СИСТЕМА ДЛЯ ОТБОРА СЕЛЬСКОХОЗЯЙСТВЕННЫХ ПРОБ И СООТВЕТСТВУЮЩИЕ СПОСОБЫ

Автоматизированная система отбора проб, управляемая компьютером, и соответствующие способы сбора, обработки и анализа сельскохозяйственных проб на наличие различных химических свойств, таких как доступных растениям питательных веществ. Система отбора проб позволяет обрабатывать и анализировать множество проб на различные аналиты или химические свойства в одновременно параллельном или частично параллельном режиме. Предпочтительно, система может обрабатывать пробы почвы «по мере сбора» без сушки и измельчения. Система включает в себя подсистему подготовки проб, которая принимает пробы почвы, собранные подсистемой сбора проб, и производит суспензию (например, смесь почвы, растительности и/или органических удобрений и воды) и подсистему химического анализа, которая обрабатывает подготовленные пробы суспензии для количественной оценки нескольких аналитов и/или химических свойств пробы. Система подготовки может содержать контур рециркуляции суспензии, связанный с устройствами, предназначенными ...

Зонд растворения для растворения поляризованного материала образца

Изобретение относится к оборудованию для растворения поляризованного материала образца, а именно динамической поляризации ядер. Зонд растворения содержит удлиненный трубчатый внешний кожух, первый и второй удлиненные трубопроводы и сужающий элемент. Внешний кожух имеет открытые противоположные первый и второй концы и внутреннюю поверхность, ограничивающую удлиненную полость, проходящую в проточном сообщении между первым и вторым концами. Первый удлиненный трубопровод имеет противоположные первый и второй открытые концы и удлиненный путь потока, проходящий в проточном сообщении между ними. Второй удлиненный трубопровод имеет противоположные первый и второй открытые концы и удлиненный путь выведения, проходящий в проточном сообщении между ними. Сужающий элемент имеет противоположные первый и второй концы. Причем указанный первый конец сужающего элемента проходит в указанный первый открытый конец первого удлиненного трубопровода. Обеспечивается эффективное растворение твердого поляризационного ...

Унифицированный парогенератор

Изобретение относится к области спектрометрии подвижности ионов. Парогенератор для устройства обнаружения, содержащий: источник пара, присоединенный посредством проточного канала и предназначенный для подачи пара через средство блокировки к выпускному отверстию для подачи пара в устройство обнаружения, причем средство блокировки содержит первый паропроницаемый канал, выполненный с возможностью препятствования диффузии пара от источника к выпускному отверстию и с обеспечением возможности принудительного перемещения пара от источника к выпускному отверстию, и приемник, отделенный от выпускного отверстия первым паропроницаемым каналом, причем приемник содержит материал, выполненный с возможностью поглощения пара, и выполнен с возможностью перенаправления диффузии пара от выпускного отверстия, причем первый паропроницаемый канал и приемник расположены таким образом, что в результате приложения разности давлений между выпускным отверстием и источником пара сопротивление принудительному прохождению ...

СПОСОБ И СИСТЕМА ДЛЯ ОБНАРУЖЕНИЯ ТВЕРДЫХ ЧАСТИЦ В ОТРАБОТАВШИХ ГАЗАХ

Предложены способы и системы для датчика твердых частиц (ТЧ) в сборе, расположенного ниже по потоку от дизельного фильтра твердых частиц в выпускной системе двигателя внутреннего сгорания. В одном примере датчик ТЧ в сборе может содержать изогнутую трубку с первым, верхним по потоку, концом, соединенным с выпускным каналом, и вторым, расходящимся раструбом наружу, концом на нижнем по потоку конце датчика. Таким образом, второй конец изогнутой трубки может образовывать устройство Вентури, служащее для блокирования попадания крупных твердых частиц в датчик и дополнительно служащее для увеличения расхода потока отработавших газов в датчик в сборе. 4 н. и 15 з.п. ф-лы, 14 ил.

ИНДУЦИРОВАННАЯ ВЫСОКОИНТЕНСИВНЫМ ФОКУСИРОВАННЫМ УЛЬТРАЗВУКОМ КАВИТАЦИЯ С УМЕНЬШЕННЫМ ПОРОГОМ МОЩНОСТИ

Группа изобретений относится к области медицины, а именно к молекулярной диагностике. Устройство для подвергания жидкой пробы воздействию акустической энергии путем создания кавитации в жидкой пробе содержит источник высокоинтенсивных ультразвуковых волн и картридж, содержащий жидкую пробу и границу раздела жидкость-воздух. При этом устройство выполнено с возможностью фокусировать высокоинтенсивные ультразвуковые волны так, что с помощью картриджа, вмещенного в устройство, создается фонтан жидкости над границей раздела жидкость-воздух внутри картриджа, а капля фонтана, возвращающаяся обратно из фонтана в жидкую пробу, является элементом зародышеобразования. Группа изобретений относится также к системе и способу подвергания жидкой пробы воздействию акустической энергии, а также к машиночитаемому носителю информации с компьютерной программой для осуществления указанного способа. Группа изобретений обеспечивает обработку пробы фокусированной акустической энергией для создания в пробе неоднородной ...

ПЕРЕМЕШИВАЮЩЕЕ ИЛИ ДИСПЕРГИРУЮЩЕЕ УСТРОЙСТВО

Изобретение относится к перемешивающему или диспергирующему устройству и может использоваться для обработки различных сред. Устройство имеет герметично закрытую смесительную камеру, рабочий орган, вращающийся в смесительной камере вокруг центральной оси и имеющий стержневидный элемент для передачи силы привода на этот рабочий орган, и привод, находящийся вне смесительной камеры. Стержневидный элемент на входе в смесительную камеру соединен с мембраной, которая является частью стенки смесительной камеры. Стержневидный элемент выполнен с возможностью приведения его в качательное движение при помощи привода, так что его конец, находящийся внутри смесительной камеры, выполняет круговое движение. Рабочий орган снабжен измельчающими элементами или шариками, помещенными в смесительную камеру. Технический результат состоит в достижении оптимального результата перемешивания, диспергирования или измельчения. 2 з.п. ф-лы, 5 ил.

СПОСОБ ПОДГОТОВКИ И ОТБОРА ПРОБ В ГРУНТАХ СО СКАЧКООБРАЗНЫМ ИЗМЕНЕНИЕМ РЕЛЬЕФА

Изобретение относится к области экологических измерений. Раскрыт способ подготовки и отбора проб в грунтах, основанный на рекогносцировочном осмотре заданной территории, ее разбиении на элементарные участки в соответствии с сеткой, определении расстояния между точечными пробами, отборе пробы в пределах элементарного участка, смешивании проб по каждому элементарному участку. При этом рекогносцировочный осмотр местности проводят путем фотографирования территории с летательного аппарата, обрабатывают полученные снимки, на которых выделяют участки неоднородностей рельефа со скачкообразным изменением рельефа, определяют их координаты, глубину, радиус неоднородности рельефа на поверхности и диаметр дна, передают данные на наземный центр, где с использованием полученных данных на карту наносят контуры участков со скачкообразным изменением рельефа, на элементарных участках берут по меньшей мере девять проб, причем одну пробу берут в центре дна неоднородности, а также по четыре пробы равноудалено ...

УСТРОЙСТВО ДЛЯ СБОРА БИОЛОГИЧЕСКОЙ ЖИДКОСТИ И МОДУЛЬ СБОРА

... группа изобретений относится к медицинской технике. Модуль сбора, адаптированный к приему пробы, содержит корпус, имеющий впуск и выпуск, сообщающиеся по текучей среде; камеру смешивания, расположенную между впуском и выпуском; стабилизатор пробы, расположенный между впуском и выпуском; и камеру сбора, расположенную между камерой смешивания и выпуском. Камера сбора включает первый деформируемый участок и второй деформируемый участок, а также участок жесткой стенки между первым деформируемым участком и вторым деформируемым участком. Камера смешивания принимает пробу и по меньшей мере часть заключенного в ней стабилизатора пробы. Раскрыты альтернативный вариант выполнения модуля сбора и устройство для сбора биологической жидкости, содержащее модуль сбора. Технический результат состоит в обеспечении дозирования пробы при минимальном риске для пациента. 3 н. и 16 з.п. ф-лы, 24 ил.

СПОСОБ ИЗМЕРЕНИЯ КЛЕТОЧНОГО СОСТАВА СИНОВИАЛЬНОЙ ЖИДКОСТИ В ОБРАЗЦАХ С ПРИМЕСЬЮ КРОВИ

Изобретение относится к медицине, а именно к клинической лабораторной диагностике, и может быть использовано для измерения клеточного состава синовиальной жидкости в образцах с примесью крови. Проводят измерение образцов синовиальной жидкости и периферической крови на автоматическом гематологическом анализаторе с технологией флуоресцентной проточной цитометрии для анализа лейкоцитов и технологией импедансного измерения для анализа эритроцитов в синовиальной жидкости в режиме измерения биологических жидкостей (BF) и периферической крови в режиме измерения цельной крови (WB). В ходе измерения образца синовиальной жидкости в режиме BF получают данные по абсолютному количеству ядросодержащих клеток, лейкоцитов и эритроцитов с повышенной чувствительностью, относительному количеству мононуклеарных клеток. В ходе измерения образца периферической крови в режиме WB получают данные по абсолютному количеству лейкоцитов и эритроцитов, относительному количеству лимфоцитов и моноцитов. Производят одновременную ...

СПОСОБ И СИСТЕМА ДЛЯ ОБНАРУЖЕНИЯ ТВЕРДЫХ ЧАСТИЦ В ОТРАБОТАВШИХ ГАЗАХ

СПОСОБ ПРИГОТОВЛЕНИЯ РАСТВОРА МНОГОКОМПОНЕНТНОЙ ПРОБЫ ТВЕРДОГО ОБРАЗЦА БОРА

УСТРОЙСТВО ДЛЯ СБОРА БИОЛОГИЧЕСКОЙ ЖИДКОСТИ И МОДУЛЬ СБОРА

МИКРОЧИП И УСТРОЙСТВО ДЛЯ МОНИТОРИНГА КРОВИ

... 1. Микрочип, включающий в себя: ! первый канал, который обеспечивает возможность поступления первой жидкости, выбранной из цельной крови, обогащенной тромбоцитами плазмы, и жидкости из них, обработанных лекарственным средством; ! второй канал, соединенный с первым каналом, который обеспечивает возможность поступления второй жидкости, содержащей реагент, который является реакционноспособным по отношению к указанной первой жидкости; и ! объединенный канал, проходящий от участка соединения первого канала со вторым каналом, ! при этом в указанном объединенном канале предусмотрена секция перемешивания, имеющая перемешивающий якорек для смешения первой жидкости со второй жидкостью. ! 2. Микрочип по п.1, в котором поверхность указанного перемешивающего якорька была подвергнута обработке для ингибирования свертывания крови. ! 3. Микрочип по п.2, в котором указанная обработка для ингибирования свертывания крови представляет собой обработку, в результате которой по меньшей мере поверхность перемешивающего ...

Унифицированный парогенератор

УСТРОЙСТВО ДЛЯ ОТБОРА И ПОДГОТОВКИ ПРОБЫ

... 1. Устройство для отбора, подготовки и предварительного анализа пробы, которое содержит пробоотборную штангу (11) с выполненной в виде пробоотборной камеры (16) приемной структурой для размещения заданного количества пробы, и размещающую в себе пробоотборную штангу (11) приемную трубку (1), которая содержит заполненную жидкостью смесительную камеру (19) для консервации, растворения, подготовки и обработки находящихся в пробоотборной камере (16) проб, причем пробоотборная штанга (11) выполнена в виде двусторонне открытого полого тела с подвижно и уплотненно направленным в нем выталкивающим плунжером (18) для выталкивания пробы из пробоотборной камеры (16) в смесительную камеру (19), отличающееся тем, что:а) внутри пробоотборной штанги (11) предусмотрен содействующий перемешиванию элемент (20), который при выталкивании пробы выталкивающим плунжером (18) перемещается в смесительную камеру (19) и который состоит из материала с удельным весом по меньшей мере 2 г/сми/илиб) в смесительной камере ...

МЕХАНИЧЕСКОЕ УСТРОЙСТВО ДЛЯ СМЕШИВАНИЯ ПРОБЫ ТЕКУЧЕЙ СРЕДЫ С ОБРАБАТЫВАЮЩИМ РАСТВОРОМ

... 1. Устройство для приготовления пробы текучей среды, используемой в измерительном приборе исследуемой текучей среды, содержащеепервую часть, содержащуюпротыкающий перегородку выступ икапиллярный канал; ивторую часть, содержащуюкамеру обрабатывающего раствора,первую перегородку, герметизирующую камеру обрабатывающего раствора, ивторую перегородку, герметизирующую камеру обрабатывающего раствора.2. Устройство по п.1, в котором первая перегородка расположена сверху камеры обрабатывающего раствора и вторая перегородка расположена снизу камеры обрабатывающего раствора.3. Устройство по п.1, в котором протыкающий перегородку выступ протыкает первую перегородку, в результате чего капиллярный канал входит в камеру обрабатывающего раствора, когда первая часть устройства вставлена во вторую часть устройства.4. Устройство по п.1, в котором капиллярный канал расположен в протыкающем перегородку выступе.5. Устройство по п.1, также содержащееизмерительный прибор исследуемой текучей среды имеханизм на ...

Способ разбавления проб жидкости и устройство для его осуществления

... 1. Способ разбавления проб жидкости в пробоотборнике с основным и боковым каналами, включающий заполнение бокового канала пробой, нагнетание разбавляющего вещества в основной коаксиально расположенный канал за счет подсоединения источника давления и вытеснения пробы из бокового в основной канал, отличающийся тем, что, с целью повышения точности и эффективности отбора пробы, до вытеснения разбавляющего вещества из основного канала и пробы в основной канал, основной канал заполняется разбавляющим веществом, а разбавляющее вещество вытесняют из основного канала через нижний наконечник. 2. Способ по п.1, отличающийся тем, что нагнетание разбавляющего вещества в основной канал осуществляют всасыванием через нижний наконечник.3. Способ по пп.1 и 2, отличающийся тем, что нагнетание разбавляющего вещества осуществляется сверху через основной канал, снабженный клапаном. 4. Способ по пп.1-3, отличающийся тем, что одновременно с заполнением основного канала разбавляющей жидкостью заполняют разбавляющей ...

APPARAT UND METHODE ZUR ANALYSE VON IN EINER FLÜSSIGKEIT SUSPENDIERTEN TEILCHEN.

Verfahren und Gerät zur genau kontrollierten Verdünnung flüssiger Proben.

VORRICHTUNG ZUM BEHANDELN FLUESSIGER PROBEN IN PROBENBEHAELTERN

Arrangement for conditioning fluids in compartment used in e.g. biomedical field, mixes sample and conditioning fluids flowing in adjacent fluid conductors in mixing zone, where fluids are not mixed with transportation fluid

The conditioning arrangement has three nested fluid conductors through which sample fluid (11), conditioning fluid (12) and transportation fluid (13) are flowed. The sample fluid and conditioning fluid flowing in the adjacent fluid conductors are mixed in a mixing zone (9), and are not mixed with the transportation fluid. The sample fluid is comprised of the samples of inorganic and/or organic substances, bioactive molecules, cells, microorganisms and/or particles. An independent claim is included for method for conditioning fluids in compartment.

Vorrichtung für die Vorbereitung der Blutprobe für die Messung der Kaliumkonzentration in Erythrozyten an allen Blutgasanalysatoren

Es ist zum ersten Mal in der klinischen Medizin möglich, die Kaliumkonzentration in Erythrozyten zu am Patientenbett zu messen. Dieser Parameter hat ein großes diagnostisches und wissenschaftliches Potential und eröffnet neue therapeutische Perspektiven. Aus wissenschaftlicher Sicht bekommen wir einem tieferen Blick in interne Kaliumbilanz - unsere Kenntnis über Elektrolytenstatus des Körpers bekommt eine neue Dimension.Bis dato ist dieser Parameter (Kaliumkonzentration in Erythrozyten) in klinischer Medizin völlig unbekannt.Die Herstellung die beschriebenen Einmalartikeln für die Blutprobevorbereitung ist technologisch gesehen für dieMedical Industrie sehr einfach, die Einführung in die klinische Praxis wird zu einer großer praktisch relevante Innovation in der klinischen Medizin.1. Die heute zu Verfügung stehenden Methoden für die Messung der Kaliumkonzentration in Erythrozyten sind atomare Spektrometrie und Flammenfotometrie. Beide Verfahren sind sehr aufwendig und haben sich in die ...

Method and device for the metering, dilution and deproteinisation of biological fluids

The invention relates to a method and a device for the metering, dilution and deproteinisation of biological fluids in a single step in that a cannula (3) through which a defined amount of sample is usually aspirated and ejected again together with a subsequent diluting solution, is surrounded in its upper part by a short annular space (5) which is connected to a metering device (11) for a deproteinisation agent. The deproteinisation agent is forced through the outlet opening of the annular space (5) simultaneously with the ejection of the sample and the diluting solution and flows along the outer surfaces of the cannula (3) as a result of which the latter is cleaned in such a way that there is no interfering carryover of sample even without further cleaning steps. Contact of the three components at the tip of the cannula leads to sufficient mixing on running into the sample container. ...

Transparent frozen soil and preparation method and application thereof

PROPORTIONAL EXHAUST SAMPLE SYSTEM

METHODS AND APPARATUS FOR PERFORMING BACTERIOLOGICAL TESTS AUTOMATICALLY

... 1372847 Automated bacteriological sampling UNILEVER Ltd 27 Oct 1971 [29 Oct 1970] 51377/70 Heading C6F [Also in Division B1] In the automated filling of Petri dishes with bacteriological components, dishes from eight stacks of twenty dishes 2, Fig. 1, are taken on carrier arms 3 through stations II to receive the inoculation and a diluent, III for the addition of nutrient agar and IV for labelling, after which they are added to a stack of similarly prepared dishes (not shown). At stations II and III the dish 2 and its sub-carrier 11, Fig. 4, are rotated by a rubber driving wheel 12 whereby the contents of the dish are properly mixed together. When arm 8 moves downwardly to the inclined position shown, a second arm and cam cause the Petri dish lid to move back horizontally. In addition to ordinary delivery systems 15, a pipette dispensing system 13 transfers an inoculation sample from a pot 14 into a first dish containing diluent and thereafter transfers diluted inoculation samples sequentially ...

