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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 7783. Отображено 100.
03-05-2012 дата публикации

Polymers and Hydrogels

Номер: US20120107369A1
Автор: Adrian S. Fox, Guoming Sun, Roy R. Yeoman, III
Принадлежит: nanoDERM LLC

Methods and compositions related polymers and hydrogels. In some cases to biodegradable hydrogels for use in medical applications are disclosed. The polymers and hydrogels may be produced from cross-linked dextran and poly(epoxides). The poly(epoxides) may be poloxamers.

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Номер записи: 1
24-05-2012 дата публикации

Modified hyaluronic acid polymer compositions and related methods

Номер: US20120128741A1
Автор: David M. Gravett, George Y. Daniloff, Pingren He
Принадлежит: Carbylan Biosurgery Inc

The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.

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Номер записи: 2
26-07-2012 дата публикации

Novel injectable chitosan mixtures forming hydrogels

Номер: US20120189704A1
Автор: Abraham Patchornik, Dror Robinson, Noah Ben-Shalom, Zvi Nevo
Принадлежит: Chi2Gel Ltd

A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

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Номер записи: 3
26-07-2012 дата публикации

Viscoelastic gels as novel fillers

Номер: US20120190644A1
Автор: Davide RENIER, Matteo D'este
Принадлежит: Fidia Farmaceutici SpA

Biomaterials obtainable by mixing the autocrosslinked derivative of hyaluronic acid (ACP) with the derivative (HBC) of hyaluronic acid crosslinked with 1,4-butanediol diglycidyl ether (BDDE) in the weight ratio of between 10:90 and 90:10 as novel fillers.

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Номер записи: 4
06-12-2012 дата публикации

Porous, low density nanoclay composite

Номер: US20120309245A1
Автор: Darin L. Dotson, Hao Zhou, Philip T. Wilson, Qi Liao, Walter A. Scrivens
Принадлежит: Individual

Disclosed are porous, low density nanoclay composites that exhibit highly homogeneous microcellular morphology and methods for forming the nanocomposites. The nanocomposites include a three-dimensional matrix having a non-lamellar, generally isotropic cellular structure with little or no macroscopic pores. The nanocomposites also include a gel that may be a noncovalently cross-linked, thermoreversible gel. The nanocomposites may include a binder and/or fibrous reinforcement materials. The nanocomposites may be formed according to a freeze-drying process in which ice crystal growth is controlled to prevent formation of macroscopic pores in the composite materials.

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Номер записи: 5
09-05-2013 дата публикации

Process for dry-grinding a polysaccharide derivative

Номер: US20130112787A1
Автор: Juergen Hermanns, Peter E. Pierini, Yvonne M. Goerlach-Doht
Принадлежит: Individual

In a process for producing a particulate polysaccharide derivative by dry-grinding a moist polysaccharide derivative, one or more of the properties selected from median diameter, median length, bulk density and dissolution rate is controlled by controlling the temperature of the polysaccharide derivative prior to thy-grinding. Advantageously one or more of the properties selected from median diameter, median length, bulk density and dissolution rate of the particles after thy-grinding is adjusted to a first value by a first temperature of the polysaccharide derivative prior to thy-grinding and is adjusted to a second value by a second temperature.

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Номер записи: 6
08-08-2013 дата публикации

Filler composition for tissue reinforcement

Номер: US20130203856A1
Автор: Byung Su Kim, Eui Jin Hwang, Eun Ju Oh, Il Hwan Cho, Jun Seok Yeom, Jung Kyu Park, Moo Seok Seo, Sei Kwang Hahn, Young Soo Park
Принадлежит: Academy Industry Foundation of POSTECH, Shin Poon Pharmaceutical Co Ltd

The present invention relates to a filler composition for tissue reinforcement, including hyaluronic acid and alkylene diamine crosslinked hydrogel. The filler composition exhibits the positive physical properties required for tissue reinforcement, such as biocompatibility and swelling ability, as well as useful effects in that the same can remain in vivo for a long time.

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Номер записи: 7
19-09-2013 дата публикации

Injectable chitosan mixtures forming hydrogels

Номер: US20130244972A1
Автор: Abraham Patchornik, Dror Robinson, Noah Ben-Shalom, Zvi Nevo
Принадлежит: MOR RESEARCH APPLICATIONS LTD

A chitosan composition which forms a hydrogel at near physiological pH and 37° C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37° C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

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Номер записи: 8
20-02-2014 дата публикации

Hemostatic compositions and therapeutic regimens

Номер: US20140051849A1
Автор: John N. Voumakls, Sergio Finkielsztein
Принадлежит: Marine Polymer Technologies Inc

The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes.

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Номер записи: 9
04-01-2018 дата публикации

Method for manufacturing medical material, medical material, and anti-adhesion material

Номер: US20180000994A1
Автор: Yasuharu Noishiki, Yasuyuki Isono
Принадлежит: Dainichiseika Color and Chemicals Mfg Co Ltd

There is provided a process for producing a medical, material that retains the properties which are inherent in a polyanionic polysaccharide being a raw material, that has a high level of safety because there is no need to use a chemical crosslinking agent, and that has moderate strength and flexibility. The present invention is a process for producing a medical material, the process including a step of dispersing a powder or a granular product of a first polyanionic polysaccharide, the first polyanionic polysaccharide water-insolubilized with a treatment liquid containing a first acid anhydride, in an aqueous solution of a water-soluble salt of a second polyanionic polysaccharide, thereby obtaining a dispersion liquid, a step of drying the dispersion liquid obtained, thereby obtaining a dried film, and a step of water-insolubilizing the dried film obtained with a treatment liquid containing a second acid anhydride, thereby obtaining the medical material.

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Номер записи: 10
07-01-2016 дата публикации

Formaldehyde-free melamine carbohydrate binders for improved fire- resistant fibrous materials

Номер: US20160002385A1
Автор: Kiarash Alavi
Принадлежит: JOHNS MANVILLE

Embodiments of the present technology include a formaldehyde-free binder composition. The composition may include melamine. The composition may also include a reducing sugar. In addition, the binder composition may include a non-carbohydrate aldehyde or ketone. Embodiments may also include a method of making a formaldehyde-free binder composition. The method may include dissolving melamine in an aqueous solution of a reducing sugar. The concentration of the reducing sugar may be 30 wt. % to 70 wt. % of the aqueous solution, which may be at a temperature of 50° C. to 100° C. The method may also include adding a non-carbohydrate aldehyde or ketone to the dissolved melamine in the aqueous solution to form a binder solution. The temperature of the aqueous solution of the dissolved melamine may be 50° C. to 100° C. during the addition of the non-carbohydrate aldehyde or ketone. The method may further include reducing the temperature of the binder solution.

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Номер записи: 11
05-01-2017 дата публикации

Methods for Purifying Polysaccharides and Pharmaceutical Compositions and Medical Devices Containing the Same

Номер: US20170002099A1
Автор: FORGET Aurelien, Shastri Venkatram Prasad, Vonwil Daniel
Принадлежит:

Methods for removing endotoxin from naturally occurring materials, such as polysaccharides (e.g., agarose and/or carrageenan) are described herein. Polysaccharides that are substantially free of endotoxins and uses thereof are also described. The polysaccharide materials can be isolated from microorganisms, multicellular organisms, such as, algae, plants, seaweed, etc. The method involves the use of acidic and basic solutions to hydrolyze the lipid-polysaccharide bond in endotoxins. Cleaving the fatty acid from the polysaccharide reduces the water-solubility of the fatty acid and enables its removal with an organic solvent such as ethanol. The polysaccharide component can also undergo acidic or basic hydrolysis due to the weak glycosidic bond between the sugar rings. 1. A method for isolating and purifying a naturally occurring agarose or derivative thereof produced from a biological source , the method comprising:(i) dispersing the agarose in one or more aliphatic alcohols to disrupt the bacterial wall to solubilize the lipid portion of endotoxins;(ii) removing the aliphatic alcohol to remove the lipid portion of the endotoxins and obtain the agarose or derivative thereof in solid form;(iii) dispersing the solid agarose or derivative thereof in a basic solution to hydrolyze lipid-inner core bonds of the endotoxins and solubilize the polysaccharide component of the endotoxins;(iv) washing the solution from step (iii) with an aliphatic alcohol to remove free lipids;(v) removing the basic solution in step (iii) to obtain the agarose or derivative thereof in solid form;(vi) dispersing the solid agarose or derivative thereof in an acidic solution to hydrolyze lipid-inner core bonds of the endotoxins not cleaved in step (iii);(vii) removing the acidic solution in step (vi) to obtain the agarose or derivative thereof in solid form;(viii) dispersing the solid agarose or derivative thereof from step (vii) in a second basic solution to further cleave lipid-inner core bonds ...

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Номер записи: 12
07-01-2016 дата публикации

LAMINATE FILM USING POLYLACTIC ACID-BASED RESIN

Номер: US20160002422A1
Автор: Goto Yuki, Hochi Motonori, Minomo Katsuhiro, TAMIMIYA Naomi
Принадлежит:

Our invention is a laminate film comprising a water-soluble resin layer and a polylactic acid-based resin layer laminated on at least one side of a substrate film, the water-soluble resin layer has a thickness of 0.1 to 15 μm, the polylactic acid-based resin layer has a thickness of 10 to 500 nm. Such a configuration provides a laminate film of which the water-soluble resin layer and the polylactic acid-based resin layer are easily separated from the substrate film and which is excellent in coating ability, adherence and followability to a soft and curved adherend, as well as compatibility to skin and organs such as viscera, so as to be suitable for wound dressing, adhesion prevention material and a skin external agent such as skin-care product. 1. A laminate film comprising a water-soluble resin layer and a polylactic acid-based resin layer laminated on at least one side of a substrate film , characterized in that the water-soluble resin layer has a thickness of 0.1 to 15 μm , the polylactic acid-based resin layer has a thickness of 10 to 500 nm.2. The laminate film according to claim 1 , wherein the water-soluble resin layer contains a polyvinyl alcohol.3. The laminated film according to claim 2 , wherein the polyvinyl alcohol has a saponification degree of 85 to 98.5 mol %.4. The laminate film according to claim 1 , wherein the polylactic acid-based resin layer contains a polylactic acid-based resin including a poly-D-lactic acid of 4 to 13 mol %.5. The laminate film according to claim 1 , wherein the water-soluble resin layer contains a pullulan.6. The laminate film according to claim 1 , wherein the substrate film has a center-line average surface roughness (SRa) of 3 to 50 nm and a ten-point average surface roughness (SRz) of 50 to 1000 nm. The present invention relates to a laminate film using a polylactic acid-based resin suitable for medical use such as wound dressing membrane and adhesion prevention membrane.Surgical operations typified by abdominal ...

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Номер записи: 13
04-01-2018 дата публикации

SUBTERRANEAN FLUIDS CONTAINING SUSPENDED POLYMER BODIES

Номер: US20180002596A1
Автор: Abivin Patrice, Busby Brent, Godoy-Vargas Jazmin, Makarychev-Mikhailov Sergey, Sullivan Philip
Принадлежит:

An aqueous suspension of polymer bodies is made by coalescing polymer from a flowing aqueous solution. These suspended bodies may be fibrous in appearance. However, the coalescence of the polymer bodies may be controlled to produce shapes. The coalesced polymer bodies are used for treating a downhole location within or accessed by a borehole. The bodies may be formed by coalescence at the surface and then pumped downhole or may be formed by coalescence downhole. Coalescence of polymer may result from crosslinking, complexing with material of opposite charge, or change in the polymer solution temperature, pH, solute concentration or solvent. The coalesced polymer bodies are maintained in aqueous solution after coalescence, and are not removed from solution for strengthening. 1. A method of treating a downhole location within or accessed by a borehole , the method comprising:coalescing polymer from a flowing aqueous polymer solution to generate an aqueous suspension of coalesced bodies of polymer, andproviding the aqueous suspension of coalesced bodies at the downhole location.2. The method according to claim 1 , wherein the coalesced polymer bodies are formed by coalescence of polymer at the surface and the aqueous suspension of bodies of polymer is delivered through at least one pump into the borehole claim 1 , wherein the pump is configured to convey the aqueous suspension of bodies of polymer downhole.3. The method according to claim 1 , wherein the aqueous polymer solution is delivered through at least one pump into the borehole and the coalesced polymer bodies of polymer are formed by coalescence of the polymer underground.4. The method according to claim 1 , wherein the coalescing the polymer is brought about by crosslinking polymer molecules to form the coalesced polymer bodies in the aqueous suspension of bodies of polymer.5. The method according to claim 1 , wherein the polymer comprises an ionic charge and the coalescing the polymer is brought about by ...

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Номер записи: 14
07-01-2021 дата публикации

BIOCOMPATIBLE HYDROGEL CAPSULES AND PROCESS FOR PREPARING SAME

Номер: US20210002433A1
Автор: Barney Lauren Emily, Heidebrecht Richard, Johnston Erika Ellen, Miller Robert James
Принадлежит:

Described herein are compositions and methods for preparing hydrogel capsules using a cross-linking solution comprising a process additive. The process additive improves the quality of the resulting hydrogel capsules, such as increasing the number of defect-free capsules. 117-. (canceled)18. A process for preparing a hydrogel capsule composition from a polymer solution which comprises at least one afibrotic hydrogel-forming polymer and optionally an unmodified hydrogel-forming polymer , the process comprising contacting a plurality of droplets of the polymer solution with an aqueous cross-linking solution for a period of time sufficient to produce hydrogel capsules , wherein the cross-linking solution comprises a cross-linking agent , a buffer , an osmolarity-adjusting agent and a process additive , wherein the process additive is an amphiphilic compound.19. The process of claim 18 , wherein the polymer solution further comprises a cell suspension comprising a plurality of cells.20. The process of claim 19 , wherein the process additive reduces the surface tension of the cross-linking solution by about 1% claim 19 , about 2% claim 19 , about 5% claim 19 , about 10% claim 19 , about 15% claim 19 , about 20% claim 19 , about 25% claim 19 , about 30% claim 19 , about 35% claim 19 , about 40% claim 19 , about 45% claim 19 , about 50% claim 19 , or more.21. The process of claim 19 , wherein at least 95% of the hydrogel capsules in the hydrogel capsule composition are spherical capsules.22. The process of claim 19 , wherein the process additive is a surfactant or a non-ionic surfactant claim 19 , and the process additive is present in the cross-linking solution at a concentration of 0.001% to about 0.1% claim 19 , about 0.005% to about 0.05% claim 19 , about 0.005% to about 0.01% claim 19 , or about 0.01% to about 0.05%.23. The process of claim 22 , wherein the process additive is a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock ...

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Номер записи: 15
13-01-2022 дата публикации

GREEN METHOD TO PREPARE PLAIN WATER-BASED POLYSACCHARIDE CHITOSAN SOLUTIONS

Номер: US20220010076A1
Автор: LI Boxuan, Wang Juan, YANG Hu
Принадлежит: Virginia Commonwealth University

A method is provided for producing a composition comprising chitosan and water, comprising dissolving chitosan powder in an ionic liquid, to prepare a first composition comprising chitosan and ionic liquid; and contacting the first composition with water under conditions sufficient to solvent-exchange all or substantially all of the ionic liquid with water; to form a composition comprising chitosan and water. Compositions produced thereby and methods of using the compositions are provided. 1. A method for producing a composition comprising chitosan and water , comprising:dissolving chitosan powder in an ionic liquid, to prepare a first composition comprising chitosan and ionic liquid; andcontacting the first composition with water under conditions sufficient to solvent-exchange all or substantially all of the ionic liquid with water;to form a composition comprising chitosan and water.2. The method of claim 1 , further comprising claim 1 , after the dissolving and prior to the contacting claim 1 , freezing the first composition to form a frozen composition comprising chitosan and the ionic liquid claim 1 , wherein said contacting the first composition comprises contacting the frozen composition.3. The method of claim 1 , further comprising vortexing the composition comprising chitosan and water.4. The method of claim 1 , wherein the composition comprising chitosan and water comprises chitosan solutes having a size in the range of 1 to 1 claim 1 ,000 nm.5. The method of claim 1 , further comprising removing excess water from the composition comprising chitosan and water.6. The method of claim 1 , wherein the ionic liquid is hydrophilic.7. The method of claim 1 , wherein the ionic liquid is one or more of 1-allyl-3-methyl-imidazolium bromide; 1-allyl-3-methyl-imidazolium chloride; 1-butyl-3-methyl-imidazolium acetate; 1-butyl-3-methyl-imidazolium chloride; 1-ethyl-3-methyl-imidazolium acetate; 1-ethyl-3-methyl-imidazolium chloride; 1-ethyl-3-methyl-imidazolium dimethyl ...

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Номер записи: 16
13-01-2022 дата публикации

METHODS FOR SYNTHESIZING ANTICOAGULANT POLYSACCHARIDES

Номер: US20220010344A1
Автор: GESTEIRA Tarsis Ferreira, LAJINESS Daniel H.
Принадлежит:

The present invention includes methods for preparing anticoagulant polysaccharides using several non-naturally occurring, engineered sulfotransferase enzymes that are designed to react with aryl sulfate compounds instead of the natural substrate, PAPS, to facilitate sulfo group transfer to polysaccharide sulfo group acceptors. Suitable aryl sulfate compounds include, but are not limited to, p-nitrophenyl sulfate or 4-nitrocatechol sulfate. Anticoagulant polysaccharides produced by methods of the present invention comprise N-, 3-O-, 6-O-sulfated glucosamine residues and 2-O sulfated hexuronic acid residues, have comparable anticoagulant activity compared to commercially-available anticoagulant polysaccharides, and can be utilized to form truncated anticoagulant polysaccharides having a reduced molecular weight. 1. A method of enzymatically synthesizing an N- , 2-O , 3-O , 6-O sulfated , heparan sulfate (N ,2 ,3 ,6-HS) product in the absence of 3′-phosphoadenosine 5′-phosphosulfate (PAPS) , the method comprising the following steps:a. providing a starting polysaccharide mixture comprising N-sulfated heparosan;b. combining the starting polysaccharide mixture with a first sulfotransferase reaction mixture comprising a hexuronyl 2-O sulfotransferase enzyme (2OST) and a sulfo group donor, the sulfo group donor consisting of an aryl sulfate compound, to form a first product mixture, the first product mixture comprising an N-, 2-O sulfated heparan sulfate (N,2-HS) product;c. combining the first product mixture with a second sulfotransferase reaction mixture comprising a glucosaminyl 6-O sulfotransferase enzyme (6OST) and a sulfo group donor, the sulfo group donor consisting of an aryl sulfate compound, to form a second product mixture, the second product mixture comprising an N-, 2-O, 6-O sulfated heparan sulfate (N,2,6-HS) product;d. combining the second product mixture with a third sulfotransferase reaction mixture comprising a glucosaminyl 3-O sulfotransferase enzyme ( ...

