06-09-2018 дата публикации
Номер: US20180251483A1
Принадлежит:
Described herein, inter alia, are thiocyanate salt compositions and methods for treating or preventing inflammation using the same. 2. The salt of claim 1 , wherein the metal is selected from the group consisting of manganese claim 1 , iron claim 1 , cobalt claim 1 , copper claim 1 , nickel claim 1 , and zinc.3. (canceled)5. The salt of claim 4 , wherein Ris C-Calkyl.7. The salt of claim 6 , wherein Ris C-Calkyl and Rand Rare each unsubstituted ethyl.8. (canceled)9. The salt of claim 8 , wherein A is hydrogen.12. (canceled)13. (canceled)14. The salt as in claim 11 , wherein Xis R-substituted or unsubstituted alkyl;{'sup': 13', '14', '14', '14', '14', '14, 'sub': 2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3, 'Ris halogen, —NH, —CF, —CHF, —CHF, —CN, —SOCl, —SH, —SONH, —NHNH, —ONH, —NHC(O)NHNH, —NHC(O)N H, —NO, —C(O)H, —C(O)OH, —C(O)NH, —OH, —NHSOH, —NHC (O)H, —NHC(O)OH, —NHOH, —OCF, oxo, —N, R-substituted or unsubstituted heteroalkyl, R-substituted or unsubstituted cycloalkyl, R-substituted or unsubstituted heterocycloalkyl, R-substituted or unsubstituted aryl, or an R-substituted or unsubstituted heteroaryl; and'}{'sup': '14', 'sub': 2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3, 'Ris halogen, —NH, —CF, —CHF, —CHF, —CN, —SOCl, —SH, —SONH, —NHNH, —ONH, —NHC(O)NHNH, —NHC(O)N H, —NO, —C(O)H, —C(O)OH, —C(O)NH, —OH, —NHSOH, —NHC(O)H, —NHC(O)OH, —NHOH, —OCF, oxo, —N, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl.'}15. The salt of claim 14 , wherein Ris C-Calkyl.16. The salt as in claim 11 , wherein Xis Calkyl.17. The salt of claim 16 , wherein A is hydrogen.18. A pharmaceutical composition comprising a salt of and a pharmaceutically acceptable excipient.19. A method of treating inflammation in a subject in need thereof claim 1 , comprising administering to said subject an effective amount of a salt of .20 ...
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