имеющее структурную формулу 18. Соединение, выбранное из группы, включающей и 19. Фармацевтическая композиция, содержащая соединение по любому из пп.1-18 в антигиперлипидемически ...

BENZOTHIEPINES, HAVING ACTIVITY INHIBITORS OF DISPLACEMENT ILEUM BILE ACID AND ABSORPTION TAURKhOLATA

Benzothiepines Having Activity As Inhibitors of Ileal Bile Acid Transport and Taurocholate Uptake

1. Technical Result Increase in assortment of medicinal means for treatment of hyperlipidemic conditions and prophylaxis. 2. Essence Novel benzothiepines, derivatives, and analogs thereof; methods of preparing such compounds and compositions containing such compounds, in particular using these compounds and compositions in the preparation of a medicament, particularly medicaments for use in the prophylaxis and treatment of hyperlipidemic conditions. 3. Field of Application Medicine.

Amino-substituted tetracyclic compounds

6H-dibenz(b,f)thiepin compounds

6H-DIBENZ(B,F)THIEPINE COMPOUND

AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS

1461834 Amino-substituted tetracyclic compounds AKZO NV 19 April 1974 [2 May 1973] 17343/74 Heading C2C Novel compounds I (X is O, S, NR 7 or CR 8 R 9 ; R 1 to R 4 are H, OH, halo, 1-6C alkyl, alkoxy or alkylthio or CF 3 ; R 5 and R 6 are H, 1-6C alkyl, or 7-10C aralkyl; or NR 5 R 6 is a 5-6 membered heterocyclic ring; R 7 is H or 1-4C alkyl; R 8 and R 9 are H or CH 3 ; n is 0, 1 or 2; and the dotted line indicates an optional band) and salts thereof are prepared by known methods. Compounds II are prepared by condensation of vinyl methyl ketone with a compound III Compounds II may be reduced, using LiAlH 4 , to give the corresponding 2-hydroxy derivatives. These may be converted by known methods to the corresponding 2-mesyloxy-2-azido-, and 2- cyano-derivatives. 2 - Cyanomethylidene - 1,2,3,4 - tetrahydrotribenzo(b,d,f)oxepine is prepared by reaction of the appropriate compound II with acetonitrile and sodium ethoxide. 2 - N,N - Dimethylcarbamyl - methyl - 1,2,3,4- tetrahydro - 9H - tribenzo(b,d,f)cycloheptatriene is prepared by reaction of the appropriate compound II with triethyl phosphonoacetate/NaH to give 2-ethoxycarbonyl methyl-3,4-dihydro-9H- tribenzo(b,d,f)cycloheptatriene, catalytic hydrogenation of this and reaction with dimethylamine. The above-mentioned 2-cyano-derivatives may be hydrolysed to give the corresponding 2-carboxy-derivatives. Pharmaceutical compositions having C.N.S. activity comprise a compound I together with the usual carriers and/or diluents.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

BENZOTHIEPINES HAVING ACTIVITY OF INHIBITORS OF MOVING BILE ACIDS IN GLOMERULAR GUT AND TAUROCHOLATE ABSORPTION

Amino-substituted tetracyclic compounds

EXCITATORY AMINO ACID DERIVATIVES

Compounds for formula (I) in which: Y represents O, NRa, S, SO or SO2; X1represents (CR1R2)m; X2 represents (CR3R4)n; one of m and n is 1 and the other is 0 or 1; and R1, R2, R3and R4 are each as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and pharmaceutically acceptable salts thereof; are useful as modulators of metabotropic glutamate receptor function.

AMINOMETHYL DIBENZO(A,E) CYCLOPROPA(C) CYCLOHEPTAN-6-ONES

BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

Novel benzothiepines, derivatives, and analogs thereof; methods of preparing such compounds; pharmaceutical compositions containing such compounds; and methods of using these compounds and compositions in the preparation of a medicament, particularly medicaments for use in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

6H-DIBENZ(B,F)THIEPIN COMPOUNDS

A novel group of dibenz¢b,f! thiepins having a fourth ring of five or six carbon atoms, fused to the main ring system. These compounds have the following general formula: The compounds are employed in the treatment and control of allergic conditions such as asthma.