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Номер записи: 17
20-01-2022 дата публикации

POLYMER GELS AND METHODS FOR MONITORING GEL INTEGRITY IN WELLBORES

Номер: US20220017702A1
Автор: Abdel-Fattah Amr I., Servin Jesus Manuel Felix
Принадлежит: Saudi Arabian Oil Company

A polymer gel may comprise a polymer gel base material and superparamagnetic nanoparticles. At least 25 wt. % of the superparamagnetic nanoparticles may have diameters in a first size range between a first diameter and a second diameter. At least 25 wt. % of the superparamagnetic nanoparticles may have diameters in a second size range between a third diameter and a fourth diameter. The Brownian relaxation time of the portion of the superparamagnetic nanoparticles in the first size range may be at least 5 times the Neel relaxation time of the portion of the superparamagnetic nanoparticles in the first size range. The Neel relaxation time of the portion of the superparamagnetic nanoparticles in the second size range may be at least 5 times the Brownian relaxation time of the portion of the superparamagnetic nanoparticles in the second size range. Methods for monitoring gel integrity in a wellbore are further included. 1. A polymer gel in a gelled or non-gelled state , the polymer gel comprising:a polymer gel base material comprising at least water and polymer; and at least 25 wt. % of the superparamagnetic nanoparticles have diameters in a first size range between a first diameter and a second diameter, where the first diameter is less than the second diameter, where the difference between the first diameter and the second diameter is 4 nm, and where the diameter of the particles in the first size range is measured as the core diameter;', 'at least 25 wt. % of the superparamagnetic nanoparticles have diameters in a second size range between a third diameter and a fourth diameter, where the third diameter is less than the fourth diameter, where the difference between the third diameter and the fourth diameter is 8 nm, and where the diameter of the particles in the second size range is measured as the hydrodynamic diameter;', 'the second diameter is less than or equal to the third diameter;', 'the Brownian relaxation time of the portion of the superparamagnetic ...

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Номер записи: 18
14-01-2016 дата публикации

DEPOLYMERISATION OF ALGINIC ACID

Номер: US20160009829A1
Автор: JUUL Anne Grete, Klinger Markus, STENBÆK Dorthe, TOQEER Ahmed
Принадлежит:

Depolymerisation of alginic acid by microwave treatment. 1. A method of depolymerisation of alginic acid , said method comprising the steps of:a) providing alginic acid as a starting material for step b, wherein the alginic acid starting material has a pH in the range of 0-4.4 and wherein the dry matter content of the alginic acid starting material is in the range of 5-100% w/w, andb) treating said alginic acid starting material with microwave irradiation to obtain a depolymerised alginic acid material.2. The method according to claim 1 , wherein the microwave frequency is between 300 MHz and 300 GHz claim 1 , such as 300 MHz to 30 GHz claim 1 , preferably 300 MHz to 3 GHz.3. The method according to claim 1 , wherein the concentration of alginic acid in the alginic acid starting material is in the range of 7.5-100% w/w based on dry matter claim 1 , such as in the range of 80-100% w/w based on dry matter claim 1 , preferably in the range of 90-100% w/w based on dry matter.4. The method according to claim 1 , wherein the alginic acid starting material has a pH in the range of 0-3.5.5. The method according to claim 1 , wherein the dry matter content of the alginic acid starting material is in the range of 5-90% w/w.6. The method according to claim 1 , wherein the starting alginic acid material has a weight average molecular weight of 1 claim 1 ,500 claim 1 ,000-50 claim 1 ,000 Da.7. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in a mixture with one or more selected solvents from the group consisting of water claim 1 , methanol claim 1 , ethanol claim 1 , and isopropanol.8. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in water.9. The method according to claim 1 , wherein the alginic acid starting material further comprises a reducing and/or oxidizing agent.10. The method according to claim 1 , wherein the alginic acid starting material is drained and/or pressed ...

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Номер записи: 19
27-01-2022 дата публикации

ENCAPSULATION BY CROSS-LINKING OF ANIONIC POLYMERS BY PH INDUCED DISSOCIATION OF CATION-CHELATE COMPLEXES

Номер: US20220025132A1
Автор: Scher Herbert B., Strobel Scott, Wong Dana, Zicari Tina Jeoh
Принадлежит: The Regents of the University of California

Microencapsulation methods are provided using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. During the formation of this composition, the generally acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Multivalent cations are sequestered in cation-chelate complexes. Cross-linkable polymers in this solution will remain freely dissolved until some disruption of equilibrium induces the release of the free multivalent cations from the cation-chelate complex. Vaporization of the volatile base drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix. During spray-drying, the formation of a wet particle, polymer cross-linking, and particle drying occur nearly simultaneously. 1. A method of cross-linking polymer molecules , the method comprising:(a) providing a solution of an acidic chelating agent with a volatile base;(b) adding at least one source of multivalent cations to form cation-chelate complexes in the solution;(c) mixing molecules of at least one anionic polymer with the solution of cation-chelate complexes and volatile base; and(d) vaporizing the volatile base of the solution, thereby disassociating the cation-chelate complexes and releasing multivalent cations and cross-linking the polymer molecules with said multivalent cations.2. The method of claim 1 , said acidic chelating agent solution further comprising a weak acid buffer.3. The method of claim 2 , wherein said weak acid is an acid selected from the group consisting of benzoic acid claim 2 , lactic acid claim 2 , ascorbic acid claim 2 , adipic acid claim 2 , acrylic acid claim 2 , glutaric acid claim 2 , ascorbic acid claim 2 , gallic acid claim 2 , caffeic acid claim 2 , L-Tartaric acid claim 2 , D-Tartaric acid claim 2 , ...

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Номер записи: 20
03-02-2022 дата публикации

Cross-Linkable Polymer, Hydrogel, and Method of Preparation Thereof

Номер: US20220031909A1
Автор: Céline Samira Wyss, Christophe Moser, Dominique Pioletti, Peyman Karami, Pierre-Etienne Bourban
Принадлежит: Ecole Polytechnique Federale de Lausanne EPFL

The invention relates to a cross-linkable polymer including a base polymer including functional groups at least some of which have been reacted with a first organic molecule including a cross-linkable unit and with a second organic molecule capable of bonding to organic and/or inorganic substrates. The invention further relates to a hydrogel including the cross-linkable polymer that includes cross-linkable polymer strands, wherein at least some of the cross-linkable units of different cross-linkable polymer strands have reacted to form a covalent bond thereby forming a covalently linked network. The invention further relates to a method for the preparation of the hydrogel and to the use of the hydrogel.

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Номер записи: 21
03-02-2022 дата публикации

Large Pore Agarose

Номер: US20220032266A1
Автор: Akerblom Anna, Hansson Jesper, Jansson David, Michaelsson Emma
Принадлежит:

The present invention relates to porous cross-linked agarose gel beads which have a low agarose content, a method for the preparation of the beads and their use in chromatographic applications. The beads are suitable for the separation/purification of biomolecules from a biological sample. Due to the high porosity of the beads, they are especially suitable for separation/isolation of larger particles, such as virus particles e.g. adeno virus. 1. A method of preparing porous cross-linked agarose gel beads comprising the steps of: (i) preparing an agarose aqueous phase having an agarose concentration of 0.3-0.8% w/v,', '(ib) adding magnetite,', '(ii) preparing a water-immiscible oil phase in which at least one emulsifier is dissolved,', '(iii) mixing the water phase and the oil phase to obtain a W/O emulsion, and', '(iv) allowing the W/O emulsion to form beads,, 'a) emulsifying agarose, comprising the steps ofb) cross-linking the emulsified agarose one or several times by reacting the beads with a cross-linking agent, andc) coupling of ligands.2. The method of wherein in step a)(i) the agarose aqueous phase is prepared in a concentration of 0.4-0.6% w/v at a temperature of about 40-95° C.,(iii) the water phase and the oil phase are mixed at a temperature of about 40-70° C., and(iv) the W/O emulsion is allowed to attain a temperature of 10-30° C., such as about 22° C. and form particles.3. The method of further comprising a step of grafting the beads from step b) with extenders.4. The method of claim 1 , wherein the cross-linking agent is epichlorohydrin.5. Porous cross-linked agarose gel beads obtained by the method of .6. Porous spherical cross-linked agarose gel beads claim 1 , comprising an agarose concentration of about 0.3-0.8% w/v claim 1 , or a dry weight of about 5-15 mg/mL claim 1 , and a magnetic material.7. The porous cross-linked agarose gel beads according to claim 6 , having a size of 40-200 μm.8. The porous cross-linked agarose gel beads according to ...

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Номер записи: 22
03-02-2022 дата публикации

GEL PRECURSOR, NUCLEIC ACID AMPLIFICATION REAGENT GEL, STORAGE CHIP AND USING METHOD THEREOF

Номер: US20220033591A1
Автор: Xu Weifeng
Принадлежит:

The present disclosure can provide a gel precursor, a nucleic acid amplification reagent gel, a storage chip and a using method thereof. The gel precursor includes: a sodium alginate main solution mixed with at least one of the following components: starch, dextrin, chitosan, agarose and gelatin, where the sodium alginate main solution has a mass concentration range from 0.01% w/v to 5% w/v. 1. A gel precursor , comprising: a sodium alginate main solution mixed with at least one of following components:starch;dextrin;chitosan;agarose; andgelatin;wherein the sodium alginate main solution has a mass concentration range from 0.01% w/v to 5% w/v.2. A nucleic acid amplification reagent gel claim 1 , comprising the gel precursor of claim 1 , and further comprising:one or more reagents, mixed in the gel precursor, needed for nucleic acid amplification, and 'wherein the first ion and the gel precursor are subjected to a cross-linking reaction to form a gel, and to embed the one or more reagents into the gel; and', 'a salt solution containing a first ion,'}the nucleic acid amplification reagent gel is configured that when a salt solution containing a second ion is added, the second ion and the gel are subjected to an ion exchange reaction to dissolve the gel, and to release the one or more reagents.3. The nucleic acid amplification reagent gel of claim 2 , wherein the first ion is a divalent metal cation.4. The nucleic acid amplification reagent gel of claim 3 , wherein the divalent metal cation is at least one of: a Caion and a Baion.5. The nucleic acid amplification reagent gel of claim 2 , wherein the second ion is a monovalent metal cation.6. The nucleic acid amplification reagent gel of claim 5 , wherein the monovalent metal cation is at least one of: a Naion and a K ion.7. The nucleic acid amplification reagent gel of claim 6 , wherein:the salt solution containing the second ion is a sodium citrate solution containing the second ion, orthe salt solution containing the ...

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Номер записи: 23
21-01-2016 дата публикации

ORGANIC ACID CARBOHYDRATE BINDERS AND MATERIALS MADE THEREWITH

Номер: US20160017063A1
Автор: MUELLER Gert R.
Принадлежит:

A binder comprising a polymeric binder comprising the products of a carbohydrate reactant and organic acid is disclosed. The binder is useful for consolidating loosely assembled matter, such as fibers. Fibrous products comprising fibers in contact with a carbohydrate reactant and an organic acid are also disclosed. The binder composition may be cured to yield a fibrous product comprising fibers bound by a cross-linked polymer. Further disclosed are methods for binding fibers with the carbohydrate based binder using an organic acid.

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Номер записи: 24
21-01-2021 дата публикации

METHOD FOR PREPARING HYALURONIC ACID HYDROGEL MICROPARTICLES AND USE THEREOF IN REPAIRING ARTICULAR CARTILAGE DEFECTS

Номер: US20210015967A1
Автор: Chang Je-Ken, Chen Chung-Hwan, Chen Hui-Ting, Ho Mei-Ling, TEONG Benjamin, WU Shun Cheng
Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

A method for preparing hyaluronic acid hydrogel microparticles and a use thereof in repairing articular cartilage defects, the method for preparing hyaluronic acid hydrogel microparticles includes: (a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate; (b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction so as to obtain a hyaluronic acid hydrogel; and (c) passing the hyaluronic acid hydrogel through a sieve to obtain hyaluronic acid hydrogel microparticles. 1. A method for preparing hyaluronic acid hydrogel microparticles , comprising:(a) reacting hyaluronic acid with methacrylic anhydride to synthesize a methacrylated hyaluronic acid conjugate;(b) mixing the methacrylated hyaluronic acid conjugate with a photoinitiator, and irradiating ultraviolet light to carry out a photopolymerization reaction to obtain a hyaluronic acid hydrogel; and(c) passing the hyaluronic acid hydrogel through a sieve to obtain the hyaluronic acid hydrogel microparticles.2. The method of claim 1 , wherein the photoinitiator is 2-methyl-1-[4-(hydroxyethoxy)phenyl]-2-methyl-1-propanone.3. The method of claim 1 , wherein the mesh size of the sieve is from 10 to 500 μm.4. The method of claim 1 , wherein the particle size of the hyaluronic acid hydrogel microparticles is from 1 to 300 μm.5. The method of claim 1 , wherein the particle size of the hyaluronic acid hydrogel microparticles is from 70 to 200 μm.6. The method of claim 1 , wherein the particle size of the hyaluronic acid hydrogel microparticles is from 100 to 150 μm.7. The method of claim 1 , wherein the degree of esterification of the hyaluronic acid hydrogel microparticles is from 15% to 140%.8. A method for treating articular cartilage defects comprising intraarticularly administering a composition to articular cartilage defects of a subject claim 1 , wherein the composition ...

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Номер записи: 25
16-01-2020 дата публикации

Method for Preparing Porous Scaffold for Tissue Engineering, Cell Culture and Cell Delivery

Номер: US20200016294A1
Автор: Catherine Le Visage, Didier Letourneur
Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM, Université de Paris

The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).

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Номер записи: 26
17-01-2019 дата публикации

METHOD FOR DEACETYLATION OF BIOPOLYMERS

Номер: US20190016830A1
Автор: HARRIS Craig Steven, Olsson Johan
Принадлежит: GALDERMA S.A.

A method for at least partial deacetylation of a biopolymer comprising acetyl groups, including: a1) providing a biopolymer including acetyl groups; a2) reacting the biopolymer including acetyl groups with hydroxylamine (NHOH) or a salt thereof at a temperature of 100° C. or less for 2-200 hours to form an at least partially deacetylated biopolymer; and a3) recovering the at least partially deacetylated biopolymer. 1. A method for at least partial deacetylation of a glycosaminoglycan comprising acetyl groups , comprising:a1) providing a glycosaminoglycan comprising acetyl groups;{'sub': '2', 'a2) reacting the glycosaminoglycan comprising acetyl groups with hydroxylamine (NHOH) or a salt thereof at a temperature of 100° C. or less for 2-200 hours to form an at least partially deacetylated glycosaminoglycan; and'}a3) recovering the at least partially deacetylated glycosaminoglycan.2. The method according to claim 1 , wherein the glycosaminoglycan selected from the group consisting of hyaluronic acid claim 1 , chondroitin and chondroitin sulfate claim 1 , and mixtures thereof.3. The method according to claim 1 , wherein the weight average molecular weight of the recovered at least partially deacetylated glycosaminoglycan is at least 10% of the weight average molecular weight of the glycosaminoglycan comprising acetyl groups in step a1).4. The method according to claim 1 , wherein the glycosaminoglycan comprising acetyl groups in step a1) has a degree of acetylation in the range of 98-100%.5. The method according to claim 1 , wherein the recovered at least partially deacetylated glycosaminoglycan has a degree of acetylation at least 1% less than that of the glycosaminoglycan comprising acetyl groups in step a1).6. The method according to claim 1 , wherein step a2) comprises reacting the glycosaminoglycan comprising acetyl groups with the hydroxylamine or salt thereof at a temperature of 100° C. or less.7. (canceled)8. The method according to claim 1 , wherein step a2) ...

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Номер записи: 27
21-01-2021 дата публикации

ALGINATE MICROCAPSULES FOR CELL ENCAPSULATION AND, MANUFACTURING METHOD THEREFOR

Номер: US20210017348A1
Автор: CHOI Ki Myung, Lee Dong Yun, LEE Jae Bin, PARK Jae Kyung, SHIM Joo Hyun
Принадлежит:

The present disclosure provides a surface-modified alginate micro-capsule having a core-shell structure in which a core is fluidizable phase alginate, and a shell is alginate hydrogel crosslinked with epigallocatechin gallate dimer, a preparation method thereof, and a cell encapsulation method using the same. 1. A surface-modified alginate micro-capsule comprising a core-shell structure in which a core is fluidizable phase alginate , and a shell is alginate hydrogel crosslinked with epigallocatechin gallate dimers.2. The surface-modified alginate micro-capsule of claim 1 , wherein some of the epigallocatechin gallate dimers of the shell are coupled to other epigallocatechin gallate dimers via oxidation.3. The surface-modified alginate micro-capsule of claim 1 , wherein the shell further comprises an alginate coating layer.4. The surface-modified alginate micro-capsule of claim 3 , wherein the alginate coating layer comprises an amide bond with the epigallocatechin gallate dimer of the shell.5. The surface-modified alginate micro-capsule of claim 1 , wherein the shell comprises a plurality of hollows connected to each other in a three-dimensional manner.6. The surface-modified alginate micro-capsule of claim 1 , wherein the core is a liquid phase alginate or a mixture of liquid phase alginate and alginate hydrogel.7. The surface-modified alginate micro-capsule of claim 1 , wherein the micro-capsule provides for cell encapsulation.8. A method for preparing a surface-modified alginate micro-capsule claim 1 , the method comprising:(1) a core preparation step of preparing a calcium-alginate micro-capsule;(2) a shell preparation step in which an alginate-epigallocatechin gallate dimer crosslinked product is formed on a surface of the calcium-alginate micro-capsule by reacting the calcium-alginate micro-capsule and epigallocatechin gallate dimers with each other; and(3) a core liquefaction step of chelating calcium ions of calcium-alginate to the epigallocatechin gallate ...

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Номер записи: 28
28-01-2016 дата публикации

Protective garment for an individual that maintains his "cool" look while inconspicuously protecting him

Номер: US20160021947A1
Автор: DOR-EL David, Shalev Itzhak
Принадлежит:

The present invention is a protective garment for individuals which includes a hoodie with a hood and a pair of sleeves, a head protective element and elbow, shoulder, wrist, back and torso protective pads. The head protective element is coupled to the hood of the hoodie by a fastening system. Each of the elbow protective pads is coupled to the hoodie by a fastening system. Protective elements are spacer fabrics filled with a shear thickening (also known as dilatant) gel having flexibility and drape-ability so as not to degrade the natural “cool” look of a standard garment. 1. A protective garment for individuals comprises:a. a hoodie with a hood and a pair of long sleeves and unobtrusive protective elements composed of 3 to 20 millimeters thick gel filled spacer fabric,a hoodie with a hood and a pair of sleeves;b. a protective element being coupled to said hood of said hoodie by a fastening system; andc. Elbow, shoulder, wrist, back and torso protective pads elements each of which being coupled to one of parts of said sleeves of said hoodie garment by a fastening system whereby said protective garment not only maintains a look that most individuals think is “cool,” but also provides protection of other more conspicuous protective garments inconspicuously.2. A protective garment according to wherein said protective elements are spacer fabrics filled with a shear thickening (also known as dilatant) gel and sealed around the perimeter wherein said spacer fabrics contain gels yielding enhanced impact protection (reduction of >80% in transmitted force at 10 Joules when tested according to EN1621-1) stemming from the combination of the resiliency inherent in the spacer fabric construction principle and the reaction of the contained gel to impact and shear.3. The protective elements of having flexibility and drape-ability so as not to degrade the natural “cool” look of a standard garment.4. The dilatant gel of composed of one or more of the following combinations: silica ...

