Поиск патентов

Настройки

Глубина выборки

Укажите год

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Ключевые слова. Может быть несколько по одной на строку

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка

Автор

Ведите корректный номера.

Владелец

Ведите корректный номера.

Классы IPC

Ведите корректный номера.

Классы CPC

Ведите корректный номера.

Начиная с года

Укажите год

Заканчивая годом

Укажите год

Применить Всего найдено 19492. Отображено 100.

05-01-2012 дата публикации

Intermediates Useful in the Preparation of Maleimide Functionalized Polymers

Номер: US20120004422A1

Автор: Antoni Kozlowski, Brian Bray, Samuel P. McManus, Tracy L. Hutchison, Xiaoming Shen

Принадлежит: Nektar Therapeutics

Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

Подробнее

Номер записи: 1

26-01-2012 дата публикации

Natural oil polyols in elastomers for tires

Номер: US20120018066A1

Автор: Kandathil E. Verghese, Rui Xie, Syed A. Shah

Принадлежит: Dow Global Technologies LLC

Prepolymers having active NCO groups are disclosed. The prepolymers are the reaction product of at least one polyisocyanate and a polyhydric component which comprises at least one dimer fatty derivative diol or diamine that is a natural oil based polyol or polyamine which includes the derivative of at least one dimer fatty acid. Polyurethane and polyurea elastomer obtained from the prepolymers are also disclosed. Also disclosed are methods of manufacturing polyurethane or polyurea treaded tires.

Подробнее

Номер записи: 2

16-02-2012 дата публикации

Surfactants in Agrochemical Formulations

Номер: US20120040834A1

Автор: Gregory James LINDNER, Lee David Richards, Trevor Graham Blease

Принадлежит: Croda Inc, Croda International PLC

Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C 22 to C 60 mainly hydrocarbyl, particularly composite hydrocarbyl, especially derived from a polymerised fatty acid and/or an aralkyl substituted phenol, hydrophobe, are useful in dispersing solids, particularly active agrochemicals, in aqueous media, or as adjuvants in agrochemical formulations, particularly of water soluble non-selective herbicides. In particular the hydrophobe is derived from polymerised fatty acids, such as dimer and, especially, trimer acids or from aralkyl substituted phenols. Aqueous dispersions using such surfactants can remain stable even with substantial concentrations of electrolyte e.g. in stable agrochemical dispersions including water soluble electrolyte agrochemical, such as glyphosate and/or ammonium sulphate.

Подробнее

Номер записи: 3

08-03-2012 дата публикации

Process for the purification of polyol PFPE derivatives

Номер: US20120055779A1

Автор: Claudio Adolfo Pietro Tonelli, Fabrizio Mutta, Graziano Giuseppe Vezzulli, Piero Gavezotti

Принадлежит: Solvay Solexis SpA

A process for purifying a polyol (per)fluoropolyether derivative [polyol (P)] from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)]. Such polyol (P) comprising one or more hydroxyl (per)fluoropolyether derivatives [PFPE (OH)] comprising at least one (per)fluoropolyoxyalkylene chain (chain R f ) and at least one end-group having formula (t 3 )-CF 2 CH 2 OCH 2 CH(OH)CH 2 OCH 2 CH(OH)CH 2 OH. Such mixture (M) comprising the polyol (P) and at least one PFPE (OH) different from the polyol (P) and comprising at least one chain R f and at least one end-group selected from end-groups having formula (t 1 )-CF 2 CH 2 OH and formula (t 2 )-CF 2 CH 2 OCH 2 CH(OH)CH 2 OH. The process comprises the steps of: 1) reacting the mixture (M) with a ketone, an aldehyde or a combination thereof to yield corresponding mixture of cyclic ketal/acetal (per)fluoropolyether derivatives [PFPEs (OH) p ] [protected mixture (P)]; 2) carrying out a molecular distillation of the protected mixture (P) to isolate a protected product heavy residue [product (P r )]; 3) hydrolyzing the product (P r ) to yield deprotected product [product (P d ]); and 4) carrying out a distillation under reduced pressure of the product (P d ) to obtain polyol (P).

Подробнее

Номер записи: 4

08-03-2012 дата публикации

Novel Copolymers for Use as Oilfield Demulsifiers

Номер: US20120059088A1

Автор: Christine Ann Blundell, Darryl M. Stepien, Matthew Hilfiger, Michael P. Squicciarini, Patrick J. Breen

Принадлежит: Baker Hughes Inc

Lactone/alkylene oxide polymers are useful as demulsifiers to break emulsions, e.g. water-in-oil and oil-in-water emulsions, particularly oilfield emulsions. These polymers are random or block polymer made from addition reactions of a hydroxyl- and/or amine-containing base compound with at least one lactone monomer and at least one alkylene oxide monomer.

Подробнее

Номер записи: 5

19-04-2012 дата публикации

Molecularly Imprinted Polymers for Use as Imaging and Therapeutics Agents

Номер: US20120093720A1

Автор: Robert Jones, Thomas Beck

Принадлежит: Individual

The invention described herein provides biocompatible molecularly imprinted polymers (MIPs) that are non-toxic, water soluble, small molecular weight, and degradable in a living body. The MIPs are capable of binding to all or a portion of a specific target macromolecule associated with a disease located within the living body and they are derivatized for stealth for in vivo applications to avoid the reticuloendothelial system. The MIPs of the invention are functionalized to an amine or carboxyl group and are derivatized with an imaging and/or therapeutic agent for taking images of the disease and/or for providing therapy. The macromolecule can be selected from a group consisting of proteins, glycoproteins, lipoproteins, peptidoglycans, peptides, polypeptides, polynucleotides, and polysaccharides. The invention described herein also provides methods and kits wherein MIPs of the invention can be employed as targeted imaging and therapeutic agents.

Подробнее

Номер записи: 6

10-05-2012 дата публикации

Polymer Conjugates with Decreased Antigenicity, Methods of Preparation and Uses Thereof

Номер: US20120114742A1

Автор: Alexa L. Martinez, L. David Williams, Mark G.P. Saifer, Merry R. Sherman

Принадлежит: Mountain View Pharmaceuticals Inc

Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.

Подробнее

Номер записи: 7

24-05-2012 дата публикации

Process for the preparation of polyetherols from alkylene oxides

Номер: US20120130134A1

Автор: Achim Loeffler, Dirk Meckelnburg, Eckard Schauss, Hans Volkmar Schwarz, Hans-Juergen Pallasch, Matthias Schopohl, Renata Jovanovic, Susanne Szeschkus, Thomas Ostrowski, Thorsten Friese, Vinit Chilekar

Принадлежит: BASF SE

A process for the preparation of polyetherols, comprising the following steps: a) reaction of at least one starter compound with at least one alkylene oxide and a catalyst to give a crude polyetherol and b) removal of low molecular weight byproducts from the crude polyetherol from step a), wherein the crude polyetherol is treated with a stripping gas in a column having internals.

Подробнее

Номер записи: 8

07-06-2012 дата публикации

Charging member, process cartridge and electrophotographic apparatus

Номер: US20120141159A1

Автор: Noriaki Kuroda, Noriko Nagamine, Yuya Tomomizu

Принадлежит: Canon Inc

A charging member is provided with a surface layer that can not easily wear even due to its contact with a photosensitive member and also has an appropriate elasticity contributing to the formation of an appropriate nip between it and the photosensitive member. The charging member has a substrate, an elastic layer and a surface layer; the surface layer containing a high-molecular compound having an Si—O—Hf linkage and having a constitutional unit represented by the formula (1) and a constitutional unit represented by the formula (2):

Подробнее

Номер записи: 9

28-06-2012 дата публикации

Glue for repair or attachment free of organotin

Номер: US20120165453A1

Автор: Jacqueline Carrard, Virginie Cagan

Принадлежит: BOSTIK SA

The invention relates to an adhesive composition, including: 10 to 95% of a moisture cross-linkable polymer (A), the main chain includes 2 silyl terminal groupings, each of which includes at least one hydrolyzable group bonded to the silicon atom; 1 to 60% of a mineral filler (B) in the form of particles having a size of between 1 nm and 0.2 mm; and 0.2 to 7% of a cross-linking catalyst (C) consisting of titanium tetraisopropoxide. The invention also relates to the use of said composition as glue for repair or attachment.

Подробнее

Номер записи: 10

28-06-2012 дата публикации

Isocyanate-free silane-crosslinking compounds

Номер: US20120165493A1

Автор: Andreas Bauer, Bernd-Josef Bachmeier, Volker Stanjek

Принадлежит: Wacker Chemie AG

The invention relates to compounds (K) comprising A) 100 parts by weight of a pre-polymer (P) comprising units (E) in the backbone thereof that are selected from polyether and polyester units, wherein the pre-polymer (P) comprises at least one end group of the general formula (1) -L 1 -(CH 2 ) y —SiR 2 3-x (OR 1 ) x (1), B) 1 to 100 parts by weight of silane (S) of the general formula (2) R 4 SiR 2 3-Z (OR 1 ) z (2), (G) 0 to 10 parts by weight of a curing catalyst (HK) that accelerates the curing of the compounds (K) in the presence of humidity, wherein L 1 represents a divalent linking group selected from —O—, —S—, —(R 3 )N—, —O—CO—N(R 3 )—, —N(R 3 )—CO—O—, —N(R 3 )—CO—NH—, —NH—CO—N(R 3 )—, —N(R 3 )—CO—N(R 3 ) and R 1 , R 2 , R 3 , x, y and z have the meanings cited in claim 1. R 4 are hydrocarbon radicals having at least 7 hydrogen atoms. According to the invention, after hardening, the compounds (K) have high shear strength and are used as adhesives (K).

Подробнее

Номер записи: 11

12-07-2012 дата публикации

Reactive diluents containing silane groups

Номер: US20120175563A1

Автор: Axel Schmidt, Frank Kobelka, Jorg Hofmann, Klaus Lorenz, Mathias Matner, Michael Ludewig

Принадлежит: BAYER MATERIALSCIENCE AG

The present invention relates to reactive diluents for moisture-curing coating systems containing silane groups. The invention further relates to a method for the production of said diluents, and to the use thereof in coating agents, adhesives and sealants.

Подробнее

Номер записи: 12

19-07-2012 дата публикации

Process for preparing a polymer polyol

Номер: US20120184707A1

Автор: Andre Buijs, Nico Maria Venne, Paulus Jacobus Fennis, Willem Karzijn

Принадлежит: Shell Internationale Research Maatschappij BV

The invention relates to a process for preparing a polymer polyol, comprising mixing in a reactor vessel, a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200° C., wherein after discharging the reactor vessel content, the interior surface of the reactor vessel walls and/or any internals present in the reactor vessel are blasted with round media.

Подробнее

Номер записи: 13

02-08-2012 дата публикации

Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom

Номер: US20120195846A1

Автор: J. Milton Harris, Xuan Zhao

Принадлежит: Nektar Therapeutics AL Corp

A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

Подробнее

Номер записи: 14

06-09-2012 дата публикации

Branched poly(trimethylene ether) polyols

Номер: US20120225964A1

Автор: Gyorgyi Fenyvesi, Hari Babu Sunkara, Raja Hari Poladi

Принадлежит: EI Du Pont de Nemours and Co

Disclosed is branched poly(trimethylene ether)polyols prepared from the acid catalyzed polycondensation reaction of 1,3-propanediol, and at least one triol comonomer selected from 1,1,1-tris(hydroxymethyl)ethane and 1,1,1-tris(hydroxymethyl)propane. Also disclosed is a branched poly(trimethylene ether)polyol with an equivalent hydroxyl functionality of about 2.1 to about 3.2 and a M n of about 200 to about 6000. The polyols are useful in the preparation of polyurethane rigid and flexible foams.

Подробнее

Номер записи: 15

20-09-2012 дата публикации

Amine adducts

Номер: US20120238710A1

Автор: Ludwig Huelskaemper, Marcus Hummel, Markus Schroetz

Принадлежит: Individual

Embodiments include an amine adduct obtainable by reacting an amine compound having at least two amino groups and a monoalkylpolyalkylene glycidyl ether having the formula (C 2 H 3 O)—CH 2 —O—(CH 2 —(CHR 1 )—O) n , —R 2 , wherein n is 1 to 50, each R 1 is independently H or CH 3 , and R 2 is an alkyl group. Embodiments include a curable composition including a resin component and a hardener component that includes the amine adduct.

Подробнее

Номер записи: 16

27-09-2012 дата публикации

Defoamers for airless paint spray application

Номер: US20120240820A1

Автор: Armin TEMEL, Gerald Hobisch, Joachim Schmidt, Peter Morre, Thomas Schönbacher

Принадлежит: Cytec Austria GmbH

The invention relates to an ester AB of a polypropylene glycol A with fatty acids B, which ester AB can be added in the form of an aqueous emulsion to an aqueous coating composition, and a method of use of the ester AB as defoamer additive.

Подробнее

Номер записи: 17

04-10-2012 дата публикации

Antimicrobial constructs

Номер: US20120251592A1

Автор: Jennifer A. Neff, Joseph Mcguire, Pranav R. Joshi

Принадлежит: ALLVIVO VASCULAR Inc, Oregon State University

The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.

Подробнее

Номер записи: 18

04-10-2012 дата публикации

Moisture Curable Silylated Polymer Compositions With Improved Adhesion to Concrete

Номер: US20120251832A1

Автор: Jeries Nesheiwat, Misty Huang

Принадлежит: Momentive Performance Materials Inc

A moisture-curable resin composition comprising (a) at least one moisture-curable polymer having at least one hydrolysable silyl group; (b) at least one hydrocarbylalkoxysilane; and (c) at least one silane adhesion promoter containing a glycidoxy group. The composition may also contain additives including a catalyst for catalyzing the reaction between the moisture-curable polymer having at least one hydrolysable silyl group (a) with water under curing conditions, a filler, a plasticizer, and combinations thereof. The moisture-curable resin composition is useful in the production of adhesives, sealants and coatings for use in primerless concrete applications.

Подробнее

Номер записи: 19

15-11-2012 дата публикации

Perfluoropolyether-containing compounds with oxalylamino groups

Номер: US20120289736A1

Автор: David S. Hays, George G.I. Moore, Miguel A. Guerra, Ramesh C. Kumar, Richard G. Hansen, Suresh S. Iyer, Yu Yang

Принадлежит: 3M Innovative Properties Co

Compounds containing at least one perfluoropolyether segment and at least two oxalylamino groups as well as methods of making these compounds are described. The compounds can be polymeric materials or can be used in the preparation of various copolymeric materials by reaction with compounds having at least two primary or secondary amino groups.

Подробнее

Номер записи: 20

29-11-2012 дата публикации

Intermediates useful in the preparation of maleimide functionalized polymers

Номер: US20120302761A1

Автор: Antoni Kozlowski, Brian Bray, Samuel P. McManus, Tracy L. Hutchison, Xiaoming Shen

Принадлежит: Nektar Therapeutics

Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

Подробнее

Номер записи: 21

06-12-2012 дата публикации

New polyglycerol esters and their use

Номер: US20120309667A1

Автор: Hans Henning Wenk, Peter Lersch, Ulrike Kottke

Принадлежит: EVONIK GOLDSCHMIDT GMBH

The present invention relates to polyglycerol partial esters of linear, unsubstituted carboxylic acids and bifunctional carboxylic acids with the provisos that the polyglycerol partial ester comprises an HLB-value from 2 to 10 and that the polyglycerol obtained by hydrolysis or alcoholysis of the polyglycerol partial ester comprises an average degree of polymerization of from 2 to 8 and at least 1% of the polyglycerol comprises cyclic structures. The present invention also relates to the preparation thereof and their use in fabric and textile care products.

Подробнее

Номер записи: 22

20-12-2012 дата публикации

Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom

Номер: US20120318701A1

Автор: Samuel P. McManus, Sean M. Culbertson

Принадлежит: Nektar Therapeutics

The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

Подробнее

Номер записи: 23

20-12-2012 дата публикации

Branched polymers

Номер: US20120322134A1

Автор: Michael David Bentley, William Dudley Battle, Iii, Xiaoming Shen, Xuan Zhao

Принадлежит: Nektar Therapeutics

The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through ether linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-) m , or (-alkylene-O—) m linkage, wherein m is 1-10.

