СПОСОБ ПОЛУЧЕНИЯ БИОРАЗЛАГАЕМОГО СОПОЛИМЕРА СЛОЖНОГО ПОЛИЭФИРА И ПРОСТОГО ЭФИРАМИДА

Изобретение относится к области промышленных способов получения биоразлагаемого сополимера сложного полиэфира и простого эфирамида. Предложен способ получения биоразлагаемого сополимера сложного полиэфира и простого эфирамида, включающий этап реакции этерификации и/или переэтерификации и амидирования, этап предварительной поликонденсации, этап поликонденсации, необязательный этап экстракции, этап сушки и заключительный этап экструзии с добавками. Технический результат – предложенный способ позволяет выпускать сополимер с широким диапазоном вязкости, а также с различным содержанием добавок и улучшить цвет продукта, являясь одновременно более экологически чистым и более безопасным для всего обслуживающего персонала по сравнению с имеющимися аналогами. 11 з.п. ф-лы, 1 ил., 1 табл., 9 пр.

Strahlenhärtbare Urethan-Acrylatprepolymere und vernetzte Polymere

Aus bioabbaubaren Kunststoffen hergestellte eine färbende Flüssigkeit enthaltende Markierungsvorrichtung

Bioabbaubare Polyesterurethane, Verfahren zu ihrer Herstellung sowie ihre Verwendung

The invention relates to biodegradable linear polyester urethanes and to biodegradable cross-linked polyester urethanes obtained from linear polyester urethanes by virtue of the fact that they are cross-linked by diisocyanate bridges. By varying the degree of crosslinking, the physical, chemical and biological properties of the inventive cross-linked polyester urethane can be adjusted and the biodegradability thereof can also be varied considering that biological degradability occurs more slowly as the degree of crosslinking increases. The invention also relates to a method for producing the inventive polyester urethanes and to the use thereof as films, rubber bodies, containers, packaging materials and in galenical preparations, as adhesives, adhesive strips and the like. The invention also relates to polymer blends containing the inventive polyurethanes.

Bioabbaubare Polyesterurethane, Verfahren zu ihrer Herstellung sowie ihre Verwendung

Biologisch abbaubare Polyurethane.

Biologically-degradable polyester mixture, useful for the production of plastic parts, foils or fibers, comprises polyester; homo or co-polyester; epoxide-containing copolymer; additive; and inorganic or organic fillers

Biologically-degradable polyester mixture (A) comprises at least one polyester (5-80 wt.%); at least one biologically-degradable homo or co-polyester (20-95 wt.%); 0.1-15 wt.% of: an epoxide-containing copolymer made from styrol, acrylate ester and/or methacrylate ester, biphenol-A-epoxide or an epoxide-containing natural oil, fatty acid ester or fatty acid amide; additive (0-15 wt.%); and inorganic or organic fillers (0-50 wt.%). Biologically-degradable polyester mixture (A) comprises (a) at least one polyester (5-80 wt.%, based on the total weight of (a) and (b)) made from aliphatic and aromatic dicarboxylic acids and aliphatic dihydroxy compounds; (b) at least one biologically-degradable homo or co-polyester (20-95 wt.%, based on the total weight of (a) and (b)) such as polylactides, polycaprolactones, polyhydroxyalkanoates or polyesters made from aliphatic dicarboxylic acids and aliphatic diols; (c) 0.1-15 wt.%, based on the total weight of components (a) and (b), of: an epoxide-containing ...

Blends enthaltende Cellulosederivate und ausgewählte Polymere

The invention relates to blends containing cellulose esters and/or cellulose ethers and selected polymers which are also biologically degradable and, optionally, plasticizers.

Biodegradable composite material and process of producing same

A biodegradable composite material includes a solid body of a natural polyhydroxy polymer, and a polyurethane or a polymer of a vinyl monomer bonded to the solid body by reaction with part of the hydroxyl groups of the polyhydroxy polymer. The polyurethane or the polymer of a vinyl monomer is present in an amount of at least 10 % based on the weight of the solid body. The polyurethane-containing composite material is produced by reacting the solid body with a reaction solution of a polyisocyanate and a polyol compound. The natural polymer may be selected from cellulose, hemicellulose, lignocellulose, lignin and starch. The solid body may be in the form of a fibre, powder, film, sheet plate, block, pellet or rod. The composite material may be a foamed body wherein the solid body is in powder or fibre form. The vinyl monomer is graft polymerised onto the solid body.

BLENDS WITH FORM MEMORY CHARACTERISTICS

FINALDIGIT HYDROXYL EXHIBITING POLYHYDROXYALKANOATE

DEGRADABLE ONE, ON POLYDIOXANON BASED MATERIALS

INTERLACED POLYCYCLOOCTEN

BIOLOGICALLY DEGRADABLE ONES POLYMER COMPOSITIONS, THE STRENGTH AND A THERMOPLASTIC POLYMER CONTAINING

Polymerstruktur und dreidimensionales Gerüst für die Gewebezüchtung

The invention relates to a polymer for tissue engineering composed of biodegradable polyphosphazenes with photopolymerizable side groups, wherein the side groups of the polyphosphazenes are exclusively formed of amino acids and/or amino acid derivatives, wherein said side groups are bound to the backbone of the polyphosphazene via the amino group of the amino acid, and comprising a spacer bound to the acid group having a carbon chain of length m which comprises a vinyl group at its free end, wherein m = 0 to 10.

BIOLOGISCGH ABBAURE POLYMER COMPOSITIONS, THE STRENGTH AND A THERMOPLASTIC POLYMER CONTAINING

BIOLOGICALLY DEGRADABLE ONES AND KOMPOSTIERBARE MOLDED ARTICLES INCLUSIVELY PLANAR FORMATIONS

BIOLOGICALLY DEGRADABLE ONES OF POLYMERS, PROCEDURES FOR THEIR PRODUCTION AS WELL AS THEIR USE FOR THE PRODUCTION OF BIODEGRADABLE MOLDED ARTICLES

BIOLOGICALLY DEGRADABLE ONES OF POLYMERS, PROCEDURES FOR THEIR PRODUCTION AS WELL AS THEIR USE FOR THE PRODUCTION OF BIODEGRADABLE MOLDED ARTICLES

STOFFZUSAMMENSETZUNG FOR FABRIC FORMATION

FUSIONSTABLE LACTIDPOLYMERGEWEBE AND PROCEDURE FOR ITS PRODUCTION

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

BLENDS WITH FORM MEMORY CHARACTERISTICS

Composition for preparing a degradable polyol polyester, process for obtaining a polyol polyester, an elastomer, foams, paints and adhesives, and a degradable polyol polyester foam

Biodegradable phase separated segmented multi block co-polymers

Polymeric biomaterials derived from phenolic monomers and their medical uses

The present invention provides new classes of phenol compounds, including those derived 5 from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices 10 and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Thermoplasticized starch component and process for the preparation thereof

High strength plastics from reactive blending of starch and polylactic acids

BIODEGRADABLE HYDROPHILIC POLYURETHANE FOAMS AND METHOD

EXPANDABLE POLYMERIC ENDOPROSTHESIS WITH SHAPE MEMORY

The invention relates to an endoprosthesis designed for delivery into a body lumen, the endoprosthesis being formed of a polymer comprising one or more of (a) a polycyclooctene, (b) a polymer blend comprising a crystalline polymer and an amorphous polymer, and (c) a reaction product of polyol, diisocyanate, and a dihydroxy-terminated polyhedral oligosilsesquioxane, wherein the endoprosthesis is in a collapsed state so that the endoprosthesis can be delivered into the body lumen, and wherein the endoprosthesis is capable of reverting from the collapsed state to an expanded state when warmed after delivery to the body lumen.

IMPROVED BIODEGRADABLE POLYMERS

Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities.

CROSS-LINKED RADIOPAQUE BIORESORBABLE POLYMERS AND DEVICES MADE THEREFROM

The present application provides polymer materials having the desired properties for implantation into a human or animal body, in particular, biocompatibility, biodegradability, radiopacity and mechanical properties. Methods of making such polymer materials, compositions or devices comprising such polymer materials, and uses of such polymer materials, compositions and devices are also disclosed.

COPOLYMER, PRODUCTION METHOD THEREOF, AND RESIN COMPOSITION

Disclosed are: a water-insoluble copolymer having a constituent unit (X) derived from a hydroxycarboxylic acid and a constituent unit (Y) derived from an amino group-containing polyvalent carboxylic acid, wherein the molar ratio between the constituent units, namely (X)/(Y) satisfies 2/1 = (X)/(Y) < 8/1 and the amide bond ratio of the constituent unit (Y) represented by formula (1) is within the ranges of formulae (2-1)-(2-3); a method for producing this copolymer; and a resin composition which contains this copolymer. Amide bond ratio (%) = A/Asp × 100 (1) (A = number of moles of amide bonds in constituent unit (Y), Asp = number of moles of constituent unit (Y)) (If 2/1 = (X)/(Y) < 4/1) Amide bond ratio (%) = 25 (2-1) (If 4/1 = (X)/(Y) = 6.5/1) Amide bond ratio (%) = 30 (2-2) (If 6.5/1 < (X)/(Y) < 8/1) Amide bond ratio (%) = 50 (2-3) ...

BLENDS WITH SHAPE MEMORY CHARACTERISTICS

The invention relates to a polymer blend with shape memory characteristics, comprising two different block copolymers, each of which contains a rigid segment and a flexible segment. The two different block copolymers contain an identical flexible segment and only differ in relation to the rigid segment.

BIOABSORBABLE ADHESIVE COMPOUNDS AND COMPOSITIONS

Bioabsorbable compounds which include a polyalkylene oxide backbone with two or more isocyanate substituents are useful as one component adhesives. Absorbable compositions useful as a two component adhesive contain a) a polyethylene oxide having two or more amine substituents with b) a bioabsorbable diisocyanate compound, or alternatively contain a) a polyethylene oxide having two or more isocyanate substituents with b) a bioabsorbable diamine compound, or, alternatively contain a) a bioabsorbable diisocyanate compound and b) a bioabsorbable diamine compound.

POLYURETHANES FOR OSTEOIMPLANTS

... ²²²biological-based polyurethanes and methods of making the same. The ²polyurethanes are formed by reacting a biodegradable polyisocyanate (such as ²lysine diisocyanate) with an optionally hydroxylated biomolecule to form ²polyurethane. The polymers formed may be combined with ceramic and/or bone ²particles to form a composite, which may be used as an osteoimplant.² ...

BIODEGRADABLE SUPERSPREADING ORGANOMODIFIED TRISILOXANE

The invention relates to polyether-modified siloxanes that are super-spreading and at the same time easily biodegradable.

BIODEGRADABLE POLYMER - BIOACTIVE MOIETY CONJUGATES

This specification relates to a biodegradable polymer comprising a plurality of releasable bioactive moieties, the releasable bioactive moieties being pendant from and covalently bonded to the biodegradable polymer backbone, wherein the biodegradable polymer backbone is formed from monomeric units that are each coupled via a biodegradable moiety, and wherein the bioactive moieties are capable of being released at a rate equal to or faster than the rate of biodegradation of the polymer backbone.

OLIGO-ETHYLENE GLYCOL-BASED POLYMER COMPOSITIONS AND METHODS OF USE

The invention provides biodegradable PEAs, PEURs and PEUs that are synthesized by solution polycondensation to include a-amino acids and oligo-ethylene ether segments in the polymer backbone. The polymers can be obtained by substituting oligo- ethylene glycol (OEG) for aliphatic di-acid and diols during their fabrication. Also provided are compositions in which bioactive agents are dispersed in the polymers. The compositions biodegrade by enzymatic action to release incorporated bioactive agents and oligo-ethylene glycol segments, which are fully biodegradable at a molecular weight less than 400 Da,. Due to their comparatively rapid surface enzymatic hydrolysis, the compositions can be used to deliver bioactive agents in a controlled manner within a relatively rapid delivery time, such as about 18 to 24 hours.

PAPER HAVING A MELT-STABLE LACTIDE POLYMER COATING AND PROCESS FOR MANUFACTURE THEREOF

A lactide polymer coating resulting in a strong, repulpable, high gloss, pap er coating. The lactide polymer comprises a plurality of poly(lactide) polymer chains, residual lactide in concentration of less than about 5% and water in concentration of less than about 2000 parts-per-million. A process for coating paper with the lactide polymer composition is also disclosed.

DEGRADABLE ARTICLES AND METHODS OF USING SUCH ARTICLES AS DEGRADABLE BAIT

A degradable article comprising a polyurethane polymer gel or foam whose polymer structure contains hydrolytically unstable ester linkages and various additives. The article can be constructed so that some of the additives are released from the article at a sustained rate. In a preferred embodiment the additives are sensory stimulants for marine or aquatic organisms and the article is used as bait for those organisms.

BIODEGRADABLE POLYMERS, THE PREPARATION THEREOF, AND THE USETHEREOF FOR PRODUCING BIODEGRADABLE MOLDINGS

Biodegradable polyether esters P1 obtainable by the reaction of a mixture consisting essentially of: (a1) a mixture essentially of 20 to 95 mol% adipic acid or ester-forming derivatives thereof or mixtures thereof, 5 to 80 mol% terephthalic acid or ester-forming derivatives thereof or mixtures thereof, and 0 to 5 mol% of a sulphonate group-containing compounds in which the sum of the individual mol percentages is 100; and (a2) a mixture of dihydroxy compounds consisting essentially of (a21) 15 to 99 mol% of a dihydroxy compound selected from the group consisting of C2-C6 alkane diols and C5-C10 cycloalkane diols; (a22) 85 to 0.2 mol% of an ether function-containing dihydroxy compound as in formula I HO-¢(CH2)n-O!m-H in which n is 2, 3 or 4 and m is a whole number from 2 to 250, or mixtures thereof, in which the molar ratio of (a1) to (a2) is in the range from 0.4:1 to 1.5:1 with the proviso that the polyether esters P1 have a molar weight (Mn) in the range from 5,000 to 80,000 g/mol, a ...

BIODEGRADABLE POLYMERIC COMPOSITIONS COMPRISING STARCH AND A THERMOPLASTIC POLYMER

Polymeric compositions comprising thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphaticaromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphaticaromatic copolyesters, polyester-amides ...

BIODEGRADABLE POLYESTERS

Biodegradable polyesters are based on: (A) 95 to 99.99 mol % of at least one polyester which contains as monomer constituents: (a1) a mixture of (a11) 20 to 95 mol % of at least one aliphatic or cycloaliphatic dicarboxylic acid and (a12) 5 to 80 mol % of at least one aromatic dicarboxylic acid; and (a2) at least one dihydroxy compound; and (B) 0.01 to 5 mol % of a mixture which contains mononuclear and polynuclear isocyanurates.

ЭЛАСТИЧНЫЕ, ДИСПЕРГИРУЕМЫЕ В ВОДЕ ПОЛИУРЕТАНОВЫЕ ПЕНЫ И СОДЕРЖАЩИЕ ИХ ИЗДЕЛИЯ

Предложена мягкая и эластичная, диспергируемая в холодной воде полиуретановая пена, приемлемая для одноразовых изделий личной гигиены, которую получают путем объединения кукурузного сиропа, глицерина, простого полиэфирдиамина, ПЭГ, диизоцианата, воды и катализатора. Рецептура и реакционные условия для получения заявляемой пены разумно выбраны и тщательно контролируются, чтобы получить диспергируемость в воде и желаемые механические свойства. Характеристическая эластичность или процент упругого восстановления пен обычно превышает 75%, и пены легко производятся в виде мягких пен, проявляющих значение относительного сжатия от 20 до 150% от относительного сжатия промышленных полиуретановых пен в косметических прокладках, которые не диспергируются в воде. Пена может быть введена в полотна и складываемые в пачку изделия или складываемые трехмерные изделия.

Biodegradable polymers, their production and their use in producing biodegradable mouldings

Reduction sensitive type copolymer based on polydisulfide and polyphosphate, and preparation method and application thereof

COPOLYMERS BIODEGRADABLE THERMOPLASTIC BLOCKS OBTAINED BY REACTION Of AUMOINS TWO BLOCKS DIFFERENT POLYESTERS WITH AT LEAST ONE COMPOSES DIISOCYANATE

PROCEEDED OF PREPARATION OF THERMOPLASTIC COMPOSITIONS CONTAINING STARCH PLASTICIZES AND COMPOSITIONS THUS OBTAINED.

La présente invention a pour objet un procédé de préparation d'une composition thermoplastique à base d'amidon comprenant les étapes suivantes : (a) sélection d'au moins un amidon granulaire et d'au moins un plastifiant de cet amidon, (b) préparation d'une composition plastifiée par mélange thermomécanique de cet amidon et de ce plastifiant, (c) incorporation éventuelle d'au moins une substance fonctionnelle porteuse de fonctions à hydrogène actif, (d) incorporation d'au moins un agent de liaison porteur d'au moins deux groupements fonctionnels aptes à réagir avec des molécules porteuses de fonctions à hydrogène actif, et éventuellement (e) le chauffage du mélange jusqu'à une température suffisante pour faire réagir l'agent de liaison avec, le plastifiant et avec l'amidon et/ou la substance fonctionnelle, les étapes (d) et (e) pouvant être simultanées, ainsi qu'une composition thermoplastique à base d'amidon susceptible d'être obtenue par ce procédé.

BIODEGRADABLE RESIN CAPABLE OF BEING SAFELY USED TO PRODUCTS LIKE FOOD OR MEDICINE PACKING MATERIAL WHICH ARE SENSITIVE TO HARMFUL MATERIAL FOR HUMAN BODY, AND A MANUFACTURING METHOD THEREOF

PURPOSE: A manufacturing method of a biodegradable resin is provided to provide excellent physical properties without minimizing the use of chain extender which is harmful for human body or environment. CONSTITUTION: A manufacturing method of a biodegradable resin comprises: a step of manufacturing polyester prepolymer by polycondensation of divalent alcohol monomer and divalent carboxylic acid monomer; a step of controlling the moisture content of polyester prepolymer to 200 ppm or less; and a step of connecting prepolymer by reacting the polyester prepolymer with 0.1 weight% of less of polyvalent isocyanate compound. COPYRIGHT KIPO 2012 ...

POLYLACTIC ACID COPOLYMER HAVING SIGNIFICANTLY IMPROVED ELASTICITY, AND PRODUCING METHOD THEREOF

The present invention relates to a polylactic acid copolymer having significantly improved elasticity, and a producing method thereof and, more specifically, to a polylactic acid copolymer having significantly improved elasticity in comparison with polylactic acid homopolymer, and a producing method thereof. The polylactic acid copolymer comprises: a monocyclic compound having (A) lactic acid and (B) two or more hydroxy-terminated poly (aliphatic ether) chains, as a repetitive unit; a polycyclic compound; or a fused cyclic compound. COPYRIGHT KIPO 2016 ...

Resin compositions having biodegradation and hydrolysis properties

material de polímero sintético biodegradável, e, processo para preparação de um material de polímero sintético biodegradável

BIODEGRADABLE PLASTIC MATERIALS

A method for obtaining polyamides having a general formula [-CO-R'1-CONH-R2-NH-] comprises mixing a first compound having a general formula R1(COOH)2 with a further compound having a general formula R2(NCO)2, to bring about a polymerisation reaction, wherein R1 is a radical provided with at least an alcoholic function; a biodegradable polyamide having a general formula [-CO-R'1-CONH-R2-NH-] is obtained from a first compound R1(COOH)2 and from a further compound R2(NCO)2, wherein R1 comprises a radical provided 10 with at least an alcoholic function.