A method and apparatus for dilution of aerosols

Method and apparatus for investigating the properties of a solid material

Preparation of specimens

A sample preparation apparatus (100) for processing a sample arranged in a sample tube together with a solvent, the apparatus comprising: a homogenizer (300), operable to agitate the sample tube and so assist the sample to dissolve in the solvent; a centrifuge (400), operable to separate insoluble materials from a desired solution; and a robotic system (110) arranged to transport a sample tube holder (220), e.g. a rack, or a carrier, comprising the sample tube (230), between the homogenizer and the centrifuge, and wherein the sample tube holder is arranged to be securely attachable to, and detachable from, the homogenizer and the centrifuge.

Methods and apparatus for sampling and diluting concentrated emulsions

Devices, systems and methods for the collection, stimulation, stabilization and analysis of a biological sample

Improved means for measuring quantities or doses of granular or powdered materials

... 234,220. Charlton, S. J. W. March 15, 1924. Measures of capacity.-A disc, plate, or disc b of desired size is attached permanently or temporarily to an elongated wire handle a so that it may be dipped into a bottle &c. and separate a predetermined dose or quantity of powder. The disc or the like is attached at its centre at rightangles to the handle.

Corpuscle sorter

... 1,103,190. Electrostatic separators. UNITED STATES ATOMIC ENERGY COMMISSION. 1, Feb., 1966 [4, June, 1965], No. 4344/ 66. Heading B2J. [Also in Division G1] In an. apparatus for sorting particles suspended in a liquid, a jet of the liquid is broken into a regular train of droplets by accoustic pulses and a sensor 29 measures a selected characteristic of each particle that passes it and causes an electrostatic charging collar 37 to charge each droplet in accordance with the measured characteristic of any particle it may contain. Electrostatic deflecting plates 39, 41 then direct each droplet into an appropriate collecting vessel or onto an appropriate portion of a moving strip of blotting paper. The selected characteristic may be size, radioactivity, fluorescence, luminescence, electrical conductivity, or light transmissibility. or reflectivity. The particle concentration should be such that about one in seven droplets will contain a particle and the collar 37 should charge one or more droplets ...

Gas mixing system for >an> ion source

A gas mixing system is used to mix an analyte gas with a carrier gas before ionization of the mixed gas. The ionized mixed gas may then be supplied to a mass spectrometer. A discrete volume 21 of a sample gas is supplied at a first, relatively low pressure to a mixing chamber 37. A mixer gas 18 at a higher pressure is mixed with the sample gas in the mixing chamber 37. The output of the mixing chamber is a mixed gas at a pressure higher than the first pressure and is supplied to an ionization device 50. After supplying a sample to the ionisation device, the mixing chamber can be purged using a vacuum system 32, 35. The system is particularly suited for use with uranium hexafluoride as the sample gas and an inert gas such as argon as the mixer gas.

Apparatus and method for liquid sample introduction

A method and apparatus for mixing droplets of liquid sample and droplets of a diluent and/or a standard produced by droplet-on-demand generators for use with an analysis device. Two different liquids may be introduced to an analysis device for simultaneous analysis. The method comprises using a first droplet-on­ demand generator (550) to provide a first stream of droplets of a first liquid; using a second droplet-on-demand generator (551) to provide a second stream of droplets of a second liquid; and combining the first and second streams of droplets before they enter the analysis device. The first and second streams of droplets may be combined with a gas stream e.g. an inert gas. The analysis device may be an atomic absorption spectrometer, an inductively coupled plasma optical emission spectrometer or a mass spectrometer.

Couette devices

Pipette assembly

... 962,356. Pipette assemblies. H. W. GERARDE. Feb. 16, 1962, No. 6103/62. Heading SIX. A pipette assembly for preparing blood count solutions comprises a capillary tube 15 held in a tubular mounting 16 and a reservoir 17 having an opening and a flexible and resilient part, the reservoir containing a volume of diluent 24, and the mounting being arranged to fit in and seal the reservoir with the tube extending into the reservoir, whereby in operation the capillary tube is filled with blood by capillary action, the flexible and resilient part of the reservoir is squeezed and the tube is inserted into the reservoir so that the mounting closes the opening and the blood is sucked into the diluent. In a preferred embodiment the other end of the mounting tube is then connected to the reservoir to discharge the sample through the capillary tube. As shown in Fig. 2, to which the above numerals refer, the reservoir may be sealed by plug 26 with enlarged head portion 25 displaceable into the reservoir ...

Method and apparatus for powder dispersion

A sample dispersing device 100 for providing a substantially uniform dispersion of particles, comprises: a surface 4 for bearing a sample, a flow channel 9 connecting an inlet opening 1 and an outlet opening 2; the device being operable to disperse the sample when a fluid flows through the flow channel from the inlet opening, over the surface, to the outlet opening, and wherein the surface faces towards the inlet opening and is configured to remain intact during dispersion. A funnel 6 may be provided for increasing the velocity of the sample flowing towards the inlet opening. Preferably, the device has an axis substantially co-incident with an axis of the inlet opening and an axis of the outlet opening. A sample dispersing apparatus (200, fig 5) may comprise the sample dispersing device, a housing for forming a dispersion chamber when closed off at a base of the housing (201, fig 5), and an adapter (203, fig 5) for positioning the sample dispersing device adjacent to an entrance to the ...

Dilution system and method

METHOD AND DEVICE FOR DETERMINATION OF SKIN TYPE

... 1437552 Reciprocating pumps EI MOCHIDA 28 March 1974 [10 April 1973] 13799/74 Heading F1A [ Also in Divisions B 1 and G1] A pump for preparing diluted liquids with desired degrees of dilution comprises a resilient tube T, e.g. of silicon resin, abutting a flat plate I a plurality of pressing members P 0 , P 1 and P 3 being operable as pinch valves on the tube and pressing members P 2 , P 2 1 being operable as pumping members for discharging liquid from the tube, a branch tube T' extending from tube T to a pipette C, and tube T being connected to a diluent reservoir FL at one end and to a charging tube N at the other end. A turntable Ta carries test tubes t, and charging tube N and pipette C are movable up and down by levers B2, B4 actuated by eccentrics E8, E9 to charge and discharge the test tubes, pipette C having an optional intermediate position set by a movable abutment B 5 , a joint X in operating rod B 3 taking up the excess movement of eccentric E9. Eccentrics driving the ...

Proportioning syringe

... 1,105,367. Syringe. E. P. MARBACH and J.P. MARBACH. Dec. 10, 1965 [June 11, 1965], No. 52621/65. Heading F1R. A plurality of liquids are drawn into a syringe in predetermined proportions by means of a gauge member 30 secured to the handle 26 of the plunger 12. The member 30 has a stepped free end providing axially spaced end surfaces 32 and 33 which may be successively engaged with the top surface of a flange on the barrel 11 to determine two axial positions of the plunger and thereby determine the quantity of a first liquid drawn into the syringe and a small additional quantity of a second liquid. The quantity of the second liquid may be less than the volume of a sampling needle 13 secured to the barrel. In a further embodiment, Figs. 4 and 5 (not shown), two axial positions of the plunger are determined by engagement of a gauge member (44) with the upper surface of barrel flange (40') and the upper surface (43) of a wedge shaped member (41) on the flange, respectively.

Hydrogen collection and detection

Improvements in or relating to arrangements for pneumatically effecting the discharge of liquids

... 1,009,176. Raising liquids. CKD DUKLA, NARODNI PODNIK. June 29, 1962 [June 30, 1961], No. 381/65. Addition to 961,332. Divided out of 1,009,175. Heading F1R. Pneumatic suction or pressure impulses for effecting the discharge of liquids as in the parent Specification, are obtained by rocking a U-tube 27 partly filled with liquid, the magnitude of the impulses being determined by the volume of U-tube enlargements 28, 29. In another embodiment, the impulses are produced by raising or lowering a tube in a constant level reservoir. An application of the device is described for filling a photometric vessel.

A real-time vapour extracting device

APPARATUS FOR AND A METHOD OF PRODUCING AN EXPONENTIAL DILUTION IN STREAK FORM

... 1455953 Exponential dilution of microorganisms MPJ DEVELOPMENTS Ltd 28 May 1975 [28 May 1974] 23566/74 Heading C6F A method of estimating the number of viable micro-organisms in liquid samples comprises supplying a sample to a carrier, continuously feeding diluent to the sample in the carrier, transferring an increasingly diluted sample to the surface of a culture medium and producing constant velocity relative motion between the carrier and the surface in order to produce a streak of diluted sample on the surface which varies exponentially in concentration from the origin to the end of the streak. A suitable apparatus for producing a spiral streak comprises a diluting head 9 including a sample carrier 10, means for feeding-diluent via tube 20 to the sample carrier at a constant rate (e.g. piston 22a in cylinder 22 moved by rack and pinion drive 25), a turn-table 1 to support a medium in culture plate P, a motor 7 for rotating the turntable and rack and pinion drive 4 for displacing the ...

APPARATUS FOR AND METHOD OF MEASURING AND ADJUSTING THE CONCENTRATION OF A FLUID SUSPENSION OF PARTICLES

Dosage pumps

A dosage pump for accurately dispensing small quantities of liquids has a piston (32) with two different diameter portions which extend through opposite sides of a pump chamber (3). Reciprocation of the piston (32) changes the internal volume of the chamber (3) unoccupied by the piston and affords a pumping action. Since the differences in diameter of the piston portions can be made very small, even with moderate stroke lengths small quantities of liquid can be dispensed with accuracy. Provision is made for adjustment of the stroke length to provide for variation in delivered volume. The pump is suitable for use in analytical applications. ...

Sampling apparatus

A sampling apparatus is described which comprises an aspiration probe and a sample inlet assembly. The probe comprises coaxial inner 48 and outer tubes 50 joined at the sampling end so as to close the space between the tubes. A plurality of small diameter holes 54, 56, 58, 60 extend through the inner tube. The holes are axially and circumferentially spaced, and allow a diluent to be accurately and thoroughly mixed in said probe with an aspirated fluid sample. The sample is sucked into the probe through the open end of the tubes 48. The sample inlet assembly comprises a housing having a plurality of sealing septums through which the probe can be extended and retracted. The septums are spaced apart to define fluid chambers therebetween, and a fluid inlet extends into each chamber, whereby calibrating fluids can be introduced into the probe from the fluid chambers. ...

Mechanical device for mixing a fluid sample with atreatment solution

Mechanical device for mixing a fluid sample with atreatment solution

METHOD FOR METERING HYDROCARBONS

Method for assaying hydrocarbons

A liposomal composition comprising a sterol-modified lipid and a purified mycobacterial lipid cell wall component and it's use in the diagnosis of tuberculosis

Method for assaying hydrocarbons

A liposomal composition comprising a sterol-modified lipid and a purified mycobacterial lipid cell wall component and it's use in the diagnosis of tuberculosis

Mechanical device for mixing a fluid sample with atreatment solution

Method for assaying hydrocarbons

AUTOMATIC SAMPLE PREPARATION PROCEDURES AND - DEVICES

VERFAHREN UND ANORDNUNG ZUR INDIREKTEN MASSENDURCHFLUSSBESTIMMUNG

MIXING AND DISTRIBUTING HOMOGENEOUS CONNECTIONS OF A REACTANT ON A SURFACE

PROCEDURE AND DEVICE FOR THE PRODUCTION OF PRIMARY STANDARD GAS MIXTURES

DEVICE AND PROCEDURE EXHIBITING A RETRACTABLE MIXING ELEMENT

MODULAR DEVICE FOR THE ANALYSIS OF A BIOLOGICAL LIQUID, LIKE E.G. BLOOD

VERFAHREN UND ANORDNUNG ZUR INDIREKTEN MASSENDURCHFLUSSBESTIMMUNG

Determining a measurement value for a measurement component in a raw gas representative raw gas

Verfahren und Vorrichtung zur Ermittlung eines für einen Messbestandteil (2) in einem Rohgas (3) repräsentativen Rohgasmesswerts (110). Das Rohgas (3) wird als Rohgasstrom (r) einer Verdünnungseinheit (6) zugeführt und in der Verdünnungseinheit (6) gemäß einer vorgegebenen Verdünnungsrate (104) mit einem Verdünnungsgasstrom (v) zu einem Messgasstrom (m) verdünnt. Der Messgasstrom (m) durchströmt eine Messzelle (7), welche einen Messgasmesswert (109) ermittelt. Aus zumindest der Verdünnungsrate (104) und dem Messgasmesswert (109) wird der Rohgasmesswert (110) ermittelt. Es wird ein Rohgaseinflussgrößenwert ermittelt, der für eine Einflussgröße des Rohgases (3), insbesondere ein Rohgasdruckwert (101) und/oder ein Rohgastemperaturwert, repräsentativ ist, wobei aus dem Rohgaseinflussgrößenwert ein Rohgas-Korrekturfaktor (108) ermittelt wird.

PROBENAUFGABEVORRICHTUNG FÜR EINE EINRICHTUNG ZUR BESTIMMUNG DER SAUERSTOFFKONZENTRATION EINER PROBE

VERFAHREN ZUR ENTNAHME EINES TEILSTROMES AUS EINEM ABGASSTROM UND EINRICHTUNG ZUR DURCHFÜHRUNG DES VERFAHRENS

PROCEDURE AND ARRANGEMENT FOR THE INDIRECT MASS FLOW REGULATION

PROCEDURE AND DEVICE FOR THE SUPPLY OF GAS MIXTURES INTO A ANALYZER

APPARATUS AND METHOD TO THE ANALYSIS OF PARTICLES SUSPENDED IN A LIQUID.

SIMPLIFIED WITHDRAWAL AND DISTRIBUTION DEVICE FOR AN AUTOMATIC BLOOD ANALYZER.

PROCEDURE AND EQUIPMENT FOR EXACTLY THE CONTROLLED DILUTION OF LIQUID SAMPLES.

DEVICE OF TASK OF SAMPLE FOR A MECHANISM FOR THE DETERMINATION OF THE SAUERSTOFFKONZENTRATION OF A SAMPLE

VERDÜNNUNGSUND MIXTURE CARTRIDGE.

DEVICE AND PROCEDURE FOR TREATING LIQUID SAMPLES.

PROCEDURE FOR THE DISSOLUTION OF SILICATES

PROCEDURE AND MECHANISM FOR THE DETERMINATION OF THE CONCENTRATION OF ORGANIC POLLUTANTS

DEVICE FOR THE DILUTION OF A SAMPLE WITH OFFSET MIXING CHAMBER

TREATMENT A METAL OF A CONTAINING WASTE FOR THE RECUPERATION OF THE METAL

ARRANGEMENT AND PROCEDURE FOR COLLECTING AND DETERMINATION OF HYDROGEN

MORE DISPENSER

PROPORTIONAL VOLUME MIXER WITH A IN TWO DIRECTIONS IN ONE LEVEL MOBILE ONE SYRINGE AND MODULAR ONE OF EMPLOYMENT BASKETS FOR CONTAINERS

Device for the automatic maintenance of the fluid level in the storage vessel of dosing equipment for the release of measured test liquid by a positive pressure impulse

Continuous procedure for automatic proportioning of two different liquids

ALIQUOTIEVERFAHREN TO THE AUTOMATIC SAMPLE ANALYSIS

SAMPLE DILUTION

Heparin-based blood sampler without platelet activation

The present invention relates to blood sampler and the preparation of blood samples that can be used for not only for blood gas, basic metabolic panel parameter analysis but also for a platelet count and/or white blood count, such as a 3-diff or 5-diff. The blood samples comprise at least one anticoagulant for the determination of blood gas and basic metabolic panel parameters and at least one anti-platelet agent.

Method and apparatus for linear and rotational container agitation

A linear actuator member (128) applies a vertical force to a vessel (112) or to a holding apparatus in which a vessel (112) is contained. A linear to angular motion constraining member such as a cage structure (114) having a helical track (115) translates linearly directed force and motion applied by the linear actuator member (128) into a combined linear and rotational motion of the vessel (112). The combined vertical and rotational motion of the vessel (112) in response to the vertical force is repeatable according to a predefined agitation pattern for mixing components in the vessel (112).

Nozzle for a polarizer for dynamic nuclear spin polarisation (DNP)

Device for a continuously operated diluting of a slurry sample

Systems and methods for analyzing body fluids

Systems and methods analyzing body fluids contain cells including blood, bone marrow, urine, vaginal tissue, epithelial tissue, tumors, semen, and spittle are disclosed. The systems and methods utilize an improved technique for applying a monolayer of cells to a slide and generating a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and method for utilizing multi-color microscopy for improving the quality of images captured by a light receiving device.

Sample preparation and testing system

The invention concerns a sample preparation and testing system (10) with a 5 mixing container (1, 18), where an indicator element (2, 40, 58, 60) is located inside the mixing container (1, 18) that has the function of a shaking indicator. (Figure 12) m2U319UUU 2/13 Fig. 3A 6 Fig. 3B 6 ...

Apparatus and method for a lysis of a sample, in particular for an automated and/or controlled lysis of a sample

The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive a vial (100), wherein the vial holder (90) is arranged on the disc (31), at least one driving device (20) which is configured to rotate the disc (31) and the vial holder (90), at least one heating device (60) which is configured to heat the sample to a determined incubation temperature, and - at least one control device (70) which is configured to control the driving device (20) and/or the heating device (60) by means of a timing and/or step control, and/or - at least one transmitting device (80) for inductive coupling for energy and signal transmission, which is configured to transmit the energy for heating to the heating device (60), and/or - wherein the driving device (20) is configured ...

Multi plane mixer and separator (MPMS) system

The present disclosure provides a multi plane mixer and separator (MPMS) system. The system comprises a base frame of predetermined shape configured to form a base for the MPMS system. A motor is mounted to the base frame for rotating the MPMS system. A ball joint mechanism is fixed to the motor using a link and other end of the ball joint mechanism is coupled to a fork. A container holding frame is connected to the fork using bars, wherein said container holding frame is capable of tilting up to 120° with respect to the base frame. And an MPMS container of predetermined shape detachably mounted on the container holding frame for mixing fluids of different density.