Подробнее

Номер записи: 24

20-12-2012 дата публикации

Modified recombinant factor viii and von willebrand factor and methods of use

Номер: US20120322737A1

Автор: Hans-Peter Schwarz, Peter Turecek

Принадлежит: Baxter Healthcare SA, Baxter International Inc

The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.

Подробнее

Номер записи: 25

10-01-2013 дата публикации

Active energy ray-curable resin composition, and production method for products with surfaces of fine concave-convex structures

Номер: US20130011572A1

Автор: Eiko Okamoto, Satoru Ozawa, Tadashi Nakamura, Tetsuya Jigami, Yusuke Nakai

Принадлежит: Mitsubishi Rayon Co Ltd

The present invention relates to a production method for a product having a cured resin layer with a fine concave-convex structure formed on the surface of a substrate, the method including filling the space between a mold having a fine concave-convex structure composed of anodized alumina on the surface and a substrate with an active energy ray-curable resin composition, and curing the composition by irradiation with active energy rays, thereby forming a cured resin layer into which the fine concave-convex structure has been transferred on the surface of the substrate, wherein (A) the method includes treating the surface of the mold with a release agent, at least at transfer initiation, and (B) the active energy ray-curable resin composition includes a polymerizable compound, a polymerization initiator and a (poly)oxyethylene alkyl phosphate ester compound.

Подробнее

Номер записи: 26

24-01-2013 дата публикации

Novel compounds

Номер: US20130022560A1

Автор: Alexander Schlifkeposchalko

Принадлежит: DSM IP ASSETS BV

The invention relates to novel polyglycerol based UV-filters as well as to topical compositions comprising such novel polyglycerol based UV-filters. Furthermore, the invention relates to the use of such novel polyglycerol based UV-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils.

Подробнее

Номер записи: 27

14-02-2013 дата публикации

Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material

Номер: US20130041134A1

Автор: John R. Handley, Jonathon B. McKannan

Принадлежит: Sangart Inc

The present invention relates generally to methods for preparing polyethylene glycol maleimide (“PEG-Mal”). More specifically, the present invention relates to methods for synthesizing desired molecular weight PEG-Mal by direct ethoxylation of N-(2-hydroxyethyl)maleimide under specific reaction conditions.

Подробнее

Номер записи: 28

14-03-2013 дата публикации

Coatings Containing Polymer Modified Enzyme For Stable Self-Cleaning Of Organic Stains

Номер: US20130065291A1

Автор: Andreas Buthe, Hongfei Jia, Liting Zhang, Masahiko Ishii, Minjuan Zhang, PING Wang, Songtao Wu, Xueyan Zhao

Принадлежит: Department of Bioproducts and Biosystems Engineering of University of Minnesota, Toyota Motor Corp, Toyota Motor Engineering and Manufacturing North America Inc

Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

Подробнее

Номер записи: 29

14-03-2013 дата публикации

Silicone Containing Compositions and Uses Thereof

Номер: US20130065998A1

Автор: Christine Anne Suzanne Louis, Kuo-Tsai Griffin Lai, Suresh Kalpatu Rajaraman

Принадлежит: Air Products and Chemicals Inc

Hydrogen, methyl, acetyl or butyl capped Polyether modified Silicone (PES) containing compositions are disclosed. The PES containing compositions can be used as defoamers or deaerators in coating compositions and, in particular, for airless sprayed compositions.

Подробнее

Номер записи: 30

21-03-2013 дата публикации

MEMBRANE ENHANCED POLYMER SYNTHESIS

Номер: US20130072691A1

Автор: Campos Vasconcelos Renato, Gaffney Piers Robert James, Livingston Andrew Guy

Принадлежит: IMPERIAL INNOVATIONS LIMITED

This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers. 1. A process for the preparation of heterobifunctional or mono-disperse polymers comprising the following steps:(a) reacting an excess of an initial polymer dissolved in a solvent with a branch point molecule to form a polymer mixture containing at least the initial polymer and a conjugate comprising at least two polymer molecules covalently bound to the branch point molecule such that each polymer molecule has a terminal which is bound to the branch point molecule and at least one unbound terminal;(b) contacting the polymer mixture with a semi-permeable membrane which has a rejection for the conjugate which is greater than the rejection for the initial polymer, so that the ratio between the concentrations of the conjugate and the initial polymer in the retentate is increased; and(c) cleaving the polymer from the branch point molecule of the conjugate;wherein the at least one unbound terminal of the polymer molecule of the conjugate is chemically modified to either modify the functionality of the unbound terminal of the polymer or add additional monomer or polymer units to the polymer and said modification occurs either prior to or subsequent to step (b) such that the polymer cleaved from branch point molecule comprises the initial polymer comprising at least one chemically modified terminal.2. A process as in claim 1 , wherein the process is a process for the preparation of heterobifunctional polymers and said chemical modification involves the removal of any protecting groups that may be present at the unbound terminal of the polymer followed by the functionalisation of the unbound terminal.3. A process according to claim 1 , wherein the process is a process for ...

Подробнее

Номер записи: 31

28-03-2013 дата публикации

Method for Preparing a Polymer Conjugate

Номер: US20130079533A1

Автор: Zhang Wen

Принадлежит: Nektar Therapeutics

Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to a taxane. The method involves, among other things, a step of reacting a taxame with a polyethylene glycol polymer comprising a functional group reactive with a functional group within said taxane in the presence of a coupling reagent and DPTS. The result of the reacting step is the formation of a polyethylene glycol-taxane conjugate. 2. The method of claim 1 , wherein said coupling reagent is a carbodiimide.3. The method of claim 2 , wherein said coupling reagent is selected from the group consisting of dicyclohexylcarbodiimide (DCC) claim 2 , N claim 2 ,N′-diisopropylcarbodiimide (DIC) claim 2 , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDAC) claim 2 , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) claim 2 , N-tert-butyl-N′-methylcarbodiimide (TBMC) claim 2 , and N-tert-butyl-N′-ethylcarbodiimide (TBEC).4. The method of claim 1 , wherein said coupling reagent is N claim 1 ,N′-diisopropylcarbodiimide.54. The method of any one of to claim 1 , wherein said reacting step is carried out in an organic solvent selected from the group consisting of dichloromethane claim 1 , chloroform claim 1 , acetonitrile and tetrahydrofuran.6. The method of claim 5 , wherein said reacting step is carried out at a temperature ranging from 0° C. to 100° C.7. The method of claim 6 , wherein said reacting step is carried out at room temperature.84. The method of any one of - claim 1 , wherein the amount of DPTS in said reacting step ranges from about 0.05 to 0.75 equivalents relative to said functional group within said taxane.9. The method of claim 8 , wherein the amount of DPTS in said reacting step ranges from about 0.10 to 0.60 equivalents relative to said functional group within said taxane.104. The method of any one of - claim 1 , wherein the amount of said coupling reagent ranges from about 1.25 to 5 equivalents relative to said functional group ...

Подробнее

Номер записи: 32

18-04-2013 дата публикации

Reagents and methods for phosphorylation/dephosphorylation analyses

Номер: US20130095502A1

Автор: Anton B. Iliuk, Weiguo A. Tao

Принадлежит: PURDUE RESEARCH FOUNDATION

Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that produces a signal or that binds to a molecule that produces a signal. The reagent may also include a moiety that binds to a larger molecule or to a surface. Some forms of the reagent include a dendrimer that can simultaneously bind to multiple metal moieties that include a metal such as titanium and multiple moieties that can be used to detected bound molecules. These reagents can be used in detection and/or measurement and/or at least partial purification of phosphorylated molecules. These reagents and methods using them are used to analyze proteins, polypeptides, nucleic acids, phospholipids and the like. They are readily adapted for use in gels, blots, plate based high through put assays and for mass spectrometry.

Подробнее

Номер записи: 33

18-04-2013 дата публикации

siRNA conjugate and preparation method thereof

Номер: US20130096288A1

Автор: Han Bo Ram, Lee Sam Young, Park Han Oh, Shin Mi Sik

Принадлежит: BIONEER CORPORATION

Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system. 1. A conjugate of survivin-specific siRNA and polymer compound , of the structure below:{'br': None, 'A-X—R—Y—B'}(where, one of A and B is a hydrophilic polymer compound and the other thereof is a hydrophobic polymer compound; X and Y each are independently a simple covalent bond or a linker-mediated covalent bond; and R is a survivin-specific siRNA.)2. The conjugate of claim 1 , wherein a single strand of the survivin-specific siRNA (R) is composed of 19 to 31 nucleotides.3. The conjugate of claim 1 , wherein the survivin-specific siRNA (R) is any one selected from nucleotide sequences of SEQ ID NOs.: 1 to 4.4. The conjugate of claim 1 , wherein the survivin-specific siRNA(R) has chemical modification.5. The conjugate of claim 4 , wherein the chemical modification includes at least one selected from:modifying a phosphorodiester bond into a phosphorothioate linkage;{'sub': '3', 'modifying —OH at the 2′-position of a pentose into 2′-OCHor 2′-dioxy-2′-fluouridine; and'}modifying —OH at the 2′ position of the pentose into an LNA type formed by linking the 2′ position and the 4′ position of the pentose.6. The conjugate of claim 1 , wherein the hydrophobic polymer compound has a molecular weight of 250 to 1 claim 1 ,000; the hydrophilic polymer compound is a non-ionic polymer ...

Подробнее

Номер записи: 34

25-04-2013 дата публикации

Protein-Polymer-Drug Conjugates

Номер: US20130101546A1

Автор: Bodyak Natalya D., Conlon Patrick R., Gumerov Dmitry R., Hammond Charles E., Lowinger Timothy B., Stevenson Cheri A., Thomas Joshua D., Yin Mao, Yurkovetskiy Aleksandr V.

Принадлежит: MERSANA THERAPEUTICS, INC.

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight≦5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. 2. The scaffold of claim 1 , wherein the PHF has a molecular weight ranging from 30 kDa to 100 kDa claim 1 , mis an integer from 3 to about 100 claim 1 , mis an integer from 1 to 40 claim 1 , and mis an integer from 1 to 220.3. The scaffold of claim 1 , wherein the functional group of Lis selected from —SR claim 1 , —S—S-LG claim 1 , maleimido claim 1 , and halo claim 1 , in which LG is a leaving group and Ris H or a sulfur protecting group.5. The scaffold of claim 1 , wherein Lcontains a biodegradable bond.6. The scaffold of claim 1 , further comprising a PBRM connected to the polymeric carrier via L.8. The scaffold of claim 7 , wherein the PHF has a molecular weight ranging from 30 kDa to 100 kDa claim 7 , mis an integer from 1 to 220 claim 7 , mis an integer from 3 to 100 claim 7 , mis an integer from 0 to 40 claim 7 , and mis an integer from 1 to 20 claim 7 , and the sum of mand mis an integer from 18 to 220 claim 7 , and the sum of mand mis an integer from 1 to 40.9. The scaffold of claim 7 , wherein mis an integer from 3 to about 150 and the sum of mand mis an integer from 14 to 330.10. The scaffold of claim 7 , wherein mis an integer from 1 to about 10.11. The scaffold of claim 7 , wherein each occurrence of PBRM independently has a molecular ...

Подробнее

Номер записи: 35

02-05-2013 дата публикации

Plasticizers for Adhesive, Coating and Sealant Compositions Applied to Asphalt

Номер: US20130108882A1

Автор: Jonathan T. Stuart, William J. Werts

Принадлежит: Henry Co LLC

An asphalt-containing substrate having an adhesive, coating or sealant composition applied to the substrate surface and adhesive, coating or sealant compositions are described herein. The composition resists softening of the asphalt compound in the asphalt-containing substrate at elevated temperatures and includes at least one base material and at least one plasticizer. The plasticizer has is a low molecular weight compound and preferably includes an ester-containing reaction product of at least one glycerol and at least one carboxylic acid or a glycol and an aryl carboxylic acid. The composition base material is preferably a polymer or copolymer that includes polyurethanes, silylated polyurethanes, silylated polyethers, copolymers thereof, and blends thereof. Products containing the composition and a method of applying the composition to a substrate are also disclosed herein.

Подробнее

Номер записи: 36

09-05-2013 дата публикации

In-vivo gelling pharmaceutical pre-formulation

Номер: US20130116341A1

Автор: George Horng, Syed H. Askari

Принадлежит: Medicus Biosciences LLC

Provided herein are in vivo gelling pharmaceutical pre-formulations forming biocompatible hydrogel polymers that are polymerized in vivo and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure.

Подробнее

Номер записи: 37

09-05-2013 дата публикации

MODIFIED MACROMOLECULE

Номер: US20130116432A1

Автор: Boyd Benjamin James, Kaminskas Lisa Michelle, Karellas Peter, Kelly Brian Devlin, Krippner Guy Yeoman, Pallich Sue, Porter Christopher John Hamilton, Razzino Pasquale, Wu Zemin

Принадлежит: STARPHARMA PTY LTD

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups. 1. A macromolecule having controlled terminal group stoichiometry and including at least one lysine or lysine analogue dendritic motif having a surface layer and at least one subsurface layer , the macromolecule including at least two terminal groups including:a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefore, anda second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule,wherein terminal group stoichiometry refers to the number and type of terminal groups.2. The macromolecule according to claim 1 , wherein the lysine or lysine dendritic motif or the macromolecule further exhibits controlled topology claim 1 , wherein topology describes the relationship between one terminal group and another in terms of its connection to the surface or subsurface layers of the macromolecule.3. The macromolecule according to claim 1 , wherein the second terminal group is polyethylene glycol (PEG) or polyethyloxazoline.4. The macromolecule according to claim 1 , wherein the second terminal group is a residue of folate or a folate derivative.5. The macromolecule according to claim 1 , wherein the pharmaceutically active agent is selected from the group consisting of: methotrexate; taxol; indomethacin; zenical; and cyclosporine.6. The macromolecule according to claim 1 , wherein the second terminal group is ...

Подробнее

Номер записи: 38

09-05-2013 дата публикации

Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome

Номер: US20130116461A1

Автор: Fumiaki Manabe, Yuji Yamamoto

Принадлежит: NOF Corp

Provided is a polyethylene glycol derivative which contains two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes. Polyethylene glycol is represented by the following formula (1) and which is bound to a diacylglycerol: In Formula (1), R 1 is a hydrocarbon group containing 1 to 7 carbon atoms, R 2 is an alkyl or alkenyl group containing 9 to 21 carbon atoms, n is the average number of moles of added polyethylene glycol chains, 10 n 100, and X is a linker site between branched polyethylene glycol and the diacylglycerol and is represented by the following formula (2): In Formula (2), Y is an ether bond, an ester bond, a urethane bond, an amide bond, or a carbonate bond and 1 and m are an integer of 0 to 6.

Подробнее

Номер записи: 39

16-05-2013 дата публикации

Derivatized Hyperbranched Polyglycerols

Номер: US20130122112A1

Автор: BROOKS Donald, Burt Helen M., Gleave Martin E., Guan Dechi, Jackson John K., Kainthan Rajesh Kumar, KIZHAKKEDATHU Jayachandran, Liggins Richard, Mugabe Clement, So Alan, YE Lu

Принадлежит:

Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with CCalkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs. 1. A hyperbranched polyglycerol , comprising:{'sub': 1', '20, 'a core comprising hyperbranched polyglycerol derivatized with C-Calkyl chains; and'}{'sub': 2', '2', '3', '3', '1', '6', '1', '6', '3', '12', '3, 'sup': +', '+', '+, "a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the at least one hydrophilic substituent comprises at least one functional group selected from one or more of the following: —NH, ═NH, —NH, and —NR, wherein each R is independently a C-Calkyl group or one R is independently a C-Calkyl group and two R's together form a C-Ccyclic alkyl group so that Rforms a quaternary amine with the nitrogen, and"}wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one functional group per mole of the hyperbranched polyglycerol.2. The hyperbranched polyglycerol of claim 1 , wherein the at least one functional group is —NH.3. The hyperbranched polyglycerol of claim 1 , wherein the at least one hydrophilic substituent is methoxy polyethylene glycol (MePEG) claim ...