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Номер записи: 29
16-01-2020 дата публикации

HIGH-PERFORMANCE ELECTRODES WITH A POLYMER NETWORK HAVING ELECTROACTIVE MATERIALS CHEMICALLY ATTACHED THERETO

Номер: US20200020948A1
Автор: ELLISON Nicole, HUANG Xiaosong
Принадлежит: GM GLOBAL TECHNOLOGY OPERATIONS LLC

High performance electrodes for electrochemical devices having a polymer network with an electroactive material chemically attached to a crosslinked polymer matrix are disclosed. A method includes mixing an electrode slurry and forming a polymer network within the electrode slurry. The electrode slurry includes an electroactive material, an electrically conductive filler, a plurality of polymer chains, and a plurality of chemical crosslinking precursors. Each chemically crosslinking precursor is configured to (i) chemically crosslink the plurality of polymer chains and (ii) chemically attach the electroactive material to the plurality of polymer chains. 1. A method comprising:mixing an electrode slurry including an electroactive material, an electrically conductive filler, a plurality of polyacrylic acid polymer chains, and a plurality of isocyanate chemical crosslinking precursors, each of the chemical crosslinking precursors chemically crosslinking the plurality of polymer chains and chemically attaching the electroactive material to the plurality of polymer chains; andforming a polymer network within the electrode slurry.2. The method of claim 1 , further comprising:applying the electrode slurry having the polymer network suspended therein to a current collector; anddrying the electrode slurry to thereby form an electrode.3. The method of claim 1 , further comprising grafting the plurality of chemical crosslinking precursors to the plurality of polymer chains claim 1 , the grafting including:mixing the plurality of chemical crosslinking precursors with the plurality of polymer chains to thereby form a grafting solution; andresting the grafting solution for at least about ten minutes prior to forming the polymer network such that substantially all of the plurality of chemical crosslinking precursors is grafted to the plurality of polymer chains.4. The method of claim 1 , wherein the plurality of chemical crosslinking precursors is selected from a group consisting ...

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Номер записи: 30
10-02-2022 дата публикации

CROSSLINKED HYALURONIC ACID, HYALURONIC ACID HYDROGEL, AND METHOD FOR PRODUCING CROSSLINKED HYALURONIC ACID AND HYALURONIC ACID HYDROGEL

Номер: US20220040374A1
Автор: KIM Jun Young, KIM Se Kweon, KIM Soo Jin, Kim Yong Woo, LEE Back Ho, Park Hyo Seung, SHIN Chung Leol
Принадлежит: HANMI PHARM. CO., LTD

Provided are a crosslinked hyaluronic acid product in the form of powder and a method of preparing the same, and a crosslinked hyaluronic acid hydrogel prepared using the crosslinked hyaluronic acid product in the form of powder, and a method of preparing the same. The crosslinked hyaluronic acid hydrogel according to the present disclosure exhibits excellent rheological properties, and mass production thereof is easy and quality uniformity thereof is excellent. 1. A method of preparing a crosslinked hyaluronic acid product in the form of powder , the method comprising:preparing an aqueous solution comprising hyaluronic acid, a salt thereof, or a mixture thereof;adding a crosslinking agent to the aqueous solution to cause a crosslinking reaction of the hyaluronic acid to occur; andadding ethanol to the aqueous solution to solidify the hyaluronic acid into particles.2. The method of claim 1 , wherein claim 1 , when ethanol is added to the aqueous solution claim 1 , the ethanol is added at a rate of 20 mL/min to 1000 mL/min.3. The method of claim 1 , wherein claim 1 , when ethanol is added claim 1 , a rate of volume change of ethanol with respect to the total volume of the mixed solution is 0.5% (v/v)/min to 35% (v/v)/min.4. The method of claim 1 , wherein the crosslinking agent is comprised in an amount of 10 μL to 500 μL with respect to 1 g of hyaluronic acid claim 1 , a salt thereof claim 1 , or a mixture thereof.5. The method of claim 1 , wherein a volume ratio of the aqueous solution and ethanol added to the aqueous solution is 1:1 to 10.6. The method of claim 1 , further comprising a crosslinking reaction of the aqueous solution comprising hyaluronic acid particles.7. The method of claim 1 ,further comprising washing the prepared crosslinked hyaluronic acid product with ethanol or a solution comprising ethanol.8. A crosslinked hyaluronic acid product in the form of powder claim 1 , prepared according to the method of .9. The crosslinked hyaluronic acid product ...

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Номер записи: 31
24-01-2019 дата публикации

INJECTABLE MONOPHASE HYDROGELS

Номер: US20190022130A1
Автор: Lebreton Pierre F.
Принадлежит:

An injectable monophase hydrogel is provided that is made of a reaction mixture of hyaluronic acids having different molecular weights. 1. An injectable composition comprising a hyaluronic acid gel , the hyaluronic acid gel comprising:about 5% by weight to about 50% by weight of a first hyaluronic acid having an average molecular weight in the range of about 1.1×106 Da to about 5×106 Da; andabout 50% by weight to about 95% by weight of a second hyaluronic acid having an average molecular weight in the range of about 1×104 Da to about 9.9×105 Da;wherein the hyaluronic acid gel is crosslinked via covalent bonding between a bifunctional crosslinker and hydroxyl moieties of the first and second hyaluronic acids.2. The injectable composition of claim 1 , wherein the hyaluronic acid gel comprises about 5% by weight to about 30% by weight of the first hyaluronic acid.3. The injectable composition of claim 1 , wherein the hyaluronic acid gel comprises about 70% by weight to about 95% by weight of the second hyaluronic acid.4. The injectable composition of claim 1 , wherein the bifunctional crosslinker is selected from the group consisting of bifunctional crosslinking agents epichlorohydrin claim 1 , divinyl sulfone claim 1 , 1 claim 1 ,4-bis(2 claim 1 ,3-epoxypropoxy)butane claim 1 , 1 claim 1 ,4-bisglycidoxybutane claim 1 , 1 claim 1 ,4-butanediol diglycidyl ether (BDDE)) claim 1 , 1 claim 1 ,2-bis(2 claim 1 ,3-epoxypropoxy)ethylene claim 1 , 1-(2 claim 1 ,3-epoxypropyl)-2 claim 1 ,3-epoxycyclohexane claim 1 , formaldehyde claim 1 , glutaraldehyde claim 1 , and crotonaldehyde.5. The injectable composition of claim 4 , wherein the bifunctional crosslinker is (BDDE).6. The injectable composition of having a concentration of hyaluronic acid gel of between 10 and 40 mg/g.7. The injectable composition of having a concentration of hyaluronic acid gel of between 20 and 30 mg/g.8. The injectable composition of having a concentration of hyaluronic acid gel of 26 mg/g.9. The ...

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Номер записи: 32
10-02-2022 дата публикации

Process for continuous supercritical drying of aerogel particles

Номер: US20220041817A1
Автор: Dirk Weinrich, Fynn Missfeldt, lrina Smirnova, Marc Fricke, Pavel GURIKOV, Raman SUBRAHMANYAM, Sohajl MOVAHHED, Wibke LOELSBERG
Принадлежит: BASF SE

Processes for drying gel particles, in particular for producing aerogels, involve providing a suspension containing gel particles and a solvent, introducing the suspension into a column where carbon dioxide flows in countercurrent, and removing dried aerogel particles from the column. The suspension is introduced in the top region of the column and dried aerogel particles are removed in the lower region. Pressure and temperature in the column are set such that the mixture of carbon dioxide and solvent is virtually supercritical or is supercritical. The aerogel particles can be discharged via discharge vessels or continuous decompression. Aerogel particles can be obtained by such a process and the aerogel particles can be used for medical and pharmaceutical applications, as additive or carrier material for additives for foods, as catalyst support, for cosmetic, hygiene, washing and cleaning applications, for production of sensors, for thermal insulation, or as a core material for VIPs.

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Номер записи: 33
28-01-2021 дата публикации

Hyaluronic acid composition for external use on skin and a method for skin moisturizing comprising applying the same onto the skin

Номер: US20210022981A1
Автор: HaeWon Jeong, Jiwook JANG, Kyungho Choi, Sungyeon CHO
Принадлежит: Amorepacific Corp

The present disclosure provides a hyaluronic acid composition for external use on skin. The hyaluronic acid composition for external use on skin includes crosslinked hyaluronic acid at a high concentration, and a water swelling degree of the crosslinked hyaluronic acid is specified to provide an excellent skin moisturizing effect and feeling of use.

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Номер записи: 34
24-01-2019 дата публикации

HYDROLYSIS OF ESTER BONDS IN AMIDE CROSSLINKED GLYCOSAMINOGLYCANS

Номер: US20190023855A1
Автор: MOJARRADI Hotan, Olsson Johan
Принадлежит: GALDERMA S.A.

A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include ester crosslinks formed as byproducts during the amide crosslinking; and ii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking. 1. A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules , said method comprising:i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise ester crosslinks formed as byproducts during the amide crosslinking; andii) subjecting the crosslinked glycosaminoglycans to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking.2. A method according to claim 1 , wherein i) comprises the steps:a) providing a solution comprising glycosaminoglycans;b) activating carboxyl groups on the glycosaminoglycans with a coupling agent, to form activated glycosaminoglycans;c) crosslinking the activated glycosaminoglycans via their activated carboxyl groups using a di- or multiamine functional crosslinker to provide glycosaminoglycans crosslinked by amide bonds.3. A method according to claim 1 , wherein the glycosaminoglycan is selected from the group consisting of hyaluronic acid claim 1 , chondroitin and chondroitin sulfate claim 1 , and mixtures thereof.4. A method according to claim 1 , wherein i) comprises the steps:a) providing a solution comprising an at least partially deacetylated glycosaminoglycan and optionally a second glycosaminoglycan;b) activating carboxyl groups on the at least partially deacetylated glycosaminoglycan and/or the optional second glycosaminoglycan with a coupling agent, to form activated glycosaminoglycans;c) crosslinking the activated glycosaminoglycans via their activated ...

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Номер записи: 35
24-01-2019 дата публикации

REDUCED SALT PRECIPITATION IN CARBOHYDRATE CONTAINING BINDER COMPOSITIONS

Номер: US20190023932A1
Автор: Alavi Kiarash, Asrar Jawed, Lester Uranchimeg, Miele Philip Francis
Принадлежит:

Aqueous binder compositions with reduced rates of salt precipitation are described. The compositions may include a carbohydrate and a sequestrant for sequestering one or more multivalent ions (e.g., Ca, Mg, Ba, Al, Fe, Fe, etc.). The sequestrant reduces a precipitation rate for the multivalent ions from the aqueous binder composition. Methods of reducing salt precipitation from a binder composition are also described. The methods may include the steps of providing an aqueous binder solution having one or more carbohydrates. They may also include adding a sequestrant for one or more multivalent ions to the aqueous binder solution. The sequestrant reduces a precipitation rate for the multivalent ions from the binder composition. 1. An aqueous binder composition comprising:a carbohydrate;a sequestrant for one or more multivalent ions, wherein the sequestrant reduces a precipitation rate for the multivalent ions from the aqueous binder composition; anda polymerization catalyst comprising an inorganic ammonium salt, wherein the inorganic ammonium salt also reacts with the carbohydrate.2. The aqueous binder composition of claim 1 , wherein the carbohydrate includes at least one reducing sugar.3. The aqueous binder composition of claim 2 , wherein the reducing sugar comprises dextrose.4. The aqueous binder composition of claim 1 , wherein the sequestrant comprises an organic acid or a salt of an organic acid.5. The aqueous binder composition of claim 4 , wherein the organic acid comprises citric acid.6. The aqueous binder composition of claim 1 , wherein the inorganic ammonium salt comprises one or more ammonium salts of sulfuric acid claim 1 , phosphoric acid claim 1 , nitric acid claim 1 , or sulfonic acid.7. The aqueous binder composition of claim 1 , wherein the inorganic ammonium salt comprises an ammonium sulfate salt or an ammonium phosphate salt.8. An aqueous binder composition comprising:a carbohydrate;a sequestrant for one or more multivalent ions, wherein the ...

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Номер записи: 36
23-01-2020 дата публикации

RECOVERY OF MINING PROCESSING PRODUCT USING BORONIC ACID-CONTAINING POLYMERS

Номер: US20200024148A1
Автор: "OBrien Kevin", Cheng Weiguo, Huang Xinyu C., McDonald Kevin, Wang Jinfeng, Wang Jing, Wei Mingli
Принадлежит:

Methods and compositions for improving performance of flocculants in an industrial production process. Methods include pH triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The pH trigger can be provided by a fluid having a pH of 8 or more. The production process can be a Bayer Process and the fluid is caustic liquor or slurry in the fluid circuit of the Bayer, wherein the reaction time is reduced over conventional methods and the cross-linked dextran composition effectuates improved flocculation of the trihydrate particles. 1. A method for solid-liquid separation in a mining process , the method comprising:combining a first composition with a fluid stream of a mining process, the first composition comprising a boronic acid-containing polymer, the fluid stream having a pH of 8 or more;combining a second composition with the fluid stream, the second composition comprising an polysaccharide; andseparating a solid from the fluid stream.2. The method of comprising combining the first composition before combining the second composition.3. The method of comprising combining the second composition before combining the first composition.4. The method of wherein the first composition and the second composition are combined at the same time.5. The method of wherein the boronic acid-containing polymer comprises at least one polymerized water soluble vinyl monomer and at least one polymerized vinyl monomer containing a boronic acid moiety.6. The method of wherein at least one water soluble vinyl monomer is acrylamide and the boronic acid-containing polymer is a water soluble boronic acid-containing polyacrylamide.7. The method of wherein the boronic acid-containing polymer has a reduced specific viscosity of at least about 0.2 dl/g.8. The method of wherein the first composition is combined in the form of latex claim 1 , an aqueous solution or a dry powder.9. The method of claim 1 , ...

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Номер записи: 37
01-02-2018 дата публикации

TARGETED NANOPARTICLES

Номер: US20180028684A1
Автор: Winchurch Richard A., Yeoman Roy R.
Принадлежит: nanoDERM Sciences, Inc.

The invention in the various aspects provides nanogel compositions that are safe for topical, local, and/or systemic delivery, and which can be targeted to select tissues or cells, including pathogens. In some embodiments, conjugation of antibiotics to the nanogel surface, and in particular antibiotics that disrupt outer membranes of Gram negative bacteria or antibiotics that inhibit cell wall synthesis, provide for highly effective targeting and killing of bacterial pathogens, including drug-resistant bacteria. 1. A hydrogel composition , comprising:a population of polymeric nanoparticles having conjugated to their surface polymyxin B and/or Vancomycin.2. The hydrogel composition of claim 1 , wherein the nanoparticles have polymyxin B conjugated to their surface.3. The hydrogel composition of claim 1 , wherein the nanoparticles have vancomycin conjugated to their surface.4. The hydrogel composition of claim 1 , wherein the nanoparticles have polymyxin B and vancomycin conjugated to their surface.5. The hydrogel composition of claim 1 , wherein the nanoparticles comprise cross-linked copolymers.6. The hydrogel composition of claim 5 , wherein at least one co-polymer is a polysaccharide claim 5 , which is either linear claim 5 , cyclic or branched.7. The hydrogel composition of claim 6 , wherein the polysaccharide is a glucan.8. The hydrogel composition of claim 6 , wherein the polysaccharide is at least one of dextran claim 6 , chitosan claim 6 , and cyclodextran.9. The hydrogel composition of claim 5 , wherein at least one co-polymer is selected from polyvinyl alcohol claim 5 , acrylate claim 5 , and polyacrylate.1040.-. (canceled)41. A hydrogel preparation comprising nanoparticles of dextran cross-linked with poloxamer claim 5 , and having surface conjugated antibiotic that disrupts outer membrane of gram negative bacteria claim 5 , or inhibits cell wall synthesis of gram positive or gram negative bacteria.42. The hydrogel composition of claim 41 , wherein the ...

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Номер записи: 38
24-04-2014 дата публикации

Polysaccharide-based hydrogel polymer and uses thereof

Номер: US20140113821A1
Автор: Benjamin Charles Lehtovaara, Drew William Davidson, Frank GU, Mohit Singh Verma
Принадлежит: Individual

A method of preparing a hydrogel for delivery of an active agent. The method includes providing an aqueous solution that includes the active agent; dispersing or dissolving a gel-forming polymer in the aqueous solution to form a polymer solution; and cross-linking the polymer in the polymer solution to form the hydrogel which encapsulates the active agent.

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Номер записи: 39
30-01-2020 дата публикации

METHOD FOR PREPARING ACYLATED CROSSLINKED GLYCOSAMINOGLYCANS

Номер: US20200030219A1
Автор: HARRIS Craig Steven, Olsson Johan
Принадлежит: GALDERMA S.A.

A method of preparing a hydrogel product including crosslinked glycosaminoglycan molecules, said method including: i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans include residual amine groups; and ii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans. 1. A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules , said method comprising:i) providing a glycosaminoglycan crosslinked by amide bonds, wherein the crosslinked glycosaminoglycans comprise residual amine groups; andii) acylating residual amine groups of the crosslinked glycosaminoglycans provided in i) to form acylated crosslinked glycosaminoglycans.2. A method according to claim 1 , wherein i) comprises the steps:a) providing a solution comprising an at least partially deacetylated glycosaminoglycan and optionally a second glycosaminoglycan;b) activating carboxyl groups on the at least partially deacetylated glycosaminoglycan and/or the optional second glycosaminoglycan with a coupling agent, to form activated glycosaminoglycans;c) crosslinking the activated glycosaminoglycans via their activated carboxyl groups using amino groups of the at least partially deacetylated glycosaminoglycans to provide glycosaminoglycans crosslinked by amide bonds.3. A method according to claim 2 , whereinthe at least partially deacetylated glycosaminoglycan is selected from the group consisting of deacetylated hyaluronic acid, deacetylated chondroitin and deacetylated chondroitin sulfate, and mixtures thereof.4. A method according to claim 2 , wherein the at least partially deacetylated glycosaminoglycan is deacetylated hyaluronic acid.5. A method according to claim 2 , wherein the at least partially deacetylated glycosaminoglycan has a degree of acetylation of 99% or less claim 2 , and a weight average molecular weight of 0.1 MDa or more.6. A method ...

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Номер записи: 40
30-01-2020 дата публикации

FILTER FOR THE EXCHANGE OF HEAT AND MOISTURE FOR APPLICATION IN THE MEDICAL FIELD AND PROCEDURE FOR THE PRODUCTION THEREOF

Номер: US20200030566A1
Автор: SANDRI Monica, SPRIO Simone, TAMPIERI Anna
Принадлежит:

Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment. 1. Process for preparing a material useful for the production of HME filters , which comprises the following steps:a) preparing an acidic aqueous solution of chitosan in a concentration from 1 to 2.5% by weight;b) preparing an aqueous solution of a gelatin of animal origin in a concentration from 2.5 to 5% by weight, operating at a temperature between 40 and 50° C.;c) mixing the two solutions thus obtained in such quantities as to obtain a weight ratio gelatin:chitosan from 80:20 to 50:50, preferably 70:30, gently stirring the resulting solution to avoid the formation of a foam until obtaining a homogeneous solution, and subsequently diluting the mixture to obtain a total polymer concentration of from 2 to 4%, preferably 2%, by weight;c′) optionally, adding a chemical crosslinker to the solution obtained in step c);d) pouring the solution prepared in step c) or in step c′) into a container with the bottom made of a material having thermal conductivity greater than or equal to 15 W/(m·K) and side walls made of a material having thermal conductivity less than or equal to 1 W/(m·K);d′) in case step c′) has been carried out, keeping said contain closed until obtaining a ...

