12-01-2012 дата публикации
Номер: US20120009121A1
Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described. 423-. (canceled)25. (canceled)26. A compound according to claim 1 , having a chelated metal claim 1 , wherein the chelated metal is Tc claim 1 , In claim 1 , Ga claim 1 , Y claim 1 , Lu claim 1 , Re claim 1 , Cu claim 1 , Ac claim 1 , Bi claim 1 , Pb claim 1 , Sm claim 1 , Sc claim 1 , Co claim 1 , Ho claim 1 , Gd claim 1 , Eu claim 1 , Tb claim 1 , or Dy.27. (canceled)28. A compound according to wherein the metal is a radioactive isotope and wherein the isotope is Tc-94m claim 26 , Tc-99m claim 26 , In-111 claim 26 , Ga-67 claim 26 , Ga-68 claim 26 , Y-86 claim 26 , Y-90 claim 26 , Lu-177 claim 26 , Re-186 claim 26 , Re-188 claim 26 , Cu-64 claim 26 , Cu-67 claim 26 , Co-55 claim 26 , Co-57 claim 26 , Sc-47 claim 26 , Ac-225 claim 26 , Bi-213 claim 26 , Bi-212 claim 26 , Pb-212 claim 26 , Sm-153 claim 26 , Ho-166 claim 26 , or Dy-166.3244-. (canceled)46. (canceled)47. A compound according to having a chelated metal ion claim 30 , wherein the chelated metal ion is Tc claim 30 , Re claim 30 , Cu claim 30 , or Ga.48. A compound according to wherein the metal ion is Tc-99m claim 47 , Re-186 claim 47 , Re-188 claim 47 , Cu-64 claim 47 , or Ga-68.49. (canceled)5274-. (canceled)75. A compound according to wherein FG is a fluorescent dye moiety which emits in the near infrared spectrum.76. A compound according to wherein FG comprises carbocyanine claim 1 , indocarbocyanine claim 1 , oxacarbocyanine claim 1 , thiacarbocyanine and merocyanine claim 1 , polymethine claim 1 , coumarine claim 1 , rhodamine claim 1 , xanthene claim 1 , fluorescein claim 1 , boron-dipyrromethane (BODIPY) claim 1 , Cy5 claim 1 , Cy5.5 claim 1 , Cy7 claim 1 , VivoTag-680 claim 1 , VivoTag-S680 claim 1 , VivoTag-S750 claim 1 , AlexaFluor660 claim 1 , AlexaFluor680 claim 1 , AlexaFluor700 claim 1 , AlexaFluor750 claim 1 , ...
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