Подробнее

Номер записи: 40

16-05-2013 дата публикации

ALLERGEN REDUCING AGENT, AND PROCESSED PRODUCT, COATING MATERIAL, AND WOOD BUILDING MATERIAL USING SAME

Номер: US20130122319A1

Автор: Fukuzawa Shigeharu, Nakamoto Shoichi, Omura Hiroyuki, Rokushima Kazumasa, Sakamoto Kenji

Принадлежит: Panasonic Corporation

An allergen reducing agent is provided that contains a terpenoid polymer or copolymer as an active component, and that functions to reduce allergens such as mites and pollen, and is capable of suppressing coloring. 1. An allergen reducing agent that comprises a terpenoid polymer or copolymer as an active component.2. The allergen reducing agent according to claim 1 , wherein the terpenoid copolymer is a copolymer of terpenoid and an aromatic monomer.3. The allergen reducing agent according to claim 1 , wherein the terpenoid copolymer is a copolymer of terpenoid and phenol.4. The allergen reducing agent according to claim 3 , wherein the copolymer of terpenoid and phenol has a hydroxyl number of 10 to 250 mgKOH/g.5. The allergen reducing agent according to claim 1 , wherein the terpenoid is monoterpene.6. The allergen reducing agent according to claim 5 , wherein the monoterpene is limonene or pinene.7. The allergen reducing agent according to claim 1 , wherein a double bond derived from the terpenoid is hydrogenated by a reaction with hydrogen.8. A processed product that comprises the allergen reducing agent of fixed to a surface of the processed product.9. A coating material that contains the allergen reducing agent of claim 1 , and a curable resin.10. A wood building material that comprises a single or multiple functional layers on a surface of a wood base claim 9 , wherein a layer forming the outermost surface of the single or multiple functional layers is a cured coating of the coating material of claim . The present invention relates to allergen reducing agents, and processed products, coating materials, and wood building materials using same.In Japan, one in three people is said to suffer from allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis. Allergic diseases are caused by substances such as mites, pollen, fungi, and pet hairs. Particularly problematic are the allergens from house dust mites, which account for 70% or more ...

Подробнее

Номер записи: 41

23-05-2013 дата публикации

PROCESS FOR PREPARING POLYMER POLYOLS

Номер: US20130131204A1

Автор: Fennis Paulus Jacobus, Lelieveld Martinus Johannes Maria

Принадлежит:

The invention relates to a process for the preparation of a polymer polyol, which process comprises mixing in a reactor vessel a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200 ° C., wherein the monomer(s) and initiator are dosed simultaneously to the reactor vessel and wherein during the time period of simultaneously dosing the monomer(s) and initiator the dosing weight ratio of initiator to monomer(s) is increased. 1. A process for the preparation of a polymer polyol , which process comprises mixing in a reactor vessel a base polyol , one or more ethylenically unsaturated monomers , a polymerization initiator , optionally a macromer , and optionally a chain transfer agent , and polymerizing the mixture thus obtained at a temperature of 50 to 200° C. , wherein the monomer(s) and initiator are dosed substantially simultaneously to the reactor vessel and wherein during the time period of substantially simultaneously dosing the monomer(s) and initiator the dosing weight ratio of initiator to monomer(s) is increased.2. The process of claim 1 , wherein the initiator comprises a peroxide compound.4. The process of claim 3 , wherein at least one of R5 claim 3 , R6 and R7 is an alkyl group and is selected from a methyl group claim 3 , an ethyl group or a tertiary butyl group5. The process of claim 3 , wherein R2 is selected from: tertiary-butyl claim 3 , 1 claim 3 ,1-dimethylpropyl claim 3 , 1 claim 3 ,1-dimethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,3-trimethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,3 claim 3 ,3-tetramethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,2-trimethylpropyl claim 3 , 1 claim 3 ,1 claim 3 ,2 claim 3 ,2-tetramethylpropyl or 1 claim 3 ,1 claim 3 ,2 claim 3 ,2-tetramethylbutyl.7. The process of claim 6 , wherein R2 is 1 claim 6 ,1-dimethylbutyl claim 6 , 1 claim 6 ,1 claim 6 ,3- ...

Подробнее

Номер записи: 42

23-05-2013 дата публикации

PROCESS FOR PREPARING POLYMER POLYOLS

Номер: US20130131205A1

Автор: Fennis Paulus Jacobus, Karzijn Willem, Lelieveld Martinus Johannes Maria

Принадлежит:

The invention relates to a process for the preparation of a polymer polyol which is at most 60 wt. %, which process comprises mixing a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200° C., optionally below 120 C, wherein the initiator is of formula R—C(═O)—O—O—R(I) wherein Ris an alkyl group and Ris an alkyl group of formula —C(R)(R)—C(R)(R)(R) (II) wherein Rand Rare the same or different and are an alkyl group, R, Rand Rare the same or different and are a hydrogen atom or an alkyl group. 1. A process for the preparation of a polymer polyol having a solid polymer content which is at most 60 wt. % , which process comprises mixing a base polyol , one or more ethylenically unsaturated monomers , a polymerization initiator , optionally a macromer , and optionally a chain transfer agent , and polymerizing the mixture thus obtained at a temperature of below 120° C. , wherein the initiator is of formula{'br': None, 'R1—C(═O)—O—O—R2\u2003\u2003(I)'} {'br': None, '—C(R3)(R4)—C(R5)(R6)(R7)\u2003\u2003(II)'}, 'wherein R1 is an alkyl group and R2 is an alkyl group of formula'}wherein R3 and R4 are the same or different and are an alkyl group, R5, R6 and R7 are the same or different and are a hydrogen atom or an alkyl group.2. The process of claim 1 , wherein R1 is an alkyl group having up to 10 carbon atoms.3. The process of claim 1 , wherein at least one of R5 claim 1 , R6 and R7 is an alkyl group and is selected from a methyl group claim 1 , an ethyl group or a tertiary butyl group4. The process of claim 1 , wherein R2 is selected from: tertiary-butyl claim 1 , 1 claim 1 ,1-dimethylpropyl claim 1 , 1 claim 1 ,1-dimethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,3-trimethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,3 claim 1 ,3-tetramethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,2-trimethylpropyl claim 1 , 1 claim 1 , ...

Подробнее

Номер записи: 43

20-06-2013 дата публикации

Multi-arm polymer prodrugs

Номер: US20130158062A1

Автор: Michael David Bentley, Tacey X. Viegas, Xuan Zhao, Zhongxu Ren

Принадлежит: Nektar Therapeutics

Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

Подробнее

Номер записи: 44

04-07-2013 дата публикации

BLOCK COPOLYMERS ON THE BASIS OF (METH)ACRYLATE

Номер: US20130172511A1

Автор: Balk Sven, Erb Volker, Fengler Stephan, Franken Uwe, Kautz Holger, Kinzelmann Hans-Georg, Kuppert Dirk, Moeller Thomas, Pieroth Rebecca, Staschik Dorothea, Zander Lars

Принадлежит:

The invention relates to block copolymers produced by means of controlled polymerization and that have at least one block A or B comprising (meth)acrylate monomers and copolymerizable monomers, and a block P on the basis of functionalized polymers. 2. The block copolymer according to claim 1 , wherein all OH claim 1 , SH claim 1 , RNH groups of P are functionalized with an initiator building block and reacted to give an A and/or B block.3. The block copolymer according to claim 1 , wherein block A and/or block B is a multi-block with the structure (AB)n or (BA)n claim 1 , where n=1 to 10.4. The block copolymer according to claim 1 , wherein block A is a homopolymer or copolymer claim 1 , taking the form of a gradient or random polymer in the case of a copolymer.5. The block copolymer according to claim 1 , wherein block P has a functionality of 1 to 10.6. The block copolymer according to claim 1 , wherein blocks A or B each have one or more functional groups.7. The block copolymer according to claim 6 , wherein blocks A or B lying at the end of the polymer have one functional group in the terminal position.8. The block copolymer according to claim 1 , wherein block A is largely or exclusively constructed from vinyl-substituted aromatic monomers.9. The block copolymer according to claim 1 , wherein blocks A and B are produced by ATRP polymerization.10. The block copolymer according to claim 1 , wherein the polymer building block P is a polyether diol or polyether triol produced on the basis of ethylene glycol claim 1 , propylene glycol or tetrahydrofuran claim 1 , or a polyester diol or triol produced from aliphatic and/or aromatic dicarboxylic acids with low-molecular-weight diols claim 1 , in particular having a molecular weight of 400 to 20 claim 1 ,000 g/mol.11. A method for producing block copolymers comprising a block P and at least one block A and block B claim 1 , wherein a polymer building block containing OH claim 1 , SH claim 1 , RNH groups is used as ...

Подробнее

Номер записи: 45

18-07-2013 дата публикации

ANTIMICROBIAL POLYMERIC COMPOSITIONS

Номер: US20130183262A1

Автор: Chakrabarty Souvik, Chakravorty Asima, Oyesanya Olufemi O., Wynne Kenneth J., ZHANG Wei

Принадлежит:

A compound having the formula: 3. A polymer , comprising a polymerization product of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(A) the compound of ;'}(B) one or more of an isocyanate, diisocyanate, or combination thereof;(C) optionally, a diol or diamine chain extender; and(D) optionally, a diol selected from the group polydimethylsiloxane diol, polytetramethylene oxide diol, polypropylene oxide diol, polyethylene oxide diol, polybutadiene diol, polyisobutylene diol, perfluorinated diol or a combination of two or more thereof.10. The composition of claim 9 , which is a blend of (a) and (b).19. A method claim 9 , comprising: (a) at least one selected from the group consisting of polyurethane polymer, polyurethane copolymer, or a combination thereof; and', '(b) at least one selected from the group consisting of non-polar solvent, pentane, cyclopentane, hexane, cyclohexane, benzene, toluene, 1,4-dioxane, chloroform, diethyl ether, polar aprotic solvent, tetrahydrofuran, dichloromethane, ethyl acetate, acetone, dimethylformamide, acetonitrile, dimethyl sulfoxide, propylene carbonate, or a combination thereof; and', '(c) at least one selected from the group consisting of polar protic solvent, water, methanol, ethanol, propanol, isopropanol, n-butanol, formic acid, or a combination thereof;, 'contactingand thereafter separating, to produce a purified polyurethane polymer, polyurethane copolymer, or a combination thereof.20. A method for making a polymer claim 19 , comprising the method of .21. A polymer claim 19 , produced by the method of .22. An article or device claim 3 , comprising the polymer of on a surface thereof.23. An article or device claim 7 , comprising the composition of on a surface thereof.24. An article or device claim 9 , comprising the composition of on a surface thereof.25. An article or device claim 15 , comprising the polymer of on a surface thereof.26. A method for killing a microbe claim 17 , comprising contacting said microbe with the ...

Подробнее

Номер записи: 46

18-07-2013 дата публикации

Monomer composition containing unsaturated polyalkylene glycol ether-based monomer, method for producing composition thereof, polymer obtained using composition thereof, and method for producing polymer thereof

Номер: US20130184420A1

Автор: Hiroshi Kawabata

Принадлежит: NIPPON SHOKUBAI CO LTD

To provide a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer and having excellent stability. Provided is a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R 1 O) n R 2 (1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R 1 O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition mole number of oxyalkylene groups and is a number of 5 to 500; and R 2 represents a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.

Подробнее

Номер записи: 47

01-08-2013 дата публикации

Synergistic biomolecule-polymer conjugates

Номер: US20130195799A1

Автор: Chyi Lee

Принадлежит: PEG BIOSCIENCES Inc

The synergistic biomolecule-polymer conjugates are the long-acting, in vivo controlled continuous-release and hybrid synergy systems of biomolecules that provide increased biological activities and enhanced pharmacological properties for achieving greater therapeutic efficacies.

Подробнее

Номер записи: 48

05-09-2013 дата публикации

METHOD FOR PREPARING WATER-SOLUBLE POLYMER DERIVATIVES BEARING AN N-SUCCINIMIDYL ESTER

Номер: US20130231490A1

Автор: Kozlowski Antoni

Принадлежит: Nektar Therapeutics

A method is provided for preparing water-soluble polymer derivatives bearing a terminal N-succinimidyl ester. The method involves the hydrolyzing an ortho ester of a water-soluble polymer so as provide the corresponding acid and subsequently esterifying the acid. 2. The method of claim 1 , wherein the water-soluble polymer is branched.3. The method of claim 1 , wherein the water-soluble polymer is linear.4. The method of claim 1 , wherein (z) equals three.5. The method of claim 1 , wherein each occurrence of Rand Ris H.6. The method of claim 1 , wherein each Rcombines with another Ror the remaining Rmoieties to form an ortho ester cyclic structure.8. The method of claim 1 , wherein the water-soluble polymer is selected from the group consisting of a poly(alkylene oxide) claim 1 , poly(vinyl pyrrolidone) claim 1 , poly(vinyl alcohol) claim 1 , polyoxazoline claim 1 , poly(acryloylmorpholine) claim 1 , and poly(oxyethylated polyol).9. The method of claim 8 , wherein the water-soluble polymer is a poly(alkylene oxide).10. The method of claim 9 , wherein the poly(alkylene oxide) is a poly(ethylene glycol).11. The method of claim 10 , wherein the poly(ethylene glycol) has a molecular weight of from about 5 claim 10 ,000 Daltons to about 100 claim 10 ,000 Daltons.12. The method of claim 11 , wherein the poly(ethylene glycol) has a molecular weight of from about 5 claim 11 ,000 Daltons to about 25 claim 11 ,000 Daltons.14. The method of claim 1 , wherein conducting acid-catalyzed hydrolysis includes the use of an acid selected from the group consisting of hydrofluoric acid claim 1 , hydrochloric acid claim 1 , hydrobromic acid claim 1 , hydroiodic acid claim 1 , nitric acid claim 1 , perchloric acid claim 1 , sulfuric acid claim 1 , acetic acid claim 1 , carbonic acid claim 1 , phosphoric acid claim 1 , oxalic acid and formic acid.15. The method of claim 1 , wherein conducting acid catalyzed-hydrolysis includes the use of p-toluenesulfonic acid and pyridine in water.16. ...

Подробнее

Номер записи: 49

19-09-2013 дата публикации

POLYMERIC CONJUGATES OF ACTIVE PRINCIPLES, THEIR PROCESS OF PREPARATION AND THEIR POLYMERIC INTERMEDIATES

Номер: US20130243719A1

Автор: Amgoune Abderrhamane, Bazile Didier, Bensaid Fethi, Bourissou Didier, Didier Eric, Greco Stephanie, Lakkireddy Harivardhan Reddy, Sable Serge, Veillard Michel

Принадлежит:

The present invention relates to novel conjugates of active principles grafted to a polymer, to the nanoparticles comprising them, to their preparation and to their polymeric intermediates. 2. Conjugate according to claim 1 , such that the AP residue is bonded to L by means of an OH group present in the AP.3. Conjugate according to claim 1 , such that the said AP is a taxoid.4. Conjugate according to claim 3 , such that the said taxoid is selected from paclitaxel claim 3 , docetaxel claim 3 , cabazitaxel and larotaxel.5. Conjugate according to claim 1 , such that the said active principle is cabazitaxel claim 1 , grafted in the 2′ position.6. Conjugate according to claim 1 , such that the said PLA exhibits claim 1 , at its optionally remaining free hydroxyl end claim 1 , a protective group.9. Conjugate according to claim 1 , such that L represents a dicarboxylate derivative of succinic acid claim 1 , glutaric acid or diglycolic acid.14. Process according to such that stage 2 is carried out by ring opening polymerization (ROP) by means of the precursor 3 claim 12 ,6-dimethyl-[1 claim 12 ,4]-dioxane-2 claim 12 ,5-dione.15. Nanoparticles comprising a conjugate according to .16. Pharmaceutical composition comprising a conjugate according to .17. A method for the treatment and/or prevention of cancers in a patient in need thereof comprising administering to said patient a therapeutically effective amount of the conjugate of . The present invention relates to polymeric conjugates of active principles, in particular of taxoids.Taxoids have generally in common a very low solubility in water. Thus, the taxol is formulated in a mixture of cremophor and alcohol which causes significant side effects, such as hypersensitivity, nephrotoxicity, cardiotoxicity and neurotoxicity. Alternative formulations have been sought for; in particular, water-soluble formulations based on polymers, such as microspheres, nanoparticles and micelles, have been explored with the objective of ...