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Номер записи: 41
24-02-2022 дата публикации

HEMOSTATIC AGENT AND METHOD OF PRODUCTION THEREOF

Номер: US20220054529A1
Автор: MONY Ullas, RANGASAMY Jayakumar, SUNDARAM Nivedhitha MuthiahPillai, VARMA Praveen Kerala
Принадлежит:

A composition and method of preparing the composition for rapid and effective hemostasis is provided. The composition includes a first agent to induce platelet plug formation, a second to induce vasoconstriction and a third agent for activation of coagulation cascade. The composition comprises of 0.01% to 5% of chitosan; 0.01% to 0.25% of potassium aluminum sulphate; and 0.01% to 0.25% calcium salt. The clotting time of the composition is in the range of 30s to 140s. A method of preparing the hemostatic composition is further disclosed. The composition is configured to control hemorrhage from oozing and pressured bleeding injury any site in human/animal body. 1. A hemostatic hydrogel composition for rapid and synergistic bleeding control comprising:0.01% to 5% of chitosan;0.01% to 0.5% of potassium aluminum sulphate; and0.01% to 0.5% a calcium salt;wherein the clotting time of the composition is in the range of 30s to 140s.2. The composition as claimed in claim 1 , wherein said hydrogel is formed into a shape selected from sponge claim 1 , flexible bandage claim 1 , scaffold claim 1 , injectable gel claim 1 , foam claim 1 , cream and powder form.3. The composition as claimed in claim 1 , wherein said composition is stable in the temperature range 25 to 50° C.4. The composition as claimed in claim 1 , wherein said composition exhibits a hemolytic potential of less than 5 percent.5. The composition as claimed in claim 1 , wherein said composition exhibits an RBC aggregation of at least 0.2.6. The composition as claimed in claim 1 , wherein said composition exhibits a platelet aggregation of at least 0.4.7. The composition as claimed in claim 1 , wherein said composition exhibits an adhesion strength of 6-10 kPa.8. The composition as claimed in claim 1 , wherein the chitosan has molecular weight in the range of 25 kDa to 1000 kDa claim 1 , an average degree of deacetylation between 40% to about 99% and degree of acetylation between 1% to about 70%.9. The composition as ...

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Номер записи: 42
06-02-2020 дата публикации

INJECTABLE HYDROGEL-FORMING POLYMER SOLUTION FOR A RELIABLE EEG MONITORING AND EASY SCALP CLEANING

Номер: US20200037910A1
Автор: FIEDLER Patrique, HAUEISEN Jans, MAGALHÃES DUQUE DA FONSECA José Carlos, OLIVEIRA MARTINS Ana Cristina, TEIXEIRA BATISTA PEDROSA Paulo Eduardo
Принадлежит:

An injectable composition is described, which is capable of forming an hydrogel for electroencephalography (EEG) recording. The obtained hydrogel and method for its production is also an object of the invention, as well as the use of the injectable composition for EEG recording. 1. Injectable hydrogel-forming polymeric composition that is capable of forming a hydrogel for reliable EEG monitoring and an easy scalp cleaning characterized by comprising: a first component , selected from the group consisting of natural and synthetic polymers; a second component , selected from the group consisting of a polymerization initiation system or a cross-linking agent.2. Injectable hydrogel-forming composition according characterized in that the first component is a solution comprising alginate claim 1 , and the second component is a solution comprising calcium salts.3. Injectable hydrogel-forming composition according to characterized in that the first component further comprises at least one ionized salt in a concentration ranging from 0.1% to 10% to provide adequate electrical conductivity.4. Injectable hydrogel-forming composition according to characterized in that the first component further contains a humectant claim 1 , preferably glycerol or propylene glycol claim 1 , and a skin penetration enhancer claim 1 , preferably Tween®80.5. Injectable hydrogel-forming composition according to characterized in that the first component is a solution comprising 2.8% (w/v) sodium alginate claim 1 , 6% (v/v) Tween® 80 claim 1 , 10% (v/v) propylene glycol and 1.8% (w/v) sodium chloride; and the second component is a solution comprising 0.34% (w/v) calcium carbonate claim 1 , 0.14% (w/v) calcium sulfate dehydrate and 1.18% (w/v) gluconolactone.6. Hydrogel for reliable EEG monitoring and easy scalp cleaning claim 1 , formed of the injectable hydrogel-forming composition as claimed in .7. Hydrogel according to characterized in that the gelation rate is adjustable by changing the alginate ...

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Номер записи: 43
16-02-2017 дата публикации

POLYMER-CLAY COMPOSITE AND ORGANOCLAY

Номер: US20170043058A1
Автор: Dawson Jon, Gibbs David, Hilborn Jons, Oreffo Richard, Ossipov Dmitri
Принадлежит: University of Southampton

The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided. 2. The polymer-clay composite material according to claim 1 , further comprising water.3. The polymer-clay composite material according to claim 2 , wherein the polymer-clay composite material is in the form of a hydrogel; orwherein the polymer-clay composite material is in the form of a solid suitable for dissolution in water prior to use.4. The polymer-clay composite material according to any preceding claim claim 2 , wherein the phosphonate ligands comprise or consist of bisphosphonate.5. The polymer-clay composite material according to any preceding claim claim 2 , wherein the linker molecule is anchored to the polymer.6. The polymer-clay composite material according to any preceding claim claim 2 , wherein the phosphonate ligands are anchored to the polymer by covalent bonding.7. The polymer-clay composite material according to any preceding claim claim 2 , wherein the clay nanoparticle comprises or consists of layered silicate.8. The polymer-clay composite material according to any preceding claim claim 2 , wherein the clay nanoparticles are synthetic.9. The polymer-clay composite material according to any preceding claim claim 2 , wherein the clay nanoparticles have an average size of between about 10 nm and about 800 nm in the longest dimension.10. The polymer-clay composite material according to any preceding claim claim 2 , wherein the clay nanoparticles have an average thickness of between about 0.5 and about 2 nm.11. The polymer-clay composite ...

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Номер записи: 44
18-02-2021 дата публикации

Molecular dna strand-displacement controllers for directing material expansion

Номер: US20210047478A1
Автор: Angelo Cangialosi, ChangKyu Yoo, David H. Gracias, Joshua Fern, Rebecca Schulman, Thao D. Nguyen
Принадлежит: JOHNS HOPKINS UNIVERSITY

The present invention is of compositions and methods including modular material controllers that combine amplification with logic, translation of input signals, and response tuning to directly and precisely program dramatic material size changes.

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Номер записи: 45
18-02-2021 дата публикации

HYDROGEL COMPOSITES COMPRISING CHITOSAN AND CELLULOSE NANOFIBERS

Номер: US20210047479A1
Автор: CACHON Thibaut, David Laurent, Montembault Alexandra, OSORIO MADRAZO Anayancy, VIGUIER Eric
Принадлежит:

The present invention relates to an aqueous or hydro-alcoholic suspension of chitosan, dispersed cellulose nanofibers, and an acid, which is suitable for obtaining a hydrogel composite comprising a network of chitosan and cellulose nanofibers. The suspension of the invention is useful for tissue regeneration and the hydrogel of the invention is useful as bioresorbable and biocompatible implant. 1. A suspension suitable for forming a hydrogel composite , said suspension comprising (i) a solvent selected from among water and a mixture of water and an alcohol , and (ii) cellulose nanofibers , chitosan , and an acid dispersed in said solvent , wherein said cellulose nanofibers are not TEMPO-oxidized cellulose nanofibers.2. The suspension according to claim 1 , wherein the amount of cellulose nanofibers dispersed in said solvent ranges from 0.01 to 5 wt.-% and the concentration of chitosan dispersed in said solvent ranges from 1 to 15 wt.-% claim 1 , each based on the total weight of the suspension.3. The suspension according to claim 1 , wherein the chitosan has a molecular weight (Mw) from 400 to 800 kg/mol.4. The suspension according to claim 1 , wherein the pH of said suspension is below 6.5.5. The suspension according to claim 1 , wherein the suspension is a hydro-alcoholic suspension comprising a solvent selected from among a water/propanediol mixture and a water/glycerol mixture.6. The suspension according to claim 1 , wherein said suspension is formulated for use in a method for tissue regeneration.7. (canceled)8. A method for tissue regeneration comprising the step of injecting the suspension of into an osteochondral defect claim 1 , a meniscus/cartilage lesion claim 1 , or other connective tissue lesion to promote tissue regeneration.9. A hydrogel composite obtained by gelation of the suspension according to .10. The hydrogel composite according to claim 9 , where gelation is achieved by neutralizing said suspension.11. The hydrogel composite according to claim ...

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Номер записи: 46
25-02-2016 дата публикации

POLYSACCHARIDE FILM AND METHOD FOR THE PRODUCTION THEREOF

Номер: US20160053061A1
Автор: Beiter Elisabeth, Dürnberger Franz, Kroner Gert, Riedl Gerold, Schweigart Andreas
Принадлежит: Lenzing AG

The present invention relates to a method for the production of films made of polysaccharides which, as a fiber-forming substance, contain α(1→3)-glucan, as well as to the films made thereof and to their use. 1. A method for the production of a polysaccharide film , wherein the finished spinning solution for the extrusion comprises an amine oxide , at least 23% by weight of water , related to the total quantity of the spinning solution , and , as a polysaccharide , α(1→3)-glucan.2. The method according to claim 1 , wherein the amine oxide is N-methylmorpholine-N-oxide.3. The method according to claim 1 , wherein at least 90% of the α(1→3)-glucan consist of hexose units and at least 50% of the hexose units are linked via α(1→3)-glycosidic bonds.4. The method according to claim 1 , wherein the extrusion is carried out by means of a straight slot die or an annular slot die.5. The method according to in claim 1 , wherein the spinning solution is stretched following the extrusion.6. A polysaccharide film comprising a film-forming substance claim 1 , wherein the film-forming substance consists substantially of α(1→3)-glucan.7. The polysaccharide film according to claim 6 , wherein at least 90% of the α(1→3)-glucan consist of hexose units and at least 50% of the hexose units are linked via α(1→3)-glycosidic bonds.8. The polysaccharide film according to claim 6 , wherein the film is oriented at least in one dimension. The present invention relates to a method for the production of films made of polysaccharides which, as a fiber-forming substance, contain □(1□3)-glucan, as well as to the films made thereof and to their use. For the purposes of the present invention, the terms “film” and “sheet” shall be used as being synonymous.Polysaccharides are becoming increasingly important, as they are materials that can be obtained from renewable raw materials. One of the most frequently occurring polysaccharides is cellulose. Cotton fibers, which consist almost exclusively of ...

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Номер записи: 47
23-02-2017 дата публикации

HYDROGELS OF METHACRYLIC HYALURONIC ACID DERIVATIVES FOR ORAL ENZYME THERAPY IN CELIAC DISEASE

Номер: US20170049896A1
Автор: GIAMMONA Gaetano, Palumbo Fabio Salvatore, PITARRESI Giovanna
Принадлежит:

The present invention relates to a composition comprising hydrogels from functionalized hyaluronic acid derivatives, said hydrogels loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP) intended for the oral treatment of celiac disease. Specifically, this invention concerns a one-pot methodology useful to prepare methacrylic derivatives of hyaluronic acid, through the formation of a specific active group on hydroxyl groups of hyaluronic acid, the subsequent substitution of the inserted active group with ethylenediamine and finally, the reaction with methacrylic anhydride. The obtained methacrylic hyaluronic acid derivatives are used to prepare hydrogels through irradiation and loaded with exogenous enzymes selected in the group consisting of prolyl endopeptidase (PEP) and endoprotease (EP). The ability of prepared hydrogels to allow the enzyme release, as active form in simulated gastrointestinal fluids is proved. 1. A composition comprising at least one exogenous enzyme , said enzyme selected in the group consisting of prolyl endopeptidase (PEP) , endoprotease (EP) and combination thereof , said enzyme entrapped in a photocrosslinked methacrylic hyaluronic acid derivatives (HA-EDA-MA) hydrogel , wherein the hyaluronic acid derivatives comprise hyaluronic acid (HA) , or a salt thereof , of molecular weight comprised between 50 ,000 and 1 ,500 ,000 Daltons where at least one hydroxyl group , after activation with a carbonating agent chosen between carbonic phenylesters or haloformic phenylesters , has been functionalised by reaction with ethylenediamine (EDA) and subsequent reaction with methacrylic anhydride (MA).2. The composition according to wherein said enzyme is entrapped in the hydrogel claim 1 , in a concentration between 1 mU/mg and 100 U/mg of polymer.3. The composition according to claim 1 , said composition in form of gel.4. The composition according to claim 1 , said composition in form of ...

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Номер записи: 48
22-02-2018 дата публикации

Porous polymer compound, method of separating compound to be separated, single crystals, method of producing sample for crystal structure analysis, method of determining molecular structure of compound to be analyzed, and method of determining absolute configuration of chiral compound

Номер: US20180051048A1
Автор: Makoto Fujita, Yasuhide Inokuma
Принадлежит: University of Tokyo NUC

The porous polymer compound has a three dimensional skeleton and pores and/or voids that are partitioned and formed by the three dimensional skeleton. The three dimensional skeleton comprises multiple sugar derivatives represented by formula (1) and multiple cations that interact with the hydroxyl groups and/or ether bonds of the sugar derivatives, and the three-dimensional skeleton is formed by each of the cations interacting with two or more sugar derivatives. Also provided are a method of separating a compound to be separated using the porous polymer compound; a single crystal of the porous polymer compound; a method of preparing a sample for crystal structure analysis using the single crystal; a method of determining a molecular structure of a compound to be analyzed using the sample for crystal structure analysis; and a method of determining an absolute configuration of a chiral compound using the sample for crystal structure analysis.

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Номер записи: 49
21-02-2019 дата публикации

TEMPERATURE SENSITIVE HYDROGEL COMPOSITION INCLUDING NUCLEIC ACID AND CHITOSAN

Номер: US20190054015A1
Автор: HONG Cheol Am, KIM Han Gyu, KIM Ik Soo, LEE Su Yeon
Принадлежит: PHARMARESEARCH PRODUCTS CO., LTD.

The present invention provides a temperature sensitive hydrogel composition including a nucleic acid and chitosan. Since the hydrogel has excellent biocompatibility and biostability, and simultaneously has sol-gel phase transition properties depending on temperature changes, the hydrogel is present in a sol state at room temperature and becomes a gel when the hydrogel is injected into the human body or applied on the surface of epithelial skin and the temperature increases. Thus, the temperature-sensitive hydrogel of the present invention can be directly injected into and applied on certain parts requiring treatment and the retention and attaching time of a drug is increased through gelation depending on the temperature so that drug efficacy is sufficiently exhibited. Therefore, it is expected that the temperature-sensitive hydrogel of the present invention can be utilized for various treatments. 1. A temperature-sensitive hydrogel composition containing a nucleic acid and chitosan , wherein the weight ratio of the nucleic acid and the chitosan is 20:1 to 10000:1.2. The temperature-sensitive hydrogel composition of claim 1 , wherein the weight ratio of the nucleic acid and the chitosan is 50:1 to 2000:1.3. The temperature-sensitive hydrogel composition of claim 2 , wherein the weight ratio of the nucleic acid and the chitosan is 100:1 to 1000:1.4. The temperature-sensitive hydrogel composition of claim 1 , wherein the content of the nucleic acid is 0.01 wt % to 3 wt % relative to the total weight of the composition.5. The temperature-sensitive hydrogel composition of claim 4 , wherein the nucleic acid is deoxyribonucleic acid (DNA) claim 4 , ribonucleic acid (RNA) claim 4 , or a mixture thereof.6. The temperature-sensitive hydrogel composition of claim 1 , wherein the content of the chitosan is 1×10wt % to 0.15 wt % relative to the total weight of the composition.7. The temperature-sensitive hydrogel composition of claim 6 , wherein the molecular weight of the ...

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Номер записи: 50
10-03-2022 дата публикации

Cubic cyclodextrin framework-rgd composition and preparation method therefor

Номер: US20220073653A1
Автор: Jian Xu, Jiwen Zhang, LI Wu, Xian Sun, Yaping He, Yong Su
Принадлежит: Shanghai Institute of Materia Medica of CAS

A cubic cyclodextrin framework-RGD composition (RGD-COF) and a preparation method therefor. Specifically, the cyclodextrin framework-RGD composition contains a cyclodextrin framework (COF) having a cubic structure and RGD, and can escape from phagocytosis and clearance of macrophages, enhance migration and adhesiveness to damaged blood vessels, and efficiently target and aggregate activated platelets at damaged blood vessel sites, having application prospects on targeted diagnosis and treatment of diseases associated with uncontrolled hemorrhage, atherosclerosis and cerebral apoplexy. By utilizing the advantage that a cyclodextrin-metal organic framework (CD-MOF) has controllable dimensions, a cubic cyclodextrin framework-RGD composition for nanoscale intravenous injection or microscale topically external use is provided.

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Номер записи: 51
21-02-2019 дата публикации

Method of Preparing Single-Phase Modified Sodium Hyaluronate Gel

Номер: US20190055368A1
Автор: Chen Yan, Feng Xijiang, Sun Weiqing
Принадлежит:

A method of preparing a single-phase modified sodium hyaluronate gel, comprising preparing a sodium hyaluronate solution with a mass fraction between 5% to 15% in an alkaline condition at a pH value between 11 to 14, wherein the sodium hyaluronate has a molecular weight between 1.5 million to 4 million Daltons; adding a cross-linking agent to a solution of step (1), wherein the cross-linking agent and the sodium hyaluronate has a molar ratio between 9% to 15%; rapidly mixing for 20 to 40 minutes to form a gel; allowing to stand after subjecting to a water bath at constant temperature; dialyzing with a dialysis membrane to remove un-reacted cross-linking agent and hydroxide ion; homogenizing; and adding a mobile phase and mixing sufficiently to obtain a high viscosity stabilized single-phase modified sodium hyaluronate gel. 1. A method of preparing a single-phase modified sodium hyaluronate gel , comprising the following steps:(1) preparing a sodium hyaluronate solution with a mass fraction between 5% to 15% in an alkaline condition at a pH value between 11 to 14, wherein the sodium hyaluronate has a molecular weight between 1.5 million to 4 million Daltons;(2) adding a cross-linking agent to a solution of step (1), wherein the cross-linking agent and the sodium hyaluronate has a molar ratio between 9% to 15%; rapidly mixing for 20 to 40 minutes to form a gel;(3) allowing the gel of step (2) to stand after subjecting the gel of step (2) to a water bath at constant temperature;(4) dialyzing the gel of step (3) with a dialysis membrane to remove un-reacted cross-linking agent and hydroxide ion;(5) homogenizing; and(6) adding a mobile phase and mixing sufficiently to obtain a high viscosity stabilized single-phase modified sodium hyaluronate gel.2. The method according to claim 1 , wherein in step (1) claim 1 , the sodium hyaluronate is a sodium hyaluronate produced by bacterial fermentation.3. The method according to claim 1 , wherein in step (1) claim 1 , the alkaline ...

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Номер записи: 52
01-03-2018 дата публикации

DEPOLYMERISATION OF ALGINIC ACID

Номер: US20180057614A1
Автор: AHMED Toqeer, JUUL Anne Grete, Klinger Markus, STENBÆK Dorthe
Принадлежит:

Depolymerisation of alginic acid by microwave treatment. 1. A method of depolymerisation of alginic acid , said method comprising the steps of:(a) providing alginic acid as a starting material for step b, wherein the alginic acid starting material has a pH in the range of 0-4.4 and wherein the dry matter content of the alginic acid starting material is in the range of 15-70% w/w, and(b) treating said alginic acid starting material with microwave irradiation to obtain a depolymerised alginic acid material.2. The method according to claim 1 , wherein the microwave frequency is between 300 MHz and 300 GHz.3. The method according to claim 1 , wherein the concentration of alginic acid in the alginic acid starting material is in the range of 7.5-100% w/w based on dry matter.4. The method according to claim 1 , wherein the alginic acid starting material has a pH in the range of 0-3.5.5. (canceled)6. The method according to claim 1 , wherein the starting alginic acid material has a weight average molecular weight of 1 claim 1 ,500 claim 1 ,000-50 claim 1 ,000 Da.7. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in a mixture with one or more solvents selected from the group consisting of water claim 1 , methanol claim 1 , ethanol claim 1 , and isopropanol.8. The method according to claim 1 , wherein the alginic acid starting material comprises alginic acid in water.9. The method according to claim 1 , wherein the alginic acid starting material further comprises a reducing and/or oxidizing agent.10. The method according to claim 1 , wherein the alginic acid starting material is drained and/or pressed and/or dried before the microwave treatment.11. The method to according to claim 1 , wherein the depolymerised alginic acid material has a weight average molecular weight of 300 claim 1 ,000-2 claim 1 ,000 Da.12. The method according to claim 1 , wherein the depolymerised alginic acid material is further neutralised after the ...

