Histone Deacetylase Inhibitors

This invention relates to iminodiacetic acid and diamine hydroxamic acid derivatives, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.

METHOD AND APPARATUS FOR ADJUSTING THE PRESSURE SENSOR MEASUREMENT RANGE IN A TIRE PRESSURE MONITORING SYSTEM

A tire pressure monitoring system (12) for a vehicle (10) has a pressure sensor circuit (16A) that includes an ECU (95), a transmitter/receiver (90), and pressure sensor (94). A method of operating a tire pressure monitoring system includes calibrating a tire pressure sensor circuit in a first range and a second range and generating a first calibration data for the first range and second calibration data for the second range. The first calibration data and the second calibration data are stored in a memory of the tire pressure sensing circuit (16A). A data signal corresponding to the pressure is generated. The first or second calibration data is generated in response to the range of the data signal to form a selected calibration. The data signal is calibrated with the selected calibration to form a pressure indicative signal. The pressure indicative signal is transmitted to a receiver (28) within the vehicle (10) with a range status corresponding to the selected calibration. A pressure ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1. A method for transmitting data between devices of an analyte monitoring system , the method comprising:generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor;establishing a two-way communication channel between the sensor electronics module and the a display device and each of the sensor electronics module and display device transmitting at a first transmission power; andinitiating a low power transmission mode responsive to sensing user input at user interface of the display device indicative of entering the mode, wherein the low power transmission mode comprises one or both of the sensor electronics module and the display device transmitting at a second transmission power that is lower than the first transmission power.2. The method of claim 1 , wherein the initiating comprises the display device sending a command to the sensor electronics module to enter the low power mode.3. The method of claim 1 , wherein the display device prompts a user to input a duration of time for the low power transmission mode claim 1 , and wherein the display device and the sensor electronics module automatically exit the low power transmission mode after expiration of the duration of time.4. The method of claim 1 , further ...

DEVICE FOR DETERMINING MATERIAL PROPERTIES

A device for determining material properties includes a bottom panel extending from a first end to a second end of the device, for supporting a material to be tested. A closed loop flexible wall extends upwardly from the panel and is in operational engagement with a flexible wall idle means towards the first end of the device and a flexible wall driving means in spaced relation with the flexible wall idle means. The flexible wall driving means causes movement of the closed loop flexible wall along a predetermined closed loop path. The flexible wall driving means and the means of driving it are arranged at a position outside of a material containment area of the device. 1. A device for determining material properties , the device including:a first end;a second end;a bottom panel, extending from the first end to the second end, for supporting a material to be tested;a closed loop flexible wall arranged to extend upwardly from the bottom panel;a flexible wall idle means disposed towards the first end of the device;a flexible wall driving means disposed in spaced relation with the flexible wall idle means;the closed loop flexible wall being arranged in operational engagement with the flexible wall idle means and the flexible wall driving means so that movement of the flexible wall driving means causes movement of the closed loop flexible wall along a pre-determined closed loop path;means to drive the flexible wall driving means; andmeans for measuring one or more properties of the material to be tested;wherein the bottom panel and the closed loop flexible wall together form a material containment area therewithin, and wherein the flexible wall idle means, the flexible wall driving means and the means for driving the flexible wall driving means are each arranged at a position outside of the material containment area.2. The device of claim 1 , wherein the flexible wall driving means is any one of a driving wheel claim 1 , pulley claim 1 , gear or cog arranged in ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 120-. (canceled)21. A method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information , the method comprising:activating a transceiver of a first communication device associated with an analyte sensor at a first time;establishing a two-way communication channel with the second communication device; andwherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup transmitted from the second communication device using a short-range communication.22. The method of claim 21 , wherein the establishing the two-way communication channel includes using authentication information related to the transceiver claim 21 , wherein the authentication information comprises a transmitter serial number.23. The method of claim 22 , wherein the first communication device comprises a tag associated with the short-range communication powered by the second communication device.24. The method of claim 23 , wherein the second communication device is configured to engage in the short-range communication with the first communication device claim 23 , and wherein the second communication device comprises an initiator ...

SYSTEMS AND METHODS FOR RESERVOIR FILLING

Systems and methods allow for limiting a presence of air bubbles in a fluidic medium filled into a reservoir. A fluidic medium may be forced from a vial into a reservoir. A vial may be degassed prior to being used to fill a reservoir. A filling process may be automated and a membrane may be located in a fluid flow path to trap air bubbles in a fluidic medium being filled into a reservoir.

COAXIAL CABLE CONNECTOR WITH GROUNDING MEMBER

A coaxial cable connector includes tubular post, a coupler secured over an end of the tubular post for securing the connector to an appliance, and an outer body secured to the tubular post. An electrical grounding path is maintained between the coupler and the tubular post whether or not the coupler is tightly fastened to the appliance. The electrical grounding path is provided by a resilient, electrically-conductive grounding member disposed between the tubular post and the coupler. Alternatively, the connector includes conductive grease at a point where mating portions of the tubular post and coupler have closely matching dimensions.

Laminate facing for fiber reinforced materials and composite materials formed therefrom

The present invention provides a laminate material having a polyester film and a layer of polyester fibers cohesively bonded thereto. Generally, a metal layer deposited at least one surface of the laminate. The invention may also include a glass reinforced polymer layer formed on the laminated facer where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. The laminate may further include a second polymer layer having a thickness joined to the fiber layer and/or a layer of hot melt adhesive applied to the polyester fibers. Also presented is a composite material having a polyester film, a layer of polyester fibers bonded to the second polymer layer; a second polymer layer joined to the polyester film; and a glass reinforced polymer layer formed on the laminated facer, where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer.

FILTER ARRANGEMENTS; HOUSING; ASSEMBLIES; AND, METHODS

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is permanently mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a radial seal thereon. 1. A safety filter element for use in an air cleaner assembly; the safety element comprising:(a) an outer skirt having two opposite curved ends, and two, opposite, sides;(b) pleated media positioned surrounded by the skirt;(c) a radial seal positioned on the skirt; and(d) a projection extending outwardly from a first one of the curved ends, in a direction opposite a second one of the curved ends, by a distance of at least 5 mm.2. A safety filter element according to including:(a) a handle spaced from the projection.3. A safety filter element according to wherein:(a) the handle includes an opening therethrough.4. A safety filter element according to wherein:(a) the projection extends in the direction opposite the second one of the curved ends by a distance of at least 10 mm.5. A safety filter according to wherein:(a) the projection has a width, in a direction corresponding to a direction between the opposite sides of the outer skirt, of at least 10 mm.6. A safety filter according to wherein:(a) the projection has a width, in a direction corresponding to a direction between the opposite sides of the outer skirt, of at least 20 mm.7. A safety filter according to wherein:(a) the projection has a width, in a direction corresponding to a direction between the opposite sides of the outer skirt of 25-80 mm.8. A safety filter according to wherein:(a) the projection includes ribs.9. A safety filter according to wherein:(a) the pleats of the pleated media extend in a direction between the curved ends of the outer skirt.10. A safety filter according to wherein:(a) the pleats of the pleated media extend in a direction between the curved ends of the outer skirt.11. A safety filter element according to wherein:(a) the projection extends in a ...

Composite Materials with Multilayer Laminate Facing

A composite board with a multilayer laminated facer is presented having a nonwoven, a first polymer layer, and a second polymer layer. The laminate may be printed on the nonwoven, on the upper surface of the first polymer layer or inverted printed on the backside of an applied film. A number of configurations for the polymer layers are disclosed. The laminate may include exposed fibers on the lower surface or the nonwoven may be saturated. A removable peel-ply may be included. By controlling the placement and thickness of the polymer layers it is possible to tailor additive in the polymers such as colorants, opacifiers, UV stabilizers, and fire retardants to improve quality and reduce costs. In an alternate embodiment of the present invention, a first polymer layer is applied to the topside of the nonwoven and the second polymer is laminated to the first polymer layer as a preformed film. The laminated facer is thermally or adhesively bonded to the composite board. 1. A composite material with a multilayer laminated facer , comprising: a polymer matrix;', 'a plurality of reinforcing fibers dispersed within the matrix; and, 'a fiber reinforced polymer board; including'} a nonwoven having an upper surface and a lower surface;', 'a first polymer layer having an upper surface and a lower surface; and', 'a second polymer layer having an upper surface and a lower surface., 'a laminated facer on the fiber reinforced board, including2. The composite material of claim 1 , wherein the first polymer layer is applied to the lower surface of the nonwoven and the second polymer layer is applied to the upper surface of the nonwoven.3. The composite material of claim 1 , further comprising:a printed layer on the upper surface of the non-woven.4. The composite material of claim 1 , wherein thea printed layer is at the interface between the first and second polymer layer.5. The composite material of claim 1 , wherein the upper surface of the non-woven and the upper surface of the ...

AIR CLEANER ARRANGEMENTS; COMPONENTS; AND METHODS

An air cleaner assembly and components therefor are described. The components include features of an air cleaner housing; advantageous main filter cartridges; and, advantageous safety filter cartridge features. Features of the main filter cartridge are provided to engage an access cover of the assembly, and a cartridge support within the housing, in a preferred manner. Methods of assembly and use are also described. 1. A main filter cartridge for use in an air cleaner assembly having a central cartridge support including an end with a central projection and an outer ring projection spaced from the central projection by a receiving groove; the main filter cartridge comprising: '(i) the media pack comprising media configured in a conical shape;', '(a) a media pack surrounding an open filter interior and having first and second ends;'} (i) the first end cap having a central aperture therethrough; and,', '(ii) the first end cap including a radially directed seal member thereon, molded integral with a remainder of the end cap; and,, '(b) a first end cap positioned on the media pack first end with the media embedded therein;'} (i) the outer surface including a receiving groove having inner and outer walls; the outer wall being spaced at least 15 mm from the media;', '(ii) the receiving groove on the outer surface of the second end cap being defined by a ring projection on the inner surface of the second end cap that is sized and located to project into the receiving groove on a central cartridge support; and,', '(iii) the outer surface having a projection thereon surrounded by the receiving groove and defining a central receiver on the inner surface sized to locate the central projection on a central cartridge support projecting therein., '(c) a second end cap positioned opposite the first end cap; the second end cap being closed and having an inner surface and an outer surface;'}2. A main filter cartridge according to wherein:(a) the central projection has a circular ...

BASEBALL AND SOFTBALL HITTING TRAINING DEVICE

The present invention is a baseball and softball hitting training device that prevents early arm extension, early wrist release, swinging the bat from the outside to the inside, throwing the back shoulder toward the plate, or otherwise casting the hands during a swing. The device comprises a support block with one or more grooves, a horizontal bar mounted perpendicular to the support block, a flag indicator connected perpendicular to the horizontal bar, and one or more attachment straps.

An improved steam engine having an automatic valve motion andan automatic changeable expansion

Cooking Appliance Including Combination Heating System

A combination cooking appliance controls a radiant heating element provided in an oven cavity, both a blower and a convection heating element provided in an air plenum, and microwave energy sources to provide for numerous potential operating modes. The present invention is particularly concerned with the manner in which the various cooking components are configured and flexibly controlled to provide for short cook cycles in a variety of operational modes.

Virtual logging system and method

A common transactional logging system (a “virtual logging system”) that presents to one or more log clients the appearance that each log client is interacting with a dedicated logging system. In reality, the virtual logging system is multiplexing multiple virtual log streams, including log records, for each log client into a single transactional log.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises activating a transceiver of a first communication device associated with an analyte sensor at a first time. The method also includes establishing a two-way communication channel with the second communication device. The activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

ACOUSTIC RECEIVER AND METHOD OF MAKING SAME

An acoustic receiver includes a first receiver subassembly having bottom housing plate with at least a portion of a motor fastened thereto, and a second receiver subassembly having a closed-ended housing wall with at least one open end that is fastened to the bottom housing plate. A method of making and assembling the components is also described. 1. An acoustic receiver comprising: a bottom housing plate; and', 'a motor disposed on the bottom housing plate, the motor including a coil having a passage, a yoke retaining first and second magnets, and a reed having a portion extending through the passage and between the magnets;, 'a first receiver subassembly comprisinga second receiver subassembly comprising a closed-ended housing sidewall having a first open end, the first receiver subassembly and the second receiver subassembly are separate components,the bottom housing plate disposed over and fastened to the first open end of the closed-ended housing sidewall to form at least a portion of a receiver housing, wherein the closed-ended housing sidewall is disposed about the motor;a diaphragm located in the receiver housing, the diaphragm separating an interior of the receiver housing into a front volume and a back volume, wherein the motor is disposed in the back volume;a link interconnecting a movable portion of the reed with a movable portion of the diaphragm,wherein the reed is movable between the first and second magnets in response to an excitation signal applied to the coil.2. The receiver of claim 1 , wherein the closed-ended housing sidewall includes an acoustical port through a portion of the sidewall forming the front volume and a lead pass-through opening through a portion of the sidewall forming the back volume.3. The receiver of claim 2 , wherein the closed-ended housing sidewall is a folded sheet material having a first end and a second end coupled at a butt joint claim 2 , wherein the folded sheet material has multiple sidewall portions.4. The receiver ...

Modified malonate derivatives

The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions ...

Filter arrangements; housing; assemblies; and, methods

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is permanently mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a radial seal thereon.

Histone Deacetylase Inhibitors

This invention relates to hydroxamic acid derivatives having a urea linkage, that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous system (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.

EXPANDABLE CONTAINMENT PLOW

Provided is a material handling assembly, such as a plow, that may contain additional features mounted thereon so as to increase the functionality of the assembly, and an apparatus and method for mounting such an assembly or other like structure onto a vehicle, such as a truck. A plow mounting apparatus may be used for automatically mounting and dismounting a plow blade to an end of an associated vehicle. The plow mounting apparatus includes a plow assembly comprising: an expandable plow blade pivotally attached to a front portion of a plow frame; a lift frame attached to a rear portion of the plow frame; an auxiliary light mounting apparatus attached to the plow frame; and a height adjustment mechanism that is operable to raise and lower the plow blade assembly relative to the ground. The height adjustment mechanism may include a hydraulic cylinder having a top portion and a bottom portion. The vertical pull structure is attached to the lift frame and includes an outer vertical sleeve and an inner vertical member which is slidingly engageable with the outer vertical sleeve. The light mounting apparatus includes a cross member affixed to a lift frame of a plow assembly and first and second horns which are positioned within the interior of the first and second ends of the cross member such that they are adjustable by way of a fastener.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1a transcutaneous glucose sensor comprising an in vivo portion, wherein the transcutaneous sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, wherein the at least one electrode is a working electrode;a sensor electronics unit operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics unit comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor; anda display device operatively connected to the sensor electronics unit, wherein the display device is configured to display a glucose value.. A transcutaneous glucose sensor system, the system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/925,233, filed Jul. 9, 2020, which is a continuation of U.S. application Ser. No. 16/546,099, filed Aug. 20, 2019, which is a continuation of U.S. application Ser. No. 15/413,206, filed Jan. 23, 2017, now abandoned, which is a continuation of U.S. application Ser. No. 13/830,330, filed Mar. 14, 2013, now U.S. Pat. No. 9,788,354, which is a ...

Medical device

A medical device for example a wound dressing having antibacterial and optionally, antifungal properties, are provided together with methods for making the device. An exemplary dressing includes a layer of silver-containing fabric, (optionally) a layer of absorbent material, and (optionally) a layer of flexible air-permeable and/or water-impermeable material. The dressing can be used for prophylactic and therapeutic care and treatment of skin infections and surface wounds (including surgical incisions), as a packing material, and as a swab for surface cleaning.

Trajectory guide with instrument immobilizer

A method and apparatus accurately maintains alignment of a surgical instrument. The apparatus includes a base with an attached movable member. The movable member includes a passage forming a portion of a trajectory path. A relaxable or rigid material has a similar passage in common with the passage of the movable member. If a relaxable material is used, the passage portion of the relaxable region is held open by an inserted stem removably attached to the movable member. The instrument is then inserted into the center of the stem and thus into the trajectory path. The stem is removed by withdrawing it from the movable member over the proximal portion of the instrument. This releases the relaxable region to tightly hold the instrument in place. Alternatively, using a relaxable or rigid component, the component is slid laterally to at least partially offset a passage through the component from the passage of the movable member to reduce a combined effective area of the passages and to grasp ...

Injection device

An injection device comprising an incremental clicking mechanism providing the user with an indication of the number of doses being set. For handling different types of medicaments having different dose volumes in the same type of injection device it is beneficial to provide an additional clicking means which is easy changeable. In this way different dose volumes can be dispensed by the same type of injection devices simply by utilizing different clicking means. The clicking means is preferably a curved track provided between the dose setting member and a non-rotatable clicker element.

Portable fluorescent drop-light

A hand-held fluorescent lamp assembly powered by typical line supply of 120 VAC, 60 Hz via an attached power cord and employing multiple commonly available fluorescent lamps. The assembly includes switches to independently control the multiple fluorescent lamps. The assembly includes lightweight solid state power regulation components. The power regulation circuit employs a self-oscillating circuit that is approximately matched in frequency of oscillation to the natural frequency of the fluorescent lamp load to automatically ignite the fluorescent lamps. The power regulation circuit includes circuit elements to automatically protect the ballast circuit and lamps from overdrawing in the run state and from abnormal load conditions.

Printed wiring board structure with z-axis interconnections

A structure of and method for producing a multilayer printed or wiring circuit board, and more particularly a method producing so-called z-axis or multilayer electrical interconnections in a hierarchial wiring structure in order to be able to provide for an increase in the number of inputs and outputs (I/O) in comparison with a standard printed wiring board (PWB) arrangement, and a printed wiring board produced by the method.