Подробнее

Номер записи: 50

19-09-2013 дата публикации

POLYPHENYLENE ETHER POWDER AND POLYPHENYLENE ETHER RESIN COMPOSITION

Номер: US20130245182A1

Автор: Kondo Tomohiro

Принадлежит: ASAHI KASEI CHEMICALS CORPORATION

An object of the present invention is to provide a polyphenylene ether powder that has a high loose apparent specific gravity and good handleability, as well as a high solvent solubility, and good covering properties by coating, applying and the like, and further, when formed as a covering film, providing the covering film with excellent mechanical properties. The polyphenylene ether powder according to the present invention has a loose apparent specific gravity of 0.40 or more and 0.85 or less, and includes 5 to 20 mass % of a component having a molecular weight of 50,000 or more and 12 to 30 mass % of a component having a molecular weight of 8,000 or less. 1. A polyphenylene ether powder having a loose apparent specific gravity of 0.40 or more and 0.85 or less , and comprising 5 to 20 mass % of a component having a molecular weight of 50 ,000 or more and 12 to 30 mass % of a component having a molecular weight of 8 ,000 or less.2. The polyphenylene ether powder according to claim 1 , which has a reduced viscosity (ηsp/c) of 0.20 dl/g or more and 0.43 dl/g or less.3. A polyphenylene ether resin composition claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) the polyphenylene ether powder according to ; and'}(b) a good solvent for the polyphenylene ether powder.4. The polyphenylene ether resin composition according to claim 3 , wherein (b) the good solvent is one or more solvents selected from the group consisting of aromatic hydrocarbons claim 3 , halogenated hydrocarbons claim 3 , nitro compounds claim 3 , aliphatic hydrocarbons claim 3 , and ethers.5. The polyphenylene ether resin composition according to claim 3 , wherein a mass ratio ((a)/(b)) of (a) the polyphenylene ether powder to (b) the good solvent is 5/95 to 60/40.6. A polyphenylene ether resin composition claim 3 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(a) the polyphenylene ether powder according to ; and'}(d) a filler.7. The polyphenylene ether resin ...

Подробнее

Номер записи: 51

10-10-2013 дата публикации

CURABLE RESIN COMPOSITION

Номер: US20130266779A1

Автор: ENDO Masaaki, Tokiwa Tetsuji, UTSUMI Takamitsu

Принадлежит: ASAHI KASEI E-MATERIALS CORPORATION

Provided is a curable resin composition which can provide a cured article having a low dielectric constant and a low dielectric tangent, and can also provide a cured article having excellent moldability at ordinary press-molding temperatures, excellent heat resistance and excellent adhesion properties. The present invention provides a curable resin composition containing a polyphenylene ether, wherein the average number of phenolic hydroxy groups is 0.3 or more per molecule of the polyphenylene ether, the resin flow amount of the curable resin composition upon curing is 0.3 to 15% inclusive, and a cured article having a dielectric tangent of 0.005 or less at 1 GHz and a glass transition temperature of 170° C. or higher can be produced. 19.-. (canceled)10. A curable resin composition comprising a polyphenylene ether , wherein:the average number of phenolic hydroxyl groups per molecule of said polyphenylene ether is 0.3 or more,the resin flow rate of said curable resin composition at curing as measured under the following conditions is from 0.3 to 15%,a sample for dielectric loss tangent measurement produced from said curable resin composition under the following conditions has a dielectric loss tangent at 1 GHz of 0.005 or less,a sample for glass transition temperature measurement produced from said curable resin composition under the following conditions has a glass transition temperature of 170° C. or more, {'br': None, 'Resin flow rate (%) at curing=(mass (g) of laminate sheet precursor−mass (g) of laminate sheet)/mass (g) of laminate sheet precursor×100,'}, 'assuming that two 150 mm-square prepreg sheets obtained by impregnating a glass cloth specified by IPC Style 2116 with said curable resin composition to have a resin content of 60±2 mass % are stacked to obtain a laminate sheet precursor and a laminate sheet is produced by molding said laminate sheet precursor under the following condition (a) and removing the resin part flowed out, said resin flow rate at ...

Подробнее

Номер записи: 52

17-10-2013 дата публикации

HIGHLY PURE POLOXAMERS AND PURIFICATION METHOD THEREOF

Номер: US20130274421A1

Автор: Kim Bong Oh, Seo Min Hyo

Принадлежит: SAMYANG BIOPHARMACEUTICALS CORPORATION

Disclosed are a method for purifying poloxamers, comprising dissolving poloxamers in an organic solvent to prepare a polymer solution, and removing organometals or water from the polymer solution by at least one physical method selected from mixing of activated carbon with the polymer solution and centrifugation of the polymer solution, and poloxamers purified by the method.

Подробнее

Номер записи: 53

17-10-2013 дата публикации

Use of Molecules Having Associative Groups As Hardeners for Thermosetting Resins

Номер: US20130274432A1

Автор: Hidalgo Manuel, Van Hemelryck Bruno

Принадлежит:

The present invention pertains to the field of thermosetting or thermoset polymers mainly used as materials, coatings or adhesives. The invention more specifically relates to the use of specific molecules having associative groups including a nitrogen heterocycle as a hardener or co-hardener of thermosetting polymers. 2. The thermosetting formulation as claimed in claim 1 , wherein R is chosen from HN—(CH)— claim 1 , HS—(CH)— or HO—(CH)— claim 1 , where n represents an integer between 1 and 18.3. The thermosetting formulation as claimed in claim 1 , wherein said molecule of formula (I) is chosen from: 1-(2-aminoethyl)imidazolidone claim 1 , 1-(2-hydroxyethyl)imidazolidone claim 1 , 1-(2-[(2-aminoethyl)amino]ethyl)imidazolidone claim 1 , 1-(2-[2-{2-aminoethylamino}ethylamino]ethyl)imidazolidone or N-(6-aminohexyl)-N′-(6-methyl-4-oxo-1 claim 1 ,4-dihydropyrimidin-2-yl)urea.4. The thermosetting formulation as claimed in claim 1 , wherein the co-curing agent is chosen from alkyl- or arylamines and in particular ethylenediamine claim 1 , diethylenetriamine claim 1 , triethylenetetramine and tetraethylenepentamine claim 1 , cyclic diamines claim 1 , in particular 1-2-diaminocyclohexane claim 1 , isophoronediamine or N claim 1 ,N′-diisopropylisophoronediamine claim 1 , aromatic primary diamines claim 1 , in particular 4 claim 1 ,4′-methylenedianiline claim 1 , 4 claim 1 ,4′-methylenebis(ortho-chloroaniline) or xylenediamine isomers claim 1 , such as diethyltoluenediamine claim 1 , hydroxyethyldiethylenetriamine claim 1 , polyetheramines claim 1 , BADGE-aliphatic amine adducts with an excess of amine functional groups relative to the glycidyls claim 1 , polyamidoamines claim 1 , polyamides claim 1 , amidoamines claim 1 , polymercaptans claim 1 , the Mannich bases obtained by reaction between (poly)amine claim 1 , formaldehyde and (alkyl)phenols claim 1 , ketimines claim 1 , dicyanodiamide claim 1 , polyol epoxy resins and polyurethane-curing polyols.5. The thermosetting ...

Подробнее

Номер записи: 54

24-10-2013 дата публикации

POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD

Номер: US20130280783A1

Автор: Culbertson Sean M., Kozlowski Antoni, McManus Samuel P., Shen Xiaoming

Принадлежит:

Provided herein are polymeric α-hydroxy aldehyde or α-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable conjugates in a single-step reaction. In selected embodiments, the polymeric reagent itself incorporates an internal proton-abstracting (basic) functional group, to promote more efficient reaction. The substituent is appropriately situated, via a linker if necessary, to position the group for proton abstraction, preferably providing a 4- or 5-bond spacing between the abstracting atom and the hydrogen atom on the α-carbon. Also provided are methods of using the reagents and stable, solubilized conjugates of the reagents with biologically active compounds. In preferred embodiments, the polymeric component of the reagent or conjugate is a polyethylene glycol. 2. The reagent of claim 1 , wherein at most one group Ror Ris selected from aminoalkyl claim 1 , iminoalkyl claim 1 , carboxylic acid claim 1 , alkylcarboxylic acid claim 1 , phosphate claim 1 , and alkylphosphate.3. The reagent of claim 1 , wherein m is 0 to 6.4. The reagent of claim 1 , where POLY is a polyethylene glycol.5. The reagent of claim 1 , wherein one group Ror Ris selected from hydroxy claim 1 , alkoxy claim 1 , hydroxyalkyl claim 1 , alkoxyalkyl claim 1 , alkoxyalkylene claim 1 , amino claim 1 , aminoalkyl claim 1 , iminoalkyl claim 1 , carboxylic acid claim 1 , alkylcarboxylic acid claim 1 , phosphate claim 1 , and alkylphosphate; and said group Ror Rand the value of m are selected such that an oxygen or nitrogen atom on Ror Ris separated from Cα by a four-bond path.6. The reagent of claim 5 , wherein one group Ror Ris selected from amino claim 5 , aminoalkyl claim 5 , iminoalkyl claim 5 , carboxylic acid claim 5 , and alkylcarboxylic acid.7. The reagent of claim 4 , wherein Ris H or methyl.8. The reagent of claim 7 , wherein POLY is mPEG.9. The reagent of claim 8 , wherein Ris H claim 8 , m is 3 claim 8 , and —(CRR)— is selected from —(CH)— and —CH—CH(OH ...

Подробнее

Номер записи: 55

31-10-2013 дата публикации

Alkylene oxide polymerization using a double metal cyanide catalyst complex and a magnesium, group 3 - group 15 metal or lanthanide series metal compound

Номер: US20130289236A1

Автор: Carlos M. Villa, David A. Babb, David S. LAITAR, Jean-Paul Masy, Richard Keaton

Принадлежит: Dow Global Technologies LLC

Alkylene oxide polymerizations are performed in the presence of a double metal cyanide polymerization catalyst and certain magnesium, Group 3-Group 15 metal or lanthanide series metal compounds. The presence of the magnesium, Group 3-Group 15 metal or lanthanide series metal compound provides several benefits including more rapid catalyst activation, faster polymerization rates and the reduction in the amount of ultra high molecular weight polymers that are formed. The catalyst mixture is unexpectedly useful in making polyethers having low equivalent weights.

Подробнее

Номер записи: 56

31-10-2013 дата публикации

Methods for making polyglycerol

Номер: US20130289314A1

Автор: Marc Dube, Somaieh SALEHPOUR

Принадлежит: UNIVERSITY OF OTTAWA

Methods are provided for making polyglycerol. The methods include heating glycerol at reduced pressure in the absence of a glyceride and in the presence of a catalytic amount of an acid selected from the group consisting of sulfuric acid, triflic acid, hydrochloric acid, hexafluorophosphoric acid, tetrafluoroboric acid and mixtures thereof.

Подробнее

Номер записи: 57

14-11-2013 дата публикации

CURATIVES FOR EPOXY COMPOSITIONSERS

Номер: US20130299747A1

Автор: Dershem Stephen M.

Принадлежит:

The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions. 2. The composition of claim 1 , wherein each of R and Ris claim 1 , independently claim 1 , selected from the group consisting of a substituted or an unsubstituted alkyl claim 1 , cycloalkyl claim 1 , alkenyl claim 1 , aryl claim 1 , and heterocyclic moieties.3. The composition of claim 1 , wherein Ar is a substituted or an unsubstituted Cto about Caryl or a substituted or an unsubstituted Cto about Cheteroaryl.4. The composition of claim 1 , wherein n is 3 to about 11.5. (canceled)6. The composition of claim 1 , wherein Ris different than at least one R and optionally claim 1 , the at least one R is a terminal R group.7. (canceled)8. The composition of claim 1 , wherein the curative is a liquid at room temperature.1014-. (canceled)15. The composition of claim 1 , wherein the epoxy comprises at least one of a glycidyl ether epoxy compound claim 1 , a cycloaliphatic epoxy compound claim 1 , or an aliphatic epoxy compound.16. The composition of claim 15 , wherein the glycidyl ether epoxy compound is selected from the group consisting of:(a) a glycidyl ether of a phenol, an amine, an alcohol, or an isocyanurate;(b) a trisglycidyl ether of a phenolic compound;(c) a glycidyl ether of a cresol formaldehyde condensate;(d) a glycidyl ether of a phenol formaldehyde condensate;(e) a glycidyl ether of a cresol dicyclopentadiene addition compound;(f) a glycidyl ether of a phenol dicyclopentadiene addition compound;(g) a glycidyl ether of a fused ring polyaromatic phenol;(h) diglycidyl ether;(i) a glycidyl ether of ...

Подробнее

Номер записи: 58

21-11-2013 дата публикации

Auristatin Compounds and Conjugates Thereof

Номер: US20130309192A1

Автор: Aleksandr V. Yurkovetskiy, Charles E. Hammond, Cheri A. STEVENSON, Dmitry R. Gumerov, Joshua D. Thomas, MAO Yin, Natalya D. Bodyak, Patrick R. Conlon, Timothy B. Lowinger

Принадлежит: Mersana Therapeutics Inc

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L D -D, the protein based recognition-molecule being connected to the polymeric carrier by L P . Each occurrence of D is independently an Auristatin compound. L D and L P are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

Подробнее

Номер записи: 59

05-12-2013 дата публикации

POLY(PHENYLENE ETHER) FIBER AND METHOD OF MAKING

Номер: US20130324628A1

Автор: Hossan Robert John

Принадлежит:

A fiber comprises a composition including a poly(phenylene ether). The poly(phenylene ether) has less than or equal to 240 parts per million by weight of hydroxyl groups associated with ethylene bridge groups and less than or equal to 800 parts per million by weight of hydroxyl groups associated with rearranged backbone groups, both amounts based on the weight of the poly(phenylene ether). A method of spinning a fiber from the poly(phenylene ether) is disclosed. The fiber can be spun at a low denier. 1. A fiber comprising a composition comprising a poly(phenylene ether) , wherein the fiber comprises less than or equal to 240 parts per million by weight of hydroxyl groups associated with ethylene bridge groups and less than or equal to 800 parts per million by weight of hydroxyl groups associated with rearranged backbone groups , both amounts based on the weight of the poly(phenylene ether).2. The fiber of claim 1 , having a denier of less than or equal to 10.3. The fiber of claim 1 , wherein the composition comprises about 50 to 100 weight percent of the poly(phenylene ether) claim 1 , and 0 to about 50 weight percent of a poly(alkenyl aromatic); andwherein all weight percents are based on the total weight of the poly(phenylene ether) and the poly(alkenyl aromatic).4. The fiber of claim 3 , wherein the composition consists of the poly(phenylene ether) claim 3 , the poly(alkenyl aromatic) claim 3 , and optionally about 0.1 to about 10 weight percent claim 3 , based on the total weight of the composition claim 3 , of one or more additives selected from the group consisting of stabilizers claim 3 , antioxidants claim 3 , mold release agents claim 3 , processing aids claim 3 , flame retardants claim 3 , drip retardants claim 3 , nucleating agents claim 3 , UV blockers claim 3 , dyes claim 3 , pigments claim 3 , anti-static agents claim 3 , blowing agents claim 3 , mineral oil claim 3 , metal deactivators claim 3 , anti-blocking agents claim 3 , and conductive agents.5. ...

Подробнее

Номер записи: 60

12-12-2013 дата публикации

Polymeric corrosion inhibiter for metal surfaces and the production thereof

Номер: US20130330564A1

Автор: Felix Straetmans, Marko Soltau, Udo Straetmans

Принадлежит: STRAETMANS HIGHTAC GMBH

The invention relates to a polymeric corrosion inhibiter for a metal substrate of formula (R 1 ) a A(R 2 X) b , where a=0-3, b=1-6, A is a bridge structure unit, R 1 is identical to or different from H or an aliphatic, aromatic, olefinic, cyclic, heterocyclic, polycyclic or polyheterocyclic radical, R 2 is identical to or different from a polymeric basic structure, X is identical to or different from a functional group selected from the groups comprising: carboxylic acids; dicarboxylic acids; polycarboxylic acids; carboxylic acid anhydrides; carboxylic acid chlorides; carboxylic sulfonic acids; and also esters, amides and imides of the aforementioned groups, the molar mass of the polymer lies between 200 and 10,000, preferably 400 and 6,000. The invention further relates to the use of a polymeric corrosion inhibiter for the treatment of metal surfaces and to a method for producing a polymeric corrosion inhibiter.

Подробнее

Номер записи: 61

02-01-2014 дата публикации

ULTRAVIOLET RADIATION ABSORBING POLYETHERS

Номер: US20140004061A1

Автор: Daly Susan, Levins Christopher G., Nathan Aruna, Zavatsky Joseph F.

