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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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05-01-2012 дата публикации

Gene expression markers of oncolytic virus sensitivity

Номер: US20120004119A1

Автор: Lynda Chin, Marc Lenburg

Принадлежит: Lynda Chin, Marc Lenburg

A method of predicting an efficacy of an oncolytic virus treatment for a tumor comprises calculating a single-gene predictor score for each of a plurality of genes; calculating a predictor score from the sum of the single-gene predictor scores for the plurality of genes; and predicting, if the predictor score is greater than a predictor score threshold, that the treatment would have efficacy, and if the predictor score is less than a predictor score threshold, that the treatment would lack efficacy. Also, methods of predicting an efficacy of a treatment for a tumor comprise identifying the type and subtype of the tumor, wherein the efficacy of the treatment for the type and subtype of the tumor is known.

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Номер записи: 1

26-01-2012 дата публикации

Genetic markers for risk management of atrial fibrillation and stroke

Номер: US20120021989A1

Автор: Daniel Gudbjartsson, Hilma Holm

Принадлежит: DECODE GENETICS EHF

The invention relates to procedures and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with risk of these conditions. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic 5 methods, uses and procedures for utilizing such susceptibility markers.

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Номер записи: 2

02-02-2012 дата публикации

Method and compositions for cancer prognosis

Номер: US20120027750A1

Автор: Guillaume Cartron, Hervé WATIER

Принадлежит: Centre Hospitalier Regional Universitaire De Tours, UNIVERSITE FRANCOIS RABELAIS DE TOURS

Methods are provided to determine the cancer prognosis of subjects and/or to adapt the treatment protocol of subjects having or susceptible to cancer. Embodiments include the steps of determining in vitro the genotype of said subject at a polymorphism in the C3-ITGAM axis, making a cancer prognosis of the subject based on said genotype and selecting an anti-cancer treatment for the subject.

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Номер записи: 3

02-02-2012 дата публикации

Method for determining a risk, for a subject, of suffering from atopic dermatitis or severity of atopic dermatitis for a subject suffering from atopic dermatitis and method for using a single-nucleotide polymorphism rs12313273 as a biomarker for determining the development or severity of atopic dermatitis

Номер: US20120028827A1

Автор: Chih-Hung Lee, Hsin-Su Yu, Suh-Hang Juo, Wei-Chiao Chang, Wei-Chiao Chen

Принадлежит: KAOHSIUNG MEDICAL UNIVERSITY

The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.

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Номер записи: 4

09-02-2012 дата публикации

Marker for Liver-Cancer Diagnosis and Recurrence and Survival Prediction, a Kit Comprising the Same, and Prognosis Prediction in Liver-Cancer Patients Using the Marker

Номер: US20120034235A1

Автор: Chul Ju Han, Dong Hyoung Lee, Eun Ju LEE, Eun Ran Park, Hyun Jin Shin, Kee Ho Lee, Myoung Jin Park, Pu Hyeon Cha, Sang Bum Kim, Sang Gu Hwang, Seon Rang Woo, Sun Hoo Park, Yong Ho Ham

Принадлежит: Korea Institute of Radiological and Medical Sciences

A composition for detecting a marker for the diagnosis or prognosis of liver cancer is disclosed. The composition includes an agent capable of assessing the expression level of UQCRH (ubiquinol-cytochrome c reductase hinge protein). In addition, a kit having the composition, a microarray for the diagnosis of liver cancer using the marker, and a method for detecting the marker, and predicting recurrence following surgery in liver cancer patients are disclosed. The marker is able to contribute to the early diagnosis of liver cancer and prediction of recurrence following surgery and survival of liver cancer patients who have undergone hepatic resection, and also is significant for being a promising therapeutic target for liver cancer.

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Номер записи: 5

16-02-2012 дата публикации

RBM3 in Testicular Cancer Diagnostics and Prognostics

Номер: US20120040338A1

Автор: Jakob Eberhard, Karin Jirstrom

Принадлежит: Atlas Antibodies AB

The present disclosure provides a method for determining whether a mammalian subject belongs to a first or a second group, wherein subjects of the first group have a higher risk of having a testicular disorder than subjects of the second group, comprising the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA in at least part of an earlier obtained sample comprising biological material from a testicle of said subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; and if said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group. Further, a prognostic method for testicular cancer is provided, as well as means and uses with prognostic and diagnostic applications.

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Номер записи: 6

23-02-2012 дата публикации

Detecting bcl-b expression in cancer and uses thereof

Номер: US20120046195A1

Автор: John C. Reed, Maryla Krajewska

Принадлежит: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer, or gastric cancer.

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Номер записи: 7

01-03-2012 дата публикации

Compositions, Kits, and Methods for Predicting Anti-Cancer Response to Anthracyclines

Номер: US20120052079A1

Автор: Andrea L. Richardson, Zhigang C. Wang

Принадлежит: Dana Farber Cancer Institute Inc

The present invention is based, in part, on the discovery that amplification of human chromosome 8q22-23 regions and over-expression of 8q22-23 genes (e.g., LAPTM4B and YWHAZ) is associated with and predictive of resistance to anthracycline-type chemotherapy. Accordingly, the invention relates to compositions, kits, and methods for predicting the response of cancer cells, e.g., breast, prostate, lung, ovarian, pancreatic, liver, and colon malignancies to anthracyclines.

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Номер записи: 8

01-03-2012 дата публикации

Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies

Номер: US20120052508A1

Автор: Erhan Bilal, Gyan Bhanot, Shrider Ganesan

Принадлежит: Rutgers State University of New Jersey

This application provides a method to identify genetic markers associated with increased sensitivity or resistance to hormonal therapies using an outlier analysis. More specifically, this application discloses that amplifications on chromosomes 8 and 17 are associated with increased proliferation and poor outcome in ER-positive breast cancer, and amplicons 17q21.33-q25.1, 8p11.2 and 8q24.3 may be responsible for higher proliferation and poor outcome in the setting of antiestrogen, in particular Tamoxifen, treatment clinically observed in a subset of ER-positive, HER2-negative breast cancers. The invention also provides use of the identified genetic markers in the development of targeted treatments for antiestrogen-resistant ER-positive breast cancers as well as in improving current methods of drug response prediction.

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Номер записи: 9

01-03-2012 дата публикации

Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy

Номер: US20120053131A1

Автор: Dermot P. McGovern, Jerome I. Rotter, Kent D. Taylor, Stephan R. Targan, Talin Haritunians, Xiuqing Guo

Принадлежит: Cedars Sinai Medical Center

Disclosed are methods of predicting the development of medically refractory ulcerative colitis (MR-UC) in a patient In one embodiment, disclosed is a method of prognosing ulcerative colitis in an individual by determining the presence or absence of one or more risk variants, where the presence of one or more risk variants is indicative of a severe and/or aggressive form of ulcerative colitis. In another embodiment, the severe form of ulcerative colitis is indicative of MR-UC.

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Номер записи: 10

08-03-2012 дата публикации

METHOD OF DIAGNOSING POOR SURVIVAL PROGNOSIS COLON CANCER USING miR-203

Номер: US20120058914A1

Автор: Aaron J. Schetter, Carlo M. Croce, Curtis C. Harris

Принадлежит: Ohio State University Research Foundation, US Department of Health and Human Services

The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.

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Номер записи: 11

15-03-2012 дата публикации

Methods and kits for diagnosing osteoarthritis and predicting progression

Номер: US20120065094A1

Автор: Mukundan Attur, Steven B. Abramson

Принадлежит: New York University NYU

This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.