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

BENZOTHIEPINEN WITH EFFECT AS INHIBITORS OF THE ILEUMGALLENSÄURETRANSPORTS AND THE TAUROCHOLATE ADMISSION

6-H dibenz[b,f]thiepin compounds

Novel dibenz[b,f]thiepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. < IMG > ...

ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME

6H-DIBENZ(B,F)THIEPIN COMPOUNDS

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING SAME

The present invention relates to a novel compound and an organic electroluminescent device comprising the same. The compound according to the present invention is used in an organic layer of the organic electroluminescent device, and preferably a light emitting layer, an electron transport layer, a hole transport layer, or an electron transport auxiliary layer, thereby being able to improve light emitting efficiency, driving voltage, and lifespan properties of the organic electroluminescent device. COPYRIGHT KIPO 2017 ...

BENZOTHEPINES MIT WIRKUNG ALS INHIBITOREN DES GALLENSÄURETRANSPORTS UND DER TAUROCHOLATE-AUFNAHME

1,2,3,4-TETRAHYDRO-TRIBENZO (B.D.F.)-AZEPINE

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS

AMINO-SUBSTITUTED TETRACYCLIC COMPOUNDS

PREVENTIVE AND/OR THERAPEUTIC AGENTS FOR BRONCHIAL ASTHMA

Preventive and/or therapeutic agents for bronchial asthma and tachykinin inhibitors, containing as the active ingredient tricyclic compounds represented by the general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 is hydrogen, halogeno, substituted or unsubstituted lower alkyl, or substituted or unsubstituted lower alkoxy; X1-X2-X3is CR5=CR6-CR7=CR8 (wherein R5, R6, R7 and R8 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like) or the like; Y is -CH2S-, -CH2SO-, -CH2SO2-, -CH2O-, -CH=CH-, -(CH2)p- (wherein p is an integer of 0 to 2), -SCH2-, -SOCH2-, -SO2CH2-, or -OCH2-; and R2 is hydrogen, substituted or unsubstituted lower alkyl, or the like.

Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof

6H-DIBENZ(B,F)THIEPIN COMPOUNDS

Heterocyclic amino acids

Compounds of formula I
in which:-
Y represents O, NRa, S, SO or SO2;
X1 represents (CR1R2)m;
X2 represents (CR3R4)n;
one of m and n is 1 and the other is 0 or 1; and Ra, R1, R2, R3 and R4 are each as defined in the specification; and non-toxic metabolically labile esters or amides thereof; and pharmaceutically acceptable salts thereof; are useful as modulators of metabotropic glutamate receptor function.

축합환 화합물 및 이를 포함한 유기 발광 소자

... 축합환 화합물 및 이를 포함한 유기 발광 소자가 개시된다.

BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

L'invention concerne des nouvelles benzothiépines, des dérivés et analogues de celles-ci, des procédés de préparation de tels composés, des compositions pharmaceutiques contenant ces composés ainsi que des méthodes d'utilisation de ces composés et compositions dans la préparation d'un médicament; elle concerne notamment des médicaments utiles dans la prophylaxie et le traitement d'états hyperlipidémiques, tels ceux associés à l'athérosclérose ou l'hypercholestérolémie, chez des mammifères.

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Production of aromatic compounds

Polycyclic aromatic compounds are prepared by heating a compound containing an aromatic nucleus, e.g. a diphenyl, phenyl or naphthyl nucleus, said nucleus having a sulphonyl halide group and a second aromatic nucleus linked ortho to the sulphonyl halide group, evolving sulphur dioxide and hydrogen halide, thus forming a bond between the carbon atom to which sulphonyl halide group was originally linked and a carbon atom of the second aromatic nucleus, being a carbon atom to which in the starting material, a hydrogen atom was bonded. The invention further comprises compounds of the general formula wherein X is -CH2- and R, R1 and R11 are hydrogen, aliphatic or aralkyl groups. The reaction takes place by heating the sulphonyl chloride or bromide to above 100 DEG C. in the liquid or vapour phase, optionally in the presence of a solvent, e.g. hexachlorobenzene or octachloronaphthalene and a catalyst, e.g. copper or copper halide as described in Specification 959,605. Specified ...