Robust method and system for the automatic detection of a detached remote tire pressure sensor of a tire pressure monitoring system

A tire pressure monitoring system for detachment detection of a tire pressure sensor is provided. The system includes a tire pressure sensor, a receiver and a controller. The tire pressure sensor includes a transmitter for transmitting a word having a detachment state. The receiver is for receiving the word and is coupled to the controller. The controller decodes the word and determines the detachment state of the tire pressure sensor. A robust method for the automatic detection of a detached tire pressure sensor of a tire pressure monitoring system is also provided.

Nuclear matrix protein fluid assay

Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.

Spirocyclic Compounds

The present invention relates to a novel class of substituted spirocyclic compounds, represented by the following structural Formula: I Wherein A, B and D are independently selected from CR12, NR1a, C(O) and O; E is selected from a bond, CR12, NR1a, C(O) and O; wherein at least one of A, B, D or E is CR12; and provided that when A is O, then E is not O; G is CR12; R is selected from NH2 and OH; These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing termin differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central ...

Systems and methods for processing and transmitting sensor data

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Audio device with acoustic valve

A hearing device such as a hearing aid, ear pod, headphone, or other wearable is provided, whose components include the following: an acoustic transducer with a vent port operable to produce sound, a housing of the acoustic transducer with a sound opening, and an actuatable acoustic valve disposed in the housing, where the acoustic valve is actuatable to alter passage of sound through the acoustic vent to change the state of the hearing device between an open vent state and a closed vent state, so that actuation of the valve changes an acoustic characteristic of the hearing device.

AIR FILTER ARRANGEMENT; ASSEMBLY; AND, METHODS

Air filter cartridges are disclosed. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described. 1. An air filter cartridge comprising: (i) the filter media pack including filter media defining a plurality of parallel ridges extending in a direction parallel to a central flow axis between the first flow face and the second flow face;', '(ii) the filter media pack being closed to passage of air therethrough, from the first flow face to the second flow face, without filtering passage through the filter media;', '(iii) the filter media pack having a rectangular cross-sectional shape in a direction perpendicular to the central flow axis; and', '(iv) the filter media pack comprising four sides, including a first pair of first and second opposite sides and a second pair of first and second opposite sides, extending between the first flow face and the second flow face;, '(a) a filter media pack having a first flow face and a second, opposite, flow face;'}(b) first and second side pieces positioned, respectively, on the first pair of first and second opposite sides of the filter media pack; and (i) the seal member including a seal surface extending around the four sides of the filter media pack and generally facing toward one of the first flow face and the second flow face, and positioned for sealing engagement with a housing component in use;', '(ii) the seal surface being positioned spaced from the second flow face in a direction toward the first flow face;', '(iii) the seal surface extending across the first side piece and the second side piece along a path at an angle X of at least 2 degrees to a plane perpendicular to the central flow axis; and', '(iii) the seal surface being spaced from the filter media by a receiving trough extending at least partially around the filter media pack., '(c) a housing seal arrangement, including a seal member, extending around the four sides of the ...

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Nuclear matrix protein fluid assay

Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.

AUDIO DEVICE WITH VALVE STATE MANAGEMENT

Methods and apparatus determine the actual state of one or more acoustic valves e.g., whether an acoustic valve is open or closed, in a hearing device. A sensor in the hearing device is configured to generate an output signal indicative of a state of the acoustic valve. An electrical circuit actuates the acoustic valve if the actual state is different than a desired state. The determination of the state of the acoustic valve can be done on the hearing device or on a remote device. 1. A hearing device comprising:a housing having a contact portion configured to form a substantially sealed coupling with a user's ear, the housing having a sound opening;an electro-acoustic transducer disposed in the housing, the transducer configured to generate an acoustic signal in response to an electrical excitation signal applied thereto, wherein an acoustic signal generated by the transducer emanates into the user's ear via the sound opening when the portion of the housing is coupled to the user's ear;an acoustic valve disposed in an acoustic passage of the housing, the acoustic valve actuatable to alter passage of sound through the acoustic passage;a sensor configured to generate an output signal indicative of a state of the acoustic valve;an electrical circuit configured to actuate the acoustic valve based on the output signal of the sensor.2. The device of claim 1 , the acoustic valve includes an electrical valve coil claim 1 , the sensor is a circuit configured to sense impedance of the valve coil in response to a diagnostic signal applied to the valve coil claim 1 , wherein the impedance of the valve coil is indicative of the state of the acoustic valve.3. The device of claim 2 , the electrical circuit is configured to apply an AC diagnostic pulse to the valve coil without actuation of the valve.4. The device of claim 1 , the sensor is a microphone having an output coupled to the electrical circuit.5. The device of claim 1 , wherein the sensor includesa first microphone ...

Nuclear matrix protein fluid assay

Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.

Compound toggle link retention mechanism

A quick release and toggle locking mechanism for a conventional pliers-type, toggle-locking hand tool comprises a compound toggle link. The mechanism includes a compound link pivotally connected to a movable handle and a toggle link. Retention means is provided for restricting pivotal movement of the compound link relative to the movable handle.

Vehicle warning system and method

A vehicle warning system and method. A detector is onboard a first vehicle and automatically detects a travel condition problem encountered by the first vehicle at a first location. A vehicle position locator automatically determines the first location of the first vehicle. A communicator automatically transmits the determined first location and the detected travel condition problem to a second location. In one example, the vehicle is an automotive vehicle, and the second location is a communications center which transmits the determined first location and the detected travel condition problem (such as an icy roadway or a traffic jam) to only those other vehicles headed toward the first location.

Air filter arrangement; assembly; and, methods

An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and defining a media pack having opposite flow faces. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described.

Coil with different windings

Two coils are wrapped in one of numerous different implementations. In one implementation, the two coils are wrapped about a portion of a bobbin that has at least three flanges. The first coil is disposed about a first portion of the bobbin between the first flange and the second flange, and a second coil is disposed about a second portion of the bobbin between the second flange and the third flange.

Multi-lumen instrument guide

This document discusses, among other things, a method of manufacture including a mold having at least one pin, and surrounding the pin with a hardenable material to form a first guide layer. The mold and pin are removed from the resulting first guide layer, to define a substantially untapered first instrument passage that corresponds to the geometry of the pin. Optionally, the first instrument passage includes at least five substantially untapered channels including a central channel. The first instrument passage is aligned with a substantially untapered second instrument passage of a stacked second guide layer. In a further example, the first and second guide layers are coupled to a guide coupler that cooperatively aligns the first and second instrument passages. The guide layers can be used with a trajectory guide for image guided surgery.

DEVICE FOR IMMOBILIZING A PRIMARY INSTRUMENT AND METHOD THEREFOR

Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

Injection Device with a Processor for Collecting Ejection Information

A medication delivery device comprises an injection device having a reservoir comprising a medicament to be ejected, and a sensor arranged to detect an ejection of the medicament from the injection device, the sensor being arranged to output a signal comprising ejecting information, and a processor for collecting and storing the ejection information.

ADAPTING SHORT-WAVELENGTH LED'S FOR POLYCHROMATIC, BROADBAND, OR "WHITE" EMISSION

An adapted LED is provided comprising a short-wavelength LED and a re-emitting semiconductor construction, wherein the re-emitting semiconductor construction comprises at least one potential well not located within a pn junction. The potential well(s) are typically quantum well(s). The adapted LED may be a white or near-white light LED. The re-emitting semiconductor construction may additionally comprise absorbing layers surrounding or closely or immediately adjacent to the potential well(s). In addition, graphic display devices and illumination devices comprising the adapted LED according to the present invention are provided.

System and Method for Manufacturing a Transducer Module

A receiver includes a housing having an interior, a diaphragm assembly disposed within the housing, a motor assembly disposed within the housing and a linkage assembly coupling the diaphragm assembly and the motor assembly. A support structure joined to the diaphragm or the motor assembly or to both the diaphragm and the motor assembly. The support structure includes a cooperative surface portion engaging the housing to position and retain the joined diaphragm assembly or motor assembly within the interior. A corresponding method of manufacture employs a support structure for positioning components of the receiver in the housing. A receiver may also incorporate a microphone to through pass acoustic signals external to the receiver housing through the receiver. An earphone assembly may incorporate a receiver as described.

Benzothiophene hydroxamic acid derivatives

The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which ...

Systems and methods for processing and transmitting sensor data

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Transactional file system

A transactional file system wherein multiple file system operations may be performed as part of a user-level transaction. An application specifies that the operations on a file, or the file system operations of a thread, should be handled as part of a transaction, and the application is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a component within the file system manages the operations consistent with transactional behavior. The component, which may be a resource manager for distributed transactions, provides data isolation by providing multiple versions of a file by tracking copies of pages that have changed, such that transactional readers do not receive changes to a file made by transactional writers, until the transactional writer commits the transaction and the reader reopens the file. The component also handles namespace logging operations in a multiple-level log that facilitates logging and recovery.

PERSONAL LISTENING DEVICE

A receiver module for a personal listening device to be fitted in the ear, on the ear, near the ear, or behind the ear, the receiver module having a movable armature, the receiver module comprises a motor assembly and a housing defining a chamber, the housing is made from a material that is corrosion resistant and is biocompatible to human skin contact. The receiver module further comprises at least one motor assembly directly disposed in the chamber. Optionally a communication link adapted to couple or decouple with the motor assembly. At least a portion of the communication link is disposed in the housing.

Medical device introducer

An introducer is described that is coupled to a patient, specifically a patient's skull. The introducer may include an advancer that is remote from the patient, the advancer communicating with the introducer by means of a cable system. The introducer may also include a local position sensor that indicates the position of the primary medical device being introduced. The introducer may also include a frameless reference system that locates the primary medical device relative to a table that the patient is fixed to.

Modified Malonate Derivatives

The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the modified malonate derivatives and safe dosing regimens of these pharmaceutical compositions ...

Floor console with reconfigurable storage

A storage system for a vehicle passenger compartment provides reconfigurable storage for cds, trash and other items. The storage system includes multiple portable storage containers that are selectively mountable at several optional locations in the vehicle passenger compartment, or storable inside a floor console. One of the example portable storage containers is a cd sleeve and the other example portable storage container is a receptacle, such as for trash storage. In the example embodiments, the portable storage containers are securable to one of a plurality of interior panels via a magnetic coupling between the portable storage container and the interior panels. Additional mechanical coupling may be provided to prevent the storage containers from slipping on the interior panels. For example, in the portable trash storage receptacle, a protrusion is received in a complementary recess between the container wall and the interior panel, in order to prevent the container from sliding. The ...

Thermally stabilized sensors for cooled electrical packages

Described is a thermally stabilized sensor for cooled component packages. A cooled component package includes a cooled component, a temperature-sensing device located adjacent to the cooled component, and a heat flow modifier located adjacent to the temperature-sensing device. Examples of the heat flow modifier include a ground shield, a wire bonded to platform upon which the cooled component is mounted, and a bonding layer between a refrigerator element and an optical subassembly that includes the cooled component.

Thiophene and Benzothiophene Hydroxamic Acid Derivatives

The present invention relates to a novel class of hydroxamic acid derivatives having a benzothiophene or thiophene backbone. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit historic deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Method and apparatus for fabricating optical fiber using improved oxygen stoichiometry and deuterium exposure

Embodiments of the invention include a method for making optical fiber having reduced aging or hydrogen aging loss over the life of the fiber and optical fiber systems including such optical fibers. Improved silicon-oxygen stoichiometry during one or more preform manufacturing steps reduces the amount of Si defects generated in the optical fiber preform. Also, deuterium exposure of optical fiber drawn from the preform reduces the likelihood of having atomic defects such as Si defects in the optical fiber that, over time, attract and bond with hydrogen atoms to form molecules that contribute to increased water absorption loss. The inventive method produces optical fibers with improved transmission characteristics, e.g., optical fibers made by methods according to embodiments of the invention have transmission loss at 1385 nanometers that is less than 0.33 dB/km and the aging loss increase thereafter is less than 0.04 dB/km.

Expandable Containment Plow

Provided is a material handling assembly, such as a plow, that may contain additional features mounted thereon so as to increase the functionality of the assembly, and an apparatus and method for mounting such an assembly or other like structure onto a vehicle, such as a truck. A plow mounting apparatus may be used for automatically mounting and dismounting a plow blade to an end of an associated vehicle. The plow mounting apparatus includes a plow assembly comprising: an expandable plow blade pivotally attached to a front portion of a plow frame; a lift frame attached to a rear portion of the plow frame; an auxiliary light mounting apparatus attached to the plow frame; and a height adjustment mechanism that is operable to raise and lower the plow blade assembly relative to the ground. The height adjustment mechanism may include a hydraulic cylinder having a top portion and a bottom portion. The vertical pull structure is attached to the lift frame and includes an outer vertical sleeve and an inner vertical member which is slidingly engageable with the outer vertical sleeve. The light mounting apparatus includes a cross member affixed to a lift frame of a plow assembly and first and second horns which are positioned within the interior of the first and second ends of the cross member such that they are adjustable by way of a fastener. 1. A material handling box assembly to be mounted on a vehicle , such as a truck , comprising:a main blade consisting of a plate having a concave front surface opposite a convex rear surface; being elongated along its width to define a pair of lateral ends opposed to one another, the elongation defining an axis of elongation; and a plurality of substantially vertical, laterally spaced apart gussets engaged to the rear surface but absent from the lateral ends of the main blade;a guide frame engaged directly to the rear surface to provide structural support thereto, elongated in the width direction, extending the width of the blade; ...

Benzothiophene hydroxamic acid derivatives

The present invention relates to a novel class of hydroxamic acid derivatives. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the hydroxamic acid derivatives and safe dosing regimens of these pharmaceutical compositions, which ...

Magazine assembly for fastening tool

A magazine assembly for a fastening tool. The magazine assembly slides on guide posts that are formed into the nose assembly of the fastening tool and is clamped to the fastening tool via a magazine clamp assembly that requires no tools to operate. The magazine clamp assembly may be partially released to permit the magazine assembly to be partially withdrawn from the nose assembly so that the nose assembly may be maintained without the complete removal of the magazine assembly. The construction of the nose assembly is such that when the magazine assembly is placed in a partially withdrawn state, a portion of the nose assembly mechanically inhibits actuation of the fastening tool trigger system.

COIL WITH DIFFERENT WINDINGS

Two coils are wrapped in one of numerous different implementations. In one implementation, the two coils are wrapped about a portion of a bobbin that has at least three flanges. The first coil is disposed about a first portion of the bobbin between the first flange and the second flange, and a second coil is disposed about a second portion of the bobbin between the second flange and the third flange. 1. A bobbin comprising:at least a first flange, a second flange, and a third flange;a first coil disposed about a first portion of the bobbin between the first flange and the second flange; anda second coil disposed about a second portion of the bobbin between the second flange and the third flange.2. The bobbin of claim 1 , further comprising a reactive circuit element coupled with the first coil or the second coil.3. The bobbin of claim 2 , wherein the reactive circuit element is coupled in series with the first coil or the second coil.4. The bobbin of claim 2 , wherein the reactive circuit element is coupled in parallel with the first coil or the second coil.5. The bobbin of claim 2 , wherein the reactive circuit element includes a capacitor.6. The bobbin of claim 1 , further comprising a plurality of electrical terminals embedded in the bobbin claim 1 , each electrical terminal electrically coupled to a corresponding at least one end of the first coil or the second coil.7. The bobbin of claim 1 , wherein the first coil has a different turn from the second coil.8. The bobbin of claim 1 , wherein the reactive circuit element is mounted directly on the bobbin.9. An acoustic receiver comprising:a housing;a diaphragm disposed in the housing and at least partially defining a front volume and a back volume, the front volume acoustically coupled to an acoustic output of the receiver;an armature linked to the diaphragm; anda bobbin disposed about a portion of the armature, the bobbin comprising:at least a first flange, a second flange, and a third flange;a first coil ...

Acoustic receivers with multiple diaphragms

Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.

Rod-in-tube optical fiber preform and method

An optical fiber preform includes a core rod and an overclad tube having an open, distal end dimensioned to enter the mouth of a vertical fiber draw furnace. A plug is fixed in the region of the distal end of the tube, and the core rod is disposed axially inside the overclad tube so that a distal end of the rod is restrained from downward movement by the plug as the tube enters and descends into a hot zone of the draw furnace. The distal end of the tube is heated in the furnace hot zone until the tube and the plug soften and fuse with one another. The tube then collapses onto the core rod to produce a drop from which an optical fiber having desired properties may be drawn.

Injection device with a dose setting limiter

An end-of-content arrangement for preventing a dose setting member of an injection device to be set to a dose larger that the medicament remaining in the injection device. The arrangement is particular suitable for injection devices operating with non-equistant dose volumes. The arrangement comprises an indentation provided on the housing or on the dose setting and injection member which indentation arrest a stop member when less than one dose unit is left in the cartridge. The stop member is coupled to the dose setting member such that the interaction between the indentation and the stop member prevents a dose larger that the remaining medication in being set.

Methods for identifying, diagnosing, and predicting survival of lymphomas

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

ACOUSTIC RECEIVERS WITH MULTIPLE DIAPHRAGMS

Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm. 1. A balanced armature receiver comprising:a housing having a first internal volume and a second internal volume;a first diaphragm separating the first internal volume into a first front volume and a first back volume, the first front volume having a first sound outlet port;a second diaphragm separating the second internal volume into a second front volume and a second back volume, the second front volume having a second sound outlet port;a motor disposed at least partially inside the housing, the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm; andan acoustic seal between the first front volume and the second back volume, the acoustic seal accommodating the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.2. The receiver of claim 1 , an acoustic impedance of the acoustic seal is greater than an acoustic impedance of the first sound outlet port over a range of human detectable frequencies.3. The receiver of claim 2 , the housing having a wall portion separating the first front volume from the second back ...