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Номер записи: 12

22-03-2012 дата публикации

Biomarkers for differentiating melanoma from benign nevus in the skin

Номер: US20120071343A1

Автор: Xiao-Jun Ma, Xingyong Wu, Yuling Luo

Принадлежит: Advanced Cell Diagnostics Inc

Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF 15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma.

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Номер записи: 13

29-03-2012 дата публикации

Methods of predicting complication and surgery in crohn's disease

Номер: US20120073585A1

Автор: Jerome I. Rotter, Kent D. Taylor, Marla Dubinsky, Stephan R. Targan

Принадлежит: Cedars Sinai Medical Center

The present invention relates to prognosing, diagnosing and treating an aggressive form of Crohn's disease characterized by rapid progression to complication and/or surgery from the time of diagnosis. In one embodiment, the prognosis, diagnosis and treatment is based upon the presence of one or more genetic risk factors.

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Номер записи: 14

29-03-2012 дата публикации

Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy

Номер: US20120077687A1

Автор: Christine Buerki, Fadia Saad, Joel Parker, Jonathan C. Schisler

Принадлежит: Individual

The application provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups and for determining the benefit of adjuvant chemotherapy by way of a multigene signature. The application also includes kits and computer products for use in the methods of the application.

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Номер записи: 15

05-04-2012 дата публикации

Expression Levels of COL4A1 and other Markers Correlating with Progression or Non-Progression of Bladder Cancer

Номер: US20120082994A1

Автор: Lars Dyrskjot Andersen, Torben Falck Orntoft

Принадлежит: Individual

Disclosed is determining expression levels protective or harmful markers for bladder cancer prognosis; particularly, determining the expression levels of COL4A3BP alone or in combination with the expression levels of MBNL2, FABP4, and NEK1 or other markers where increased expression levels of these protective markers relative to a control correlates with lack of bladder cancer progression and decreased expression levels correlates with bladder cancer progression or death. Also disclosed is determining the expression levels of COL4A1 alone or in any combination with the expression levels of UBE2C, BIRC5, COL18A1, KPNA2, MSN, ACTA2, and CDC25B or other markers where increased expression levels of these harmful markers relative to a control correlates with bladder cancer progression or death and decreased expression levels correlates with lack of bladder cancer progression Also disclosed are signatures of protective and harmful markers to predict likelihood of bladder cancer progression or non-progression.

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Номер записи: 16

03-05-2012 дата публикации

Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna

Номер: US20120107825A1

Автор: Edward E. Winger, Jane L. REED

Принадлежит: Reed Jane L, Winger Edward E

The invention is directed to methods and compositions for collecting immune cells, preferably peripheral blood mononuclear cells (PBMCs), before or after an intervention, extracting microRNA-comprising RNA from said cells, quantifying microRNAs within the extracted RNA, determining one or more microRNAs that display a bimodal response amongst a statistically sufficient number of patient samples. Patients are then preferably segregated into groups according to their response.

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Номер записи: 17

03-05-2012 дата публикации

ZNF217 A New Prognostic And Predictive Biomarker Of Recurrent Invasive And Metastatic Phenotypes In Breast Cancer

Номер: US20120107826A1

Автор: Julie Vendrell, Pascale Cohen, Pierre Roux

Принадлежит: CENTRE LEON BERARD

The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor sample wherein over-expression of ZNF217 is correlated with likelihood of metastasis and with likelihood of relapse/recurrence of the cancer.

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Номер записи: 18

10-05-2012 дата публикации

Serotonin transporter gene and treatment of alcoholism

Номер: US20120115149A1

Автор: Bankole A. Johnson

Принадлежит: UNIVERSITY OF VIRGINIA PATENT FOUNDATION

The gene (SLC6A4) responsible for encoding the serotonin transporter (SERT) has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on diagnosing variations in the polymorphisms of the SERT gene and expression and activity of the SERT gene, as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders, for monitoring treatment and/or abuse (addictive behavior), and for determining which treatment should be used.

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Номер записи: 19

10-05-2012 дата публикации

Compositions and methods for classifying thyroid nodule disease

Номер: US20120115743A1

Автор: Elai Davicioni, Sam Michael Wiseman

Принадлежит: Individual

A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue.

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Номер записи: 20

17-05-2012 дата публикации

Method for determining predisposition to pulmonary infection

Номер: US20120121593A1

Автор: Christoph Lange, Craig Gerard, Gerald Pier, Hara Levy, Scott Weiss

Принадлежит: Individual

Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.

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Номер записи: 21

17-05-2012 дата публикации

Markers for endometrial cancer

Номер: US20120122726A1

Автор: Andreas Döll, Antonio Gil Moreno, Cristina Perez, Elisabet Rossell, Jaume REVENTÓS PUIGJANER, Miguel Abal Posada, Tamara Maes

Принадлежит: Geadic Biotec AIE

The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.

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Номер записи: 22

24-05-2012 дата публикации

Truncated cd20 protein, deltacd20

Номер: US20120129167A1

Автор: Carole Henry, Christophe Borg, Christophe Ferrand, Marina Deschamps, Pierre Tiberghien, Pierre-Simon Rohrlich

Принадлежит: Francais du Sang Ets

The present invention relates in particular to a protein from an alternative splicing of the gene encoding CD20, the nucleic acid sequences encoding the protein according to the invention, a mutated form of the CD20 gene as well as drugs, diagnostic tools, diagnostic methods and treatment methods using the protein and the nucleic acid sequences according to the invention.

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Номер записи: 23

24-05-2012 дата публикации

Cytokines as prognostic markers of respiratory-tract infection following major surgery

Номер: US20120129176A1

Автор: Dermot Kelleher, Mary White, Owen Ross McManus, Patrick Stordeur, Thomas Ryan, Vincent Young

Принадлежит: College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin

The invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing severe infection such as pneumonia, and respiratory tract infection following surgery. The subset of cytokine markers consists of the interleukin cytokines IL-2, IL-7, IL-23, IL-27, and IL-IO, and Interferon-γ (INFγ) and Tissue Necrosis Factor-α (TNFα). The markers may be employed as individual prognostic variables of infection status, or they may be used in pairs or other combinations. Generally, the abundance of the markers is correlated with infection status by means of an absolute pre-operative value of biomarker abundance, ratio's of pre-operative to post-operative biomarker abundance, or ratio values for pairs of certain biomarkers within the subset. Typically, cytokine abundance is expressed in terms of mRNA copy number wherein the copy numbers are ideally normalised to a house keeping gene and quantification of mRNA copy number is determined by RT-PCR containing reference serial dilutions of cytokine specific cDNA.

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Номер записи: 24

07-06-2012 дата публикации

Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies

Номер: US20120142544A1

Автор: Bettina Heidecker, Joshua M. Hare

Принадлежит: UNIVERSITY OF MIAMI

Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.

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Номер записи: 25

07-06-2012 дата публикации

Diagnosis and treatment of adrenocortical tumors using human microrna-483

Номер: US20120142753A1

Автор: Electron Kebebew, Erin Patterson

Принадлежит: National Institutes of Health NIH, US Department of Health and Human Services

Disclosed herein are methods of diagnosing and treating a malignant adrenocortical tumor, including adrenocortical carcinoma. In some examples, methods of diagnosing a malignant adrenocortical tumor include detecting expression of at least one microRNA (miR) gene product, such as miR-100, miR-125b, miR-195, miR-483-3p, miR-483-5p and IGF2 mRNA in a sample obtained from the subject with an adrenocortical tumor and comparing expression of at least one of these miR gene products and IGF2 mRNA in the sample obtained from the subject to a control. Altered expression of at least one of the miR gene products and IGF2 mRNA, such as a decrease in miR-100, miR-125b or miR-195 or an increase in miR-483-3p, miR-483-5p, and an increase in IGF2 mRNA, in the sample obtained from the subject compared to the control indicates a malignant adrenocortical tumor.