Excitatory amino acid derivatives

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.

TETRACYCLIC COMPOUNDS

1,2,3,4-TETRAHYDRO-TRIBENZO (B,D,F)-OXEPINE OR -THIEPINE

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Excitatory amino acid derivatives

6H-dibenz(b,f)thiepin compounds

Novel dibenz[b,f]thiepin derivatives have the formula



wherein n is 1 or 2;

the broken lines represent optional double bonds;

Z is thio, sulfinyl or sulfonyl;

each of R², R3 and R9, independently of the others, is a hydrogen or halogen atom or a nitro, lower alkyl, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkanoyl, hydroxy, lower alkoxy, lower acyloxy, lower alkylthio, trifluoromethylthio, lower alkylsulfinyl, lower alkylsulfonyl or trifluoromethyl radical, or R² and R3 together represent a doubly bonded oxygen; and

R1 is

(a) 5-tetrazoyl, 5-tetrazoylmethyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-¿3-pyrrolin-3-yl-2,5-dione or



-(CH2)m--R4

where m is 0, 1, 2, 3 or 4 and R4 is hydroxy, lower alkoxy, N,N-di(lower alkyl)aminolower alkoxy), lower hydroxyalkyl, lower carboxylalkoxy, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkylsulfonylamino, carboxy(lower alkyl) ...

BENZOTHIEPINEN MIT WIRKUNG ALS INHIBITOREN DES ILEUMGALLENSÄURETRANSPORTS UND DER TAUROCHOLATE-AUFNAHME

BIOLOGICALLY ACTIVE HETEROBICYCLIC HYDROXIMIDATES AND THIOLHYDROXIMIDATES AND CARBAMATE ESTER DERIVATIVES THEREOF

Insecticidal and nematocidal heterobicyclic hydroximinates, thiohydroximidates, and carbamate esters, composition, and method of use thereof

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. см. иллюстрацию в PDF-документе ...

Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. см. иллюстрацию в PDF-документе ...

BENZOTHEPINES MIT WIRKUNG ALS INHIBITOREN DES GALLENSÄURETRANSPORTS UND DER TAUROCHOLATE-AUFNAHME

6H-dibenz(b,f)thiepin compounds

Novel dibenz[b,f]thiepin derivatives have the formula wherein n is 1 or 2; the broken lines represent optional double bonds; Z is thio, sulfinyl or sulfonyl; each of R², R3 and R9, independently of the others, is a hydrogen or halogen atom or a nitro, lower alkyl, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkanoyl, hydroxy, lower alkoxy, lower acyloxy, lower alkylthio, trifluoromethylthio, lower alkylsulfinyl, lower alkylsulfonyl or trifluoromethyl radical, or R² and R3 together represent a doubly bonded oxygen; and R1 is (a) 5-tetrazoyl, 5-tetrazoylmethyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy-3-pyrrolin-3-yl-2,5-dione or -(CH2)m--R4 where m is 0, 1, 2, 3 or 4 and R4 is hydroxy, lower alkoxy, N,N-di(lower alkyl)aminolower alkoxy), lower hydroxyalkyl, lower carboxylalkoxy, amino, N-(lower alkyl)amino, N,N-di(lower alkyl)amino, lower alkylsulfonylamino, carboxy(lower alkyl)amino, carboxamido(lower alkyl)amino, 2-imino-3-methylthiazolidine, (lower acyloxy)-( ...

Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

This invention relates to novel benzothiepines, derivatives and analogs thereof, pharmaceutical compositions containing them and their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as is associated with atherosclerosis, or hypercholesterolemia, in mammals.

NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

PRODUCTION METHOD FOR BENZOTHIEPIN COMPOUND HAVING ACTIVITY AS INHIBITOR AGAINST ILEUM BILE ACID TRANSPORT AND LAUCHOROLIC ACID SALT UPTAKE

PROBLEM TO BE SOLVED: To provide a method for producing a novel benzothiepin compound or its derivative or analogue. SOLUTION: A pharmaceutical composition containing the novel bnzothiepin compound or its derivative or analogue is provided. The novel benzothiepin compound or its derivative or analogue and the composition containing the same are used for preparing a medicine used for preventing and treating especially atherosclerosis of mammals and hyperlipemia relating to hypercholesterolemia. COPYRIGHT: (C)2004,JPO&NCIPI ...

EXCITATORY AMINO ACID DERIVATIVES

La présente invention concerne des composés de formule (I) dans laquelle Y représente un atome d'oxygène, un groupe NRa¿, un atome de soufre S, un groupe SO ou SO¿2, X1¿ représente un groupe (CR1¿R2¿)m, X2¿ représente un groupe (CR3¿R4¿)n, un des m et n est égal à 1 et l'autre est égal à 0 ou à 1, et R1¿, R2¿, R3¿ et R4¿ sont chacun définis dans la spécification. L'invention concerne aussi des esters ou des amides labiles, à métabolisme non toxique, de ces composés, ainsi que leurs sels acceptables sur le plan pharmaceutique. Tous ces composés sont utiles comme modulateurs de la fonction récepteur glutamate métabotropique.

Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.

BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

In Formula 1, rings A1, A2, and A3 may each be independently a C5-C60 carbocyclic group or a C2-C30 heterocyclic group, and n1 to n3 may each be independently 0 or 1, provided that the sum of n1, n2, and n3 is 1. In addition, the descriptions of X1, L1 to L9, a1 to a9, Ar1 to Ar6, b1 to b6, R1 to R3, and c1 to c3 are as defined in the present specification.

Preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Methods are provided for preparing benzothiepines, derivatives, and analogs thereof, which have activity as inhibitors of ileal bile acid transport and taurocholate uptake.

NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

This invention relates to novel benzothiepines, derivatives and analogs thereof, pharmaceutical compositions containing them and their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as is associated with atherosclerosis, or hypercholesterolemia, in mammals.

BENZOTHIEPINEN MIT WIRKUNG ALS INHIBITOREN DES ILEUMGALLENSÄURETRANSPORTS UND DER TAUROCHOLATE-AUFNAHME

NYA FORENINGAR TILL ANVENDNING SOM MELLANPRODUKTER VID FRAMSTELLNING AV AMINOSUBSTITUERADE TETRACYKLISKA FORENINGAR

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

6-H dibenz[b,f]thiepin compounds

Novel dibenz[b,f]thiepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma.

CONDENSED RING COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME

Disclosed are a condensed ring compound and an organic light emitting device comprising the same. According to another aspect, the organic light emitting device is provided, and includes: a first electrode; a second electrode facing the first electrode; and an organic layer interposed between the first electrode and the second electrode and having a light emitting layer. COPYRIGHT KIPO 2019 ...

HIDROXIMIDATO E TIOL-HIDROXIMIDATOS HETEROBICICLICOS E SEUS DERIVADOS ESTER -CARBAMATO COM ATIVIDADE BIOLOGICA

AMINSUBSTITUIERTE TETRACYCLISCHE VERBINDUNGEN

COMPOSITION, PHARMACEUTICAL COMPOSITION, METHODS PARAA PROPHYLAXIS OR TREATMENT OF A CONDIÇÃOHIPERLIPIDÊMICA, A CONDITION ATEROSCLERÓTICA EDE HIPERCOLESTEROLEMIA, USE OF A COMPOSITION EPROCESSO FOR THE PREPARATION OF A COMPOSITION

HIDROXIMIDATO AND TIOL-HIDROXIMIDATOS HETEROBICICLICOS AND ITS DERIVATIVES ESTER - CARBAMATO WITH BIOLOGICAL ACTIVITY

"New [...] having activity as inhibitors of transport of bile acid uptake and [...][...]"

BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

Novel benzothiepines, derivatives and analogs thereof; method of preparing such compounds; pharmaceutical compositions containing such compounds; and methods of using these compounds and compositions in the preparation of medicaments, particularly medicaments for use in the prophylaxis and treatment of hyperlipidemic conditions, such as those associated with atherosclerosis or hypercholesterolemia, in mammals. 156 claims ...

SETT ATT FRAMSTELLA AMINOSUBSTITUERADE TETRACYKLISKA FORENINGAR

Combination therapy employing ileal bile acid transport inhibiting benzothiepiens and HMG Co-A reductase inhibitors

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.

Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. ...

SUBSTITUTED OXEPINES

The invention relates to materials, to electroluminescence devices comprising said materials and to the use thereof.

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals. Also provided are compositions and methods for combination therapy employing ileal bile acid transport inhibitors and HMG Co-A reductase inhibitors for the treatment of hyperlipidemic conditions.

COMPOSE TETRACYCLIQUES AMINO-SUBSTITUES

"Novas benzotiepinas tendo atividade como inibidores de transporte do ácido biliar ileal e absorção de taurocolato"

COMPOSE TETRACYCLIQUES AMINO-SUBSTITUES

Novel benzothiepines having activities as inhibitors of ileal bile acid transport and taurocholate uptake

本发明涉及新的苯并硫杂䓬，它们的衍生物和类似物，含有它们的药物组合物及其在医学中的应用，特别是用于预防和治疗哺乳动物的高脂血症，例如与动脉粥样硬化有关的病症，或高胆固醇血症。

COMPOSED DERIVATIVE OF BENZOTIEPINA, PHARMACEUTICAL COMPOSITION CONTAIN THAT IT, METHOD FOR THE PROPHYLAXIS OR TREATMENT OF AN AFFECTION HIPERLIPIDEMICA, USE OF THAT COMPOUND AND PROCESSES FOR THE PREPARATION OF THE SAME

El derivado de benzotiepina responde a la formula (I) donde: q es un numero entero de 1 a 4; n es un numero entero de 0 a 2; R1 y R2 se seleccionanindependientemente del grupo formado por H, alquilo, alquenilo, alquinilo, haloalquilo, alquilarilo, arilalquilo, alcoxi, alcoxialquilo, dialquilamino,alquiltio, (polialquil)arilo, y cicloalquilo, donde el alquilo, alquenilo, alquinilo, haloalquilo, alquilarilo, arilalquilo, alcoxi, alcoxialquilo,dialquilamino, alquiltio, (polialquil)arilo, y cicloalquilo está sustituido opcionalmente con uno o más sustituyentes seleccionados del grupo formado por OR9,NR9R10, N+R9R10RwA-, SR9, S+R9R10A-, P+R9R10R11A-, S(O)R9, SO2R9, SO3R9, CO2R9, CN, halogeno, oxo, y CONR9R10, donde el alquilo, alquenilo, alquinilo,alquilarilo, alcoxi, alcoxialquilo, (polialquil)arilo, y cicloalquilo poseen opcionalmente uno o más carbonos sustituidos por O, NR9, n+R9R10A-, S, SO, SO2,S+R9A-, P+R9R10A-, o fenileno, donde R9, R10, y Rw se seleccionan independientemente del grupo ...

Novel benzothiepines having activity as inhibitors of lleal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE

Preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Methods are provided for preparing benzothiepines, derivatives, and analogs thereof, which have activity as inhibitors of ileal bile acid transport and taurocholate uptake.

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as those associated with atherosclerosis or hypercholesterolemia, in mammals.

CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

In Formula 1, rings A1, A2, and A3 may each be independently a C5-C60 carbocyclic group or a C2-C30 heterocyclic group, and n1 to n3 may each be independently 0 or 1, provided that the sum of n1, n2, and n3 is 1. In addition, the descriptions of X1, L1 to L9, a1 to a9, Ar1 to Ar6, b1 to b6, R1 to R3, and c1 to c3 are as defined in the present specification.

Substituted oxepines

본 발명은 물질, 상기 물질을 포함하는 전계발광 소자 및 이의 용도에 관한 것이다. The present invention relates to materials, to electroluminescent devices comprising said materials and to uses thereof.

Substituted oxepines

The invention relates to materials, to electroluminescence devices comprising said materials and to the use thereof.

Process for producing heterocyclic hydroximidates and thiohydroximidates and their carbamate-ester derivatives

Novel benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described.

2-KETO-1,2,3,4-TETRAHYDRO-TRIBENSO (B, D, F) -AZEPINES, -OXEPINES, -TIEPINES OR -CYCLOHEPTATRINES FOR USE AS INTERMEDIATE PRODUCTS OF THE COMPARATIVE EQUIPMENT 2

Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof.

Novel heterobicyclic compounds of Formula I, processes for preparing same and pesticidal compositions and methods are described. <CHEM contiene="yes"> i

Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake

Substituted oxepines

The invention relates to materials, to electroluminescence devices comprising said materials and to the use thereof.

유기 화합물 및 이를 포함하는 유기 전계 발광 소자

본 발명은 신규 화합물 및 이를 포함하는 유기 전계 발광 소자에 관한 것으로서, 본 발명에 따른 화합물은 유기 전계 발광 소자의 유기물층, 바람직하게는 발광층, 전자 수송층, 정공 수송층 또는 전자 수송 보조층에 사용됨에 따라 유기 전계 발광 소자의 발광 효율, 구동 전압, 수명 등을 향상시킬 수 있다.

稠环化合物和包括该稠环化合物的有机发光装置

本公开提供一种稠环化合物和包含该稠环化合物的有机发光装置。所述有机发光装置包括第一电极、第二电极以及设置在第一电极和第二电极之间的有机层。所述有机层包括由式1表示的稠环化合物：<式1> 在式1中，环A 1 、环A 2 和环A 3 可各自独立地为C 5 ‑C 60 碳环基团或C 1 ‑C 60 杂环基团，并且n1至n3可各自独立地为0或1，前提是n1、n2与n3的总和为1。另外，X 1 、L 1 至L 9 、a 1 至a 9 、Ar 1 至Ar 6 、b 1 至b 6 、R 1 至R 3 和c 1 至c 3 的描述如本说明书中所定义。

Benzothiepinen mit wirkung als inhibitoren des ileumgallensäuretransports und der taurocholate- aufnahme

一种芴衍生物、电子元件和电子装置

本发明涉及有机电致发光材料技术领域，尤其涉及一种芴衍生物及其在电子元件和电子装置中的应用。所述芴衍生物的结构式如式(I)所示；本发明提供的式(I)所示化合物，具有七元环及以上多元环结构。将该化合物应用在有机电致发光元件中，可显著降低驱动电压、提高发光效率和寿命；

縮合環化合物、及びそれを含む有機発光素子

【課題】縮合環化合物、及びそれを含んだ有機発光素子を提供する。【解決手段】下記化学式１で表示される縮合環化合物：【化１】TIFF2023054078000268.tif60164該化学式１で、Ｘ1、環Ａ1、Ａ2及びＡ3、Ｌ1からＬ9、ａ１からａ９、Ａｒ1からＡｒ6、ｂ１からｂ６、Ｒ1からＲ5、ｃ１からｃ３、ｎ１からｎ３については、詳細な説明を参照する。【選択図】図１

화합물 및 이를 이용한 유기전기소자

본 발명의 실시예들은 높은 발광효율, 낮은 구동전압, 고내열성, 색순도, 또는 수명을 향상시킬 수 있는 유기전기소자용 화합물 및 이를 이용한 유기전기소자에 관한 것이다.