SYSTEMS AND METHODS ALLOWING FOR RESERVOIR AIR BUBBLE MANAGEMENT

Various embodiments of the present invention are directed to limiting a presence of air bubbles in fluidic media in a reservoir. Air passages may allow air to escape from fluidic media in a reservoir. Membranes may allow for trapping air bubbles in fluidic media before fluidic media enters a reservoir. A membrane may allow air to flow from a first reservoir containing fluidic media to a second reservoir while plunger heads within each of the reservoirs are moved within the reservoirs. An inner reservoir with a membrane may be moveable within an outer reservoir to allow air to move from the outer reservoir to the inner reservoir. An inner reservoir containing pressurized gas may allow fluidic media to be transferred to an outer reservoir.

ADJUSTABLE SNOW PLOW

An adjustable snow plow having a center unit; at least one extender wing; a square channel connected to said center unit; at least one mounting bracket connected to said center unit wherein the at least one extender wing is connected to the center unit via the square channel, and the mounting bracket is selectably attachable to a vehicle. 1. An adjustable snow plow comprising:a. a center unit;b. at least one extender wing;c. a square channel connected to said center unit, and;d. at least one mounting bracket connected to said center unit;wherein the at least one extender wing is connected to the center unit via the square channel, the at least one extender wing is able to slide horizontally about the square channel, and the at least one mounting bracket is selectably attachable to a vehicle.2. The adjustable snow plow of wherein the at least one extender wing is adjustable by way of sliding horizontally about the square channel so as to change the effective width of the snow plow.3. The adjustable snow plow of wherein the horizontal movement of the at least one extender wing about the square channel is controlled by a hydraulic actuator.4. The adjustable snow plow of wherein the horizontal movement of the at least one extender wing about the square channel is controlled manually.5. The adjustable snow plow of wherein the blade of the plow is able to be raised and lowered relative to the ground located below the plow such that opposing distal ends of the plow remain in the same horizontal plane.6. The adjustable snow plow of wherein the blade of the plow is able to be raised and lowered relative to the ground located below the plow in a manner which causes one end of the plow to be raised higher than the opposing end claim 1 , resulting in opposing distal ends of the plow to no longer remain in the same horizontal plane.7. The adjustable snow plow of wherein the blade of the plow is able to extend further away from claim 1 , or retract closer to claim 1 , the vehicle ...

Calibration Of Portable Devices In A Shared Virtual Space

Methods, systems, and computer programs for generating an interactive space, viewable through at least a first and a second handheld devices, are presented. The method includes an operation for taking an image with a camera in the first device. In addition, the method includes an operation for determining a relative position of the second device with reference to the first device, based on image analysis of the taken image to identify a geometry of the second device. Furthermore, the method includes operations for identifying a reference point in a three-dimensional (3D) space based on the relative position, and for generating views of an interactive scene in corresponding displays of the first device and the second device. The interactive scene is tied to the reference point and includes virtual objects, and each view shows all or part of the interactive scene as observed from a current location of the corresponding device. 1. A method for generating an interactive space viewable through at least a first device and a second device , the method comprising:taking an image with a camera in the first device, wherein the first device and the second device are handheld devices;determining a relative position of the second device with reference to the first device based on image analysis of the image to identify a geometry of the second device;identifying a reference point in a three-dimensional (3D) space based on the relative position; andgenerating views of an interactive scene in corresponding displays of the first device and the second device, wherein the interactive scene is tied to the reference point and includes virtual objects, each view showing all or part of the interactive scene as observed from a current location of the corresponding device.2. The method as recited in claim 1 , wherein determining the relative position further includes:identifying an outline of the second device in the image.3. The method as recited in claim 2 , wherein determining the ...

Measuring contact center agent effectiveness using a predictive model

An agent's performance is measured using a predictive model calculating an expected probability of success for each outbound communication, such as a call, handled by the agent that has reached the desired (“right”) party. An agent's cumulative actual performance value is maintained based on each “successful” contact, as indicated by a disposition code provided by the agent. A cumulative expected probability value of a “successful” communication is also maintained based on each call that reaches the right party where the expected probability of a “successful” call is determined by the predictive model. The agent's performance value can be determined by comparing the cumulative actual performance value with the cumulative expected probability of success value. The agent's performance value can then be compared to the performance value of other agents to identify agents performing above-expectations or below-expectations.

Systems and methods for processing and transmitting sensor data

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

TRACKING POSITION OF DEVICE INSIDE-OUT FOR VIRTUAL REALITY INTERACTIVITY

Methods, systems, and computer programs are provided for generating an interactive space. One method includes operations for associating a first device to a reference point in 3D space, and for calculating by the first device a position of the first device in the 3D space based on inertial information captured by the first device and utilizing dead reckoning. Further, the method includes operations for capturing images with a camera of the first device, and for identifying locations of one or more static features in the images. The position of the first device is corrected based on the identified locations of the one or more static features, and a view of an interactive scene is presented in a display of the first device, where the interactive scene is tied to the reference point and includes virtual objects. 1associating a first device to a reference point in a three-dimensional (3D) space using a camera of the first device;calculating by the first device a position of the first device in the 3D space based on inertial information captured by the first device;identifying locations of one or more static features in the images;correcting the position of the first device based on the identified locations of the one or more static features.. A method comprising: This application is a Continuation Application under 35 USC §120 and claims priority from U.S. application Ser. No. 14/260,208, filed Apr. 23, 2014 entitled “Calibration of Portable Devices in a Shared Virtual Space”, which claims priority from U.S. application Ser. No. 14/017,208, filed Sep. 3, 2013, entitled “Calibration of Portable devices in a Shared Virtual Space,” which is a Continuation Application under 35 USC §120 and claims priority from U.S. application Ser. No. 12/973,827 entitled “Calibration of Portable devices in a Shared Virtual Space,” filed on Dec. 20, 2010, which claims priority from U.S. Provisional Patent Application No. 61/311,251, filed Mar. 5, 2010, entitled “MAINTAINING MULTIPLE VIEWS ...

Manufacturing computer systems with fine line circuitized substrates

The present invention provides a method for electrolessly depositing metal onto a substrate, comprising: exposing a surface of the substrate to a first solution including a surfactant; and exposing the surface, having residual surfactant from the first solution thereon, to a second solution including ions of an electroconductive metal element for plating the surface with the electroconductive metal while exposed to the second solution; wherein the surface is exposed to the first solution immediately prior to exposing the surface to the second solution.

Display screen or portion thereof of a human capital management system with graphical user interface

Dispenser for flattened articles

A substantially moisture-proof, airtight dispenser for both storing and dispensing several flattened articles such as diagnostic test strips. The inventive dispenser includes a novel pivotable housing that a user need merely grab and squeeze to eject a test strip. Independent movement of the user's fingers to push a button or turn a knob is unnecessary to dispense a strip, which makes the present invention well suited for diabetics suffering from nerve damage in their extremities and other complications resulting from the disease. The invention includes a novel flexible arm member and pusher head that engage and push an article from the dispenser as the two parts of the housing are pivoted together. The articles are dispensed through an exit that is configured with a novel flexible seal that maintains the dispenser substantially airtight. Several inventive seal embodiments and methods of making the same are disclosed.

MULTI-PORT WIND NOISE PROTECTION SYSTEM AND METHOD

A system method provides for multi-port wind noise protection. A sound may include a desired component such as speech and an undesired component such as wind. Multiple apertures on a housing receive the sound and conduct it to a microphone. The undesired component such as wind is uncorrelated at the apertures and mixes at the microphone, attenuating in amplitude while the desired component such as speech is correlated at the apertures. In this manner, the signal to noise ratio between the desired component and undesired component is improved at the microphone. 1. An audio device comprising:a housing comprising an external surface at least partially enclosing a cavity;a microphone having an opening in communication with the cavity;a first aperture defined through the external surface and connected to a first passageway for a sound through the external surface and to the cavity, wherein the sound comprises a speech component and a wind component; anda second aperture defined through the external surface and connected to a second passageway for the sound through the external surface and to the cavity,wherein the first aperture and the second aperture are spaced apart on the external surface a first distance,wherein the first passageway conducts the sound along a first path to the cavity and the second passageway conducts the sound along a second path to the cavity, whereby the wind component is attenuated at the microphone relative to the speech component.2. The audio device of claim 1 , further comprising:a third aperture defined through the external surface and connected to a third passageway for the sound through the external surface and to the cavity,wherein the third aperture is spaced apart from the first aperture and the second aperture on the external surface,wherein the third aperture also is configured to receive the sound comprising the speech component and the wind component, andwherein the third passageway conducts the sound along a third path to the ...

AIR FILTER ARRANGEMENT; ASSEMBLY; AND, METHODS

Air filter cartridges are disclosed. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described. 130-. (canceled)31. An air filter cartridge comprising: (i) the filter media pack having a rectangular cross-sectional shape in a direction perpendicular to the central flow axis; and', '(ii) the filter media pack comprising four sides, including a first pair of first and second opposite sides and a second pair of first and second opposite sides, extending between the first flow face and the second flow face;, '(a) a filter media pack comprising filter media and having a first flow face and a second, opposite, flow face;'} (i) the first and second side pieces are molded in place; and', (A) the axial abutment surfaces are located beyond one of the first flow face and the second flow face of the filter media pack and facing in a direction away from the filter media pack; and', '(B) the axial abutment surfaces are constructed to engage an air cleaner housing, in use, to support the filter cartridge when the filter cartridge is installed in the air cleaner housing; and, '(ii) the first and second side pieces each comprise opposite edges, wherein at least one of the opposite edges of each of the first and second side pieces comprises an axial abutment surface, wherein], '(b) first and second side pieces positioned, respectively, on the first pair of first and second opposite sides of the filter media pack, wherein (i) the seal member includes a seal surface that forms an axially directed seal, in use; and', '(ii) the air cleaner housing engagement surfaces are non-parallel to the seal surface of the seal member., '(c) a housing seal arrangement for sealing the air filter cartridge to an air cleaner housing, in use, wherein32. An air filter cartridge according to wherein:(a) the filter media pack comprises alternating fluted media and facing media.33. An air filter cartridge according to ...

Delay locked loop

A delay locked loop includes a first delay device for obtaining a fine setting and a downstream-connected second delay device for obtaining a coarse setting of the delay time. The control signals for controlling the respective delay devices are provided by synchronization latches, which receive a clock obtained by the output signal of the first delay device for obtaining the fine setting. The delay locked loop enables a linear operating behavior at a high operating frequency and is particularly suitable when a differential embodiment of the two delay devices is used.

SEAL ARRANGEMENT FOR FILTER ELEMENT; FILTER ELEMENT ASSEMBLY; AND, METHODS

A filter cartridge arrangement is provided which includes a media pack comprising Z-filter media, a preform and a housing seal member. Improvements in the preform and seal member are described which include: a single beveled surface of the seal member to facilitate installation; and, an inside region of the seal member having a tip adjacent in inwardly directed lip of the preform, to control flash during molding. A variety of media pack configurations and features are described. 119-. (canceled)20. An air filter cartridge comprising: (i) the media pack comprising filter media defining a set of inlet flutes and a set of outlet flutes extending between the inlet end and the outlet end;', '(ii) the media pack being closed to flow of unfiltered air therethrough without passage through filter media of the media pack; and', '(iii) the media pack having a racetrack shaped periphery;, '(a) a media pack including an inlet end and an opposite outlet end (i) the seal member including a portion thereof molded around the periphery of the media pack; and', '(ii) the seal member including a radially directed seal surface for forming a radial seal with a seal surface of an air cleaner housing; and, '(b) a seal member positioned on an end of the media pack;'} (i) at least one fingertip receiving region located between the media pack and the preform and sized to receive fingertips to facilitate handling of the air filter cartridge during installation and removal from an air cleaner housing; and', '(ii) the preform extending around the periphery of the media pack., '(c) a preform mounted on an end of the media pack opposite the seal member;'}21. An air filter cartridge according to wherein:(a) the seal member portion molded around the outer periphery of the media pack is located at the outlet end of the media pack, and the preform extending around the periphery of the media pack is located at the inlet end of the media pack.22. An air filter cartridge according to wherein:(a) the at ...

Laminate Facing for Fiber Reinforced Materials and Composite Materials Formed Therefrom

The present invention provides a laminate material having a polyester film and a web of polyester fibers cohesively bonded directly thereto, such that portions of the fibers are bonded to the polyester film and portions of the fibers are free from the polyester film. The invention may also include a glass reinforced polymer layer formed on the laminated facer where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. The laminate may further include a second polymer layer having a thickness joined to the fiber layer and/or a layer of hot melt adhesive applied to the polyester fibers. Also presented is a composite material having a polyester film, a layer of polyester fibers bonded to the second polymer layer; a second polymer layer joined to the polyester film; and a glass reinforced polymer layer formed on the laminated facer, where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. 1. A laminate material comprising:a base layer of a polymer filma heat sealable polymer film having a thickness of 0.5-5 mil, anda bonded fiber web having a density of 17-100 GSM and including polymer fibers cohesively bonded directly thereto, such that portions of the fibers are bonded to the polymer film and portions of the fibers are free from the polymer film.2. The laminate material of claim 1 , wherein the polymer film is a polyester film.3. The laminate material of claim 1 , wherein the polymer film is a polyethylene terephthalate film.4. The laminate material of claim 1 , wherein the polymer fibers comprise polyester.5. The laminate material of claim 1 , wherein the polymer polyethylene terephthalate.6. The laminate material of claim 1 , wherein the polymer film is selected from the group consisting of polyethylene claim 1 , polyvinylidene fluoride claim 1 , poly(methyl methacrylate) claim 1 , polycarbonate claim 1 , acrylonitrile butadiene styrene claim 1 , polyvinyl ...

Sliding and tilting door assembly

A cooking appliance includes an outer cabinet within which is provided an oven cavity which can be selectively accessed by movement of a door mounted through a door linkage system which enables the door to be shifted between opened and closed positions through either sliding or tilting movements. In particular, the door can be automatically or manually shifted between open and closed positions, through either the sliding or tilting motions. In accordance with another aspect of the invention, the door can be automatically opened at the end of a process or cooking cycle, or manually opened.

Air cleaner arrangements; components; and, methods

An air cleaner assembly and components therefor are described. The components include features of an air cleaner housing; advantageous main filter cartridges; and, advantageous safety filter cartridge features. Features of the main filter cartridge are provided to engage an access cover of the assembly, and a cartridge support within the housing, in a preferred manner. Methods of assembly and use are also described.

Microwave intensification system for a conveyorized microwave oven

A microwave oven includes an oven cavity arranged within a housing. The oven includes a door and a motorized conveyor belt for transporting food items through the oven cavity. A microwave energy intensification system is provided below the conveyor belt to concentrate and intensify a microwave energy field directed into the oven cavity in order to minimize temperature deviations within the food item.

Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

Fairlead latch device

A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures.

Shielding system for protecting select portions of a food product during processing in a conveyorized microwave oven

A conveyorized microwave oven incorporates a shielding system mounted within an oven cavity of the microwave oven. The shielding system is provided to prevent select portions of a food item traveling through the microwave oven from overheating relative to the remainder of the food item. The present invention is particularly adapted for use in connection with the tempering, cooking or thawing of parallelepiped or rectangular-shaped food items and includes a frame structure fixedly mounted within and traversing substantially the entire length of the oven cavity, with the frame structure having a generally rectangular cross-section defined by both microwave impermeable portions and microwave transmissive portions on each side.

Fastener tool

The fastener tool includes a nosepiece, a nosepiece cover pivotally attached to the nosepiece, a latch pivotally attached to the nosepiece cover, a latch wire pivotally attached to the latch for engaging at least one hook disposed on the nosepiece, wherein the latch wire has a portion extending between the latch and the hook, the portion having at least two bends.

Type II broadband or polychromatic LED's

An LED is provided comprising two or more light-emitting Type II interfaces wherein at least two of the Type II interfaces differ in transition energy by at least 5%, or more typically by at least 10%, and wherein at least one of the Type II interfaces is within a pn junction. Alternately, an LED is provided comprising two or more light-emitting Type II interfaces wherein at least two of the Type II interfaces differ in transition energy by at least 5%, or more typically by at least 10%. The Type II interfaces may include interfaces from a layer which is an electron quantum well and not a hole quantum well, interfaces to a layer which is a hole quantum well and not an electron quantum well; and interfaces that satisfy both conditions simultaneously. The Type II interfaces may be within a pn or pin junction or not within a pn or pin junction. In the later case, emission from the Type II interfaces may be photopumped by a nearby light source. The LED may be a white or near-white light LED ...

Mobile-device directed conference calling

A method for mobile-device directed conference calling comprises receiving information from a subscriber of a mobile-communication service, communicating an access number and providing executable instructions to the mobile-communication device that expose a conference service to the subscriber, wherein when the subscriber selects an option from the mobile-communication device, the mobile-communication device initiates a call to a conference service that uses automatic number identification to authenticate the subscriber and connect the call with a teleconference bridge. A system comprises a processor, interfaces in communication with the public telephone network and a data network, respectively, and a memory. The system receives information from a subscriber of a mobile-communication service, communicates an access number to the subscriber and configures the mobile-communication device to expose a conference service to the subscriber. When the subscriber selects an option, the subscriber ...