PROCESS FOR PREPARING A HIGH MOLECULAR WEIGHT HETEROAROMATIC POLYESTER OR COPOLYESTER

The invention relates to a continuous process for preparing a high molecular weight heteroaromatic polyester or copolyester, in which a) at least one heteroaromatic dicarboxylic acid or the diester or an acid anhydride thereof, a heteroaromatic dicarboxylic acid having 2-12 carbon atoms and at least one alcohol having 2 to 12 carbon atoms and at least two hydroxyl functionalities are processed by mixing to give a paste or by mixing at elevated temperature to give a homogeneous solution, b) the paste or solution obtained in step a) is converted to an esterification product comprising at least one diester and/or at least one oligoester, and c) the reaction product obtained from stage b) is polycondensed or copolycondensed under reduced pressure compared to standard conditions, the poly- or copolycondensation stage c) being performed in two stages.

IMPLANTABLE MEDICAL DEVICES

An implantable endoprosthesis (1102, 1106) comprising a tubular member having a first transverse direction that on exposure to an elevated temperature can be expanded to a second transverse direction that is at least fifty percent larger than the first transverse direction.

BIODEGRADABLE COMPOSITE, USE THEREOF AND METHOD FOR PRODUCING A BIODEGRADABLE BLOCK COPOLYESTER-URETHANE

The invention relates to a composite system consisting of at least one biodegradable block copolyester urethane, at least one filler consisting of a polysaccharide and/or derivatives thereof in addition to optional additional biocompatible additives. Said composite systems of this type are used for producing moulded bodies, moulded parts or extrudates. The invention also relates to a method for producing a biodegradable block copolyester-urethane by the polyaddition of a polyhydroxyalkanoate diol, a polyester diol of a dicarboxylic acid monoester and a bifunctional isocyanate.

HYDROXY-TERMINATED POLYHYDROXYALKANOATES

Hydroxy-terminated PHA is produced by cultivating a PHA-producing microorganism in the presence of an aliphatic diol or an aliphatic polyol. High molecular weight hydroxy-terminated PHA is obtainable by the disclosed process, and is useful in the production of graft, block and random polymers and copolymers with other monomers, oligomers and polymers containing appropriate functionality and end group compatibility. The hydroxy-terminated PHAs of the invention display improved thermal stability compared with PHAs not modified to contain increased end-group hydroxyl content. In addition, a branched PHA structure is provided by melt processing polyol terminated PHA.

Degradable articles and methods of using such articles as degradable bait

A degradable article comprising a polyurethane polymer gel or foam whose polymer structure contains hydrolytically unstable ester linkages and various additives. The article can be constructed so that some of the additives are released from the article at a sustained rate. In a preferred embodiment the additives are sensory stimulants for marine or aquatic organisms and the article is used as bait for those organisms.

Method for making a biodegradable adhesive for soft living tissue

A method for making an adhesive for use in joining soft living tissue including the steps of preparing a hydroxyl-terminated polyester by reacting a biodegradable monomer with a polyhydroxy polymerization initiator in the presence of an amount up to about 2.0 weight percent of a catalyst, and then preparing a diisocyanate-terminated prepolymer adhesive by reacting about 24 to 92 weight percent of the hydroxy-terminated polyester with about 8 to 76 weight percent excess aromatic diisocyante. The polyester and the diisocyanate are preferably dissolved in an organic solvent prior to the mixture thereof in a ratio of solids to solvent of about 60:40. The polyester is a polymer or copolymer of lactide, glycolide or ε-caprolactone. The initiator is ethylene glycol, diethylene glycol, pentaerythritol or 1,1,1-tris (hydroxymethyl) ethane. The catalyst is stannous octoate, a zinc compound, an aliphatic tertiary amine, dibutyltin diacetate or 1,4-diazabicyclo [2,2,2] octane.

Resilient, water dispersible polyurethane foams and products incorporating same

A soft and resilient, cold-water dispersible polyurethane foam suitable for disposable personal care products is produced by the combination of corn syrup, glycerin, polyether diamine, PEG, a diisocyanate, water and a catalyst. The formulation and reaction conditions for forming the inventive foam are judiciously selected and carefully controlled to achieve water dispersibility and the desired mechanical properties. The characteristic resiliency, or percent rebound for the foams was generally over 75% and the foams are readily produced as soft foams, exhibiting a relative compression value of from 20% to 150% of that of a commercial polyurethane foam cosmetic pad which is not water dispersible. The foam may be incorporated into webs or stackable products or nestable three-dimensional products.

Viscosity-reduced sprayable compositions

The present disclosure provides sprayable compositions having reduced viscosity which may be used as adhesives or tissue sealants.

Process For Preparing A High Molecular Weight Heteroaromatic Polyester Or Coplyester

A process for preparing a high molecular weight heteraromatic polyester or copolyester is disclosed. A process for preparing a high molecular weight heteroaromatic polyester or copolyester includes the steps of: (a) processing comonomers by mixing together to form a homogeneous solution (1) at least one heteroaromatic dicarboxylic acid having 2-12 carbon atoms or a diester or an acid anhydride derived therefrom, or a mixture thereof; (2) at least one alcohol having 2 to 12 carbon atoms and at least two hydroxyl functionalities; and (3) optionally aromatic or aliphatic dicarboxylic acids or diesters or acid anhydrides derived therefrom; (b) converting the paste/solution obtained in step a) into an esterification product containing at least one diester or at least one oligoester formed from the at least one heteroaromatic dicarboxylic acid and the at least one alcohol; and (c) polycondensing/copolycondensing the reaction product obtained from step b) under reduced pressure. 1. A continuous process for preparing a high molecular weight heteroaromatic polyester or copolyester comprising the steps of: at least one heteroaromatic dicarboxylic acid having 2-12 carbon atoms or a diester or an acid anhydride derived therefrom, or a mixture thereof;', 'at least one alcohol having 2 to 12 carbon atoms and at least two hydroxyl functionalities; and', 'optionally further aromatic or aliphatic dicarboxylic acids or diesters or acid anhydrides derived therefrom;, 'a) processing comonomers by mixing together to form a paste or by mixing under elevated temperature to form a homogeneous solutionb) converting the paste/solution obtained in step a) into an esterification product, the esterification product containing at least one diester or at least one oligoester formed from the at least one heteroaromatic dicarboxylic acid and the at least one alcohol; andc) polycondensing/copolycondensing the reaction product obtained from step b) under reduced pressure compared with standard ...

Enteric elastomers

Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

BIODEGRADABLE COMPOSITIONS HAVING PRESSURE SENSITIVE ADHESIVE PROPERTIES

Aliphatic polyester carbonate and process for producing the same

Polyester injection-molded articles

Injection-molded articles consisting of an aliphatic polyester having a melt viscosity of 6 x 10²-2 x 104 poises at a temperature of 190°C at a shear rate of 1000 sec-1 and a melting point of 70-190°C . The present invention provides injection-molded articles excellent in heat stability and mechanical strength as well as having biodegradability which can be used for industrial parts, automotive members, food and beverage containers, gardening pots and the like.

Biodegradable polymeric compositions comprising starch and a thermoplastic polymer

Polymeric compositions comprising thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophillic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them, B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio R between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyester-amides ...

COMPOSTABLE ADHESIVE

The invention pertains to a compostable adhesive, a process for producing it and its use for gluing together workpieces.

BIODEGRADABLE POLYMERS, PROCESS FOR THEIR PRODUCTION AND THEIR USE IN PRODUCING BIODEGRADABLE MOULDINGS

ORIENTED BLOW MOLDINGS CONSISTING OF ALIPHATIC POLYESTER COMPOSITION

PURPOSE: To obtain oriented blow moldings rapidly biodegradable in compost or soil, excellent in thermal stability and mechanical strength, thus useful as industrial products or any container for detergents, cosmetics and beverages, etc. CONSTITUTION: These oriented blow moldings consist of a composition comprising (A) a linear aliphatic polyester copolymer ≥50000 in number-average molecular weight prepared by binding a diisocyanate to a polyester-diol produced by polycondensation between an acid component composed of 70-90mol% of succinic acid and 10-30mol% of adipic acid and a glycol at the molar ratio of 1:(1-1.1) and (B) an aliphatic polyester prepared by polycondensation between succinic acid and 1,4-butanediol at the molar ratio of 1:(1-1.1), or a composition comprising the component A and (C) or (D) a third component-contg. aliphatic polyester having long chain branched structure. Being predominant in aliphatic polyester copolymer, these oriented blow moldings present relatively ...

ПОЛИУРЕТАНОВАЯ ДИСПЕРСИЯ НА ОСНОВЕ НАТУРАЛЬНОГО МАСЛА

... 1. Полиуретановая дисперсия на основе натурального масла, изготовленная путем:а) формирования диспергируемого в воде полиуретанового преполимера с концевой группой -NCO, в основном состоящего из продукта реакции:i) компонента полиола, преимущественно состоящего из смеси рицинолеата обычного эфира и гидрофобных/гидрофильных олигомерных диолов, который получают без использования системы алкоголиза/этерификации для получения полиола и полиолов, содержащих подходящие карбоксильные группы, как представлено в данном описании; иii) стехиометрического избытка компонента ароматического полиизоцианата, как представлено в данном описании;b) нейтрализации преполимера с помощью подходящих нейтрализующих агентов, как представлено в данном описании;c) диспергирования преполимера в не содержащей растворитель воде по методу, представленному в данном описании; иd) проведения реакции преполимера с подходящим удлинителем цепей, как представлено в данном описании;при которой указанный преполимер, который формируют ...

СПОСОБ ПОЛУЧЕНИЯ ВЫСОКОМОЛЕКУЛЯРНОГО ГЕТЕРОАРОМАТИЧЕСКОГО СЛОЖНОГО ПОЛИЭФИРА ИЛИ СЛОЖНОГО СОПОЛИЭФИРА

... 1. Непрерывный способ получения высокомолекулярного гетероароматического сложного полиэфира или сложного сополиэфира, при которомa) по меньшей мере одну гетероароматическую дикарбоновую кислоту или ее сложный диэфир, или кислотный ангидрид, причем гетероароматическая дикарбоновая кислота содержит 2-12 атомов углерода, и по меньшей мере один спирт, содержащий 2-12 атомов углерода и по меньшей мере две гидроксильные функциональные группы, а также необязательно дополнительные ароматические и/или алифатические дикарбоновые кислоты, или сложные диэфиры, или кислотные ангидриды, полученные из них, и, в случае необходимости, дополнительные сомономеры обрабатывают путем смешивания с образованием пасты или путем смешивания при повышенной температуре с образованием гомогенного раствора,b) пасту/раствор, полученные на этапе a), превращают в продукт эстерификации, содержащий по меньшей мере один сложный диэфир и/или по меньшей мере один олигомерный сложный эфир, образованный по меньшей мере из одной ...

THERMOPLASTIFIZIERTE STÄRKE UND VERFAHREN ZUR HERSTELLUNG

ABBAUBARE, AUF POLYDIOXANON BASIERENDE MATERIALIEN

Polymere mit antimikrobiellen Funktionalitäten

Polymer, aufweisend:eine lonen-Wiederholungseinheit, aufweisend ein Kation, das entlang eines abbaubaren Gerüsts verteilt ist, wobei das abbaubare Gerüst eine Terephthalamidstruktur aufweist, wobei die lonen-Wiederholungseinheit antimikrobielle Funktionalität aufweist, wobei die lonen-Wiederholungseinheit eine Struktur aufweist, die durch Formel 1 gekennzeichnet ist:wobei X das Kation ist, wobei R die hydrophobe funktionelle Gruppe ist, wobei n eine ganze Zahl größer als oder gleich zwei und kleiner als oder gleich eintausend ist undwobei Y eine funktionelle Gruppe ausgewählt aus einer Gruppe bestehend aus einer Estergruppe und einer Carbonylgruppe ist.

METHOD OF PREPARING A BIODEGRADABLE FOAM OF CROSS-LINKED POLYURETHANE

... 1517826 Biodegradable polyurethane foams W R GRACE & CO 16 July 1976 [18 July 1975] 29756/76 Heading C3R Biodegradable, cross - linked polyurethane foams are prepared by reacting with water, under foam-forming and cross-linking conditions, an isocyanate-terminated polyurethane prepolymer which is derived from a polyol reactant comprising a hydroxyester polyol, the amount of water being from 6À5 to 390 moles per mole of isocyanate groups of the prepolymer. For the polyurethane to be cross-linked, suitably either the prepolymer has a functionality greater than two or an isocyanate-reactive cross-linking agent is brought into reaction with the prepolymer. Preferred hydroxyester polyols are esterification products of a hydroxy acid and a polyhydric alcohol. In examples, such polyols are derived from lactic acid and trimethylol-propane, glycolic acid and trimethylolpropane and lactic acid, polyethylene glycol and trimethylolpropane. The polyol component also preferably comprises a polyoxyethylene ...

Polymer compositions

BIOMEDICAL PU AMIDE, ITS PRODUCTION AND USE

BIOLOGICALLY DEGRADABLE ONES POLYMER COMPOSITIONS, THE STRENGTH AND A THERMOPLASTIC POLYMER CONTAINING

BIOLOGICALLY DEGRADABLE ONES OF POLYMERS, PROCEDURES FOR THEIR PRODUCTION AS WELL AS THEIR USE FOR THE PRODUCTION OF BIODEGRADABLE MOLDED ARTICLES

THERMOPLASTIFIZIERTE STRENGTH AND PROCEDURE FOR THE PRODUCTION

BIOLOGICALLY DEGRADABLE ONES POLYMER COMPOSITIONS, THE STRENGTH AND A THERMOPLASTIC POLYMER CONTAINING

BIODEGRADABLES COMPOUND SYSTEM AND ITS USE

MEDICAL ADHESIVES FOR THE SURGERY

POLYESTER COMPOSITION, METHODS FOR THE PRODUCTION OF THESE COMPOSITIONS AND FROM IT MANUFACTURED ARTICLES

POLYHYDROXYALKANOATE WITH HYDROXYL FINAL'S GROUPS

MIXTURES OF AMORPHOUS ONES AND SEMIKRISTALLINEN POLYMERS WITH FORMGEDÄCHTNISEIGENSCCHAFTEN

FUSIONSTABLE LACTID POLYMERFILME ONES AND PROCEDURES FOR YOUR PRODUCTION

Biodisintegratable composite foils

The use of an aqueous polyurethane dispersion adhesive is described for producing biodisintegratable composite foils where at least two substrates are adhesive-bonded to one another with use of the polyurethane dispersion adhesive, where at least one of the substrates is a biodisintegrable polymer foil. At least 60% by weight of the polyurethane is composed of diisocyanates, polyesterdiols, and at least one bifunctional carboxylic acid selected from dihydroxycarboxylic acids and diaminocarboxylic acids.

Functional biodegradable polymers

Biodegradable polyesters are made by synthesizing copolymers derived from biodegradable hydroxyacid monomers as well as from hydroxyacid monomers containing a functional group such as an azide group, a halogen group, a thioacetate group, and the like. Preferably, the functionalized biodegradable polyester copolymers are derived from a functionalized hydroxyacid such as a homolog of lactic acid and/or glycolic acid with the copolyester thus containing functional groups on the backbone thereof. These biodegradable polyesters can be utilized wherever biodegradable polyesters are currently used, and also serve as a polymer to which various medical and drug delivery systems can be attached.

Polymeric biomaterials derived from phenolic monomers and their medical uses

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio

The biocompatible, biodegradable materials in the solid and/or liquid form are based on segmented linear polyurethanes and/or segmented crosslinked polyurethanes based on A) one or more biocompatible polyols susceptible to hydrolytic and/or enzymatic degradation having a molecular weight of 100 to 20,000 dalton and a number of active hydroxyl groups per molecule (functionality) of at least two or higher; B) one or more diisocyanates and/or triisocyanates; and C) one or more low molecular weight chain extenders having a molecular weight of 18 to 1000 dalton and the functionality of at least two or higher.

Implantable medical devices

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

Degradable hyperbranched epoxy resin and preparation method thereof

Degradable hyperbranched epoxy resin and a preparation method thereof, wherein the preparation method comprises carrying out a reaction between a cyclotriazine compound and a carboxyl-sourced compound to prepare a carboxyl-terminated or hydroxy-terminated hyperbranched polymer; then reacting with epoxy chloropropane to obtain a degradable hyperbranched epoxy resin of which the molecular weight is about 1,900-22,000 g/mol. After the degradable hyperbranched epoxy resin is cured, a cyclotriazine structure can be completely degraded within 2 h in a phosphoric acid solution at the temperature of 80 ° C., thus realizing the recycle of the epoxy resin. The invention has simple process, and the product is degradable and has self-strengthening and self-toughening functions, and is expected to be used in the fields of strengthening and toughening of epoxy resins, solvent-free coatings etc.

Copolymer, production method thereof, and resin composition

Disclosed are a water-insoluble copolymer having a constitutional unit (X) derived from a hydroxycarboxylic acid and a constitutional unit (Y) derived from an amino group-containing polyvalent carboxylic acid, wherein the molar ratio (X/Y) of constitutional units is 2/1≤(X/Y)<8/1, and the amide bond proportion of the constitutional unit (Y) represented by the following formula (1) is defined by the following formulae (2-1) to (2-3); a production method thereof, and a resin composition containing the copolymer. Amide bond proportion (%)= A/Asp ×100  (1) [A=number of moles of an amide bond in (Y), Asp=number of moles of (Y)] [when 2/1≤( X/Y )<4/1] amide bond proportion (%)≥25  (2-1) [when 4/1≤( X/Y )≤6.5/1] amide bond proportion (%)≥30  (2-2) [when 6.5/1<( X/Y )<8/1] amide bond proportion (%)≥50  (2-3)

AMPHIPHILIC DEGRADABLE POLYMERS FOR IMMOBILIZATION AND SUSTAINED DELIVERY OF BIOMOLECULES

The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. An amphiphilic biodegradable polymer platform is disclosed herein for the stable encapsulation and sustained release of biomolecules, such as S1P. 1. An amphiphilic degradable block copolymer , comprisinghydrophilic blocks;lipophilic blocks; and{'sub': 6', '24, 'lipophilic blocks having pendent alkyl chains of lengths from about Cto about C.'}4. The amphiphilic degradable block copolymer of claim 3 ,{'sub': 1', '2, 'each of Rand Ris a methyl group;'}{'sub': 12', '18, 'R is a linear alkyl chain of a length from about Cto about C;'}i is an integer from about 200 to about 800;each m is an integer from about 10 to about 100; andeach n is an integer from about 100 to about 500.5. The amphiphilic degradable block copolymer of claim 4 , wherein the ratio of i:m:n ranges from about 1˜50:1˜50:1˜50 to about 50˜1:50˜1:50˜1.6. The amphiphilic degradable block copolymer of claim 1 , having a molecular weight from about 10 claim 1 ,000 to about 1 claim 1 ,000 claim 1 ,000.7. The amphiphilic degradable block copolymer of claim 1 , having a polydispersity from about 1.0 to about 2.0.9. The amphiphilic degradable random copolymer of claim 8 , wherein{'sub': 1', '2, 'each of Rand Ris a methyl group; and'}{'sub': 6', '18, 'R is a linear alkyl chain of a length from about Cto about C.'}10. The amphiphilic degradable random copolymer of claim 8 , wherein the ratio of hydrophilic units:lipophilic units:lipophilic units with alkyl chains ranges from about 1˜50:1˜50:1˜50 to about 50˜1:50˜1:50˜1.1112-. (canceled)13. A fibrous scaffold of made from an amphiphilic degradable copolymer of .14. The fibrous scaffold ...