Geothermal heating and/or cooling system grout testing

A subterranean grouting method comprising (a) placing a sample of a grout mixture within a test container, (b) separating a sand component from the sample, (c) determining if the grout mixture exhibits a thermal conductivity within a predetermined thermal conductivity threshold based upon a proportion of the sand component within the sample, and (d) upon determining that the grout mixture exhibits a thermal conductivity with the predetermined thermal conductivity range, securing a conduit within a subterranean bore with the grout mixture, wherein (a), (b), (c), and (d) are carried out proximate each other at a job site.

Sample extraction device and methods of use thereof

The presently disclosed subject matter provides devices and methods for sample extraction from a swab during biological sample processing. In particular embodiments, the devices and methods are configured for use in conjunction with microfluidic devices for sample processing.

Стенд для газодинамических испытаний

Полезная модель относится к области анализа материалов путем определения их химических и физических свойств, а именно, к подготовке образцов для исследования путем их разбавления, распыления и смешивания. Предлагаемый стенд для газодинамических испытаний может быть использован при оценке аналитических эксплуатационных характеристик, а также показателей надежности технических средств химического контроля (ТС ХК) в условиях моделирования воздействия парогазовой смеси (ПГС) на испытуемые ТС ХК не только в нормальных климатических условиях, но и при различных климатических воздействиях (при температурах от минус 50°С до 60°С). Техническим результатом, обеспечивающим приведенную совокупность признаков, является возможность контроля создаваемой концентрации целевого компонента ПГС с заданной точностью в режиме реального времени, что в условиях отрицательных или положительных температур позволяет оперативно изменять параметры работы отдельно взятых блоков установки, направленных на создание ПГС в заданном диапазоне концентраций целевого компонента и проведении испытаний ТС ХК. Полезная модель стенда для газодинамических испытаний состоит из газодинамической установки, содержащей: диффузионный дозатор с переменной поверхностью испарения целевого компонента, смеситель газовых потоков для смешения газа-носителя и чистого воздуха, систему разбавления, включающую несколько последовательно расположенных ступеней, каждая из которых состоит из капилляра и фильтра-поглотителя, создавая парогазовую смесь с заданной концентрацией, которая поступает в установленный внутри камеры холода, тепла и влаги теплообменный радиатор, где достигается и поддерживается единая температура ПГС и испытуемого образца, а также осуществляется постоянный контроль концентрации целевого компонента в ПГС в режиме реального времени путем непрерывного попеременного отбора ПГС на две сорбционные трубки с последующей десорбцией пробы в кварцевую капиллярную колонку газового хроматографа и детектированием ...

System for creation of formulations and generation of denaturation graphs

A system for automatically creating a denaturation curve is disclosed. In accordance with certain embodiments, a movement system including a unit having a plurality of cannulas is used. The cannulas are in fluid communication with a fluid system, which allows the cannulas to draw in and dispense fluid. A measurement system is included which draws fluid from a well into a detector to determine a characteristic of the fluid. A controller is used to control these systems and also to create a denaturation graph from the measured characteristics. In another embodiment, a plurality of formulations may be created using the system.

Cell isolation apparatus

A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.

Sample measuring apparatus and sample measuring method

A sample measuring apparatus of measuring a component in a biological sample, comprising: an input section for inputting a sample species of a biological sample; a measurement sample preparation section for preparing a measurement sample by mixing the biological sample with a reagent; a first measurement section; a second measurement section being different from the first measurement section; a measurement sample supply section for supplying the measurement sample prepared in the measurement sample preparation section to at least one of the first measurement section and second measurement section; and a control section for controlling the measurement sample supply section based on the inputted sample species.

Sample measuring apparatus and sample measuring method

A method for analyzing blood cells in a whole blood sample obtained from a cat is provided. An electrical measurement result and an optical measurement result of the whole blood sample are acquired. The electrical measurement result is obtainable by electrically measuring blood cells in the whole blood sample and the optical measurement result is obtainable by optically measuring blood cells in the whole blood sample. On the basis of the electrical measurement result and the optical measurement result, volume of red blood cells in the whole blood sample is calculated.

Automatic dilution for multiple angle light scattering (mals) instrument

A method for detecting and identifying a particle in a liquid, the system comprises controlling the provisioning of a water sample using a computer controlled metering pump; mixing the water sample with particle free filtered water to provide a diluted water sample when required; at the end of a measurement interval, determining a Total Counts Per Minute (TCPM) for the diluted water sample; determining an additional counts per minute from the sample (SCPM) for the diluted water sample; if the SCPM is greater then a Lower Optimum count Rate (LOCR) and less than a Upper Optimum Count Rate (UOCR), then setting a dilution ratio (DR); and correcting an events classification based on the DR.

Enhanced spot preparation for liquid extractive sampling and analysis

A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.

On-line sampling from a process source

An online sample manager of a liquid chromatography system includes a fluidic tee having a first inlet port, a second inlet port, and an outlet port. A diluent pump moves diluent from a diluent source to the first inlet port of the fluidic tee. A valve has a fluidic intake port connected to a process source for acquiring a process sample therefrom. A pumping system moves the acquired process sample from the valve into the second inlet port of the fluidic tee where the process sample merges with the diluent arriving at the first inlet port to produce a diluted process sample that flows out from the outlet port of the fluidic tee.

System and method for preparing samples

A system and method for preparing samples for analyte testing. The sample preparation system can include a freestanding receptacle. The method can include providing a liquid composition comprising a source and a diluent, and positioning the liquid composition in a reservoir defined by the freestanding receptacle. The method can further include filtering the liquid composition to form a filtrate comprising an analyte of interest, removing at least a portion of the filtrate from the sample preparation system to form a sample, and analyzing the sample for the analyte of interest.

Liquid handling plunger for a biological sample in a tube

A plunger for mixing a biological sample with a reagent in a tube is moved up and down reciprocally to agitate the biological sample and the reagent for subsequent extraction of the material from the mixture to be analyzed. The plunger's agitation facilitates the concentration of the extracted material to reach an extent where a correct analysis is possible. The plunger of the present invention has a shape of a hollow cylinder with an aperture at the bottom, a plurality of slots formed on the cylindrical surface, and an opening formed at the top. The plunger allows a pipette to draw the extracted material in the test tube out from the opening at the top of the plunger without removing the plunger, and prevents drawing out the fragments of the sample after the biological sample and the reagent have been sufficiently mixed.

Rapid analyte collection and testing device

A rapid analyte collection and testing device, said device comprising a) a casing, said casing having) a first casing section, said first casing section containing an encapsulated buffer section containing a buffer, and asecond casing section, said second casing section comprising a window on a side of said second section, a complementary mechanism for attachment to said first casing section, an opening at a proximal end of said second casing section; and a non permeable platform strip positioned lengthwise within and extending beyond the second casing section. The non-permeable platform further contains a swab, said swab positioned at the distal end of said non-permeable platform strip, a lateral flow assay positioned downstream from said swab, and a tag, positioned upstream from the capture reagent site.

Method of Pooling and/or Concentrating Biological Specimens for Analysis

The present invention provides methods for concentrating and pooling liquid suspensions of biological specimens containing analytes of interest in a dry state. The dried biological specimens containing analytes of interest are reconstituted and released from the matrix for subsequent analysis in concentrated form.

HIGH THROUGHPUT AND VOLUMETRIC ERROR RESILIENT DILUTION WITH DIGITAL MICROFLUIDIC BASED LAB-ON-A-CHIP

Systems and methods are provided for producing fluids with desired concentration factors from the given supply of any two concentration factors, one greater than the target CF and one less than the target CF, of the same fluid. According to one embodiment, a method is provided that stores intermediate waste droplets from a sequence of mix and split steps and repeats certain steps of the sequence using the stored intermediate waste droplets. Such a method may produce additional target CF droplets faster than repeating the entire sequence. In another embodiment, a method of volumetric error resilient target CF droplet generation has been described, and includes reusing the stored intermediate waste droplets and involves a collection of capacitive sensing circuits associated with some electrode platforms. 1. A method for producing a number (M) of diluted fluid droplets having a target concentration factor (CF) on a digital microfluidic (DMF) biochip , the biochip comprising a plurality of DMF-based electrode platforms arranged to carry out a sequence of mixing and splitting steps , the method comprising:determining a target CF for a end resultant fluid mixture;expressing the target CF as an N-bit binary fraction; mixing together two input sample fluid droplets having different CFs to produce a first resultant mixture having a given resultant CF;', 'splitting the first resultant mixture into a first resultant droplet and a second resultant droplet;', wherein when the N-bit binary fraction is a first binary value indicating that the resultant mixture produced in the given mixing step has a resultant CF larger than the target CF, mixing the first resultant droplet with a droplet of a first one of two input sample fluids in the next mixing step of the sequence of mixing steps;', 'wherein when the N-bit binary fraction is a second binary value indicating that the resultant mixture produced in the given mixing step has a resultant CF smaller than the target CF, mixing the ...

MICROFLUIDIC SYSTEMS AND METHODS FOR REDUCING THE EXCHANGE OF MOLECULES BETWEEN DROPLETS

The present invention generally relates to systems and methods to create stable emulsions with low rates of exchange of molecules between microdroplets. 1. A method comprising the steps of:(a) providing within a carrier fluid a plurality of microdroplets comprising a first microdroplet comprising a first biological or chemical material and a second microdroplet comprising a second biological or chemical material, wherein the carrier fluid is immiscible with the first microdroplet and second microdroplet and comprises a first oil and a first surfactant at a first concentration within the first oil;(b) changing the carrier fluid, in the presence of the plurality of microdroplets, by changing (i) some or all of the first oil for a second oil, (ii) some or all of the first surfactant for a second surfactant, (iii) the first concentration to a second concentration, or any combination of (i), (ii) and/or (iii).2. The method of claim 1 , further comprising the step (c) of providing a microfluidic device and wherein step (a) further comprises providing the plurality of microdroplets and the carrier fluid in the microfluidic device and/or step (b) further comprises changing the carrier fluid within the microfluidic device.3. The method of claim 1 , wherein the first biological or chemical material and/or the second biological or chemical material comprises a tissue claim 1 , cell claim 1 , particle claim 1 , protein claim 1 , antibody claim 1 , amino acid claim 1 , nucleotide claim 1 , small molecule claim 1 , pharmaceutical claim 1 , and/or label.4. The method of claim 1 , wherein the first concentration is sufficient to stabilize the microdroplets against coalescing with each other in the first carrier fluid.5. The method of claim 4 , wherein the first concentration is determined claim 4 , at least in part claim 4 , based on stabilizing the microdroplets over a time frame determined by a reaction and/or detection of the one or more biological and/or chemical materials.6. ...

Dilution method for digital microfluidic biochips

Systems and methods are provided for producing fluids with desired concentration factors. According to one embodiment, a sequence of mix steps comprises mixing a resultant solution of a preceding mix step with one of the input solutions of the preceding mix step depending on a concentration factor of the resultant solution. If the concentration factor of the resultant solution is higher than the target concentration factor, then the resultant solution is mixed with the input solution having the lower concentration factor. If the concentration factor of the resultant solution is lower than the target concentration factor, then the resultant solution is mixed with the input solution having the higher concentration factor.

System and method including analytical units

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

Pressure Monitoring Of Whole Blood Aspirations To Determine Completeness Of Whole Blood Mixing

Methods for use with chemical analyzers aspirate a sample portion from one location to dispense it at a second location, aspirate another sample portion at that second location and dispense it at the first location, and measure the pressure values experienced inside a probe performing the aspirations and dispenses. By comparing the pressure values (or other values indicative of the viscosity or other relevant properties of the sample), the chemical analyzer can determine if the sample is sufficiently mixed or if the sample components remain separated and the method should be repeated. 1. A method of mixing a sample comprising the steps of:(a) aspirating a first portion of a sample to be mixed from a first level within a vessel containing the sample;(b) dispensing the first portion of the sample at a second level within the vessel;(c) measuring a first set of one or more values relating to at least one property of the first portion of the sample during at least one of the steps of aspirating or dispensing the first portion of the sample;(d) aspirating a second portion of the sample to be mixed from approximately the second level within the vessel;(e) dispensing the second portion of the sample at approximately the first level within the vessel;(f) measuring a second set of one or more values relating to the at least one property of the second portion of the sample during at least one of the steps of aspirating or dispensing the second portion of the sample;(g) comparing the first and second set of values to determine a difference of the at least one property of the first and second samples;(h) determining whether the difference of the at least one property of the first and second samples meets predetermined criteria; and(i) transferring at least a third portion of the sample to perform an assay in response to the determining step.2. The method of claim 1 , wherein the sample is whole blood.3. The method of claim 1 , wherein the sample is a fluid having components ...

SOLID REAGENT DISSOLVING DEVICE AND METHOD OF DISSOLVING SOLID REAGENT BY USING THE SAME

A solid reagent dissolving device including a flexible layer; an upper plate disposed on the flexible layer; and a lower plate disposed under the flexible layer, wherein the upper plate comprises a plurality of minute channels, a dissolution chamber connected with the plurality of minute channels, and a protrusion for limiting a flow of a fluid flowing through one of the plurality of minute channels, the lower plate comprises a plurality of penetration holes that correspond to the protrusion and the dissolution chamber, respectively, and one side of each of the plurality of penetration holes, the plurality of minute channels, and the dissolution chamber are covered with the flexible layer, and method of using same. 1. A solid reagent dissolving device comprising:a lower plate;a flexible layer disposed on the lower plate; and a plurality of channels;', 'a dissolution chamber in fluid communication with the plurality of channels; and', 'at least one protrusion that limits flow of fluid through at least one of the plurality of channels;, 'an upper plate disposed on the flexible layer, wherein the upper plate comprises'}wherein the lower plate comprises a plurality of penetration holes in regions of the lower plate that correspond to the protrusion and the dissolution chamber of the upper plate, respectively; andwherein the flexible layer covers each of the plurality of penetration holes, the plurality of channels, and the dissolution chamber.2. The solid reagent dissolving device of claim 1 , further comprising a cover positioned on the upper plate and covering at least a portion of the dissolution chamber.3. The solid reagent dissolving device of claim 1 , wherein a portion of the upper plate corresponding to the dissolution chamber is parallel with the flexible layer.4. The solid reagent dissolving device of claim 1 , wherein each penetration hole comprises an opening in an upper side of the lower plate and an opening on a lower side of the lower plate claim 1 , ...

Sample analyzer and a sample analyzing method

Herewith disclosed is a sample analyzer comprising: a measurement section configured to perform a measurement on a sample and generate a measurement value according to the concentration of an analyte in the sample; a memory storing a calibration curve; an analysis section; an output section; and an instruction receiver. When the instruction receiver receives an instruction to perform a diluting measurement on a calibration sample, the measurement section dilutes the calibration sample by a predetermined ratio and performs a measurement on the diluted calibration sample, and the analysis section determines the concentration of the analyte in the diluted calibration sample by applying a measurement value obtained from the diluted calibration sample to the calibration curve. Information generated based on the determined concentration and the known concentration is output.

MICROFLUIDIC ELEMENT FOR THOROUGHLY MIXING A LIQUID WITH A REAGENT

A microfluidic element for thoroughly mixing a liquid with a reagent used for the analysis of the liquid for an analyte contained therein and a method thereof are disclosed. The microfluidic element has a substrate and a channel structure. The channel structure includes an elongate mixing channel and an output channel. The mixing channel has an inlet opening and an outlet opening, and is implemented to mix the reagent contained therein with the liquid flowing through the inlet opening into the mixing channel. The outlet opening of the mixing channel is in fluid communication to the output channel. The outlet opening is positioned closer to the middle of the length of the mixing channel than the inlet opening. 1. A method for providing a homogeneous thoroughly mixed liquid comprising:providing a microfluidic element having a substrate and a channel structure, wherein the channel structure includes an elongate mixing channel and an output channel, wherein the mixing channel has an inlet opening and an outlet opening in fluid communication with the output channel, wherein the outlet opening is located closer to the middle of the length of the mixing channel than the inlet opening, and, wherein the mixing channel has a feed section between the inlet opening and the outlet opening and a complementary section, downstream from the outlet opening in the flow direction and opposite to the inlet opening;allowing a flow of liquid through the inlet opening into the mixing channel;dissolving a reagent contained in the mixing channel;exerting a force on the liquid in the mixing channel;allowing the liquid to flow into the output channel through the outlet opening of the mixing channel so that thorough mixing of the liquid and the reagent occur; andflowing partial volumes from the feed section and the complementary section of the mixing channel through the outlet opening into the output channel such that mixing of the two liquid partial volumes is supported by exertion of the ...

SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples. 191.-. (canceled)92. A method for mixing the contents of a well , comprising: 'wherein the segment of the endwall extends towards the center of the well at an angle relative to the vertical axis and has a radius about a mid-plane to create a culvert, the mid-plane being defined by the first sidewall and the second sidewall and;', 'directing a pipettor to a first location in an assay cartridge having a well with an endwall comprising a segment, a first sidewall, and a second sidewall;'}dispensing a liquid from the pipettor onto the culvert of the well, wherein the radius of the culvert collects the dispensed liquid and directs the dispensed liquid towards the midline of the culvert such that turbulence is induced in the flow of the dispensed liquid.93. The method of claim 92 , wherein the pipettor is directed to a second location within the well to collect the dispensed liquid claim 92 , followed by re-dispensing the collected liquid onto the culvert of the well.94. The method of claim 92 , wherein the radius of the culvert decreases in the direction of liquid flow claim 92 , thereby forming a funnel-like claim 92 , frusto-conical segment ...

System and method including analytical units

Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.

MICROFLUIDIC DEVICE AND METHOD FOR CONTROLLING INTERACTION BETWEEN LIQUIDS

A microfiuidic device comprises a valve having electrically controllable wetting properties. The valve comprises a valve surface arranged in a closed valve space defined by at least the valve surface, a first liquid opening for leading a first liquid to the valve and a second liquid opening for leading a second liquid to the valve. The valve surface, in a first state, is sufficiently hydrophobic to prevent contact between the first liquid and the second liquid. The valve surface, in a second state, is sufficiently hydrophilic to allow contact between the first liquid and the second liquid. A ventilation outlet is provided for allowing gas to escape from the valve space.