Filter Arrangements; Housing; Assemblies; and, Methods

An air cleaner and preferred components for an air cleaner are provided. In one arrangement, the air cleaner includes a band or cassette component, configured for removably receiving a z-filter media pack therein, during use. In another arrangement, the band is permanently mounted of the media pack. Air cleaner arrangements configured for use of the cassette or band therewith included an arrangement with a central housing section for receipt of the main filter cartridge and cassette, and which has thereon a mounting arrangement with 3 mountable sides. Preferred precleaner arrangements and outlet tube arrangements can be secured to the center housing section.

Reduction of coal-fired combustion emissions

A process for mitigation of fouling deposits within a combustion zone, capturing of toxic metal emissions, and reduction of visible sulfur emissions attributable to sulfuric acid mist during coal combustion. SO3 formed during coal combustion is reduced by the addition to the coal of raw, unprocessed magnesium-containing minerals such as magnesite ore or brucite ore. The minerals are pulverized to a fine particle size and combined with pulverized coal to provide a mixture of the particles. The mixture is combusted and the ore particles calcine and decrepitate to very fine magnesium oxide particles that have a significant particle surface area. The magnesium oxide particles react with the SO3 produced during combustion of the coal and also capture toxic metals to reduce the quantity of undesirable stack discharge components.

Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

Dispenser for flattened articles

A substantially moisture-proof, airtight dispenser for both storing and dispensing several flattened articles such as diagnostic test strips. The inventive dispenser includes a novel pivotable housing that a user need merely grab and squeeze to eject a test strip. Independent movement of the user's fingers to push a button or turn a knob is unnecessary to dispense a strip, which makes the present invention well suited for diabetics suffering from nerve damage in their extremities and other complications resulting from the disease. The invention includes a novel flexible arm member and pusher head that engage and push an article from the dispenser as the two parts of the housing are pivoted together. The articles are dispensed through an exit that is configured with a novel flexible seal that maintains the dispenser substantially airtight. Several inventive seal embodiments and methods of making the same are disclosed.

Acoustic receivers with multiple diaphragms

Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.

Portable fluorescent drop-light

A hand-held fluorescent lamp assembly powered by typical line supply of 120 VAC, 60 Hz via an attached power cord and employing multiple commonly available fluorescent lamps. The assembly includes switches to independently control the multiple fluorescent lamps. The assembly includes lightweight solid state power regulation components. The power regulation circuit employs a self-oscillating circuit that is approximately matched in frequency of oscillation to the natural frequency of the fluorescent lamp load to automatically ignite the fluorescent lamps. The power regulation circuit includes circuit elements to automatically protect the ballast circuit and lamps from overdrawing in the run state and from abnormal load conditions.

Maintaining multiple views on a shared stable virtual space

Methods, apparatus, and computer programs for controlling a view of a virtual scene with a handheld device are presented. In one method, images of a real world scene are captured using a device. The method further includes operations for creating an augmented view for presentation on a display of the device by augmenting the images with virtual reality objects, and for detecting a hand in the images as extending into the real world scene. In addition, the method includes operations for showing the hand in the screen as detected in the images, and for generating interaction data, based on an interaction of the hand with a virtual reality object, when the hand makes virtual contact in the augmented view with the virtual reality object. The augmented view is updated based on the interaction data, which simulates on the screen that the hand is interacting with the virtual reality object.

AIR CLEANER ARRANGEMENTS; COMPONENTS; AND, METHODS

An air cleaner assembly and components therefor are described. The components include features of an air cleaner housing; advantageous main filter cartridges; and, advantageous safety filter cartridge features. Features of the main filter cartridge are provided to engage an access cover of the assembly, and a cartridge support within the housing, in a preferred manner. Methods of assembly and use are also described. 1. An air filter cartridge for removable installation in a housing; the air filter cartridge comprising:(a) a media pack comprising media surrounding an open interior; the media having first and second ends; (i) the first end cap having a central aperture therethrough;', '(ii) the first end cap having a first seal portion oriented to form a first, radially outwardly directed, releasable radial seal with the housing section;', '(iii) the first end cap having a second radial seal portion oriented to form a second, radially outwardly directed, seal with the housing at an opposite side of the joint from the first releasable radial seal; and,', '(iv) the first and second, radially outwardly directed, seal portions being configured to form seals that differ from one another, in largest cross-dimension, by at least 2 mm; the first seal portion having a larger cross-dimension, than any portion of the second seal portion;', '(v) the first seal portion being at a perimeter of the first end cap;', '(vi) the filter cartridge having no structure thereon that is both located adjacent the first end cap and that has a larger cross-dimension than the cross-dimension of the first seal portion; and,, '(b) a first end cap positioned on the media first end;'}(c) a second end cap positioned on the media second end.2. An air filter cartridge according to wherein:(a) the media pack has a conical shape with a larger end adjacent the first end cap and a smaller end adjacent the second end cap.3. An air filter cartridge according to wherein:(a) the second radial seal portion has a ...

Inhibitors of plasma kallikrein and uses thereof

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Filter arrangements; housings; assemblies; and, methods

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a seal thereon.

Trajectory guide with instrument immobilizer

A method and apparatus accurately maintains alignment of a surgical instrument. The apparatus includes a base with an attached movable member. The movable member includes a passage forming a portion of a trajectory path. A relaxable or rigid material has a similar passage in common with the passage of the movable member. If a relaxable material is used, the passage portion of the relaxable region is held open by an inserted stem removably attached to the movable member. The instrument is then inserted into the center of the stem and thus into the trajectory path. The stem is removed by withdrawing it from the movable member over the proximal portion of the instrument. This releases the relaxable region to tightly hold the instrument in place. Alternatively, using a relaxable or rigid component, the component is slid laterally to at least partially offset a passage through the component from the passage of the movable member to reduce a combined effective area of the passages and to grasp ...

FAIRLEAD LATCH DEVICE

A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures. 1. A fairlead latch device for guiding and securing an anchor chain , the fairlead latch device comprising:a fairlead housing pivotally coupled to an offshore structure, wherein said fairlead housing comprises an upper retainer component coupled to an upper support structure attached to said offshore vessel, said upper retainer component configured to provide said pivotal coupling;wherein said fairlead housing is configured to receive and guide an anchor chain during deployment or retrieval of said anchor chain between said vessel and an anchor;a latch housing pivotally mounted to said fairlead housing, wherein said latch housing extends away from said fairlead housing;a latch mechanism mounted to said latch housing, wherein said latch device includes a ratchet assembly; andan actuator for operating said ratchet assembly.2. The fairlead latch device according to claim 1 , wherein said fairlead housing is configured to guide an anchor chain using a guide structure selected from the group consisting of a chain wheel claim 1 , a smooth wheel claim 1 , and a bending shoe.3. The fairlead latch device according to claim 1 , wherein said ratchet assembly comprises at least two latches rotatably mounted to said latch housing.4. The fairlead latch device according to claim 3 , wherein said ratchet assembly comprises an hydraulic actuator for operating ...

Methods for identifying, diagnosing, and predicting survival of lymphomas

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.

Surgical Snare with Electrosurgical Tip and Method of Use

A medical device includes a tissue dissector and a snare loop on a common shaft. At least the distal tip of the snare loop is energizable to function as an electrosurgical element for tissue dissection. In use the snare loop is partially extended from the shaft to expose the electrosurgical element for electrosurgical dissection, and the snare loop is fully extended from the shaft to deploy the snare loop for retrieval and positioning of an implant such as a gastric banding device. The snare loop may be deployed through a pair of jaws also mounted on the shaft for use in tissue dissection.

DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS

The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included. 2. The compound according to wherein Ris bonded to one of the nitrogen atoms of the pyrazole ring and represents a hydrocarbon group of 1-5 carbon atoms which is optionally substituted with up to 3 halogen atoms or hydroxy.3. The compound according to wherein Ar represent phenyl claim 2 , which bears 0-3 substituents independently selected from R.4. The compound according to wherein Ar represents 4-CF-phenyl.5. The compound according to wherein Ris bonded to one of the nitrogen atoms of the pyrazole ring and represents ethyl.6. The compound according to wherein A represents —C(R)(R)— and B represent H.7. The compound according to wherein Rand Rare methyl.8. The compound according to wherein Rand Rare joined together with the atom to which they are attached to form cyclopropyl claim 6 , cyclobutyl or oxetanyl.10. The compound according to wherein X represents a bond.11. The compound according to wherein Rrepresent CF—CH—.12. The compound according to wherein X represents NR.13. The compound according to wherein Y and Z each represent CH.14. The compound according to wherein:Y and Z each represent CH;{'sup': '8', 'Ar represent phenyl, which bears 0-3 substituents independently selected from R;'}{'sup': '3', 'Rrepresents H;'}{'sup': '6', 'Ris bonded to one of the nitrogen atoms of the pyrazole ring and represents ethyl;'}{'sup': '7', 'Rrepresents H;'}{'sup': 4', '5, 'A represents —C(R)(R)— and B represent H;'}{'sup': 4', '5', '4', '5, 'Rand Rare methyl or Rand Rare joined together with the atom to which they are attached to form cyclopropyl, cyclobutyl or oxetanyl; and'}{'sup': '2', 'X ...

METHOD AND APPARATUS FOR MANIPULATING CHAIN SEGMENTS

A chain wheel designed to haul in, pay out and/or guide a mooring chain that includes multiple chain sizes. In one configuration, the chain wheel is a dual chain wheel that includes pockets sized to support a larger chain size and pockets sized to support a smaller chain size. The pockets include flat surfaces that support links of the chain as it passes over the chain wheel. The chain wheel also includes whelps designed to support and guide chain segments into proper alignment with the chain wheel. 1. A chain wheel comprising;a wheel hub;a first outer wildcat profile positioned about the hub;a second outer wildcat profile positioned about the hub in spaced relation with the first outer wildcat profile;a first inner wildcat profile positioned about the hub and generally adjacent the first outer wildcat profile; anda second inner wildcat profile positioned about the hub in spaced relation with the first inner wildcat profile and generally adjacent the second outer wildcat profile.2. The chain wheel of claim 1 , wherein the pair of outer wildcat profiles is adapted to engage a first chain segment size and the pair of inner wildcat profiles is adapted to engage a second chain segment size.3. A chain wheel as in claim 1 , wherein each of the wildcat profiles has a plurality of whelps claim 1 , and wherein pairs of spaced-apart whelps are adapted to position chain segments between pairs of wildcat profiles.4. A chain wheel as in claim 3 , wherein the whelps of the first and second inner wildcat profiles are aligned with respective whelps of the first and second outer wildcat profiles.5. A chain wheel as in claim 1 , wherein each of the inner wildcats is rotatably adjustable about the hub relative to an outer wildcat.6. A chain wheel as in or claim 1 , further comprising radiused pockets formed between adjacent whelps for accommodating horizontally disposed links.7. A chain wheel comprising a rim;a first wildcat profile attached to the rim; anda second wildcat profile ...

SPIROCYCLIC COMPOUNDS

The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The present invention further provides pharmaceutical compositions comprising the compounds of the instant invention and safe dosing regimens of these pharmaceutical compositions, which are easy to follow, and which result in a therapeutically effective amount of these compounds in vivo. 6. A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to any one of to , and a pharmaceutically acceptable carrier.7. The use of the compound according to any one of to for the preparation of a medicament useful in the treatment or prevention of cancer in a mammal. This application is a divisional application of U.S. application Ser. No. 12/085,396, which is a §371 application of PCT/US06/044754 that was filed on Nov. 17, 2006, which claims priority from the U.S. Provisional Application No. 60/739,324, filed on Nov. 23, 2005, now expired.The present invention relates to a novel class of substituted spirocyclic compounds. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present ...

SYSTEM AND METHODOLOGY FOR PROVIDING SHIRT COLLAR SUPPORT

Aspects for supporting a turndown shirt collar are disclosed. In a particular aspect, a semi-rigid shapeable device includes a rear region that forms a substantially semi-circle shape having a first and second end. For this particular embodiment, each of a first terminal end and a second terminal end are respectively oriented upwards and inwards relative to the rear region via a first bend at the first end and a second bend at the second end. In another aspect, a method that facilitates forming a shirt collar support is provided, which includes shaping a semi-rigid shapeable device into a substantially semi-circle shape. In a further aspect, a turndown collared shirt is provided, which includes a collar band comprising at least one collar sleeve configured to hold a shaping device. 1. A semi-rigid shapeable device , comprising:a rear region, wherein the rear region is configured to form a substantially semi-circle shape having a first end and a second end; and a first portion extending from the first end to a first terminal end, wherein the first portion forms a first bend at the first end, and wherein the first bend is configured to orient the first terminal end upwards and inwards relative to the rear region; and', 'a second portion extending from the second end to a second terminal end, wherein the second portion forms a second bend at the second end, and wherein the second bend is configured to orient the second terminal end upwards and inwards relative to the rear region., 'an ends region, wherein the ends region includes2. The semi-rigid shapeable device according to claim 1 , wherein the rear region includes a squared edge opposite to an open region of the substantially semi-circle shape.3. The semi-rigid shapeable device according to claim 2 , further comprising a rear bend at a midpoint of the squared edge claim 2 , wherein the rear bend is configured to orient the midpoint upwards relative to opposite halves of the squared edge.4. The semi-rigid shapeable ...

Dynamic Control System for a Magnetron Tube in a Microwave Oven

A microwave oven having a cabinet, a door, a programming interface, a magnetron tube that capable of being dynamically controlled, a controller configured to control the magnetron tube, and a microwave generating system is described. A method of dynamically controlling the magnetron tube in the microwave oven by utilizing a magnetron power supply is also described. By monitoring a current to the magnetron power supply, determining the current to the magnetron power supply at which the magnetron tube conducts, calculating a time base, and adjusting the time base as the power level required is increased, the control produces consistent power when the magnetron tube is cycled at less than a 100% power level and to compensate for a slow start of the magnetron tube during a short cook cycle. 1. A method of dynamically controlling a magnetron tube in a microwave oven utilizing a magnetron power supply comprising:monitoring a current to the magnetron power supply;determining the current to the magnetron power supply at which the magnetron tube conducts;calculating a time base; andadjusting the time base as the power level required is increased, to produce consistent power when the magnetron tube is cycled at less than a 100% power level and to compensate for a slow start of the magnetron tube during a short cook cycle.2. A method as claimed in claim 1 , wherein calculating the time base is based on a tube start time.3. A method as claimed in claim 1 , wherein calculating the time base is based on a microwave power level value that a user selects for the microwave oven.4. A method as claimed in claim 1 , wherein calculating the time base is based on a tube start time and a microwave power level value that a user selects for the microwave oven.51. A method as claimed in claim 1 , wherein calculating the time base includes employing a polynomial to prevent the cycle time from becoming excessively long.65. A method as claimed in claim 1 , wherein calculating the time base ...

Modulators of ATP-binding cassette transporters

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject. 111.-. (canceled)12. A method for treating a diffuse large B cell lymphoma (DLBCL) in a subject comprising:(a) isolating gene expression product from a DLBCL biopsy sample from a subject with DLBCL;(b) determining an average gene expression level of genes set forth in Table 2371 for the proliferation gene expression signature to obtain a proliferation gene expression signature value;(c) determining an average gene expression level of genes set forth in Table 2371 for the germinal center B cell gene expression signature to obtain a germinal center B cell gene expression signature value;(d) determining an average gene expression level of genes set forth in Table 2371 for the MHC class II gene expression signature to obtain an MHC class II gene expression signature value;(e) determining an average gene expression level of genes set forth in Table 2371 for the lymph node gene expression signature to obtain a lymph node gene expression signature value;(f) measuring the expression level of BMP6 to obtain a BMP6 expression value;(g) determining a survival predictor score calculated as [0.241* (proliferation gene expression signature ...

Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Filter arrangements; housings; assemblies; and, methods

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a seal thereon.

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:A is substituted or unsubstituted heteroarylene.3. The compound of or claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:A is substituted or unsubstituted 5-6 membered heteroarylene.4. The compound of or claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:A is substituted or unsubstituted 5-membered heteroarylene.5. The compound of any one of - claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 'A', '#text': 'each occurrence of Ris, independently, hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, a nitrogen protecting group when attached to a nitrogen atom, or an oxygen protecting group when attached to an oxygen atom.'}6. The compound of any one of - claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 'A', '#text': 'each occurrence of Ris, independently, hydrogen, substituted or unsubstituted alkyl, or a nitrogen protecting group.'}7. The compound of any one of - claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '1', 'sub': '2', '#text': 'Ris —NH.'}8. The compound of any one of - claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': ['2', 'A', 'A'], 'sub': '2', '#text': 'Ris substituted or unsubstituted aryl, substituted or unsubstituted ...

Retrieval Device

A retrieval device may include a first plate and a second plate which may be movably coupled to a body via a first body fastener and a second body fastener, respectively. An upper plate connector and a lower plate connector may each be movably coupled to the first plate and a second plate with the lower plate connector positioned between the upper plate connector and the body fasteners. An optional tensioner may tension portions of the first plate and a second plate together. Upper gripper(s) may be coupled to the upper plate connector and lower gripper(s) may be coupled to the lower plate connector. The device may be movable between an open position, in which the upper gripper(s) and lower gripper(s) are positioned relatively distally from each other, and a closed position, in which the upper gripper(s) and lower gripper(s) are positioned relatively proximate to each other. 1. A retrieval device , the device comprising:a first plate movably coupled to a body via a first body fastener;a second plate movably coupled to the body via a second body fastener;an upper plate connector movably coupled to the first plate and to the second plate;a lower plate connector movably coupled to the first plate and to the second plate, wherein the lower plate connector is coupled to the first plate between the upper plate connector and the first body fastener, and wherein the lower plate connector is coupled to the second plate between the upper plate connector and the second body fastener;a first upper gripper coupled to the upper plate connector; anda first lower gripper coupled to the lower plate connector, wherein the device is movable between an open position, in which the first upper gripper and first lower gripper are positioned relatively distally from each other, and a closed position, in which the first upper gripper and first lower gripper are positioned relatively proximate to each other.2. The device of claim 1 , further comprising a tensioner that is configured to ...