DEGRADABLE POLYETHERS

Embodiments include degradable polyethers comprising ester units from a cyclic ester or carbonate units from carbon dioxide incorporated into a poly(ethylene oxide) backbone or a multifunctional core of a degradable polyether star. Embodiments include methods of forming a degradable polyether comprising contacting an ethylene oxide monomer with a lactide monomer or carbon dioxide in the presence of an alkyl borane and an initiator. Embodiments include methods of forming degradable polyether stars comprising contacting a diepoxide monomer with carbon dioxide and/or a cyclic ester in the presence of an initiator and a first amount of an alkyl borane to form a multifunctional core comprising degradable carbonate linkages and/or degradable ester linkages, and contacting the multifunctional core with an ethylene oxide monomer in the presence of a second amount of an alkyl borane to form arms of a polyether attached to the degradable multifunctional core. 1. A method of forming a degradable polymer , comprising:contacting an ethylene oxide monomer with carbon dioxide or a cyclic ester in the presence of an alkyl borane and an initiator to form poly(ethylene oxide) having degradable carbonate linkages or degradable ester linkages incorporated into a polymer backbone.2. The method according to claim 1 , wherein the degradable polyether is formed under metal-free conditions.4. The method according to claim 1 , comprising the cyclic ester claim 1 , wherein the cyclic ester is selected from the group consisting of lactide claim 1 , trimethylene carbonate claim 1 , glycolide claim 1 , β-butyrolactone claim 1 , δ-valerolactone claim 1 , γ-butyrolactone claim 1 , γ-valerolactone claim 1 , 4-methyldihydro-2(3H)-furanone claim 1 , alpha-methyl-gamma-butyrolactone claim 1 , ε-caprolactone claim 1 , 1 claim 1 ,3-dioxolan-2-one claim 1 , propylene carbonate claim 1 , 4-methyl-1 claim 1 ,3-dioxan-2-one claim 1 , 1 claim 1 ,3-doxepan-2-one claim 1 , and 5-Calkoxy-1 claim 1 ,3-dioxan-2- ...

METHODS AND COMPOSITIONS FOR BIORENEWABLE POLYESTERS DERIVED FROM CAMPHORIC ACID

In one aspect, the disclosure relates to biorenewable polyesters and polyester copolymers derived from camphoric acid, methods of making same, and articles comprising same. The disclosed biorenewable polyesters can have a Mn of from about 5,000 Da to about 500,000 Da. Also disclosed herein is the preparation of various monomers useful in the reactions disclosed herein, e.g., cis-1,4-anhydroerythritol and bis(2-hydroxyethyl) camphorate. In various aspects, the disclosed biorenewable polyesters and polyester copolymers can be used to the production of various articles utilizing a conventional polyester or polyester copolymer, that is, to replace, in part or in whole, a conventional nonbiorenewable polyester or polyester copolymer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. 145-. (canceled)47. The polyester polymer of claim 46 , wherein Ris hydrogen.51. The polyester polymer of claim 46 , wherein number average molecular weight (M) is from about 7 claim 46 ,300 to about 20 claim 46 ,200 Da.52. The polyester polymer of claim 46 , wherein the dispersity is from about 2.7 to about 4.4.53. The polyester polymer of claim 46 , wherein the glass transition temperature (T) is from about −16° C. to about 125° C.54. The polyester polymer of claim 46 , wherein the temperature at which 5% mass loss under nitrogen is observed according to thermogravimetric analysis (T5) is from about 322° C. to about 368° C.55. The polyester polymer of claim 46 , wherein the polymer is non-crystalline.57. The polyester copolymer of claim 56 , wherein Ris hydrogen.62. The polyester copolymer of claim 56 , wherein the number average molecular weight (M) is from about 13 claim 56 ,300 to about 23 claim 56 ,800 Da.63. The polyester copolymer of claim 56 , wherein the dispersity is from about 2.3 to about 2.9.64. The polyester copolymer of claim 56 , wherein the glass transition temperature (T ...

POLY(GLYCEROL SEBACATE)-INTERLEUKIN INHIBITOR COPOLYMERS AND METHODS OF MAKING AND USE

A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound. 1. A method of preparing a polymeric material , comprising the steps of:combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel, the alcohol-pharmaceutical conjugate comprising a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond;adding an acid monomer to the vessel; andheating and removing water from the vessel to produce the polymeric material;wherein the polymeric material comprises a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.2. The method of further comprising:combining polyol and aqueous liquid;adding the pharmaceutical compound to the polyol and aqueous liquid;heating and removing water to produce the alcohol-pharmaceutical conjugate.3. The method of claim 1 , wherein the heating and removing water from the vessel comprises refluxing the alcohol-pharmaceutical conjugate claim 1 , the polyol claim 1 , the aqueous liquid claim 1 , and the acid monomer.4. The method of claim 1 , wherein the heating and removing water from the vessel further comprises reducing a pressure in the vessel to the range of 5 Torr to 20 Torr.5. The method of claim 1 , wherein the polyol comprises glycerol.6. The method of claim 1 , wherein the aqueous liquid is water.7. The method of claim 1 , wherein the acid monomer comprises a diacid.8. The method of claim 7 , wherein the diacid comprises a compound of the formula [HOOC(CH)COOH] claim 7 , ...

Class of Anti-Adhesion Hydrogels With Healing Aspects

Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.

HYPERBRANCHED POLYMERS AND POLYPLEXES AND DNA OR RNA DELIVERY SYSTEMS INCLUDING THE SAME

A hyperbranched polymer includes a hyperbranched, hydrophobic molecular core, respective low molecular weight polyethyleneimine chains attached to at least three branches of the hyperbranched, hydrophobic molecular core, and respective polyethylene glycol chains attached to at least two other branches of the hyperbranched, hydrophobic molecular core. Examples of the hyperbranched polymer may be used to form hyperbranched polyplexes, and may be included in DNA or RNA delivery systems. 1. A hyperbranched polymer , comprising:a hyperbranched, hydrophobic molecular core;respective low molecular weight polyethyleneimine chains attached to two or more branches of the hyperbranched, hydrophobic molecular core; andrespective polyethylene glycol chains attached to two or more other branches of the hyperbranched, hydrophobic molecular core.2. The hyperbranched polymer as defined in wherein the hyperbranched claim 1 , hydrophobic molecular core is a hyperbranched polyester including at least 4 terminal hydroxyl groups.3. The hyperbranched polymer as defined in wherein the low molecular weight polyethyleneimine chains each have a molecular weight ranging from about 400 g/mol to about 5 claim 1 ,000 g/mol.4. A linear polymer claim 1 , comprising:a polyethylene glycol chain;a polyester chain attached to an end of the polyethylene glycol chain; andrespective low molecular weight polyethyleneimine chains attached as side chains to the polyester chain.5. The linear polymer as defined in wherein the polyester chain is selected from the group consisting of polylactide claim 4 , polycaprolactone claim 4 , polycarbonate claim 4 , poly(phosphoesters) claim 4 , polyanhydrides claim 4 , and polyglycolic acid.6. The linear polymer as defined in wherein the low molecular weight polyethyleneimine chains each have a molecular weight ranging from about 400 g/mol to about 5 claim 4 ,000 g/mol.7. A hyperbranched polyplex claim 4 , comprising:a hydrophilic inner section formed of a first plurality ...

Biorenewable, water-degradable polymers and co-polymers

Various embodiments relate to biorenewable and water-degradable co-polymers and methods of producing co-polymers that include a plurality of first monomeric units and a plurality of second monomeric units joined by a plurality of hydrolytically-sensitive ester linkages. Each of the plurality of first monomeric units may be derived from a first monomer. The first monomer may be the product of a reaction between itaconic acid and a first amino acid. Each of the plurality of second monomeric units may be derived from a second monomer. The second monomer may be the product of a reaction between itaconic acid and a second amino acid. The co-polymers may be a product of the reaction of the first monomer and the second monomer in the presence of a diol. The co-polymers may have a glass transition temperature of about 50° C. or greater.

Poly(glycerol sebacate)-interleukin inhibitor copolymers and methods of making and use

A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.

Enteric elastomers

Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

DOPANT-FREE CONDUCTIVE BIOELASTOMERS

The present invention provides dopant-free conductive elastomeric polyurethanes that have broad biomedical application, including smart drug delivery, electronics and biomedicine. In various embodiments, a dopant-free conductive, elastomeric polyurethane is designed by covalently conjugating biodegradable segment, conductive segment and dopant molecule into one polymer chain. The dopant-free conductive polyurethanes according to various embodiments of the invention exhibit attractive mechanical properties, including bending, knotting, stretching and recoiling. The biodegradable, conductive elastomer also exhibit good electroactivity and electrical stability without extra dopant involvement. 1. A dopant free conductive polyurethane elastomer (DCPU) comprising polymeric diol (PD) , diisocyanate (DI) , bishydroxy acid (BHA) , and aniline oligomer (AO) having a formula of{'br': None, 'sub': x', 'n', 'z', 'm', 'y, '—(O-PD-O)—(CO—NH-DI—NH—CO)—(NH-AO-NH)—(CO—NH-DI—NH—CO)—(O—BHA-O)—'}wherein the ratio between x:y:(n+m):z is in the range of 0.95:0.5:2:1 and 0.5:0.5:2:1.2. The elastomer of claim 1 , wherein said polymeric diol is selected from polycaprolactone (PCL) claim 1 , poly (trimethylene carbonate) (PTMC) claim 1 , poly (hexamethylene carbonate) claim 1 , poly (lactide-co-caprolactone) (PLC) claim 1 , poly (6-valerolactone-co-caprolactone) (PVCL) claim 1 , and poly ethylene glycol (PEG) containing triblock copolymer diols of PCL-PEG-PCL claim 1 , PTMC-PEG-PTMC claim 1 , PVCL-PEG-PVCL claim 1 , or PLC-PEG-PCL.3. The elastomer of claim 1 , wherein said aniline oligomers is selected from the group consisting of aniline trimer claim 1 , aniline tetramer claim 1 , aniline pentamer claim 1 , aniline hexamer claim 1 , aniline heptamer claim 1 , and aniline octamer.4. The elastomer of claim 1 , wherein said diisocyanate is selected from the group consisting of butane diisocyanate (BDI) claim 1 , hexamethylene diisocyanate (HDI) claim 1 , and L-lysine diisocyanate.5. The ...

USE OF POLY(ALKYLENE TEREPHTHALATES) AND METHODS FOR THEIR PREPARATION

The present invention relates to poly(alkylene terephthalate) polyesters having long poly-methylene segments and their use in a wide variety of applications. Particularly, said PAT polyesters are used in biotechnological or biomedical applications, wherein the extent of cell adhesion, cell growth or cell interaction, in particular endothelial cells, depends on the odd or even number of carbon atoms in the aliphatic segments. Also provided are methods for the preparation of poly(alkylene terephthalates) (PAT) having long poly-methylene segments, wherein the bifunctional monomers, in particular terephthalic acid (or a derivative thereof) and an aliphatic diol, are dissolved in a solvent and the polycondensation reaction takes place in solution. 2. The cell growth support product of claim 1 , wherein n=5-12 and p=3 to 100 or more.3. The cell growth support product of wherein n=6 claim 2 , 8 claim 2 , 10 or 12 and wherein said cell population is a macrovascular endothelial cell population claim 2 , a microvascular endothelial cell population claim 2 , or a combination thereof.4. The cell growth support product of wherein n=5 claim 2 , 7 claim 2 , 9 claim 2 , or 11 and wherein said cell population is a macrovascular endothelial cell population.5. The cell growth support product of wherein said cell growth support product and said surface thereof comprises the polyester polymer having the structure (A).6. The cell growth support product of wherein said surface comprising the polyester polymer having the structure (A) is in the form of a coating on said cell growth support product.7. The cell growth support product of wherein said product is an article claim 1 , vessel or bioreactor for cell culture applications claim 1 , such as an array claim 1 , chip or multi-well plate.8. The cell growth support product of wherein said product is an implantable medical device claim 1 , such as a synthetic vein or vascular graft claim 1 , or a tissue engineering scaffold.10. The method ...

Biodegradable Poly(Ester Amide) Elastomers and Uses Therefor

Provided herein are biodegradable poly(ester amide) elastomers, methods of making the elastomers, and methods of using the elastomers, for example for tissue engineering. The elastomers can be used for preparation of tissue prostheses, such as a heart valve leaflet, a heart valve, cartilage, myocardium, blood vessels, smooth muscle, skeletal muscle, or other tissues. Also provided herein are semiquantitative FTIR methods for determining structure of a poly(ester amide) elastomer. 1. A polymer composition comprising a copolymer comprising residues of a poly (C-C)alkylene glycol , an aliphatic C-Cpolyol with at least 3 hydroxyl groups , and 1 ,3-diamino-2-hydroxy-propane.2. The polymer composition of claim 1 , wherein the aliphatic C-Cpolyol with at least 3 hydroxyl groups is glycerol claim 1 , the poly (C-C)alkylene glycol is a polyethylene glycol claim 1 , and/or the dicarboxylic acid is sebacic acid.3. The polymer composition of claim 1 , wherein the poly (C-C)alkylene glycol has a Mof from 200 D (Daltons) to 10 kD (kiloDaltons).4. The polymer composition claim 1 , wherein the molar feed percentage of the poly (C-C)alkylene glycol to the dicarboxylic acid ranges from 10% to 50% claim 1 , or from 15% to 40%.5. The polymer composition of claim 1 , wherein the poly (C-C)alkylene glycol is polyethylene glycol having a Mn of from 400 D to 4 kD claim 1 , the aliphatic C-Cpolyol with at least 3 hydroxyl groups is glycerol claim 1 , the dicarboxylic acid is sebacic acid claim 1 , and the feed percentage of polyethylene glycol to sebacic acid ranges from 1% to 60% claim 1 , and optionally from 15% to 40%.6. The polymer composition of claim 1 , having a Mn of from 3 kD to 10 kD and/or a polydispersity index of less than 2.7. The polymer composition of claim 1 , further comprising an active agent.8. The polymer composition of claim 7 , wherein the active agent is an antioxidant.9. The polymer composition of claim 8 , wherein the active agent is a cerium nanoparticle.10. A ...

CYCLIC CARBONATE MONOMER CONTAINING DOUBLE IODINE, BIODEGRADABLE POLYMER PREPARED THEREBY AND USE

The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media. 2. A method for preparing the cyclic carbonate monomer containing double iodine of claim 1 , wherein the method comprises the following steps: in a low-boiling point solvent claim 1 , reacting dibromoneopentyl glycol with metal iodide to obtain Compound A; then in nitrogen atmosphere and cyclic ether-based solvent claim 1 , reacting Compound A with ethyl chloroformate and triethylamine to obtain the cyclic carbonate monomer containing double iodine.4. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 3 , wherein the amount of iodine in the molecular chain of aforesaid biodegradable polymer containing a functional group of double iodine in the side chain is 5%-65%.5. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 3 , wherein cyclic ester monomer is glycolide claim 3 , caprolactone or lactide; said other carbonate monomer is cyclic carbonate containing double-sulfur claim 3 , 2 claim 3 ,4 claim 3 ,6-trimethoxybenzylidene-pentaerythritol carbonate or trimethylene cyclic carbonate.6. The biodegradable polymer containing a functional group of double iodine in the side chain according to claim 3 , wherein the cyclic carbonate monomer containing double iodine is polymerized in the form of polyethylene glycol claim 3 , ethylene glycol claim 3 , isopropanol or propynol as the ...

NOVOLAC PHENOLIC RESINS, PROCESS OF SYNTHESIS OF SAID PHENOLIC RESINS AND USE THEREOF

The present invention relates to a novolac-type phenolic resin synthesis process in which there is the addition of lignin, to a novolac-type phenolic resin comprising lignin, and to the use of said phenolic resin.

BIODEGRADABLE POLYMERS

Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities. 1. A composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is poly(D ,L-lactic-co-glycolic acid) , wherein the poly(D ,L-lactic-co-glycolic acid) contains less than 1.0 weight percent (wt/wt) of oligomeric acidic fragments of poly(D ,L-lactic-co-glycolic acid).2. The composition of claim 1 , wherein the poly(D claim 1 ,L-lactic-co-glycolic acid) has a ratio of lactic acid monomer to glycolic acid monomer ranging from 82:18 to 88:12.3. The composition of claim 1 , wherein the poly(D claim 1 ,L-lactic-co-glycolic acid) has a weight average molecular weight of about 4 claim 1 ,000 Dalton to about 8 claim 1 ,000 Dalton.4. A method for the preparation of a composition comprising poly(D claim 1 ,L-lactic-co-glycolic acid) substantially free of acidic impurities claim 1 , said method comprising:contacting poly(D,L-lactic-co-glycolic acid) containing acidic impurties with a solid base;forming a salt of the acidic impurity; andseparating the poly(D,L-lactic-co-glycolic acid) from the salt of the acidic impurity.5. A method for the preparation of a composition comprising poly(D claim 1 ,L-lactic-co-glycolic acid) substantially free of acidic impurities claim 1 , said method comprising:dissolving the poly(D,L-lactic-co-glycolic acid) containing acidic impurties in an inert solvent;contacting poly(D,L-lactic-co-glycolic acid) solution with a metal hydride;forming a metal salt of the acidic impurity; andseparating the poly(D,L-lactic-co- ...

Polymeric materials for bio-applications

A composition comprising a biodegradable polymeric material and therapeutic agent associated with the polymeric material that advantageously can provide controlled release of the therapeutic agent, while comprising little to no auxiliary materials. In some embodiments, the composition is formed by the reaction of one or more monomers in the presence of a food grade catalyst. In another embodiment, the composition comprises a polymeric material capable of undergoing thermal reconfiguration (i.e. a dynamic network). Advantageously, the compositions and materials described herein may comprise a reconfigurable polymeric material (e.g., a thermoset polymeric material) having the strength and integrity of epoxy resins, the biomedical applicability of hydrogels, and/or the moldability of vitrimers.

Implantable medical devices

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.

Biodegradable polyester and use thereof

The present invention relates to a biodegradable polyester and use thereof, including components: A) acid components containing following repeating units: 50 to 58 mol % of terephthalic acid A1; 30 to 40 mol % of sebacic acid A2; and 2 to 20 mol % of an aliphatic dibasic acid A3 with a carbon chain length of 6 or less; B) butanediol. In the present invention, in the case of a high content of the terephthalic acid, the biodegradable polyester prepared by introducing an aliphatic dibasic acid unit having a carbon chain length of 6 or less can satisfy the degradation performance and rigidity and improve the tenacity of the material simultaneously.

