23-05-2013 дата публикации
Номер: US20130131070A1
Принадлежит:
Provided are 1-aryl or 1-heteroaryl substituted beta-carboline compounds or indole analogs thereof having the structure: 2. The substituted β-carboline compound of claim 1 ,wherein X is NH;{'sup': '1', 'Ris 1-naphthyl optionally substituted with Br or F; and'}{'sup': 2', '3', '4', '5', '6', '7, 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4, 'R, R, R, R, R, and Rare independently H, OH, halogen, CN, C-Calkyl, C-Calkoxy, C-Chaloalkoxy, —C(O)OC-Cester, —(C-C)—SO—NH—(C-C) sulfonamide, or phenyl;'}{'sup': 5', '6', '7', '2', '3', '4', '5', '6', '7', '2', '3', '4', '5', '6', '7, 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4, 'wherein, when one of R, R, or Ris C-Calkoxy, then R, R, R, R, R, and Rare independently H, OH, halogen, CN, C-Chaloalkoxy, —C(O)OC-Cester, —C-C—SO—NH—C-Csulfonamide, or phenyl such that at least two of R, R, R, R, R, and Rare other than H.'}3. The substituted β-carboline compound of claim 1 ,wherein X is NH;{'sup': '1', 'Ris 1-dihydroacenaphthenyl optionally substituted with Br or F; and'}{'sup': 2', '3', '4', '5', '6', '7, 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4, 'R, R, R, R, R, and Rare independently H, OH, halogen, CN, C-Calkyl, C-Calkoxy, phenyl, C-Chaloalkoxy, —C(O)OC-Cester, —(C-C)—SO—NH—(C-C) sulfonamide, or phenyl.'}4. The substituted β-carboline compound of claim 1 ,{'sub': '3', 'wherein X is N—CH, S, or O;'}{'sup': '1', 'Ris 1-naphthyl or 1-dihydroacenaphthenyl each optionally substituted with Br or F; and'}{'sup': 2', '3', '4', '5', '6', '7, 'sub': 1', '4', '1', '4', '1', '4', '1', '4', '1', '4', '2', '1', '4, 'R, R, R, R, R, and Rare independently H, OH, halogen, CN, C-Calkyl, C-Calkoxy, phenyl, C-Chaloalkoxy, —C(O)OC-Cester, —C-C—SO—NH—C-Csulfonamide or phenyl.'}5. A pharmaceutical composition comprising the substituted β-carboline compound of and a pharmaceutically effective carrier.6. A method for inhibiting proliferation of cells associated with a cell proliferative ...
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