METHOD FOR PREPARING A SAMPLE FOR ANALYSIS

A well plate () for holding samples of a bodily fluid during analysis thereof, typically in an analytical apparatus, includes a plate () having a plurality of first wells () extending downwardly therefrom for holding a sample during optical analysis of the sample, and a plurality of second wells () for holding samples during mechanical analysis of the samples. A plurality of holding wells () are provided for initially receiving and holding samples of the bodily fluid to be analysed so that samples of relatively accurate size can be pipetted from the holding wells () to the first and second wells (). 1. A method for preparing a sample for analysis , the method comprising transferring the sample into a holding well of a well plate , and transferring a measured quantity of the sample from the holding well to an analysis well of the well plate for analysis therein.2. A method as claimed in in which the sample is mixed with another constituent in the holding well prior to being transferred to the analysis well.3. A method as claimed in in which the sample is transferred to the holding well from another holding well of the well plate prior to being mixed with the constituent.4. A method as claimed in in which the sample is mixed with a reagent in the holding well.5. A method as claimed in in which the well plate comprises a plurality of the analysis wells claim 1 , at least one of the analysis wells being of a first type claim 1 , and at least one of the analysis wells being of a second type claim 1 , and the measured quantity of the sample is transferred from the holding well to one of the analysis wells of the one of the first and second types thereof.6. A method as claimed in in which respective measured quantities of the sample are transferred from one of the holding wells to one of the analysis wells of the first type claim 5 , and to one of the analysis wells of the second type.7. A method as claimed in in which the sample in the analysis well of the first type is ...

Cell analyzer, cell processing apparatus, specimen preparing apparatus

The present invention provides a cell analyzer which comprises: a cell dispersion unit which causes aggregated cells in a biological specimen to be dispersed, through a shearing force applying process of applying a shearing force to the aggregated cells and an ultrasonic dispersion process of dispersing the aggregated cells, by using ultrasonic waves; a detection unit which detects characteristics information reflecting properties of the cells in the biological specimen on which the shearing force applying process and the ultrasonic dispersion process have been performed; and an analysis unit which analyzes the cells in the biological specimen, based on a detection result from the detection unit.

Device and Method for Manipulating and Mixing Magnetic Particles in a Liquid Medium

A device for manipulating and mixing magnetic particles ( 3 ) in a surrounding liquid medium, comprises at least one couple of magnetic poles ( 1,1′ ) facing each other across a gap, the facing poles diverging from a narrow end of the gap to a large end of the gap, the poles ( 1,1′ ) forming part of an electromagnetic circuit and being arranged to provide a magnetic field gradient in the gap region; and a reaction chamber ( 2 ) that is a part of a fluidic network for containing the said magnetic particles in suspension and placed in the gap of the said electromagnets poles ( 1,1′ ). The reaction chamber ( 2 ) preferably has at least one part which has a diverging cavity, arranged co-divergently in the diverging gap between the poles.

Mixing apparatus

A mixing apparatus includes: a mixing container with a discharge port for discharging mixed liquid; a filter paper covering the discharge port to temporarily retain the liquid; a receiving unit with a waste liquid collecting portion for receiving a first liquid discharged from the discharge port through the filter paper, and a measuring portion for receiving a second liquid subjected to treatment different from treatment for the first liquid; and an operation portion for enabling selection between a first receiving state in which the waste liquid collecting portion receives the first liquid and a second receiving state in which the measuring portion receives the second liquid, and also for controlling the movement of the first liquid or the second liquid.

SAMPLER

Disclosed therein is a sampler. The sampler includes: a chamber accommodating a fluid or solid reagent therein and being sealed at both ends with penetrable films; a tube joined with the chamber at one side, the tube having a hollow portion therein; and a movable bar having a tip which is formed at one end and has a specimen extracting portion, the tip being guided and moved through a hollow portion, the tip being adapted for mixing the specimen extracted by the specimen extracting portion with the reagent so as to form a diluted solution while penetrating through one end of the chamber and adapted for quantitatively discharging out the diluted solution while penetrating through the other end of the chamber. 1. A sampler comprising:a chamber accommodating a fluid or solid reagent therein and being sealed at both ends with penetrable films; anda tip adapted for accommodating an extracted specimen therein, mixing the specimen with the reagent so as to form a reacted specimen while penetrating through one end of the chamber, and quantitatively discharging out the reacted specimen while penetrating through the other end of the chamber.2. The sampler according to claim 1 , wherein the tip comprises a specimen extracting portion for extracting the specimen.3. The sampler according to claim 2 , further comprising a movable bar formed integrally with the tip to move the tip by steps.4. The sampler according to claim 3 , further comprising a tube joined with the chamber at one side claim 3 , the tube having a hollow portion therein.5. The sampler according to claim 4 , further comprising:a guide protrusion disposed at one side of the movable bar; anda guide hole disposed in the tube for guiding a movement of the guide protrusion so as to regulate the movement of the movable bar by steps.6. The sampler according to claim 5 , wherein the guide hole is formed to regulate a discharged volume of the reacted specimen by steps.7. (canceled)8. The sampler according to claim 4 , ...

SYSTEMS AND METHODS FOR HANDLING MICROFLUIDIC DROPLETS

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel. 1. An assembly , the assembly comprising:at least one droplet formation module, wherein the module is configured to form droplets surrounded by an immiscible fluid;at least one chamber comprising an outlet, wherein the chamber is configured to receive droplets and an immiscible fluid, and wherein the outlet is positioned to receive substantially only droplets; anda channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel.2. The assembly of claim 1 , wherein the droplet formation module comprises at least one first channel adapted to carry an aqueous fluid and at least one channel adapted to ...

Microfluidic passive mixing chip

An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream. 1. A microfluidic mixing device for mixing a flow of sample with a flow of diagnostic reagent , characterized in having reliable mixing and flow at low pressure drop , wherein the device comprises:a first section, wherein flow is mixed by a first vortex mixer; anda second section, which may be upstream or downstream or both of said first section, wherein flow in said second section is through one or both of:a spiral channel, wherein partial mixing is accomplished by Dean mixing; and a second vortex mixer of opposite handedness than said first vortex mixer.2. The microfluidic mixing device of wherein said vortex mixing is at approximately right angles to the plane of the spiral.3. The microfluidic mixing device of wherein a form of vortex mixing is found in more than one place in said microfluidic mixing device.4. The microfluidic mixing device of wherein said second section comprises more than one vortex mixing site.5. The microfluidic device of wherein said microfluidic mixing device is capable at operating at a differential pressure of less than about one half of atmospheric pressure.6. The ...

Apparatus and Methods for Integrated Sample PReparation, Reaction and Detection

Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.

MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications. 178-. (canceled)79. A method for transferring a reagent to an assay unit , comprising:A) inserting a cartridge into an instrument, wherein the cartridge comprises i) an identifier, ii) an assay unit configured to run a chemical reaction that yields a signal indicative of an analyte, and iii) a reagent unit comprising a reagent, and wherein the instrument comprises a fluid transfer device comprising a programmable processor and a head configured to adhere to a pipette tip;B) reading the identifier on the cartridge and transmitting the identity of the identifier from the instrument to an external device;C) receiving by the programmable processor of the fluid transfer device a protocol from the external device, wherein the protocol is associated with the identifier and comprises instructions for transferring the reagent to the assay unit;D) transferring by the fluid transfer device a selected volume of the reagent to the assay unit, wherein the selected volume is provided in the protocol, and wherein the fluid transfer device is operable to transfer different volumes of the reagent into the assay unit.80. The method of claim 79 , wherein the cartridge further comprises a bodily fluid sample.81. The method of claim 80 , further comprising transferring by the fluid transfer device a selected volume of bodily fluid sample to the assay unit claim 80 , wherein the selected volume is provided in the protocol.82. The method of claim 81 , wherein the bodily fluid sample is diluted prior to being transferred to the assay unit.83. The method of claim 81 , further comprising prior to transferring the bodily fluid sample to the assay unit claim ...

Method for assaying hydrocarbons

A method for determining the amount of hydrocarbons in a composition including hydrocarbons and water, includes: adding a chemical agent to the composition in order to form an emulsion of water and hydrocarbons; taking a sample of the emulsion and dissolving this sample in a common solvent for water and hydrocarbons in order to form a solution; measuring the amount of hydrocarbons in the solution. An installation suitable for implementing this method is also provided.

SAMPLE PROCESSING METHODS AND SYSTEMS TO COLLECT AND DILUTE A BIOLOGICAL SAMPLE

Sample processing methods and systems to collect and dilute a biological sample. A device collects a predetermined volume of sample in one chamber, seals the chamber upon activation, and mixes the sample with a predetermined volume of reagent. 1. A system comprising:a portable housing having a sample region to receive a biological sample, a reagent region to hold a reagent, a fluid outlet, and one or more fluid paths amongst the sample region, the reagent region, and the fluid outlet; anda mechanically actuated fluid controller to dispense fluid from the sample region and the reagent region to the fluid outlet.2. The system of claim 1 , wherein the housing and the mechanically actuated fluid controller are configured to dispense the biological sample at a first rate and to dispense the reagent at a second rate that is proportional to the first rate.3. The system of claim 1 , wherein the portable housing and the mechanically actuated fluid controller are configured to dispense the biological sample and the reagent based on a pre-determined ratio.4. The system of claim 1 , wherein the sample region includes one or more sample chambers to receive the biological sample.5. The system of claim 1 , wherein the sample region includes a capillary tube.6. The system of claim 1 , wherein the housing has an opening through an end portion to receive the biological sample.7. The system of claim 1 , wherein the housing has an opening through a body portion to receive the biological sample.8. The system of claim 1 , further including a filter positioned in the sample region to filter the biological sample.9. The system of claim 1 , wherein the sample region includes a sample chamber claim 1 , a sample well to receive the biological sample claim 1 , and a fluid path to provide the biological sample from the sample well to the sample chamber.10. The system of claim 9 , wherein the sample well is configured to retain excess biological sample to prevent over-filling of the sample ...

Cassette For Sample Preparation

Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.

Handheld sampling-removal head, analysis arrangement and method for characterizing an aerosol

In a sampling head ( 1 ) of an analysis arrangement ( 31 ), provision is made that a sample stream delivered via a sampling line ( 2 ) and a dilution air stream delivered through a dilution air inlet ( 4 ) are mixed together in a dilution unit ( 3 ) in such a way that a volumetric quantity entrained in at least one receiving space moved along by a movable element ( 8 ) between the sampling stream and the dilution air stream are exchanged with each other, wherein the analysis arrangement ( 31 ) has a gas analyzer ( 35 ) for the analysis of the slightly diluted sample stream and a particle determination unit ( 32 ) for the analysis of the enriched dilution air stream.

Method for controlling the sensitivity and response point of chemical test kits for metals in paint and other media

A method of changing the response level for any chemical test kits designed for the determination of a metal or compound (such as lead) in paint and other media is disclosed. The invention solves two common problems that exist with using chemical test kits for the detection of lead in paint or other coatings and media: (1) conversion of the paint sample into particles small enough to dissolve the metal in the sample; and, (2) controlling the amount of (paint) sample that gets exposed to the chemicals. This is accomplished by using a coffee grinder or equivalent tool plus a solid (food) product to break up the paint sample into small particles and at the same time dilute the concentration of the metal, while in solid form, down to a level that results in obtaining a positive response at the desired concentration.

Automated systems and methods for detection of chemical compounds

In accordance with one embodiment of the present disclosure, a method for processing a liquid test sample includes using a needle assembly to introduce a first flow of gas through an inlet in the needle assembly into a container containing a liquid test sample and to provide an outlet from the container through the needle assembly, separating at least one volatile component from the sample in a gas and liquid separator using the first flow of gas, adsorbing the at least one volatile component onto a trapping material to provide at least one adsorbed component, and releasing the at least one adsorbed component from the trapping material to provide at least one released component.

Method For Preparing Petroleum Based Samples For Analysis of Elemental and Isotopic Species

A method of separating petroleum samples containing a hydrocarbon-soluble elemental species of interest to facilitate analysis of an elemental and/or isotopic signature. A petroleum sample is mixed with a demulsifier and separated, for example by centrifuging, into one or more intermediate organic fractions. The intermediate organic fraction(s) are mixed with a solvent such as water and a second demulsifier, then separated into one or more prepared organic fractions and one or more solvent-based fractions. Some or all of the resulting fractions are then stored for possible further processing. Optionally, the petroleum sample may be spiked with one or more of an organic standard and an inorganic standard, and the solvent may likewise be spiked with an inorganic internal standard, to facilitate later analysis. 1. A method of preparing a petroleum sample for use with one or more of elemental and isotopic signature analysis , comprising:(a) adding a first demulsifier to the petroleum sample, said first demulsifier having a known concentration of a specified hydrocarbon-soluble elemental species referred to as a species of interest;(b) separating the petroleum sample into one or more intermediate organic fractions;(c) mixing the one or more intermediate organic fractions with at least one of (i) a solvent in which a specified inorganic contaminant species is soluble and having a known concentration of the species of interest, and (ii) a second demulsifier having a known concentration of the species of interest; and(d) separating the one or more intermediate organic fractions into one or more prepared organic fractions and one more solvent-based fractions.2. The method of claim 1 , wherein one or more of the known concentrations of the species of interest in the first demulsifier claim 1 , the second demulsifier claim 1 , and the solvent are substantially zero.3. The method of claim 1 , further comprising claim 1 , before separating the petroleum sample claim 1 , spiking ...

METHOD FOR OPTIMIZING VERTICAL PROBE ALIGNMENT USING DIAGNOSTIC MIXING ROUTINES

A method and apparatus for adjusting the height of a tip of a mixing element, such as a needle probe, compares the mixing efficiency observed at two heights separated by a predetermined distance. The heights can be incrementally adjusted to determine the location of the bottom of a mixing vessel and, by extension, the approximate location for placing the mixing element for efficient mixing of solutions in the mixing vessel. 1. A method for adjusting a position of a mixing element , comprising:a) positioning the mixing element at a first vertical position in a first vessel;b) performing a first mixing test to determine a first value corresponding to the effectiveness of mixing at the first vertical position;c) positioning the mixing element at a second vertical position in one of the first vessel or a second vessel;d) performing a second mixing test to determine a second value corresponding to the effectiveness of mixing at the second vertical position; ande) comparing the first and second values to determine if a bottom of the first vessel is generally one of: at the first tested position, below the first vertical position, above the second vertical position, and between the first and second vertical positions.2. The method of claim 1 , wherein the first and second vertical positions are separated by a predetermined step size.3. The method of claim 1 , further comprising: adjusting at least one of the first or second vertical positions; and repeating at least one additional mixing test until the comparing step indicates that the bottom of the first vessel is between the first and second vertical positions.4. The method of claim 1 , further comprising: adjusting at least one of the first or second vertical positions in response to the comparing step claim 1 , such that at least one vertical position is adjusted upward by a first increment if the bottom of the vessel is above the second vertical position and adjusted downward by a second increment if the bottom of the ...

INTEGRATED DISSOLUTION PROCESSING AND SAMPLE TRANSFER SYSTEM

The invention provides a system and method for dissolution testing. The system includes multiple dissolution vessels and a dose carrier positioned above the dissolution vessels. The dose carrier holds multiple removable carousels that receive individual doses for dissolution tested. Carousels that receive tablets or sinkers typically have a first configuration, while carousels that receive baskets typically have a second configuration. The two different configurations of carousels are interchangeable on the same dose ring. The system further includes a drive head positioned above the dose carrier, the drive head having a basket arbor and a mixing paddle removably and interchangeably attached. A pipettor integral with the system transfers sample aliquots having volumes in the range of 50 μl to 1 ml from the dissolution vessels to wells of an external receptacle. 1. A system for dissolution testing , comprising:a plurality of dissolution vessels;a dose carrier positioned above the plurality of dissolution vessels;a first carousel removably disposed on the dose carrier, the first carousel configured to receive a tablet;a second carousel removably disposed on the dose carrier, the second carousel configured to receive a basket, the basket configured to receive a capsule;a drive head positioned above the dose carrier; anda basket arbor and a mixing paddle removably attached to the drive head, wherein the basket arbor and the mixing paddle are interchangeable.2. The system of further comprising:a sample transfer device integral with the system.3. The system of wherein the sample transfer device comprises a pipettor.4. The system of wherein the pipettor comprises a plurality of pipettes and a plurality of disposable pipette tips.5. The system of further comprising:an external receptacle positioned to receive a sample from the sample transfer device, the external receptacle comprising a well.6. The system of wherein a cannula is attached to the drive head.7. The system of ...

COLLECTION AND TREATMENT OF A BIOFLUID SAMPLE

A system can facilitate pre-treatment a biofluid sample for various applications for monitoring and/or tracking a subject's health. The system includes a sample collection component that can collect the biofluid sample. The system also includes a mixing component that includes a media with a material. Upon adding the biofluid sample to the mixing component, the biofluid sample mixes with the media. The system also includes a filter component that can filter the media from the biofluid sample. After the media is filtered from the biofluid sample, the biofluid sample can be provided to an analyte analysis application. 1. A method comprising:adding a biofluid sample to a media comprising a carbon-containing material, wherein the biofluid sample comprises a liquid, an analyte and at least one contaminant;mixing the biofluid sample and the media to reduce a concentration of the at least one contaminant in the biofluid sample;filtering the media from the biofluid sample,wherein the mixing and/or the filtering uses a mechanical mechanism; andproviding the biofluid sample for analysis.2. The method of claim 1 , wherein the analysis comprises the detecting the analyte in the biofluid sample.3. The method of claim 1 , wherein the carbon-containing material eliminates at least a portion of the at least one contaminant in the biofluid sample.4. The method of claim 1 , wherein the carbon-containing material comprises activated charcoal claim 1 , activated carbon claim 1 , carbon black claim 1 , graphite claim 1 , graphene claim 1 , oxidized graphene claim 1 , and/or reduced graphene.5. The method of claim 1 , further comprising collecting the biofluid sample claim 1 , wherein the biofluid sample comprises a bodily fluid.6. The method of claim 5 , wherein the bodily fluid comprises tears claim 5 , saliva claim 5 , urine claim 5 , serum claim 5 , plasma claim 5 , and/or blood.7. The method of claim 1 , wherein the analysis comprises detecting an amount of the analyte in the ...