Принадлежит: JOHNSON & JOHNSON CONSUMER COMPANIES, INC.

A polymer composition comprising a linear ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore. 1. A polymer composition comprising a linear ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore.5. The polymer composition of claim 1 , comprising about 50% or more of said linear ultraviolet radiation absorbing polyether comprising the chemically bound UV-chromophore.6. The polymer composition of claim 1 , comprising about 90% or more of said linear ultraviolet radiation absorbing polyether comprising the chemically bound UV-chromophore.7. The polymer composition of claim 1 , comprising about 95% or more of said linear ultraviolet radiation absorbing polyether comprising the chemically bound UV-chromophore.8. The polymer composition of claim 1 , wherein the linear ultraviolet radiation absorbing polyether comprises a backbone having glyceryl repeat units.10. The polymer composition of claim 9 , wherein m is 1 and n is 0.11. The polymer composition of claim 9 , wherein X and R are independently selected from the group consisting of hydrogen claim 9 , linear alkyl claim 9 , alkenyl or alkynyl hydrocarbon chains claim 9 , and linear siloxanes.12. The polymer composition of claim 1 , wherein the linear ultraviolet radiation absorbing polyether is a reaction product of the ring opening polymerization of a monomer selected from a group consisting of ethylene oxide claim 1 , propylene oxide claim 1 , and a glycidyl ether.13. The polymer composition of claim 12 , wherein the glycidyl ether is selected from the group consisting of n-butyl glycidyl ether and 2-ethylhexylglycidyl ether.14. The polymer composition of claim 1 , wherein the UV-chromophore is selected from the group consisting of triazoles claim 1 , camphors claim 1 , dibenzoylmethanes claim 1 , 4-aminobenzoic acid and alkane esters thereof claim 1 , anthranilic acid and alkane esters thereof claim 1 , salicylic acid and alkane esters thereof ...

Подробнее

Номер записи: 62

30-01-2014 дата публикации

Perfluoroether sealant compositions

Номер: US20140027057A1

Автор: Chandra Rao, Juexiao Cai, Renhe Lin

Принадлежит: PRC Desoto International Inc

Disclosed are perfluoroethers and perfluoroether compositions useful in high temperature aerospace applications. The perfluoroethers can be adapted for use with various curing chemistries.

Подробнее

Номер записи: 63

06-02-2014 дата публикации

CURABLE COMPOSITION AND METHODS FOR IMPROVING RECOVERY PROPERTIES AND CREEP PROPERTIES

Номер: US20140039133A1

Автор: ANDO Hiroshi, Ito Hiroshi, Okamoto Toshihiko, Wakabayashi Katsuyu

Принадлежит: KANEKA CORPORATION

Disclosed are a curable composition characterized by using a curable composition including an organic polymer (A1) having one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds in which the one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds are silicon-containing functional groups each having three or more hydrolyzable groups on one or more silicon atoms thereof; and a method for controlling the recovery properties, durability and creep resistance of the cured article. Herewith, the present invention provides a curable composition capable of giving a cured article excellent in recovery properties, durability and creep resistance, and a method for controlling the recovery properties, durability and creep resistance of the cured article. 1. A curable composition comprising:an organic polymer (A1) having one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds in which the one or more silicon-containing functional groups capable of cross-linking by forming siloxane bonds are silicon-containing functional groups each having three or more hydrolyzable groups on one or more silicon atoms thereof, and a main chain skeleton of the organic polymer (A1) is a polyoxyalkylene polymer; andat least one silanol condensation catalyst selected from the group consisting of a tin carboxylate (C), an organotin catalyst (D), and a non-tin catalyst (E),wherein the curable composition further comprises any one of the following features (1) to (7):(1) the curable composition further comprises a microballoon (F);(2) the proportion of the organic polymer (A1) in the total amount of the curable composition is 5 to 28 wt %;(3) the curable composition further comprises an epoxy resin (I); {'br': None, 'sup': '1', 'sub': '3', '—Si(OR)\u2003\u2003(2)'}, '(4) the organic polymer (A1) is an organic polymer (A2) having one or more silicon-containing functional ...

Подробнее

Номер записи: 64

06-02-2014 дата публикации

TAGGED POLYMERS AND METHODS OF USE

Номер: US20140039147A1

Автор: CARLSON William Brendan, Casasanta, III Vincenzo, Phelan Gregory David

Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

A polymer includes a monomeric repeat unit represented by Formula I: 5. The polymer of claim 1 , wherein Ris a tag claim 1 , a chromophore claim 1 , or fluorophore claim 1 , or wherein Rcontains a radioisotope.8. The polymer of claim 6 , wherein R claim 6 , R claim 6 , Rand Rare H.9. The polymer of claim 6 , wherein L is —CHCH—.10. The polymer of claim 6 , wherein Y is absent.11. The polymer of claim 6 , wherein Y is C(O).12. The polymer of claim 6 , wherein Y is —(C-Calkyl)-N(C-Calkyl)-.13. The polymer of claim 12 , wherein Y is —CHCH—N(CHCH)—.14. The polymer of claim 6 , wherein Ris alkyl.15. The polymer of claim 14 , wherein Ris CH.1620-. (canceled)24. The polymer of claim 6 , wherein Ris halo.2533-. (canceled)3546-. (canceled) The present technology relates to polymers that can be tagged and tracked and to articles that are made from such polymers.The following description is provided to assist the understanding of the reader. None of the information provided or references cited is admitted to be prior art to the present technology.Environmental contamination by epoxy resins and bisphenol A, the primary component of most epoxy resins, is an increasing problem. However, the full measure of this problem remains unknown. Epoxy resins are increasingly used to make moldable plastics and numerous consumer products including toys and electronics. Epoxy resins are also incorporated into more substantial goods such as airplane fuselages. Most epoxy resins are made from bisphenol A which is itself produced from the condensation of acetone and phenol. Consequently, the epoxy resins from discarded products that accumulate in landfills can leach bisphenol A, phenol, and other toxins into groundwater and contaminate drinking supplies. There is an increasing need to prevent such environmental accumulation of epoxy resins and bisphenol A.At present, the extent of environmental contamination by epoxy resins and bisphenol A is unknown because there is not a convenient and ...

Подробнее

Номер записи: 65

06-02-2014 дата публикации

POLY(ETHYLENEOXIDE) FUNCTIONALIZATION THROUGH ALKYLATION

Номер: US20140039152A1

Автор: Eitouni Hany Basam, Li Yan, Pratt Russell Clayton, Sivanandan Kulandaivelu

Принадлежит:

A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal amide base is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers. 1. A method of functionalizing a high molecular weight polymer (HMP-OH) comprising the steps of:a. dissolving the HMP-OH in a first solvent and reacting with a metal amide (MAd), to form a first solution;b. adding RX to the first solution to form a second solution;c. adding the second solution to a second solvent to form a third solution, wherein the second solvent is capable of dissolving the MAd, the RX, and any reaction byproducts from steps a and b; andd. precipitating HMP-O-R from the third solution.2. The method of wherein the HMP-OH has a molecular weight between about 1 and 500 Kg mol.3. The method of wherein the HMP-OH comprises hydroxyl groups.4. The method of wherein the HMP-OH is selected from the group consisting of poly(ethyleneoxide) claim 1 , poly(propyleneoxide) claim 1 , poly(tetrahydrofuran) claim 1 , α claim 1 , ω-dihydroxy poly(styrene) claim 1 , α claim 1 , ω-dihydroxy polybutylene claim 1 , α claim 1 , ω-dihydroxy polyisoprene claim 1 , poly(hydroxystyrene) claim 1 , poly(hydroxyethylacrylate) claim 1 , poly(hydroxymethylstyrene) claim 1 , and poly(vinylalcohol).5. The method of wherein the MAd is selected from the group consisting of lithium bis(trimethylsilylamides) claim 1 , sodium bis(trimethylsilylamides) claim 1 , and potassium bis(trimethylsilylamides).6. The method of wherein the first solvent is selected from the group consisting of THF claim 1 , DMF claim 1 , toluene claim 1 , DMSO claim 1 , cyclohexanone claim 1 , xylene claim 1 , benzene claim 1 , and combinations thereof.7. The method of wherein the RX is an alkyl halide and the alkyl halide comprises a functional group selected from the group consisting of photoactive groups ...

Подробнее

Номер записи: 66

06-02-2014 дата публикации

Alkyl ether compositions and methods of use

Номер: US20140039214A1

Автор: Gregory D. Phelan, William B. Carlson

Принадлежит: EMPIRE TECHNOLOGY DEVELOPMENT LLC

A polymer includes a linker represented by Formula I ([OR 1 OCH 2 OR 2 OCH 2 ] m ), where R 1 and R 2 are, independently, alkylene, alkenylene, arylene, heteroarylene, or alkylarylalkylene; and the polymer has a weight average molecular weight of about 500 g/mol to about 2,000,000 g/mol, and m is 1 to 1000.

Подробнее

Номер записи: 67

13-02-2014 дата публикации

EPOXY SYSTEMS AND AMINE POLYMER SYSTEMS AND METHODS FOR MAKING THE SAME

Номер: US20140046001A1

Автор: Corley Larry Steven, Elmore Jim D., Hite Jerry R.

Принадлежит: Momentive Specialty Chemicals Inc.

Compositions and methods for forming surfactants, aqueous dispersions, and curing agents are provided. In one aspect, the invention relates to improved epoxy functional surfactants prepared by reaction of an epoxy composition and an amidoamine composition formed from a blend of acid-terminated polyoxyalkylene polyols. The improved epoxy functional surfactants may be reacted with an excess of epoxy composition and water to result in an aqueous dispersion. The amidoamine composition may be a reaction mixture of a diamine compound and an acid terminated polyoxyalkylene composition formed from two or more polyoxyalkylene polyol compounds. The epoxy functional surfactant may be reacted with amine compounds to form a compound suitable as a curing agent. 1. A composition , comprising:an acid terminated polyoxyalkylene composition of two or more acid terminated polyoxyalkylene polyol compounds, wherein the acid terminated polyoxyalkylene composition has a polydispersity of 1.1 or greater and the two or more acid terminated polyoxyalkylene polyol compounds have from about 50% to about 100% of carboxylic end groups; anda diamine compound comprising a first amine substituent group of a primary amine substituent group and a second amine substituent group of a primary amine substituent group or a secondary amine substituent group.3. The composition of claim 2 , wherein the diamine compound is provided at a stoichiometric excess of amine substituent groups to carboxylic end groups of the acid terminated polyoxyalkylene composition.4. The composition of claim 2 , wherein the reactant product further comprises a monoepoxy compound.6. The composition of claim 5 , wherein the Rsubstituent group further comprises an end group selected from the group of a methyl group claim 5 , a hydroxyl group claim 5 , and combinations and subsets thereof claim 5 , and the Rsubstituent group further comprises an end group selected from the group of a methyl group claim 5 , a hydroxyl group claim 5 , ...

Подробнее

Номер записи: 68

27-02-2014 дата публикации

Use of block-copolymeric polyalkylene oxides as friction reducers in synthetic lubricants

Номер: US20140057819A1

Автор: Birgit Weinenkötter, Frank Schubert, Kirsten Schönemann, Peter Seidensticker, Rene Haensel, Thorsten Bartels

Принадлежит: Evonik Industries AG

The invention relates to the use of block copolymers containing at least a block of aromatic oxyalkylene groups and a block of nonaromatic oxyalkylene groups as friction-reducing additive and also compositions and lubricant formulations containing the block copolymers of the invention.

Подробнее

Номер записи: 69

27-02-2014 дата публикации

Pigment dispersion and method for preparing same

Номер: US20140058017A1

Автор: CHEN Liu, Jisheng ZHAO, Wenwen SUN, Xuelan WANG

Принадлежит: BOE Technology Group Co Ltd

A pigment dispersion and a method for preparing the same are provided. The pigment dispersion comprises the following components in the following mass percentage: 10%˜20% pigment, 1.5%˜12% dispersant, 0.75%˜7.5% binder resin, 58.5%˜87.3% solvent and 0.45%˜2% nonionic surfactant, based on the total mass of the pigment dispersion. The pigment dispersion is improved in stability, and is applicable to a colored filter.

Подробнее

Номер записи: 70

13-03-2014 дата публикации

Maleimidyl polymer derivatives

Номер: US20140073802A1

Автор: Antoni Kozlowski, J. Milton Harris, Samuel P. McManus

Принадлежит: Nektar Therapeutics

The present invention provides, among other things, compounds that include a water-soluble and non-peptidic polymer as well as a maleimidyl group. The compounds are useful as, among other things, polymeric reagents.

Подробнее

Номер записи: 71

20-03-2014 дата публикации

POLYMER COMPOUNDS HAVING COUPLED COMPONENTS

Номер: US20140080938A1

Автор: Winkelmann Felix

Принадлежит:

Intermediate products (compounds, semi-finished goods) for polymer materials having coupled components, to the polymer materials based on the intermediate products, and to the components to be manufactured therefrom. A method for producing intermediate products, polymer materials and components, and to the use thereof. 111-. (canceled)12. A method for producing intermediate products for polymeric materials or parts thereof with addition-components , comprising the steps of: distributing a free radical initiator on the addition-component , adding a thermoplastic polymer and initiating crosslinking by energetic impact , whereby the polymer-chains are cross-linked to the surface of the addition-component.13. The method for producing intermediate products for polymeric materials or parts thereof with addition-components according to claim 12 , wherein the free radical initiator is distributed in solution or as a fine dispersed suspension or dispersion or as a fine dispersed solid on the addition-component.14. The method for producing intermediate products for polymeric materials or parts thereof with addition-components according to claim 12 , wherein the addition-component is present in a finely divided state with a linear dimension of less than 4 mm in at least one dimension and/or in fibrous type.15. The method for producing intermediate products for polymeric materials or parts thereof with addition-components according to claim 12 , wherein the thermoplastic polymer is applied on the addition-component by extrusion compounding with a free radical initiator.16. The method for producing intermediate products for polymeric materials or parts thereof with addition-components according to claim 12 , wherein a coupling agent and the free radical initiator are used in a molar ratio of 100:1 to 1:100.17. The method for producing intermediate products for polymeric materials or parts thereof with addition-components according to claim 12 , wherein the addition-component is ...

Подробнее

Номер записи: 72

03-04-2014 дата публикации

Compositions for Grafting Fragrance Substances

Номер: US20140090182A1

Автор: Basile Ketrin Leka, Dente Stephen V., Harraka Julianne, Johnson Garry, Kesavan Purushothaman, Mukherjee Satyabrata, Ryan John, Thottathil Paul

Принадлежит: Robertet, Inc.

This disclosure relates to composition for grafting fragrance substances, as well as related articles, consumer products, and methods. 1. A composition , comprising:a fragrance;a coupling agent;a polymerizable prepolymer;a graft initiator; anda catalyst.2. The composition of claim 1 , wherein the coupling agent is a silane of formula (I):{'br': None, 'sub': 1', '2', '3', '4, 'Si—RRRR\u2003\u2003(I),'}{'sub': 1', '1', '10', '2', '10', '2', '3', '4', '1', '10', '1', '10', '6', '30, 'in which Ris C-Calkyl or C-Calkenyl, and each of R, R, and R, independently, is C-Calkyl, C-Calkoxy, or C-Caryl.'}3. The composition of claim 2 , wherein Ris vinyl and each of R claim 2 , R claim 2 , and Ris methoxy.4. The composition of claim 1 , wherein the composition comprises from 0.1 ppm to 5000 ppm of the coupling agent.5. The composition of claim 1 , wherein the polymerizable prepolymer comprises a polyalkylene prepolymer claim 1 , a urethane prepolymer claim 1 , an acrylic prepolymer claim 1 , an epoxy prepolymer claim 1 , a bisphenol A prepolymer claim 1 , a silicone prepolymer claim 1 , a polyester prepolymer claim 1 , a polyalkylene glycol prepolymer claim 1 , a polycarbodiimide prepolymer claim 1 , a polydiene prepolymer or a phenolic prepolymer.6. The composition of claim 5 , wherein the prepolymer comprises an isobutylene/butylene copolymer.7. The composition of claim 1 , wherein the composition comprises from 2 wt % to 50 wt % of the prepolymer.8. The composition of claim 1 , wherein the graft initiator comprises a salt of Ag claim 1 , Fe claim 1 , Co claim 1 , or Cu claim 1 , or a mixture thereof.9. The composition of claim 8 , wherein the graft initiator comprises silver perchlorate.10. The composition of claim 1 , wherein the composition comprises from 0.01 ppm to 10 ppm of the graft initiator.11. The composition of claim 1 , wherein the catalyst comprises a peroxide claim 1 , a peracid claim 1 , a perbenzoate claim 1 , a metabisulfite claim 1 , a persulfate claim 1 , or ...