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Номер записи: 53
20-02-2020 дата публикации

HYDROGELS WITH BIODEGRADABLE CROSSLINKING

Номер: US20200054756A1
Автор: ASHLEY Gary W., HENISE Jeffrey C., SANTI Daniel V.
Принадлежит: ProLynx LLC

Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. 1. A method to prepare a drug-releasing degradable hydrogel , which method comprises(a) providing a first multi-armed polymer wherein each arm is terminated by a group comprising orthogonal first and second functional groups, which first orthogonal functional group is different from said second orthogonal functional group;(b) reacting said first multi-armed polymer of (a) with a linker-drug conjugate wherein said conjugate comprises a third functional group that reacts with only the first orthogonal functional group to obtain a derivatized first polymer; and(c) reacting the derivatized first polymer obtained in (b) with a crosslinker coupled to a second multi-armed polymer wherein said crosslinker comprises a fourth functional group that reacts with only the second orthogonal functional group present on said derivatized polymer to obtain said drug-releasing degradable hydrogel, or(d) reacting said first multi-armed polymer of (a) with a crosslinker coupled to a second multi-armed polymer wherein said crosslinker comprises a fourth functional group that reacts only with the second orthogonal functional group to obtain a crosslinked polymer, and(e) reacting the crosslinked polymer of (d) with a linker-drug conjugate, wherein said conjugate comprises a third functional group that reacts with only the first orthogonal functional group to obtain a said drug-releasing degradable hydrogel.2. The method of wherein the linker-drug conjugate is degradable by a beta elimination reaction.4. The method of wherein the crosslinker is degradable by a beta elimination reaction.6. The method of wherein the linker-drug conjugate is of Formula (3).7. The method of wherein each said functional group independently comprises N claim 1 , NH ...

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Номер записи: 54
04-03-2021 дата публикации

STEREOLITHOGRAPHY ELASTIC FILM WITH ADJUSTABLE PEELING FORCE

Номер: US20210061964A1
Автор: Chang Yu-Chen, KUO Tsung-Hua
Принадлежит:

A stereolithography elastic film with adjustable peeling force applied to a stereolithography 3D printing apparatus, and the stereolithography elastic film includes at least one of a first colloid and a second colloid. The first colloid includes a non-polyelectrolyte and water, the water occupies the largest percentage in the first colloid. The second colloid includes a polyelectrolyte, a coagulant and water, the water occupies the largest percentage in the second colloid. The peeling force of the stereolithography elastic film may be adjusted by adjusting the percentage of at least one of the non-polyelectrolyte, the polyelectrolyte, the coagulant, and the water. 1. A stereolithography elastic film with adjustable peeling force applied to a stereolithography 3D printing apparatus , and the stereolithography elastic film comprising:a first colloid including a non-polyelectrolyte and water, the water occupying a largest percentage in the first colloid,wherein a peeling force of the stereolithography elastic film is adjusted by adjusting a percentage of at least one of the non-polyelectrolyte and the water.2. The stereolithography elastic film with adjustable peeling force in claim 1 , wherein the non-poly electrolyte includes an agar.3. The stereolithography elastic film with adjustable peeling force in claim 2 , wherein the percentage of the agar is between 0.3% and 7% claim 2 , and the percentage of the water is between 93% and 99.7%.4. The stereolithography elastic film with adjustable peeling force in claim 3 , wherein the percentage of the agar between is 0.5% and 5% claim 3 , and the percentage of the water is between 95% and 99.5%.5. The stereolithography elastic film with adjustable peeling force in claim 1 , further comprising a third colloid claim 1 , the third colloid including one of locust bean gum (LBG) claim 1 , guar gum and konnyaku.6. The stereolithography elastic film with adjustable peeling force in claim 5 , wherein when the stereolithography ...

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Номер записи: 55
28-02-2019 дата публикации

PROCESS FOR PREPARING A CROSS-LINKED HYALURONIC ACID PRODUCT

Номер: US20190062461A1
Автор: Edsman Katarina, Karlsson Morgan
Принадлежит: GALDERMA S.A.

Efficient cross-linking of hyaluronic acid (HA) is provided by a manufacturing process. In the process, HA is activated by an initial cross-linking in an aqueous solution. Unreacted cross-linking agent is removed from the activated HA. Cross-linking of the activated HA is finalized, without addition of any additional cross-linking agent, in a suspension of a liquid precipitating medium and the activated HA in precipitated form. The resulting cross-linked HA products exhibit high effective cross-linker ratio and other favorable properties, making the products useful as implants and in medical and cosmetic surgery. 111-. (canceled)12. A cross-linked HA product having an effective cross-linker ratio of 35% or higher.1315-. (canceled)16. The cross-linked HA product according to claim 12 , having an effective cross-linker ratio in the range of 35-80%.17. The cross-linked HA product according to claim 12 , having a swelling degree of 4-500 mL per g HA.18. The cross-linked HA product according to claim 17 , having a swelling degree of 15-300 mL per g HA.19. The cross-linked HA product according to claim 12 , wherein the HA product has the shape of particles having a size of 0.1-5.0 mm.20. The cross-linked HA product according to claim 12 , wherein the HA product has the shape of a string claim 12 , a net claim 12 , or a film.21. The cross-linked HA product according to 20 claim 12 , wherein the shape is a string and the string has a ratio between its length and its width of 5:1 or higher.22. The cross-linked HA product according to claim 12 , wherein the HA product is in dried form.23. The cross-linked HA product according to claim 12 , wherein the product is crosslinked with a crosslinking agent selected from the group consisting of 1 claim 12 ,4-butanediol diglycidyl ether (BDDE) claim 12 , 1 claim 12 ,2-ethanediol diglycidyl ether (EDDE) claim 12 , and diepoxyoctane.24. The cross-linked HA product according to claim 12 , wherein the product is ether crosslinked with a ...

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Номер записи: 56
28-02-2019 дата публикации

IMPROVED CURABLE RESIN FOR MINERAL WOOL

Номер: US20190062510A1
Автор: Casado Domínguez Arturo Luís, Castro Cabado María Mercedes, San Román Del Barrio Julio
Принадлежит: URSA Insulation, S.A.

A curable resin and method is disclosed. In one example, the curable resin is for the manufacture of mineral fiber products such as mineral wool insulating products. The curable resin includes components a), b) and c), wherein a) is a saccharide, b) is a polycarboxylic crosslinking agent, and c) is a polyvalent metal oxide curing accelerator. In one example, the curable resin is formaldehyde free. 114-. (canceled)15. A curable resin for the manufacture of mineral wool , comprising components a) , b) and c) , wherein:a) is a saccharide;b) is a polycarboxylic crosslinking agent; andc) is a polyvalent metal oxide.16. The resin of claim 15 , where the resin is formaldehyde free.17. The resin of claim 15 , wherein the polyvalent metal oxide is selected from a group consisting of calcium oxide claim 15 , zinc (II) oxide claim 15 , and mixtures thereof.18. The resin of claim 15 , wherein the amount of the polyvalent metal oxide ranges from 0.5-10 wt.-% in relation to the sum of the weights of the components a) claim 15 , b) and c).19. The resin of claim 15 , wherein the polycarboxylic crosslinking agent is a polycarboxylic compound with a weight average molecular weight <5 claim 15 ,000 g/mol.20. The resin of claim 15 , wherein the polycarboxylic crosslinking agent is selected from the group of citric acid claim 15 , succinic acid claim 15 , tartaric acid claim 15 , maleic acid claim 15 , their corresponding anhydrides claim 15 , the salts thereof claim 15 , and mixtures thereof.21. The resin of claim 15 , wherein the resin is substantially free of polymers from unsaturated carboxylic monomers.22. The resin of claim 15 , further comprising:a polyol different than a saccharide with a molecular weight <400 g/mol, selected from the group of alkene glycol, sugar alcohol, and mixtures thereof.23. The resin of claim 15 , wherein the saccharide is an oligosaccharide or a polysaccharide with a weight average molecular weight of at least 1 claim 15 ,000 g/mol claim 15 , ...

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Номер записи: 57
17-03-2022 дата публикации

METHOD OF CROSSLINKING GLYCOSAMINOGLYCANS

Номер: US20220081519A1
Автор: AUZELY-VELTY Rachel, BOITEAU Jean-Guy, FIGUEIREDO Tamiris, GERFAUD Thibaut, HARRIS Craig Steven, JING JING Laura, TOMAS Loic
Принадлежит:

A new hydrogel made of crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Glycosaminoglycans that are crosslinked via an alkoxyboronate ester anion formed between a diol portion of a diol-functional moiety grafted to a first glycosaminoglycan and a boronate hemiester grafted to a second glycosaminoglycan. 1. A fructose modified hyaluronic acid.3. Crosslinked hyaluronic acids , crosslinked via a phenylboronic acid crosslinker formed between a fructose moiety of a fructose modified hyaluronic acid and a phenylboronic acid grafted to a second hyaluronic acid.5. A method of crosslinking a first hyaluronic acid grafted with a fructose moiety and a second hyaluronic acid grafted with a phenylboronic acid , the method comprising crosslinking the first hyaluronic acid with the second hyaluronic acid by forming a phenylboronic acid crosslinker between the phenylboronic acid of the second hyaluronic acid and the fructose moiety of the first hyaluronic acid grafted with a fructose moiety.7. Crosslinked hyaluronic acids produced according to the method according to .8. Crosslinked hyaluronic acids produced according to the method according to .9. A polymer composition claim 3 , comprising crosslinked hyaluronic acids according to and an aqueous buffer.10. The polymer composition comprising crosslinked hyaluronic acids according to and an aqueous buffer. This application is a continuation application of U.S. Ser. No. 16/322,615 filed Feb. 1, 2019, which application is a U.S. National Stage of PCT/EP2017/069574, filed Aug. 2, 2017, which application claims priority under 35 U.S.C. § 119 of U.S. Provisional Application No. 62/370,479, filed Aug. 3, 2016; and European Patent Application No. 16206624.5, filed Dec. 23, 2016, each hereby expressly incorporated by reference in its entirety and each assigned to the assignee hereof.The ...

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Номер записи: 58
08-03-2018 дата публикации

Photocrosslinked biodegradable hydrogel

Номер: US20180064815A1
Автор: Eben Aslberg, Oju Jeon
Принадлежит: CASE WESTERN RESERVE UNIVERSITY

A photocrosslinked biodegradable hydrogel includes a plurality of natural polymer macromers cross-linked with a plurality of hydrolyzable acrylate cross-links. The hydrogel is cytocompatible and produces substantially non-toxic products upon degradation.

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Номер записи: 59
08-03-2018 дата публикации

Colorimetric Hydrogel Based Nanosensor for Detection of Therapeutic Levels of Ionizing Radiation

Номер: US20180066074A1
Автор: Kaushal Rege
Принадлежит: Arizona Board of Regents of ASU

An apparatus includes a hydrogel including a metallic compound, a surfactant, an acid, agarose and water. The hydrogel is substantially colorless. A radiated hydrogel having a color is formed when the hydrogel receives a low dose of ionizing radiation.

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Номер записи: 60
11-03-2021 дата публикации

HYDROGEL MEMBRANE FOR ADHESION PREVENTION

Номер: US20210069388A1
Автор: Mayes Sarah M., Schmidt Christine E., Zawko Scott A.
Принадлежит:

A biocompatible membrane comprised of alginate and hyaluronate. The membrane may be used to prevent unwanted scarring after surgery. The tissue adherence and the rate of bioresorption of the membrane may be modified through an external stimulus comprising a sequestering agent and a viscosity modifier. 1. A system comprising:hyaluronic acid and crosslinked alginate both included in a hydrogel; anda calcium chelator;wherein (a) the alginate is crosslinked with calcium, (b) the hydrogel is configured to increase in transparency in response to applying the calcium chelator to the hydrogel, and (c) the hydrogel is configured to leach the hyaluronic acid in response to applying the calcium chelator to the hydrogel, and (d) the hydrogel is not templated by a crystal.2. The system of claim 2 , wherein the calcium chelator includes at least one of citrate claim 2 , EDTA claim 2 , EGTA claim 2 , BAPTA claim 2 , a phosphate claim 2 , or combinations thereof.3. The system of claim 2 , wherein the hydrogel comprises:a first hydrogel layer comprising the hyaluronic acid and the crosslinked alginate; anda second hydrogel layer comprising collagen and additional hyaluronic acid.4. The system of wherein:the hydrogel comprises a therapeutic agent, the therapeutic agent including at least one of a drug, a pharmaceutical agent, a peptide, a protein, a medicine, a hormone, a macromolecule, or combinations thereof;the hydrogel is configured so the hydrogel's release rate of the therapeutic agent increases in response to applying the calcium chelator to the hydrogel.5. The system of claim 2 , wherein the hydrogel is configured so mucoadhesiveness of the hydrogel increases in response to applying the calcium chelator to the hydrogel.6. The system of wherein the hydrogel consists essentially of the hyaluronic acid claim 5 , the crosslinked alginate claim 5 , and water.7. The system of claim 1 , wherein the hydrogel includes uncrosslinked alginate.8. The system of claim 7 , wherein the ...

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Номер записи: 61
11-03-2021 дата публикации

GUM ARABIC FROM ACACIA SEYAL

Номер: US20210070892A1
Автор: Al-Assaf Saphwan, Lukanowski Johann, Tretzel Joachim
Принадлежит: DÖHLER GMBH

A method for preparing an improved gum arabic comprising the steps of providing a gum arabic from selecting gum arabic having a tannin content >700 ppm (w/w). 1. A method for preparing an improved gum arabic comprising the steps of{'i': 'Acacia seyal', 'providing a gum arabic from'}selecting gum arabic having a tannin content >700 ppm (w/w),wherein the improved gum arabic has improved emulsification performance.2Acacia seyalAcacia seyalseyal, Acacia seyalfistula. The method of claim 1 , wherein the gum arabic from is selected from gum arabic of var. var. and mixtures thereof.3. The method of claim 1 , wherein the tannin content is >750 ppm (w/w) claim 1 , >1000 or >2000 ppm (w/w).4. The method of claim 1 , wherein the gum hasi) a colour Gardner index of at least 2.5, more preferably 2.5-3.0 and even more preferably >3 at 1 wt % in water orii) a colour Gardner index of at least 15, more preferably 15-16 and even more preferably >16 at 20 wt % in water.5. A process for improving gum arabic comprising the steps ofproviding gum arabicpreparing a dispersion of gum arabicadding a phenol source selected from bark, polyphenols, gallic acid, and a second gum arabic,wherein the improved gum arabic has improved emulsification performance and a tannin content >700 ppm (w/w).6Acacia seyalAcacia senegal. The process of wherein the gum arabic is gum arabic of claim 5 , gum arabic of or a mixture thereof.7. The process of wherein the ratio (w/w) of gum arabic:phenol source is 100:1 to 100:5.8. A composition comprisinggum arabican added phenol source selected from bark, polyphenols, gallic acid, and a second gum arabic,wherein the composition has a tannin content >700 ppm (w/w).9Acacia seyalAcacia senegal. The composition of wherein the gum arabic is gum arabic of claim 8 , gum arabic of or a mixture thereof.10Acacia seyalAcacia seyalseyal, Acacia seyalfistula. The composition of wherein the gum arabic from is selected from gum arabic of var. var. and mixtures thereof.11Acacia seyal ...

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Номер записи: 62
11-03-2021 дата публикации

WATER DEGRADABLE FILM CONTAINING HYALURONIC ACID OR SALT THEREOF AND POLYPHENOL COMPOUNDS

Номер: US20210070951A1
Автор: KIM Ki-suk, LEE Jae-Hyeok, PARK Sun-Hyun
Принадлежит:

The present invention relates to a water degradable film comprising hyaluronic acid or a salt thereof and polyphenol compounds. The film of the present invention can transcribe nanofilms in the form of CNT (carbon nanotube), graphene and magnetic particles to various places. The film of the present invention can be dissolved by an aqueous solution or body fluid, and can be effectively used in the medical field since it is non-toxic and biocompatible. The film of the present invention can also be effectively used as a transcript that does not degrade the quality and performance of the device because no residue remains in the electronic device and the existing photolithography process. 1. A water degradable film comprising hyaluronic acid or a salt thereof and polyphenol compounds , wherein the polyphenol compounds are interposed between at least a part of the hyaluronic acid main chains through hydrogen bonding.2. The water degradable film according to claim 1 , wherein the film includes the polyphenol compound in an amount of 0.05 to 10 weight part based on 1 weight part of the hyaluronic acid or its salt.3. The water degradable film according to claim 1 , wherein the polyphenol compound is one or more compounds selected from the group consisting of tannic acid claim 1 , isoflavone claim 1 , catechin claim 1 , curcumin claim 1 , tannin claim 1 , hydroxy benzoic acid claim 1 , hydroxy cinnamic acid claim 1 , flavonoid claim 1 , lignan claim 1 , stilbene claim 1 , caffeic acid claim 1 , chlorogenic acid claim 1 , anthocyan claim 1 , pyrogallol claim 1 , ellagic acid claim 1 , gallic acid claim 1 , theaflavin-3-gallate claim 1 , resveratrol claim 1 , kaempferol claim 1 , quercetin claim 1 , myricetin claim 1 , luteolin claim 1 , delphinidin claim 1 , cyanidin claim 1 , ampelopsin claim 1 , hesperidin claim 1 , aurantinidine claim 1 , europinidin claim 1 , pelargonidin claim 1 , malvidin claim 1 , peonidin claim 1 , petunidin and rosinidin.4. The water degradable film ...

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Номер записи: 63
08-03-2018 дата публикации

ANODE FOR NONAQUEOUS ELECTROLYTE SECONDARY CELL

Номер: US20180069242A1
Автор: ARAKI Mayu, KURIHARA Hitoshi
Принадлежит: TOPPAN PRINTING CO., LTD.

An anode for a nonaqueous electrolyte secondary cell that can improve the cycle characteristics. In the anode for a nonaqueous electrolyte secondary cell, by modifying the surface of an active material with a polymer containing a carboxyl group, followed by bonding to a crosslinking binder, a stable SEI layer is formed and thus a mixture layer with high mechanical strength is provided, thereby better preventing detachment of the active material due to a volume change caused by charging and discharging, and thus providing an electrode for a secondary cell with good cycle characteristics. 1. An anode for a nonaqueous electrolyte secondary cell , comprising:an active material layer of an electrode, including a binder containing: an aqueous polysaccharide polymer having a carboxyl group, and an aqueous polymer having a carboxyl group with a number average molecular weight of 300,000 or less; andwherein crosslinking treatment is applied to the aqueous polysaccharide polymer having a carboxyl group.2. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polysaccharide polymer having a carboxyl group is completely neutralized, andthe aqueous polymer having a carboxyl group is an acidic polymer.3. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polysaccharide polymer having a carboxyl group is a sodium alginate.4. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:the aqueous polymer having a carboxyl group is a polyacrylic acid.5. The anode for a nonaqueous electrolyte secondary cell of claim 1 , wherein:{'sub': 'x', 'the active material in the active material layer of the electrode contains SiO.'} This application is a continuation application filed under 35 U.S.C. §111(a) claiming the benefit under 35 U.S.C. §§120 and 365(c) of International Application No. PCT/JP2016/064466, filed May 16, 2016, which is based upon and claims the benefit of priority of Japanese Patent ...

