04-04-2013 дата публикации
Номер: US20130085107A1
The present invention provides peptides that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms. 183-. (canceled)84. A peptide or a pharmaceutically acceptable salt thereof , wherein the peptide comprises the amino acid sequence{'sub': 1', '2', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12', '13', '14', '15', '16', '17, 'XaaXaaXaaXaaCysXaaXaaXaaCysAsnProAlaCysXaaGlyXaaXaa, or a pharmaceutically acceptable salt thereof; wherein'}{'sub': '1', 'Xaais Asn, D-Asn, Gln, D-Gln, Pro, Ala, n-Ala, D-Ala, Val, D-Val, Gly, Thr, D-Thr, Asp, D-Asp, γ-carboxylated Asp, Glu, D-Glu, γ-carboxylated Glu, α-aminosuberic acid (Asu), α-aminoadipic acid (Aad), α-aminopimelic acid (Apm), or is absent;'}{'sub': '2', 'Xaais Asp, γ-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm, or is absent;'}{'sub': '3', 'Xaais Asp, γ-carboxylated Asp, Glu, γ-carboxylated Glu, Asu, Aad, Apm, or is absent;'}{'sub': '4', 'Xaais Cys or D-Cys;'}{'sub': '6', 'Xaais P-Ser, P-Thr, P-homo-Ser, 4-hydroxyvaline phosphate, P-homo-Thr, P-Cys or P-Tyr;'}{'sub': '7', 'Xaais Tyr, Leu, Phe or Ile;'}{'sub': '8', 'Xaais Cys or D-Cys;'}{'sub': '14', 'Xaais Thr, Ala or Phe;'}{'sub': '16', 'Xaais Cys or D-Cys; and'}{'sub': '17', 'Xaais Tyr, D-Tyr, or is absent;'}wherein:{'sub': 1', '1, 'if Xaais present, Xaamay be modified on its amino group by methyl, ethanedioic acid, propanedioic acid, butanedioic acid, pentanedioic acid, hexanedioic acid, heptanedioic acid or octanedioic acid;'}{'sub': 1', '2', '2, 'if Xaais absent and Xaais present, then Xaamay be modified on its amino group by methyl, ethanedioic acid, propanedioic acid, butanedioic acid, pentanedioic acid, hexanedioic acid, heptanedioic acid or octanedioic acid; or'}{'sub': 1', '2', '3, 'if both Xaaand Xaaare ...
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