MULTI-ARMED POLYMERS COMPRISING FREE-RADICAL-POLYMERIZABLE MONOMERS AND COMPOSITIONS, SYSTEMS AND METHODS PERTAINING TO THE SAME

In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core, a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group, wherein the polymer segments comprise one or more free-radical-polymerizable monomers. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound. 1. A multi-arm polymer comprising a core , a plurality of polymer segments having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group , wherein the polymer segments comprise one or more free-radical-polymerizable monomers.2. The multi-arm polymer of claim 1 , wherein the polymer segments comprise one or more hydrophilic aprotic monomers.3. The multi-arm polymer of claim 1 , wherein the polymer segments comprise one or more monomers selected from N-vinyl pyrrolidone claim 1 , hydroxyethyl acrylate claim 1 , hydroxyethyl methacrylate claim 1 , PEG methyl ether acrylate and PEG methyl ether methacrylate.4. The multi-arm polymer of claim 1 , wherein the core is a polyol residue core.5. The multi-arm polymer of claim 1 , wherein the reactive group is an electrophile.6. The multi-arm polymer of claim 1 , wherein the reactive group is selected from N-hydroxysuccinimide esters claim 1 , imidazole esters claim 1 , imidazole carboxylates and benzotriazole esters.7. The multi-arm polymer of claim 1 , wherein the reactive group is a nucleophile.8. The multi-arm polymer of claim 1 , wherein the reactive group is an amine group.9. The multi-arm polymer of claim 1 , ...

THE SYNTHESIS OF MULTIARM POLY[(R)-3-HYDROXYBUTYRATE] AND ITS DERIVATIVES

Provided herein is a polymer having formula I: 131-. (canceled)331. The polymer according to claim , wherein the polymer has a number average molecular weight of from 1 ,000 to 10 ,000 Daltons.341. The polymer according to claim , wherein Rrepresents a straight-chain or branched Calkyl and n represents 0 to 5.364. The polymer according to claim , wherein:{'sup': '1', '(a) when Rrepresents hexyl, the number average molecular weight of the polymer is from 1,000 to 7,000 Daltons;'}{'sup': '1', '(b) when Rrepresents the fragment of formula Ia, the number average molecular weight of the polymer is from 750 to 60,000 Daltons;'}{'sup': '1', '(c) when Rrepresents the fragment of formula Ib, the number average molecular weight of the polymer is from 750 to 60,000 Daltons; and'}{'sup': '1', '(d) when Rrepresents the fragment of formula Ic, the number average molecular weight of the polymer is from 750 to 60,000 Daltons.'}386. The process according to claim , wherein Rrepresents a straight-chain or branched Calkyl , or a straight-chain or branched Calkyl substituted with from 0 to 5 hydroxyl groups.408. The process according to claim , wherein:{'sup': '1', '(a) when Rrepresents hexanol, the number average molecular weight of the compound of formula I is from 1,000 to 7,000 Daltons;'}{'sup': '1', '(b) when ROH represents the compound of formula Ia, the number average molecular weight of the compound of formula I is from 750 to 60,000 Daltons;'}{'sup': '1', '(c) when ROH represents the compound of formula Ib, the number average molecular weight of the compound of formula I is from 750 to 60,000 Daltons; and'}{'sup': '1', '(d) when ROH represents the compound of formula Ic, the number average molecular weight of the compound of formula I is from 750 to 60,000 Daltons.'} This patent application is a divisional of U.S. patent application Ser. No. 15/551,591, filed Aug. 16, 2017, which is a U.S. National Phase Application under 35 U.S.C. § 371 of International Application No. PCT/ ...

ABSORBENT POLYMERS, AND METHODS OF PRODUCING THEREOF AND USES THEREOF

Provided herein are absorbent polymers produced from beta-propiolactone, and methods of producing such polymers. These absorbent polymer may be cross-linked. The beta-propiolactone may be derived from ethylene oxide and carbon monoxide. The absorbent polymer may be bio-based and/or bio-degradable. The absorbent polymers may be used for diapers, adult incontinence products, and feminine hygiene products, as well as for agricultural applications. 1. A method of producing a cross-linked polymer , comprising combining beta-propiolactone and a cross-linker in the presence of a metal cation to produce the cross-linked polymer ,wherein the cross-linked polymer comprises a partially neutralized polyacrylic acid backbone and a plurality of polypropiolactone side chains, and cross-linking moieties.2. The method of claim 1 , wherein the metal cation is provided as a metal salt.3. The method of claim 2 , wherein the metal is an alkali metal or an alkali-earth metal.4. The method of claim 2 , wherein the metal is sodium or potassium.5. The method of claim 2 , wherein the metal cation is provided as metal acrylate.6. The method of claim 5 , wherein the metal acrylate is sodium acrylate or potassium acrylate.7. A method of producing a cross-linked polymer claim 5 , comprising combining beta-propiolactone and a cross-linker to produce the cross-linked polymer claim 5 ,wherein the cross-linked polymer comprises a partially neutralized polyacrylic acid backbone and a plurality of polypropiolactone side chains, and cross-linking moieties.8. The method of claim 1 , wherein the polypropiolactone side chains independently have a structure of formula —(CHCH(C═O)—O)M claim 1 , wherein:n is an integer from 1 to 10 inclusive; and{'sup': +', '+, 'Mis an alkali metal, a cross-linking moiety, or H.'}9. The method of claim 1 , wherein the cross-linker comprises:an acrylamide compound,a metal acrylate compound,an organic carbonate compound,a diglycidyl compound, ora vinyl-organic compound ...

BIODEGRADABLE POLYMERS

Provided herein is a composition comprising a poly(alpha-hydroxycarboxylic acid) substantially free of acidic impurities wherein the poly(alpha-hydroxycarboxylic acid) is selected from poly(D,L-lactic-co-glycolic acid), poly(L-lactic acid), poly(D-lactic acid) and poly(D,L-lactic acid). Also provided is a device comprising: a substrate, and a coating wherein the coating comprises poly(D,L-lactic-co-glycolic acid) substantially free of acidic impurities. 1. A method for the preparation of a composition comprising poly(D ,L-lactic-co-glycolic acid) substantially free of acidic impurities , said method comprising:contacting poly(D,L-lactic-co-glycolic acid) containing acidic impurties with a solid base;forming a salt of the acidic impurity; andseparating the poly(D,L-lactic-co-glycolic acid) from the salt of the acidic impurity.2. A method for the preparation of a composition comprising poly(D ,L-lactic-co-glycolic acid) substantially free of acidic impurities , said method comprising:dissolving the poly(D,L-lactic-co-glycolic acid) containing acidic impurties in an inert solvent;contacting poly(D,L-lactic-co-glycolic acid) solution with a metal hydride;forming a metal salt of the acidic impurity; andseparating the poly(D,L-lactic-co-glycolic acid) from the metal salt of the acidic impurity.3. A method for the preparation of a composition comprising poly(D ,L-lactic-co-glycolic acid) substantially free of acidic impurities , said method comprising:forming the poly(D,L-lactic-co-glycolic acid) containing acidic impurties into a thin film;contacting said poly(D,L-lactic-co-glycolic acid) thin film with a layer of solid base;diffusing the acidic impurties from said poly(D,L-lactic-co-glycolic acid) thin film; andseparating the poly(D,L-lactic-co-glycolic acid) thin film from the layer of solid base.4. A method for the preparation of a composition comprising poly(D ,L-lactic-co-glycolic acid) substantially free of acidic impurities , said method comprising subjecting the ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179.-. (canceled)80. An article , comprising:a containing ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179.-. (canceled)80. A method for delivering a residence ...

DEGRADABLE BEARING PALLET AND PREPARATION METHOD THEREOF

A degradable bearing pallet and a preparation method thereof. The pallet has an upper cover, a packing middle layer and a lower cover; a plurality of pallet support legs are disposed at the bottom of the lower cover; the lower cover is integrally molded with the plurality of pallet support legs; and the packing middle layer is filled in the lower cover and in the plurality of pallet support legs; the upper cover covers the packing middle layer and the lower cover. The middle part of the bottom of each of the pallet support legs is formed with a sunken groove; the pallet support legs in each of the rows are mutually connected through a connecting board; and each of the connecting boards is clamped in a corresponding one of the sunken grooves. 112243342341234. A degradable bearing pallet , comprising an upper cover () , a packing middle layer () and a lower cover () , characterized in that a plurality of pallet support legs () are disposed at the bottom of the lower cover (); the lower cover () is integrally molded with the plurality of pallet support legs (); the packing middle layer () is filled in the lower cover () and in the plurality of pallet support legs (); the upper cover () covers the packing middle layer () and the lower cover (); and the section of each of the pallet support legs () is shaped as a reverse trapezoid.24344145541. The degradable bearing pallet according to claim 1 , characterized in that the lower cover () is separately provided with at least three rows of pallet support legs (); at least three pallet support legs are arrayed in each of the rows; the middle part of the bottom of each of the pallet support legs () is formed with a sunken groove (); the pallet support legs () in each of the rows are mutually connected through a connecting board (); and each of the connecting boards () is clamped in a corresponding one of the sunken grooves ().3433. The degradable bearing pallet according to claim 2 , characterized in that the section of each ...

Pegylated carfilzomib compounds

The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R 1 , R 2 , linker, PEG, n and o are as defined herein.

Biomedical Foams

The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers. 1. A method of preparing a foam suitable for packing antrums or other cavities of the human or animal body , said method comprising the steps of: [{'br': None, 'A-R-A′\u2003\u2003(III),'}, {'br': None, 'O═C═N—R′—N═C═O \u2003\u2003(IV),'}, 'with one or more diisocyanates of a formula (IV), [{'br': None, 'B—R″—B′\u2003\u2003(V),'}, 'wherein A, A′, B and B′ are independently selected from hydroxyl, carboxyl or amine,', 'wherein R is selected from one or more aliphatic polyesters, polyetheresters, polyethers, polyanhydrides and/or polycarbonates, and at least one R comprises an amorphous segment and a crystalline segment, wherein the amorphous segment comprises a hydrophilic segment comprising polyethyleneglycol, polypropyleneglycol or polybutyleneglycol, and', {'sub': 2', '8', '1', '10', '1', '10', '2', '8, 'wherein R′ and R″ are independently C-Calkylene, optionally substituted with C-Calkyl or C-Calkyl groups substituted with protected S, N, P or O moieties and/or comprising S, N, P or O in the C-Calkylene;'}], 'and one or more chain extenders of a formula (V)], 'producing a phase-separated polymer in a solvent by reacting one or more pre-polymers according to a formula (III)cooling the phase-separated polymer in the solvent to crystallize the polymer and crystallize the ...

Method for preparing modified biodegradable polylmer, modified biodegradable polymer prepared therefrom, and biodegradable stent using the same

Disclosed are a method for preparing a modified biodegradable polymer by using various additives and plasticizers in a biodegradable polymer which is non-toxic to human bodies, a biodegradable polymer prepared therefrom, and a biodegradable stent prepared by using the biodegradable polymer. Specifically, it is possible to reduce a decrease in molecular weight resulting from a thermal degradation occurring during the solid-phase molding processing of a biodegradable polymer by coating a solution in which various additives are dissolved during the modification of the biodegradable polymer to convert the hydroxyl end group into a functional group of a carboxylic group or a different kind of hydroxyl group.

ABSORBABLE POLYURETHANES AND METHODS OF USE THEREOF

Disclosed are novel bioabsorbable and biodegradable monomer compounds, bioabsorbable and biodegradable polymers therefrom, and methods of making such monomers and polymers, which are useful in pharmaceutical delivery systems, tissue engineering applications, tissue adhesives products, implantable medical devices, foams and reticulated foams for wound healing and drug delivery, bone hemostats and bone void fillers, adhesion prevention barriers, meshes, filters, stents, medical device coatings, pharmaceutical drug formulations, consumer product and cosmetic and pharmaceutical packaging, apparel, infusion devices, blood collection tubes and devices, other medical tubes, skin care products, and transdermal drug delivery materials. 120-. (canceled)22. The surgical article of claim 21 , wherein the surgical article is a medical device coating which is a stent coating.23. The surgical article of claim 21 , wherein the surgical article is a medical implantable device selected from the group consisting of: stents claim 21 , arterial grafts claim 21 , arterial substitutes claim 21 , anastomosis rings claim 21 , prosthetic devices claim 21 , clips claim 21 , staples claim 21 , sutures claim 21 , ligatures claim 21 , hooks claim 21 , pins claim 21 , couplings claim 21 , vascular implants claim 21 , vascular supports claim 21 , vertebral discs claim 21 , textile structures claim 21 , screws claim 21 , tubes claim 21 , buttons claim 21 , snaps claim 21 , films claim 21 , meshes claim 21 , liver hemostasis articles claim 21 , transdermal drug delivery claim 21 , and controlled drug delivery systems.24. The surgical article of claim 23 , wherein the surgical article is stent.25. The surgical article of claim 23 , wherein the orthopedic article is selected from the group consisting of: pins claim 23 , clamps claim 23 , screws claim 23 , and plates.26. The surgical article of claim 23 , wherein the clip is a vena cava clip or a suture knot clip.27. The surgical article of claim 23 , ...

DEGRADABLE RESIN COMPOSITION, DEGRADABLE CURED PRODUCT AND DOWNHOLE TOOL FOR DRILLING

Disclosed are a degradable resin composition including a cyanate ester (A) and a compound (B) having a hydroxyl group with a hydroxyl group equivalent of less than 240 g/eq., and a degradable cured product and a downhole tool for drilling using the same. 1. A degradable resin composition comprising:a cyanate ester (A) and,a compound (B) having a hydroxyl group with a hydroxyl group equivalent of less than 240 g/eq.2. The degradable resin composition according to claim 1 , wherein the compound (B) comprises a polyol having two or more hydroxyl groups in one molecule.3. The degradable resin composition according to claim 1 , wherein the compound (B) comprises at least one or more compounds selected from a compound having an alcoholic hydroxyl group claim 1 , a compound having a phenolic hydroxyl group claim 1 , and a compound having an alcoholic hydroxyl group and a phenolic hydroxyl group.4. The degradable resin composition according to claim 1 , wherein the compound (B) comprises at least one selected from the group consisting of an aliphatic polyol (b1) claim 1 , an alicyclic polyol (b2) claim 1 , an aromatic polyol (b3) claim 1 , and a trialkanolamine (b4).5. The degradable resin composition according to claim 4 , wherein the aliphatic polyol (b1) comprises at least one selected from the group consisting of ethanediol claim 4 , propanediol claim 4 , propanetriol claim 4 , propanetetraol claim 4 , butanediol claim 4 , butanetriol claim 4 , butanetetraol claim 4 , pentanediol claim 4 , pentanetriol claim 4 , pentanetetraol claim 4 , pentanepentaol claim 4 , hexanediol claim 4 , hexanetriol claim 4 , hexanetetraol claim 4 , hexanepentaol claim 4 , hexanehexaol claim 4 , diglycerol claim 4 , ditrimethylolpropane claim 4 , tritrimethylolpropane claim 4 , dineopentylglycol claim 4 , dipentaerythritol claim 4 , tripentaerythritol claim 4 , polyvinyl alcohol and polyvinyl acetal.6. The degradable resin composition according to claim 4 , wherein the alicyclic polyol (b2) ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179-. (canceled)80. A method for delivering a residence ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179-. (canceled)80. An article , comprising:a gastric residence ...

SHAPE MEMORY POLYMER BASED ON POLY(HYDROXYALKANOATES)

Shape memory polymers and copolymers are based on poly(hydroxyalkanoates) (PHA) and have improved elastomeric properties. The shape memory polymers and copolymers may be used as protective, reinforcement, cladding or embellishment material having mechanical properties enabling substitution to materials based on technical polymers such as plasticized PVC and polyolefins.

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179-. (canceled)80. A gastric residence structure , comprising: ...

DYNAMIC UREA BONDS WITH FAST HYDROLYTIC KINETICS FOR POLYMERS

The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs) with fast hydrolytic kinetics. These urea bonds are aryl-substituted, i.e. aromatic-substituted hindered urea bonds, that demonstrate pH independent hydrolytic kinetics, such that they consistently and rapidly hydrolyze in water from pH 2 to 11. The urea bond dissociation for these materials is generally such that k>h, which is two orders of magnitudes faster than for aliphatic hindered ureas. The present invention also relates to hydrolytically reversible or degradable linear, branched or network polymers incorporating these HUBs and to precursors for incorporation of these HUBs into these polymers. The technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating these HUBs can be used in a wide variety of applications including for example, environmentally compatible packaging materials and biomedical applications, such as drug delivery systems and tissue engineering. In other embodiments, the HUBs can be used in self-healing polymers. 2. A hydrolysable polymer according to wherein R claim 1 , R claim 1 , R claim 1 , are each methyl.3. A hydrolysable polymer according to wherein Ris selected from H claim 2 , methyl claim 2 , and ethyl.4. A hydrolysable polymer according to wherein Ris selected from H and methyl.5. A hydrolysable polymer according to wherein Ris H.6. A hydrolysable polymer according to wherein Aris selected from phenyl claim 1 , naphthyl claim 1 , furyl claim 1 , benzofuryl claim 1 , oxazolyl claim 1 , isoxazolyl claim 1 , oxadiazolyl claim 1 , benzoxazolyl claim 1 , benzoxadiazolyl claim 1 , pyrrolyl claim 1 , pyrazolyl claim 1 , imidazolyl claim 1 , triazolyl claim 1 , tetrazolyl claim 1 , pyridyl claim 1 , pyrimidyl claim ...

Biodegradable Triblock Copolymers and Implantable Medical Devices Made Therefrom

A biodegradable triblock copolymer comprising: an A-B-A′ structure wherein the A and A′ blocks each include polylactide, the B block includes from about 55 to about 100 mole percent of polytrimethylene carbonate and 0 to about 45 mole percent polylactide, and the biodegradable triblock copolymer overall includes from about 15 to about 25 mole percent of the polytrimethylene carbonate and from about 75 to about 85 mole percent of the polylactide. Also provided are compositions and implantable medical devices made therefrom. 1. A biodegradable triblock copolymer comprising:an A-B-A′ structure wherein the A and A′ blocks each include polylactide, the B block includes from about 55 to about 100 mole percent of polytrimethylene carbonate and 0 to about 45 mole percent polylactide, and the biodegradable triblock copolymer overall includes from about 15 to about 25 mole percent of the polytrimethylene carbonate and from about 75 to about 85 mole percent of the polylactide.219-. (canceled)20. The biodegradable triblock copolymer of claim 1 , wherein the B block includes from about 100 mole percent polytrimethylene carbonate and about 0 mole percent polylactic acid.21. The biodegradable triblock copolymer of claim 1 , wherein the B block includes from about 55 to about 95 mole percent polytrimethylene carbonate and about 5 to about 15 mole percent polylactic acid.22. The biodegradable triblock copolymer of claim 1 , wherein the B block includes from about 85 to about 95 mole percent polytrimethylene carbonate and about 5 to about 15 mole percent polylactic acid.23. The biodegradable triblock copolymer of claim 1 , wherein the B block includes from about 85 mole percent polytrimethylene carbonate and about 15 mole percent polylactic acid.24. The biodegradable triblock copolymer of claim 1 , wherein the biodegradable triblock copolymer overall includes about 20 mole percent of the polytrimethylene carbonate and about 80 mole percent of the polylactide.25. The biodegradable ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 1. A residence structure , comprising:a loadable polymeric ...