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Номер записи: 26

21-06-2012 дата публикации

Composition for diagnosis of liver metastasis of colorectal cancer and the use thereof

Номер: US20120156681A1

Автор: Ho-Kyung Chun, Woo Yong Lee, Yong Beom Cho

Принадлежит: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

The present invention relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis of colorectal cancer, which comprises either a substance for measuring the mRNA level of CCL7 (Chemokine (C-C motif) ligand 7) gene or a substance for measuring the level of a protein which is encoded by the gene. According to the present invention, whether liver metastasis of colorectal cancer occurred can be diagnosed by measuring the mRNA expression level of the CCL7 gene or the expression level of the CCL7 protein, and the use of the composition comprising an inhibitor of CCL7 gene allows the treatment of colorectal cancer or the liver metastasis of colorectal cancer.

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Номер записи: 27

21-06-2012 дата публикации

miRNA FINGERPRINT IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS

Номер: US20120157337A1

Автор: Andreas Keller, Anne Borries, Eckart Meese, Markus Beier, Peer Friedrich Staehler

Принадлежит: FEBIT HOLDING GMBH

The present invention provides novel methods for diagnosing diseases based on the determination of specific miR-NAs that have altered expression levels in disease states compared to healthy controls.

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Номер записи: 28

28-06-2012 дата публикации

Simultaneous determination of aneuploidy and fetal fraction

Номер: US20120165203A1

Автор: David A. COMSTOCK, Gabrielle HEILEK, Manjula CHINNAPPA, Richard P. Rava, Stephen Quake

Принадлежит: Verinata Health Inc

The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form a pregnant female. The method encompasses the use of sequencing technologies and exploits the occurrence of polymorphisms to provide a streamlined noninvasive process applicable to the practice of prenatal diagnostics.

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Номер записи: 29

05-07-2012 дата публикации

Gene Expression Markers for Colorectal Cancer Prognosis

Номер: US20120171688A1

Автор: Drew Watson, James Hackett, Joffre B. Baker, Kim Clark-Langane, Soonmyung Palk, Wayne Cowens

Принадлежит: Genomic Health Inc, NSABP Foundation Inc

A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the subject.

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Номер записи: 30

05-07-2012 дата публикации

Biomarkers and uses thereof in prognosis and treatment strategies for right-side colon cancer disease and left-side colon cancer disease

Номер: US20120172244A1

Автор: Amanda Hummon, Steven Buechler

Принадлежит: University of Notre Dame

Genetic biomarkers for left side colon cancer (LCC) (such as expression levels of an RNA transcript or expression product of NOX4, MMP3, or a combination) and right side colon cancer (RCC) (such as expression levels of an RNA transcript or expression product of CDCX2, FAM69A, or a combination), are disclosed. Methods for using the biomarkers in providing a prognosis of relapse-free survival probability in patients having LCC or RCC are also presented. Prognostic panels using gene expression values of the biomarkers are also presented. Computer implemented methods employing the biomarkers, and as well as for determining relapse-free survival probability in a patient having RCC or LCC are provided. A genetic method for classifying a colon cancer tissue as a RCC or as a LCC is also disclosed.

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Номер записи: 31

19-07-2012 дата публикации

Pnmt as a novel marker for progenitor cells

Номер: US20120183528A1

Автор: Karl Pfeifer, Steven N. Ebert

Принадлежит: Individual

In certain aspects, the present invention provides methods and compositions relating to a Pnmt-positive progenitor cell. In certain aspects, the present invention relates to methods for isolating and transplanting the subject progenitor cells, and methods for treating diseases such as myocardiac injuries and neurodegenerative disorders.

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Номер записи: 32

26-07-2012 дата публикации

Methods and compositions for determining severity of heart failure in a subject

Номер: US20120190562A1

Автор: Alan S. Go, Choong-Chin Liew, Jun Ma

Принадлежит: Individual

The application provides a method of determining a severity of heart failure in a human test subject, by determining a level of RNA encoded by one or more heart failure marker genes in blood of the test subject compared to controls.

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Номер записи: 33

02-08-2012 дата публикации

Oversampling in a combined transposer filter bank

Номер: US20120195442A1

Автор: Lars Villemoes, Per Ekstrand

Принадлежит: DOLBY INTERNATIONAL AB

The present invention relates to coding of audio signals, and in particular to high frequency reconstruction methods including a frequency domain harmonic transposer. A system and method for generating a high frequency component of a signal from a low frequency component of the signal is described. The system comprises an analysis filter bank ( 501 ) comprising an analysis transformation unit ( 601 ) having a frequency resolution of Δf; and an analysis window ( 611 ) having a duration of D A ; the analysis filter bank ( 501 ) being configured to provide a set of analysis subband signals from the low frequency component of the signal; a nonlinear processing unit ( 502, 650 ) configured to determine a set of synthesis subband signals based on a portion of the set of analysis subband signals, wherein the portion of the set of analysis subband signals is phase shifted by a transposition order T; and a synthesis filter bank ( 504 ) comprising a synthesis transformation unit ( 602 ) having a frequency resolution of QΔf; and a synthesis window ( 612 ) having a duration of D s ; the synthesis filter bank ( 504 ) being configured to generate the high frequency component of the signal from the set of synthesis subband signals; wherein Q is a frequency resolution factor with Q≧1 and smaller than the transposition order T; and wherein the value of the product of the frequency resolution Δf and the duration D A of the analysis filter bank is selected based on the frequency resolution factor Q.

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Номер записи: 34

09-08-2012 дата публикации

Drg11-responsive (dragon) gene family

Номер: US20120204280A1

Автор: Clifford J. Woolf, Tarek A. Samad

Принадлежит: General Hospital Corp

This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.

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Номер записи: 35

06-09-2012 дата публикации

Methods for identifying, diagnosing, and predicting survival of lymphomas

Номер: US20120225793A1

Автор: Andreas Rosenwald, Andreas Zetti, Armando Lopez-Guillermo, Bruce Tan, Dennis Weisenburger, Elaine Jaffe, Elías Campo, Emili Montserrat, Erlend Smeland, George Wright, German Ott, Hans-Konrad Muller-Hermelink, Harald Holte, Itziar Salaverria, James Armitage, Jan Delabie, John I. Powell, Joseph Connors, Julie Vose, Kai Fu, Lisa Rimsza, Louis M. Staudt, Randy Gascoyne, Richard I. Fisher, Sandeep Dave, Silvia M. Bea, Stein Kvaloy, T. Andrew Lister, Thomas Grogan, Thomas Miller, Timothy C. Greiner, Victor Moreno, Wing C. Chan, Wyndham Wilson

Принадлежит: Arizona Board of Regents of University of Arizona, British Columbia Cancer Agency BCCA, Fundacio Clinic per a la Recerca Biomedica FCRB, HOSPITAL CLINIC DE BARCELONA, Julius Maximilians Universitaet Wuerzburg, OSLO UNIVERSITETSSYKEHUS HF, QUEEN MARY AND WESTFILED COLLEGE UNIVERSITY OF LONDON, Universitat de Barcelona UB, University of Nebraska, UNIVERSITY OF ROCHESTER, US Department of Health and Human Services

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

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Номер записи: 36

13-09-2012 дата публикации

Compositions and methods for prognosis and treatment of prostate cancer

Номер: US20120232124A1

Автор: Ayelet Chajut, Shai Rosenwald

Принадлежит: Rosetta Genomics Ltd

Described herein are compositions and methods for prognosis and treatment of prostate cancer patients. Specifically the invention relates to microRNA molecules associated with the prognosis of prostate cancer, as well as various nucleic acid molecules relating thereto or derived therefrom.