Подробнее

Номер записи: 73

03-04-2014 дата публикации

Cladding material for construction

Номер: US20140093679A1

Автор: Toshihiko Okamoto

Принадлежит: Kaneka Corp

A building exterior material is made of a curable composition which has excellent water vapor permeability. The building exterior material comprises a building exterior substrate coated with a curable composition comprising an organic polymer (A) containing a silicon-containing group capable of being cross-linked by forming a siloxane bond, wherein the organic polymer (A) is a polyoxyalkylene polymer (A1) containing an oxyethylene repeating unit in a backbone skeleton, a weight of the oxyethylene repeating unit in the component (A1) being 1 to 80% by weight of the total weight of the component (A1), and/or a (meth)acrylate polymer (A2) containing an oxyethylene repeating unit at a side chain, a weight of the oxyethylene repeating unit in the component (A2) being 1 to 50% by weight of the total weight of the component (A2), and the curable composition is cured into a cured product having a thickness of 0.1 to 3.0 mm.

Подробнее

Номер записи: 74

04-01-2018 дата публикации

DEPOT FORMULATIONS

Номер: US20180000729A1

Автор: LIN WeiQi, Matsumoto Naoki, MUDUMBA Sreenivasu, OKABE Komei, Su Huey-Ching, TAMRAZ Wilma, YAMADA Kazuhito

Принадлежит:

Pharmaceutical compositions comprising an active pharmaceutical ingredient, a high viscosity liquid carrier material, a hydrophobic solvent, and a hydrophilic solvent are disclosed. Also disclosed are methods of manufacturing and using the compositions. The compositions are suitable for use, e.g., as depot formulations. 2. The composition of claim 1 , wherein the HVLCM is present in an amount ranging from about 0.1 wt % to about 50 wt % claim 1 , based on weight of the composition.3. The composition of claim 2 , wherein the HVLCM is present in an amount ranging from about 1 wt % to about 20 wt % claim 2 , based on weight of the composition.4. The composition of claim 2 , wherein the HVLCM is present in an amount ranging from about 0.1 wt % to about 10 wt % claim 2 , based on weight of the composition.5. The composition of claim 1 , wherein the HVLCM comprises sucrose acetate isobutyrate (SAIB).6. The composition of claim 1 , wherein the composition comprises from about 1 wt % to about 5 wt % of the active pharmaceutical ingredient claim 1 , based on weight of the composition.7. The composition of claim 1 , wherein the active pharmaceutical ingredient comprises sirolimus.8. The composition of claim 1 , wherein the first hydrophobic solvent is present in an amount ranging from about 10 wt % to about 95 wt % claim 1 , based on weight of the composition.9. The composition of claim 8 , wherein the first hydrophobic solvent is present in an amount ranging from about 30 wt % to about 60 wt % claim 8 , based on weight of the composition.10. The composition of claim 9 , wherein the first hydrophobic solvent is present in an amount ranging from about 35 wt % to about 45 wt % claim 9 , based on weight of the composition.11. The composition of wherein the first hydrophobic solvent is present in an amount ranging from about 80 wt % to about 95 wt % claim 8 , based on weight of the composition.12. The composition of wherein the first hydrophobic solvent comprises at least one of ...

Подробнее

Номер записи: 75

06-01-2022 дата публикации

Temperature-Insensitive Membrane Materials and Analyte Sensors Containing the Same

Номер: US20220002498A1

Автор: BOMMAKANTI Balasubrahmanya S., Hoss Udo, LATOUR John V., Le Phu, Ouyang Tianmei, SANDHU Gary, WALLIS Kevin

Принадлежит: ABBOTT DIABETES CARE INC.

Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains. 1. A polymeric membrane composition comprising:a polymer backbone comprising one or more side chains that comprise a heterocycle; andan amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.2. The polymeric membrane composition of claim 1 , wherein the polymer backbone comprises a polyvinylpyridine or a polyvinylimidazole.3. The polymeric membrane composition of claim 2 , wherein the polymer backbone comprises a copolymer of vinylpyridine and styrene.4. The polymeric membrane composition of claim 1 , wherein the amine-free polyether arm comprises at least one polyethylene oxide block and at least one polypropylene oxide block claim 1 , the amine-free polyether arm being bound to a heterocyclic or heteroaromatic nitrogen atom in a side chain of the polymer backbone.6. The polymeric membrane composition of claim 5 , wherein x ranges between about 8 and about 16 claim 5 , y ranges between about 10 and about 32 claim 5 , and z ranges between about 10 and about 20.7. The polymeric membrane composition of claim 5 , wherein x≤z.8. The polymeric membrane composition of claim 5 , wherein a ratio of (x+z):y is at least about 1.7:1.9. The polymeric membrane composition of claim 5 , wherein a ratio of (x+z):y ranges between about 1.7:1 and about ...

Подробнее

Номер записи: 76

04-01-2018 дата публикации

Formulations and carrier systems including farnesylthiosalicylic moieties

Номер: US20180000957A1

Автор: Song Li, XIANG Gao, Xiaolan Zhang, Yixian Huang

Принадлежит: University of Pittsburgh

A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.

Подробнее

Номер записи: 77

02-01-2020 дата публикации

HETEROBIFUNCTIONAL MONODISPERSED POLYETHYLENE GLYCOL AND CONJUGATE USING SAME

Номер: US20200000933A1

Автор: HAMURA Mika, TSUBUSAKI Takuma, YOSHIMURA Kohei

Принадлежит: NOF CORPORATION

A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: 2. The heterobifunctional monodispersed polyethylene glycol as claimed in claim 1 , wherein claim 1 , in the formula (1) claim 1 , Ais represented by —NHC(O)—(CH)— or —NHC(O)—(CH)-L-(CH)— claim 1 , and Bis represented by —(CH)— or —(CH)-L-(CH).3. The heterobifunctional monodispersed polyethylene glycol as claimed in claim 1 , wherein claim 1 , in the formula (1) claim 1 , Ais represented by —CH— or —CH-L-(CH)— claim 1 , and Bis represented by —CH— or —CH-L-(CH)—.4. The heterobifunctional monodispersed polyethylene glycol as claimed in claim 1 , wherein claim 1 , in the formula (1) claim 1 , Ais represented by —O—(CH)— or —O—(CH)-L-(CH)— claim 1 , and Bis represented by —CH— or —CH-L-(CH)—.5. The heterobifunctional monodispersed polyethylene glycol as claimed in claim 1 , wherein claim 1 , in the formula (1) claim 1 , Ais represented by —C(O)NH—(CH)— or —C(O)NH—(CH)-L-(CH)— claim 1 , and Bis represented by —CH— or —CH-L-(CH)—.6. The heterobifunctional monodispersed polyethylene glycol as claimed in claim 1 , wherein claim 1 , in the formula (1) claim 1 , Ais represented by —C(O)NH—(CH)— or —C(O)NH—(CH)-L-(CH)— claim 1 , and Bis represented by —C(O)NH—(CH)— or —C(O)NH—(CH)-L(CH)—. The present invention relates to a heterobifunctional monodispersed polyethylene glycol having two different chemically reactive functional groups. More particularly, it relates to a heterobifunctional monodispersed polyethylene glycol, which is used for modification of a biofunctional molecule, for example, a physiologically active protein, a peptide, an antibody, a nucleic acid or a low molecular weight drug, a drug carrier in a drug delivery system, a diagnostic material, a medical device or the like and which is particularly useful for modification of an antibody drug, and a ...

Подробнее

Номер записи: 78

02-01-2020 дата публикации

BLOCK COPOLYMERS AND USES THEREOF

Номер: US20200000936A1

Автор: "ONeil Conlin P.", Dixon James Brandon, Hubbell Jeffrey A., SWARTZ Melody, Velluto Diana

Принадлежит:

An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix. 146-. (canceled)47. A supramolecular structure comprising a (i) a block copolymer comprising a positively charged block , and (ii) a nucleic acid , wherein said supramolecular structure has a maximal diameter of 60 nm or less.48. The supramolecular structure of claim 47 , wherein said supramolecular structure is a molecule or a vesicle.49. The supramolecular structure of claim 47 , wherein said block copolymer further comprises a hydrophilic block or a hydrophobic block.50. The supramolecular structure of claim 49 , wherein said block copolymer further comprises a hydrophilic block and a hydrophobic block.51. The supramolecular structure of claim 47 , wherein said maximal diameter is 40 nm or less.52. The supramolecular structure of claim 47 , wherein said block copolymer comprises PEG-PPS-PEI.53. The supramolecular structure of claim 47 , wherein said nucleic acid comprises a single-stranded oligonucleotide claim 47 , a short interfering RNA claim 47 , an aptamer claim 47 , or plasmid DNA.54. A method of transfecting a cell with a nucleic acid comprising contacting said cell with the supramolecular structure of .55. A block copolymer comprising PEG-PPS-PEI.56. The block copolymer of claim 55 , wherein the PPS block and the PEI block are attached via a bond that is labile in an endosome.57. The block copolymer of claim 56 , wherein said bond comprises a disulfide bond ...

Подробнее

Номер записи: 79

03-01-2019 дата публикации

Carrier Nanoparticles And Related Compositions, Methods And Systems

Номер: US20190000990A1

Автор: Akinleye Alabi, Mark E. Davis

Принадлежит: California Institute of Technology CalTech

Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle and related compositions, methods and systems.

Подробнее

Номер записи: 80

07-01-2021 дата публикации

PROCESS AND SYSTEMS FOR OBTAINING 1,4-BUTANEDIOL FROM FERMENTATION BROTHS

Номер: US20210002195A1

Автор: Garikipati SVB Janardhan, Japs Michael, Sonico Ishmael M.

Принадлежит:

A process of purifying 1,4-butanediol (1,4-BDO) from a fermentation broth including separating solid materials, salts and water, and subjecting the resulting material to a two, three or four column distillation system, that can include a wiped film evaporator to produce a purified 1,4-butanediol. 1. A process of purifying 1 ,4-butanediol (1 ,4-BDO) comprising:(a) subjecting a crude 1,4-BDO mixture to a first column distillation procedure to remove materials with a boiling point lower than 1,4-BDO from the crude 1,4-BDO mixture to produce a first 1,4-BDO-containing product stream; and(b) subjecting the first 1,4-BDO-containing product stream to a second column distillation procedure to remove materials with boiling points higher than 1,4-BDO as a first high-boilers stream, to produce a purified 1,4-BDO product, wherein the purified 1,4-BDO product is collected from a side-draw of the second column distillation procedure.2. The process of claim 1 , further comprising (c) subjecting the first high-boilers stream to wiped-film evaporation (WFE) to produce a first WFE distillate and subjecting the first WFE distillate to step (b).3. The process of further comprising (d) subjecting the first 1 claim 1 ,4-BDO-containing product stream claim 1 , prior to performing step (b) claim 1 , to an intermediate column distillation procedure to remove materials with boiling points higher than 1 claim 1 ,4-BDO as a second high-boilers stream.4. The process of claim 3 , further comprising (c) subjecting the second high-boilers stream to wiped-film evaporation (WFE) producing a second WFE distillate and subjecting the second WFE distillate to step (d).5. The process of further comprising (e) treating the first 1 claim 3 ,4-BDO-containing product stream with a hydrogenation reaction prior to performing step (b).6. The process of further comprising (f) treating the purified 1 claim 1 ,4-BDO product with a hydrogenation reaction.7. The process of wherein the crude 1 claim 1 ,4-BDO mixture ...

Подробнее

Номер записи: 81

02-01-2020 дата публикации

FLUORINE-CONTAINING ETHER COMPOUND, LUBRICANT FOR MAGNETIC RECORDING MEDIUM, AND MAGNETIC RECORDING MEDIUM

Номер: US20200002258A1

Автор: FUKUMOTO Naoya, Ito Naoko, MIYASAKA Ryuuta, Murofushi Katsumi, SERI Michio, TOMITA Hiroyuki

Принадлежит: SHOWA DENKO K.K.

A fluorine-containing ether compound according to the present invention is a fluorine-containing ether compound represented by the following General Formula (1). 2. The fluorine-containing ether compound according to claim 1 ,wherein A in the General Formula (1) is a linking group having at least one polar group and having 1 to 20 carbon atoms.4. The fluorine-containing ether compound according to claim 1 ,wherein the number-average molecular weight is in a range of 1,000 to 10,000.11. A lubricant for a magnetic recording medium comprising the fluorine-containing ether compound according to .12. A magnetic recording medium in which at least a magnetic layer claim 1 , a protective layer claim 1 , and a lubricating layer are sequentially provided on a substrate claim 1 ,{'claim-ref': {'@idref': 'CLM-00011', 'claim 11'}, 'wherein the lubricating layer consists of the lubricant for a magnetic recording medium according to .'}13. The magnetic recording medium according to claim 12 ,wherein the average film thickness of the lubricating layer is 0.5 nm to 3 nm. The present invention relates to a fluorine-containing ether compound, a lubricant for a magnetic recording medium, and a magnetic recording medium.Priority is claimed on Japanese Patent Application No. 2017-039820, filed Mar. 2, 2017, the content of which is incorporated herein by reference.The development of magnetic recording media suitable for a high recording density has progressed in order to improve the recording density of magnetic recording and reproducing devices.In the related art, magnetic recording media are known that have a recording layer or the like laminated on a substrate for a magnetic recording medium, a protective layer made of carbon or the like formed on the recording layer, and a lubricating layer additionally formed on the protective layer. The protective layer protects information recorded in the recording layer and improves the slidability of a magnetic head. However, it is not possible ...

Подробнее

Номер записи: 82

07-01-2016 дата публикации

POLOXAMER COMPOSITION FREE OF LONG CIRCULATING MATERIAL AND METHODS FOR PRODUCTION AND USES THEREOF

Номер: US20160002401A1

Автор: BALASUBRAMANIAN Mannarsamy, EMANUELE R. Martin

Принадлежит:

Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions. 1. A long circulating material free (LCMF) poloxamer 188 , wherein:{'sub': 2', '2', 'a′', '3', '2', 'b', '2', '2', 'a, 'claim-text': [{'sub': 2', '4, 'each of a and a′ is an integer such that the percentage of the hydrophile (CHO) is between approximately 60% and 90% by weight of the total molecular weight of the copolymer;'}, 'a and a′ are the same or different;', {'sub': 3', '6, 'b is an integer such that the molecular weight of the hydrophobe (CHO) is between approximately 1,300 and 2,300 Daltons;'}, 'no more than 1.5% of the total components in the polymeric distribution of the co-polymer are low molecular weight components having an average molecular weight of less than 4,500 Daltons;', 'no more than 1.5% of the total components in the polymeric distribution of the co-polymer are high molecular weight components having an average molecular weight of greater than 13,000 Daltons;', 'the polydispersity value of the copolymer is less than approximately 1.07 or less than 1.07; and, 'the LCMF poloxamer 188 is a polyoxyethylene/polyoxypropylene copolymer that has the formula HO(CHCHO)—[CH(CH)CHO]—(CHCHO)H, whereinfollowing intravenous administration to a human subject, the circulating plasma half-life of any components not comprising the main peak in the distribution of copolymer is no more than 5.0-fold the circulating half-life of the main component in the distribution of the copolymer.2. The LCMF poloxamer of claim 1 , wherein all components comprising the polymeric distribution of the copolymer have a circulating half-life in the plasma of the subject that is no more than 4.0-fold claim 1 , or 3.0-fold ...

Подробнее

Номер записи: 83

05-01-2017 дата публикации

POLOXAMER COMPOSITION FREE OF LONG CIRCULATING MATERIAL AND METHODS FOR PRODUCTION AND USES THEREOF

Номер: US20170002141A1

Автор: BALASUBRAMANIAN Mannarsamy, EMANUELE R. Martin, SMITH Stewart V.

Принадлежит: MAST THERAPEUTICS, INC.