SAMPLE PROCESSING DEVICE COMPRISING MAGNETIC AND MECHANICAL ACTUATING ELEMENTS USING LINEAR OR ROTATIONAL MOTION AND METHODS OF USE THEREOF

The present invention provides methods and devices for simple, low power, automated processing of biological samples through multiple sample preparation and assay steps. The methods and devices described facilitate the point-of-care implementation of complex diagnostic assays in equipment-free, non-laboratory settings. 2. The microfluidic device of claim 1 , wherein a plurality cam lobes and rocker arms are configured such that one full rotation of the cam shaft causes the rocker arms to place pressure on a plurality burst pouches in a temporally and spatially controlled manner.3. The microfluidic device of claim 1 , wherein the one or more cam lobes and the one or more rocker arms are configured such that after the frangible membrane seal of the one or more burst pouches has been broken claim 1 , the rocker arms remain in the closed position.4. The microfluidic device of claim 1 , wherein the cam lobes are configured such that the rocker remains in the closed position after rupturing the pouch.5. The microfluidic device of claim 1 , further comprising one or more diaphragm valves along the one or more fluidic channels claim 1 , wherein the one or more cam lobes are configured such that rotation of the cam shaft causes the cam lobes to open and/or close the one or more diaphragm valves.6. The microfluidic device of claim 1 , wherein the camshaft is configured to rotate via a wind-up spring mechanism.7. The microfluidic device of claim 1 , further comprising a sample prep chamber claim 1 , wherein the sample prep chamber comprises a vehicle for DNA capture.8. The microfluidic device of claim 7 , further wherein the rotation speed of the cam shaft and the configuration of the plurality of cam lobes and the plurality of rocker arms enables bursting of the plurality of burst pouches in a temporally controlled manner to carry out wash steps of DNA purification.9. The microfluidic device of claim 8 , wherein the microfluidic cartridge further comprises an amplification ...

METHOD FOR MEASURING THE CONCENTRATION OF A PHOTORESIST IN A STRIPPING LIQUID

The present invention discloses a method for measuring the concentration of a photoresist in a stripping liquid. In the method for measuring the concentration of a photoresist in a stripping liquid, a plurality of standard photoresist samples are prepared at first, then the spectrum of the standard photoresist samples and the spectrum of the test photoresist sample are collected, and the nth derivative of the spectrum of the standard photoresist samples and the spectrum of the test photoresist sample are taken, wherein n is an integer equal to or greater than 1, a standard curve based on the nth derivative curves and calculating the concentration of the test photoresist sample is established, the concentration of a photoresist in a stripping liquid can be measured accurately according to the standard curve. 1. A method for measuring the concentration of a photoresist in a stripping liquid , comprising the steps of:{'b': '102', 'S: preparing standard photoresist samples;'}{'b': '104', 'S: collecting the spectrum of the standard photoresist samples and the spectrum of the test photoresist sample;'}{'b': '106', 'S: taking the nth derivative of the spectrum of the standard photoresist samples and the spectrum of the test photoresist sample, wherein n is an integer equal to or greater than 1, and storing the nth derivative curves of the the nth derivative of the spectrum of the standard photoresist samples and the spectrum of the test photoresist sample; and'}{'b': '108', 'S: establishing a standard curve based on the nth derivative curves and calculating the concentration of the test photoresist sample.'}2102. The method for measuring the concentration of a photoresist in a stripping liquid of claim 1 , wherein in step S claim 1 , photoresist is coated on a glass claim 1 , an exposure process claim 1 , a developing process and an etching process are performed claim 1 , and a stripping process is simulated in a beaker by stripping the photoresist with a target weight ...

CHARACTERIZATION OF AN AROMATICITY VALUE OF CRUDE OIL BY ULTRAVIOLET VISIBLE SPECTROSCOPY

A system and a method for characterizing an aromaticity value of a crude oil sample from the weight and ultraviolet visible spectroscopy of the sample id provided. The system and method includes calculating and assigning a crude oil ultraviolet visible index and using the assigned index to calculate and assign an aromaticity value of the sample, and optionally to calculate and assign an API gravity. 1. A system for characterizing an aromaticity value of an oil sample based upon ultraviolet visible spectroscopy data derived from the sample , the system comprising:a non-volatile memory device that stores calculation modules and data, the data including ultraviolet visible spectroscopy data indicative of absorbance values over a range of wavelengths;a processor coupled to the memory;a first calculation module that calculates and assigns an index value for the oil sample based upon the ultraviolet visible spectroscopy data;and a second calculation module that calculates and assigns the aromaticity value gravity of the oil sample based upon the assigned index value.2. The system of claim 1 , further comprising a third calculation module that calculates and assigns an API gravity value to the oil sample based upon the index value.3. The system of claim 2 , wherein the first calculation module calculates and assigns the index value based on the ultraviolet visible spectroscopy data and a mass of the oil sample.4. The system of claim 1 , wherein the first calculation module calculates and assigns the index value based on the ultraviolet visible spectroscopy data and a mass of the oil sample.5. The system as in claim 1 , wherein the ultraviolet visible spectroscopy data is obtained by ultraviolet visible spectroscopy analysis is in a wavelength range from 220-500 nm.6. The system of claim 5 , wherein the ultraviolet visible spectroscopy data is obtained from an ultraviolet visible spectroscopy analysis in a wavelength range from 220-400 nm.7. A system for characterizing an ...

Manipulation of Beads in Droplets and Methods for Manipulating Droplets

The invention provides a method of circulating magnetically responsive beads within a droplet in a droplet actuator. The invention also provides methods for splitting droplets. The invention, in one embodiment, makes use of a droplet actuator with top and bottom substrates, a plurality of magnetic fields respectively present proximate the top and bottom substrates, wherein at least one of the magnet fields is selectively alterable, and a plurality of droplet operations electrodes positioned along at least one of the top and bottom surfaces. A droplet is positioned between the top and bottom surfaces and at least one of the magnetic fields is selectively altered.

Compositions and methods for diagnosing urinary tract infections

Provided herein are compositions and methods for diagnosing urinary tract infections. In particular, provided herein are compositions and methods for preparing canine urine samples and performing Raman spectroscopy detection of urinary tract infections in the samples.

APPARATUS FOR PROVIDING OBJECT TO BE MEDICALLY EXAMINED BY BLOWING

An apparatus for providing an object to be medically examined by blowing is provided where air is blown into a container in which an object to be medically examined is stored, so as to make the uniform distribution state of the object to be medically examined from the inside of the container, thereby ensuring the sameness of the object to be medically examined, which is to be extracted from the container. 1. An apparatus for placing objects to be examined (examination objects) by blowing , comprising:a container fixing means for holding a container, wherein the container is equipped with a first cap filter at the opening and contains a mixed solution with the examination objects;a suction unit with an air ejecting and sucking means, wherein the air ejecting and sucking means: is coupled to a filter for letting a solution through and blocking the examination objects, in a state where the opening of the container containing the mixed solution is coupled to the upper end of the filter; firstly ejects air to the lower side of the filter to float the examination objects in the container; and then secondly performs a suction operation to place the examination objects inside the container on the filter;a blower unit for generating, when a slide is located on the upper end of the filter on which the examination objects are placed, positive pressure in the lower end of the filter and placing the examination objects placed on the filter onto the slide; anda filter transfer means for sequentially transferring the filter onto the suction unit and the blower unit,wherein the suction unit: is coupled to the filter in a state where the opening of the container is coupled to the filter; firstly expels air to the filter so that the examination objects, settled in the first cap filter of the container, are floated and uniformly spread in the mixed solution; secondly sucks the examination objects from the container; and places the examination objects on the filter.2. The apparatus of ...

METHOD AND SYSTEM FOR IMAGING A BLOOD SAMPLE

Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described. 1. A method comprising:introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier;allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier; andacquiring at least one microscope image of at least a portion of the monolayer of cells.2. The method according to claim 1 , wherein allowing the cells in the cell suspension to settle on the base surface of the carrier to form the monolayer of cells on the base surface of the carrier comprises allowing a period of time of less than 5 minutes for the cells to settle as a monolayer on the base surface.3. The method according to claim 1 , wherein a vertical height of the carrier is between 20 micrometers and 300 micrometers.4. The method according to claim 1 , wherein acquiring the at least one microscope image comprises acquiring a plurality of microscope images claim 1 , at least two of which are provided under different conditions claim 1 , the different conditions being selected from the group consisting of: different portions of the base surface being imaged claim 1 , and different illumination conditions being used.5. The method according to claim 1 , wherein introducing the cell suspension into the carrier comprises introducing the cell suspension into the carrier claim 1 , the cell suspension having a concentration that is such that when ...

TEST APPARATUS FOR ESTIMATING LIQUID DROPLET

A method is for determining information about liquid droplet fallout during operation of a gas-liquid flare apparatus. The method includes disposing a plurality of tiles in a spaced apart fashion over a monitoring area. A gas hydrocarbon fuel is injected into the gas-liquid flare apparatus to create a combustible flow, and a test fluid is injected into the gas-liquid flare apparatus such that the test fluid is dispersed into the combustible flow. The combustible flow is combusted in in the gas-liquid flare apparatus, resulting in fallout of liquid droplets of the test fluid onto the plurality of tiles. Images of the liquid droplets on the plurality of tiles are analyzed so as to determine the information about liquid droplet fallout in the monitoring area, using a computer. The information about liquid droplet fallout may be used to estimate combustion inefficiency of the gas-liquid flare apparatus. 1. A method of determining information about liquid droplet fallout during operation of a gas-liquid flare apparatus comprising:disposing a plurality of tiles in a spaced apart fashion over a monitoring area;injecting a gas hydrocarbon fuel into the gas-liquid flare apparatus to create a combustible flow;injecting a test fluid into the gas-liquid flare apparatus such that the test fluid is dispersed into the combustible flow;combusting the combustible flow in the gas-liquid flare apparatus, resulting in fallout of liquid droplets of the test fluid onto the plurality of tiles; andanalyzing images of the liquid droplets on the plurality of tiles so as to determine the information about liquid droplet fallout in the monitoring area, using a computer.2. The method of claim 1 , further comprising determining an inefficiency of the combustion of the combustible flow based upon the information about liquid droplet fallout in the monitoring area.3. The method of claim 2 , wherein the inefficiency of the combustion is determined by forming a histogram of liquid droplet fallout in ...

Process and apparatus to detect mercaptans in a caustic stream

The present invention relates to a system to detect mercaptides or sulfides in a caustic stream. More particularly, this invention relates to an on-line analyzer for measuring mercaptides using a color changing reagent to quantify mercaptide or sulfide concentration in a caustic stream. The on-line analyzer which includes a liquid sensor which can provide valuable feedback to an operator for controlling a processing unit for the catalytic oxidation of mercaptides to disulfides in an alkaline environment.

ANALYZER AND ANALYSIS METHOD

An analysis system includes a stage that supports a sample. The analysis system includes a first supplier configured to provide a hydrophobic material on the sample, and surround an inspection region on the sample with the hydrophobic material. The analysis system includes a second supplier configured to provide an inspection liquid over the inspection region. The analysis system includes a collector configured to collect the inspection liquid. The analysis system includes an analyzer configured to analyze a component contained in the collected inspection liquid. 1. An analysis system , comprising:a stage that supports a sample;a first supplier configured to provide a hydrophobic material on the sample, and surround an inspection region on the sample with the hydrophobic material;a second supplier configured to provide an inspection liquid over the inspection region;a collector configured to collect the inspection liquid; andan analyzer configured to analyze a component contained in the collected inspection liquid.2. The analysis system according to claim 1 , further comprising:a memory that stores coordinate information of the inspection region on the sample; anda first drive mechanism that moves the first supplier to surround the inspection region with the hydrophobic material, based upon the coordinate information.3. The analysis system according to claim 2 , further comprising:a second drive mechanism that moves at least one of the second supplier or the collector above the inspection region, based upon the coordinate information.4. The analysis system according to claim 1 , whereinthe second supplier and the collector share the same nozzle.5. The analysis system according to claim 1 , whereinthe analyzer is configured to detect a metal component contained in the inspection liquid.6. The analysis system according to claim 1 , whereinthe hydrophobic material has hydrophobicity.7. The analysis system according to claim 1 , wherein{'sub': 2', '2', '2', '2', '2', '3 ...

Mixing Device

[Object] To provide a mixing device capable of accurately mixing a solution in a multi-well plate. [Solving Means] A mixing device 1 is configured to be attachable to a multi-well plate 30 and includes a casing 100, a plurality of stirrers 11, a plurality of motors 12 as a drive portion, and a mounting portion 16. The casing 100 includes a main surface portion 101 facing an upper surface 301 of the multi-well plate 30. The stirrers 11 protrude from the main surface portion 101 toward wells 31 of the multi-well plate 30. The motors 12 are disposed to the casing 100 and rotate the stirrers 11 about axes thereof. The mounting portion 16 is provided to the casing 100 and is mounted to the multi-well plate 30 to position the casing 100 on the multi-well plate 30.

MANIPULATION OF FLUIDS AND REACTIONS IN MICROFLUIDIC SYSTEMS

Microfluidic structures and methods for manipulating fluids and reactions are provided. Such structures and methods may involve positioning fluid samples, e.g., in the form of droplets, in a carrier fluid (e.g., an oil, which may be immiscible with the fluid sample) in predetermined regions in a microfluidic network. In some embodiments, positioning of the droplets can take place in the order in which they are introduced into the microfluidic network (e.g., sequentially) without significant physical contact between the droplets. Because of the little or no contact between the droplets, there may be little or no coalescence between the droplets. Accordingly, in some such embodiments, surfactants are not required in either the fluid sample or the carrier fluid to prevent coalescence of the droplets. Structures and methods described herein also enable droplets to be removed sequentially from the predetermined regions. 110.-. (canceled)11. A method for forming and collecting a plurality of droplets , the method comprising:providing a microfluidic device comprising a substrate comprising a microfluidic channel operably coupled to a fluidic region;providing a solution of an aqueous fluid containing at least one target molecule and one or more reagents for conducting a reaction with the at least one target molecule;introducing the solution of aqueous fluid into the microchannel and flowing the solution of aqueous fluid through the microfluidic channel to form a plurality of droplets of the aqueous fluid based, at least in part, on the flow of the aqueous fluid and surface tension of the aqueous fluid relative to a carrier fluid;positioning each of the plurality of aqueous droplets in the fluidic region, wherein each of the plurality of droplets is substantially surrounded by the carrier fluid;maintaining separation of each of the plurality of aqueous droplets from one another within the carrier fluid; andconducting the reaction on one or more of the plurality of droplets ...

DEVICE AND METHOD FOR PRODUCING INDIVIDUALLY PROCESSED FLUID SAMPLES

The present invention is directed to a continuous fluid sample processing device for producing individually processed fluid samples and a method for producing individually processed fluid samples. Moreover, the invention also relates to the use of the device in corresponding methods, in particular in a method for continuously mixing, incubating and analyzing a fluid sample by flow cytometry. 120. A continuous fluid sample processing device ()for producing individually processed fluid samples , the device comprising:(i) a syringe plunger pump positioned vertically with a plunger at the top and an opening at the bottom, wherein said opening is operably coupled to (a) at least one fluid sample source,', '(b) at least one sample processing fluid source,', '(c) at least one gas inlet, and', '(d) at least one outlet for transferring the fluids in the syringe plunger pump,, '(ii) a multiport pump head that connects the syringe plunger pump with'}wherein the plunger displacement space in the syringe plunger pump forms a mixing chamber, andwherein the syringe plunger pump receives fluids followed by gas, so that the gas forms at least one bubble that floats through the fluids to the top of the syringe plunger pump, thus mixing the fluids in the syringe plunger pump and accumulating at the top.2. The continuous fluid sample processing device according to claim 1 , wherein the device uses at least one gas bubble that spans the whole width of the bottom of the syringe plunger pump before the bubble floats through the fluid components to the top of the syringe plunger pump.3. The continuous fluid sample processing device according to claim 1 , wherein the at least one outlet (d) in the multiport pump head transfers the mixed fluids and the at least one gas bubble sequentially.4. The continuous fluid sample processing device according to claim 1 , further comprising:(i) at least one incubation device that mixes the mixed fluids with gas bubbles that float to the top of the ...

METHOD FOR MANUFACTURING SURFACE-ENHANCED RAMAN SCATTERING-BASED SUBSTRATE FOR DETECTING TARGET SUBSTANCE, SUBSTRATE MANUFACTURED THEREBY FOR DETECTING TARGET SUBSTANCE, AND METHOD FOR DETECTING TARGET SUBSTANCE BY USING SAME SUBSTRATE

The present disclosure relates to a method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance, by which the surface of a target substance can be easily coated with metal nanoparticles through centrifugation, a substrate for detecting a target substance manufactured thereby, and a method for detecting a target substance using the same. 1. A method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance , comprising:a step of forming a primary capture structure with a target substance and a bioreceptor bound by immersing a bioreceptor-attached substrate in a sample solution comprising a target substance;a step of disposing the substrate with the primary capture structure formed in a centrifuge and adding a solution comprising metal nanoparticles into the centrifuge; anda step of forming a secondary capture structure coating the metal nanoparticles on the surface of the target substance by operating the centrifuge.2. The method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance according to claim 1 , wherein the bioreceptor-attached substrate is one prepared by a step of attaching a bioreceptor to a substrate by immersing the substrate in a solution containing a surface modifier and a bioreceptor; and a step of attaching a blocking molecule onto a portion of the surface of the substrate without the bioreceptor attached.3. The method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance according to claim 2 , wherein the blocking molecule is one or more selected from a group consisting of bovine serum albumin (BSA) claim 2 , casein and skim milk.4. The method for manufacturing a surface-enhanced Raman scattering (SERS)-based substrate for detecting a target substance according to claim 1 , wherein the solution comprising the metal nanoparticles ...