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Номер записи: 37

20-09-2012 дата публикации

Novel tumor marker determination

Номер: US20120238458A1

Автор: Dan CACSIRE CASTILLO-TONG, Dietmar Pils, Eva Obermayr, Robert Zeillinger

Принадлежит: Individual

A method of determining gynaecologic tumor disease in a subject by providing a sample of peripheral blood of the subject, measuring the PPIC expression of cells in the sample, and comparing this to a reference value, the PPIC overexpression being indicative of a gynecologic tumor disease and/or disease progression, including metastatic potential in a gynecologic cancer patient.

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Номер записи: 38

11-10-2012 дата публикации

Treatment of cancer and compositions

Номер: US20120258056A1

Автор: Richard Essner

Принадлежит: JOHN WAYNE CANCER INSTITUTE

The invention discloses a method of identifying a gene associated with stage III primary cancer or lymph node metastasis. The genes so identified include CAV1, CST3, LIMK1, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPIN1. Also disclosed are methods for diagnosis, prognosis, and treatment of cancer. The invention further discloses compositions for preventing and treating diseases.

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Номер записи: 39

11-10-2012 дата публикации

Treatment and Prevention of Dengue Virus Infections

Номер: US20120258079A1

Автор: Chelsea M. Byrd, Dennis E. Hruby, Dongcheng Dai, Robert Jordan

Принадлежит: Individual

Methods and pharmaceutical compositions for treating viral infections, by administering certain 2 -aryl-benzothiazole or 2 -heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.

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Номер записи: 40

18-10-2012 дата публикации

Simultaneous detection of mutational status and gene copy number

Номер: US20120264127A1

Автор: Edmundo David Del Valle, Fabien Gaire, Hiro Nitta, Shalini Singh

Принадлежит: Ventana Medical Systems Inc

The present invention provides compositions and methods for simultaneously detecting mutational status and gene copy number. In particular, the present invention provides simultaneous measurement of gene copy number and detection of the L858R and Exon 19 del mutations in a tissue sample.

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Номер записи: 41

15-11-2012 дата публикации

Detecting analytes

Номер: US20120285829A1

Автор: Andrew Mount, Ilenia Ciani, Mizanur Khondoker, Peter Ghazal, Till Bachmann

Принадлежит: ITI Scotland Ltd

Provided is a method for detecting an analyte, which method comprises: a) applying an alternating voltage to the analyte, wherein the alternating voltage comprises a plurality of superimposed frequencies sufficient to distinguish the presence of the analyte by electrochemical impedance spectrometry (EIS); and b) determining the identity and/or quantity of the analyte from EIS data.

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Номер записи: 42

15-11-2012 дата публикации

Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer

Номер: US20120288861A1

Автор: Heinz-Josef Lenz

Принадлежит: Individual

This disclosure provides compositions and methods for determining the likely tumor recurrence of gastric cancer patients based on genomic polymorphisms of the SPARC gene. The disclosure also provides compositions and methods for selecting gastric cancer patients for appropriate treatments and methods of treating them.

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Номер записи: 43

22-11-2012 дата публикации

Method for the in vitro diagnosis of bronchopulmonary carcinoma by detection of major alternative transcripts of the klk8 gene encoding kallicrein 8 and use thereof for prognosticating survival

Номер: US20120295261A1

Автор: Chris Planque, Colette Jolivet-Reynaud, Mireille Ainciburu, Yves Courty

Принадлежит: bioMerieux SA, UNIVERSITE FRANCOIS RABELAIS DE TOURS

A method for the in vitro diagnosis of bronchopulmonary carcinoma, in particular of non-small cell bronchial carcinoma, that includes a stage of detecting, in a biological sample derived from a patient suspected to be suffering from bronchopulmonary carcinoma, at least one of the major alternative transcripts of the KLK8 gene encoding kallikrein 8. This method is particularly useful for the survival prognostication of patients suffering from bronchopulmonary carcinoma.

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Номер записи: 44

22-11-2012 дата публикации

Non-Invasive Diagnosis of Graft Rejection in Organ Transplant Patients

Номер: US20120295810A1

Автор: Hannah Valantine, Stephen R. Quake, Thomas M. Snyder

Принадлежит: Leland Stanford Junior University

The disclosure provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. The methods comprise determining the presence or absence of one or more nucleic acids from a donor transplant, wherein said one or more nucleic acids from said donor are identified based on a predetermined marker profile, and diagnosing or predicting transplant status or outcome based on the presence or absence of said one or more nucleic acids.

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Номер записи: 45

13-12-2012 дата публикации

Tumor suppressor designated ts10q23.3

Номер: US20120315631A1

Автор: Alfred W.K. Yung, Mark A. Pershouse, Peter Steck, Samar A. Jasser, Sean V. Tavtigian

Принадлежит: Myriad Genetics Inc, University of Texas System

A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel 47 kD protein. A domain of this product has an exact match to the conserved catalytic domain of protein tyrosine phosphatases, indicating a possible functional role in phosphorylation events. Sequence analyses demonstrated the a number of exons of the gene were deleted in tumor cell lines used to define the 10q23.3 region, leading to the classification of this gene as a tumor suppressor. Further analyses have demonstrated the presence of a number of mutations in the gene in both glioma and prostate carcinoma cells. Methods for diagnosing and treating cancers related to this tumor suppressor, designated as TS10q23.3, also are disclosed.

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Номер записи: 46

20-12-2012 дата публикации

Predicting benefit of anti-cancer therapy via array comparative genomic hybridization

Номер: US20120322677A1

Автор: Marieke Anne Vollebergh, Petra Marleen Nederlof, Sabine Charlotte Linn

Принадлежит: Stichting Het Nederlands Kanker Instituut

Array comparative genomic hybridization classifiers, arrays comprising the classifiers, and related methods of using the same for predicting the therapeutic efficacy of anti-cancer therapy by detecting phenotypic genetic traits using comparative genomic hybridization are disclosed.

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Номер записи: 47

10-01-2013 дата публикации

Diagnostic and Prognostic Markers for Cancer

Номер: US20130012409A1

Автор: Frank M., Lance Miller, Suzy V. Torti

Принадлежит: Wake Forest University Health Sciences

Compositions and methods useful for diagnosis and prognosis of cancer are provided.

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Номер записи: 48

10-01-2013 дата публикации

Methods and materials for detecting colorectal cancer and adenoma

Номер: US20130012410A1

Автор: David A. Ahlquist, Hongzhi Zou

Принадлежит: Mayo Foundation for Medical Education and Research

The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal.

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Номер записи: 49

10-01-2013 дата публикации

Marker for diagnosis of breast cancer, test method, and test kit

Номер: US20130012412A1

Автор: Kosuke Oikawa, Masahiko Kuroda, Masakatsu Takanashi, Masami Tanaka, Takayuki Mizutani

Принадлежит: KONICA MINOLTA INC, MIRACURE Inc

An embodiment of the present invention provides a marker, a test method, and a test kit which can detect the onset of breast cancer that cannot be detected by palpation or mammography examination or breast cancer in an early stage (clinical stage 0), which are simple, and which have high reliability. A marker associated with breast cancer of an embodiment of the present invention is characterized by being a micro-RNA that is found in serum or plasma. More specifically, the marker contains at least a micro-RNA that is present in the serum or the plasma at a significantly reduced level after the onset of breast cancer, or during or after an early stage (during or after clinical stage 0) of breast cancer compared with that before the onset of breast cancer or before the early stage (before clinical stage 0) of breast cancer.