Systems and Methods for Providing Access Security, Anonymization, and Compliance Evaluation for Enterprise Data

A system for evaluating employee credit information in view of occupation level policies configures occupation specific policies indicative of relevant patterns of credit profile changes, determines whether patterns of received credit profile changes violate the configured occupation level policies, and, based on the determination, stores the credit profile changes as a non-violation or provides for a user with permission-based access to review the corresponding employee credit bureau credit file. A system for anonymizing employee investigative consumer report information received by an employer limits a presentation of the employee investigative information to meta data about a specified offense without exposing personally identifiable information. A system for evaluating employee credit information in view of credit information regulatory law and occupation specific policies provides an automated compliance function that evaluates an eligibility of an employee for credit evaluation based on internal policies of an employer to ensure legal regulatory compliance.

FILTER ARRANGEMENTS; HOUSINGS; ASSEMBLIES; AND, METHODS

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a seal thereon. 119-. (canceled)20. An air filter cartridge comprising:{'claim-text': ['(i) an inlet flow end and an opposite outlet flow end;', '(ii) filter media extending between the inlet flow end and the opposite outlet flow end; and,', '(iii) opposite curved ends separated by opposite sides; and,'], '#text': '(a) a filter media pack having:'}{'claim-text': ['(i) the housing seal arrangement comprising a seal member; and,', '(ii) the seal member comprising a seal surface having a racetrack shape comprising opposite curved ends separated by opposite sides; and,'], '#text': '(b) a radially outwardly directed housing seal arrangement secured around a periphery of the media pack;'}{'claim-text': ['(i) the band having a first end, a second end, and two opposite sides extending between the band first end and the band second end;', '(ii) the band having a ramp-engagable portion for engagement with an air cleaner housing ramp during installation of the filter cartridge into an air cleaner housing;', '(iii) the band being permanently mounted around the periphery of the filter media pack; and,', {'claim-text': '(A) the projection arrangement on the band comprising a handle; and,', '#text': '(iv) the band having a projection arrangement to provide for grasping of the band during handling of the air filter cartridge; the projection arrangement being in overlap with one of the band first end and the band second end and not in overlap with the other of the band first end and the band second end, and not in overlap with the two band opposite sides;'}, '(v) the band being spaced from, and separate from, the seal member.'], '#text': '(c) a band extending around a periphery of the media pack;'}21. An air filter cartridge arrangement according to wherein:(a) the projection ...

ANTI-FIBROTIC COMPOUNDS

Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound KIN or composition described herein. (Formula (I)) 235-. (canceled)36. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , whereinG is hydrogen;m is H or 2; and{'sup': '6', 'each occurrence of Ris, independently, F or Cl.'}37. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': '7', 'G is C(O)R;'}m is 0;{'sup': 7', '9, 'Ris NHR; and'}{'sup': '9', 'Ris tetrazolyl, pyridinyl, pyrazolyl, imidazolyl, or triazolyl, each of which is optionally substituted with up to two alkyl groups.'}40. The compound of claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , whereinX is O;{'sup': '10', 'Y is NR; and'}{'sup': '10', 'sub': '1-4', 'Ris Calkyl.'}41. The compound of claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein{'sup': '10', 'X is NR; and'}Y is O.42. The compound of claim 39 , or a pharmaceutically acceptable salt thereof claim 39 , wherein Rand Rtogether with the carbon atom to which they are attached form a carbonyl.44. A compound selected from the group consisting of:(E)-N-(2-fluorophenyl)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamide (1);(E)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-N-(2-(5-methyl-1H-1,2,4-triazol-3-yl)phenyl)acrylamide (2);(E)-N-(2-chlorophenyl)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamide (3);(E)-N-(2-bromophenyl)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamide (4);(E)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)-N-(o-tolyl)acrylamide (5);(E)-N-(2-cyanophenyl)-3-(3-methoxy-4-(prop-2-yn-1-yloxy)phenyl)acrylamide (6);(E)-N-(3,4-dichlorophenyl)-3-(3- ...

Photoreal character configurations for spatial computing

Systems and methods for displaying a virtual character in a mixed reality environment are disclosed. In some embodiments, a view of the virtual character is based on an animation rig comprising primary joints and helper joints. The animation rig may be in a pose defined by spatial relationships between the primary joints and helper joints. The virtual character may be moving in the mixed reality environment. In some instances, the virtual character may be moving based on a comparison of interestingness values associated with elements in the mixed reality environment. The spatial relationship transformation associated with the movement may be indicated by movement information. In some embodiments, the movement information is received from a neural network.

Expandable Containment Plow

Provided is a material handling assembly, such as a plow, that may contain additional features mounted thereon so as to increase the functionality of the assembly, and an apparatus and method for mounting such an assembly or other like structure onto a vehicle, such as a truck. A plow mounting apparatus may be used for automatically mounting and dismounting a plow blade to an end of an associated vehicle. The plow mounting apparatus includes a plow assembly comprising: an expandable plow blade pivotally attached to a front portion of a plow frame; a lift frame attached to a rear portion of the plow frame; an auxiliary light mounting apparatus attached to the plow frame; and a height adjustment mechanism that is operable to raise and lower the plow blade assembly relative to the ground. The height adjustment mechanism may include a hydraulic cylinder having a top portion and a bottom portion. The vertical pull structure is attached to the lift frame and includes an outer vertical sleeve and an inner vertical member which is slidingly engageable with the outer vertical sleeve. The light mounting apparatus includes a cross member affixed to a lift frame of a plow assembly and first and second horns which are positioned within the interior of the first and second ends of the cross member such that they are adjustable by way of a fastener. 1. An adjustable auxiliary light mounting apparatus being affixed to a plow mounting apparatus for mounting a material handling box assembly on an associated vehicle , such as a truck , comprising:a lift frame having a first side member and a second side member;a cross member positioned between the first side member and the second side member of the lift frame, wherein the cross member has a first end and a second end having an inner diameter and an outer diameter, and the cross member having at least one aperture at a first end and at least one aperture at a second end of the cross member;a first horn having a first end and a second ...

Method of Ultrasonically Bonding Paperboard

In a method of ultrasonically bonding paperboard, first and second pieces of paperboard are supplied, with at least one of the first and second pieces of paperboard being provided with a clay coating. The first and second pieces of paperboard are moistened and positioned in a gap between a sonotrode and an anvil of an ultrasonic welding unit. The ultrasonic welding unit is activated and the first and second pieces of paperboard are compressed between 30-70%, more preferably between 40-60%, to cause the clay coating to mobilize and force the clay coating material into fiber matrixes of the first and second pieces of paperboard, followed by cooling of the first and second pieces of paperboard, to bond the first and second pieces of paperboard. 1. A method of ultrasonically bonding paperboard comprising:supplying first and second pieces of paperboard, with at least one of the first and second pieces of paperboard being provided with a clay coating;moistening the first and second pieces of paperboard;positioning the first and second pieces of paperboard in a gap between a sonotrode and an anvil of an ultrasonic welding unit;activating the ultrasonic welding unit and compressing the first and second pieces of paperboard to cause the clay coating to mobilize and force the clay coating into fiber matrixes of the first and second pieces of paperboard in bonding the first and second pieces of paperboard, wherein the first and second pieces of paperboard are compressed between 30 and 70% during activation of the ultrasonic welding unit; andallowing the first and second pieces of paperboard to cool.2. The method of claim 1 , wherein:moistening the first and second pieces of paperboard causes starch from the first and second pieces of paperboard to gelatinize; andallowing the first and second pieces of paperboard to cool causes retrogradation of the starch.3. The method of claim 2 , wherein the first and second pieces of paperboard are moistened with water.4. The method of ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1. A method for transmitting data between devices of an analyte monitoring system , the method comprising:generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor;establishing a two-way communication channel between the sensor electronics module and the a display device and each of the sensor electronics module and display device transmitting at a first transmission power; andinitiating a low power transmission mode responsive to sensing user input at user interface of the display device indicative of entering the mode, wherein the low power transmission mode comprises one or both of the sensor electronics module and the display device transmitting at a second transmission power that is lower than the first transmission power.2. The method of claim 1 , wherein the initiating comprises the display device sending a command to the sensor electronics module to enter the low power mode.3. The method of claim 1 , wherein the display device prompts a user to input a duration of time for the low power transmission mode claim 1 , and wherein the display device and the sensor electronics module automatically exit the low power transmission mode after expiration of the duration of time.4. The method of claim 1 , further ...

FLEXIBLE FILM CONTAINER AND MANUFACTURING METHOD

A self-supporting flexible film container is disclosed that includes a container base and a flexible film attached to the container base that forms a container wall and defines a packing region within the container. The container wall has at least one support column, such as a tubular support column, integrally formed therein. A method of conforming the container includes providing a web of flexible film, forming tubular support columns in the web of flexible film and forming a container from the web of flexible film containing the support columns. The support columns can be formed by ploughing and forming the web of flexible film. 1. A container , comprising:a container base; anda flexible film attached to the container base forming a container wall and defining a packing region within the container, the container wall having at least one support column integrally formed therein.2. The container of claim 1 , wherein the support column is a tubular support column.3. The container of claim 1 , wherein the support column comprises one or more overlapping folds.4. The container of claim 1 , wherein the support column is oriented perpendicular to the container base.5. The container of claim 4 , wherein the support column extends from a bottom of the container to a top of the container.6. The container of claim 1 , wherein the support column is a flattened support column.7. The container of claim 1 , wherein the container wall is a polygon having at least three sides.8. The container of claim 7 , wherein the support column is formed in a corner of the container wall.9. The container of claim 8 , comprising support columns in each corner of the container wall.10. The container of claim 7 , wherein the container wall has four wall portions and four corners.11. The container of claim 1 , wherein the support column encloses a fluid material claim 1 , the support column being welded at opposing ends.12. The container of claim 11 , wherein the support column encloses a gas.13. ...

POSE ESTIMATION USING SEMATIC SEGMENTATION

Methods and systems for implementing artificial intelligence to determine the pose of a sample within a microscope system and aligning said sample are disclosed. An example method includes receiving an image of the sample in the microscope apparatus, accessing a template associated with the sample. The template describes a plurality of template key points of the template version of the sample. A plurality of key points on the sample are then determined, where each of the key points on the sample corresponds to a corresponding template key point of a sample template, and the key points are subsequently used to determine a transformation between the sample as depicted in the image and the template version of the sample as described in the template. The transformation can then be used to automate the alignment of the sample within the microscope. 1. A method for estimating position of a sample in a charged particle microscope apparatus , the method comprising:receiving an image of the sample in the charged particle microscope apparatus;accessing a template associated with the sample, the template describing a template version of the sample in a desired alignment, the template further including a plurality of template key points of the template version of the sample;determining a plurality of key points on the sample, each of the key points on the sample corresponding to a corresponding template key point of a sample template;determining, based on the key points and the corresponding template key points, a transformation between the sample in the image and the template version of the sample as described in the template; andcausing the sample to be aligned within the charged particle microscope apparatus based on the transformation.2. The method of claim 1 , wherein aligning the sample in the charged particle microscope apparatus comprises aligning the sample as part of a process in which a sub-sample/lamella is automatically formed.3. The method of claim 1 , wherein the ...

Modulators of Cystic Fibrosis Transmembrane Conductance Regulator

The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 120-. (canceled)21. A transcutaneous glucose sensor system comprising:a transcutaneous glucose sensor comprising an implantable portion, wherein the transcutaneous glucose sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, wherein the at least one electrode comprises a working electrode;a sensor electronics module operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics module comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor, wherein the circuitry comprises a battery; anda display device operatively connected to the sensor electronics module, wherein the display device is configured to display a glucose value;wherein the sensor electronics module is configured to monitor sleep current when the sensor electronics module is in a sleep mode; andwherein the sensor electronics module is further configured to determine whether an error has occurred with respect to a normal drain of the battery in the sleep mode based at least in part on the monitoring.22. The sensor system of claim 21 , wherein the sensor electronics module is configured to store information related to a detected error in a ...

Air filter arrangement; assembly; and, methods

An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and defining a media pack having opposite flow faces. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described.

Acoustic receivers with multiple diaphragms

Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a receiver housing with a first internal volume and a second internal volume, a first diaphragm separating the first internal volume into a first front volume and a first back volume such that the first front volume has a first sound outlet port, a second diaphragm separating the second internal volume into a second front volume and a second back volume such that the second front volume has a second sound outlet port, a motor disposed at least partially inside the housing such that the motor including an armature mechanically coupled to both the first diaphragm and the second diaphragm, an acoustic seal between the first front volume and the second back volume such that the acoustic seal accommodates the mechanical coupling of the armature to one of the first diaphragm or the second diaphragm.

Air Filter Arrangement; Assembly; and, Methods

An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and defining a media pack having opposite flow faces. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described. 131-. (canceled)32. An air filter cartridge comprising: (i) the filter media pack includes filter media arranged between the first flow face and the second, opposite, flow face;', '(ii) the filter media pack having a rectangular cross-sectional shape, in a direction perpendicular to a central flow axis extending in an axial direction between the first flow face and the second, opposite, flow face;', '(iii) the filter media pack comprising four sides extending between the first flow face and the second, opposite, flow face, wherein the four sides include a first pair of first and second opposite sides, and a second pair of first and second opposite sides, and the four sides form a periphery of the filter media pack;, '(a) a filter media pack having a first flow face and a second, opposite, flow face, wherein(b) end pieces over the first pair of first and second opposite sides of the filter media pack; and (i) a seal member comprising an axial pinch seal portion configured to be pinched between seal flanges on a housing, when the air filter cartridge is installed for use; and', '(ii) a trough on only one side of the housing seal arrangement and located inwardly of the axial pinch seal portion, wherein the trough has an opening facing in the axial direction toward the second flow face and is configured to receive a portion of an air cleaner assembly projecting therein when the air filter cartridge is installed for use., '(c) a ...

AIR FILTER ARRANGEMENT; ASSEMBLY; AND, METHODS

Air filter cartridges are disclosed. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described. 130-. (canceled)31. An air filter cartridge comprising: (i) the filter media pack having a rectangular cross-sectional shape in a direction perpendicular to the central flow axis; and', '(ii) the filter media pack comprising four sides, including a first pair of first and second opposite sides and a second pair of first and second opposite sides, extending between the first flow face and the second flow face;, '(a) a filter media pack comprising filter media and having a first flow face and a second, opposite, flow face;'} (i) the first and second side pieces are molded in place; and', (A) the first abutment surface and the second abutment surface of the first and second side pieces are located beyond one of the first flow face and the second flow face of the filter media pack and in a direction away from the filter media pack;', '(B) the first abutment surface and the second abutment surface of the first and second side pieces each extend a length and are constructed to engage an air cleaner housing, in use, to support the filter cartridge when the filter cartridge is installed in the air cleaner housing; and', '(C) the first abutment surface and the second abutment surface of the first side piece are spaced from each other, and the first abutment surface and the second abutment surface of the second side piece are spaced from each other; and, '(ii) the first and second side pieces each comprise a first abutment surface and a second abutment surface, wherein], '(b) first and second side pieces positioned, respectively, on the first pair of first and second opposite sides of the filter media pack, wherein (i) the seal member includes a seal surface that forms an axially directed seal, in use; and', '(ii) the first abutment surface and the second abutment surface of the first and ...

Avatar customization for optimal gaze discrimination

Examples of systems and methods for rendering an avatar in a mixed reality environment are disclosed. The systems and methods may be configured to automatically select avatar characteristics that optimize gaze perception by the user, based on context parameters associated with the virtual environment.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1a transcutaneous glucose sensor comprising an in vivo portion, wherein the transcutaneous sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, wherein the at least one electrode is a working electrode;a sensor electronics unit operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics unit comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor; anda display device operatively connected to the sensor electronics unit, wherein the display device is configured to display a glucose value.. A transcutaneous glucose sensor system, the system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/191,172, filed Mar. 3, 2021, which is a continuation of U.S. application Ser. No. 16/925,233, filed Jul. 9, 2020, now U.S. Pat. No. 10,985,804, which is a continuation of U.S. application Ser. No. 16/546,099, filed Aug. 20, 2019, now abandoned, which is a continuation of U.S. application Ser. No. 15/413,206, filed Jan. 23, 2017, now ...

Spinal stabilization systems with quick-connect sleeve assemblies for use in surgical procedures

In some embodiments, a spinal stabilization system may be formed in a patient using quick-connect sleeve assemblies. Each quick-connect sleeve assembly can be coupled to a bone fastener assembly in a fast and intuitive way. In one embodiment, a quick-connect sleeve assembly has a detachable member and a movable member. Both members engage a collar of the bone fastener assembly. In one embodiment, the engagement can be locked via one or more locking features to facilitate screwing a bone fastener of the bone fastener assembly onto a vertebral body in a minimally invasive surgical procedure. Each quick-connect sleeve assembly has a low profile and is particularly shaped for minimally invasive entry.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1. A method for transmitting data between devices of an analyte monitoring system , the method comprising:generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor;establishing a two-way communication channel between the sensor electronics module and the a display device and each of the sensor electronics module and display device transmitting at a first transmission power; andinitiating a low power transmission mode responsive to sensing user input at user interface of the display device indicative of entering the mode, wherein the low power transmission mode comprises one or both of the sensor electronics module and the display device transmitting at a second transmission power that is lower than the first transmission power.2. The method of claim 1 , wherein the initiating comprises the display device sending a command to the sensor electronics module to enter the low power mode.3. The method of claim 1 , wherein the display device prompts a user to input a duration of time for the low power transmission mode claim 1 , and wherein the display device and the sensor electronics module automatically exit the low power transmission mode after expiration of the duration of time.4. The method of claim 1 , further ...