SAMPLE EXTRACTING, DILUTING AND DISCHARGING DEVICE

A tube for mixing, diluting and preserving a sample includes a hollow first container for receiving and storing a solution, the first container having first and second ends, wherein at least the first end has a through-hole, and a transport-pin located in the through-hole of the first end having a shape closely matching to the through-hole, the transport-pin including a recess with a predetermined size. The recess is suitable to be filled by a sample, wherein the transport-pin is movable between an initial position in which the recess is positioned at least partially on the outer side of the first container, and an end position in which the recess is positioned at least partially on the inner side of the first container. 125-. (canceled)26. A tube for mixing , diluting , preserving and discharging a sample , in combination with a sample , the tube comprises a hollow first container for receiving and/or storing a solution , wherein the hollow first container having first and second ends , wherein the first end has a first through-hole suitable for inserting a sample pin having a shape matching to the through-hole , the second end has a discharge port suitable for discharging a diluted sample , wherein the hollow first container comprises first locking means for locking a sample pin in a first position and second locking means for locking the sample pin in a second position , the second locking means prevents retraction of the sample pin , and further comprising a sample pin comprising an elongated pin , a handle located at a proximal end of the elongated pin , and at least one recess with a predetermined volume formed in a distal portion of the elongated pin , wherein the handle comprises at least one locking portion corresponding to the first and second locking means , wherein the sample pin comprises pressing portions that serve to deform the handle to unlock the sample pin from the first locking means.27. The tube according to claim 26 , wherein the second locking ...

APPARATUS FOR INLINE TRACE ANALYSIS OF A LIQUID

The invention relates to an apparatus for the inline trace analysis of a liquid, preferably of an aqueous process solution, comprising: a housing (); a micro-channel () through which the liquid to be examined is allowed to flow and into which light of a light source () is coupled; a detector () for light emerging from the micro-channel (); and a user interface () for monitoring and/or operating the apparatus. The micro-channel (), the detector () and/or the user interface () are arranged in the housing () and/or are integrated into the housing (), and the housing () has a connection () for feeding the liquid in the micro-channel () and a connection () for power supply of the apparatus. 115-. (canceled)16. Apparatus for inline trace analysis of a fluid , said apparatus comprising:{'b': '1', 'a housing ();'}{'b': 2', '3, 'a microchannel (), through which the fluid to be analyzed is allowed to flow and into which light of a light source () is coupled;'}{'b': 4', '2, 'a detector () for light emerging from the microchannel (); and'}{'b': '5', 'a user interface () for at least one of monitoring or operating the apparatus,'} [{'b': 2', '4', '5', '1, 'at least one of the microchannel (), the detector () or the user interface () is at least one of arranged in or integrated into the housing (), and'}, {'b': 1', '6', '2', '7, 'the housing () has a port () for feeding the fluid into the microchannel () and a terminal () for supplying power to the apparatus.'}], 'wherein17. Apparatus claim 16 , as claimed in claim 16 , wherein either:{'b': 3', '1, 'the light source () is arranged in the housing (), or'}{'b': 1', '3', '2, 'the housing () has a port for feeding the light of the light source () into the microchannel ().'}18. Apparatus claim 16 , as claimed in claim 16 , wherein either:{'b': 1', '8', '2, 'the housing () has a port () for discharging the fluid from the microchannel (), or'}{'b': 2', '1, 'a collecting container for fluid emerging from the microchannel () is arranged ...

OPTICAL CHARACTERIZATION SYSTEM FOR A PROCESS PLANT

The present invention provides a characterization system () for performing optical characterization of a liquid sample in a process plant, comprising a sample section () for holding the liquid sample, an inlet comprising an inlet valve () adapted to control a flow of the liquid sample into the sample section (), an outlet comprising an outlet valve () adapted to control a flow of the liquid sample out of the sample section (), a pressurizer () adapted to pressurize the sample section (), an agitator () adapted to agitate at least a part of the liquid sample inside the sample section () when the sample section () is pressurized by the pressurizer (), a measuring device () adapted to perform optical characterization of the liquid sample inside the sample section () while the liquid sample is pressurized and agitated during or after agitation by the agitator, wherein the inlet valve and the outlet valve are connected to a line pipe () and the characterization system is adapted to receive the liquid sample from the line pipe through the inlet valve, characterize the liquid sample in the sample section (), and optionally return at least a part of the liquid sample to the line pipe through the outlet valve. 1. A characterization system for performing optical characterization of a liquid sample in a process plant , comprisinga sample section for holding the liquid sample,an inlet comprising an inlet valve adapted to control a flow of the liquid sample into the sample section,an outlet comprising an outlet valve adapted to control a flow of the liquid sample out of the sample section,a pressurizer adapted to pressurize the sample section,an agitator adapted to agitate at least a part of the liquid sample inside the sample section when the sample section is pressurized by the pressurizer,a measuring device adapted to perform optical characterization of the liquid sample inside the sample section while the liquid sample is pressurized and agitated, where the optical ...

Plasma Spectroscopy Analysis Method

The disclosure provides plasma spectroscopy analysis methods using a preparatory process of diluting a urine sample assumed to contain mercury or lead as an analyte metal species, and then adding a known concentration of thallium as a control metal species to the diluted urine sample; a concentration process of introducing the urine sample containing the control metal species to a measurement container, and applying an electric current across a pair of electrodes disposed in the measurement container to concentrate the analyte metal species and the control metal species present in the urine sample in a vicinity of at least one of the electrodes; a detection process; a correction process; and a quantification process. 1. A plasma spectroscopy analysis method comprising:a preparatory process of diluting a urine sample assumed to contain mercury or lead as an analyte metal species, and then adding a known concentration of thallium as a control metal species to the diluted urine sample;a concentration process of introducing the urine sample containing the control metal species to a measurement container, and applying an electric current across a pair of electrodes disposed in the measurement container to concentrate the analyte metal species and the control metal species present in the urine sample in a vicinity of at least one of the electrodes;a detection process of applying an electric current across the pair of electrodes after the concentration process so as to generate plasma, and detecting emitted light from the analyte metal species and the control metal species arising due to the plasma;a correction process of calculating a corrected value by correcting an analysis emission amount that is a net emission amount at an analysis wavelength corresponding to the analyte metal species detected in the detection process, using a control emission amount that is a net emission amount at a control wavelength corresponding to the control metal species detected in the ...

REPRESENTATIVE SAMPLING OF MULTIPHASE FLUIDS

A technique facilitates evaluation of a fluid, such as a fluid produced from a well. The technique utilizes a modular and mobile system for testing flows of fluid which may comprise mixtures of constituents, and for sampling fluids thereof. The multiphase sampling method includes flowing a multiphase fluid comprising an oil phase and a water phase through a first conduit, the oil phase and water phase at least partially separating in the first conduit, mixing together the oil phase and water phase to form a mixed bulk liquid phase by flowing the multiphase fluid through a flow mixer toward a second conduit downstream the flow mixer, sampling a portion of the mixed bulk liquid phase at location at or within the second conduit, wherein the sampled portion of the mixed bulk liquid phase has a water-to-liquid ratio (WLR) representative of the pre-mixed oil phase and water phase. 1. An apparatus for sampling a multiphase fluid , comprising:a first conduit comprising a first blind leg;a flow mixer coupled to the first conduit proximate the first blind leg;a second conduit comprising a second blind leg coupled to the flow mixer proximate the second blind leg, the flow mixer disposed in between the first and second conduit; anda sampling line coupled to a sampling port in the second blind leg, the sampling line disposed along the exterior of the second blind leg.2. The apparatus of claim 1 , wherein the apparatus is a non-isokinetic multiphase fluid sampler.3. The apparatus of claim 1 , wherein the flow mixer comprises a venturi.4. The apparatus of claim 1 , wherein the flow mixer comprises a multiphase venturi flow meter.5. The apparatus of claim 1 , wherein the first conduit is disposed in a substantially horizontal position.6. The apparatus of claim 1 , wherein the flow mixer is disposed in at least one of a substantially vertical position and a position substantially perpendicular to the first conduit.7. The apparatus of claim 1 , wherein the sampling line extends ...

Electromagnetic Assemblies for Processing Fluids

Methods and apparatus for processing fluids are described. In various aspects, a fluid processing system may include a magnetic assembly that includes a plurality of magnetic structures configured to generate a magnetic field gradient within a fluid container. The magnetic structures may be formed as a plurality of electromagnets configured to be individually actuated by a controller. Each of the electromagnets may generate a magnetic field within the fluid container. The electromagnets may be differentially actuated to create a magnetic field gradient within the fluid container to agitate, mix, or otherwise influence magnetic particles disposed within the fluid container. Activation of the electromagnets of an electromagnetic structure may generate a magnetic field gradient that influences magnetic particles in an x-y direction. In addition, activation of the electromagnets of a plurality of electromagnetic structures may generate magnetic field gradients that influences magnetic particles in an x-y direction and z-direction. 1. A fluid processing system , comprising: wherein the magnetic structure is configured to receive a fluid container defining a fluid chamber therein for containing a fluid and a plurality of magnetic particles, and', "wherein each of the plurality of electromagnets are configured to generate a magnetic field within the fluid container disposed on the center axis of the magnetic structure when an electrical signal is applied to each of the electromagnets' electrically-conductive coil; and"], 'a magnetic assembly comprising at least one magnetic structure, each magnetic structure comprising a plurality of electromagnets disposed about a center axis, wherein each of the plurality of electromagnets has an electrically-conductive coil disposed about a centerline extending toward the center axis of the magnetic structure,'}a control component coupled to the at least one magnetic structure, the control component being configured to control the ...

CONTROLLED BLOOD DELIVERY TO MIXING CHAMBER OF A BLOOD TESTING CARTRIDGE

Embodiments of a blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. In some embodiments, the blood coagulation testing system includes a single-use cartridge component configured to measure and mix reagents with blood received from a blood sample reservoir. A mixing chamber in the single-use cartridge includes different reagent beads that, when exposed to a pre-determined volume of blood, dissolve and mix specific reagents with the blood. The assembled blood cartridge further includes configurations that are designed to prevent blood from prematurely mixing with reagent beads in the mixing chamber and to guide blood flow in the mixing chamber to dissolve reagent beads in a desired order. Thus, the mixture obtained from the mixing chamber can be readily utilized to generate results for the blood coagulation testing system. 1. A blood cartridge device having at least one wall , the blood cartridge device comprising:at least one measuring chamber;at least one mixing chamber comprising an entrance, the mixing chamber configured to receive blood from the measuring chamber through the entrance; andat least one blood guide formed on the at least one wall of the blood cartridge device, the blood guide configured to direct blood flow within the mixing chamber.2. The blood cartridge device of claim 1 , wherein the blood guide is formed using one of overmolding claim 1 , molding claim 1 , photo-etching claim 1 , photolithography claim 1 , laser engraving claim 1 , or 3D printing.3. The blood cartridge device of claim 1 , wherein the blood guide is elevated a minimum of 0.5 mm above the wall of the blood cartridge device.4. The blood cartridge device of claim 1 , wherein the blood guide has a minimum width of 0.5 mm.5. The blood cartridge device of claim 1 , wherein the mixing chamber further comprises one or more dissolvable reagent beads claim 1 , and wherein the blood guide ...

SYSTEM AND METHOD FOR SAMPLING HALOSILANES

This disclosure is directed to a system and method relevant to sampling halosilanes or other water-reactive samples. In embodiments, a system for hydrolyzing samples includes a container with a receiving liquid (e.g., an HF solution) contained therein and an actuator coupled with the container. The actuator can be configured to rotate the container, thereby inducing a vortex in the receiving liquid. The system further includes a sample tube configured to direct a halosilane sample into the vortexed receiving liquid. The sample tube can be oriented to release the sample in a flow direction of the vortexed receiving liquid. 1. A system for hydrolyzing samples , comprising:a container with a receiving liquid contained therein;an actuator coupled with the container, the actuator being configured to rotate the container, thereby inducing a vortex in the receiving liquid; anda sample tube configured to direct a sample into the vortexed receiving liquid, wherein the sample tube is oriented to release the sample in a flow direction of the vortexed receiving liquid.2. The system of claim 1 , wherein the sample comprises a halosilane.3. The system of claim 1 , wherein the receiving liquid comprises a hydrofluoric acid solution.4. The system of claim 1 , wherein the sample tube is configured to direct an inert gas into the vortexed receiving liquid prior to introduction of the sample.5. The system of claim 1 , wherein an end of the sample tube that directs the sample into the vortexed receiving liquid is tapered or coupled to a nozzle.6. The system of claim 1 , further comprising a second tube configured to direct an evaporation gas into the container.7. The system of claim 6 , wherein the evaporation gas comprises nitrogen.8. The system of claim 6 , wherein the evaporation gas is heated above an ambient temperature.9. The system of claim 6 , wherein the sample tube and the second tube are parallel to one another.10. The system of claim 6 , wherein the sample tube and the ...

Method for analysing a sample comprising at least a first and a second scale inhibitor

The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration. 1. Method for analysing a sample comprising at least a first and a second scale inhibitor , which scale inhibitors are synthetic organic compounds comprising at least one ionised group , the method comprisingoptionally diluting and/or purifying the sample,allowing the sample interact with a reagent comprising lanthanide(III) ion,exciting the sample at a first excitation wavelength and detecting a sample signal deriving from the lanthanide(III) ion at a signal wavelength by using time-resolved luminescence measurement,determining the total concentration of the first and the second scale inhibitor by using the detected sample signal,determining the concentration of the first scale inhibitor in the sample,determining the concentration of the second scale inhibitor mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.2. Method according to claim 1 , characterised in determining the concentration of the first scale inhibitor by exciting the sample at a second excitation wavelength ...

Methods and devices for producing cellular suspensions from tissue samples

Aspects of the present disclosure include methods of producing a cellular suspension from a tissue sample by applying resonant acoustic energy to a container comprising the tissue sample in a manner sufficient to produce a cellular suspension from the tissue sample. Resonant acoustic mixers and kits for use in producing a cellular suspension from a tissue sample are also provided.

Implement Analyzing Device and Method for Utilizing the Same

An implement analyzing device that is sized for receiving more than one fluid retainer cartridge assembly is disclosed. The implement analyzing device includes a support member, a housing, a cartridge receiver, at least one cartridge heater, an imaging device and an implement analyzing device integrated circuit. 171.-. (canceled)72. A method comprising:receiving, at data processing hardware, image data from an imaging device in communication with the data processing hardware, the imaging device capturing the image data within a field of view directed toward a cartridge receiver;detecting, by the data processing hardware, one or more test strip assays received by the cartridge receiver based on the image data, the test strip assays configured to chemically react with a chemical analyte after contact with a fluid;obtaining, by the data processing hardware, test information associated with each detected test strip assay; and analyze color and/or intensity information within a result region located on the corresponding test strip assay based on the image data received from the imaging device; and', 'determine a test result indicating a presence and/or concentration of the chemical analyte within the fluid based on the analyzed color and/or intensity information., 'for each detected test strip assay, executing, by the data processing hardware, an analysis routine on the corresponding test strip assay based on the corresponding test information, the analysis routine configured to73. The method of claim 72 , wherein the detecting the one or more test strip assays received by the cartridge receiver comprises detecting a plurality of test strip assays retained by two or more fluid retainer cartridge assemblies removably-inserted into the cartridge receiver claim 72 , each of the two or more fluid retainer cartridge assemblies retaining at least one of the detected plurality of test strip assays.74. The method of claim 72 , further comprising claim 72 , after obtaining the ...

METHOD FOR MEASURING AN ABILITY OF HIGH-DENSITY LIPOPROTEIN TO UPTAKE CHOLESTEROL

Provided is a monoclonal antibody or antigen-binding fragment thereof which binds to a peptide consisting of 51st to 110th amino acid sequence or a peptide consisting of 201st to 267th amino acid sequence of an amino acid sequence of SEQ ID NO: 1, and is capable of binding to high-density lipoproteins of (1) to (3) below; 2. The method according to claim 1 , wherein the monoclonal antibody or antigen-binding fragment thereof binds to a peptide consisting of 91st to 110th amino acid sequence of the amino acid sequence of SEQ ID NO: 1 and does not bind to a range of 101st to 160th of the amino acid sequence of SEQ ID NO: 1.3. The method according to claim 1 , wherein the monoclonal antibody or antigen-binding fragment thereof binds to non-denatured high-density lipoprotein present in a sample under non-denatured conditions.4. The method according to claim 1 , wherein the monoclonal antibody or antigen-binding fragment thereof comprises HCDR1 claim 1 , HCDR2 claim 1 , HCDR3 claim 1 , LCDR1 claim 1 , LCDR2 and LCDR3 comprising amino acid sequences that are respectively same as amino acid sequences of HCDR1 claim 1 , HCDR2 claim 1 , HCDR3 claim 1 , LCDR1 claim 1 , LCDR2 and LCDR3 of monoclonal antibody produced from a hybridoma of accession No. NITE BP-02442 or accession No. NITE BP-02443 or its progeny claim 1 , and wherein HCDR represents a heavy chain complementarity determining region and LCDR represents a light chain complementarity determining region.5. The method according to claim 1 , wherein the monoclonal antibody contains a heavy chain variable region and a light chain variable region consisting of amino acid sequences that are respectively same as amino acid sequences of a heavy chain variable region and a light chain variable region of monoclonal antibodies produced from a hybridoma of accession No. NITE BP-02442 or accession No. NITE BP-02443 or its progeny.6. The method according to claim 1 , wherein the monoclonal antibody contains an amino acid sequence ...

MICROFLUIDIC SYSTEM

The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale. 1. (canceled)2. A method for forming and collecting a plurality of droplets , the method comprising:providing a microfluidic device comprising at least a first channel and a second channel intersecting with each other at a junction and a microchannel extending from the junction and having at least one outlet downstream of the junction;providing a detachable holding component comprising a microchannel having an inlet and an outlet, wherein the inlet is detachably coupled to the outlet of the microchannel of the microfluidic device;forming a plurality of droplets in an immiscible carrier fluid within the microfluidic device; andtransferring the plurality of droplets from the microfluidic device to the holding component by flowing the plurality of droplets through the microchannel of the microfluidic device and into the microchannel of the holding component via a suction force applied by a pump operably coupled to the holding component, wherein each droplet is separated from an immediately adjacent droplet within the microchannel of the holding component.3. The method of claim 2 , wherein the pump is operably coupled to the microfluidic device by way of the holding component.4. The method of claim 3 , wherein the pump is coupled to the outlet of the microchannel of the holding component such that claim 3 , upon application of a suction force thereto claim 3 , the suction force is further applied to the microchannel of the microfluidic device.5. The method of claim 2 , wherein the holding component is configured to maintain separation of at least two immediately adjacent droplets of the plurality of droplets upon detachment of the inlet from the microfluidic device.6. The method of claim 2 , wherein the holding component is configured to induce merging of a least two immediately adjacent droplets of the plurality of ...