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Номер записи: 50

17-01-2013 дата публикации

Single nucleotide polymorphism for predicting prognosis of hepatocellular carcinoma

Номер: US20130017975A1

Автор: Dan-Bi Lee, Eun Sil Yu, Jeong A Kim, Jong-Eun Lee, Neung Hwa Park, Sae-Hwan Lee, Young Hwa Chung, Young-Joo Lee

Принадлежит: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Single nucleotide polymorphisms (SNP) for predicting prognosis of hepatocellular carcinoma after curative surgical resection are provided. The SNPs have a significant correlation with an over-expression of MTA1 which is useful prognostic factor for prediction of prognosis or poor survival after curative surgical resection of hepatocellular carcinoma. Therefore, the SNPs can be used in developing micro-arrays or test kits for prediction of the prognosis of hepatocellular carcinoma, and in screening drugs to improve poor prognosis of hepatocellular carcinoma after curative surgical resection.

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Номер записи: 51

24-01-2013 дата публикации

Methods of diagnosing endometriosis

Номер: US20130022593A1

Автор: Linda C. Giudice

Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis.

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Номер записи: 52

24-01-2013 дата публикации

Methods for assessing genomic instabilities in tumors

Номер: US20130023427A1

Автор: Andy Hu, Anthony P. Shuber, Thomas C. Meyers

Принадлежит: Predictive Biosciences Inc

The invention generally relates to methods for assessing genomic instabilities in a tumor sample. The invention may further be used to predict grade, stage, and prognosis of cancer in a patient. The invention further relates to cataloging the efficacy of therapeutics on specific genomic instabilities and generating a personalized therapeutic regimen for a cancer patient based upon their genomic instabilities.

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Номер записи: 53

24-01-2013 дата публикации

Methods of Assessing Chromosomal Instabilities

Номер: US20130023431A1

Автор: Anthony P. Shuber

Принадлежит: Predictive Biosciences Inc

Method of assessing or quantifying chromosomal instability in a subject, wherein the sample is obtained from an effluent, lavage, or organ wash. Methods of obtaining a whole genome sequence from an effluent, lavage, or organ wash.

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Номер записи: 54

24-01-2013 дата публикации

Identification of Tumors

Номер: US20130023441A1

Автор: Mark G. Erlander, Xiao-Jun Ma

Принадлежит: Biotheranostics Inc

The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.

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Номер записи: 55

31-01-2013 дата публикации

Compositions and methods for determing cancer susceptibility

Номер: US20130029926A1

Автор: Jennifer Potter, Jerry Lanchbury, Kirsten Timms

Принадлежит: Myriad Genetics Inc

The invention generally relates to a molecular classification of disease and particularly to molecular markers for cancer susceptibility and methods of use thereof. More specifically, the invention relates to the determination, screening, or classification of an individual's genetic risk for breast and ovarian cancer susceptibility.

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Номер записи: 56

14-02-2013 дата публикации

Prognostic markers and methods for prostate cancer

Номер: US20130039908A1

Автор: Eddie Reed, Rui Gao, William Douglas FIGG

Принадлежит: UNIVERSITY OF SOUTH ALABAMA

The present invention relates to methods and compositions for the diagnosis, prognosis and treatment of neoplastic disorders. Some embodiments include methods, compositions, and kits for the prognosis and treatment of prostate cancer.

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Номер записи: 57

28-02-2013 дата публикации

Plasma Carboxypeptidase B as a Predictor for Disease Severity and Response

Номер: US20130052186A1

Автор: Jungsik Song, William H. Robinson

Принадлежит: Leland Stanford Junior University, US Department of Veterans Affairs VA

Compositions and methods are provided for prognostic classification of individuals into groups that are informative of the individual's likelihood of developing severe disease associated with undesirable complement activation. Individuals having one or both alleles for a more stable or active carboxypeptidase B variant have a reduced propensity for developing severe disease. The presence of the protective variant may be identified through any suitable method.

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Номер записи: 58

28-02-2013 дата публикации

Mirna fingerprint in the diagnosis of prostate cancer

Номер: US20130053264A1

Автор: Andreas Keller, Anne Borries, Eckart Meese, Markus Beier

Принадлежит: FEBIT HOLDING GMBH

MicroRNAs (miRNA) are a recently discovered class of small non-coding RNAs (17-14 nucleotides). Due to their function as regulators of gene expression they play a critical role both in physiological and in pathological processes, such as cancer. The present invention provides novel methods for diagnosing a state of health based on the determination of specific miRNAs that have altered expression levels in different conditions, e.g. disease states compared to healthy controls.

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Номер записи: 59

07-03-2013 дата публикации

Hypoxia-related gene signatures for cancer classification

Номер: US20130058924A1

Автор: Alexander Gutin, Srikanth Jammulapati, Susanne Wagner

Принадлежит: Myriad Genetics Inc

Biomarkers, particularly hypoxia-related genes, and methods using the biomarkers for molecular detection and classification of disease are provided.

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Номер записи: 60

07-03-2013 дата публикации

Cdkn2a as a prognostic marker in bladder cancer

Номер: US20130059303A1

Автор: François RADVANYI

Принадлежит: Individual

The present invention provides methods for predicting clinical outcome and for providing information for determining follow-up strategy of a subject affected with a non-muscle invasive bladder cancer, as well as a method for selecting a subject affected with a non-muscle invasive bladder cancer for an anti-tumoral therapy. The present invention also provides kits for implementing these methods.

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Номер записи: 61

21-03-2013 дата публикации

Methods for autoimmune disease diagnosis, prognosis, and treatment`

Номер: US20130071860A1

Автор: Garry P. Nolan, Jason Ptacek, Matthew B. Hale

Принадлежит: Leland Stanford Junior University

In one aspect, the present invention provides methods for the classification, diagnosis, prognosis, theranosis, and/or prediction of an outcome of an autoimmune disease in a subject.

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Номер записи: 62

21-03-2013 дата публикации

Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer

Номер: US20130072392A1

Автор: Cameron Brennan, Giovanni Tonon, John D. Shaughnessy, JR., Kenneth C. Anderson, Lynda Chin, Ronald A. DePinho, Ruben D. Carrasco

Принадлежит: Dana Farber Cancer Institute Inc, University of Arkansas

The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.

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Номер записи: 63

21-03-2013 дата публикации

Method and kit for discriminating between breast cancer and benign breast disease

Номер: US20130072399A1

Автор: Bruno Mougin, Fei Wu, Qinghua Xu, Xia Meng, Xun Ye

Принадлежит: bioMerieux SA

A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene including a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.

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Номер записи: 64

28-03-2013 дата публикации

Means and Methods for Determining Risk of Cardiovascular Disease

Номер: US20130079384A1

Автор: Esther Elisa Johanna Maria Creemers, Sara Johanna Pinto-Sietsma

Принадлежит: Academisch Medisch Centrum bij de Universiteit van Amsterdam

The invention relates to medicine, in particular to internal medicine and/or cardiology. The present invention provides means and methods for typing a sample and identifying and/or treating a patient suffering from or at risk of suffering from cardiovascular disease by measuring mi RNA present in a sample of said patient. The present invention further provides means and methods for identifying new cardiovascular disease therapies.