Class of Anti-Adhesion Hydrogels With Healing Aspects

Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies. 1. A copolymeric hydrogel comprising the polymerization product of a polymer comprising:a) aliphatic ester units,b) a polyethylene oxide, a polypropylene oxide, or both,c) a diisocyanate, andd) a chain extender or cross linker,wherein the polymerization product comprises at least 30% water by weight bound to the hydrogel by hydrogen bonding.2. The copolymeric hydrogel of claim 1 , wherein the polymerization product comprises at least one segment represented by {{Dr[A(Bp)An]Dr}E}m claim 1 , wherein independently for each occurrence claim 1 , A represents an aliphatic ester unit claim 1 , B represents an ethylene oxide group claim 1 , D is the diisocyanate claim 1 , m is an integer greater than or equal to 2 claim 1 , n is an integer ranging from 20 to 50 claim 1 , p is an integer greater than or equal to 1 claim 1 , and r is an integer greater than or equal to 1.3. The copolymeric hydrogel of claim 1 , wherein the copolymer has a dendritic or comb backbone.4. The copolymeric hydrogel of claim 1 , wherein the aliphatic ester is an a polylactic lactic acid claim 1 , a polycarbonate claim 1 , a polycaprolactone claim 1 , a polypropylene carbonate5. The copolymeric hydrogel of claim 1 , ...

Supramolecular biodegradable polymer

The present invention relates to a supramolecular biodegradable polymer comprising a quadruple hydrogen bonding unit (abbreviated herein as “4H-unit”), a biodegradable backbone and hard blocks and a process for preparing such a supramolecular biodegradable polymer. The supramolecular polymer is specifically suitable for biodegradable articles such as biomedical implants that need high strength and/or elasticity, e.g. medical implants in the cardio-vascular field.

POLYMER SYSTEMS AND THEIR APPLICATIONS IN DIAGNOSTICS AND DRUG DELIVERY

The present invention provides a biodegradable “precision polymer system” (poly system) and methods for preparing pharmaceutically effective “precision polymer nanosystems” (polymer nanosystem) for delivery and/or targeting of drugs or drug like compounds. 1. A composition comprising:one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers, wherein the A block is a biodegradable polyester and the B block is polyethylene glycol (PEG); and a plurality of pendent carboxyl groups derived from aromatic or aliphatic dianhydrides incorporated within the block copolymer backbone.2. The composition according to claim 1 , wherein the free pendent carboxyl groups are covalently bonded to a ligand with amine claim 1 , carboxyl or hydroxyl functionality.3. The composition according to claim 1 , further comprising a diamine linker that is conjugated to the carboxyl groups of the block copolymer backbone.4. The composition according to claim 1 , wherein the free amine moiety of the diamine linker is covalently connected to a ligand.5. The composition according to further comprising a drug physically encapsulated or coupled to contrast or near IR agents.6. The composition according to further comprising a single or multiple drugs chemically conjugated to the polymer system forming polymer-drug conjugates.7. The composition according to claim 5 , wherein the drug has limited aqueous solubility or permeability or both.8. The composition according to claim 1 , wherein the composition forms polymer nanosystems or drug conjugates for therapy or diagnosis.9. An aqueous composition comprising the composition of reconstituted in an aqueous vehicle claim 1 , wherein said composition is a uniform colloidal system.10. The composition according to claim 8 , wherein the composition comprises covalently bound ligands on the surface that interact non-competitively with receptors on the cell membranes for receptor-mediated uptake.11. The composition ...

Nucleophile-Triggered Degradable Materials and Methods of Making and Using the Same

Degradable materials including the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Degradable materials include a polymeric and hyperbranched crosslinked material made with oxanorbornadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Methods of making and using degradable materials are included. 1. A degradable material comprising: an oxanorbornadiene compound or derivative thereof; and', 'a multivalent nucleophile-containing compound;, 'the reaction product ofwherein the reaction product is a degradable elastic solid capable of entraining cargo.2. The degradable material of claim 1 , wherein the oxanorbornadiene compound or derivative thereof is divalent or multivalent; andwherein the multivalent nucleophile-containing compound comprises a multivalent nucleophile-containing monomer.3. The degradable material of claim 1 , wherein the multivalent nucleophile-containing compound comprises a thiol-containing multivalent polyethylene glycol.4. The degradable material of claim 1 , wherein the multivalent nucleophile-containing compound has a valency of 4 claim 1 , 5 claim 1 , 6 claim 1 , or 8.5. The degradable material of claim 1 , wherein the multivalent nucleophile-containing compound comprises groups labeled with a probe or cargo.6. The degradable material of further comprising a macromer comprising groups labeled with a probe or cargo.7. The degradable material of further comprising an additive selected from the group consisting of a buffer claim 1 , a catalytic base claim 1 , and a combination thereof.8. The degradable material of claim 1 , wherein the multivalent nucleophile-containing compound is present in a concentration of from 2.5 wt % to 80 wt % of a solution including the multivalent nucleophile-containing compound; andwherein the solution ...

TERMINALLY MODIFIED POLYMERS AND CONJUGATES THEREOF

A terminally modified polymer is provided herein. At least one terminus of the polymer is —O—(CH)-Lor —O—CH—CH(OH)—CH—CR═CRR. L, R, R, and Rare defined herein Also disclosed are terminal conjugates comprising the polymer and a pharmaceutically useful modifier, as well as compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. 3. The terminally modified polymer of claim 1 , wherein each of R claim 1 , R claim 1 , Rand Rindependently is H claim 1 , or unsubstituted or substituted Calkyl.7. The polymer conjugate of claim 4 , wherein M is a protein based recognition molecule having a molecular weight ≦200 kDa and PHF has a molecular weight of about 20 kDa to about 75 kDa.8. The polymer conjugate of claim 4 , wherein M is a protein based recognition molecule having a molecular weight ≧40 kDa and PHF has a molecular weight of about 2 kDa to about 25 kDa.9. A composition comprising the polymer conjugate of and a pharmaceutically suitable carrier. This application is a continuation application of U.S. application Ser. No. 13/934,931, filed Jul. 3, 2013, which claims the benefit of and priority under 35 USC §119(e) to U.S. Provisional Application Nos. 61/668,179, filed Jul. 5, 2012; and 61/794,304, filed Mar. 15, 2013. The contents of each of these applications are hereby incorporated by reference in their entireties.Traditionally, pharmaceuticals have primarily consisted of small molecules that are dispensed orally (as solid pills and liquids) or as injectables. Over the past three decades, formulations (i.e., compositions that control the route and/or rate of drug delivery and allow delivery of the therapeutic agent at the site where it is needed) have become increasingly common and complex. In addition, due to recent advances in genetic and cell engineering technologies, proteins known to exhibit various pharmacological actions in vivo are capable of production in large ...

POLY(THIOKETAL-URETHANE) SCAFFOLDS AND METHODS OF USE

A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. The low-molecular weight thioketal includes 2,2-dimethoxypropane and thioglycolic acid, wherein the thioketal includes at least two hydroxyl terminal groups. The method of forming the biodegradable scaffold includes blending a thioketal with an excess isocyanate, forming a quasi-prepolymer, mixing the thioketal, the quasi-prepolymer, and a ceramic, and then adding a catalyst to form the biodegradable scaffold. The thioketal is a low-molecular weight thioketal having at least two hydroxyl terminal groups. 1. A biodegradable scaffold , comprising:a thioketal; andan isocyanate, where the thioketal is linked to the isocyanate to form the scaffold.2. The scaffold of claim 1 , wherein the thioketal includes at least two functional groups.3. The scaffold of claim 2 , wherein the at least two functional groups are selected from the group consisting of thiol claim 2 , amine claim 2 , hydroxyl claim 2 , and combinations thereof.4. The scaffold of claim 3 , wherein at least two of the functional groups are hydroxyl groups.5. The scaffold of claim 4 , wherein the thioketal is a diol.6. The scaffold of claim 4 , wherein the thioketal is a triol.7. The scaffold of claim 1 , wherein the scaffold further comprises a catalyst.8. The scaffold of claim 7 , wherein the catalyst comprises an amine.9. The scaffold of claim 8 , wherein the catalyst is a solution of triethylene diamine in dipropyleneglycol (TEGOAMIN33).10. The scaffold of claim 1 , wherein the thioketal comprise one or more ether groups.11. The scaffold of claim 1 , wherein the thioketal is a low molecular weight thioketal.12. The scaffold of claim 11 , wherein the low molecular weight thioketal comprises an equivalent weight of at least 95 grams/equivalent.13. The ...

POLYMERIC DHA-CONTAINING BIODEGRADABLE COMPOSITIONS AND SURGICAL BARRIER DEVICES MADE THEREOF

Polymer compositions having the following chemical structure: wherein Lrepresents a polymeric linker having the structure shown connecting ethylene oxide oligomers and their use in surgical devices containing the above composition is also described. 4. The composition of claim 1 , wherein m is an integer of at least 2 and up to 5.5. The composition of claim 1 , wherein m is an integer of at least 3 and up to 10.6. The composition of claim 1 , wherein m is an integer of at least 3 and up to 5.10. The surgical device of claim 7 , wherein m is an integer of at least 2 and up to 5.11. The surgical device of claim 7 , wherein m is an integer of at least 3 and up to 10.12. The surgical device of claim 7 , wherein m is an integer of at least 3 and up to 5.13. The surgical device of claim 7 , wherein the film has a thickness of at least 0.5 mm and up to 5 mm.14. The surgical device of claim 7 , wherein the film has a thickness of at least 1 mm and up to 5 mm.15. The surgical device of claim 7 , wherein the film has a thickness of at least 1 mm and up to 3 mm.19. The method of claim 16 , wherein m is an integer of at least 2 and up to 5.20. The method of claim 16 , wherein m is an integer of at least 3 and up to 10.21. The method of claim 16 , wherein m is an integer of at least 3 and up to 5.22. The method of claim 16 , wherein the film has a thickness of at least 0.5 mm and up to 5 mm.23. The method of claim 16 , wherein the film has a thickness of at least 1 mm and up to 5 mm.24. The method of claim 16 , wherein the film has a thickness of at least 1 mm and up to 3 mm.25. The method of claim 16 , wherein the surgical barrier device exhibits a degradation profile of at least 90% degradation within 4 hours of contact of the surgical barrier device with bodily fluid.26. The method of claim 16 , wherein said surgery comprises abdominal surgery.27. The method of claim 26 , wherein said abdominal surgery comprises a fascial closure.28. The method of claim 26 , wherein said ...

NEW POLYESTER AND COMPOSITIONS CONTAINING IT

This invention relates to a biodegradable polyester which is particularly suitable for use in the manufacture of mass-produced articles characterised by excellent mechanical properties, in particular high tensile strength, elongation and tensile modulus, associated with a high barrier property against oxygen and carbon dioxide. 1. A polyester comprising: a1) 85-65% in moles of units deriving from 2,5-furandicarboxylic acid or an ester thereof;', 'a2) 15-35% in moles of units deriving from at least one saturated dicarboxylic acid selected from the group comprising adipic acid, azelaic acid, sebacic acid, brassylic acid or an ester or derivative thereof;', 'a3) 0-15% in moles of units deriving from at least one aliphatic saturated dicarboxylic acid which is not the saturated dicarboxylic acid in component a2;', 'a4) 0-5% in moles of units deriving from at least one unsaturated aliphatic dicarboxylic acid or an ester thereof;, 'a) a dicarboxylic component comprising with respect to the total dicarboxylic component b1) 95-100% in moles of units deriving from 1,2-ethanediol;', 'b2) 0-5% in moles of units deriving from at least one saturated aliphatic diol which is not 1,2-ethanediol;', 'b3) 0-5% in moles of units deriving from at least one unsaturated aliphatic diol., 'b) a diol component comprising with respect to the total diol component2. The polyester according to claim 1 , in which the said saturated aliphatic dicarboxylic acid (component a3) is selected from saturated C-Cdicarboxylic acids claim 1 , their C-Calkyl esters claim 1 , their salts and their mixtures.3. The polyester according to claim 1 , in which the said saturated dicarboxylic acid in component a2 is azelaic acid.4. The polyester according to claim 3 , in which the said dicarboxylic acid in component a3 is selected from the group consisting of succinic acid claim 3 , 2-ethylsuccinic acid claim 3 , glutaric acid claim 3 , 2-methylglutaric acid claim 3 , adipic acid claim 3 , pimelic acid claim 3 , ...

COMPOSITIONS CONTAINING NEW POLYESTER

This invention relates to biodegradable compositions containing at least a polyester containing 2,5-furandicarboxylic acid and at least a polymer selected from the group consisting of polyhydroxyalkanoates and/or aliphatic and/or aliphatic-aromatic diacid diol polyesters, which is particularly suitable for use in the manufacture of mass-produced articles characterised by excellent mechanical properties, associated with a high barrier property against oxygen and carbon dioxide. 1. A biodegradable composition comprising , with respect to the sum of components i.-iv.:i) 20-60% by weight of at least one biodegradable polyester;ii) 20-70% by weight of at least one biodegradable polymer which is not the polyester i., selected from the group consisting of polyhydroxyalkanoates and/or aliphatic and/or aliphatic-aromatic diacid diol polyesters which are not polyester i., and mixtures thereof;iii) 0-50% by weight of at least one filler;iv) 0-30% by weight of plant fibres.wherein the biodegradable polyester i. comprises: a1) 85-65% in moles of units deriving from 2,5-furandicarboxylic acid or an ester thereof;', 'a2) 15-35% in moles of units deriving from at least one saturated dicarboxylic acid selected from the group consisting of adipic acid, azelaic acid, succinic acid, sebacic acid, brassylic acid or an ester or derivative thereof, preferably azelaic acid;', {'sub': 2', '24', '4', '13', '4', '11, 'a3) 0-15% in moles of units deriving from at least one aliphatic saturated dicarboxylic acid which is not the saturated dicarboxylic acid in component a2 and is preferably selected from the group consisting of saturated C-C, preferably C-C, more preferably C-C, dicarboxylic acids, or esters thereof;'}, 'a4) 0-5% in moles of units deriving from at least one unsaturated aliphatic dicarboxylic acid or an ester thereof;, 'a) a dicarboxylic component comprising, with respect to the total dicarboxylic component b1) 95-100% in moles, of units deriving from 1,2-ethanediol;', 'b2) 0-5% ...

BIODEGRADABLE SUPER-SPREADING, ORGANOMODIFIED TRISILOXANE

The invention relates to polyether-modified siloxanes which are both superspreading and readily biodegradable. In particular, the invention is directed to a composition including polyether-modified siloxanes of formula (I) 1. A composition comprising polyether-modified siloxanes of formula (I){'br': None, 'sub': a', 'b', 'c, 'MDD′\u2003\u2003Formula (I)'}{'sup': 1', '1', '1', '2, 'sub': 3', '1/2', '2', '2/2', '2/2, 'with M is RSiO, D is RSiO, D′ is RRSiO,'}wherea is 2b is between 0 and 0.1,c is between 1.0 and 1.15,{'sup': '1', 'Rare independently hydrocarbyl having 1 to 8 carbon atoms,'}{'sup': '2', 'claim-text': {'br': None, 'sup': 3', '5, 'sub': 2', '2', 'm', '2', '3', 'n, '—RO[CHCHO][CHCH(CH)O]R\u2003\u2003Formula (II)'}, 'Rare independently a polyether radical of the formula (II)'}wherem is from 3.4 to 11.0,n is from 2.5 to 8.0,and wherein m/n is from 1.9 to 2.8,{'sup': '3', 'Rare independently divalent hydrocarbyl radicals having 2 to 8 carbon atoms,'}{'sup': '5', 'Ris hydrogen,'}the polyether-modified siloxanes of formula (I) having a biodegradability of from 60% to 100%.2. The composition according to claim 1 , wherein the sum total of m+n is from 9 up to 19.3. The composition according to claim 1 , wherein a 0.1 percent by weight solution of the polyether-modified siloxanes of formula (I) in water has a spreading area of from 10 to 60 cm.4. The composition according to claim 1 , wherein the polyether-modified siloxanes of the formula (I) have an index c between 1 and 1.05 claim 1 , where the m/n ratio is 0.8 to 2.8 and a 0.1% by weight solution of these siloxanes in water has a spreading area of 15 to 60 cm.5. The composition according to claim 1 , wherein the polyether-modified siloxanes of the formula (I) have a biodegradability of greater than 60% claim 1 , and the index c is additionally between 1 and 1.05 claim 1 , where the molar mass of the polyether radical M(PE) is between 520 g/mol and 660 g/mol claim 1 , the Rradical is hydrogen and a 0.1% by ...

METHOD FOR PRODUCING BIODEGRADABLE POLYESTER RESIN AND BIODEGRADABLE RESIN PRODUCED THEREFROM

The present invention relates to a method for using a combination of two kinds of thermal stabilizers in a production process in order to improve the thermal stability of biodegradable polyester resins, and to biodegradable polyester resin produced therefrom. In said method, two kinds of thermal stabilizers improve thermal stability by acting complementarily with each other. Thus, a high temperature reaction is possible, and due to an increase in the reactivity, the reaction time is shortened and the molecular weight is increased. In addition, the obtained resin can provide high quality products, since the acid value thereof is reduced to improve the hydrolysis resistance thereof, and the chromaticity thereof is enhanced to thereby be capable of preventing a yellowing phenomenon of the final product. 1. A method of preparing a biodegradable resin , comprising:esterifying 1,4-butanediol and one or more dicarhoxylic acids selected from the group consisting of terephthalic acid (TA) or a derivative thereof and an aliphatic dicarboxylic acid having a backbone consisting of 2 to 6 carbon atoms by using a thermal stabilizer in which one or more compounds selected from a first group consisting of phosphate-based compounds and one or more compounds selected from a second group consisting of phosphite-based compounds and an acrylate-based compound are combined; andpolycondensing a product of the esterification reaction.2. The method of preparing a biodegradable resin according to claim 1 , wherein the first group includes triphenyl phosphate claim 1 , trimethyl phosphate claim 1 , triethyl phosphate claim 1 , isopropyl acid phosphate claim 1 , diisopropyi acid phosphate claim 1 , butyl acid phosphate claim 1 , octyl acid phosphate claim 1 , dioctyl acid phosphate claim 1 , isodecyl acid phosphate claim 1 , diisodecyl acid phosphate claim 1 , tridecanol acid phosphate claim 1 , and bis(tridecanol acid)phosphate.3. The method of preparing a biodegradable resin according to ...