NO-SPIN CRYOPRESERVATION TECHNIQUE AND RESULTING PRODUCTS

Methods and processes for cryopreservation and direct cell thawing and seeding or suspension after cryopreservation, including methods that eliminate the necessity of post-thaw wash, spin, and frequent practice of performing a cell count. Cell compositions and no-spin cell products produced using the methods are also described. 1. A method of preparing cells for cryopreservation , said method comprising:providing a concentrated cell pellet or cell suspension comprising a first amount of cells dispersed in a suspension medium;providing a freezing solution comprising a cryoprotectant dispersed in medium or carrier solution;mixing said concentrated cell pellet or cell suspension with said freezing solution to yield a cryopreservation mixture; andsubjecting said cryopreservation mixture to cryopreservation to yield a concentrated composition of cryopreserved cells.2. The method of claim 1 , wherein said concentrated cell suspension comprises from about 2 million cells/mL to about 200 million cells/mL of said cell suspension.3. The method of claim 1 , wherein said cryoprotectant is ethylene glycol claim 1 , propylene glycol claim 1 , dimethyl sulfoxide (DMSO) claim 1 , fetal bovine serum (FBS) claim 1 , propanediol claim 1 , glycerol claim 1 , or a mixture of the foregoing.4. The method of claim 3 , wherein said cryoprotectant is DMSO claim 3 , said freezing solution comprising from about 5% to about 20% (v/v) DMSO.5. The method of claim 1 , wherein said concentrated cell suspension and freezing solution are mixed in a range of from about 0.1:1.9 to about 1.9:0.1 by volume.6. The method of claim 1 , further comprising distributing said cryopreservation mixture into aliquots in a cryopreservation container prior to subjecting said cryopreservation mixture to cryopreservation.7. A concentrated composition of cryopreserved cells prepared by:providing a concentrated cell pellet or cell suspension comprising a first amount of cells dispersed in a suspension medium;providing a ...

Fluid transfer device and process of aseptically transferring a fluid

A fluid transfer device comprising a first reservoir ( 1 ) having a predetermined sub-ambient pressure and volume and a presealed opening ( 1 a ), a second reservoir ( 2 ) containing a predetermined volume of a fluid (M) and having a presealed opening ( 2 a ), and a chamber ( 3 ) having an internal space ( 6 ) and an inlet ( 4 ) to the space ( 6 ) adapted to be connected to the opening ( 2 a ) of the second reservoir ( 2 ) and an outlet ( 5 ) from the space ( 6 ) adapted to be connected to the opening ( 1 a ) of the first reservoir ( 1 ).

Microfluidic system for high-throughput, droplet-based single molecule analysis with low reagent consumption

A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region.

CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE

A disposable cartridge can be used for biofluid sample collection, preparation, and mixing with reagents. After sample collection, the cartridge can be inserted into a reader for sample analysis. This system can be used for detecting and measuring analytes, such as drugs, in saliva for example. This is useful for point of test detection of drugs in applications such as workplace drug testing and driving under the influence of drugs testing. 1. A saliva collection system , the system comprising:a collection body;a first swab piston extending distally from the collection body, the first swab piston comprising a first internal channel configured to wick saliva from an open distal end of the first swab piston;a second swab piston extending distally from the collection body, the second swab piston comprising a second internal channel configured to wick saliva from an open distal end of the second swab piston;a diluted sample cavity in fluid connection with a proximal end of the first internal channel; anda cap having a first tube configured to receive the first swab piston and a second tube configured to receive the second channel piston;a dilution buffer within the first tube and covered by a first frangible cover that is configured to be pierced by the first swab piston when the cap is attached to the collection body;a preservation solution within the second tube and covered by a second frangible cover that is configured to be pierced by the second swab piston when the cap is attached to the collection body; anda fastener configured to secure the cap to the collection body.2. The system of claim 1 , wherein the fastener is configured to secure the cap to the collection body when a predetermined amount of force is applied claim 1 , wherein the first swab piston and first tube are configured so that securing the cap to the collection body drives the dilution buffer through the first internal channel to mix and dilute any saliva within the first internal channel and to ...

DEVICES, SYSTEMS AND METHODS FOR SAMPLE PREPARATION

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens. 1. A system configured to assay a sample for the presence of pathogen-identifying material , comprising:i) a device configured to assay a sample for the presence of pathogen-identifying material, said device comprising a housing, and within said housing, a sonicator having a sonicator tip; a vessel holder configured to hold a vessel having a vessel wall; a sample handling system configured to move said vessel within the housing, wherein the vessel is configured to hold said sample for sonication; a solenoid disposed to urge said sonicator tip towards the vessel wall when said solenoid is activated, wherein the sonicator tip is configured to contact the vessel wall effective to transfer ultrasonic energy from said sonicator to the vessel wall upon operation of the sonicator; a spring disposed to as to urge the sonicator tip away from the vessel wall; and a detector andii) a communication assembly configured to communicate with one or more of a user, another device, a laboratory ...

ENDOTOXIN DETECTION DEVICE AND ENDOTOXIN DETECTION METHOD

Provided are a device and a method for rapidly and simply detecting endotoxin without using an expensive reagent. The endotoxin detection device includes: a region containing an electrolyte solution; a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore; a first electrode that is disposed in a first compartment; a second electrode that is disposed in a second compartment and is electrically connected to the first electrode; an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore; an application means that applies voltage between the first electrode and the second electrode; and a monitoring means that monitors current. 1. An endotoxin detection device that does not use LAL reagent , comprising:a region containing an electrolyte solution that is an artificial dialysate or an injection liquid;a partitioning member that partitions the region into two compartments such that the two compartments are in communication via a nanopore;a first electrode that is disposed in a first compartment;a second electrode that is disposed in a second compartment and is electrically connected to the first electrode;an electrolyte solution flow generating means that causes electrolyte solution in the first compartment to move to the second compartment via the nanopore;an application means that applies voltage between the first electrode and the second electrode; anda monitoring means that monitors ion current flowing in the nanopore.2. The endotoxin detection device according to claim 1 , further comprising an agitation means in proximity to the first compartment.3. The endotoxin detection device according to claim 1 , wherein the electrolyte solution flow generating means is a means of generating electroosmotic flow.4. The endotoxin detection device according to claim 1 , wherein a fixed charge is present ...

BIOLOGICAL FLUIDS

The present disclosure is drawn to a biological fluid, including water, from 0.05 wt % to 3 wt % protein having an acidic isoelectric point (pI) less than about 6.5, and from 0.5 wt % to 20 wt % ionic protein stabilizer system. The ionic protein stabilizer system can include a buffer pair of a weak acid and a weak base, and a lyotropic series ionic compound. 1. A biological fluid , comprising:water;from 0.05 wt % to 3 wt % protein having an acidic isoelectric point (pI) less than about 6.5; and a buffer pair of a weak acid and a weak base, and', 'a lyotropic series ionic compound., 'from 0.5 wt % to 20 wt % ionic protein stabilizer system, wherein the ionic protein stabilizer system includes2. The biological fluid of claim 1 , wherein the protein and the ionic protein stabilizer system is present in the biological fluid at a weight ratio from 1:25 to 1:1.3. The biological fluid of claim 1 , wherein a concentration of the buffer pair and a weight ratio of the weak acid to the weak base contributes to bringing the biological fluid to within 1 pH of the isoelectric point of the protein.4. The biological fluid of claim 1 , wherein a concentration of the buffer pair and a weight ratio of the weak acid to the weak base contributes to bringing the biological fluid to within 0.5 pH of the isoelectric point of the protein.5. The biological fluid of claim 1 , wherein the buffer pair includes: monobasic sodium phosphate and dibasic sodium phosphate claim 1 , monobasic potassium phosphate and dibasic potassium phosphate claim 1 , citric acid and dibasic sodium phosphate claim 1 , citric acid and dibasic potassium phosphate claim 1 , citric acid and sodium citrate claim 1 , citric acid and potassium citrate claim 1 , acetic acid and sodium acetate claim 1 , acetic acid and potassium acetate claim 1 , ammonium chloride and ammonium hydroxide claim 1 , thiocyanic acid and thiocyanate claim 1 , or ammonium sulfate and trimethylamine n-oxide.6. The biological fluid of claim 1 , ...

DEVELOPMENT OF DRY-DEPOSIT TRACE EXPLOSIVES DETECTION TEST STANDARDS, SOLUTIONS AND METHODS FOR DEPOSITION

Various embodiments of the present invention are directed towards a system and method to dispense an explosive compound onto a substrate. An example device includes a solvent having the explosive compound dissolved in the solvent to form a sample. A delivery mechanism dispenses the sample in a dispersed manner to sufficiently vaporize the solvent to prevent wicking while dispersing a residue of the explosive compound on the substrate to enable detection by explosive detection tools. 1. A device to dispense an explosive compound onto a substrate , comprising:a solvent having the explosive compound dissolved in the solvent to form a sample;a delivery mechanism to dispense the sample in a dispersed manner to sufficiently vaporize the solvent to prevent wicking while simultaneously allowing a residue of the explosive compound to be dispersed on the substrate to enable detection by explosive detection tools.2. The device of claim 1 , wherein the delivery mechanism dispenses the sample in a manner to dry-apply trace amounts of the explosive compound onto the substrate as the residue.3. The device of claim 1 , wherein the residue of the explosive compound includes particles having an average particle size of approximately six microns.4. The device of claim 1 , wherein the solvent comprises hydrofluoroalkane (HFA).5. The device of claim 4 , wherein the solvent comprises HFA 134a or HFA 227.6. The device of claim 1 , wherein the solvent comprises dimethyl ether (DME).7. The device of claim 1 , wherein the solvent comprises a first solvent claim 1 , to dissolve the explosive compound corresponding to a first solubility and to serve as a propellant for the delivery mechanism claim 1 , and a second solvent that claim 1 , in combination with the first solvent claim 1 , is to dissolve the explosive compound corresponding to a second solubility greater than the first solubility.8. The device of claim 7 , wherein the first solubility is less than a threshold solubility to enable ...

PRETREATMENT METHOD AND APPARATUS

There is provided a method for performing a pretreatment on an unknown sample including: preparing a plurality of different types of first solutions; adding an unknown sample to the plurality of first solutions and determining whether or not the unknown sample is dissolved; selecting one among the plurality of first solutions in which the unknown sample is dissolved; preparing a plurality of second solution by differentiating concentrations of the selected solution; adding an unknown sample to the second solution and determining whether or not the unknown sample is dissolved; selecting a solution having the lowest concentration in which the unknown sample can be dissolved from among the second solutions; and dissolving the unknown sample by using the solution having the lowest concentration. 1. A method for performing a pretreatment on an unknown sample , the method comprising:preparing a plurality of different types of first solutions;adding an unknown sample to the plurality of first solutions and determining whether or not the unknown sample is dissolved;selecting one among the plurality of first solutions in which the unknown sample is dissolved;preparing a plurality of second solutions by differentiating concentrations of the selected solution;adding an unknown sample to the second solution and determining whether or not the unknown sample is dissolved;selecting a solution having the lowest concentration in which the unknown sample can be dissolved from among the second solutions; anddissolving the unknown sample by using the solution having the lowest concentration.2. The method of claim 1 , wherein the plurality of first solutions are aqueous solutions including one or more acids claim 1 , or pure solutions.3. The method of claim 1 , wherein the determining of whether or not the unknown sample is dissolved is performed by measuring turbidity.4. The method of claim 3 , wherein the turbidity is measured by measuring intensity of transmitted light or scattered ...

System and Method for Charging Fluids

Devices, systems, and methods for charging fluids are disclosed. The charging of fluids improves the mixing of fluids in microfluidic systems. The charging is performed by producing an ion field ( 50 ) between an ionizing electrode ( 20 ) and an opposed ground electrode ( 30 ). A fluid-containing vessel ( 40 ) is positioned between the opposed electrodes and the ion field charges the fluid ( 41 ) in the vessel.

SYSTEMS, METHODS, AND APPARATUS FOR SAMPLE DISPERSION

Some embodiments comprise a sample dispersion system including a sample container having a housing with two or more orifices to control the introduction of said fluid and/or the passage of carrier solution into the sample container and/or the passage of fluid from the sample container. The carrier fluid may be moving in a flow from an inlet orifice to an outlet orifice in order to disperse the sample fluid in flow. The sample container may be configured to rotate about an axis substantially parallel to the fluid flow. The sample container may be configured to rotate (or tilt) about an axis substantially perpendicular to the fluid flow. The sample container may alternate from a first position to a second position at controllable rate, frequency, and/or direction. 1. A sample dispersion system for an analytical device , comprising:a movable sample container configured to completely enclose a fluid including a plurality of sample particles, the sample container having a housing with two or more orifices for the introduction of said fluid and/or the passage of carrier solution into the sample container and/or the passage of fluid from the sample container, wherein said fluid and carrier solution are flowable from an inlet orifice to an outlet orifice and the orifices are connected to valves or otherwise configured to halt fluid flow in a closed state and to allow fluid flow in an open state; anda carrier reservoir in fluid communication with the sample container, wherein the carrier reservoir contains a liquid carrier solution for moving a plurality of sample particles in liquid flow,wherein said fluid including a plurality of sample particles is introduced via an orifice into the sample container; liquid carrier solution is introduced via an inlet orifice into the sample container from the carrier reservoir; the sample container containing said fluid is moved about an axis in relation to the flow of carrier solution through the sample container, said movement ...

Testing module and method for testing test sample

A testing module is provided. The testing module includes a carrier, a block member, and a sampling assembly. A flow path connects a storage chamber to a mixing chamber to guide the flow of a fluid. The block member is formed in the flow path to block the fluid from flowing from the storage chamber to the mixing chamber before the connection of the sampling assembly. When the sampling assembly which contains a test sample is connected to the carrier, the fluid mixes with the test sample and flows to the mixing chamber.

Apparatus and Process for Producing Patterned, Micron and Nanometer Size Reaction and Mixing Zones for Fluids Deposited on Smooth, Rough and Porous Surfaces and Applications of that Process

Process for producing patterned, micron and nanometer scale features by reacting or mixing in the small volumes at the intersections of coalescing drops, at the fronts of colliding thin films in front of spreading drops, or in the pore space of a porous medium under the drop. The process can be implemented on smooth, rough or porous surfaces and embodiments include multiplexed, single drop chemical or biochemical sensors and encryption of information of a printed page.

MUCOLYTIC TABLET FOR A SAMPLE COLLECTION DEVICE

The present disclosure relates to a mucolytic tablet for a sample collection device that causes mucolysis of biological samples collected in the sample collection device. The mucolytic tablet includes N-acetyl L-cysteine (NALC), a pharmaceutically active mucolytic agent that reduces the viscosity of mucus containing biological samples. The mucolytic tablet also includes one or more chelating agents, water-soluble anti-adherent/s, and at least one buffering agent. 1. A mucolytic tablet for a sample collection device , comprising:(i) 15% to 65% by weight of N-acetyl L-cysteine (NALC);(ii) 6% to 30% by weight of a buffering agent;(iii) 10% to 14% by weight of a water soluble anti-adherent; and(iv) 2% to 10% by weight of at least one chelating and lubricating agent,wherein the mucolytic tablet solubilizes in a resuspension buffer.2. The mucolytic tablet of claim 1 , wherein the mucolytic tablet includes 55% to 65% by weight of NALC.3. The mucolytic tablet of claim 1 , wherein the buffering agent is dipotassium hydrogen phosphate.4. The mucolytic tablet of claim 1 , wherein the water soluble anti-adherent is L-Leucine.5. The mucolytic tablet of claim 1 , wherein the at least one chelating and lubricating agent is polyethylene glycol.6. The mucolytic tablet of claim 1 , wherein the at least one chelating agent is sodium citrate.7. The mucolytic tablet of claim 1 , wherein the mucolytic tablet is prepared by applying a compression force between 3.5-4.5 pascal.8. The mucolytic tablet of claim 1 , wherein the resuspension buffer includes 60 mM to 67 mM phosphates claim 1 , and 56-60 mM sodium citrate9. The mucolytic tablet of claim 8 , wherein the phosphates of the resuspension buffer are from 30-36 mM disodium hydrogen phosphate and 30-36 mM dipotassium hydrogen phosphate.10. The mucolytic tablet of claim 1 , wherein a weight of the mucolytic tablet is between 0.045-0.055 grams.11. The mucolytic tablet of claim 1 , wherein a time for dissolving the mucolytic tablet in 3-6 ...

Sensor Operable to Measure Ozone Concentration and a Method for Using a Sensor

In an embodiment a sensor includes an outer housing, an inner housing disposed within an interior of the outer housing or connected to the interior of the outer housing, an ozone sensing component disposed within an interior of the inner housing, an ozone modifying component disposed within the interior of the outer housing, a substrate on which the ozone sensing component and the ozone modifying component are disposed, a first inlet integrated into the outer housing, the first inlet being configured to conduct ambient gaseous matter from an outside of the outer housing into the interior of the outer housing and a second inlet integrated into the inner housing, the second inlet being configured to conduct the gaseous matter from the interior of the outer housing into the interior of the inner housing and adjacent to the ozone sensing component, wherein the ozone sensing component is configured to generate a sensing component signal corresponding to an ozone concentration of the gaseous matter within the interior of the inner housing, and wherein the ozone modifying component is configured to alter the ozone concentration of the gaseous matter within the interior of the outer housing. 114.-. (canceled)15. A sensor comprising:an outer housing;an inner housing disposed within an interior of the outer housing or connected to the interior of the outer housing;an ozone sensing component disposed within an interior of the inner housing;an ozone modifying component disposed within the interior of the outer housing;a substrate on which the ozone sensing component and the ozone modifying component are disposed;a first inlet integrated into the outer housing, the first inlet being configured to conduct ambient gaseous matter from an outside of the outer housing into the interior of the outer housing; anda second inlet integrated into the inner housing, the second inlet being configured to conduct the gaseous matter from the interior of the outer housing into the interior of ...