Provided herein are long circulating material free (LCMF) poloxamer compositions and uses thereof. In particular, provided are LCMF poloxamer 188 compositions and uses thereof. Also provided are supercritical fluid extraction (SFE) methods and high pressure (subcritical) methods for preparing poloxamer compositions, particularly the LCMF poloxamer compositions. 1. A long circulating material free (LCMF) poloxamer 188 , wherein:{'sub': 2', '2', 'a′', '3', '2', 'b', '2', '2', 'a, 'claim-text': [{'sub': 2', '4, 'each of a and a′ is an integer such that the percentage of the hydrophile (CHO) is between approximately 60% and 90% by weight of the total molecular weight of the copolymer;'}, 'a and a′ are the same or different;', {'sub': 3', '6, 'b is an integer such that the molecular weight of the hydrophobe (CHO) is between approximately 1,300 and 2,300 Daltons;'}, 'no more than 1.5% of the total components in the polymeric distribution of the co-polymer are low molecular weight components having an average molecular weight of less than 4,500 Daltons;', 'no more than 1.5% of the total components in the polymeric distribution of the co-polymer are high molecular weight components having an average molecular weight of greater than 13,000 Daltons;', 'the polydispersity value of the copolymer is less than approximately 1.07 or less than 1.07; and, 'the LCMF poloxamer 188 is a polyoxyethylene/polyoxypropylene copolymer that has the formula HO(CHCHO)—[CH(CH)CHO]—(CHCHO)H, whereinfollowing intravenous administration to a human subject, the circulating plasma half-life of any components not comprising the main peak in the distribution of copolymer is no more than 5.0-fold the circulating half-life of the main component in the distribution of the copolymer.2. The LCMF poloxamer of claim 1 , wherein all components comprising the polymeric distribution of the copolymer have a circulating half-life in the plasma of the subject that is no more than 4.0-fold claim 1 , or 3.0-fold ...

Подробнее

Номер записи: 84

04-01-2018 дата публикации

Lactam-functionalized polymer, compositions and applications thereof

Номер: US20180002480A1

Автор: Kelly A. BRUSH, Todd A. Brugel

Принадлежит: HERCULES LLC

A lactam-functionalized polymer is disclosed. The lactam-functionalized polymer includes lactam-functionalized polyacetal polyether, polyhemiaminal polyether or polyaminal polyether. The applications of the lactam-functionalized polymer are also disclosed.

Подробнее

Номер записи: 85

04-01-2018 дата публикации

POLY(ETHYLENE GLYCOL) METHACRYLATE MICROGELS, PREPARATION METHOD AND USES

Номер: US20180002493A1

Автор: BILLON Laurent, BOULARAS Mohamed, GOMBART Emilie, SAVE Maud, TRANCHANT Jean-Francois

Принадлежит:

The invention relates to poly(oligo(ethylene glycol) methacrylate) microgels, to the process for preparing same and the uses thereof in various fields of application such as optics, electronics, pharmacy and cosmetics. 113-. (canceled)14. Microgels obtainable via precipitation polymerization of at least three monomers in an aqueous phase , in the presence of a crosslinking agent , said monomers being:{'sub': '2', 'di(ethylene glycol) methyl ether methacrylate (M(EO)MA),'}{'sub': 'n', 'an oligo(ethylene glycol) methyl ether methacrylate (M(EO)MA) n being an integer ranging from 3 to 12,'}{'sub': 1', '2', '3', '4', '1', '2', '3', '4, 'sup': −', '+', '+, 'a monomer of formula CRR═CRRin which R, R, Rand Rrepresent a hydrogen, a halogen or a hydrocarbon group, on condition that at least one of the four groups comprises a —COOH or —COOMgroup, Mrepresenting a cation.'}15. The microgels according to claim 14 , wherein M(EO)MA represents 50 mol % to 90 mol % of the total number of moles of the three monomers claim 14 , M(EO)MA represents 10 mol % to 50 mol % of the total number of moles of the three monomers and the monomer of formula CRR═CRRrepresents 0.1 mol % to 20 mol % of the total number of moles of the three monomers.16. The microgels according to claim 14 , wherein the monomer of formula CRR═CRRis methacrylic acid.17. The microgels according to claim 14 , wherein the crosslinking agent is an oligo(ethylene glycol) diacrylate (OEGDA) comprising from 1 to 10 ethylene glycol units.18. The microgels according to claim 14 , wherein said microgels comprise metal or metal oxide nanoparticles.19. The microgels according to claim 14 , wherein said microgels comprise magnetic nanoparticles.20. The microgels according to claim 14 , wherein said microgels comprise a compound selected in the group consisting of pigments claim 14 , dyes and sunscreens.21. A process for preparing hybrid microgels claim 14 , said process comprising the steps of:preparing a first aqueous colloidal ...

Подробнее

Номер записи: 86

02-01-2020 дата публикации

PERFLUORO(POLY)ETHER GROUP-CONTAINING COMPOUND, AND SURFACE TREATMENT AGENT AND ARTICLE INCLUDING SAME

Номер: US20200002551A1

Автор: MITSUHASHI Hisashi, NAITOU Masato, NOMURA Takashi, NOSE Masatoshi, TAKANO Shinya, WATANABE Yuusuke

Принадлежит: DAIKIN INDUSTRIES, LTD.

A perfluoro(poly)ether group-containing silane compound represented by formula (1a) or formula (1b) (wherein the symbols are as defined in the description). 2. The perfluoro(poly)ether group-containing silane compound according to claim 1 , wherein X represents claim 1 , each independently at each occurrence claim 1 , a single bond claim 1 , or a di- to decavalent organic group having at least one selected from the group consisting of —CH— claim 1 , —CO— claim 1 , —NR— and —SO— claim 1 , and{'sup': '4', 'sub': '1-6', 'Rrepresents, each independently at each occurrence, a hydrogen atom, a phenyl group, or a Calkyl group.'}3. The perfluoro(poly)ether group-containing silane compound according to claim 1 , wherein X represents claim 1 , each independently at each occurrence claim 1 , a single bond claim 1 , or a di- to decavalent organic group having at least one selected from the group consisting of —CH— claim 1 , —CONR— claim 1 , —CONR—CH— claim 1 , —CH—CONR— claim 1 , —CO— claim 1 , —CO—CH— claim 1 , —CH—CO— claim 1 , —SONR— claim 1 , —SONR—CH— claim 1 , —CH—SONR— claim 1 , —SO— claim 1 , —SO—CH— claim 1 , and —CH—SO— claim 1 , and{'sup': '4', 'sub': '1-6', 'Rrepresents, each independently at each occurrence, a hydrogen atom, a phenyl group, or a Calkyl group.'}4. The perfluoro(poly)ether group-containing silane compound according to claim 1 , wherein X represents claim 1 , each independently at each occurrence claim 1 , a single bond claim 1 , an alkylene group having 1 to 6 carbon atoms claim 1 , —R—CH—R— claim 1 , —R—CONR—R— claim 1 , —R—CONR—CH—R— claim 1 , —R—CH—CONR—R— claim 1 , —R—CO—R— claim 1 , —R—CO—CH-R— claim 1 , —R—CH—CO—R— claim 1 , —R—SONR—R— claim 1 , —R—SONR—CH—R— claim 1 , —R—CH—SONR—R— claim 1 , —R—SO—R— claim 1 , —R—SO—CH—R— claim 1 , or —R—CH—SO—R— claim 1 ,{'sup': 51', '52, 'Rand Reach independently represent a single bond, or an alkylene group having 1 to 6 carbon atoms, and'}{'sup': '4', 'sub': '1-6', 'Rrepresents, each independently at each ...

Подробнее

Номер записи: 87

02-01-2020 дата публикации

FLUORINE-CONTAINING ACETOPHENONE DERIVATIVE, FLUROINE BASED ADDITIVE, CURABLE COMPOSITION INCLUDING SAME, AND CURED PRODUCT THEREOF

Номер: US20200002554A1

Автор: ASANO Yu, Miyamoto Masanori

Принадлежит:

The invention provides a fluorine-containing acetophenone derivative which is useful as an additive that can impart excellent antifouling properties and scratch resistance to the surface of a cured coating and that also offers high transparency of the coating; a fluoroadditive and an active energy ray curable composition which each include the above derivative; a cured product of the composition; and an article having a cured coating of the composition. Specifically, this object is achieved by using a fluorine-containing acetophenone derivative, typically represented by the structural formula below, that is obtained by introducing an acryloyl group into a poly(perfluoroalkylene ether) chain and thereafter introducing, using Michael addition reaction, an α-aminoacetophenone-based structural unit capable of generating radical species by photocleavage 4. A fluoroadditive comprising the fluorine-containing acetophenone derivative described in claim 1 , and a fluorinated surfactant other than the fluorine-containing acetophenone derivative.5. The fluoroadditive according to claim 4 , wherein the fluorinated surfactant is a compound (II) having a poly(perfluoroalkylene ether) chain and a polymerizable unsaturated group.6. The fluoroadditive according to claim 5 , wherein the compound (II) having a poly(perfluoroalkylene ether) chain and a polymerizable unsaturated group is a product of reaction of a copolymer from monomers essentially including a compound (II-1) which has a structural moiety including a poly(perfluoroalkylene ether) chain and claim 5 , at both terminals thereof claim 5 , a polymerizable unsaturated group claim 5 , and a polymerizable unsaturated monomer (II-2) having a reactive functional group (α) claim 5 , with a compound (II-3) having a polymerizable unsaturated group and a reactive functional group (β) that is reactive to the reactive functional group (α).8. A curable composition comprising the fluorine-containing acetophenone derivative described in ...

Подробнее

Номер записи: 88

02-01-2020 дата публикации

Silane compound containing perfluoro (poly ) ether group

Номер: US20200002567A1

Автор: Hisashi Mitsuhashi, Kaori Ozawa, Masato NAITOU, Masatoshi Nose, Peter Hupfield, Shinya Takano, Takashi Nomura, Yuusuke Watanabe

Принадлежит: Daikin Industries Ltd

A perfluoro(poly)ether group-containing silane compound represented by formula (A1), (A2), (B1) or (B2), wherein the symbols are as defined in the description. Also disclosed is a surface-treating agent including the silane compound, a pellet including the surface-treating agent and an article including a base material and a layer formed from the silane compound or surface-treating agent. (Rf-PFPE) α′ -X 1 —(SiR a k R b l R c m ) α (A1) (R c m R b l R a k Si) α —X 1 -PFPE-X 1 —(SiR a k R b l R c m ) α (A2) (Rf-PFPE) γ′ —X 2 —(CR d k2 R e l2 R f m2 R g n2 ) γ (B1) (R g n2 R f m2 R e l2 R d k2 C) γ —X 2 -PFPE-X 2 —(CR d k2 R e l2 R f m2 R g n2 ) γ (B2)

Подробнее

Номер записи: 89

03-01-2019 дата публикации

LIQUID COMPOSITION FOR A WATERPROOFING MEMBRANE

Номер: US20190002627A1

Автор: BECQUET Jeremy, MAYER Andre

Принадлежит: BOSTIK SA

The invention relates to a liquid bi-component composition comprising a silylated polymer having alkoxysilane functions, an epoxy resin, an amine catalyst for the epoxy and a catalyst for silanol condensation, and an adhesion promoter or a coupling agent. After crosslinking, the liquid composition according to the invention makes it possible to obtain a waterproofing membrane suitable for pedestrian and/or vehicle traffic. 3. The liquid composition as claimed in claim 1 , wherein the catalyst (A2-1) comprises at least one phenolic ring substituted by at least two —(CH)—N(CH)functions claim 1 , these two —(CH)—N(CH)functions preferably being in the ortho position to the OH group.5. The liquid composition as claimed in claim 1 , wherein the catalyst (A2-2) different from the catalyst (A2-1) is chosen from the aromatic compounds comprising at least one hydroxyl function or at least one —(CH)—N(CH)function.7. The liquid composition as claimed in claim 1 , wherein the catalyst (A2) comprises a mixture of 2 claim 1 ,4 claim 1 ,6-tri(dimethylaminomethyl)phenol as catalyst (A2-1) and of dimethylbenzylamine as catalyst (A2-2).9. The liquid composition as claimed in claim 1 , wherein the epoxy resin (B1) is derived from diglycidyl ether claim 1 , preferably a derivative of bisphenol A diglycidyl ether.10. The liquid composition as claimed in claim 1 , wherein the coupling agent (A3) is a bifunctional compound comprising at least one first function capable of reacting with the silylated polymer (A1) and one second function capable of reacting with the epoxy resin (B1).11. A ready-to-use kit comprising the liquid composition as claimed in claim 1 , the compositions A and B being packaged in two separate compartments.12. The use of the liquid composition as claimed in claim 1 , or of the kit as claimed in for the formation of a waterproofing membrane.13. A waterproofing membrane obtained by crosslinking the liquid composition as claimed in .14. A process for waterproofing a ...

Подробнее

Номер записи: 90

03-01-2019 дата публикации

Functionalized (poly)alkoxylated (per)fluoropolyether polymers

Номер: US20190002633A1

Автор: Giovanni Simeone, Pier Antonio Guarda, Silvia Rita Petricci

Принадлежит: Solvay Specialty Polymers Italy SpA

The present invention relates to novel derivatives of (poly)alkoxylated (per)fluoropolyethers, also referred to as PFPE-PAGs, comprising unsaturated end groups bearing acrylate, allylic or vinylic moieties.

Подробнее

Номер записи: 91

03-01-2019 дата публикации

PROCESS FOR THE PREPARATION OF POLYETHER POLYOLS

Номер: US20190002634A1

Автор: Hofmann Jörg, Klesczewski Bert, Schneider Michael

Принадлежит:

The invention relates to a method for producing polyether carbonate polyols, wherein (i) in a first step a polyether carbonate polyol is produced from one or more H-functional starter substances, one or more alkylene oxides, and carbon dioxide in the presence of at least one DMC catalyst, and (ii) in a second step the polyether carbonate polyol is chain-extended with a mixture of at least two different alkylene oxides in the presence of at least one DMC catalyst. The invention further relates to polyether carbonate polyols that contain a terminal mixed block of at least two alkylene oxides and to a method for producing soft polyurethane foams, wherein a polyol component containing a polyether carbonate polyol according to the invention is used. 115-. (canceled)16. A process for the preparation of a polyethercarbonate polyol , comprising(i) preparing, in a first step, a polyethercarbonate polyol chain from one or more H-functional starter substances, one or more alkylene oxides and carbon dioxide in the presence of at least one DMC catalyst, and(ii) extending, in a second step, the polyethercarbonate polyol chain with a mixture of at least two different alkylene oxides in the presence of at least one DMC catalyst,and in that the mixture of at least two different alkylene oxides in the second step (ii) is a mixture comprising propylene oxide (PO) and ethylene oxide (EO) in a molar ratio PO/EO of 15/85 to 60/40.17. The process according to claim 16 , wherein claim 16 , in the first step (i) claim 16 ,(α) the H-functional starter substance or a mixture of at least two H-functional starter substances is taken and optionally water and/or other highly volatile compounds are removed by raising the temperature and/or reducing the pressure (“drying”), the DMC catalyst being added to the H-functional starter substance or the mixture of at least two H-functional starter substances before or after drying,{'sub': '2', '(β) for activation, a fraction, based on the total amount of ...

Подробнее

Номер записи: 92

03-01-2019 дата публикации

SILANE COMPOUND CONTAINING PERFLUORO(POLY)ETHER GROUP

Номер: US20190002635A1

Автор: MITSUHASHI Hisashi, NAMIKAWA Takashi, NOMURA Takashi, TAKANO Mayuko

Принадлежит: DAIKIN INDUSTRIES, LTD.