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Номер записи: 64
16-03-2017 дата публикации

NOVEL HYDROGELS AND METHODS USING SAME

Номер: US20170072096A1
Автор: Marcolongo Michele, PENN Lynn S., Prudnikova Katsiaryna, SCHAUER Caroline, SHA Xue, XU Xiaohe
Принадлежит:

The present invention provides hydrogel-based compositions that are suitable for replacing or supplementing the nucleus pulposus in a subject. The compositions of the invention are useful for treating, ameliorating or reverting degradation of the nucleus pulposus in the subject. The present invention also provides methods of preparing and using such compositions. 1. A composition comprising a polymerizable crosslinker and a scaffold ,wherein the polymerizable crosslinker comprises an oxiranyl group and an alkenyl group, andwherein the scaffold comprises at least one selected from the group consisting of collagen, pectin, carrageenan, poly(L-lysine), gelatin, agarose, dextran sulfate, heparin, polygalacturonic acid, mucin, chondroitin sulfate, hyaluronic acid, chitosan, alginate, alginate sulfate, poly(acrylic acid), poly(methyl methacrylate) (PMMA), poly(vinylsulfonic acid) (PVSA), poly(L-aspartic acid), poly(L-glutamic acid), poly(L-aspartic acid)-grafted-poly(ethylene glycol) (PAA-g-PEG), poly(L-glutamic acid)-grafted-poly(ethylene glycol) (PGA-g-PEG), poly(sodium 4-styrenesulfonate) (PSS), dermatan sulfate, carboxymethyl cellulose (CMC), and any combinations thereof.2. The composition of claim 1 , wherein the scaffold comprises chondroitin sulfate.3. The composition of claim 1 , wherein the crosslinker comprises a glycidyl group.4. The composition of claim 3 , wherein the crosslinker comprises at least one selected from the group consisting of a glycidyl ester claim 3 , amide claim 3 , amine claim 3 , ether claim 3 , thioester claim 3 , sulfonamide claim 3 , and any combinations thereof.5. The composition of claim 4 , wherein the crosslinker comprises at least one selected from the group consisting of glycidyl methacrylate (GMA) claim 4 , glycidyl acrylate claim 4 , allyl glycidyl ether claim 4 , and any combinations thereof.6. The composition of claim 1 , wherein the scaffold and polymerizable crosslinker react to form a derivatized scaffold.7. The composition ...

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Номер записи: 65
24-03-2022 дата публикации

HIGHLY-SWELLABLE POLYMERIC FILMS AND COMPOSITIONS COMPRISING THE SAME

Номер: US20220089823A1
Автор: Hafezi Hooman, Schmidt Raymond
Принадлежит:

Highly-swellable polymeric films are provided. Aspects also include ingestible compositions that include the highly-swellable polymeric film and an ingestible component. Aspects further include methods of making and using the compositions. 139.-. (canceled)40. A device comprising:a framework;a control device coupled to the framework;a partial power source coupled to the control device and configured to provide power to the control device when activated, the partial power source comprising an anode material and a cathode material; anda highly-swellable polymeric film that rapidly swells without disintegrating upon contact with an aqueous medium external to the device, and covers at least one of the anode material and the cathode material;{'claim-text': ['in a first mode of operation, increase shelf-life stability of the device by inhibiting reaction of at least one of the anode material and the cathode material with ambient moisture while the device is in storage; and', {'claim-text': ['swell upon contact with the aqueous medium; and', 'upon swelling, provide conduction between the aqueous medium and at least one of the anode material and the cathode material that the highly-swellable polymeric film is covering.'], '#text': 'in a second mode of operation:'}], '#text': 'wherein the highly-swellable polymeric film is pre-fabricated to:'}41. The device according to claim 40 , wherein the highly-swellable polymeric film rapidly swells to ten times or greater in volume upon contact with the aqueous medium.42. The device according to claim 41 , wherein the highly-swellable polymeric film swells to ten times or greater in volume within one minute or less upon contact with the aqueous medium.43. The device according to claim 40 , wherein the highly-swellable polymeric film is configured to absorb ten grams or more of water per gram of film upon contact the aqueous medium.44. The device according to claim 40 , wherein the highly-swellable polymeric film comprises an ionic ...

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Номер записи: 66
24-03-2022 дата публикации

HYDROPHILIC CYCLODEXTRIN-CONTAINING SILICONE GELS

Номер: US20220089873A1
Автор: BURKE Sarah, Grimm Chelsea, HARTMAN Christian, Mitra Amitabha, Wang Feng, WHITTON Margaret
Принадлежит: Wacker Chemie AG

Solvent-swollen crosslinked silicone gels containing covalently bonded cyclodextrin groups are prepared by hydrosilylation. The swollen gels are storage stable, compatible with water and polar solvents, and display a significant water break effect. 1. A solvent swollen hydrophilic silicone gel composition comprising: (A) optionally, a cyclodextrin reactant comprising a cyclodextrin or cyclodextrin derivative which has been modified to contain an organic group containing aliphatic unsaturation or an organic group containing silicon-bonded hydrogen;', '(B) optionally, an organopolysiloxane having at least one aliphatically unsaturated group;, 'a crosslinked silicone elastomer containing at least one covalently bonded cyclodextrin moiety, prepared by hydrosilylative crosslinking of reactants (A), (B), and (C)'} (C) an organopolysiloxane containing at least one silicon-bonded hydrogen atom, the hydrosilylative crosslinking being effected by hydrosilylating aliphatically unsaturated groups of (A), when present, and (B), by means of silicon-bonded hydrogen atoms of (A), when present, and (C), in the presence of a hydrosilylation catalyst (D), wherein at least one cyclodextrin moiety is present among reactants (A), (B), and (C),', 'and wherein the hydrosilylative crosslinking is conducted in the presence of a swelling solvent, forming a swollen hydrophilic silicone gel or the hydrosilylative crosslinking is conducted without swelling solvent and a crosslinked elastomer formed in the hydrosilylative crosslinking is dispersed into a swelling solvent to form a swollen hydrophilic silicone gel., 'wherein component (B) is not optional when component (A) is not present or where component (A) contains no aliphatic unsaturation;'}2. The solvent swollen hydrophilic silicone gel composition of claim 1 , wherein hydrosilylative crosslinking is effected in the presence of swelling solvent.3. The solvent swollen hydrophilic silicone gel composition of claim 1 , wherein cyclodextrin ...

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Номер записи: 67
05-03-2020 дата публикации

Process for preparing a porous material

Номер: US20200071484A1
Автор: Alberto Bueno MORALES, Dirk Weinrich, Gimmy Alex Fernandez Ramirez, IIka SELMER, Irina Smirnova, Marc Fricke, Pavel GURIKOV, Raman SUBRAHMANYAM, Volker VOGELSANG, Wibke LOELSBERG
Принадлежит: BASF SE

The present invention is directed to a process for preparing a porous material, at least comprising the steps of providing a gel comprising a solvent (S), wherein the solvent (S) has a volume (V1), pressurizing the gel with carbon dioxide at a temperature and a pressure at which carbon dioxide solubilizes in the solvent (S) forming gas-expanded liquid (EL), wherein the gas-expanded liquid (EL) has a volume (V2) and (V2) is greater than (V1); removing supernatant liquid, and drying the gel. The present invention further is directed to the porous material obtained or obtainable according to the process as such as the use of the porous material according to the invention in particular for medical, biomedical and pharmaceutical applications or for thermal insulation.

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Номер записи: 68
18-03-2021 дата публикации

PREPARATION METHOD OF 4D CHITOSAN-BASED THERMOSENSITIVE HYDROGEL

Номер: US20210079170A1
Автор: Dong Yanhan, Fan Yuqiao, Xu Wenhua, ZHANG Lixia
Принадлежит:

Medical material production and preparation, and a preparation method of a 4D chitosan-based thermosensitive hydrogel. First, chitosan is dissolved in acetic acid solution; a chitosan-based thermosensitive hydrogel is printed by a 4D bioprinter and lyophilized after solvent extraction, to obtain lyophilized chitosan; subsequently, aqueous β-sodium glycerophosphate solution is prepared with ultrapure water and β-sodium glycerophosphate, and then aqueous carboxymethyl chitosan solution is prepared with ultrapure water and aqueous β-sodium glycerophosphate solution are charged into and mixed well with aqueous carboxymethyl chitosan solution to prepare a mixture; finally, the lyophilized chitosan is crosslinked with the mixture to obtain the 4D chitosan-based thermosensitive hydrogel. With scientific and reliable principles thereof, the present invention solves a problem that conventional thermosensitive hydrogels have uneven pore sizes, and improves the entrapment efficiency and ability of limbal stem cells. 1. A preparation method of a 4D chitosan-based thermosensitive hydrogel , comprising the following steps:(1) at room temperature, weighing chitosan, dissolving the chitosan in acetic acid solution, stirring until the chitosan has completely dissolved, to obtain a chitosan solution; using a 4D bioprinter to print the chitosan solution into a chitosan-based thermosensitive hydrogel with a pore size of 50 to 100 μm according to preset print parameters, and shaping the chitosan-based thermosensitive hydrogel as desired; lyophilizing after solvent extraction, to obtain lyophilized chitosan;(2) charging ultrapure water and β-sodium glycerophosphate into a water bath kettle at 60 to 70° C.; after dissolution of β-sodium glycerophosphate, naturally cooling to room temperature to obtain an aqueous β-sodium glycerophosphate solution;(3) preparing an aqueous carboxymethyl chitosan solution with ultrapure water at room temperature, dripping the aqueous β-sodium ...

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Номер записи: 69
24-03-2016 дата публикации

WATER-SOLUBLE HYALURONIC ACID GEL AND METHOD FOR PRODUCING SAME

Номер: US20160081906A1
Автор: Yoneto Kunio
Принадлежит: RITAPHARMA, CO., LTD.

To provide a water-soluble hyaluronic acid gel which does not contain a large amount of an organic solvent, wherein hyaluronic acid is not chemically modified. 1. A water-soluble hyaluronic acid gel comprising hyaluronic acid , a polyhydric alcohol , an acid and 0 to 10% by mass of a water-soluble organic solvent.2. The water-soluble hyaluronic acid gel according to claim 1 , wherein an aqueous hyaluronic acid solution has a pH value falling within the range from 1.9 to 5.2 claim 1 , in which the aqueous hyaluronic acid solution is prepared by dissolving the components to be contained in the water-soluble hyaluronic acid gel claim 1 , except the polyhydric alcohol and water claim 1 , in water in such a manner that 200 parts by mass of water is contained relative to 1 part by mass of hyaluronic acid contained in the water-soluble hyaluronic acid gel.3. The water-soluble hyaluronic acid gel according to claim 1 , wherein the content of hyaluronic acid is 0.04 to 50% by mass.4. The water-soluble hyaluronic acid gel according to claim 1 , wherein the polyhydric alcohol is contained in an amount of 1 to 2000 parts by mass inclusive relative to 1 part by mass of hyaluronic acid.5. The water-soluble hyaluronic acid gel according to claim 1 , wherein water is contained in an amount of 700 parts by mass or less relative to 1 part by mass of hyaluronic acid.6. The water-soluble hyaluronic acid gel according to claim 1 , wherein the polyhydric alcohol comprises glycerin and a polyhydric alcohol other than glycerin at a ratio of 30:10 to 4:36 by mass.7. The water-soluble hyaluronic acid gel according to claim 6 , wherein an aqueous hyaluronic acid solution has a pH value falling within the range from 4.2 to 5.2 claim 6 , in which the aqueous hyaluronic acid solution is prepared by dissolving the components to be contained in the water-soluble hyaluronic acid gel claim 6 , except the polyhydric alcohol and water claim 6 , in water in such a manner that 200 parts by mass of water ...

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Номер записи: 70
23-03-2017 дата публикации

PROCESS FOR PRODUCING POROUS ALGINATE-BASED AEROGELS

Номер: US20170081494A1
Автор: FRICKE Marc, Gurikov Pavel, Loelsberg Wibke, Smirnova Irina, Subrahmanyam Raman, Weinrich Dirk
Принадлежит: BASF SE

The present invention relates to a process for preparing a porous material, at least comprising the steps of providing a mixture (I) comprising a water soluble polysaccharide, at least one compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and water, and preparing a gel (A) comprising exposing mixture (I) to carbon dioxide at a pressure in the range of from 20 to 100 bar for a time sufficient to form a gel (A), and depressurizing the gel (A). Gel (A) subsequently is exposed to a water miscible solvent (L) to obtain a gel (B), which is dried. The invention further relates to the porous materials which can be obtained in this way and the use of the porous materials as thermal insulation material, for cosmetic applications, for biomedical applications or for pharmaceutical applications. 1: A process for preparing a porous material , comprising: (i) a water soluble polysaccharide,', '(ii) a compound suitable to react as cross-linker for the polysaccharide or to release a cross-linker for the polysaccharide, and', '(iii) water;, 'a) providing a mixture (I) comprising'} b1) exposing the mixture (I) to carbon dioxide at a pressure in a range of from 20 to 100 bar for a time sufficient to form a gel (A), and', 'b2) depressurizing the gel (A);, 'b) preparing a gel (A) by a process comprising'}c) exposing the gel (A) to a water miscible solvent (L) to obtain a gel (B); andd) drying of the gel (B).2: The process according to claim 1 , wherein the water soluble polysaccharide is selected from the group consisting of agar claim 1 , alginate claim 1 , carrageenan claim 1 , cellulose claim 1 , hyaluronic acid claim 1 , pectin claim 1 , starch claim 1 , xanthan gum claim 1 , modified cellulose claim 1 , chitin claim 1 , chitosan claim 1 , and a mixture thereof.3: The process according to claim 1 , wherein the water soluble polysaccharide is an alginate.4: The process according to claim 1 , wherein the preparing in ...

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Номер записи: 71
26-03-2015 дата публикации

FORMALDEHYDE-FREE PROTEIN-CONTAINING BINDERS FOR SPUNBOND PRODUCTS

Номер: US20150087783A1
Автор: Alavi Kiarash, Asrar Jawed, Guo Zhihua, Zhang Mingfu
Принадлежит:

One-part binder compositions are described that may include a protein and a crosslinking combination. The crosslinking combination may include at least a first crosslinking compound and a second crosslinking compound. The first and second crosslinking compounds are individually crosslinkable with each other and with the protein. Examples of the protein include soy protein. Fiber products and methods of making the fiber products are also described. The fiber products may include organic fibers, inorganic fibers, or both, in a cured thermoset binder based on solutions of the one-part binder compositions. 1. A one-part binder composition comprising an aqueous mixture of:a protein; and the first and second crosslinking compounds are individually crosslinkable with each other and with the protein,', 'the first crosslinking compound comprises a polycarboxy polymer,', 'the second crosslinking compound comprises a crosslinking agent that comprises a hydroxyl group, and', 'the aqueous solution does not include an emulsion of the first crosslinking compound or the second crosslinking compound., 'an aqueous solution comprising a first crosslinking compound and a second crosslinking compound, wherein2. The one-part binder composition of claim 1 , wherein:the first crosslinking compound comprises a solution polymer.3. The one-part binder composition of claim 1 , wherein the first crosslinking compound comprises a polyacrylic acid.4. The one-part binder composition of claim 1 , wherein the first crosslinking compound comprises a solution polymer compound of styrene and maleic anhydride.5. The one-part binder composition of claim 1 , wherein the second crosslinking compound comprises a polyol.6. The one-part binder composition of claim 5 , wherein the polyol is a polysaccharide.7. The one-part binder composition of claim 6 , wherein the polysaccharide has a dextrose equivalent of 20 or less.8. The one-part binder composition of claim 6 , wherein the polysaccharide is selected from ...

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Номер записи: 72
12-03-2020 дата публикации

POLYMER GEL FILM CONTAINING LIQUID CRYSTAL DROPLETS FOR DETECTING MERCURIC IONS IN WATER AND PREPARATION METHOD THEREOF

Номер: US20200079915A1
Автор: CHANG JUNG-JUNG, Chen Chih-Hsin, Huang Jhih-Wei
Принадлежит:

The invention relates to a method for preparing a polymer gel film containing liquid crystal droplets, comprising the steps of: preparing liquid crystal droplets containing a ligand, by adding a nematic liquid crystal containing a ligand to an aqueous surfactant solution, and mixing, to obtain the liquid crystal droplets containing a ligand; adding the liquid crystal droplets containing a ligand to an aqueous polymer solution, and mixing, to obtain an aqueous polymer solution containing the liquid crystal droplets; and spreading the aqueous polymer solution containing the liquid crystal droplets flatly in a polymer container, and allowing the aqueous polymer solution containing the liquid crystal droplets to gelatinize, to obtain a polymer gel film containing liquid crystal droplets. The invention utilizes liquid crystal droplets dispersed in the agarose to detect mercuric ions in the water, and through the configuration change of the liquid crystal droplets, the mercuric ions is specifically detected. 1. A method for preparing a polymer gel film containing liquid crystal droplets , comprising the steps of:preparing liquid crystal droplets containing a ligand, by adding a nematic liquid crystal containing a ligand to an aqueous surfactant solution, and mixing for 10-30 sec by agitating at a rotation speed of 3000 rpm, to obtain a solution of the liquid crystal droplets containing a ligand;adding the solution of the liquid crystal droplets containing a ligand to an aqueous polymer solution, and mixing by agitating at a rotation speed of 3000 rpm, to obtain an aqueous polymer solution containing the liquid crystal droplets, wherein the ratio of the solution of the liquid crystal droplets containing a ligand to the aqueous polymer solution is 1:1; and{'b': 10', '15, 'spreading the aqueous polymer solution containing the liquid crystal droplets flatly in a polymer container, and allowing the aqueous polymer solution containing the liquid crystal droplets to gelatinize ...

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Номер записи: 73
12-03-2020 дата публикации

POLYSACCHARIDE SUSPENSION, METHOD FOR ITS PREPARATION, AND USE THEREOF

Номер: US20200079932A1
Автор: HAGER Markus, Kroner Gert, Männer Johann, Opietnik Martina, Redlinger Sigrid
Принадлежит:

The present invention relates to a novel stable colloidal polysaccharide suspension containing α(1→3)-glucan, a cost-effective method for its preparation, and possible uses of these polysaccharide suspensions. 1. A phase-stable , colloidal polysaccharide suspension characterized in that the polysaccharide consists at least partly of (1→3)-glucan , that the α(1→3)-glucan was never dried during its preparation , that the suspension was prepared from a press cake having a polysaccharide content between 4 and 80% by weight , preferably between 15 and 45% by weight , and that the polysaccharide concentration of the suspension is between 0.01 and 50% by weight , preferably between 1.0 and 20% by weight.2. A suspension as claimed in claim 1 , characterized in that the (1→3)-glucan content of the polysaccharide is between 1 and 100% by weight claim 1 , more preferably between 80 and 100% by weight.3. A polysaccharide suspension as claimed in claim 1 , wherein at least 90% of the α(1→3)-glucan consist of hexose units and at least 50% of the hexose units are linked via α(1→3)-glycosidic bonds.4. A polysaccharide suspension as claimed in claim 1 , containing apart from the polysaccharide material 1 to 200% by weight claim 1 , related to the polysaccharide quantity claim 1 , in incorporated additives selected from the group comprising pigments claim 1 , titanium oxides claim 1 , especially substoichiometric titanium dioxide claim 1 , barium sulfate claim 1 , ion exchangers claim 1 , polyethylene claim 1 , polypropylene claim 1 , polyester claim 1 , latex claim 1 , activated carbon claim 1 , polymeric superabsorbents claim 1 , and flame retardants.5. A method for preparing a polysaccharide suspension claim 1 , characterized in thata. the base material used is a press cake of an initially moist polysaccharide material consisting at least partly of α(1→3)-glucan,b. the press cake has a solids content between 4 and 80% by weight (related to the entire press cake), preferably ...