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Номер записи: 65

23-05-2013 дата публикации

Method for analyzing d4z4 tandem repeat arrays of nucleic acid and kit therefore

Номер: US20130130924A1

Автор: Aaron Bensimon, Anne Vannier, Nicolas Levy, Pierre Walrafen

Принадлежит: Individual

The present invention relates to a method for analysing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.

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Номер записи: 66

30-05-2013 дата публикации

Newly identified colon cancer marker and diagnostic kit using the same

Номер: US20130137603A1

Автор: Hee Young Yang, Joseph Kwon, Kyoung Jin Chung, Tae Hoon Lee, Young Kyu Park

Принадлежит: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

Provided are a newly identified colon cancer marker and a diagnostic kit using the same. More particularly, the present invention relates to an identified colon cancer specific marker, a composition and a kit including agents determining presence of the marker, and a method of diagnosing colon cancer using the same. The diagnostic marker according to the present invention capable of detecting metastasis and prognosis of colon cancer may provide useful information for the treatment and management of colon cancer and be used for the development of colon cancer-specific anticancer agents.

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Номер записи: 67

06-06-2013 дата публикации

Methods for detection of risk of obesity and risk of onset of diabetes

Номер: US20130143748A1

Автор: Kohjiro Ueki, Matthias Bluher, Sumiko Ozawa, Takashi Kadowaki, Yukiko Okazaki

Принадлежит: Sekisui Medical Co Ltd, University of Tokyo NUC

Provided is a method of measuring the expression level of FSTL3 gene in a biological sample and correlating the measured expression level with the detection of a risk of developing diabetes. Also provided is a method of measuring the expression level of FSTL3 gene in an individual with a BMI value less than 25 not clinically determined as obesity and correlating the measured expression level with the detection of a risk of developing obesity. Further provided is a method of measuring the expression level of FSTL3 gene in an individual with a BMI value less than 25 and correlating the measured expression level with the detection of a risk of developing diabetes. Further provided is a method of measuring an inhibin βB gene expression level and correlating the ratio of expression level of FSTL3 gene to inhibin βB gene with the detection of a risk of developing obesity or diabetes.

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Номер записи: 68

13-06-2013 дата публикации

BARD1 Isoforms in Lung and Colorectal Cancer and Use Thereof

Номер: US20130149711A1

Автор: Irmgard Irminger-Finger, yong-qiang Zhang

Принадлежит: HOPITAUX UNIVERSITAIRES DE GENEVE, UNIVERSITE DE GENEVE

The present invention relates to new BARD1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.

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Номер записи: 69

20-06-2013 дата публикации

Discrete states for use as biomarkers

Номер: US20130157887A1

Автор: Holger Moch, Karsten Henco, Manfred Beleut, Michael Baudis, Peter Schraml, Philip Zimmermann, Wilhelm Gruissem

Принадлежит: Individual

The present invention describes the use of discrete states and signatures for classifying samples.

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Номер записи: 70

11-07-2013 дата публикации

Methods of Detecting Neurological or Neuropsychiatric Diseases or Conditions

Номер: US20130178375A1

Автор: Amin I. Kassis

Принадлежит: Harvard College

This invention provides methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of neurological or neuropsychiatric diseases or conditions. The invention also provides methods of using phagocytic cells alone or in combination with non-phagocytic cells to identify markers of neurological or neuropsychiatric diseases or conditions. Provided are methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of neurological or neuropsychiatric diseases or conditions. Also provided are methods of using phagocytic cells alone or in combination with nonphagocytic cells to identify markers of neurological or neuropsychiatric diseases or conditions.

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Номер записи: 71

11-07-2013 дата публикации

Methods and kits for the diagnosis of prostate cancer

Номер: US20130178393A1

Автор: Andreas Döll, Jaume REVENTÓS PUIGJANER, Juan Morote Robles, Marina RIGAU RESINA, Miguel Abal Posada

Принадлежит: Fundacio Hospital Universitari Vall dHebron Institut de Recerca FIR VHIR

The invention relates to methods and kits for the diagnosis of prostate cancer (PCa) in a subject, for assessing or monitoring the response to a therapy in a subject having PCa or for monitoring the progression of prostate cancer PCa based on the detection of alteration in the expression levels of at least one gene selected from the group of PC A3, PSMA and PSGR. The invention relates as well to methods for assessing whether a subject has to be subjected to a prostate biopsy, said subject having a serum PSA range within 4-10 ng/mL.

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Номер записи: 72

11-07-2013 дата публикации

Long noncoding rna (lncrna) as a biomarker and therapeutic marker in cancer

Номер: US20130178428A1

Автор: Dave S.B. Hoon, Laurent Lessard

Принадлежит: Dave S.B. Hoon, Laurent Lessard

Long noncoding RNAs (lncRNAs) that may be used as cancer biomarkers and methods of diagnosing, prognosing and monitoring cancer including, but not limited to, cutaneous melanoma using said lncRNAs are provided herein. In some embodiments, the methods include steps of isolating one or more lncRNA transcripts in a biological sample from the subject; measuring a test level of the one or more isolated lncRNA transcripts; comparing the test level to a control level of the one or more lncRNA transcripts; and diagnosing or making a prognosis based on the lncRNA level. In some embodiments, the lncRNA transcript is an linc00340 transcript or variant thereof. These lncRNA transcripts may also be used as a therapeutic target in the treatment of cancer.

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Номер записи: 73

18-07-2013 дата публикации

Methods and compositons for cell-proliferation-related disorders

Номер: US20130183281A1

Автор: Lenny Dang, Shengfang Jin, Shin-San Michael Su, Stefan Gross, Valeria Fantin

Принадлежит: Agios Pharmaceuticals Inc

Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).

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Номер записи: 74

18-07-2013 дата публикации

Methods relating to identification of susceptibility to liver injury

Номер: US20130183668A1

Автор: Derek Mann, Jelena Mann, Mujdat Zeybal

Принадлежит: Individual

The present invention relates to methods for identifying susceptibility of impaired hepatic wound healing in a patient, most particularly by identifying modifications of the of PPAR-γ and TGFβ1 genes. It further relates to stratifying populations of patients to determine susceptibility to impaired hepatic wound healing and direct appropriate healthcare resources. More specifically methods can be used to stratify liver disease patient populations to identify those most likely to progress to cirrhosis, or to identify the likelihood that a patient with liver disease will progress to having cirrhosis.

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Номер записи: 75

25-07-2013 дата публикации

Biomarkers for acute ischemic stroke

Номер: US20130189243A1

Автор: Andrew Barry Singleton, Maria Del Mar Matarin, Steven Jay Warach, Taura L. Barr, Yvette P. Conley

Принадлежит: Individual

The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.

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Номер записи: 76

25-07-2013 дата публикации

Rapid phenotypic diagnosis of pathogens and drug resistance using transcriptional expression signatures

Номер: US20130190196A1

Автор: Amy Barczak, Andrew B. Onderdonk, Deborah Hung, James Gomez, Lisa Cosimi, Mark Borowsky, Rob Nicol

Принадлежит: Amy Barczak, Andrew B. Onderdonk, Deborah Hung, James Gomez, Lisa Cosimi, Mark Borowsky, Rob Nicol

The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.

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Номер записи: 77

01-08-2013 дата публикации

Genes Differentially Expressed in Breast Cancer

Номер: US20130196314A1

Автор: Christoph Reinhard, Greg Harrowe, Joerg Kaufmann, Sanmao Kang

Принадлежит: Novartis Vaccines and Diagnostics Inc

A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.