화합물 및 이를 이용한 유기전기소자

본 발명의 실시예들은 높은 발광효율, 낮은 구동전압, 고내열성, 색순도, 또는 수명을 향상시킬 수 있는 유기전기소자용 화합물 및 이를 이용한 유기전기소자에 관한 것이다.

Condensed cyclic compound and organic light-emitting device including the same

一種有機化合物及其應用

本發明涉及一種有機化合物及其應用。所述有機化合物具有式（1）所示的結構。本發明化合物具有較低LUMO能級，製備的紅光器件的驅動電壓低，更好的器件發光效率和改善的壽命。研究結果表明本發明化合物作爲空穴注入層材料，可用於有機電致發光器件中，具有應用於OLED産業的可能。

Benzothepines mit wirkung als inhibitoren des gallensäuretransports und der taurocholate- aufnahme

稠环化合物和包括该稠环化合物的有机发光装置

本公开提供一种稠环化合物和包含该稠环化合物的有机发光装置。所述有机发光装置包括第一电极、第二电极以及设置在第一电极和第二电极之间的有机层。所述有机层包括由式1表示的稠环化合物：<式1> 在式1中，环A 1 、环A 2 和环A 3 可各自独立地为C 5 ‑C 60 碳环基团或C 1 ‑C 60 杂环基团，并且n1至n3可各自独立地为0或1，前提是n1、n2与n3的总和为1。另外，X 1 、L 1 至L 9 、a 1 至a 9 、Ar 1 至Ar 6 、b 1 至b 6 、R 1 至R 3 和c 1 至c 3 的描述如本说明书中所定义。

유기 화합물 및 그 응용

본 발명은 유기 화합물 및 그 응용에 관한 것이다. 상기 유기 화합물은 식(1)로 표시되는 구조를 가진다. 상기 화합물은 낮은 LUMO 에너지 준위를 가지며, 제조된 적색 광 소자의 구동 전압이 낮고, 소자의 발광 효율이 더 우수하고 수명이 개선된 장점이 있다. 이상 결과는 본 발명의 화합물이 유기 전계 발광 소자에서 정공 주입층 재료로 사용될 수 있으며 OLED 산업에 적용될 수 있는 가능성을 가지고 있음을 보여준다.

一種有機化合物及其應用

本發明涉及一種有機化合物及其應用。所述有機化合物具有式（1）所示的結構。本發明化合物具有較低LUMO能級，製備的紅光器件的驅動電壓低，更好的器件發光效率和改善的壽命。研究結果表明本發明化合物作爲空穴注入層材料，可用於有機電致發光器件中，具有應用於OLED産業的可能。

Organic compound and electroluminescent device

The present disclosure relates to an organic compound and an electroluminescent device. The organic compound has the structure as shown in formula (1), which can be used in an organic electroluminescent device as a hole injection layer material.

一种芴衍生物、电子元件和电子装置

本发明涉及有机电致发光材料技术领域，尤其涉及一种芴衍生物及其在电子元件和电子装置中的应用。所述芴衍生物的结构式如式(I)所示；本发明提供的式(I)所示化合物，具有七元环及以上多元环结构。将该化合物应用在有机电致发光元件中，可显著降低驱动电压、提高发光效率和寿命；

一种有机化合物及其应用

本发明涉及一种有机化合物及其应用。所述有机化合物具有式(1)所示的结构。本发明化合物具有较低LUMO能级，制备的红光器件的驱动电压低，更好的器件发光效率和改善的寿命。上述结果表面本发明化合物作为空穴注入层材料，可用于有机电致发光器件中，具有应用于OLED产业的可能。