Artificial Intelligence Enabled Metrology

Methods and systems for implementing artificial intelligence enabled metrology are disclosed. An example method includes segmenting a first image of structure into one or more classes to form an at least partially segmented image, associating at least one class of the at least partially segmented image with a second image, and performing metrology on the second image based on the association with at least one class of the at least partially segmented image. 1. A method comprising:segmenting a first image of structure into one or more classes to form an at least partially segmented image;associating at least one class of the at least partially segmented image with a second image; andperforming metrology on the second image based on the association with at least one class of the at least partially segmented image.2. The method of claim 1 , wherein associating at least one class of the at least partially segmented image with the second image includes associating on a pixel by pixel basis the at least one class of the segmented image with the second image.3. The method of claim 2 , wherein the at least one class is a key points class that designates key features of structure included in the second image.4. The method of claim 2 , wherein performing metrology on the second image based on the association of at least one class of the at least partially segmented image includes placing an edge finder on the second image based on the location of the at least one class.5. The method of claim 1 , wherein segmenting a first image into one or more classes includes classifying each pixel of the first image as belonging to one or more classes of a plurality of classes.6. The method of claim 5 , wherein the plurality of classes comprises a structure body claim 5 , a structure boundary claim 5 , and key points claim 5 , wherein the key points indicate key features of the structure for a basis of metrology.7. The method of claim 5 , wherein classifying each pixel of the first image ...

CALIBRATION OF PORTABLE DEVICES IN A SHARED VIRTUAL SPACE

Methods, systems, and computer programs are provided for generating an interactive space. One method includes operations for associating a first device to a reference point in 3D space, and for calculating by the first device a position of the first device in the 3D space based on inertial information captured by the first device and utilizing dead reckoning. Further, the method includes operations for capturing images with a camera of the first device, and for identifying locations of one or more static features in the images. The position of the first device is corrected based on the identified locations of the one or more static features, and a view of an interactive scene is presented in a display of the first device, where the interactive scene is tied to the reference point and includes virtual objects. 1. A method comprising:associating a first device to a reference point in a three-dimensional (3D) space;calculating by the first device a position of the first device in the 3D space based on inertial information captured by the first device;capturing images with a camera of the first device;identifying locations of one or more static features in the images;correcting the position of the first device based on the identified locations of the one or more static features; andpresenting a view of an interactive scene in a display of the first device, wherein operations of the method are executed by a processor.2. The method as recited in claim 1 , wherein calculating by the first device the position of the first device further includes:utilizing dead reckoning by estimating a current position of the first device based upon a previously determined position and advancing the previously determined position based upon a speed of the first device over elapsed time and course.3. The method as recited in claim 2 , wherein calculating the position is performed at predetermined intervals or after a predetermined number of inertial measurements.4. The method as recited in ...

Below grade waterproofing and methane barrier sheet membrane, with an aluminum protection layer and a method of making and using same

The invention is a below grade waterproofing and methane barrier sheet membrane with an aluminum facer and a method of making and using same, and more particularly the invention is directed to a dual layer system comprising of at least one bituminous moisture or waterproofing barrier sheet membrane with an aluminum facer or an aluminum layer that when combined is also a methane gas barrier, and is UV stable, that is used in construction of a building, and placed under, or around a foundation of a building or a dwelling or on its below grade retaining walls. Optionally, a liner and/or a drainage protection media can also be used with the inventive dual layer system.

MAINTAINING MULTIPLE VIEWS ON A SHARED STABLE VIRTUAL SPACE

Methods, apparatus, and computer programs for controlling a view of a virtual scene with a handheld device are presented. In one method, images of a real world scene are captured using a device. The method further includes operations for creating an augmented view for presentation on a display of the device by augmenting the images with virtual reality objects, and for detecting a hand in the images as extending into the real world scene. In addition, the method includes operations for showing the hand in the screen as detected in the images, and for generating interaction data, based on an interaction of the hand with a virtual reality object, when the hand makes virtual contact in the augmented view with the virtual reality object. The augmented view is updated based on the interaction data, which simulates on the screen that the hand is interacting with the virtual reality object. 1. A method comprising:capturing images of a real world scene using a handheld device;creating an augmented view for presentation on a display screen of the handheld device by augmenting the captured images with one or more virtual reality objects;detecting a user hand in the captured images as extending into the real world scene;showing the user hand in the display screen as detected in the captured images;generating interaction data based on an interaction of the user hand with a first virtual reality object from the one or more virtual reality objects when the user hand makes virtual contact in the augmented view with the first virtual reality object; andupdating the augmented view based on the interaction data, wherein the interaction data simulates on the display screen that the user hand is interacting with the first virtual reality object.2. The method as recited in claim 1 , wherein the interaction of the user hand is an action on the first virtual reality object selected from a group consisting of holding claim 1 , pushing claim 1 , pulling claim 1 , moving claim 1 , hitting ...

TRACKING POSITION OF DEVICE INSIDE-OUT FOR AUGMENTED REALITY INTERACTIVITY

Methods, systems, and computer programs are provided for generating an interactive space. One method includes identifying a reference point in a three-dimensional (3D) space using a portable device. The reference point is calibrated to an origin point of the portable device. The method includes determining by the device a position and an orientation of the portable device at the origin point. The position and orientation is determined using data from an inertial sensor of the portable device and data from the camera. The method includes generating by the portable device an augmented reality (AR) space using the reference point. The AR space includes virtual objects imposed over or in the 3D space. 1. A method , comprising:identifying a reference point in a three-dimensional (3D) space using a portable device, the reference point is calibrated to an origin point of the portable device;determining by the device a position and an orientation of the portable device at the origin point, the position and orientation is determined using data from an inertial sensor of the portable device and data from the camera; andgenerating by the portable device an augmented reality (AR) space using the reference point, wherein the AR space includes virtual objects imposed over the 3D space.2. The method of claim 1 , wherein the AR space has a second coordinate system that is referenced from a first coordinate system of the 3D space.3. The method of claim 1 , wherein the portable device uses a connection to a network to obtain data for the generating of the virtual objects of the AR space.4. The method of claim 1 , further comprising claim 1 ,tracking movement of the portable device in the 3D space, wherein movement of the portable device provides updates to a view presented into the AR space.5. The method of claim 4 , wherein the view presented into the AR space includes real-world objects in the 3D space and one or more of said virtual objects claim 4 , wherein said virtual objects ...

Modulator of the Cystic Fibrosis Transmembrane Conductance Regulator, Pharmaceutical Compositions, Methods of Treatment, and Process for Making the Modulator

Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

ACOUSTIC RECEIVERS WITH HINGED DIAPHRAGMS

Sound-producing acoustic receivers are disclosed. The acoustic receiver includes a housing, a first diaphragm, and a motor. The housing has an internal volume separated by the first diaphragm into a first front volume and a first back volume such that the first front volume has a first sound outlet. The first diaphragm includes a first paddle movable about a first hinge. The motor is disposed in the housing and includes an armature mechanically coupled to the first paddle. The first hinge is located between opposite ends of the first paddle such that actuation of the armature pivots both ends of the first paddle about the hinge. 1. A balanced armature receiver comprising:a housing having an internal volume;a first diaphragm separating the internal volume into a first front volume and a first back volume, the first front volume having a first sound outlet, the first diaphragm comprising a first paddle movable about a first hinge;a motor disposed in the housing, the motor including an armature mechanically coupled to the first paddle,the first hinge located between opposite ends of the first paddle such that actuation of the armature pivots both ends of the first paddle about the hinge.2. The receiver of claim 1 , the first hinge located closer to one end of the first paddle than the other end thereof claim 1 , wherein a majority of the first paddle moves in a direction opposite to force applied to the first paddle by the armature.3. The receiver of claim 2 , further comprising a second diaphragm defining a second front volume in the internal volume claim 2 , the second front volume having a second sound outlet claim 2 , the second diaphragm comprising a second paddle movable relative to a second hinge claim 2 , the armature mechanically coupled to the second paddle such that a majority of the second paddle moves in a same direction as force applied to the second paddle by the armature.4. The receiver of claim 3 , wherein the first hinge is a torsional hinge and the ...

REED FOR A RECEIVER AND METHOD OF METHOD OF MANUFACTURING THE SAME

An apparatus includes a first armature and a second armature, wherein the first armature and the second armature are coupled together in a common connection region; a coil, wherein at least a portion of the common connection region extends through the coil, the coil extending around a horizontal axis; one or more magnets; a drive rod coupled to the common connection region; and a diaphragm coupled to the drive rod; wherein electrical excitation of the coil causes the common connection region to move in a vertical direction orthogonal to the horizontal axis and not along the horizontal axis. 1. An apparatus comprising:a first armature and a second armature, wherein the first armature and the second armature are coupled together in a common connection region;a coil, wherein at least a portion of the common connection region extends through the coil, the coil extending around a horizontal axis;one or more magnets supported by a magnetically permeable support structure;a connector coupled to the common connection region; anda diaphragm coupled to the connector;wherein electrical excitation of the coil causes the common connection region to move in a vertical direction orthogonal to the horizontal axis and not along the horizontal axis.2. The apparatus of claim 1 , wherein the connector is s a drive rod.3. The apparatus of claim 1 , further comprising:an insulation layer disposed between the first armature and the second armature.4. The apparatus of claim 3 , wherein the insulation layer extends along the common connection region.5. The apparatus of claim 1 , wherein one or more of the first armature and the second armature includes bumps.6. The apparatus of claim 1 , wherein the one or more magnets comprise a material with a low magnetic permeability compared to the magnetically permeable support structure.7. The apparatus of claim 1 , wherein one or more of the first armature and the second armature comprise an iron/nickel compound.8. The apparatus of claim 1 , wherein ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1. A method for transmitting data between devices of an analyte monitoring system , the method comprising:generating sensor data using a sensor electronics module electrically connected to a continuous analyte sensor;establishing a two-way communication channel between the sensor electronics module and the a display device and each of the sensor electronics module and display device transmitting at a first transmission power; andinitiating a low power transmission mode responsive to sensing user input at user interface of the display device indicative of entering the mode, wherein the low power transmission mode comprises one or both of the sensor electronics module and the display device transmitting at a second transmission power that is lower than the first transmission power.2. The method of claim 1 , wherein the initiating comprises the display device sending a command to the sensor electronics module to enter the low power mode.3. The method of claim 1 , wherein the display device prompts a user to input a duration of time for the low power transmission mode claim 1 , and wherein the display device and the sensor electronics module automatically exit the low power transmission mode after expiration of the duration of time.4. The method of claim 1 , further ...

Systems and methods for processing and transmitting sensor data

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Air Filter Arrangement; Assembly; and, Methods

Air filter cartridges are disclosed. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described. 1. An air filter cartridge comprising: (i) the filter media pack being closed to passage of air therethrough, from the first flow face to the opposite second flow face, without filtering passage through the media;', '(ii) the first flow face being generally planar and perpendicular to a direction of extension of the media between the inlet and outlet flow faces; and,', '(iii) the media pack having a non-circular cross-sectional definition in a direction parallel to the first flow face; and,, '(a) a filter media pack having first and second, opposite, flow faces; the filter media pack comprising fluted media secured to facing media to define inlet and outlet flow channels extending between the first and second, opposite, flow faces;'} (i) the housing seal arrangement including a seal surface positioned for sealing engagement with a housing component in use;', '(ii) the seal surface extending completely around the media pack and including at least one pinch seal surface portion configured to sealingly engage a housing as it extends in a direction around the media pack, that also extends in a direction non-parallel to the first flow face; and,', (A) the pinch seal lip being positioned on, and molded integral with, the base; and,', '(B) the base and pinch seal lip defining a trough between at least a portion of the pinch seal lip and the media pack., '(iii) the housing seal arrangement comprises a base and the pinch seal lip;'}], '(b) a housing seal arrangement comprising a perimeter seal extending completely around the media pack;'}2. An air filter cartridge comprising: (i) the filter media pack being closed to passage of air therethrough, from the first flow face to the opposite second flow face, without filtering passage through the media; and,', '(ii) the first flow face being ...

Systems and methods for processing and transmitting sensor data

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Method and system for donating to third-party beneficiaries

The present invention relates to a network based, third-party beneficiary donation system, and in particular to systems and methods that allow a merchant to provide a choice to participating consumer(s) in the form of donations to third party beneficiaries based on consumer purchases wherein the consumer chooses their third party beneficiary from a merchant curated list or customer self-generated list and independently determines the percentage amount of the donation or selects a pre-determined amount. In this manner, consumers are provided with an option to purchase products from the authorized merchant knowing that the product purchases may result in a specified donation to a customer selected third-party beneficiary or multiple customer selected third party beneficiaries on a per product or per order basis. Third party beneficiaries are generally intended to be charities or causes but are not required to have tax-exempt status.

FILTER ARRANGEMENTS; HOUSINGS; ASSEMBLIES; AND, METHODS

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a seal thereon. 1. An air cleaner assembly comprising: (i) the inlet section comprising a precleaner arrangement including a plurality of dust separator tubes; and,', '(ii) the housing being openable for installation and removal of an internally received filter cartridge; and,, '(a) a housing including: an inlet section; a central section; and an outlet section;'} [ (A) an inlet flow end and an opposite outlet flow end; and,', '(B) media comprising a coiled arrangement including coils of fluted media secured to facing media and configured so that air entering the inlet flow end cannot exit the outlet flow end without filtering passage through the media;', '(C) the media pack having a non-circular perimeter;, '(i) a media pack having, '(ii) a housing seal arrangement including a seal portion removably sealed to the housing; and,', ["(A) the stationary portion under which a portion of a person's fingers can fit being closer to the inlet flow end of the media pack than to the outlet flow end of the media pack; and,", '(B) the first air filter cartridge including no preform portion at a location surrounded by coils of the media., "(iii) a preform arrangement secured to the media pack and including: a portion surrounding the media pack; and, a handle arrangement including a stationary portion under which a portion of a person's fingers can fit, between a portion of the handle arrangement and the media;"}], '(b) a first air filter cartridge removably positioned within the housing; the first air filter cartridge including2. An air cleaner assembly according to wherein:(a) the housing includes a side access cover thereon.3. An air cleaner assembly according to wherein:(a) the housing seal arrangement includes a radially directed housing seal portion.4. An air cleaner ...

METHOD FOR AN AUGMENTED REALITY CHARACTER TO MAINTAIN AND EXHIBIT AWARENESS OF AN OBSERVER

A method comprising: detecting a position of a portable device, the portable device including a camera that captures a real-world scene, and identifying an anchor within the real-world scene; generating an augmented reality scene formed by inserting a virtual character into the real-world scene, the virtual character configured to perform an action indicating awareness of the position or activity of the portable device; displaying the augmented reality scene on a display; wherein the action indicating awareness comprises adjusting a view direction, in the augmented reality scene, of the virtual character towards the portable device, and wherein the adjustment of the view direction of the virtual character changes a relationship of the view direction to the anchor, wherein the adjustment of the view direction of the virtual character includes adjustment of a head of the virtual character so as to look in the direction of the portable device. 1. A method for causing a virtual character to demonstrate awareness of a portable device's position or activity , the method comprising , detecting a position of a portable device , the portable device including a camera that captures a real-world scene , and identifying an anchor within the real-world scene , the anchor being tracked during movement of the portable device;generating an augmented reality scene formed by inserting a virtual character into the real-world scene as captured by the camera, the virtual character being positioned in the augmented reality scene in relation to the identified anchor, the virtual character configured to perform an action indicating awareness of the position or activity of the portable device;displaying the augmented reality scene on a display;wherein the action indicating awareness comprises adjusting a view direction, in the augmented reality scene, of the virtual character;wherein the adjustment of the view direction of the virtual character is in the direction of the position of the ...

AIR FITLER ARRANGEMENT; ASSEMBLY; AND, METHODS

An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and defining a media pack having opposite flow faces. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described. 1. An air filter cartridge comprising:(a) a filter media pack comprising fluted media secured to facing media and defining first and second, opposite, flow surfaces; and, (i) a pinch seal member configured to be pinched between seal flanges on a housing, when the air filter cartridge is installed for use; and,', '(ii) a trough provided between a portion of the pinch seal member and the filter media pack;, '(b) a housing seal arrangement; the housing seal arrangement being molded-in-place to a portion of the media and comprising(c) the filter media pack comprising a stacked construction of individual strips of media each comprising a fluted sheet and a facing sheet.2. An air filter cartridge according to wherein:(a) the filter media pack has a first set of two opposite sides;(b) a first side panel is positioned on a first side of the first set of the two opposite sides; and,(c) a second side panel is positioned on a second side of the first set of two opposite sides.3. An air filter cartridge according to wherein:(a) the first side panel is molded directly to the first side of the first set of two opposite sides; and,(b) the second side panel is molded directly to the second side of the first set of two opposite sides.4. An air filter cartridge according to wherein:(a) the housing seal arrangement extends around the media pack and the first and second side panels.5. An air filter cartridge according to wherein:(a) the filter media ...