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Номер записи: 78

01-08-2013 дата публикации

Microrna profiling for diagnosis of dysplastic nevi and melanoma

Номер: US20130196869A1

Автор: Anthony Sferruzza, Ke Zhang, Kevin Qu, Renius Owen, Yan Liu

Принадлежит: Quest Diagnostics Investments LLC

Provided herein are methods for miRNA profiling for the diagnosis, prognosis, and management of melanoma and differentiation of melanoma from nevi.

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Номер записи: 79

01-08-2013 дата публикации

Novel biomarkers and targets for ovarian carcinoma

Номер: US20130197056A1

Автор: David G. Huntsman, Kimberly Wiegand, Marco Marra, Martin Hirst, Sohrab Prakash Shah

Принадлежит: British Columbia Cancer Agency BCCA

Novel biomarkers and targets associated with ovarian cancer, particularly clear-cell carcinoma, endometrioid carcinoma, and uterine carcinoma, are disclosed. Mutations in genes encoding proteins that form part of the SWI/SNF chromatin remodelling protein complex, including ARID1A, or loss of expression of such proteins, including BAF250a, can be used to evaluate the likelihood endometriosis will progress or transform to cancer, to provide a prognosis for a patient with cancer, to assess whether conventional treatment is likely to be effective against a cancer, and/or in a synthetic lethal screen to identify novel targets and therapeutics for the treatment of cancer.

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Номер записи: 80

08-08-2013 дата публикации

Materials and methods for diagnosing and predicting the course of prostate cancer

Номер: US20130202717A1

Автор: Harikrishna Nakshatri, Sunil Badve

Принадлежит: Indiana University Research And Technology Corp

Expression of Forkhead-box protein A1 (FOXA1), a transcription factor important for the normal development of the prostate gland is thought to be controlled by steroid hormones and GATA-3. Expression of FOXA1, GATA-3 and androgen receptor (AR) was retrospectively analyzed by immunohistochemistry (IHC) in a series of 80 primary tumors and 28 metastatic prostate cancers including 15 matched paired samples. High nuclear FOXA1 expression was seen in 19% of primary tumors and 89% of metastatic tumors (p<0.0001). FOXA1 expression correlated positively with tumor size, extra-prostatic extension, angiolymphatic invasion, AR and metastasis but did not correlate with age, tumor stage, Gleason score, presence of PIN or multifocality, seminal vesicle or perineural invasion and status of surgical excision margins. Expression of GATA-3 was not seen in either normal epithelium or tumor. High FOXA1 expression is associated with development of metastatic prostate cancer. Accordingly, FOXA1 expression can be used to classify patients at higher risk for metastases.

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Номер записи: 81

08-08-2013 дата публикации

Monitoring immunoglobulin heavy chain evolution in b-cell acute lymphoblastic leukemia

Номер: US20130202718A1

Автор: Francois Pepin, Malek Faham, Mark Klinger, Victoria CARLTON

Принадлежит: Sequenta Inc

The invention is directed to methods of monitoring B-cell lymphoid proliferative disorders, such as B-cell acute lymphoblastic leukemias, by measuring the presence, absence and/or levels of correlating, or index, clonotypes and related clonotypes that have evolved therefrom, for example, as part of the disease condition. In one aspect, such methods are implemented by generating sequencing-based clonotype profiles and determining frequencies of correlating, or index, clonotypes present, including new clonotypes that have evolved therefrom, particularly, in the case of B-cell ALL, by VH substitution. The invention also includes use of such monitoring information to modify treatment status of a patient.

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Номер записи: 82

08-08-2013 дата публикации

Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions

Номер: US20130203624A1

Автор: Amin I. Kassis

Принадлежит: Harvard College

This invention provides methods of using phagocytic cells alone or in combination with non-phagocytic cells in the diagnosis, prognosis, or monitoring of prenatal or pregnancy-related diseases or conditions. The invention also provides methods of using phagocytic cells alone or in combination with non-phagocytic cells to identify markers of prenatal or pregnancy-related diseases or conditions.

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Номер записи: 83

22-08-2013 дата публикации

Hmga2 as a biomarker for diagnosis and prognosis of ovarian cancer

Номер: US20130217015A1

Автор: Patricia A. Kruk, Santo V. Nicosia

Принадлежит: UNIVERSITY OF SOUTH FLORIDA

The subject invention pertains to uses of HMGA2 as a diagnostic biomarker for ovarian cancer and for prediction of a subject's resistance to cancer therapy. The methods of the subject invention are particular useful for early detection of epithelial ovarian cancer.

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Номер записи: 84

05-09-2013 дата публикации

Detection of Micro Metastasis of Melanoma and Breast Cancer in Paraffin-Embedded Tumor Draining Lymph Nodes by Multimarker Quantitative RT-PCR

Номер: US20130231259A1

Автор: Dave S.B. Hoon, Hiroya Takeuchi

Принадлежит: JOHN WAYNE CANCER INSTITUTE

The invention provides a quantitative realtime RT-PCR assay for detection of metastatic breast, gastric, pancreas or colon cancer cells or metastatic melanoma. The assay allows to predict disease recurrence and survival in patients with AJCC stage I and II, and III disease using multimarker panels. The method for detecting metastatic melanoma cells utilizes panels of markers selected from a group consisting of MAGE-A3, GaINAcT, MART-1, PAX3, Mitf, TRP-2, and Tyrosinase. The method for detecting metastatic breast, gastric, pancreas or colon cancer cells in paraffin-embedded samples utilizes panels of markers selected from a group consisting of C-Met, MAGE-A3, Stanniocalcin-1, mammoglobin, HSP27, GaINAcT, CK20, and β-HCG.

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Номер записи: 85

12-09-2013 дата публикации

Lmcd1 cancer markers and methods for their use

Номер: US20130239239A1

Автор: C-Y Chang, Y-S Jou

Принадлежит: Academia Sinica

The present invention provides LMCD1 cancer markers, and methods, compositions, and kits for their use. The invention also provides expression vectors, host cells, and transgenic animals comprising one or more LMCD1 mutations, and methods for their use in characterizing, diagnosing, and treating cancers, and for identifying potential therapeutics. The invention also provides cancer therapeutics.

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Номер записи: 86

19-09-2013 дата публикации

Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence

Номер: US20130244936A1

Автор: Isabelle Fernandez, Philippe Touraine, Sophie Bernichtein, Vincent Goffin

Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM

The present invention relates to an in vitro method of prognosing outcome of hormone-dependent cancer in a subject comprising detecting a constitutively activating mutation in the prolactin receptor (PRLR) gene in a nucleic acid sample previously obtained from said subject, said constitutively activating mutation being preferably a mutation resulting in the expression of a mutant prolactin receptor wherein the isoleucine residue at position 146 is substituted with leucine or a mutation resulting in the expression of a mutant prolactin receptor wherein the isoleucine residue at position 76 is substituted with valine.

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Номер записи: 87

26-09-2013 дата публикации

Method of diagnosing early stage non-small cell lung cancer

Номер: US20130252831A1

Автор: Dung-Tsa Chen

Принадлежит: H Lee Moffitt Cancer Center and Research Institute Inc

A “malignancy-risk” (MR) gene signature score was developed with abundant proliferative genes using principal component analysis. This MR gene signature was shown to be a predictive and prognostic factor of overall survival in early-stage NSCLC. The malignancy-risk signature showed a significant association with OS, with poor survival seen in patients having a higher MR score and better survival seen in patients having a low MR score. As a prognostic factor, the MR gene signature showed a positive correlation with TNM stage, histologic grade, and smoking status. Combination of the MR signature with each clinical parameter often showed the best survival in the low MR group with good clinical outcome. The MR gene profile, tested with a PCA scoring method, discriminated overall survival in lung cancer patients was a predictor independent of pathological staging and other clinical parameters.

