18-02-2016 дата публикации
Номер: US20160046581A1
The present invention provides a compound of Formula (I) 2. A compound of or a pharmaceutically acceptable salt thereof claim 1 , where [{'sup': 3', '3', '4, '1) 6-membered monocyclic carbocycle unsubstituted or mono-substituted with Ror di-substituted with Rand R,'}, {'sup': 3', '3', '4, '2) 5 or 6 membered monocyclic heterocycle having 1 or 2 N atoms and unsubstituted or mono-substituted with Ror di-substituted with Rand R,'}, {'sup': '3', '3) 10-membered bicyclic carbocycle unsubstituted or substituted with R, or'}, {'sup': '3', '4) 10-membered bicyclic unsubstituted heterocycle having 1 N atom and unsubstituted or substituted with R;'}], 'A is'}{'sup': '1', 'claim-text': [{'sub': '1-6', '1) Calkyl,'}, {'sup': '7', '2) 6-membered monocyclic carbocycle unsubstituted or substituted with R, or'}, {'sup': 3', '3', '4, '3) 5- or 6-membered monocyclic heterocycle having one, two or three heteroatoms, wherein the heteroatoms are selected from the group of 1-2 N atoms and 1 O atom, and unsubstituted or mono-substituted with Ror di-substituted with Rand R;'}], 'Ris'}{'sup': '1a', 'sub': '3', 'Ris H or CH;'}{'sup': '2', 'claim-text': [{'sup': '8', '1) —C(O)NHR,'}, {'sub': 2', '2, 'sup': '10', '2) —C(O)N(CHR)(CHR),'}, {'sup': '11', '3) —C(O)R,'}, {'sup': '18', '4) 5-membered heterocycle having 1-3 heteroatoms and unsubstituted or substituted with R;'}, {'sup': '18', '5) 9-membered bicyclic heterocycle having 1-3 heteroatoms and unsubstituted or substituted with R; or'}, {'sup': '18', '6) 13 or 14-membered tricyclic heterocycle having 1-3 heteroatoms and unsubstituted or substituted with R;'}], 'Ris'}{'sup': 3', '4, 'claim-text': [{'sub': '2', '1) —C(NH)NH,'}, {'sub': '2', '2) —NH,'}, '3) Halogen,', {'sub': 1-6', '2, '4) —Calkyl, unsubstituted or substituted with —OH, F or —NH,'}, {'sub': '1-6', '5) —C(O)OCalkyl,'}, {'sub': '3', '6) —CF,'}, {'sup': 5', '5', '6, '7) 5-membered heterocycle with 1-4 N atoms which is unsubstituted or mono-substituted with Ror di-substituted with ...
Подробнее