17-10-2013 дата публикации
Номер: US20130273037A1
Принадлежит:
Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections. 2. The compound of wherein:{'sup': 1', '2', '3', '8′', '4', '5', '2′', '2', '1', '2', '3', '4', '5', '2′, 'a) Yis N, NH or CH, Yis C, Yis N or CR, Yis N or C and Yis N, NR or CR, wherein at least two of Y, Y, Y, Yand Yare independently N, NH or NR; or'}{'sup': 1', '2', '3', '8′', '4', '5', '2′', '1', '2', '3', '4', '5', '2′, 'b) Yis N, NH or CH, Yis N or C, Yis N or CR, Yis N or C, and Yis N or NR, wherein at least two of Y, Y, Y, Yand Yare independently N, NH or NR; or'}{'sup': 1', '2', '3', '8′', '4', '5', '2′', '2', '1', '2', '3', '4', '5', '2′, 'c) Yis N, NH or CH, Yis N or C, Yis CR, Yis N or C, and Yis N, NR or CR, wherein at least two of Y, Y, Y, Yand Yare independently N, NH or NR;'}the dashed bonds ---- are selected from single bonds and double bonds so as to provide an aromatic ring system;{'sup': 4', '4′', '4', '4′', '4', '4′', 'a, 'sub': n', 'n', 'p, 'A is —(CRR)— wherein any one CRR of said —(CRR)— may be optionally replaced with —O—, —S—, —S(O)—, NH or NR;'}n is 3, 4, 5 or 6;each p is 1 or 2;{'sub': 2', '20', '6', '20', '2', '20', '6', '20, 'sup': '6', 'Ar is a C-Cheterocyclyl group or a C-Caryl group, wherein the C-Cheterocyclyl group or the C-Caryl group is optionally substituted with 1 to 5 R;'}{'sup': 13', '14', '14, 'sub': '2', 'X is —C(R)(R)—, —N(CHR)— or —NH—, or X is absent;'}{'sup': 1', '11', '11', '12', '11', '11', '11', '11', '11', '11', '12', '11', 'a', '11', 'a', '11', '11', '11', '12', '11', '11', '11', '12', '11', '11', '11', '11', '12', '11', '11', '11', '12, 'sub': 3', '2', 'p', 'p', 'p', '2', 'p', 'p', '1', '8', '2', '8', '2', '8', '1', '8', '6', '20', '2', '20', '2', '20', '1', '8', ...
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