METHOD FOR MANUFACTURING POLYDIOXANONE PARTICLES FOR FILLER

The present invention relates to a method for manufacturing polydioxanone particles (PDO) for a filler, more particularly to a method for manufacturing polydioxanone particles, which includes a step of mixing a solution of polydioxanone dissolved in a perfluoroalcohol with a polymer emulsion containing a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer at a predetermined ratio to generate polydioxanone particles and then recovering the polydioxanone particles through aging and washing. The polydioxanone particles manufactured by the manufacturing method of the present invention can be favorably used as an injection for regenerating skin tissues. 1. A method for manufacturing polydioxanone particles for a filler , comprising:a) preparing a polydioxanone solution by dissolving polydioxanone in a perfluoroalcohol;b) preparing a polymer emulsion by mixing and stirring a polyethylene oxide-polypropylene oxide-polyethylene oxide terpolymer, an acid, water and a surfactant;c) generating polydioxanone particles by mixing the polymer emulsion with the polydioxanone solution and stirring the mixture;d) aging the polydioxanone particles by adding a stabilizer to the dispersion in which the particles are dispersed and stirring the same; ande) recovering the polydioxanone particles and purifying them by washing.2. The method for manufacturing polydioxanone particles for a filler according to claim 1 , wherein the perfluoroalcohol in a) is a C-Calcohol compound substituted with 3-13 fluorine atoms.3. The method for manufacturing polydioxanone particles for a filler according to claim 2 , wherein the perfluoroalcohol in a) is 1 claim 2 ,1 claim 2 ,1 claim 2 ,3 claim 2 ,3 claim 2 ,3-hexafluoro-2-propanol.4. The method for manufacturing polydioxanone particles for a filler according to claim 1 , wherein the concentration of the polydioxanone in the polydioxanone solution in a) is 1.0-5.0 wt %.5. The method for manufacturing polydioxanone particles for a filler ...

BIODEGRADABLE THERMO-RESPONSIVE POLYMERS AND USES THEREOF

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker. 4. The compound of claim 1 , wherein the value of [(m+m)/p] is a number between 0 and 8.5. The compound of claim 1 , wherein the compound has a lower critical solution temperature of about 6° C. to about 80° C.6. The compound of claim 5 , wherein the lower critical solution temperature is about 25° C. to about 45° C.79-. (canceled)10. The compound of claim 1 , wherein X is C-Cn-alkyl.11. The compound of claim 1 , wherein p is an integer between 3 and 50.1220-. (canceled)2225-. (canceled)26. The compound of claim 21 , wherein{'sub': '1', 'each nmay be the same or different and is an integer between 2 and 4;'}{'sub': '1', 'each mmay be the same or different and is an integer between 0 and 2;'}{'sub': 2', '5, 'each X may be the same or different and is C-Calkyl;'}{'sub': '2', 'each mmay be the same or different and is an integer between 0 and 3; and'}p is an integer between 3 and 100,2729-. (canceled)3185-. (canceled)86. A method for treating cancer in a subject the method comprising administering to a subject a therapeutic amount of the compound of claim 1 , wherein the cancer comprises breast cancer claim 1 , non-small cell lung cancer claim 1 , pancreatic cancer claim 1 , acute lymphoblastic leukemia (ALL) claim 1 , acute myeloid leukemia (AML) claim 1 , gastric cancer claim 1 , Hodgkin lymphoma claim 1 , neumblastoma claim 1 , non-Hodgkin lymphoma claim 1 , ovarian cancer claim 1 , small cell lung cancer claim 1 , soft tissue and bone sarcomas claim 1 , thyroid ...

Self-assembled residence devices and related methods

Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first attachment point that attaches to a second attachment point on another structure of the plurality of structures. The aggregate structure may be sized and shaped to maintain an in vivo position relative to an internal orifice of a subject. The attachment between the first and second attachment points may degrade after a period of time.

Residence structures and related methods

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

Tagged poly(ester amide urethane)s, nanoparticles formed from same, and uses thereof

Provided are polymers (e.g., polymeric materials), nanoparticles comprising one or more of the polymers, and compositions. A polymer may be in the form of a nanoparticle. A polymer can be linear or branched. A polymer includes one or more poly(ester urea) segment, optionally, one or more poly(urethane) segment, optionally, one or more diol segment, optionally, one or more poly(ethylene glycol) segment, and, optionally, one or more terminal/end group. A polymer (e.g., a polymeric material) may include a branching moiety. For example, a composition includes one or more polymer. In an example, polymers and nanoparticles can be used to deliver a drug (e.g., gambogic acid) to an individual (e.g, who has been diagnosed with or is suspected of having cancer and/or a viral infection).

BIODEGRADABLE COMPOSITE MATERIAL HAVING IMPROVED MECHANICAL PROPERTIES USING NATURAL POLYMER NANOFIBER AQUEOUS DISPERSION AND METHOD OF PRODUCING THE SAME

A biodegradable composite material which is produced by polymerizing a mixture of an aqueous dispersion of a natural polymer nanofiber including any one or more of a chitin nanofiber and a cellulose nanofiber, a dicarboxylic acid or a derivative thereof, and a diol. The biodegradable composite material has excellent biodegradable and mechanical properties. 1. A biodegradable composite material produced by polymerizing a mixture including:an aqueous dispersion of a natural polymer nanofiber including any one or more selected from the group consisting of a chitin nanofiber and a cellulose nanofiber;a dicarboxylic acid or a derivative thereof; anda diol.2. The biodegradable composite material of claim 1 , wherein an amount of the natural polymer nanofiber in the aqueous dispersion of the natural polymer nanofiber is 0.005 to 2 wt % claim 1 , based on a total of 100 wt % of the biodegradable composite material.3. The biodegradable composite material of claim 1 , wherein a concentration of the natural polymer nanofiber in the aqueous dispersion of the natural polymer nanofiber is 0.1 to 50 wt %.4. The biodegradable composite material of claim 1 , wherein the natural polymer nanofiber has a diameter of 1 to 200 nm and a length of 100 nm to 100 μm.5. The biodegradable composite material of claim 1 , wherein the biodegradable composite material is produced by polymerizing the mixture further comprising: any one or more selected from the group consisting of a tri- or higher functional alcohol; a tri- or higher functional carboxylic acid or a derivative thereof; and a tri- or higher functional hydroxy acid or a derivative thereof.8. A method of producing a biodegradable composite material claim 1 , the method comprising:preparing a mixed dispersion including an aqueous dispersion of a natural polymer nanofiber including any one or more selected from the group consisting of a chitin nanofiber and a cellulose nanofiber, a dicarboxylic acid or a derivative thereof, and a diol; ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179-. (canceled)80. A gastric residence structure , comprising: ...

SKIN EXTERNAL PREPARATION AND SKIN IRRITATION-REDUCING METHOD

Provided is a skin external preparation including a drug and nanometer-size molecular assemblies. The molecular assemblies contain an amphiphilic block copolymer having a hydrophilic block chain including a sarcosine-derived structural unit and a hydrophobic block chain including a hydroxy acid-derived structural unit. The skin external preparation according to the present invention may reduce skin irritation caused by the drug, be very safe, and have excellent pharmacological effects, even when a drug that is generally difficult to be transdermally administered due to its strong skin irritation is contained therein. 1. A skin external preparation , comprising:a drug; andnanometer-size molecular assemblies,wherein the molecular assemblies include an amphiphilic block copolymer having a hydrophilic block chain including a sarcosine-derived structural unit and a hydrophobic block chain including a hydroxy acid-derived structural unit.2. The skin external preparation according to claim 1 , wherein the hydrophilic block chain has 20 or more of sarcosine-derived structural units.3. The skin external preparation according to claim 1 , wherein the hydrophobic block chain has 10 or more of hydroxy acid-derived structural units.4. The skin external preparation according to claim 1 , wherein a hydroxy acid of the hydroxy acid-derived structural unit is an aliphatic hydroxy acid.5. The skin external preparation according to claim 1 , wherein the molecular assemblies are particles having an average particle diameter of 10 to 300 nm.6. The skin external preparation according to claim 1 , wherein the drug is statin.7. The skin external preparation according to claim 1 , wherein the drug is an Alzheimer-type dementia treatment drug.8. The skin external preparation according to claim 1 , wherein the molecular assemblies further include a hydrophobic polymer.9. The skin external preparation according to claim 1 , wherein the molecular assemblies contain the drug.10. The skin ...

RING-OPENING POLYMERIZATION METHOD FOR CYCLIC MONOMER

The present disclosure belongs to the field of organic synthesis, and particularly relates to a ring-opening polymerization method for a cyclic monomer. A specific solution is that a Lewis acid-base pair is used to catalyze ring-opening polymerization of the cyclic monomer in the presence of an initiator. By using the Lewis acid-base pair as a catalyst, on one hand, a range of a ring-opening polymerization catalyst is widened, and on the other hand, this catalyst achieves a higher catalytic efficiency and is milder in comparison with previously reported strong acid or strong base catalysts. In addition, through a bifunctional activation mechanism, this catalyst system activates the monomer and simultaneously activates the initiator or a chain end, and has the characteristics of high efficiency in comparison with the reported monomer activation mechanism or chain end activation mechanism. By adopting the catalyst, a polyester product with a target molecular weight can be synthesized in a controlled manner as required, with a narrower molecular weight distribution index, a high product yield, a high product conversion rate and no monomer or metal residues. 4. The method according to claim 1 , wherein ring-opening polymerization conditions for the cyclic monomer are as follows: a reaction is carried out in the presence of an organic solvent or in the absence of a solvent in an anhydrous and oxygen-free environment claim 1 , and a polymer is precipitated by using a precipitation solvent after the reaction is ended claim 1 ,wherein, a reaction temperature is 20° C. to 110° C. when the reaction is carried out in the presence of the organic solvent, and a reaction temperature is 80° C. to 200° C. when the reaction is carried out in the absence of the solvent.5. The method according to claim 4 , wherein when the reaction is carried out in the presence of the organic solvent claim 4 , when the organic solvent is dichloromethane claim 4 , the reaction temperature is 20° C. to ...

METHOD FOR CONTINUOUSLY PREPARING BIODEGRADABLE ALIPHATIC/AROMATIC POLYESTER COPOYMER

Provided is a method of continuous preparation of a biodegradable aliphatic/aromatic polyester copolymer, the method including: performing a first esterification reaction of an aliphatic dihydroxy compound and an aliphatic dicarboxylic acid at a temperature of 185° C. or less; continuously performing a second esterification reaction of a reaction product obtained by the first esterification reaction; obtaining a pre-polymer by continuously performing a first polycondensation reaction of a reaction product obtained by the second esterification reaction; and continuously performing polycondensation reaction of the pre-polymer, wherein an aromatic carboxylic acid is added to a reactor in which the first esterification reaction or the second esterification reaction is performed, to prepare the biodegradable aliphatic/aromatic polyester copolymer. According to the method of continuous preparation of the biodegradable aliphatic/aromatic polyester copolymer as described above, the amount of the aliphatic dihydroxy compound used, which is a starting material, is reduced and accordingly, manufacturing costs are reduced. 1. A method of continuously preparing a biodegradable aliphatiac/aromatic polyester copolymer , the method comprising:performing a first esterification reaction of an aliphatic dihydroxy compound with an aliphatic dicarboxylic acid at a temperature of 185° C. or less;continuously performing a second esterification reaction of a reaction product obtained from the first esterification reaction;obtaining a prepolymer by continuously performing a first polycondensation reaction of a product obtained from the second esterification reaction; andcontinuously performing polycondensation reaction of the prepolymer,wherein an aromatic carboxylic acid is added to the step of performing the first esterification reaction or the step of continuously performing the second esterification reaction to prepare the biodegradable aliphatic/aromatic polyester copolymer.2. The ...

POLYMER COMPOSITIONS

The invention relates to novel a high-volume swelling hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, and/or a semi-interpenetrating network and/or simple cross-linked arrangement of a plurality of one or more species of hydrophilic polymers, optionally together with one or more biocompatible polymers and optionally together with one or more plasticising agents, characterised in that at least some of the pores are at least partially collapsed and/or flattened, and further characterised in that the interpenetrating network and/or semi-interpenetrating network and/or cross-linked arrangement which defines the collapsed and/or flattened pores is substantially unbroken. The invention also relates to a process for preparing such hydrogels, and to their use as an appetite suppressant. 16.-. (canceled)7. A process for preparing a compressed hydrogel comprising the steps:a) providing an initial hydrogel which comprises a plurality of pores which are defined by an interpenetrating network, or a semi-interpenetrating network or a simple cross-linked structure, and which is made from a composition comprising one or more hydrophilic polymers;b) treating the initial hydrogel with heat or water vapor or both and applying a compressive force suitable to reduce the volume of at least some of the pores of the initial hydrogel thereby to yield a compressed hydrogel.8. The process according to claim 7 , wherein the initial hydrogel comprises one or more additional ingredients selected from additional polymers and plasticizing agents.9. (canceled)10. The process according to claim 7 , wherein the treatment conditions in step b) comprise treating the initial hydrogel with steam.11. The process according to claim 7 , wherein the size of one or more of the pores of the initial hydrogel is reduced by at least a factor of 2 claim 7 , following the application of the compressive force in step b).12. The process according to claim 7 , wherein ...

HYDROPHILIC POLYMERS WITH ANTIMICROBIAL FUNCTIONALITIES

Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality. 1. A chemical compound , comprising:an ionene unit comprising a cation distributed along a degradable backbone, the degradable backbone comprising a terephthalamide structure, wherein the ionene unit has antimicrobial functionality; anda hydrophilic functional group covalently bonded to the ionene unit, wherein the chemical compound has carbohydrate mimetic functionality.2. The chemical compound of claim 1 , wherein the cation is selected from a group consisting of a nitrogen cation and a phosphorus cation.3. The chemical compound of claim 2 , wherein the cation is selected from a second group consisting of a protonated secondary amine cation claim 2 , a protonated tertiary amine cation claim 2 , a quaternary ammonium cation and an imidazolium cation.4. The chemical compound of claim 3 , wherein the hydrophilic functional group comprises a plurality of hydroxyl groups.5. The chemical compound of claim 4 , further comprising a hydrophobic functional group covalently bonded to the cation and the hydrophilic functional group.6. The chemical compound of claim 5 , wherein the hydrophilic functional group comprises a second cation.8. A chemical compound claim 5 , comprising:an ionene unit comprising a cation distributed along a degradable backbone, the degradable backbone comprising a terephthalamide structure, wherein the ionene unit has antimicrobial functionality; anda ...

POLYMERS WITH ANTIMICROBIAL FUNCTIONALITIES

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality. 1. A polymer comprising:a repeating ionene unit comprising a cation distributed along a degradable backbone, and the degradable backbone comprising a terephthalamide structure, wherein the repeating ionene unit has antimicrobial functionality.2. The polymer of claim 1 , wherein the cation is selected from a group consisting of a nitrogen cation and a phosphorus cation.3. The polymer of claim 2 , wherein the cation is a nitrogen cation selected from a second group consisting of a protonated secondary amine cation claim 2 , a protonated tertiary amine cation claim 2 , a quaternary ammonium cation and an imidazolium cation.4. The polymer of claim 2 , wherein the cation is covalently bonded to a hydrophobic functional group.6. The polymer of claim 5 , wherein the cation is a nitrogen cation selected from a third group consisting of a protonated secondary amine cation claim 5 , a protonated tertiary amine cation claim 5 , a quaternary ammonium cation and an imidazolium cation.7. The polymer of claim 6 , wherein the cation is the quaternary ammonium cation.8. The polymer of claim 6 , wherein the cation is the imidazolium cation.9. The polymer of claim 6 , wherein the terephthalamide structure is derived from polyethylene terephthalate.11. A method comprising:dissolving a plurality of amine monomers with an electrophile in a solvent, the plurality of amine monomers comprising a degradable backbone, and the degradable backbone comprising a terephthalamide structure; andpolymerizing the plurality of amine monomers and the electrophile to form a repeating ...

RESIDENCE STRUCTURES AND RELATED METHODS

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time. 179.-. (canceled)80. A gastric residence structure comprising an ...

In-Situ Forming Foam for the Treatment of Vascular Dissections

Systems and methods related to polymer foams for the treatment of blood vessel dissections are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to or within a dissection caused by an intimal tear in a blood vessel, sealing the dissection and preventing further perfusion thereof. In some embodiments, the polymer foam can be formed within a body cavity (i.e., in-situ foam formation). The foam may be used to fill the dissection as a thrombosing agent. In addition, the foam may be used in conjunction with medical devices such as stents, stent-grafts, balloons, and catheters.

DEGRADABLE HYDROGEL WITH PREDICTABLE TUNING OF PROPERTIES, AND COMPOSITIONS AND METHODS THEREOF

The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner is achieved via a simple but versatile hydrogel platform that allows formulation of hydrogels with predictable disintegration time from within 2 days to >250 days yet comparable macroscopic physical properties. 2. (canceled)3. The hydrogel of claim 1 , wherein the first set of macromers and/or the second set of macromers are hydrophilic macromers.4. The hydrogel of claim 3 , wherein the first set of macromers are a first poly(ethylene glycol) macromer and the second set of macromers is a second poly(ethylene glycol) macromer.5. The hydrogel of claim 3 , whereinthe first set of macromers comprises four first reactive end groups; andthe second set of macromers comprises four second reactive end groups.6. The hydrogel of claim 5 , wherein four first reactive end groups are terminal azide groups claim 5 , and four second reactive end groups are terminal alkyne groups.9. The hydrogel of claim 8 , wherein Rcomprises a group selected from dibenzylcyclooctyne (DBCO) claim 8 , dibenzocyclooctyne-amine claim 8 , dibenzocyclooctyne-N-hydroxysuccinimidyl ester claim 8 , (1R claim 8 ,8S claim 8 ,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethanol claim 8 , (1R claim 8 ,8S claim 8 ,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl N-succinimidyl carbonate claim 8 , dibenzocyclooctyne-maleimide groups.10. The hydrogel of claim 9 , wherein bioorthogonally crosslinking the first set of macromers and the second set of macromers is performed via copper-free claim 9 , strain-promoted azide-alkyne cycloaddition or copper-catalyzed azide-alkyne cycloaddition.12. (canceled)13. The hydrogel composition of claim 11 , wherein the first set of ...

Polymer for tissue engineering

The invention relates to a polymer for tissue engineering from biodegradable polyphosphazenes, having photopolymerizable side groups, wherein the side groups of the polyphosphazenes are formed exclusively from amino acids and/or amino acid derivatives, which are bonded to the backbone of the polyphosphazene via the amino group of the amino acid and to a spacer attached to the acid group with a carbon chain of length m, which has a vinyl group at the free end, wherein m=0 to m=10.

COMPOSITION FOR WELL DRILLING COMPRISING REACTIVE METAL AND DEGRADABLE RESIN COMPOSITION, MOLDED PRODUCT FOR WELL DRILLING, AND METHOD FOR WELL DRILLING

Provided are a molded product for well drilling comprising a reactive metal and a degradable resin composition that promotes a degradation reaction of the reactive metal, preferably a degradable resin composition comprising a degradable resin that generates acid upon degradation or a degradable resin composition containing a degradable resin and an inorganic material or an organic material that promotes degradation of the reactive metal; a molded product for well drilling which is a downhole tool or a downhole tool member; and a method for well drilling that uses said molded product for well drilling. 1. A composition for well drilling comprising a reactive metal and a degradable resin composition promoting degradation of the reactive metal.2. The composition for well drilling according to claim 1 , wherein the degradable resin composition comprises a degradable resin generating acid upon degradation.3. The composition for well drilling according to claim 1 , wherein the degradable resin composition comprises an aliphatic polyester.4. The composition for well drilling according to claim 3 , wherein the aliphatic polyester is one or more selected from the group consisting of polyglycolic acid claim 3 , polylactic acid claim 3 , and glycolic acid-lactic acid copolymer.5. The composition for well drilling according to claim 1 , wherein the degradable resin composition comprises a degradable resin and an inorganic material or an organic material promoting degradation of the reactive metal.6. The composition for well drilling according to claim 5 , wherein the inorganic material promoting degradation of the reactive metal is an inorganic salt.7. (canceled)8. The composition for well drilling according to claim 5 , wherein the degradable resin comprises a water-soluble resin.9. (canceled)10. (canceled)11. The composition for well drilling according to claim 1 , wherein the degradable resin composition comprises a filler.12. The composition for well drilling according to ...

POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers. 3. The polymer of claim 2 , wherein A is CH claim 2 , Y is selected from the group consisting of (CH) claim 2 , (CH) claim 2 , CHOCH claim 2 , (CH) claim 2 , CHCH═CHCH claim 2 , (CH) claim 2 , (CH) claim 2 , and (CH).4. The polymer of claim 2 , wherein A is or CHCH claim 2 , Y is selected from the group consisting of (CH) claim 2 , (CH) claim 2 , CHOCH claim 2 , (CH) claim 2 , CHCH═CHCH claim 2 , (CH) claim 2 , (CH) claim 2 , and (CH).6. The polymer of claim 5 , wherein B is —O—CO—CHCH.7. The polymer of claim 5 , wherein B is —O—CO—CHCHCH.8. The polymer of claim 5 , wherein B is —O—CO—CHOCH.9. A polymer composition comprising a biocompatible polymer of . This application is a continuation-in-part application of U.S. patent application Ser. No. 15/208,709, filed on Jul. 13, 2016, which is a divisional application of U.S. patent application Ser. No. 13/757,752, filed on Feb. 2, 2013, now U.S. Pat. No. 9,416,090, which claims priority under 35 U.S.C. § 119(e) to U.S. Provisional Patent Application Ser. No. 61/726,321, filed on Nov. 14, 2012, and Ser. No. 61/594,380, filed on Feb. 3, 2012. All of the above applications prior to the present application are hereby incorporated by reference in their entirety.The present invention relates to new classes of monomeric phenol compounds useful for preparation of biocompatible polymers and ...

Thermally adhesive flexible polylactic acid resin composition

The present invention relates to a polylactic acid resin composition which has a low glass transition temperature, fusion temperature, and enthalpy of fusion, can be crystallized under commercially meaningful processing conditions, has good film processability such as extrusion properties, has excellent storage stability, and is highly biodegradable. The polylactic acid resin composition comprises a block copolymer comprising a hard segment and a soft segment, the hard segment comprising polylactic acid repeat units, and the soft segment comprising polyurethane polyol repeat units which have polyether-based polyol repeat units linearly connected via a urethane bond, wherein the soft segment is contained by 5% to 35% by weight based on the weight of the block copolymer, and the polylactic acid repeat units include poly(L-lactic acid) repeat units and poly(D-lactic acid) repeat units by a molar ratio of 94:6 to 88:12.

BONE REPAIR MATERIAL

Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores. 1. A method for preparing a bone repair material , the method comprising:a. mixing an aqueous solution comprising a first precursor with an aqueous solution comprising a second precursor to form a mixture, the total concentration of the first precursor and the second precursor in the mixture being less than the equilibrium concentration of a hydrogel;b. adding the mixture to a porous block-shaped scaffold, the scaffold being made of a synthetic ceramic material and comprising interconnected macropores having a diameter of at least 100 μm, the scaffold having a total porosity in a range of from 80 to 95%; andc. removing water from the porous block-shaped scaffold containing the mixture to allow a Michael type addition reaction between the first precursor and the second precursor to produce a crosslinked polyethylene glycol hydrogel within the porous block-shaped scaffold.2. The method according to claim 1 , wherein the total concentration of the first precursor and the second precursor in the mixture is less than 5% by weight.3. The method according to claim 2 , wherein the first precursor is present in the mixture at a concentration in a range of from 0.5 to 4.5% by weight claim 2 , and the total concentration of the first precursor and the second precursor in the mixture is at least 2% by weight.4. The method according to claim 2 , wherein the second precursor is present in the mixture at a concentration in a range of from 0.5 to 4.5% by weight claim 2 , and the total concentration of the first precursor and the ...

MODIFIED POLYLACTIC ACID, POLYMERIZED MODIFIED POLYLACTIC ACID, AND METHODS AND APPARATUSES FOR MANUFACTURING THE SAME

Provided are: a modified polylactic acid that is environmentally friendly, potentially usable as a battery material of a secondary battery or the like, and obtained by chemically derivatizing polylactic acid having an L-lactide structure generated or obtained in the manufacture of polylactic acid; a polymerized modified polylactic acid obtained by further polymerizing this modified polylactic acid; and methods and apparatuses for manufacturing the modified polylactic acid and the polymerized modified polylactic acid. The present invention uses: a modified polylactic acid including a structure represented by general formula (1) below (in formula (1), R1 and R2 are structures containing a metal element and can be the same or different, AA and BB are CC or structures containing a metal element in R3 and R4 and can be the same or different, and R5 is a structure containing a metal element); a polymerized modified polylactic acid; and methods and apparatuses for manufacturing the modified polylactic acid and the polymerized modified polylactic acid. 3. The modified polylactic acid according to claim 1 , wherein in a modified polylactic acid represented by at least one of formulas (1) and (2) claim 1 , a metal element is an element selected from the group consisting of vanadium claim 1 , nickel claim 1 , iron claim 1 , aluminum claim 1 , titanium claim 1 , cerium claim 1 , silicon claim 1 , zirconium claim 1 , ruthenium claim 1 , manganese claim 1 , chromium claim 1 , cobalt claim 1 , platinum claim 1 , thorium claim 1 , palladium claim 1 , and tin.4. The modified polylactic acid according to claim 1 , manufactured by obtaining polylactic acid including a lactide structure and having a weight average molecular weight of 2 claim 1 ,000 to 20 claim 1 ,000 daltons by decomposing polylactic acid by an alkali catalyst claim 1 , aminating the lactide structure by adding an aminated metal compound to polylactic acid including the L-lactide claim 1 , and adding a functional group ...

SYNTHESIS OF CRYSTALLINE POLYMERS FROM CYCLIC DIOLIDES

Biodegradable polymers with advantageous physical and chemical properties are described, as well as methods for making such polymers. In one embodiment, a new chemical synthesis route to technologically important biodegradable poly(3-hydroxybutyrate) (P3HB) with high isotacticity and molecular weight required for a practical use is described. The new route can utilize racemic eight-membered cyclic diolide (rac-DL), meso-DL, or a rac-DL and meso-DL mixture, derived from bio-sourced dimethyl succinate, and enantiomeric (R,R)-DL and (S,S)-DL, optically resolved by metal-based catalysts. With a stereoselective racemic molecular catalyst, the ROP of rac-DL under ambient conditions produces rapidly P3HB with essentially perfect isotacticity ([mm]>99%), high crystallinity and melting temperature (T=171° C.), as well as high molecular weight and low dispersity (M=1.54×10g/mol, Ð=1.01). 2. The polymer of wherein the polymer comprises at least 99% isotactic triads with respect to the stereocenters of substituents R on polymer chain.3. The polymer of wherein the molecular weight Mis at least about 100 kDa.4. The polymer of wherein the polymer has a melting temperature claim 1 , T claim 1 , of at least 170° C.5. A composition comprising polymers of wherein the composition comprises approximately equal amounts of polymers having isotactic triads of (R) stereochemical configurations and polymers having isotactic triads of (S) stereochemical configurations.6. The composition of wherein the dispersity index M/Mof the polymers is less than 1.2.7. A copolymer comprising a polymer of and a polyester of lactone monomers.14. The method of wherein Formula I comprises at least 95% isotactic triads with respect to the stereocenters of substituents R on the polymer chain claim 13 , wherein the at least 95% isotactic triads (mm) have consecutive (R) stereochemical configurations or consecutive (S) stereochemical configurations.15. The method of wherein the monomer of Formula V is a racemic ...

Biocompatible, Biodegradable Polyurethane Materials With Controlled Hydrophobic to Hydrophilic Ratio

The biocompatible, biodegradable materials in the solid and/or liquid form are based on segmented linear polyurethanes and/or segmented crosslinked polyurethanes based on A) one or more biocompatible polyols susceptible to hydrolytic and/or enzymatic degradation having a molecular weight of 100 to 20,000 dalton and a number of active hydroxyl groups per molecule (functionality) of at least two or higher: B) one or more diisocyanates and/or triisocyanates; and C) one or more low molecular weight chain extenders having a molecular weight of 18 to 1000 dalton and the functionality of at least two or higher.

FUNCTIONAL BIODEGRADABLE POLYMERS

Biodegradable polyesters are made by synthesizing copolymers derived from biodegradable hydroxyacid monomers as well as from hydroxyacid monomers containing a functional group such as an azide group, a halogen group, a thioacetate group, and the like. Preferably, the functionalized biodegradable polyester copolymers are derived from a functionalized hydroxyacid such as a homolog of lactic acid and/or glycolic acid with the copolyester thus containing functional groups on the backbone thereof. These biodegradable polyesters can be utilized wherever biodegradable polyesters are currently used, and also serve as a polymer to which various medical and drug delivery systems can be attached. 115-. (canceled)16. A process for synthesizing an α-halogenated copolyester comprising:polymerizing one or more α-halogenated hydroxyacids with co-monomers that include(i) one or more diols containing from 2 to about 10 carbon atoms and one or more dicarboxylic acids containing from 2 to about 15 carbon atoms;(iii) one or more hydroxyacids containing from 2 to about 20 carbon atoms, or (i) one or more diols containing from 2 to about 10 carbon atoms, one or moredicarboxylic acids containing from 2 to about 15 carbon atoms, and one or more hydroxyacids containing from 2 to about 20 carbon atoms.17. The process of claim 16 , wherein at least one of the co-monomers is a hydroxyacid selected from glycolic acid claim 16 , galactaric acid claim 16 , hydroxypropionic acid claim 16 , lactic acid claim 16 , hydroxybutyric acid claim 16 , hydroxyisobutyric acid claim 16 , hydroxy methylbutyric acid claim 16 , bis(hydroxymethyl)propionic acid claim 16 , hydroxyoctadecanoic acid claim 16 , di-tert-butyl hydroxybenzoic acid claim 16 , benzilic acid claim 16 , hydroxyl fluorenecarboxylic acid claim 16 , hydroxydecanoic acid claim 16 , hydroxynaphthalenecarboxylic acid claim 16 , hydroxybenzenedicarboxylic acid claim 16 , hydroxymethylbenzoic acid claim 16 , hydroxyphenylacetic acid claim 16 , ...

METHODS FOR PRODUCING POLYASPARTIC ACIDS

The present invention relates to methods for producing polyaspartic acids with a weight-average molecular weight (Mw) of from 6,000 to 15,000 g/mol. The invention also relates to polyaspartic acids which can be obtained by the method according to the invention, to a composition containing the polyaspartic acids, and to the use thereof as scale inhibitors, dispersants and as an additive in dishwashing agents, detergents or cleaning agents. 118.-. (canceled)19. A method for producing polyaspartic acids with a weight-average molecular weight (Mw) of 6000 to 15 000 g/mol , comprising the following steps: (a) aspartic acid in the presence of', '(b) 1 to 15 mol % of methanesulfonic acid, based on the amount of aspartic acid used in (a)', 'at a temperature of 170° C. to 230° C. for a time period of 1 minute to 50 hours;, '(i) polycondensation of'}(ii) subsequent hydrolysis of the polycondensates with addition of a base; and(iii) optional acidification of the salt of polyaspartic acid obtained in (ii) with mineral acids or acidic ion exchangers.20. The method according to claim 19 , wherein 2 to 13 mol % of methanesulfonic acid are used in step (i) (b) claim 19 , based on the amount of aspartic acid used in (a).21. The method according to claim 19 , wherein 3 to 10 mol % of methanesulfonic acid are used in step (i) (b) claim 19 , based on the amount of aspartic acid used in (a).22. The method according to claim 19 , wherein the polycondensation in step (i) is carried out at a temperature of 190° C. to 220° C.23. The method according to claim 19 , wherein the quotient of weight-average molecular weight (Mw) to number-average molecular weight (Mn) of the polyaspartic acid produced is not greater than 3.24. The method according to claim 23 , wherein the quotient is not greater than 2.5.25. The method according to claim 19 , wherein the base used in step (ii) is selected from the group consisting of aqueous sodium hydroxide solution claim 19 , aqueous potassium hydroxide ...

POLYESTER FIBER

An object of the present invention is to improve spinnability, productivity, and tensile strength of a polyester fiber containing poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). 1. A polyester fiber obtained by spinning a polyester resin comprising poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) at a spinning velocity of from 1 ,500 to 7 ,000 m/min ,{'sub': β', 'α', 'α', 'β', 'α', 'β', 'α', 'β, 'wherein the polyester fiber has a ratio I/Iof not less than 0.02, where Idenotes a diffraction intensity from α-crystals, Idenotes a diffraction intensity from β-crystals, and an influence on Iand Icaused by an amorphous phase in the polyester fiber is removed when measuring Iand I.'}2. The polyester fiber according to claim 1 , wherein the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) comprises 3-hydroxybutyrate as a monomer in an amount of from 99.5 to 88.5 mol %.3. The polyester fiber according to claim 1 , wherein the spinning of the polyester resin comprises extruding the polyester resin from a spinning die at a resin temperature of from 145 to 190° C.4. The polyester fiber according to claim 1 , wherein the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) has a weight-average molecular weight of from 150 claim 1 ,000 to 1 claim 1 ,500 claim 1 ,000.5. The polyester fiber according to claim 1 , wherein the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) has a weight-average molecular weight of from 200 claim 1 ,000 to 1 claim 1 ,000 claim 1 ,000.6. The polyester fiber according to claim 1 , wherein the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) comprises 3-hydroxybutyrate as a monomer in an amount of from 99 to 93 mol %.7. The polyester fiber according to claim 1 , wherein the polyester resin comprises not less than 70 wt% of the poly(3-hydroxybutyrate-co-3-hydroxyhexanoate).8. The polyester fiber according to claim 1 , wherein the polyester resin further comprises at least one of a lubricant and a plasticizer.9. A method for producing a polyester fiber claim 1 , comprising ...

PHOTOPOLYMERIZED BIODEGRADABLE COPOLYMER FORMULATIONS FOR BIOMEDICAL APPLICATIONS

A biodegradable based polymers for the production of biodegradable medical applications is provided. The biobased material has a copolymer constituted by dextran modified with glycidyl methacrylate and poly (#-caprolactone) modified with 2-isocyanatoethylmethacrylate, which are combined in different formulations and used to produce membranes, 3-D scaffolds and hollow tubes that can be used as biomedical devices for diverse applications such as drug delivery systems, tissue engineering scaffolds, repair and regeneration of peripheral nerves, among others. 1. A photopolymerized biodegradable copolymer formulations comprising dextran modified with glycidylmethacrylate and poly e-caprolactone modified with 2-isocyanatoethyl methacrylate.2. The copolymer formulations according to claim 1 , wherein the percentage of the modified dextran ranges between 25% and 50% (w/w).3. The copolymer formulations according to claim 1 , wherein the percentage of the modified poly e-caprolactone ranges between 50% and 75% (w/w).4. The copolymer formulations according to claim 1 , wherein the formulations further comprise water soluble sugar-type or salt-type known porogenic agents.5. The copolymer formulations according to claim 4 , wherein the porogenic agent is selected from the group consisting of sucrose claim 4 , sodium chloride and sodium carbonate.6. The copolymer formulations according to claim 4 , wherein the porogenic agent is D-mannitol.7. The copolymer formulations according to claim 6 , wherein the content of D-mannitol ranges between 20 and 80% (w/w) of the copolymer formulation.8. The copolymer formulations according to claim 1 , wherein the copolymer is shaped into films claim 1 , sheets claim 1 , tubes claim 1 , rods claim 1 , plugs claim 1 , microspheres claim 1 , 3-D scaffolds claim 1 , or meshes.9. The copolymer formulations according to claim 1 , wherein the copolymer formulations are solid.10. A method of photopolymerization to prepare solid materials from copolymer ...

Degradable polymer composition for use in downhole tools and method of manufacturing

A chemical composition for a degradable polymeric material includes an isocyanate terminated polyester prepolymer, including prepolymer units as a main chain with a plurality of isocynanates at ends of the main chain, and a cross-linking agent. The isocyanate terminated polyester prepolymer has a structural formula as follows:ONC—R″—NH—[—CO—R—R″′-]n-NH—R″—CNO,wherein R″′ is selected from a group consisting of —O— and —CO—O—R′—O—,wherein R, R′ and R″ are an aryl group or alkyl group and wherein n is a number of prepolymer units corresponding to length of the main chain. The composition degrades at a rate and at a delay depending on temperature and the composition for a component of a downhole tool. The composition has strength and elasticity for a component of a downhole tool.

Reduction sensitive biodegradable polyesteramides

The present invention relates to biodegradable polyesteramides (PEAs) comprising hydrophobic alpha-amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages. The present invention also relates to the use of the polyesteramides in medical applications such as cancer treatment, ophthalmic applications, therapeutic cardiovascular applications, veterinary applications, pain management applications, MSK applications and vaccine delivery compositions. The present invention also relates to a drug delivery composition comprising the PEA's and to a drug delivery system such as micro- or nanoparticles, micelles, liposomes, polymerosomes, micro- and nanogels, polymerosomes or nanotubes.

POLYMERS WITH ANTIMICROBIAL FUNCTIONALITIES

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality. 1. A method , comprising: 'a repeating ionene unit comprising a cation distributed along a degradable backbone, the degradable backbone comprising a terephthalamide structure, wherein the repeating ionene unit has antimicrobial functionality, and wherein the contacting the pathogen with the polymer electrostatically disrupts a membrane of the pathogen.', 'contacting the pathogen with a polymer, the polymer comprising2. The method of claim 1 , wherein the pathogen is selected from the group consisting of a Gram-negative microbe claim 1 , a Gram-positive microbe claim 1 , a fungi and yeast.3. The method of claim 1 , wherein the cation is selected from the group consisting of a nitrogen cation and a phosphorus cation.4. The method of claim 3 , wherein the cation is a nitrogen cation selected from the group consisting of a protonated secondary amine cation claim 3 , a protonated tertiary amine cation claim 3 , a quaternary ammonium cation and an imidazolium cation.5. The method of claim 1 , further comprising:attracting the polymer to a cell of the pathogen via an electrostatic interaction between the cation and a phospholipid bilayer membrane of the cell.6. The method of claim 5 , further comprising:destabilizing an integrity of the phospholipid bilayer membrane by inserting a hydrophobic functional group of the polymer into a hydrophobic region of the phospholipid bilayer membrane.7. The method of claim 5 , further comprising:cleaving a negatively charged portion of the phospholipid bilayer membrane by inserting a hydrophobic functional group of the ...