稠环化合物和包括该稠环化合物的有机发光装置

本公开提供一种稠环化合物和包含该稠环化合物的有机发光装置。所述有机发光装置包括第一电极、第二电极以及设置在第一电极和第二电极之间的有机层。所述有机层包括由式1表示的稠环化合物：<式1> 在式1中，环A 1 、环A 2 和环A 3 可各自独立地为C 5 ‑C 60 碳环基团或C 1 ‑C 60 杂环基团，并且n1至n3可各自独立地为0或1，前提是n1、n2与n3的总和为1。另外，X 1 、L 1 至L 9 、a 1 至a 9 、Ar 1 至Ar 6 、b 1 至b 6 、R 1 至R 3 和c 1 至c 3 的描述如本说明书中所定义。

稠环化合物和包括该稠环化合物的有机发光装置

本公开提供一种稠环化合物和包含该稠环化合物的有机发光装置。所述有机发光装置包括第一电极、第二电极以及设置在第一电极和第二电极之间的有机层。所述有机层包括由式1表示的稠环化合物：<式1> 在式1中，环A 1 、环A 2 和环A 3 可各自独立地为C 5 ‑C 60 碳环基团或C 1 ‑C 60 杂环基团，并且n1至n3可各自独立地为0或1，前提是n1、n2与n3的总和为1。另外，X 1 、L 1 至L 9 、a 1 至a 9 、Ar 1 至Ar 6 、b 1 至b 6 、R 1 至R 3 和c 1 至c 3 的描述如本说明书中所定义。

新型含螺化合物及其在有机电致发光器件中的应用

本发明涉及有机电致发光材料领域，具体为新型含螺化合物及其在有机电致发光器件中的应用，本发明提供的新型含螺化合物具有非常好的空穴迁移率、良好的热稳定性且不易结晶，可作为空穴传输层材料有效应用于有机电致发光器件的制备；本发明提供的新型含螺化合物具有良好的电子传输性能，且能够与空穴传输材料进行良好的搭配，形成良好的空穴‑电子平衡，达到效率和发光寿命的最佳状态，可作为电子传输层材料有效应用于有机电致发光器件的制备；本发明提供的新型含螺化合物具有合适的能级、能够形成良好的能量传递，且具有高度的化学稳定性，可作为发光主体层材料有效应用于有机电致发光器件的制备。

有机电致发光化合物及包含其的有机电致发光装置

本公开涉及一种由式1表示的有机电致发光化合物以及一种包含所述有机电致发光化合物的有机电致发光装置。通过包含本公开的有机电致发光化合物，可以提供具有改善的驱动电压和/或发光效率特征的有机电致发光装置。

新型含螺化合物及其在有机电致发光器件中的应用

本发明涉及有机电致发光材料领域，具体为新型含螺化合物及其在有机电致发光器件中的应用，本发明提供的新型含螺化合物具有非常好的空穴迁移率、良好的热稳定性且不易结晶，可作为空穴传输层材料有效应用于有机电致发光器件的制备；本发明提供的新型含螺化合物具有良好的电子传输性能，且能够与空穴传输材料进行良好的搭配，形成良好的空穴‑电子平衡，达到效率和发光寿命的最佳状态，可作为电子传输层材料有效应用于有机电致发光器件的制备；本发明提供的新型含螺化合物具有合适的能级、能够形成良好的能量传递，且具有高度的化学稳定性，可作为发光主体层材料有效应用于有机电致发光器件的制备。

稠环化合物和包括该稠环化合物的有机发光装置

本公开提供一种稠环化合物和包含该稠环化合物的有机发光装置。所述有机发光装置包括第一电极、第二电极以及设置在第一电极和第二电极之间的有机层。所述有机层包括由式1表示的稠环化合物： 在式1中，环A 1 、环A 2 和环A 3 可各自独立地为C 5 ‑C 60 碳环基团或C 1 ‑C 60 杂环基团，并且n1至n3可各自独立地为0或1，前提是n1、n2与n3的总和为1。另外，X 1 、L 1 至L 9 、a 1 至a 9 、Ar 1 至Ar 6 、b 1 至b 6 、R 1 至R 3 和c 1 至c 3 的描述如本说明书中所定义。