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Номер записи: 88

26-09-2013 дата публикации

Genetic variants as markers for use in diagnosis, prognosis and treatment of eosinophilia, asthma, and myocardial infarction

Номер: US20130253847A1

Автор: Daniel Gudbjartsson, Patrick Sulem, Unnur Steina Bjornsdottir

Принадлежит: DECODE GENETICS EHF

Polymorphic variants (e.g., certain alleles of polymorphic markers) that have been found to be associated with high blood eosinophil counts, conditions causative of eosinophilia (e.g., asthma, myocardial infarction), and/or hypertension are provided herein. Such polymorphic markers are useful for diagnostic purposes, such as in methods of determining a susceptility, and for prognostic purposes, including methods of predicting prognosis and methods of assessing an individual for probability of a response to a therapeutic agent, as further described herein. Further applications utilize the polymorphic markers of the invention include, screening methods and genotyping methods. The invention furthermore provides related kits, computer-readable medium, and apparatus.

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Номер записи: 89

03-10-2013 дата публикации

Compositions and methods for detection of mycobacterium avium paratuberculosis

Номер: US20130260374A1

Автор: Angela Burrell, Catherine O'Connell, Craig Cummings, Pius Brzoska, Yongmei JI

Принадлежит: Life Technologies Corp

Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of Mycobacterium avium subsp. paratuberculosis from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.

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Номер записи: 90

03-10-2013 дата публикации

Prostate cancer prognostic compositions and kits

Номер: US20130261171A1

Автор: Alfred J. Witjes, Daphne Hessels, Gerald Verhaegh, Jack A. Schalken

Принадлежит: Radboud University Medical Centre (Radboud UMC)

Described herein are method, compositions and kits for prognosis of prostate cancer. The methods include determining the ratio of PCA3 and of a prostate-specific marker expression in a urine sample and correlating the value of the PCA3/prostate-specific marker ratio with the aggressiveness and mortality risk of prostate cancer in the subject. The method for prognosing prostate cancer in a sample of a patient includes assessing the amount of a prostate cancer specific PCA3 mRNA and the amount of prostate-specific marker in the sample; determining a ratio value of this amount of prostate cancer specific PCA3 mRNA over the amount of prostate-specific marker; comparing the ratio value to at least one predetermined cut-off value, wherein a ratio value above the predetermined cut-off value is indicative of a higher risk of mortality of prostate cancer as compared to a ratio value below the predetermined cut-off value.

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Номер записи: 91

10-10-2013 дата публикации

Single cell analysis by polymerase cycling assembly

Номер: US20130267427A1

Автор: Malek Faham, Thomas Willis

Принадлежит: Sequenta Inc

The invention provides a method of making measurements on individual cells of a population, particularly cells that have identifying nucleic acid sequences, such as lymphoid cells, in one aspect, the invention provides a method of making multiparameter measurements on individual cells of such a population by carrying out a polymerase cycling assembly (PCA) reaction to link their identifying nucleic acid sequences to other cellular nucleic acids of interest. The fusion products of such PCA reaction are then sequenced and tabulated to generate multiparameter data for cells of the population.

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Номер записи: 92

24-10-2013 дата публикации

Prognostic, diagnostic, and cancer therapeutic uses of fanci and fanci modulating agents

Номер: US20130280258A1

Автор: Agata M. Smogorzewska, Alan D. D'andrea, Kay O. Hofmann, Patrizia Vinciguerra, Shuhei Matsuoka, Stephen J. Elledge

Принадлежит: Brigham and Womens Hospital Inc, Miltenyi Biotec GmbH

Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention identifies and characterizes the FANCI polypeptide as a vital component of the Fanconi anemia pathway and discloses inhibitors of FANCI and methods of using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.

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Номер записи: 93

07-11-2013 дата публикации

Marker of breast tumors from the luminal-b subtype

Номер: US20130295571A1

Автор: Christophe Ginestier, Daniel Birnbaum, Fabrice Sircoulomb, Jose Adelaide, Max Chaffanet

Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM

An in vitro method for diagnosing a breast cancer from the luminal-B subtype in a female, includes the steps of analyzing a biological sample from the female by (i) determining the copies number of the ZNF703 gene, and/or (ii) determining the expression of the ZNF703 gene, wherein an increased copies number and/or an over-expression of the ZNF703 gene is indicative of a luminal B tumor; to a kit for diagnosing a breast cancer from the luminal-B subtype in a female including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a method as defined previously, for determining the copies number of the ZNF703 gene, and/or determining the expression of the ZNF703 gene; and to the use of such a kit.

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Номер записи: 94

07-11-2013 дата публикации

Susceptibility of tumors to tyrosine kinase inhibitors and treatment thereof

Номер: US20130296326A1

Автор: Pamela Michelle Pollock

Принадлежит: Translational Genomics Research Institute TGen

This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR2 variants, which are linked to drug resistance. The disclosure further provides methods of diagnosis and theranosis, using these molecules and fragments thereof, and kits for employing these methods and compositions.

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Номер записи: 95

07-11-2013 дата публикации

Medulloblastoma genes as targets for diagnosis and therapeutics

Номер: US20130296408A1

Автор: Bert Vogelstein, Donald Williams Parsons, Gregory J. Riggins, Kenneth Kinzler, MENG Li, Nickolas Papadopoulos, Rebecca J. Leary, Sian Jones, Victor Velculescu, Xiaosong Zhang

Принадлежит: Duke University, JOHNS HOPKINS UNIVERSITY

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis.

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Номер записи: 96

14-11-2013 дата публикации

Gene signatures for cancer diagnosis and prognosis

Номер: US20130302242A1

Автор: Alexander Gutin, Julia Reid, Steven Stone, Susanne Wagner

Принадлежит: Myriad Genetics Inc

Biomarkers and methods using the biomarkers for molecular detection and classification of disease and, particularly, molecular markers for cancer diagnosis and prognosis and methods of use thereof are provided.

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Номер записи: 97

14-11-2013 дата публикации

Use of modulators of CCR5 in the treatment of Cancer and cancer metastasis

Номер: US20130303512A1

Автор: Richard G. Pestell

Принадлежит: Individual

This disclosure is directed, in part, to a method of determining whether a subject having cancer is at risk for developing metastasis of the cancer. In one embodiment, the method comprises (a) obtaining a biological sample from the subject having cancer; (b) determining CCR5 expression level and/or expression level of at least one of CCR5 ligands in the biological sample; and (c) if the expression level of CCR5 and/or of at least one of CCR5 ligands determined in step (b) is increased compared to CCR5 expression level and/or expression level of at least one of CCR5 ligands in a control sample, then the subject is identified as likely at risk for developing metastasis of the cancer.

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Номер записи: 98

14-11-2013 дата публикации

CB2 Receptor Modulators in Neurodegenerative Diseases and Applications of the Same

Номер: US20130303528A1

Автор: John P. Crow, Paul L. Prather

Принадлежит: University of Arkansas

Compositions for the treatment of neurodegenerative diseases are disclosed. Methods of treating and monitoring progression of a neurodegenerative disease are disclosed. According to the present invention, a selective CB2 receptor modulator may be administered to a mammal for the treatment of a neurodegenerative disease.

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Номер записи: 99

14-11-2013 дата публикации

Genetic polymorphisms associated with stroke, methods of detection and uses thereof

Номер: US20130303558A1

Автор: James J. Devlin, May Luke

Принадлежит: Celera Corp

The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

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Номер записи: 100