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Номер записи: 74
05-05-2022 дата публикации

HYDROGEL COMPOSITION WITH THERMOS-SENSITIVE AND IONIC REVERSIBLE PROPERTIES, CARRIER, METHOD FOR PREPARING AND METHOD OF USE THEREOF

Номер: US20220135748A1
Автор: CHOU Hsiao-Ying, LIN Shuian-Yin, TSAI Hsieh-Chih
Принадлежит:

The present disclosure provides a method for preparing a hydrogel composition with thermos-sensitive and ionic reversible properties and the hydrogel composition prepared by the method. Related application products of the hydrogel composition of the present disclosure include wound dressings, drug carriers, three-dimensional cellular scaffolds, soluble microspheres, and cell capture and release systems, wherein the hydrogel composition with thermos-sensitive and ionic reversible properties has good in vitro and in vivo stability and high biocompatibility, and is non-toxic. The hydrogel composition can be removed and replaced by washing with metal chelating aqueous solution at low temperature.

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Номер записи: 75
05-05-2022 дата публикации

SURGICAL HYDROGEL

Номер: US20220135750A1
Автор: Ghosh Smita, Robinson Simon Rae
Принадлежит:

Disclosed are surgical hydrogels derived from the combination of chitosan derivative and aldehyde-derivatised dextran polymers in combination with a humectant for use as surgical wound packing materials or stents. Also disclosed are sterile kits comprising the precursor components of the surgical hydrogels. Also disclosed are methods of sterilizing the kits and individual components thereof for preparing the hydrogels.

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Номер записи: 76
07-04-2016 дата публикации

Composite materials containing structural polysaccharides and macrocyclic compounds formed from ionic liquid compositions

Номер: US20160096931A1
Автор: Chieu D. Tran
Принадлежит: Marquette University

Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polysaccharides and preferably include macrocyclic compounds. The composite materials may be prepared from ionic liquid compositions comprising the structural polysaccharides and preferably the macrocyclic compounds dissolved in the ionic liquid, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials.

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Номер записи: 77
01-04-2021 дата публикации

Novel crosslinked alginic acid

Номер: US20210095053A1
Автор: Shoji Furusako, Tomohiro Narumi, Tsutomu Satoh
Принадлежит: Mochida Pharmaceutical Co Ltd

The present invention provides alginic acid derivatives represented by formula (I) and formula (II), and a novel crosslinked alginic acid obtained by carrying out a Huisgen reaction using an alginic acid derivative of formula (I) and an alginic acid derivative of formula (II). There are thereby provided novel alginic acid derivatives and a novel crosslinked alginic acid.

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Номер записи: 78
12-05-2022 дата публикации

HYDRO-LIQUID SOLUBLE FILMS, PRODUCTS AND USES THEREOF

Номер: US20220144517A1
Автор: KANGUR Kelly, SALUMÄE Mart
Принадлежит:

Films compositions for packaging and delivering a foodstuff, pharmaceutical, industrial, manufacturing and agricultural materials and uses are disclosed. The film can be formed from at least one biodegradable film forming agent, and at least one biodegradable plasticizer. The resulting film can be formed and shaped to a variety of film package configurations and can have multi compartments. The resulting films and film packages can be edible and substantially and/or completely soluble in a cold, cool, warm and/or hot hydro-liquid including water. The film forming agent(s) is compostable and the film has an essential absence of petrochemicals and non-biodegradable plastics/bioplastics. 1. A film for packaging and delivering a foodstuff(s) or consumable(s) comprising:35-85 wt. % biodegradable film forming agent(s), based on dry film weight;5-60 wt. % biodegradable plasticizer(s), based on dry film weight;wherein the film also contains the foodstuff(s) or consumable(s);wherein the film has an essential absence of petrochemicals and non-biodegradable bioplastics;wherein the film is soluble in one or more of a cold (1-25° C.), cool (25-35° C.), warm (35-50° C.), and hot (50-100° C.) hydro-liquid in 5 seconds to 120 seconds; andwherein the film is compostable.2. The film for packaging of claim 1 , wherein the film forming agent and plasticizer are derived essentially from plant-based materials.3. (canceled)4. The film for packaging of claim 1 , wherein the film encases the foodstuff(s) and/or consumable(s).5. The film for packaging of claim 1 , wherein the biodegradable film forming agent is at least one of pectin claim 1 , carboxymethyl cellulose claim 1 , alginate claim 1 , a polysaccharide claim 1 , hydrolyzed collagen claim 1 , plant-based polyvinyl alcohol (pb-PVOH) claim 1 , casein claim 1 , and derivatives and salts and modified forms thereof.6. The film for packaging of claim 5 , wherein the polysaccharide is at least one of pullulan claim 5 , algin claim 5 , guar ...

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Номер записи: 79
05-04-2018 дата публикации

SELF-INTEGRATING HYDROGELS AND METHODS FOR MAKING THE SAME

Номер: US20180094106A1
Автор: Hou Sen, Ma Peter X.
Принадлежит:

A self-integrating hydrogel includes a water-soluble polymer. The water-soluble polymer includes a repeating unit having at least one functional group that includes an oxygen atom, a sulfur atom, or a nitrogen atom, and a pendant chain covalently attached to the oxygen atom, the sulfur atom, or the nitrogen atom of the at least one functional group of the repeating unit. The pendant chain includes ureido-pyrimidinone. 1. A self-integrating hydrogel , comprising: a repeating unit having at least one functional group that includes an oxygen atom, a sulfur atom, or a nitrogen atom; and', 'a pendant chain covalently attached to the oxygen atom, the sulfur atom, or the nitrogen atom of the at least one functional group of the repeating unit, the pendant chain including ureido-pyrimidinone., 'a water-soluble polymer, including2. The self-integrating hydrogel as defined in wherein the hydrogel does not have a core-shell structure.3. The self-integrating hydrogel as defined in wherein the water-soluble polymer is a modified dextran and the repeating unit contains at least one glucose unit.4. The self-integrating hydrogel as defined in wherein the water-soluble polymer is a modified poly(vinyl alcohol) and the repeating unit is vinyl alcohol.5. The self-integrating hydrogel as defined in wherein the water-soluble polymer is a modified chitosan and the repeating unit is D-glucosamine.6. The self-integrating hydrogel as defined in wherein the water-soluble polymer is a modified cellulose and the repeating unit includes two β(1→4) linked D-glucose units.7. The self-integrating hydrogel as defined in wherein the pendant chain includes an isocyanate that links the ureido-pyrimidinone to the oxygen atom claim 1 , the sulfur atom claim 1 , or the nitrogen atom of the at least one functional group of the repeating unit.8. The self-integrating hydrogel as defined in wherein the pendant chain includes an activated ester claim 1 , an epoxy group claim 1 , or an acyl chloride group that ...

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Номер записи: 80
05-04-2018 дата публикации

HYDROGEL NETWORK

Номер: US20180096751A1
Автор: Bayley John Hagan Pryce, Sapra Kunwar Tanuj
Принадлежит:

The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and a hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices. 1. An electrochemical circuit comprising a hydrogel network , wherein the hydrogel network comprises a plurality of hydrogel objects , wherein each of said hydrogel objects comprises:a hydrogel body,wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects.2. An electrochemical circuit according to wherein each of the hydrogel objects comprises:(a) said hydrogel body, and(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body.3. An electrochemical circuit according to wherein (a) a hydrogel body, and', '(b) an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body,, 'said plurality of hydrogel objects comprises a first hydrogel object and a second hydrogel object, wherein each of the first and second hydrogel objects compriseswherein the first hydrogel object contacts the second hydrogel object to form said interface between the first and second objects.4. An electrochemical circuit according to wherein the interface between the first and second objects comprises a bilayer of amphipathic molecules.5. An electrochemical circuit according to wherein the hydrogel ...

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Номер записи: 81
26-03-2020 дата публикации

Method for Preparing Cross-linked Hyaluronic Acid Gel and Cross-linked Hyaluronic Acid Gel Prepared by the Same

Номер: US20200095383A1
Автор: Sun Weiqing, WANG Weiwei, Zeng Jin
Принадлежит:

Related to is the field of polymer materials, and particularly related to are a method for preparing cross-linked hyaluronic acid gel and a cross-linked hyaluronic acid gel prepared by the method. Under an alkaline condition, a disulfide cross-linking agent is dropwise added into an alkaline solution of hyaluronic acid for cross-linking reaction, and after the reaction is completed, dialysis and freeze drying are carried out to obtain the cross-linked hyaluronic acid gel. A new disulfide cross-linking agent N,N-bis(acroloyl)cystamine is introduced, and it effectively solves degradation regulating problems of cross-linked hyaluronic acid; the disulfide bond ratio is controllable, which can effectively improve a cross-linking modification degree ratio in the cross-linked hyaluronic acid, thereby solving the problem of difficult degradation of highly cross-linked hyaluronic acid gel in the past. The cross-linked material has potential applications in aspects of drug carriers and tissue engineering scaffolds. 1. A method for preparing a cross-linked hyaluronic acid gel , comprising carrying out a cross-linking reaction in an alkaline aqueous solution of hyaluronic acid , wherein N ,N-bis(acroloyl)cystamine is used as a cross-linking agent in the cross-linking reaction.2. The method according to claim 1 , wherein the alkaline aqueous solution of hyaluronic acid is prepared by dissolving hyaluronic acid into an alkaline aqueous solution having a mass percentage of 1%.3. The method according to claim 1 , wherein a mass ratio of hyaluronic acid to the cross-linking agent is (1-30):1.4. The method according to claim 1 , wherein the cross-linking reaction is carried out for 10 to 18 hours.5. The method according to claim 1 , wherein the cross-linking reaction is carried out at a temperature ranging from 40 to 50° C.6. The method according to claim 1 , wherein the cross-linking reaction is completed claim 1 , dialysis and freeze drying are carried out so as to obtain a cross- ...

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Номер записи: 82
12-04-2018 дата публикации

METHOD FOR MANUFACTURING WATER-INSOLUBLE MOLDED ARTICLE AND WATER-INSOLUBLE MOLDED ARTICLE

Номер: US20180100048A1
Автор: ISONO Yasuyuki, NOISHIKI Yasuharu
Принадлежит:

A process for producing a water-insoluble shaped material, including a step of treating a raw material shaped material containing a water-soluble salt of a polyanionic polysaccharide with a treatment liquid containing an acid anhydride to insolubilize the raw material shaped material in water, and the process makes it possible to simply produce a water-insoluble shaped material in which intrinsic characteristics of the polyanionic polysaccharide being a raw material are retained, which has a high safety in that a chemical crosslinking agent is not required, and which is useful as a medical material, a food material, a cosmetic material, and the like. 116-. (canceled)17. A water-insoluble shaped material , comprising polyanionic polysaccharide in an acid form , wherein the treating converts the water-soluble salt of the polyanionic polysaccharide to the polyanionic polysaccharide in an acid form, and', 'the acid anhydride does not form a covalent bond with the polyanionic polysaccharide in the acid form., 'wherein the water-insoluble shaped material is produced by a process comprising: treating a raw material shaped material that comprises a water-soluble salt of the polyanionic polysaccharide, with a treatment liquid comprising an acid anhydride so as to insolubilize the raw material shaped material in water and form the water-insoluble shaped material,'}18. The water-insoluble shaped material according to claim 17 ,wherein the water-insoluble shaped material is dissolved in an aqueous medium having a pH of 12 or higher.19. The water-insoluble shaped material according to claim 17 , being a medical material claim 17 , a food material claim 17 , or a cosmetic material. The present invention relates to a process for producing a water-insoluble shaped material, and also relates to a water-insoluble shaped material, an adhesion inhibitor, an injection material, and a sustained release preparation.It is known that polyanionic polysaccharides such as hyaluronic acid and ...

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Номер записи: 83
08-04-2021 дата публикации

HIGH-PERFORMANCE ANODES FOR LITHIUM ION BATTERIES

Номер: US20210102005A1
Автор: FEI Ling
Принадлежит:

This invention provides a method whereby Si microparticles (“Si MP”) with low cost and nitrogen-abundant chitin fibers from crustacean shells are used as raw materials to produce Si nanoparticles and nitrogen doped carbon composite via a scalable ball milling method. During the ball-milling process, Si MP are downsized, and the chitin fibers are wrapped around the particles. The milled product is then post-thermally treated to obtain Si and nitrogen doped carbon composites. 1. A method for producing anode materials for lithium ion batteries comprising:a. extracting chitin from an arthropod's exoskeleton;b. isolating chitin nanofibrils of said chitin;c. ball milling said chitin nanofibrils with silicon microparticles resulting in a first composite, wherein said silicon microfibers are down-sized resulting in silicon nanoparticles, and wherein said chitin nanofibrils coat the surface of said silicon nanoparticles;d. heat treating said first composite resulting in a final composite.2. The method of wherein said extracting step comprises:a. cleaning and grinding the shell of a crustacean, resulting in a powder;b. removing mineral salts from said powder resulting in a second powder; andc. removing protein from said second powder.3. The method of wherein said removing mineral salts step is performed by treating said powder with a hydrochloric acid solution.4. The method of wherein said removing protein step is performed by treating said second powder with potassium hydroxide.5. The method of wherein said isolating step comprises rinsing and redispersing said extracted chitin in water and then grinding said rinsed claim 1 , redispersed extracted chitin.6. The method of further comprising the step of removing the pigment of said first composite.7. The method of further comprising the step of carbonizing said first composite.8. A composite comprising silicon nanoparticles and chitin fibers.9. A method for producing chitin fibrils-coated silicon nanoparticles comprising ball ...

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Номер записи: 84
04-04-2019 дата публикации

MODIFIED HYALURONIC ACID, METHOD FOR MAKING SAME AND USES THEREOF

Номер: US20190100605A1
Автор: Krause Andreas, LINKO Alexander, VILLAIN Franck
Принадлежит:

The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting. 1. A glycerol-modified hyaluronic acid (HA) derivative or a salt thereof having at least the primary hydroxyl group at the C6 carbon atom of all or a part of the N-acetyl-D-glucosamine units of HA modified into ether-bonded glycerol-containing moieties.2. The HA derivative of claim 1 , wherein said glycerol-containing moiety that is bonded to the C6 carbon atom of HA via an ether bond is a single glycerol residue or a polyglycerol structure of two or more multi-ether-bonded glycerol residues claim 1 , optionally in the form of a dendrimetric hyperbranched polyglycerol structure.3. The HA derivative of claim 1 , wherein the HA derivative is HA or a salt thereof having an average molecular weight of 1.0×10Da to 4.0×10Da and/or wherein the glycerol-containing moieties are linked to the C6 carbon atom of N-acetyl-D-glucosamine units of HA in an amount such that said derivative comprises between 1 and 100 claim 1 , optionally between 5 and 50 claim 1 , of said glycerol-containing moieties per 100 repeating disaccharide unit of the HA.4. A method for making a hyaluronic acid (HA) derivative or a salt thereof as defined in claim 1 , comprising:(a) solubilizing HA in an aqueous alkaline solution to obtain solubilized HA,(b) adding glycidol to the solubilized HA of (a),(c) reacting glycidol and HA to obtain a glycerol-modified HA derivative and,(d) ...

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Номер записи: 85
04-04-2019 дата публикации

ALGINATE HYDROGEL COMPOSITIONS

Номер: US20190100628A1
Автор: Garigapati Venkata R., GARLE Amit, HOSHINO Tetsuo
Принадлежит:

The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof. 1. A semi-permeable hydrogel composition comprising an alginate matrix covalently crosslinked in the periphery of the alginate matrix to a multi-armed water soluble polymer.2. The semi-permeable hydrogel composition of claim 1 , wherein the multi-armed water soluble polymer penetrates the periphery of the alginate matrix.3. The semi-permeable hydrogel composition of claim 1 , wherein the periphery of the alginate matrix is interlocked with and covalently crosslinked to the multi-armed water soluble polymer.4. The semi-permeable hydrogel composition of claim 1 , wherein the hydrogel composition further comprises 1-20 surface layers of alginate that is covalently crosslinked to a multi-armed water soluble polymer.5. The semi-permeable hydrogel composition of claim 1 , wherein the hydrogel composition further comprises a biocompatible surface layer claim 1 , wherein the biocompatible surface layer is covalently bonded to the semi-permeable hydrogel composition.6. (canceled)7. The hydrogel composition of claim 1 , wherein the hydrogel composition is stable for at least 30 days at 40° C. in 1 mM phosphate buffered saline.8. (canceled)9. The hydrogel composition of claim 7 , wherein the composition is characterized by a first tan delta value determined at the time the composition is subjected to storage at 40° C. in 1 mM phosphate buffered saline (day 0) claim 7 , and a second tan delta value determined after the composition has been stored for 30 days at 40° C. in 1 mM phosphate buffered saline; and wherein the first tan delta value and the second tan delta value are the same or differ by no more than about 0.05.10. The hydrogel composition of claim 7 , wherein the hydrogel maintains its semi-permeability after storage for 30 days at 40° C. ...

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Номер записи: 86
02-06-2022 дата публикации

METHOD FOR DEACETYLATION OF BIOPOLYMERS

Номер: US20220169804A1
Автор: Harris Craig, Olsson Johan
Принадлежит: Galderma Holding SA

A method for at least partial deacetylation of a biopolymer comprising acetyl groups, including: a1) providing a biopolymer including acetyl groups; a2) reacting the biopolymer including acetyl groups with hydroxylamine (NHOH) or a salt thereof at a temperature of 100° C. or less for 2-200 hours to form an at least partially deacetylated biopolymer; and a3) recovering the at least partially deacetylated biopolymer. 117.-. (canceled)18. A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules , the method comprising:(a) deacetylating glycosaminoglycans using a hydroxylamine or salt thereof to produce at least partially deacetylated glycosaminoglycans;(b) crosslinking the at least partially deacetylated glycosaminoglycans using a crosslinker, wherein the crosslinking comprises forming amide bonds between activated carboxyl groups of the at least partially deacetylated glycosaminoglycans and nucleophiles on the crosslinker, wherein the crosslinked at least partially deacetylated glycosaminoglycans comprise residual amine groups;(c) re-acylating the crosslinked at least partially deacetylated glycosaminoglycans.19. The method of claim 18 , wherein:the crosslinked at least partially deacetylated glycosaminoglycans comprise ester crosslinks; andthe method further comprises (d) subjecting the re-acylated crosslinked glycosaminoglycans to alkaline treatment to hydrolyze the ester crosslinks.20. The method of claim 18 , wherein the activated carboxyl groups of the at least partially deacetylated glycosaminoglycans in (b) are obtained by: activating carboxyl groups on the at least partially deacetylated glycosaminoglycan with a coupling agent.21. The method of claim 18 , wherein the glycosaminoglycan is selected from the group consisting of hyaluronic acid claim 18 , chondroitin claim 18 , chondroitin sulfate claim 18 , and mixtures thereof.22. The method of claim 18 , wherein the deacetylating in (a) is performed using a hydroxylamine salt ...