S-NITROSOTHIOL-MEDIATED HYPERBRANCHED POLYESTERS

The invention generally relates to compositions comprising degradable polymers and methods of making degradable polymers. Specifically, the disclosed degradable polymers comprise a biodegradable polymer backbone, a nitric oxide linker moiety, and a nitric oxide molecule. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. 1. A degradable polymer comprising:(a) a biodegradable polymer backbone;(b) at least one nitric oxide linker moiety pendant from the polymer backbone; and(c) at least one nitric oxide molecule covalently bonded to the nitric oxide linker moiety.2. The polymer of claim 1 , wherein the degradable polymer is hyperbranched.3. The polymer of claim 1 , wherein the polymer backbone is a polyester backbone.12. The polymer of claim 1 , wherein the nitric oxide linker moiety and nitric oxide together comprise a nitrosothiol.13. A pharmaceutical composition comprising a therapeutically effective amount of at least one degradable polymer of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , and a pharmaceutically acceptable carrier.14. A polymer comprising:(a) a biodegradable polymer backbone; and(b) at least one nitric oxide linker moiety pendant from the polymer backbone.15. The polymer of claim 14 , wherein the polymer backbone is a polyester backbone.16. The polymer of claim 14 , wherein the nitric oxide linker moiety comprises a dithiol.18. A method for the treatment of a disorder in a subject claim 14 , the method comprising the step of administering to the subject an effective amount of a degradable polymer comprising:(a) a biodegradable polymer backbone;(b) at least one nitric oxide linker moiety pendant from the polymer backbone; and(c) at least one nitric oxide molecule covalently bonded to the nitric oxide linker moiety.19. The method of claim 18 , wherein the disorder is selected from cancer claim 18 , a cardiovascular disease claim ...

DEGRADABLE MICROPARTICLE, DEGRADABLE PRODUCT COMPRISING THE SAME AND APPLICATION THEREOF

Provided is a degradable microparticle with a grain size in a range of 2 micrometers to 1400 micrometers, and the degradable microparticle comprises poly(glycerol sebacate), poly(glycerol maleate), poly(glycerol succinate-co-maleate), poly(glycerol succinate), poly(glycerol malonate), poly(glycerol glutarate), poly(glycerol adipate), poly(glycerol pimelate), poly(glycerol suberate), poly(glycerol azelate), or any combination thereof. A degradable product produced from the degradable microparticles can obtain the desired degradation effect and can be produced by chemical synthesis to reduce the production cost. With these advantages, the applicability of the degradable microparticles is improved. 1. A degradable microparticle , wherein a material of the degradable microparticle comprises poly(glycerol sebacate) , poly(glycerol maleate) , poly(glycerol succinate-co-maleate) , poly(glycerol succinate) , poly(glycerol malonate) , poly(glycerol glutarate) , poly(glycerol adipate) , poly(glycerol pimelate) , poly(glycerol suberate) , poly(glycerol azelate) , or any combination thereof; a grain size of the degradable microparticle is in a range of 2 micrometers to 1400 micrometers.2. The degradable microparticle as claimed in claim 1 , wherein a polydispersity index of the grain size of the degradable microparticle is in a range of 0.15 to 1.2.3. The degradable microparticle as claimed in claim 1 , wherein a shape of the degradable microparticle is spherical claim 1 , water drop shaped claim 1 , threaded claim 1 , square claim 1 , polyhedral claim 1 , or any combination thereof.4. The degradable microparticle as claimed in claim 1 , wherein a structure of the degradable microparticle is a solid structure claim 1 , a hollow structure claim 1 , a porous structure claim 1 , or any combination thereof.5. A use of the degradable microparticle as claimed in claim 1 , which comprises preparing a degradable product from the degradable microparticle.6. The use of the degradable ...

A HYDROPHILIC POLYESTER AND A BLOCK COPOLYMER THEREOF

The invention belongs to the field of macromolecules and biomedical materials, and relates to a polymer, a block copolymer comprising the polymer as a segment, methods for preparing the polymer and for preparing the block copolymer, a micelle particle or a vesicle particle prepared from the block copolymer, and a composition comprising the polymer, the block copolymer, the micelle particle and/or the vesicle particle. The polymer provided in the invention can be used as a novel biomedical material in in the fields such as pharmaceutical formulations, immunological formulations, and gene delivery reagents. 4. (canceled)5. A block polymer , comprising a segment consisting of the repeat units of Formula (I)6. A method for preparing the block copolymer according to claim 5 , comprising the step of using a polymer having a structure of Formula (II) to initiate a polymerization reaction of a second monomer.7. A micelle particle claim 5 , comprising the block copolymer according to .8. A vesicle particle claim 5 , comprising the block copolymer according to .9. A pharmaceutical composition claim 5 , comprising the polymer according to claim 5 , a block polymer comprising a segment consisting of the repeat units of Formula (I) in claim 5 , a micelle particle comprising the block polymer and/or a vesicle particle comprising the block polymer claim 5 , and a drug.10. A composition claim 5 , comprising the polymer according to claim 5 , a block polymer comprising a segment consisting of the repeat units of Formula (I) in claim 5 , a micelle particle comprising the block copolymer and/or a vesicle particle comprising the block copolymer.12. A polymer claim 5 , prepared by using a compound having a structure of Formula (III) as a monomer.14. The polymer according to claim 1 , wherein the polymer has one or more features selected from:(1) the polymer is a homopolymer;(2) the polymer has a number-average molecular eight of 400-300000;(3) m=3; and(4) n=3.16. The micelle particle ...

RESORBABLE, AMINO ACID-BASED POLY(ESTER UREA)S SCAFFOLD FOR VASCULAR GRAFT TISSUE ENGINEERING

Embodiments relate to amino acid-based poly(ester urea)s with amino acid residues selected L-leucine, L-isoleucine, L-valine or combinations thereof. The amino acid-based poly(ester urea)S may optionally include a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids. The amino acid-based poly(ester urea)s are particular useful for the preparation of vascular grafts. Due to the biocompatibility of the amino acid-based poly(ester urea)s, vascular grafts prepared from amino acid-based poly(ester urea)s with small internal diameters (i.e. less than 5 mm) may be prepared and inserted into a patient or animal, and provide a substantial decrease in the risk of failure compared to conventional polymers used in vascular grafts. 1. An amino acid-based poly(ester urea) comprisingan amino acid residue selected from L-leucine, L-isoleucine, L-valine or combinations thereof; anda hydrocarbylene group having from 10 to 12 carbon atoms;where the hydrocarbylene group is attached to the amino acid residue through an ester group.2. The amino acid-based poly(ester urea) of claim 1 , where the amino acid-based poly(ester urea) further includes a second amino acid residue selected from proteinogenic amino acids and non-proteinogenic amino acids.4. The amino acid-based poly(ester urea) of claim 3 , where the pendent functional group is an oxygen atom connected to a alkyl or aryl group containing an alkyne group claim 3 , an alkene group claim 3 , an azide group claim 3 , a benzyl protected phenol group claim 3 , a ketone group or a strained cyclooctyne.6. (canceled)13. An amino acid-based poly(ester urea) vascular graft comprising a tubular structure comprising an amino acid-based poly(ester urea) with amino acid residues selected from L-leucine claim 3 , L-isoleucine claim 3 , L-Valine or combinations thereof.16. The poly(ester urea) vascular graft of claim 13 , where the poly(ester urea) is electrospun.17. The poly(ester urea) vascular ...

Degradable downhole tools comprising thiol-based polymers

A degradable downhole tool or component thereof comprising a thiol-based polymer having at least one thiol functional group, wherein the thiol-based polymer is capable of at least partially degrading in a wellbore environment, thereby at least partially degrading the downhole tool or component thereof. The thiol-based polymer may be selected from the group consisting of a thiol-ene, a thiol-yne, a thiol-epoxy, and any combination thereof.

POLYURETHANES FOR OSTEOIMPLANTS

Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant. 1. A biodegradable polyurethane composite , comprising: a polyurethane matrix formed by reaction of a polyisocyanate with a hydroxylated biomolecule to form a biodegradable polyurethane polymer; and a reinforcement embedded in the matrix , wherein the reinforcement comprises bone and bone substitutes.231-. (canceled)32. A biodegradable polyurethane , formed by reaction of a polyisocyanate with a mixture of hydroxylated biomolecules to form a polyurethane polymer , wherein the mixture of hydroxylated biomolecules comprises polysaccharides; and lipids or phospholipids.33. The polyurethane of claim 32 , wherein the polymer is cross-linked.34. The polyurethane of claim 32 , wherein the polyisocyanate is a diisocyanate.35. The polyurethane of claim 32 , wherein the polyisocyanate is selected from the group consisting of lysine diisocyanate claim 32 , toluene diisocyanate claim 32 , arginine diisocyanate claim 32 , asparagine diisocyanate claim 32 , glutamine diisocyanate claim 32 , hexamethylene diisocyanate claim 32 , hexane diisocyanate claim 32 , methylene bis-p-phenyl diisocyanate claim 32 , isocyanurate polyisocyanates claim 32 , 1 claim 32 ,4-butane diisocyanate claim 32 , uretdione polyisocyanate claim 32 , and aliphatic claim 32 , alicyclic claim 32 , and aromatic polyisocyanates.36. The polyurethane of claim 32 , wherein the mixture of biomolecule comprises lecithin.37. The polyurethane of claim 32 , further comprising polycaprolactone.38. The polyurethane of claim 32 , further comprising a substance selected from a biomolecule claim 32 , a bioactive agent claim 32 , and a small molecule.39. The polyurethane ...

Ethylene oxide-based copolymers

Degradable ethylene oxide-based copolymers, including random, tapering, and block copolymers are described. For example, the present disclosure describes materials and methods for synthesizing degradable hydrophilic ethylene oxide-based copolymers, degradable amphiphilic ethylene oxide-based block copolymers, degradable hydrophobic polyethers and degradable functionalized polyethers via boron-activated copolymerization of ethylene oxide monomers with carbon dioxide.

BLACK POLYESTER FILM AND METHOD FOR MANUFACTURING THE SAME

A black polyester film and a method for manufacturing the same are provided. The black polyester film includes a physically recycled polyester resin and a chemically recycled polyester resin. The physically recycled polyester resin is formed by a plurality of physically recycled polyester chips. 1. A method for manufacturing a black polyester film , which is used to recycle and reuse a recycled polyester material , the method comprising:physically reproducing a part of the recycled polyester material and granulating the same to obtain a plurality of physically recycled polyester chips;chemically reproducing another part of the recycled polyester material and granulating the same to obtain a plurality of chemically recycled polyester chips, wherein the plurality of chemically recycled polyester chips further include chemically recycled electrostatic pinning polyester chips, and wherein the chemically recycled electrostatic pinning polyester chips contain at least one kind of electrostatic pinning additives, and the electrostatic pinning additives are metal salts; andmixing the plurality of physically recycled polyester chips and the plurality of chemically recycled polyester chips, and melt extruding the same to form a polyester film;wherein, based on 100 parts by weight of a total content of the polyester chips, a content of the chemically recycled electrostatic pinning polyester chips of the plurality of chemically recycled polyester chips is between 5 and 35 parts by weight;wherein the method further comprises: in the physical reproducing step, adding a black additive to the recycled polyester material, so that the polyester film that is finally formed includes the black additive.2. The method according to claim 1 , wherein the black additive is at least one selected from a material group consisting of carbon black powder claim 1 , graphite powder claim 1 , nano carbon black claim 1 , carbon nanotube claim 1 , and graphene; wherein a particle size of the black ...

Tissue-Adhesive Biomedical Materials

The invention is directed to a biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment, wherein at least one of said polyurethane segment comprises a tissue-reactive functional group. A further aspect of the invention is directed to biodegradable tissue-adhesive medical devices, based on the polyurethane polymer, having the structure of a sheet, foam, stent, tube or gel. The polyurethane polymer and the device can be used in medical application. 114.-. (canceled)15. Biodegradable tissue-adhesive polyurethane polymer comprising at least one amorphous segment and at least one polyurethane segment , wherein at least one of said polyurethane segment comprises a tissue-reactive functional group , wherein the tissue-reactive functional group is an activated ester , an acid chloride , an anhydride , p-nitrophenyl carbonate , an epoxide , an isocyanate , a vinyl sulfone , maleimide , o-pyridyl-disulfide , a thiol or combinations thereof.2. Biodegradable tissue-adhesive polyurethane polymer according to the previous claim , wherein the activated ester is selected from the group consisting of a thioester , a perfluoroalkyl ester , a pentafluorophenol ester , a N-hydroxysuccinimide ester and derivatives thereof.4. Biodegradable tissue-adhesive polyurethane polymer according to the previous claim , wherein the functionalized chain extender (R) and the chain extender (R) independently comprise a C-Calkylene or alkyl , a (poly)urethane group , a (poly)ester , a (poly)lactide or a (poly)ether , preferably a C-Calkylene or alkyl , and wherein , the tissue-reactive functional group (R) is substituted with a C-Chydrocarbon comprising the tissue-reactive functional group.619. Method for the preparation of a pre-functionalized biodegradable polyurethane polymer according to claim , said method comprising chain extending a pre-polymer with a chain extender substituted with a pre-reactive functional group and ...

ALTERNATING BLOCK POLYURETHANES AND THE USE IN NERVE GUIDANCE CONDUITS

This invention of new biomaterials of alternating block polyurethanes (AltPU) based on biodegradable polyester blocks and hydrophilic blocks such as polyethers are created through a selectively coupling reaction between aliphatic polyester diols and diisocyanate-terminated hydrophilic polyethers or between aliphatic polyester diols and diisocyanate-terminated aliphatic polyester blocks under catalysis of organic tin compounds. AltPU possess well-controlled and defined chemical structures as well as regular polymer chain architecture and surface microstructures. The alternating block polyurethane designs endow materials with more special and intriguing properties, such as better biocompatibility, higher hydrophilicity, and favorable mechanical and material processing properties. Medical devices made of AltPU biomaterials show outstanding performance in peripheral nerve repair. In peripheral nerve repair (NGC), NGCs made of AltPU exhibit even better repair results than autograft, without adding any additional growth factors or proteins on SD rat model. The NGCs can also contain bioactive substances. The AltPU biomaterials can be widely used for many medical and non-medical applications including but not limited to tissue regeneration of soft and hard tissues, medical tubings and catheters, device coatings, and other applications. 16-. (canceled)7. A medical device formed from the block copolymer with alternating arrangement of the block segments , but also including random arrangement of the block segments. The biodegradable block polyurethanes comprise first blocks and second blocks; and wherein first blocks and second blocks are linked via urethane bonds. The first blocks comprise a diol-terminated aliphatic polyester , and the second blocks comprise a two diisocyanate-terminated hydrophilic polymer or oligomer81. A medical device of claim , wherein the medical device is a peripheral nerve guidance conduit. The peripheral nerve guidance is formed from the ...

POLYMER PRODUCT AND PRODUCTION METHOD THEREOF, AND MOLDED PRODUCT

Provided is a polymer product having a branched chain made of polyester, and a weight average molecular weight of 200,000 or greater when measured by gel permeation chromatography. 1. A polymer product , comprising:a branched chain made of polyester,wherein the polymer product has a weight average molecular weight of 200,000 or greater when measured by gel permeation chromatography.2. The polymer product according to claim 1 , wherein the polymer product has an average branching degree of 2.1 or greater.3. The polymer product according to claim 1 , wherein a raw material monomer of the polymer product is a ring-opening-polymerizable cyclic ester.4. The polymer product according to claim 1 , wherein the polymer product is obtained by ring-opening-polymerizing a ring-opening-polymerizable cyclic ester using a polyhydric alcohol as an initiator.5. The polymer product according to claim 1 , wherein the polymer product has a residual monomer content of 5 claim 1 ,000 ppm or less.6. The polymer product according to claim 1 , wherein the polymer product has a weight average molecular weight of 300 claim 1 ,000 or greater when measured by gel permeation chromatography.7: A molded product claim 1 , wherein the molded product is obtained by molding the polymer product according to .8: The molded product according to claim 7 , wherein the molded product is any of particles claim 7 , a film claim 7 , a sheet claim 7 , a molded article claim 7 , and a fiber.9. A method for producing the polymer product according to claim 1 , comprising:bringing a multifunctional initiator, a ring-opening-polymerizable monomer, and a compressive fluid into contact with one another to ring-opening-polymerize the ring-opening-polymerizable monomer.10. The method for producing the polymer product according to claim 9 , wherein the compressive fluid comprises carbon dioxide. The present invention relates to a polymer product and a polymer product production method, and a molded product.General- ...

CROSS-LINKED RADIOPAQUE BIORESORBABLE POLYMERS AND DEVICES MADE THEREFROM

The present application provides polymer materials having the desired properties for implantation into a human or animal body, in particular, biocompatibility, biodegradability, radiopacity and mechanical properties. Methods of making such polymer materials, compositions or devices comprising such polymer materials, and uses of such polymer materials, compositions and devices are also disclosed. 1. A polymer material , comprising one or more of polymers , homogeneous polymers , copolymers , block co-polymers , and/or blends or mixtures thereof;wherein the biocompatible polymer material is optionally inherently radiopaque, and/or bioresorbable;wherein the polymer material comprises at least one polymer component which, as initially prepared, has a latently cross-linkable state, such that it comprises functional groups which are configured to react upon being subjected to at least one cross-linking initiation treatment to crosslink the polymer;wherein the polymer material comprises at least one polymer component which, as initially prepared, has a rubbery or partially rubber state at a temperature less than 37° C.;wherein the polymer material, prior to being subjected to the at least one cross-linking initiation treatment, has properties allowing it to be formed into a selected structural shape without initiating cross-linking; andwherein the polymer material, after subjected to at least one cross-linking initiation treatment, has a cross-linked state, such that it has a sufficient number and/or density of cross-links between polymer chains within the material so as to enhance the material properties to create a strong, tough, resilient material, such that a selected shape composed of the cross-linked polymer material has crush-recoverable properties allowing substantial return to the selected shape following mechanical deformation.2. The polymer material of claim 1 , wherein the material is in a latently cross-linkable state claim 1 , the material not having been ...

CONTROLLED RELEASE OF WATER-SOLUBLE AGENTS

A method of controlled release includes exposing a polymeric composition to an aqueous liquid to permit surface erosion of a polymeric material of the polymeric composition, thereby controllably releasing the at least one water-soluble agent. The polymeric composition includes the polymeric material and the at least one water-soluble agent homogenously mixed with the polymeric material. The polymeric material includes a polyester copolymer of an alcohol monomer and an acid monomer. A method of preparing a polymeric composition includes forming a polymeric material from an alcohol monomer and an acid monomer in the presence of at least one water-soluble agent. 1. A method of controlled release of at least one water-soluble agent , the method comprising:exposing a polymeric composition to an aqueous liquid to permit surface erosion of a polymeric material of the polymeric composition, thereby controllably releasing the at least one water-soluble agent;wherein the polymeric composition comprises the polymeric material and the at least one water-soluble agent homogenously mixed with the polymeric material; andwherein the polymeric material comprises a polyester copolymer of an alcohol monomer and an acid monomer.2. The method of claim 1 , wherein the water-soluble agent is selected from the group consisting of a vitamin claim 1 , an anti-inflammatory agent claim 1 , a protein claim 1 , a protease claim 1 , an herbicide claim 1 , an aquarium food source claim 1 , a growth factor claim 1 , a glycoprotein claim 1 , a proteoglycan claim 1 , an anti-mitotic agent claim 1 , an antiplatelet agent claim 1 , an anti-coagulant agent claim 1 , an anti-thrombotic agent claim 1 , a thrombolytic agent claim 1 , an enzyme claim 1 , a chemotherapeutic agent claim 1 , an antibiotic agent claim 1 , an immunological adjuvant claim 1 , a natural product claim 1 , a scaffolding material claim 1 , a processing agent claim 1 , and combinations thereof.3. The method of claim 1 , wherein the ...