Enhanced Human Capital Management System and Method

A system and method for human capital management. A set or sets of records corresponding to employees are encoded on a digital storage medium. Each record contains values for human capital management metrics. A user device accesses these records and presents on a display a dashboard management window. The dashboard management window contains at least one dashboard, which has at least one automatically-generated representation of the human capital metric values stored in the records encoded on the digital storage medium. The dashboards and their representations allow a user to effectively and efficiently manage human capital by easily viewing human capital metrics in a meaningful way. 1. A system for human capital management , comprising:a digital storage medium;an electronic device effective to receive input from a user and having a display;a plurality of employee records encoded on the storage medium, each one employee record being associated with an individual employee and containing a value for at least one human capital metric associated with the individual employee;said electronic device effective to access the plurality of employee records on the storage medium and present on the display a dashboard management window; andsaid dashboard management window having at least one dashboard window, each dashboard window containing at least one automatically-generated representation of the human capital metric values of a plurality of employee records.2. The system of wherein a custom dashboard window can be created by the user.3. The system of wherein said automatically-generated representation is a comparison of at least one human capital metric value from the record of a particular employee to the human capital metric values from a select plurality of employee records.4. The system of wherein said automatically-generated representation regards a key performance indicator metric.5. The system of wherein said key performance indicator metric is selected from the group ...

AIR FILTER ARRANGEMENT; ASSEMBLY; AND, METHODS

An air filter arrangement is disclosed. The air filter arrangement includes media comprising corrugated media secured to facing media and defining a media pack having opposite flow faces. Media pack arrangements including such media are described. Also described are filter cartridges including such media packs and air cleaners including the filter cartridges. Advantageous housing seal arrangements having a pinch seal member and forming a trough are described. Methods of assembly and use are also provided. Also, systems of use are described. 1. An air filter cartridge comprising: (i) the filter media pack includes filter media arranged between the first flow face and the second, opposite, flow face;', '(ii) the filter media pack having a rectangular cross-sectional shape, in a direction perpendicular to a central flow axis extending in an axial direction between the first flow face and the second, opposite, flow face; and', '(iii) the filter media pack comprising four sides extending between the first flow face and the second, opposite, flow face, wherein the four sides include a first pair of first and second opposite sides, and a second pair of first and second opposite sides;, '(a) a filter media pack having a first flow face and a second, opposite, flow face, wherein(b) end pieces over the first pair of first and second opposite sides of the filter media pack; and (i) an axial pinch seal portion configured to be pinched between seal flanges on a housing, when the air filter cartridge is installed for use;', '(ii) a trough located inwardly of the axial pinch seal portion, wherein the trough has an opening facing in the axial direction., '(c) a housing seal arrangement comprising a seal member molded in place on the air filter cartridge, wherein the housing seal arrangement comprises2. An air filter cartridge according to wherein:(a) the trough is configured to receive a portion of an air cleaner assembly projecting therein, during use.3. An air filter cartridge ...

Laminate Facing for Fiber Reinforced Materials and Composite Materials Formed Therefrom

The present invention provides a laminate material having a polyester film and a layer of polyester fibers cohesively bonded thereto. Generally, a metal layer deposited at least one surface of the laminate. The invention may also include a glass reinforced polymer layer formed on the laminated facer where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. The laminate may further include a second polymer layer having a thickness joined to the fiber layer and/or a layer of hot melt adhesive applied to the polyester fibers. Also presented is a composite material having a polyester film, a layer of polyester fibers bonded to the second polymer layer; a second polymer layer joined to the polyester film; and a glass reinforced polymer layer formed on the laminated facer, where the polymer of the glass reinforced polymer layer is commingled with the nonwoven of the laminated facer. 1. A laminate material comprising:a heat sealable polyester film having a thickness of 0.5-5 mil, anda layer of polyester fibers having a density of 17-100 GSM cohesively bonded directly thereto.2. The laminate of claim 1 , wherein the cohesive bond is selected from the group consisting of melt bonding claim 1 , point bonding and roll bonding claim 1 , with the use of a powdered binder on the fibers.3. The laminate of claim 1 , wherein the cohesive bond is selected from the group consisting of melt bonding claim 1 , point bonding and roll bonding claim 1 , without the use of a secondary binder.4. The laminate of claim 1 , further comprising:a metal layer deposited on at least one surface of the laminate.5. The laminate of claim 1 , wherein the polyester film has a thickness of 0.5-3.0 MIL.6. The laminate of claim 1 , wherein the polyester film has a thickness of 0.5-3.0 MIL and the nonwoven has a density of 30-65 GSM.7. The laminate of claim 1 , wherein the polyester film has a thickness of 0.5-1.5 MIL and the nonwoven has a density of 17- ...

MAINTAINING MULTIPLE VIEWS ON A SHARED STABLE VIRTUAL SPACE

Methods, apparatus, and computer programs for controlling a view of a virtual scene with a handheld device are presented. In one method, images of a real world scene are captured using a device. The method further includes operations for creating an augmented view for presentation on a display of the device by augmenting the images with virtual reality objects, and for detecting a hand in the images as extending into the real world scene. In addition, the method includes operations for showing the hand in the screen as detected in the images, and for generating interaction data, based on an interaction of the hand with a virtual reality object, when the hand makes virtual contact in the augmented view with the virtual reality object. The augmented view is updated based on the interaction data, which simulates on the screen that the hand is interacting with the virtual reality object. 1. A method , comprising:receiving, by a head-mounted display (HMD), remote images of a remote real world scene sent by a remote device, the HMD being worn by a user and the remote device being operated by a remote user;capturing local images of a local real world scene using the HMD;processing, by the HMD, an augmented view for presentation on a display screen of the HMD by combining the remote images with the captured local images and one or more virtual reality objects, wherein the augmented view simulates that the user and the remote user share a space that includes the one or more virtual reality objects;detecting an interaction of a hand with a first virtual reality object from the one or more virtual reality objects when the hand makes virtual contact in the augmented view with the first virtual reality object; andupdating the augmented view to the HMD based on the interaction of the hand with the first virtual reality object to simulate that the hand is touching or moving the first virtual reality object.2. The method as recited in claim 1 , further including:transmitting, from ...

Method for Payment

A method, for trade between a buyer and a seller using a sales server of the seller and a terminal device of the buyer, for allowing a payment in accordance with a transaction data record from the buyer to the seller, wherein a) the payment request is provided by the sales server for a terminal service server, and b) the terminal service server uses the transaction data record for the terminal device to produce a one-time terminal. The payment is prompted, wherein c) the one-time terminal is transmitted, d) the one-time terminal is put into contact with a payment transaction security element, e) the payment information is extracted in cryptographically protected form and transferred to the one-time terminal, f) the transferred payment information is transmitted to the terminal service server or to the sales server, and g) the transmitted payment information is used to prompt the payment. 113-. (canceled)14. A method for enabling , in trade between a buyer and a seller by means of a sale server of the seller and an end device of the buyer , a payment from the buyer to the seller in accordance with a transaction data set , outputting a payment request comprising the transaction data set by the sale server; and', 'initiating the payment in accordance with the transaction data set by making available a payment information item;, 'wherein upon payment, the method comprisingwherein in the method further comprises:a) making the payment request available by the sale server to a terminal service server; andb) making on the terminal service server a one-time terminal available on the end device generated by using the transaction data set for the end device, wherein the one-time terminal is configured such that,as soon as it is made available on the end device, it is connectible on the end device to a payment transaction security element containing the payment information, such that the payment information is extracted in cryptographically secured form from the payment ...

FLUID-FILLED EAR TIP

An ear tip includes a body member that forms an internal chamber. The body member has an exterior portion configured to contact at least a portion of an ear canal of a user of the ear tip. The internal chamber has a nominal volume when the internal chamber is not deformed. A fluid is disposed in the internal chamber of the body member where a volume of the fluid-filled internal chamber is less than the nominal volume when the fluid-filled internal chamber is deformed. 1. An ear tip comprising:a body member forming an internal chamber,the body member having an exterior portion configured to contact at least a portion of an ear of a user of the ear tip, the internal chamber having a nominal volume when the internal chamber is not deformed; anda fluid disposed in the internal chamber of the body member,a volume of the fluid-filled internal chamber is less than the nominal volume, wherein the fluid-filled internal chamber is deformed.2. The ear tip of is for coupling to a sound emitting device claim 1 , the ear tip further comprising a sound passage through the body member claim 1 , the sound passage having a sound inlet and a sound outlet.3. The ear tip of claim 2 , wherein the volume of the fluid-filled internal chamber is 40 percent to 90 percent of the nominal volume.4. The ear tip of claim 2 , wherein the volume of the fluid-filled internal chamber is 60 percent to 70 percent of the nominal volume.5. The ear tip of claim 2 , wherein the fluid has a viscosity of 1 centipoise to 10 claim 2 ,000 claim 2 ,000 centipoise.6. The ear tip of claim 2 , wherein the fluid is a viscous non-Newtonian fluid.7. The ear tip of claim 2 , wherein a distance between an exterior surface of the body member and an interior surface of the body member defines a wall thickness of the body member claim 2 , the body member including a first wall portion having a first thickness and a second wall portion having a second thickness less than the first thickness claim 2 , wherein the exterior ...

AUDIO DEVICE WITH ACOUSTIC VALVE

A hearing device such as a hearing aid, ear pod, headphone, or other wearable is provided, whose components include the following: an acoustic transducer with a vent port operable to produce sound, a housing of the acoustic transducer with a sound opening, and an actuatable acoustic valve disposed in the housing, where the acoustic valve is actuatable to alter passage of sound through the acoustic vent to change the state of the hearing device between an open vent state and a closed vent state, so that actuation of the valve changes an acoustic characteristic of the hearing device. 1. A hearing device comprising:a housing having a sound opening;a sound-producing electroacoustic transducer disposed within the housing, the transducer including a diaphragm separating an internal volume of the housing into a back volume and a front volume, the front volume including a sound port;a vent port acoustically coupled to the internal volume;the front volume acoustically coupled to the sound opening of the housing, a portion of the housing configured to be disposed at least partially in a user's ear, wherein sound produced by the transducer emanates from the sound port of the front volume and through the sound opening of the housing;an acoustic valve disposed in the housing, the valve having a first port acoustically coupled to the internal volume via the vent port, and the valve acoustically coupled to a volume external to the internal volume,the valve actuatable between an open state and a closed state, wherein actuation of the valve changes an acoustic characteristic of the hearing device.2. The hearing device of claim 1 , wherein acoustic impedance between the internal volume and the volume external to the internal volume is greater when the valve is in the closed state than when the valve is in the open state.3. The hearing device of claim 1 , wherein the actuation of the valve changes an acoustic output of the hearing device.4. The hearing device of claim 1 , wherein the ...

ANTI-FIBROTIC COMPOUNDS

Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. 5. The compound of or , or a pharmaceutically acceptable salt thereof , whereinX is O or a bond;Y is O or a bond;Z is O or a bond;{'sup': 1', '2', '1', '2', '8, 'Rand Rare independently hydrogen, alkyl, alkynyl, cycloalkylalkyl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl, wherein Rand Rare each optionally substituted with 1 or 2 independent substituents R;'}{'sup': 1', '2, 'or Rand Rtogether with the atoms to which they are attached form a heterocyclyl ring;'}{'sup': 3', '3', '8, 'Ris hydrogen, alkyl, alkynyl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl, wherein Ris optionally substituted with 1 or 2 independent substituents R;'}{'sup': 6', 'c, 'sub': '2', 'each occurrence of Ris, independently, halogen, cyano, alkyl, heteroaryl, heterocyclyl, or —S(O)R;'}m is 1 or 2;{'sup': 8', 'a', 'b, 'each occurrence of Ris, independently, alkyl or NRR; and'}{'sup': a', 'b', 'c, 'each occurrence of R, R, and Ris, independently, hydrogen, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and heterocyclyl.'}8. The compound of or , or a pharmaceutically acceptable salt thereof , whereinX is O or a bond;Y is O or a bond; provided that at least one of X and Y is O;{'sup': 1', '2, 'Rand Rare independently, alkyl, alkynyl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl, wherein said heteroarylalkyl, heterocyclyl, and heterocyclylalkyl are optionally substituted with 1 or 2 independent alkyl groups;'}{'sup': 6', 'c, 'sub': '2', 'each occurrence of Ris, independently, halogen, cyano, alkyl, heteroaryl, heterocyclyl, or —S(O)R;'}m is 1 or 2 ...

AUDIO DEVICE WITH CONTEXTUALLY ACTUATED VALVE

The present disclosure pertains to hearing devices configurable between open fit and closed fit configurations at different times through actuation of one or more acoustic valves located in one or more corresponding sound passages of the hearing device. The one or more acoustic valves of the hearing device are adaptively controlled based on context detected by one or more sensors. The context may be, but is not limited to, a mode of operation of the hearing devices which may include, for example, an audio content playback mode and a voice communication mode. The actuatable valves may be actuatable in situ without having to remove the hearing device from the user's ear thereby enabling the user to experience the benefit of a closed fit or an open fit depending on the user's desire or other context. 1. A hearing device comprising:a first housing having a first contact portion configured to form a substantially sealed coupling with a user's ear, the first housing having a first sound opening;a sound-producing electro-acoustic first transducer disposed in the first housing, the first transducer configured to generate an acoustic signal in response to an electrical excitation signal applied thereto, wherein an acoustic signal generated by the first transducer emanates into the user's ear via the first sound opening when the first contact portion of the first housing is coupled to the user's ear;a first acoustic valve disposed along a first acoustic passage of the first housing, the first acoustic valve actuatable to alter passage of sound through the first acoustic passage;an electrical circuit configured to adaptively actuate the acoustic valve based on context detected by a sensor.2. The device of further comprising a wireless communication interface claim 1 , wherein the electrical circuit is configured to actuate the first acoustic valve based on a signal received via the wireless communication interface claim 1 , the signal indicative of the context detected by the ...

AUDIO DEVICE WITH AUDIO SIGNAL PROCESSING BASED ON ACOUSTIC VALVE STATE

Methods and apparatus change operation of a hearing device based on a state of an acoustic valve in the hearing device. In some examples an electrical circuit performs one or more of differing operations depending on a state of the acoustic valve. Some operations change the signal to a sound producing transducer and other operations change other operations of the hearing device. For example, an electrical circuit changes active noise cancelling operation, changes equalization settings, provides noise reduction improvements, provides beam forming changes and other operations based on a state of the acoustic valve. In some implementations, a change in acoustic valve state is used to change the operation of the hearing device. 1. A hearing device comprising:a housing having a contact portion configured to form a substantially sealed coupling with a user's ear, the housing having a sound opening;a sound-producing electroacoustic transducer disposed in the housing, the sound producing transducer configured to generate an acoustic signal in response to an electrical excitation signal applied thereto, wherein an acoustic signal generated by the sound producing transducer emanates into the user's ear via the sound opening when the portion of the housing is coupled to the user's ear;an acoustic valve disposed in an acoustic passage of the housing, the acoustic valve actuatable between two or more states by the electrical circuit to alter passage of sound through the acoustic passage; andan electrical circuit configured to control operation of the hearing device based on a state of the acoustic valve.2. The hearing device of claim 1 , the electrical circuit includes a processor claim 1 , wherein the processor is configured to control operation by adapting the electrical excitation signal applied to the sound producing transducer based on the state of the acoustic valve.3. The hearing device of claim 1 , wherein the electrical circuit is operative to equalize the acoustic ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 112-. (canceled)13. A system for monitoring analyte concentration data of a host , comprising:a continuous analyte sensor;an analyte sensor system comprising a near field communication (NFC) transceiver and a sensor electronics module configured to electrically couple to the continuous analyte sensor; wherein the analyte sensor system is configured to generate analyte sensor data using the continuous analyte sensor; anda communication device comprising a NFC initiator and configured to transmit a communication signal to the analyte sensor system, wherein the communication signal includes sensor calibration information, and whereinthe analyte sensor system is configured to receive the sensor calibration information via the NFC transceiver and use the information to calibrate analyte sensor data.14. The system of claim 13 , wherein the communication device is configured to initiate the transmission of the communication signal responsive to receiving user input indicative of starting the transmission of the communication signal.15. The system of claim 13 , wherein the analyte sensor system is configured to establish one or more communication links with one or more display devices using Bluetooth wireless protocol.16. The system of claim 15 , wherein the analyte sensor ...

SEAL ARRANGEMENT FOR FILTER ELEMENT; FILTER ELEMENT ASSEMBLY; AND, METHODS

A filter cartridge arrangement is provided which includes a media pack comprising Z-filter media, a preform and a housing seal member. Improvements in the preform and seal member are described which include: a single beveled surface of the seal member to facilitate installation; and, an inside region of the seal member having a tip adjacent in inwardly directed lip of the preform, to control flash during molding. A variety of media pack configurations and features are described. 119-. (canceled)20. A filter element comprising: '(i) a plurality of flutes extending in an axial direction from the first flow face to the second flow face;', '(a) a media pack including a first flow face and an opposite second flow face, an axial direction extending from the first flow face to the second flow face, and a periphery extending between the first flow face and the second flow face; the media pack defining (i) the housing seal support section extends axially away from the first flow face in a direction away from the media pack;', '(ii) the housing seal support section includes a radially outwardly facing surface and a radially inwardly facing surface; and', '(ii) the media face cross-piece arrangement extends across the first flow face;, '(b) a first end piece comprising a housing seal support section, and a media face cross-piece arrangement, wherein (i) a first portion sealing an interface between the first end piece and the media pack, and extending from the first flow face toward the second flow face over the periphery of the media pack;', '(ii) a second portion oriented to form an air cleaner seal, between the filter element and an air cleaner, in use;', '(iii) the second portion being located along the radially outwardly facing surface of the housing seal support section; and', '(iii) the first and second portions of the overmold being integral with one another; and, '(c) an overmold formed of a sealing material having (i) the second end piece is spaced from the first end ...