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Номер записи: 87
19-04-2018 дата публикации

Self-Supporting, Biodegradable Film Based on Hydrophobized Hyaluronic Acid, Method of Preparation and Use Thereof

Номер: US20180105610A1
Автор: CHMELAR Josef, Dusankova Marcela, Huerta-Angeles Gloria, KAREL Sergej, Minarik Antonin, Nesporova Kristina, Slezingrova Klara, Sulakova Romana, Velebny Vladimir
Принадлежит:

The invention relates to a self-supporting, biodegradable film comprising a C-C-acylated derivative of hyaluronic acid according to the general formula (I), where R is H or Na, and where Ris H or —C(═O)CH, where x is an integer within the range from 9 to 21 and y is an integer within the range from 11 to 43 and CHis a linear or branched, saturated or unsaturated C-Cchain, wherein in at least one repeating unit one or more of Ris —C(═O)CHand where n is within the range from 12 to 4000; a method of preparation thereof and use thereof. 2. The film according to claim 1 , characterized by that it comprises palmitoyl hyaluronan or lauroyl hyaluronan.3. The film according to or claim 1 , characterized by that the C-C-acylated derivative of hyaluronic acid has the molecular weight from 1×10to 1×10g/mol claim 1 , preferably 1×10to 5×10g/mol claim 1 , more preferably 2×10to 3×10g/mol.4. The film according to or claim 1 , characterized by that the C-C-acylated derivative of hyaluronic acid has the substitution degree within the range from 15 to 160% claim 1 , preferably 50 to 100% claim 1 , more preferably 80 to 100%.5. The film according to or claim 1 , characterized by that it has the thickness within the range from 2 to 100 μm claim 1 , preferably within the range from 5 to 25 μm.6. The film according to or claim 1 , characterized by that the surface roughness expressed in the form of a root mean square of at least one of the film surfaces is within the range from 0.5 to 100 nm claim 1 , preferably within the range from 0.5 to 2 nm.7. The film according to or claim 1 , characterized by that it further comprises at least one biologically active substance selected from the group including pharmaceutically active substances and cosmetically active substances claim 1 , preferably vitamins claim 1 , drugs claim 1 , preferably cytostatics claim 1 , steroids claim 1 , further phytoextracts claim 1 , phytocomplexes or phytoactive substances.8. A method of preparation of the film ...

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Номер записи: 88
29-04-2021 дата публикации

Cross-linked Nanoporous Saccharide-based Material and Methods for Fabrication Thereof

Номер: US20210122875A1
Автор: CHENG Dan, LI Jifan, LI Tin Lok, Lin Zhijian, O Wing Nien Wylie
Принадлежит:

The present invention discloses a cross-linked nanoporous saccharide-based material comprising saccharides as building blocks, also referred as nanoporous Nanosponge materials. The reaction of saccharides with cross-linkers at different saccharides to cross-linker ratios in one-pot shall allow formation of nanoporous Nanosponge material. This method further allows introduction of new functional groups on this material by the use of suitable cross-linkers and surface grafting agents, and these functional groups shall be able to provide different interaction forces with water, volatile organic vapors (VOCs) and metal ions. Along with larger inner surface area owing to the presence of nanopores or nanocavities in comparison to porous materials, saccharide-based nanoporous Nanosponge materials shall find broad applications in thermal insulation, water retention, hydrophobic finishes, odor removal properties, and metal ions exchange or absorption from water or soil. The nanoporous Nanosponge materials shall be eco-friendly, biodegradable, and allowing recycle or reuse of spent materials. 2. The cross-linked nanoporous saccharide-based material of claim 1 , wherein said saccharide comprises alpha-glycosidic bond or beta-glycosidic bond.3. The cross-linked nanoporous saccharide-based material of claim 1 , wherein said saccharide is selected from cellulose claim 1 , dextrin or cyclodextrins claim 1 , or the derivatives thereof.4. The cross-linked nanoporous saccharide-based material of claim 3 , wherein n is in a range of 6-8 when said saccharide is selected from cyclodextrins or the derivatives thereof.5. The cross-linked nanoporous saccharide-based material of claim 3 , wherein n is in a range of range of 120 to 1300 when said saccharide is selected from cellulose or the derivatives thereof.6. The cross-linked nanoporous saccharide-based material of claim 3 , wherein said cyclodextrins derivatives are selected from alpha- claim 3 , beta- claim 3 , or gamma-cyclodextrins.7 ...

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Номер записи: 89
26-04-2018 дата публикации

Method for preparing liquid medium composition, and preparation device and kit therefor

Номер: US20180112013A1
Автор: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
Принадлежит: Nissan Chemical Corp

The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.

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Номер записи: 90
09-06-2022 дата публикации

METHOD FOR DEACETYLATION OF BIOPOLYMERS

Номер: US20220177655A1
Автор: HARRIS Craig Steven, Olsson Johan
Принадлежит: Galderma Holding SA

A method for at least partial deacetylation of a biopolymer comprising acetyl groups, including: a1) providing a biopolymer including acetyl groups; a2) reacting the biopolymer including acetyl groups with hydroxylamine (NHOH) or a salt thereof at a temperature of 100° C. or less for 2-200 hours to form an at least partially deacetylated biopolymer; and a3) recovering the at least partially deacetylated biopolymer. 1. A method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules , the method comprising:(a) obtaining a solution comprising an at least first glycosaminoglycan that is a partially deacetylated glycosaminoglycan with a degree of acetylation between 50% and 99% and a second glycosaminoglycan, wherein the second glycosaminoglycan is different from the at least partially deacetylated glycosaminoglycan;(b) activating carboxyl groups on the at least partially deacetylated glycosaminoglycan and/or the second glycosaminoglycan with a coupling agent, to form activated glycosaminoglycans;(c) crosslinking the activated glycosaminoglycans using a crosslinker comprising at least two amine groups solely with amide bonds to provide crosslinked glycosaminoglycans; and(d) acylating residual amine groups of the crosslinked glycosaminoglycans obtained in (c) to form acylated crosslinked glycosaminoglycans; and(e) subjecting the crosslinked glycosaminoglycans provided in (c) or (d) to alkaline treatment to hydrolyze ester crosslinks formed as byproducts during the amide crosslinking in (c),wherein the first and second glycosaminoglycans are not the crosslinker, and wherein the crosslinker comprises a di-, tri-, or tetra-saccharide, oligosaccharide, or polysaccharide.2. The method according to claim 1 , wherein the second glycosaminoglycan is at least partially deacetylated.3. The method according to claim 1 , wherein at least 1% of N-acetyl groups of the first glycosaminoglycan have been converted to free amine groups.4. The method according to ...

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Номер записи: 91
18-04-2019 дата публикации

ELASTOMERIC NANOCOMPOSITE HYDROGELS

Номер: US20190112434A1
Автор: Alsberg Eben, Jeon Oju
Принадлежит:

An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products. 1. A composition comprising:an elastomeric nanocomposite hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles, the elastomeric nanocomposite hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products.2. The composition of claim 1 , wherein the elasticity of the hydrogel is substantially maintained during degradation.3. The composition of claim 1 , wherein the first natural polymer macromers are photocrosslinked with the second natural polymer macromers.4. The composition of claim 3 , wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides claim 3 , which are optionally oxidized.5. The composition of claim 5 , wherein the first natural polymer macromers comprise acrylated and/or methacrylated alginates claim 5 , which are optionally oxidized.6. The composition of claim 5 , wherein the first natural polymer macromers form reversible physical crosslinks with the inorganic nanoparticles.7. The composition of claim 1 , wherein the second natural polymer macromers comprise acrylated and/or methacrylated gelatin.8. The composition of claim 1 , wherein the first natural polymer macromers comprise optionally oxidized acrylated and/or methacrylated polysaccharides and the second natural polymer macromers comprise acrylated and/or methacrylated gelatin and wherein methacrylate and/or acrylate groups of the optionally oxidized acrylated and/or methacrylated polysaccharides react with methacrylate and/or acrylate groups of the acrylated and/or ...

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Номер записи: 92
07-05-2015 дата публикации

Gel-like mass comprising natural or synthetic polymers and method for producing the gel-like mass

Номер: US20150125541A1
Автор: Benjamin Tak Kwong Lee, Edmond Ho Kin Man, Meinrad Flury, Pei Li
Принадлежит: JOKER AG

In a gel-like mass having natural or synthetic polymers, preferably polygalactomannans, at least one cross-linking agent and further ingredients, according to this invention that the at least one cross-linking agent is of amphiphilic core-shell nanoparticles. This invention further refers to a method for producing a gel-like mass, a composition for producing a gel-like mass comprising natural or synthetic polymers, preferably polygalactomannans and amphiphilic core-shell nanoparticles and the use of a gel-like mass as drug delivery system for topical medication.

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Номер записи: 93
25-08-2022 дата публикации

Method for preparing liquid medium composition, and preparation device and kit therefor

Номер: US20220267480A1
Автор: Hisato Hayashi, Koichiro Saruhashi, Tatsuro Kanaki
Принадлежит: Nissan Chemical Corp

The present invention provides a method capable of easily mixing any liquid containing a linking substance such as a divalent metal cation and the like with a liquid containing a particular compound at a high concentration, and capable of producing a liquid medium composition comprising fine structures dispersed therein, and a production device therefor and a kit therefor. The first liquid containing a particular compound is passed through a through-hole having a given cross-sectional area formed in a nozzle part at a given flow rate and injected into the second liquid at a given flow rate. By this simple operation, a structure in which the particular compound is bonded via the linking substance is formed, and the structure is preferably dispersed in a mixture of the both liquids.

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Номер записи: 94
16-04-2020 дата публикации

Coating powdered polymer with a water-soluble dye as an indicator for polymer hydration state

Номер: US20200115510A1
Автор: John Paxton Monsour, Nathan R. Hutchings, Ryan Humphrey
Принадлежит: Proaction Fluids LLC

A method for determining hydration of a polymer includes mixing a water-soluble, powdered dye with a powdered polymer and introducing the mixed water-soluble, powdered dye and powdered polymer into a water-based fluid. Full hydration of the powdered polymer is determined when the mixed water-soluble, powdered dye, powdered polymer and water-based fluid comprises substantially no internal optical contrast.

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Номер записи: 95
27-05-2021 дата публикации

PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID

Номер: US20210155763A1
Автор: Karlsson Morgan
Принадлежит:

A process for manufacturing a cross-linked hyaluronic acid (HA) gel product is comprising the steps of: (a) preparing an aqueous mixture of HA and a cross-linking agent selected from multiepoxides and diepoxides; wherein the HA is dissolved in an aqueous solution containing 1-10% (w/w) inorganic hydroxide; and wherein the dissolved HA constitutes more than 10% (w/w) of the final mixture; and (b) subjecting the aqueous mixture to cross-linking conditions to allow the dissolved HA to react with the cross-linking agent so as to obtain a cross-linked HA gel product. 1. A process for manufacturing a cross-linked hyaluronic acid (HA) gel product , the process comprising: 'wherein the HA is dissolved in an aqueous solution comprising 2-4% (w/w) inorganic hydroxide, and wherein the dissolved HA constitutes 33-35% (w/w) of the aqueous mixture; and', '(a) obtaining an aqueous mixture of HA and a diepoxide crosslinking agent,'} 'wherein the HA is crosslinked in a single step.', '(b) crosslinking the aqueous mixture at 10-75° C. to obtain the crosslinked HA gel product,'}2. The process according to claim 1 , wherein the aqueous solution of (a) comprises 2.1% or more (w/w) inorganic hydroxide.3. The process according to claim 1 , wherein the aqueous solution of (a) comprises 2.5% or more (w/w) inorganic hydroxide.4. The process according to claim 1 , wherein the aqueous mixture of (a) comprises 33% (w/w) HA.5. The process according to claim 1 , wherein the aqueous mixture of (a) comprises 35% (w/w) HA.6. The process according to claim 1 , wherein the crosslinking is performed at 15-35° C.7. The process according to claim 1 , wherein the crosslinking is performed at 20-25° C.8. The process according to claim 1 , wherein the crosslinking occurs at room temperature.9. The process according to claim 1 , wherein the crosslinking is performed for at least 2 hours.10. The process according to claim 1 , wherein the crosslinking is performed for 4-36 h.11. The process according to claim ...

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Номер записи: 96
27-05-2021 дата публикации

NATURAL PACKAGING COMPOSITION

Номер: US20210155777A1
Автор: Cunniffe Julia C., Develter Dirk, HART-COOPER WILLIAM M., Johnson Kaj, KALLA NABEEL N., ORTS WILLIAM J., TORRES LENNARD C.
Принадлежит:

A packaging material composition may be biodegradable and water-soluble. The packaging material may include a biodegradable nonionic polysaccharide, a biodegradable ionic polysaccharide, and a plasticizer. Optionally, additional components may be added to the packaging material for a desired purpose. Additional components may include a biocide, clay, metal oxides (i.e. titanium dioxide and zinc oxide), modified nanoclays, one or more crosslinkers, other functional agents, and residual solvent from the packaging material production process. 1: A packaging composition , comprising:a biodegradable nonionic polysaccharide;a biodegradable ionic polysaccharide; anda plasticizer.2: The packaging composition of claim 1 , wherein said nonionic polysaccharide is at least one of pullulan claim 1 , a pullulan derivative claim 1 , inulin claim 1 , guar claim 1 , cellulose claim 1 , konjac claim 1 , agar claim 1 , agarose claim 1 , curdlan claim 1 , hydroxypropylmethyl cellulose claim 1 , hydroxyethyl cellulose claim 1 , methyl cellulose claim 1 , hydroxypropyl cellulose claim 1 , hydroxypropyl guar claim 1 , cellulose acetate claim 1 , cellulose aldehyde claim 1 , carboxymethyl starch claim 1 , hydroxypropyl starch claim 1 , hydroxyethyl starch claim 1 , starch acetate claim 1 , and starch aldehyde.3: The packaging composition of claim 1 , wherein said ionic polysaccharide is at least one of carboxymethyl cellulose claim 1 , alginate claim 1 , xanthan gum claim 1 , gum arabic claim 1 , gum tragacanth claim 1 , locust bean gum claim 1 , tara gum claim 1 , carboxymethyl starch claim 1 , cationic starch claim 1 , chitosan claim 1 , gelatin claim 1 , gellan claim 1 , pectin claim 1 , and carrageenan.4: The packaging composition of claim 1 , wherein said plasticizer is at least one of sorbitol claim 1 , glycerin claim 1 , polyethylene glycol claim 1 , 1 claim 1 ,2-propanediol claim 1 , 1 claim 1 ,3-propanediol claim 1 , 1 claim 1 ,2-butane diol claim 1 , 1 claim 1 ,3-butane diol ...

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Номер записи: 97
14-05-2015 дата публикации

FILTRATE CONTROL AGENTS IN SOLID FORM

Номер: US20150133346A1
Автор: Cadix Arnaud
Принадлежит:

The present invention relates to a process for preparing control agents for applications in the petroleum field, where a polymer bearing —OH, amine and/or amide functions, which is in the form of a divided solid, is reacted with at least one crosslinking agent bearing at least two —R groups capable of reacting with the —OH, amine or amide groups, under conditions where said polymer remains in solid form and where said crosslinking agent is at least partly in vapour form, The invention also relates to the control agents obtained in solid form according to this process, and also to the mixtures of these solid agents with other additives, which can be used in particular for the preparation of cement grout for oil extraction. 1. A process for the preparation of a fluid loss control agent , in the solid form , comprising a stage (E1) where a polymer carrying several —OH and/or amine and/or amide functional groups , in the form of a divided solid , is reacted with at least one crosslinking agent carrying at least two —R groups capable of reacting with the —OH , amine or amide groups of said polymer under the conditions of said stage (E1) in order to form a covalent bond between the polymer and the crosslinking agent , wherein said stage (E1) being carried out under temperature and pressure conditions where said polymer remains in the solid form and where said crosslinking agent is at least partially in the vapor form , whereby a crosslinking of the polymer within the particles of the divided solid is obtained.2. The process as claimed in claim 1 , the polymer employed in said stage (E1) is a polyvinyl alcohol (PVA).3. The process as claimed in claim 1 , wherein the at least two —R groups present on the crosslinking agent and suitable for forming covalent bonds by reaction with the —OH and/or amide groups of the polymer are aldehyde —CHO groups.4. The process as claimed in claim 3 , wherein the crosslinking agent is glutaraldehyde.5. The process as claimed in claim 1 , ...

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Номер записи: 98
01-09-2022 дата публикации

Material for demineralizing dentin collagen fibril, preparation method and application thereof

Номер: US20220273546A1
Автор: Fan Yu, Jihua CHEN, Jingmei GUO, Kai JIAO, Lina NIU, Zhiming Zheng
Принадлежит: Fourth Military Medical University FMMU

The invention relates to a dentin collagen fibril demineralizing material, and a preparation method and application thereof. The invention relates to a conjugate of water-soluble chitosan and an aminocarboxylic acid metal chelating agent used for dental demineralization, preferably dentin demineralization. The invention also discloses a dentin collagen fibril demineralizing material and a preparation method and application thereof, wherein the material is prepared from 0.5-1 part by mass of water-soluble chitosan, 10-30 parts by mass of EDTA, and 0.8-1.5 parts by mass of cross-linking agent. The invention relates to a dental demineralization composition comprising a conjugate and a material of the invention. The conjugate, material and composition can be used for dentin demineralization treatment before dental bonding and restoration. When used as a dentin collagen demineralizing agent, they have excellent selective extrafibrillar demineralization performance, good biological compatibility, effective anti-bacterial activity, endogenous matrix protease-inhibiting activity and extremely low cytotoxicity.

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Номер записи: 99
11-05-2017 дата публикации

Method For Preparing Chitosan Complex Film

Номер: US20170130016A1
Автор: NI Caihua, Tao Lei, Zhang Liping
Принадлежит:

A method for preparing a chitosan complex film comprises: (1) reacting polyvinyl alcohol-124 with butanedioic anhydride to obtain a modified polyvinyl alcohol; (2) formulating the modified polyvinyl alcohol-124 into a 0.4 wt % aqueous solution, then adding the aqueous solution containing 0.4 wt % of modified polyvinyl alcohol-124 dropwise into an acetic acid solution at a concentration of 0.4 wt % chitosan to obtain a mixed solution; (3) adjusting the pH value of the mixed solution with a 0.01 wt % NaOH solution to pH 5.5, and removing surface bubbles after standing for one hour to obtain a casting solution; (4) pouring the casting solution into a culture dish, placing the culture dish into an oven at 60° C. and drying to a constant weight to obtain the chitosan complex film. The materials used in the method are inexpensive, and the reaction is not complicated, so the cost of the product is not high. 1. A method of preparing a chitosan complex film , the method comprising steps of:(1) obtaining a modified polyvinyl alcohol-124 (PVA-124) by reacting a PVA-124 with a butanedioic anhydride;(2) formulating an aqueous solution containing the modified PVA-124 and adding dropwise the aqueous solution of the modified PVA-124 into an acetic solution containing a chitosan to obtain a mixed solution;(3) adjusting a pH value of the mixed solution to a predetermined value with a NaOH solution;(4) obtaining a casting solution by removing surface bubbles of the mixed solution; and(5) pouring the casting solution into a culture dish and drying the culture dish with the casting solution to obtain a chitosan complex film.2. The method of claim 1 , wherein the step (1) comprises:formulating a first solution containing 20 wt % of the PVA-124 in a dimethylsulfoxide solvent and a second solution containing 20 wt % of the butanedioic anhydride in another dimethylsulfoxide solvent respectively;titrating the second solution containing 20 wt % of the butanedioic anhydride into the first ...

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Номер записи: 100