The present invention provides a perfluoro(poly)ether group containing silane compound of 2. (canceled)3. The perfluoro(poly)ether group containing silane compound according to wherein Rf is a perfluoroalkyl group having 1-16 carbon atoms.5. (canceled)6. (canceled)8. (canceled)9. (canceled)10. (canceled)11. The perfluoro(poly)ether group containing silane compound according to wherein an average molecular weight of the Rf-PFPE moiety is 500-30 claim 1 ,000.12. The perfluoro(poly)ether group containing silane compound according to having an average molecular weight of 2 claim 1 ,000-32 claim 1 ,000.13. A surface-treating agent comprising at least one perfluoro(poly)ether group containing silane compound of the formula (1a) according to .14. The surface-treating agent according to further comprising one or more components selected form a fluorine-containing oil claim 13 , a silicone oil and a catalyst.17. The surface-treating agent according to comprising at least one compound of the formula (3b).18. The surface-treating agent according to wherein a mass ratio of the perfluoro(poly)ether group containing silane compound of the formula (1a) and the compound of the formula (3b) is 4:1-1:4.19. The surface-treating agent according to wherein the compound of the formula (3a) has a number average molecular weight of 2 claim 16 ,000-8 claim 16 ,000.20. The surface-treating agent according to wherein the compound of the formula (3b) has a number average molecular weight of 2 claim 16 ,000-30 claim 16 ,000.21. The surface-treating agent according to wherein the compound of the formula (3b) has a number average molecular weight of 8 claim 16 ,000-30 claim 16 ,000.22. The surface-treating agent according to further comprising a solvent.23. The surface-treating agent according to which is used as an antifouling-coating agent or a water-proof coating agent.24. The surface-treating agent according to for vacuum deposition.25. A pellet containing the surface-treating agent according ...

Подробнее

Номер записи: 93

03-01-2019 дата публикации

POLYPHENYLENE ETHER AND RESIN COMPOSITION

Номер: US20190002637A1

Автор: Mitsui Akira, ORIMO Chihiro, YAMAGUCHI Toru, Yamamoto Mihoko

Принадлежит: ASAHI KASEI KABUSHIKI KAISHA

Provided is a polyphenylene ether resin composition having excellent heat aging resistance and fluidity. A polyphenylene ether includes at least one structural unit selected from chemical formulae (1), (2), and (3). 3. The polyphenylene ether according to claim 1 , wherein0.01 structural units to 10.0 structural units selected from the group consisting of chemical formulae (1), (2), and (3) are included per 100 monomer units forming the polyphenylene ether.4. The polyphenylene ether according to claim 1 , whereina ratio of structural units represented by chemical formula (1) relative to structural units represented by chemical formula (2) is 0 mol % to 30 mol %.5. The polyphenylene ether according to claim 1 , comprising:either or both of a structural unit represented by chemical formula (1) and a structural unit represented by chemical formula (2); anda structural unit represented by chemical formula (3).68-. (canceled)9. The polyphenylene ether according to claim 2 , wherein0.01 structural units to 10.0 structural units selected from the group consisting of chemical formulae (1), (2), and (3) are included per 100 monomer units forming the polyphenylene ether.10. The polyphenylene ether according to claim 2 , whereina ratio of structural units represented by chemical formula (1) relative to structural units represented by chemical formula (2) is 0 mol % to 30 mol %.11. The polyphenylene ether according to claim 3 , whereina ratio of structural units represented by chemical formula (1) relative to structural units represented by chemical formula (2) is 0 mol % to 30 mol %.12. The polyphenylene ether according to claim 2 , comprising:either or both of a structural unit represented by chemical formula (1) and a structural unit represented by chemical formula (2); anda structural unit represented by chemical formula (3).13. The polyphenylene ether according to claim 3 , comprising:either or both of a structural unit represented by chemical formula (1) and a structural ...

Подробнее

Номер записи: 94

13-01-2022 дата публикации

PERFLUOROPOLYETHER-BASED RUBBER COMPOSITION, CURED OBJECT OBTAINED THEREFROM, AND PRODUCT INCLUDING SAME

Номер: US20220010061A1

Автор: FUKUDA Kenichi, HAYASHI Ryuto

Принадлежит: SHIN-ETSU CHEMICAL CO., LTD.

A perfluoropolyether-based rubber composition which gives cured objects excellent in terms of heat resistance, low-temperature resistance, organic-solvent resistance, and acid resistance, the rubber composition being characterized by comprising (a) a linear perfluoropolyether compound having a number-average molecular weight of 1,000-100,000 and including at least two azido groups in the molecule and a divalent perfluoroalkyl ether structure in the main chain and (b) a linear perfluoropolyether compound having at least three ethynyl groups in the molecule. 1. A perfluoropolyether-based rubber composition comprising:(a) a linear perfluoropolyether compound containing at least two azide groups per molecule and a divalent perfluoroalkylether structure in its main chain, and having a number average molecular weight of 1,000 to 100,000 and(b) a linear perfluoropolyether compound containing at least three ethynyl groups per molecule.6. The perfluoropolyether-based rubber composition of which is heat curable.7. The perfluoropolyether-based rubber composition of claim 1 , further comprising (c) a transition metal catalyst.8. The perfluoropolyether-based rubber composition of which is room temperature curable.9. A perfluoropolyether-based rubber cured product which is formed by curing the perfluoropolyether-based rubber composition of .10. An article comprising the cured product of .11. The article of which is a rubber part for use in an automobile claim 10 , chemical plant claim 10 , inkjet printer claim 10 , semiconductor manufacturing line claim 10 , analytical or scientific instrument claim 10 , medical equipment claim 10 , residential environment or aircraft. This invention relates to a perfluoropolyether-based rubber composition comprising a linear perfluoropolyether compound containing at least two azide groups per molecule and a linear perfluoropolyether compound containing at least three ethynyl (—C≡C—H) groups per molecule, and a cured product thereof. More ...

Подробнее

Номер записи: 95

13-01-2022 дата публикации

FLUOROPOLYETHER GROUP-INCLUDING COMPOUND

Номер: US20220010063A1

Автор: MAEHIRA Takeshi, MITSUHASHI Hisashi, Motonari Yoshimi, Yamashita Tsuneo

Принадлежит: DAIKIN INDUSTRIES, LTD.

A fluoropolyether group-containing compound of formula (1) or (2): 2. The fluoropolyether group-containing compound according to claim 1 , wherein p1 is 0 claim 1 , and q1 is 2 or 3.3. The fluoropolyether group-containing compound according to claim 1 , wherein Ris a fluorine atom.4. The fluoropolyether group-containing compound according to claim 1 , wherein Xis each independently at each occurrence a divalent organic group.5. The fluoropolyether group-containing compound according to claim 1 , wherein Xis each independently at each occurrence —(Z)—(X)—(Z)—{'sup': 21', '22, 'wherein Zand Zare a divalent organic group;'}{'sup': '2', 'Xis an oxygen atom;'}z11 is 0 or 1;z12 is 0 or 1;z13 is 0 or 1; andat least one of z11 and z13 is 1.6. The fluoropolyether group-containing compound according to claim 1 , wherein Xis each independently at each occurrence an alkylene group. This application is a Rule 53(b) Continuation of International Application No. PCT/JP2020/013783 filed Mar. 26, 2020, claiming priority based on Japanese Patent Application No. 2019-066338 filed Mar. 29, 2019, the respective disclosures of which are incorporated herein by reference in their entirety.The present disclosure relates to a fluoropolyether group-containing compound.Certain types of fluorine-containing silane compounds are known to be capable of providing excellent water-repellency, oil-repellency, antifouling properties, and the like when used in surface treatment of a substrate. A layer obtained from a surface-treating agent containing a fluorine-containing silane compound (hereinafter, also referred to as a “surface-treating layer”) is applied as a so-called functional thin film to a large variety of substrates such as glass, plastics, fibers, and building materials.A known such fluorine-containing compound is a fluoropolyether group-containing silane compound having a fluoropolyether group in the molecular backbone and a hydrolyzable group bonding to a Si atom at the molecular terminal ...

Подробнее

Номер записи: 96

13-01-2022 дата публикации

ANTI-STAINING RESIN, ANTI-STAINING FABRIC AND FABRICATING METHOD THEREOF

Номер: US20220010484A1

Автор: HSU Chen-Shou, JUAN Sun-Wen, Lin Chun-Hung

Принадлежит:

An anti-staining fabric includes a base cloth and an anti-staining resin. The anti-staining resin is disposed on the base cloth, in which a method of fabricating the anti-staining resin includes the following steps. A first thermal process is performed to mix a polyol, a cross-linking agent, and a choline to form a first mixture, in which a reaction temperature of the first thermal process is between 90° C. and 120° C. A second thermal process is performed to mix the first mixture and a chain extender to form the anti-staining resin, in which the chain extender includes a first reagent and a second reagent, and a reaction temperature of the second thermal process is between 120° C. and 150° C. 1. An anti-staining fabric , comprising:a base cloth; performing a first thermal process to mix a polyol, a cross-linking agent, and a choline, such that a first mixture is formed, wherein a reaction temperature of the first thermal process is between 90° C. and 120° C.; and', 'performing a second thermal process to mix the first mixture and a chain extender, such that the anti-staining resin is formed, wherein the chain extender comprises a first reagent and a second reagent, and a reaction temperature of the second thermal process is between 120° C. and 150° C., 'an anti-staining resin disposed on the base cloth, wherein a fabricating method of the anti-staining resin comprises2. The anti-staining fabric of claim 1 , wherein the cross-linking agent and the second reagent have a same molecular structure.4. The anti-staining fabric of claim 1 , wherein the base cloth has a plurality of yarns interwoven with each other claim 1 , and the anti-staining resin wraps each of the yarns.5. The anti-staining fabric of claim 1 , wherein the base cloth has at least two layers claim 1 , and the anti-staining resin is disposed between the two layers of the base cloth.6. A fabricating method of an anti-staining resin claim 1 , comprising:performing a first thermal process to mix a polyol, a ...

Подробнее

Номер записи: 97

13-01-2022 дата публикации

Dendrite-Free, Wide Temperature Range Lithium Metal Batteries Enabled by Hybrid Network Ionic Liquids

Номер: US20220013807A1

Автор: Li Christopher, Li Xiaowei, Zheng Yongwei

Принадлежит:

Ionic liquid N-methyl-N-propyl-pyrrolidinium bis(fluorosulfonyl)imide (PyrFSI) was introduced into a hybrid network to obtain a series of gel polymer electrolytes (GPEs). Mechanical and electrochemical properties of the GPEs were tuned through controlling the network structure and ionic liquid contents, and ionic conductivity higher than 1 mS cmat room temperature was achieved. The newly developed GPEs are flame-retardant and show excellent thermal and electrochemical stability as well as ultra-stability with lithium metal anode. Symmetrical lithium cells with the GPEs exhibit a stable cycling over 6800 h at a current density of 0.1 mA cmand stable lithium stripping-plating at 1 mA cm, the highest current density reported for ionic liquid-based GPEs. Moreover, Li/LiFePObatteries with the obtained GPEs exhibit desirable cycling stability and rate performance over a wide temperature range from 0° C. to 90° C. 1. A lithium gel polymer electrolyte composition comprising a crosslinked network , an ionic liquid , and one or more lithium salts , wherein the crosslinked network is formed by reacting an inorganic polyhedral oligomeric silsesquioxane with a functionalized poly(ethylene glycol) or functionalized poly(ethylene oxide).2. The composition of claim 1 , wherein the polyhedral oligomeric silsesquioxane is reacted with an amine-terminated diterminal functionalized poly(ethylene glycol).3. The composition of claim 1 , wherein the polyhedral oligomeric silsesquioxane is reacted with an amine-terminated diterminal functionalized (polyethylene oxide).5. The composition of claim 1 , wherein inorganic polyhedral oligomeric silsesquioxane is selected from octakis(3-glycidyloxypropyldimethylsiloxy)octasilsesquioxane claim 1 , epoxycyclohexylethyl polysilsesquioxane claim 1 , glycidyl polyhedral oligomeric silsesquioxane claim 1 , and octa epoxycyclohexyldimethylsilyl polyhedral oligomeric silsesquioxane.6. The composition of claim 1 , where the inorganic polyhedral oligomeric ...

Подробнее

Номер записи: 98

02-01-2020 дата публикации

LUBRICANT FOR MAGNETIC RECORDING MEDIUM, AND METHOD FOR PRODUCING MAGNETIC RECORDING MEDIUM

Номер: US20200005824A1

Автор: FUKUMOTO Naoya, HATTORI Hiroko, Ito Naoko, MIYASAKA Ryuuta, Murofushi Katsumi, OTA Ichiro, TOMITA Hiroyuki

Принадлежит: SHOWA DENKO K.K.

A lubricant for a magnetic recording medium capable of forming a lubricant layer having excellent adhesion to a protective layer is provided. A lubricant for a magnetic recording medium contains a fluorine-containing ether compound in which a group having an ethylenic carbon-carbon double bond is disposed at one or both terminals of a perfluoroalkyl polyether chain. It is preferable that the group having the ethylenic carbon-carbon double bond is disposed at one terminal of the perfluoroalkyl polyether chain, and a hydroxyl group is disposed at other terminal. It is preferable that the lubricant for a magnetic recording medium contains a compound in which one or more functional groups selected from a hydroxyl group, an amino group, an amido group and a carboxyl group is disposed at one or both terminals of a perfluoroalkyl polyether chain. 1. A lubricant for a magnetic recording medium , comprising a fluorine-containing ether compound in which a group having an ethylenic carbon-carbon double bond is disposed at one or both terminals of a perfluoroalkyl polyether chain.2. The lubricant for a magnetic recording medium according to claim 1 , wherein the group having the ethylenic carbon-carbon double bond is disposed at one terminal of the perfluoroalkyl polyether chain and a hydroxyl group is disposed at the other terminal.3. The lubricant for a magnetic recording medium according to claim 1 ,wherein the group having an ethylenic carbon-carbon double bond is a (meth)acryloyl group.4. The lubricant for a magnetic recording medium according to claim 1 ,wherein the group having an ethylenic carbon-carbon double bond is a (meth)acryloyloxy group.10. The lubricant for a magnetic recording medium according to claim 1 ,further comprising a second compound in which one or more functional groups which are one or more types selected from the group consisting of a hydroxyl group, an amino group, an amido group and a carboxyl group are disposed at one or both terminals of a ...

Подробнее

Номер записи: 99

20-01-2022 дата публикации

ANISOTROPIC COPOLY(IMIDE OXETANE) COATINGS AND ARTICLES OF MANUFACTURE, COPOLY(IMIDE OXETANE)S CONTAINING PENDANT FLUOROCARBON MOIETIES, OLIGOMERS AND PROCESSES THEREFOR

Номер: US20220017479A1

Автор: Connell John W., JR. Christopher J., JR. Joseph G., Siochi Emilie J., Smith, Wohl

Принадлежит:

Copoly(imide oxetane) materials are disclosed that can exhibit a low surface energy while possessing the mechanical, thermal, chemical and optical properties associated with polyimides. The copoly(imide oxetane)s are prepared using a minor amount of fluorinated oxetane-derived oligomer with sufficient fluorine-containing segments of the copoly(imide oxetane)s migrate to the exterior surface of the polymeric material to yield low surface energies. Thus the coatings and articles of manufacture made with the copoly(imide oxetane)s of this invention are characterized as having an anisotropic fluorine composition. The low surface energies can be achieved with very low content of fluorinated oxetane-derived oligomer. The copolymers of this invention can enhance the viability of polyimides for many applications and may be acceptable where homopolyimide materials have been unacceptable. 2. A polymer composite comprising a copolymer containing the copoly(amide acid oxetane) of and particulate filler to provide a water contact angle of at least 100°.3. A process for making a copoly(amic oxetane) of comprising: [{'br': None, 'H—O-J-H'}, 'wherein', {'sub': 2', '2', 'm', '2', '2', 'p', 'q', '2', '2', 'r, 'sup': 2', '3', '2', '3', '6', '2', '3', '6, 'J is [CH—CRR—CH—O]or [(CH—CRR—CH—O)—(R—O)—(CH—CRR—CH—O)] wherein Ris substituted or unsubstituted aliphatic or aromatic moiety of 2 to 16 carbons;'}, {'sup': '1', 'Ris aliphatic or aromatic hydrocarbon moiety of 1 to 10 carbon atoms;'}, {'sup': '2', 'Ris —H, —F, or alkyl of 1 to 6 carbon atoms;'}, {'sup': 3', '4', '5', '4', '4', '4', '5, 'sub': (n-a)', 'a', '(n-a)', 'a', '(n-a)', 'a, 'Ris —F, —RHF, —R—O—RHF, and —O—RHF, wherein Ris an alkyl or ether moiety of 1 to 30 carbons, Ris an alkyl moiety of 1 to 30 carbons, a is an integer of 3 to n, and n is twice the number of carbon atoms in the alkyl moiety plus 1; and'}, 'm is between about 4 and 500, p is between about 4 and 150, q is between about 1 and 150;, 'a. reacting an oxetane ...

Подробнее

Номер записи: 100