Acclimatization therapy for first time cpap and niv users

A method of acclimatizing a user to provide continuous positive airway pressure (CPAP) therapy, including operating a device for treating sleep disordered breathing (SDB) during successive treatment sessions, wherein the device provides continuous positive airway pressure during sleep, includes determining a clinically-derived full therapeutic pressure, applying a sub-therapeutic treatment pressure for the duration of a first session, obtaining responses to a series of pre-programmed patient and/or bed partner feedback questions before the start of a second session, and, based on the responses, either incrementally increasing the treatment pressure for the second session if the responses indicate that the patient is adjusting to therapy, or maintaining the treatment pressure for the second session if the responses do not indicate that the patient is adjusting to therapy.

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

Provided herein are compounds that inhibit pKal, a serine protease whose activity is responsible for proteolytically cleaving kininogen and generating the potent vasodilator and pro-inflammatory peptide bradykinin, which can lead to painful and debilitating inflammatory attacks (e.g., edema). Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating pKal-related diseases and disorders (e.g., edema) with the compounds in a subject, by administering the compounds and/or compositions described herein. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:A is substituted or unsubstituted heteroarylene.3. (canceled)4. (canceled)5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 'A', 'each occurrence of Ris, independently, hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, a nitrogen protecting group when attached to a nitrogen atom, or an oxygen protecting group when attached to an oxygen atom.'}6. (canceled)7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '1', 'sub': '2', 'Ris —NH.'}8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 2', 'A', 'A, 'sub': '2', 'Ris substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted alkyl, —OR, or —N(R).'}9. (canceled)10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '2', 'Ris substituted or unsubstituted heteroaryl.'}11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': '2', 'Ris substituted or unsubstituted fused bicyclic heteroaryl.'}12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein:{'sup': 3', '3', 'A', 'A, 'sub': '2', 'Ris substituted or unsubstituted alkyl, substituted or ...

Universal Potato Chip Cooker

Potato chip cooking process and apparatus includes controlled cooking of potato slices from the initial to the final cooking stages. Slices are deposited in hot cooking oil to develop a slice pack which is carried along a cooking path during which the pack is agitated and mixed by paddle means or tumbled so that the individual slices receive maximum contact with the cooking medium. The cooking path may be divided into one or more stages in each of which the cooking times and temperatures are selected and maintained to produce potato chips of different styles having a final moisture content in the range of 1.2% to 2%. The apparatus includes temperature and oil circulation controls for the oil heat exchangers dedicated to each stage of a cooking protocol. A multiplicity of variable rate, rotatable paddle wheel assemblies are positioned along the cooking path for thorough agitation of the potato pack encouraging good oil contact with the individual slices and consistent, chip-to-chip final moisture content.

Fairlead Latch Device

A self-aligning fairlead latch device is provided for guiding and securing an anchor chain between an offshore structure and an anchor. The fairlead latch device includes a latch housing pivotally mounted to a fairlead housing. The latch housing includes one or more latches for securing the anchor chain in place. The fairlead latch device further includes an upper retainer component that is coupled to an upper support structure and a lower support structure. The coupling of the upper retainer component to the support structures allow the fairlead latch device to be relocated by lifting of the device from the support structures. 1. A fairlead latch device for guiding and securing an anchor chain , the fairlead latch device comprising:a fairlead housing pivotally coupled to an offshore structure, wherein the fairlead housing comprises an upper support structure and a lower support structure each attached to the offshore vessel, the upper and lower support structures configured to provide the pivotal coupling;an upper retainer component configured to engage and disengage from the upper support structure;the fairlead housing including a lower support structure engagement member configured to engage and disengage from the lower support structure, whereby allowing the fairlead housing to be removable from the upper and lower support structures by disengaging the upper retainer component from the upper support structure;wherein the fairlead housing is configured to receive and guide an anchor chain during deployment or retrieval of the anchor chain between the vessel and an anchor;a latch housing pivotally mounted to the fairlead housing, wherein the latch housing extends away from the fairlead housing;a latch mechanism mounted to the latch housing, wherein the latch device includes a ratchet assembly; andan actuator for operating the ratchet assembly.2. The fairlead latch device according to claim 1 , wherein the fairlead housing is configured to guide an anchor chain ...

FILTER ARRANGEMENTS; HOUSINGS; ASSEMBLIES; AND, METHODS

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is permanently mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a radial seal thereon. 1. An air filter cartridge arrangement removeably installable in an air cleaner housing during use; the air filter cartridge arrangement comprising: (i) an inlet flow end and an opposite outlet flow end;', '(ii) a plurality of inlet flow flutes open at the inlet flow end and closed to passage of air therefrom adjacent the outlet flow end;', '(iii) a plurality of outlet flow flutes closed adjacent the inlet flow end and open to outlet flow at the outlet flow end; and,', '(iv) a non-circular cross-sectional shape comprising an oval shape with two, opposite, straight sides and two, opposite, curved ends; and,, '(a) a media pack having(b) a member surrounding the media pack including at least two, spaced, radially outwardly projecting ribs thereon; and,(c) a housing seal arrangement secured to an end of the media pack and including a radially outwardly directed seal member.2. An air cleaner assembly comprising: (i) the central main filter cartridge arrangement receiving section having a side access cover thereon positioned to open a service access at a location for service access to an interior of the central main cartridge arrangement receiving section; and,', '(ii) the access cover including an interior surface with an outwardly projecting cartridge handle recess therein;, '(a) a housing including: an inlet section; an opposite outlet section; and, a central main filter cartridge arrangement receiving section between the inlet section and outlet section;'} [ (A) an oval cross-sectional shape; and,', '(B) a housing seal arrangement secured to the media pack; the housing seal arrangement comprising a seal member having a radially directed seal surface surrounding a framework; and, '(i) the media pack having, '(ii) a handle member ...

TURBOMACHINE HAVING A MOUNTING ELEMENT

A to turbomachine () is provided, having a first component () and a second component () which are assembled together in an arrangement relative to each other in the turbomachine (), and further having a mounting element () which at least stabilizes the first component () and a second component () in their relative arrangement. The mounting element () is either in the form of a bimetallic element or contains a shape memory alloy. 1. A turbomachine comprising:a first component and a second component assembled together in an arrangement relative to each other in the turbomachine;a mounting element at least stabilizing the first component and a second component in the relative arrangement;the mounting element being a bimetallic element.2. The turbomachine as recited in wherein the bimetallic element is provided such that the bimetallic element increasingly stabilizes the first and second components in the relative arrangement as the temperature increases.3. The turbomachine as recited in wherein the bimetallic element includes at least two contiguous layers made of different materials claim 1 , at least one of the layers having a varying thickness over its planar extent.4. A turbomachine comprising:a first component and a second component assembled together in an arrangement relative to each other in the turbomachine;a mounting element at least stabilizing the first component and a second component in the relative arrangement,the mounting element containing a shape memory alloy.5. The turbomachine as recited in wherein the mounting element is at least partially manufactured through additive manufacturing.6. The turbomachine as recited in wherein the mounting element and the first component are fixedly connected to one another.7. The turbomachine as recited in wherein the mounting element and the first component are connected to one another by a material-to-material bond.8. The turbomachine as recited in wherein the first component is a fluid line.9. The turbomachine as ...

DIESEL EXHAUST FLUID FORMULATION THAT REDUCES UREA DEPOSITS IN EXHAUST SYSTEMS

A Diesel Exhaust Fluid (DEF) that includes urea, demineralized water and between 5 and 300 ppm formaldehyde, this formulation of DEF include less than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium, and potassium, the formulation also includes less than 0.3 ppm copper, zinc, chromium, and nickel. This formulation of DEF reduces the accumulation of urea deposit in the diesel exhaust system relative to other formulation of specification grade DEF that include less formaldehyde. 1. A formulation for reducing oxides of nitrogen in diesel engine exhaust , comprising:about 19.0 wt. % to about 40 wt. % urea;at least 0.0010 wt. % formaldehyde; anddemineralized water.2. The formulation according to claim 1 , including:no more than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium and potassium; andno more than 0.3 ppm copper, zinc, chromium, and nickel.3. The formulation according to claim 2 , comprising:between about 0.001 wt. % and about 0.01 wt. % formaldehyde.4. The formulation according to claim 2 , further including:between about 15.0 wt. % to about 40.0 wt. % ammonium carbamate.5. The formulation according to claim 4 , comprising:between about 19.0 wt. % to about 35.0 wt. % urea;between about 15.0 wt. % to about 40.0 wt. % ammonium carbamate;at least 0.0010 wt. % formaldehyde;between about 40.0 wt. % to about 60.0 wt. % demineralized water;no more than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium and potassium; andno more than 0.3 ppm copper, zinc, chromium, and nickel.6. The formulation according to claim 5 , wherein said formulation comprises:between about 19.0 wt. % to about 35.0 wt. % urea;between about 20.0 wt. % to about 35.0 wt. % ammonium carbamate;between about 0.0020 wt. % to about 0.01 wt. % formaldehyde;between about 45.0 wt. % to about wt. 55.0% demineralized water.7. The formulation according to claim 5 , wherein said formulation comprises:between about 19.0 wt. % to about 22.0 wt. % urea;between ...

DIESEL EXHAUST FLUID FORMULATION THAT REDUCES UREA DEPOSITS IN EXHAUST SYSTEMS

A Diesel Exhaust Fluid (DEF) that includes urea, demineralized water and between 5 and 300 ppm formaldehyde, acetaldehyde, propianaldehyde, or butyraldehyde, and this formulation of DEF include less than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium, and potassium, the formulation also includes less than 0.3 ppm copper, zinc, chromium, and nickel. This formulation of DEF reduces the accumulation of urea deposit in the diesel exhaust system relative to other formulation of specification grade DEF that include less formaldehyde. 1. A formulation for reducing oxides of nitrogen in diesel engine exhaust , comprising:about 19.0 wt. % to about 40 wt. % urea;at least 0.2 added wt. % of an aldehyde selected from the group consisting of: formaldehyde, acetaldehyde, propianaldehyde, and butyraldehyde; anddemineralized water.2. The formulation according to claim 1 , wherein the aldehyde is formaldehyde.3. The formulation according to claim 1 , including:no more than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium and potassium; andno more than 0.3 ppm copper, zinc, chromium, and nickel.4. The formulation according to claim 3 , comprising:between about 0.2 added wt. % and about 0.4 added wt. % of an aldehyde selected from the group consisting of: formaldehyde, acetaldehyde, propianaldehyde, and butyraldehyde.5. The formulation according to claim 3 , further including:between about 15.0 wt. % to about 40.0 wt. % ammonium carbamate.6. The formulation according to claim 5 , comprising:between about 19.0 wt. % to about 35.0 wt. % urea;between about 15.0 wt. % to about 40.0 wt. % ammonium carbamate;at least 0.2 added wt. % of an aldehyde selected from the group consisting of:formaldehyde, acetaldehyde, propianaldehyde, and butyraldehyde;between about 40.0 wt. % to about 60.0 wt. % demineralized water;no more than no more than 0.6 ppm of phosphates, calcium, iron, aluminum, magnesium, sodium and potassium; andno more than 0.3 ppm copper, zinc, ...

AIR FILTER ARRANGEMENT; ASSEMBLY; AND, METHODS

An air filter arrangement is disclosed. The air filter arrangement includes strips of media comprising fluted sheets secured to facing sheets and forming inlet and outlet flutes secured to one another in a stack. Media pack arrangements including such stacked media with peripheral, perimeter, housing seal arrangements are described. Also described are air cleaners including the filter cartridges. Methods of assembly and use are also provided. Also, systems of use are described. 1. An air filter cartridge comprising: (i) the filter media pack being closed to passage of air therethrough, from the first flow face to the opposite second flow face, without filtering passage through the media; and,', '(ii) the first flow face being generally planar and perpendicular to a direction of extension of the media between the inlet and outlet flow faces;, '(a) a filter media pack having first and second, opposite, flow faces; the filter media pack comprising fluted media secured to facing media to define inlet and outlet flow channels extending between the first and second, opposite, flow faces;'} (i) the housing seal arrangement comprising a pinch seal lip having a seal surface positioned for sealing engagement with a housing component in use; the seal surface facing, generally, in an opposite direction from the first flow face and, generally, in the same direction as the second flow face;', '(ii) the seal surface extending completely around the media pack and including at least one seal surface portion, as it extends in a direction around the media pack, that is non-parallel to the first flow face., '(b) a housing seal arrangement comprising a perimeter seal extending completely around the media pack'}2. An air filter cartridge according to wherein:(a) at least a portion of the first seal surface of the pinch seal lip, that extends in a direction non-parallel to the first flow face, extends at an angle of at least 2° relative to the first flow face.3. An air filter cartridge ...

System and Method for Controlling Wheel Brakes on a Trailer in a Tractor-Trailer

A system and method for controlling wheel brakes on a trailer in a tractor-trailer are provided. Upon receiving a command to apply a trailer wheel brake, the system determines a speed of the tractor-trailer responsive to a speed signal generated by a vehicle speed sensor. The system also estimates a threshold speed based on a level of friction between the tractor-trailer and a road surface on which the tractor-trailer is travelling. The system then generates a control signal to control delivery of fluid pressure to the trailer wheel brake. The control signal causes delivery of a first fluid pressure to the trailer wheel brake when the speed meets a predetermined condition relative to the threshold speed and a second fluid pressure, less than the first fluid pressure, when the speed does not meet the predetermined condition.

Retractable Auger Head

A retractable auger boring cutter head. The cutter head has fixed cutters and at least one pivoting cutter. The pivoting cutter is biased to a position that extends beyond a diameter of a casing being installed. When pulled back through the casing, a surface of the pivoting cutter contacts the casing, reducing the effective diameter of the cutter head and allowing it to be removed.

FILTER ARRANGEMENTS; HOUSINGS; ASSEMBLIES; AND, METHODS

Air cleaner and preferred components for an air cleaner are provided. In certain arrangements, a band is mounted to the media pack, surrounding the media. Also, the cartridge is non-circular and includes a seal thereon. 119-. (canceled)20. An air filter cartridge comprising: (i) an inlet flow end and an opposite outlet flow end; and', '(ii) filter media extending between the inlet flow end and the opposite outlet flow end; and, '(a) a filter media pack having '(i) the housing seal arrangement comprising a seal member mounted on a frame portion; and,', '(b) a radially outwardly directed housing seal arrangement secured to an end of the media pack;'} (i) the band located at an end of the media pack remote from the housing seal arrangement and having a first end, a second end, and two opposite sides extending between the first end and the second end;', '(ii) the band having a ramp-engagable end portion for selective engagement with a housing ramp during installation of the filter cartridge into a housing;', '(iii) the ramp-engageable end portion of the band having an end grid extending thereacross; the end grid extending across an end of the media pack remote from the end at which the radially directed housing seal arrangement is located; and', '(A) the projection arrangement on the band comprising a handle and, having a recess region provided between a portion of the handle and the media pack;', '(iv) the band having a projection arrangement to provide for grasping of the band during handling; the projection arrangement being in overlap with one of the band first end and the band second end and not in overlap with the other of the band first end and the band second end, and not in overlap with the two opposite band sides;'}, '(v) the band being spaced from, and separate from, the frame portion of the housing seal arrangement., '(c) a band defining an interior and having the media pack positioned therein and permanently mounted thereto;'}21. An air filter cartridge ...

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 120-. (canceled)21. A transcutaneous glucose sensor system , the system comprising:a transcutaneous glucose sensor comprising an in vivo portion, wherein the transcutaneous sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, wherein the at least one electrode is a working electrode;a sensor electronics unit operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics unit comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor; anda display device operatively connected to the sensor electronics unit, wherein the display device is configured to display a glucose value. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/546,099, filed Aug. 20, 2019, which is a continuation of U.S. application Ser. No. 15/413,206, filed Jan. 23, 2017, now abandoned, which is a continuation of U.S. application Ser. No. 13/830,330, filed Mar. 14, 2013, now U.S. Pat. No. 9,788,354, which is a continuation of U.S. application Ser. No. 13/827,577, filed Mar. ...

Nanostructural designs for electrode materials of fluoride ion batteries

The present disclosure relates to a fluoride shuttle battery and nanostructures of copper based cathode materials in the fluoride shuttle battery. The F-shuttle batteries of present disclosure comprise a liquid electrolyte, which allows the F-shuttle batteries to operate under room temperature. The minimum thickness of copper layer within the copper nanostructures is no more than 20 nm. The thickness of copper layer within the copper nanostructures is controlled and reduced to ensure the energy densities of F-shuttle batteries.

SYSTEMS AND METHODS FOR PROCESSING AND TRANSMITTING SENSOR DATA

Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device. 1. A method for detecting sleep current in a sensor device using a sleep current circuit in communication with the sensor device , the method comprising:initiating a reduced power state for the sensor device;providing a sleep pulse signal to a capacitor in the sleep current circuit;measuring a charge on the capacitor in the sleep current circuit; andcomparing the charge on the capacitor to a predetermined threshold to determine if the charge on the capacitor exceeds the predetermined threshold.2. The method of claim 1 , further comprising terminating the reduced power state for the sensor device.3. The method of claim 2 , wherein the measuring a charge on the capacitor is performed after the reduced power state is terminated.4. The method of claim 1 , further comprising terminating the sleep pulse signal while the sensor device is in a reduced power state.5. The method of claim 1 , wherein the predetermined threshold is an expected charge on the capacitor that correlates with the sleep pulse signal.6. The method of claim 1 , wherein the sleep current is unexpected current flowing within the sensor device while it is in the reduced power state claim 1 , and wherein the sleep current is detected by subtracting the predetermined threshold from the charge on the capacitor. ...