DEVICE AND METHOD FOR MEASUREMENT OF SARS-CoV-2 SPECIFIC ANTIGEN IN A BIOLOGICAL SAMPLE

A device for retaining a biological sample, for measuring a concentration of a SARS-CoV2 specific antigen, with SARS-CoV2 antigen-specific and electrochemically active immunoreceptor that is conjugated with an electrochemically active substance and optionally including an electrode reactivity enhancement agent and antibody stabilization agent. The immunoreceptor is configured to be in chemical contact with electrodes and a biological sample with SARS-CoV2 specific antigen of the device. The present invention also provides a device holder for holding the device of the present invention and a point-of-care biosensor. A method for measuring a concentration of SARS-CoV2 specific antigen from a reduced volume of biological sample is also provided in the presence of the antigen-specific and electrochemically active immunoreceptor, by measuring a peak value of redox current of the SARS-CoV2 antigen-specific and electrochemically active immunoreceptor and determining a concentration of SARS-CoV2 specific antigen in the biological sample, by linearly matching with a corresponding reference redox current. 1100. A device for collecting and retaining a biological sample , for measuring a concentration of a SARS-CoV2 specific antigen in a biological sample , comprising:{'b': ['102', '102', '101'], 'i': ['a', 'b'], '#text': '(i) at least a pair of conductive tracks , are disposed on a substrate ;'}{'b': ['103', '103', '102', '102'], 'i': ['a', 'b', 'a', 'b'], '#text': '(ii) at least a pair of electrodes , are connected to the at least pair of conductive tracks , ; and'}{'b': ['105', '103', '103'], 'i': ['a', 'b'], '#text': '(iii) a SARS-CoV2 antigen-specific and electrochemically active immunoreceptor that is conjugated with at least an electrochemically active substance, is configured to be in chemical contact with the at least pair of electrodes , and the biological sample.'}2100. The device as claimed in claim 1 , wherein the material for the substrate is a rigid material ...

High Throughput Methods for Screening Chemical Reactions Using Reagent-Coated Bulking Agents

Systems, methods, and compositions for high throughput screening of micro-scale chemical reactions are disclosed. In particular, systems, methods, and compositions for handling small amounts of solid reagent are disclosed. For example, mechanical mixing is employed to obtain reagent-coated bulking agents that can be used, inter alia, in high throughput methods for screening micro-scale chemical reactions. 1. A solid substrate comprising an outer surface and at least one reagent for chemical synthesis attached to the outer surface , wherein the reagent for chemical synthesis is attached to the outer surface by an application of mechanical energy to a mixture comprising the reagent for chemical synthesis and the solid substrate.2. The solid substrate of claim 1 , wherein the solid substrate is a glass bead or a polystyrene bead.3. The solid substrate of claim 1 , wherein the solid substrate is a bead having a diameter from about 150 microns to about 400 microns.4. The solid substrate of any one of the preceding claims claim 1 , wherein the reagent for chemical synthesis is selected from the group consisting of a reactant claim 1 , a transition metal source claim 1 , a coupling ligand claim 1 , a base claim 1 , and combinations thereof.5. The solid substrate of any one of the preceding claims claim 1 , wherein the reagent for chemical synthesis is present in an amount from about 1% to about 20% (w/w).6. A kit comprising a solid substrate of .7. A method for making a reagent-coated bulking agent comprising the steps of:(a) combining a reagent and a bulking agent to form a mixture; and(b) applying mechanical energy to the mixture.8. The method of claim 7 , wherein the mechanical energy is applied using an acoustic mixer.9. The method of claim 7 , wherein the bulking agent is a glass bead or a polystyrene bead.10. The method of claim 7 , wherein the reagent is selected from the group consisting of a reactant claim 7 , a transition metal source claim 7 , a coupling ligand ...

BALLAST WATER MONITORING DEVICE

A ballast water monitoring device and a method for detecting live phytoplankton are disclosed. The device comprises a chamber for receiving a sample, at least one light source to emit light towards the sample, a light detector to receive light from the sample and generate a light signal, and a controller. The controller is configured to control the at least one light source to emit a single pulse of light, calculate the variable fluorescence [Fv] of the sample in response to the pulse of light, at time intervals less than the duration of the pulse of light, compare the calculated variable fluorescence to a predetermined reference limit, and perform an action if the calculated variable fluorescence is greater than the predetermined reference limit. 1. A ballast water monitoring device for detecting live phytoplankton , the device comprising:a chamber for receiving a sample;at least one light source to emit light towards the sample;a light detector to receive light from the sample and generate a light signal; and control the at least one light source to emit a single pulse of light,', {'sub': 'v', 'calculate the variable fluorescence [F] of the sample in response to the pulse of light, at time intervals less than the duration of the pulse of light,'}, 'compare the calculated variable fluorescence to a predetermined reference limit, and', 'perform an action if the calculated variable fluorescence is greater than the predetermined reference limit., 'a controller configured to2. The ballast water monitoring device of claim 1 , comprising a plurality of light sources claim 1 , optionally wherein each light source is associated with a different wavelength.3. The ballast water monitoring device of claim 1 , further comprising a means for indicating to the user that the variable fluorescence exceeds the predetermined reference limit claim 1 , wherein performing an action comprises activating the indicating means.4. (canceled)5. (canceled)6. The ballast water monitoring ...

SEMI-DRY TYPE METHOD FOR AUTOMATICALLY SAMPLING PM2.5 PARTICLES

The present invention discloses a semi-dry type method for automatically sampling PM2.5 particles. The method an aerosol sample in a dry mode and extracts it in a wet mode to prevent sampling artifacts. In the dry mode, a first stage utilizes carbon brushes as discharge electrodes to charge aerosol particles which are then collected on the cylinder wall by the electric field setup between the high-voltage central metal rod and the grounded cylinder in the second stage. In the wet mode, DI water is injected into the EPILS in a pulsation manner by opening and closing solenoid valves intermittently, which dislodges aerosol particles deposited on the cylinder wall effectively to become a liquid aerosol sample. The liquid aerosol sample is then analyzed for chemical compositions automatically. 1. A semi-dry type method for automatically sampling PMparticles which utilizes an automatic sampling system , the automatic sampling system comprising a main controller , a first high voltage power supply , a second high voltage power supply , a mass flow controller , a syringe pump assembly , a water sample analyzer and a semi-dry type electrostatic sampler , the main controller being signally connected to the first high voltage power supply , the second high voltage power supply , the mass flow controller and the syringe pump assembly , the syringe pump assembly comprising at least one water injecting syringe , a sampling syringe and a plurality of injecting pumps , the injecting pumps being adapted to pump water into the water injecting syringes and the sampling syringe and to injecting water from the water injecting syringes and the sampling syringe , respectively; the semi-dry type electrostatic sampler comprising:a main body, having an aerosol inlet on a top side, an aerosol outlet on a bottom side, a water outlet on the bottom side, a cylinder wall and at least one water injecting opening formed on the cylinder wall, the cylinder wall defining a particle charging area ...

FLUID PROCESSING MICRO-FEATURE DEVICES AND METHODS

The present description provides, in some embodiments, an apparatus for mixing a fluid in a circuit having an inlet channel defining a flow path for a fluid including particulate matter, a first reagent channel in fluid communication with the inlet channel and defining a first reagent flow path for a first reagent, the inlet channel and first reagent channel configured to shear the fluid entering the first reagent channel from the inlet channel at a first junction, a shearing channel in fluid communication with the inlet channel and first reagent channel at the first junction, and a diffusion channel in fluid communication with the shearing channel at a second junction, the sheared fluid collectable into the diffusion channel such that the fluid is compressed at least in part by the first reagent to have a thickness close to a diameter of the particulate matter in the fluid. 1. A method of mixing a fluid , comprising:injecting a fluid containing particulate matter into an inlet channel of a circuit;injecting a reagent into first and second reagent channels, the first and second reagent channels defining first and second reagent flow paths;shearing the fluid by the reagent at a first junction at which the fluid inlet channel and the first reagent channel merge into a shearing channel, a top wall of the inlet channel and a top wall of the shearing channel coplanar proximate the first junction; andcompressing the sheared fluid by the reagent at a second junction at which the shearing channel and second reagent channel merge into a diffusion channel,wherein the compressed fluid has a thickness less than a diameter of the particulate matter in the fluid, and the diffusion channel provides a length for at least a portion of the particulate matter extending into the reagent to react with the reagent.2. The method of claim 1 , wherein the compressed fluid has a thickness less than 8 μm.3. The method of claim 1 , wherein the fluid exhibits a flow rate (V) through the ...

BIO/CHEMICAL MATERIAL EXTRACTION AND ASSAY

Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip. 1. A device , comprising: the first and second plates are movable relative to each other into an open configuration and a closed configuration,', 'each of the first and second plates respectively comprise an inner surface that has a sample contact area for contacting a fluid sample, and', 'at least one of the plates is flexible;, 'a first plate and a second plate, whereinspacers that are fixed on at least one of the first and second plates and have a predetermined substantially uniform height; anda first and a second electrode fixed to at least one of the first and second plates;wherein in the open configuration, the first and second plates are partially or entirely separated apart to enable the fluid sample to be deposited on at least one of the first and second plates, wherein a spacing between the first and second plates is not regulated by the spacers; andwherein in the closed configuration, which is configured after the fluid sample is deposited on at least one of the first and second plates in the open configuration, at least part of the fluid sample is compressed by the first and second plates into a layer of substantially uniform thickness and is substantially stagnant relative to the first and second plates, wherein the uniform thickness of the layer is confined by the inner surfaces of the first ...

CONTAINER ASSEMBLY AND ASSOCIATED METHOD

Container assembly including a container for storing a tissue sample and a cover adapted to engage with the container. The cover includes: a top member having a receptacle, a seal for sealing off the receptacle, a puncturing member for breaking the seal by displacement of the puncturing member. The container assembly has a first and a second position, wherein in the first position the container is isolated from the receptacle, and in the second position fluid communication is provided between the receptacle and the container. The container assembly includes a separator positioned between the seal and the bottom of the container, and the separator is provided with at least one aperture adapted to provide a fluid passage between the receptacle and the container. 1. A container assembly comprising:a container for storing a tissue sample; said container comprising a bottom;a cover adapted to engage with said container, said cover comprising:a top member comprising a receptacle, said receptacle being adapted to contain a preserving agent;a seal for sealing off said receptacle;a puncturing member for breaking said seal by displacement of said puncturing member;where the container assembly has a first and a second position, wherein in the first position the container is isolated from the receptacle, and in the second position fluid communication is provided between the receptacle and the container, characterized wherein the container assembly comprises a separator positioned between the seal and the bottom of the container, and the separator is provided with at least one aperture adapted to provide a fluid passage between the receptacle and the container.230. The container assembly according to claim 1 , further comprising a space between the separator and the seal claim 1 , the separator being provided with a conduit () adapted to provide a fluid passage between the space and the container.3. The container assembly according to claim 2 , wherein the conduit has an opening ...

SPECIMEN DELIVERY APPARATUS

A specimen delivery apparatus includes a housing having a backplane. The backplane includes at least one fluid communication port. The housing has an open state and a closed state. A midplane has a cavity for holding a sample. The midplane is sealed within the housing when the housing is in the closed state. A first actuator is disposed to move fluid within the housing when the housing is in a closed state and the first bulb is actuated. Various embodiments provide for caching of the fluid as well as staging to permit further preparation of the specimen prior to delivery. Various features roil the fluid to assist in extraction, mixing, and transport of the sample with the fluid. A destructible seal prevents fluid communication through the fluid communication port while the seal is intact. Communication of fluid through the fluid communication port is enabled only when the destructible seal is not intact. 1. A specimen delivery apparatus comprising:a housing having an open state and a closed state;a midplane having a cavity for holding a sample, wherein the midplane is sealed within the housing when the housing is in the closed state;a fluid transport path having a roiling feature to roil fluid propelled through the fluid transport path; anda first bulb disposed to move fluid within the apparatus through at least a portion of the fluid transport path that includes the roiling feature when the housing is in a closed state and the first bulb is actuated.2. The apparatus of claim 1 , further comprising a backplane and at least one attachment point for mechanically coupling the apparatus to another apparatus claim 1 ,wherein the backplane includes at least one fluid communication port,wherein the apparatus further comprises a destructible seal preventing fluid communication through the fluid communication port while the seal is intact,wherein actuation of the first bulb communicates fluid through the fluid communication port when the destructible seal is not intact, ...

SAMPLE COLLECTION KIT INCLUDING TWIST AND TEAR SOLUTION CAP

A biological sample collection device can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The sample collection chamber can also include elongate ridges disposed along and projecting inwardly from an interior portion thereof. The sample collection vessel can also include a connection member disposed on an exterior portion and a fluid reservoir. The fluid reservoir can include a reagent chamber having an open end and a closed end with an elongate member disposed at the closed end that is sized and shaped to engage the elongate ridges of the sample collection vessel when arranged within the fluid reservoir. The sample collection vessel can also include a sealing cap having internal threads for engaging external threads of the fluid reservoir and a complementary connection member to couple the sample collection vessel and the sealing cap. 1. A biological sample collection system , comprising: a sample collection chamber, the sample collection chamber having an opening that is configured to receive the biological sample into the sample collection chamber;', 'one or more ridges disposed along and projecting inwardly from an interior portion of the sample collection chamber; and', 'a connection member disposed on an exterior portion of the sample collection vessel;, 'a sample collection vessel, the sample collection vessel comprising a reagent chamber, the reagent chamber having an open end and a closed end;', 'an elongate member disposed at the closed end of the reagent chamber, the elongate member sized and shaped to engage at least one of the one or more ridges of the sample collection vessel when positioned within the sample collection chamber; and', 'external threads disposed on an exterior portion of the fluid reservoir; and, 'a fluid reservoir, the fluid reservoir comprising internal threads configured to engage the external threads of the fluid ...

SYSTEMS AND METHODS FOR SAMPLE PREPARATION USING SONICATION

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens. 120-. (canceled)21. A device configured to assay a sample for presence of pathogen-identifying material , said device comprising:a sonicator; a detector, a sample handling system, a vessel holder configured to hold a vessel, and a device to urge the sonicator apart from the vessel;wherein said vessel holder has a port to allow a sonicator tip of the sonicator to extend into the vessel holder and contact the vessel, wherein the vessel holder and the sonicator tip are movable relative to each other.22. The device of claim 21 , wherein said sonicator tip is configured to contact a vessel wall effective to transfer ultrasonic energy from said sonicator to said vessel wall upon operation of said sonicator.23. The device of claim 21 , wherein said sonicator tip is configured to contact a vessel wall effective to transfer ultrasonic energy from said sonicator to said vessel wall upon operation of said sonicator claim 21 , and optionally wherein the device is configured to apply force ...

ROTATABLE CARTRIDGE FOR PROCESSING AND ANALYZING A BIOLOGICAL SAMPLE

An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample. 1. A method of repeatedly dispensing measured amounts of a fluid using a cartridge , wherein the cartridge is operable for being spun around a rotational axis , wherein the cartridge comprises:a metering chamber, wherein the metering chamber is operable for causing fluid to fill the metering chamber using capillary action, wherein the metering chamber has side wall regions and a central region, wherein the side wall regions are narrower than the central region in a cross sectional view of the metering chamber, wherein capillary action next to the side wall regions of the metering chamber is greater than in the central region of the metering chamber; anda duct connected to the metering chamber, wherein the duct comprises a duct entrance and a duct exit in the metering chamber, the duct exit being closer to the rotational axis than the duct entrance, wherein the duct is operable for causing fluid to flow to the metering chamber using capillary action, wherein the method comprises:decreasing a rotational rate of the ...

Devices and Methods for Biological Assay Sample Preparation and Delivery

Devices and methods for preparing and delivering biological assay samples are provided herein. Components of such devices include a sample receiving module within which a biological assay sample can be prepared and a cap, which when operatively coupled with the sample receiving module, pressurizes the module. These devices can be employed for subsequently delivering a biological assay sample. 1. A biological assay sample preparation device , the device comprising:a. a sample receiving module comprising an outer body forming a first chamber, an inner body forming a second chamber, a preparation solution, and a first attachment element; andb. a cap removably coupleable to the sample receiving module and comprising:i. a pressurizing component; andii. a second attachment element operatively coupleable with the first attachment element,wherein the pressurizing component extends into and pressurizes the sample receiving module upon operative coupling of the first attachment element to the second attachment elementwherein the outer body comprises a piercing member, wherein the inner body comprises a breakable seal and is movable within the outer body, andwherein operatively coupling the first attachment element to the second attachment element comprises moving the inner body within the outer body to break the breakable seal and place the first and second chambers in fluidic communication.2. The device according to claim 1 , wherein the fluid container is adapted to receive one or more portions of a sample.3. The device according to claim 1 , wherein the preparation solution is a nucleic acid amplification preparation solution.4. The device according to claim 1 , wherein the cap comprises a receptacle configured to receive an end of the sample receiving module therein when the cap is coupled to the sample receiving module.5. The device according to claim 4 , wherein the pressurizing component is disposed within the receptacle or integral with the cap.6. (canceled)7. The ...

ON-SITE DETECTION OF PARASITIC INFECTION OF MAMMALS

A portable kit for generating a digital image of a faecal sample suitable for microscopic analysis, comprises a faecal sample preparation device configured to receive a faecal sample and a faecal flotation fluid, filter a suspension comprising the faecal sample and the faecal flotation fluid to provide a filtrate, a translucent faecal sample support, and a portable digital imaging module. The portable digital imaging module comprises a housing, a camera/microscopic lens assembly configured to generate a digital image of the faecal sample on the sample support, an illumination system, a seat for receiving the faecal sample support disposed between the camera/microscopic lens assembly and illumination system, a memory for storing the digital image, a communication system for communicating the digital image to an off-site image processing module via a communications network, and a battery operatively connected to the camera and microscopic lens assembly, memory and communication system. 1. A system for on-site determination of a parasitic infection characteristic of a non-human mammal , comprising:a portable faecal sample preparation device configured for use on-site to receive faecal matter from the mammal and a faecal flotation fluid, mix the faecal matter and faecal flotation fluid to provide a suspension, and filter the suspension to provide a filtrate, in which the filtrate is the faecal sample;a translucent faecal sample support;a portable digital imaging module adapted to generate a digital image of a faecal sample on the sample support and communicate the digital image via a wireless communications network by detachable engagement with a mobile communications device in a sample support imaging position, in which the digital image of the faecal sample on the sample support is generated by a camera of the mobile communications device and communicated to the off-site digital image analysis module via the mobile communications device;an off-site digital image ...

METHOD AND DEVICE FOR THE MANIPULATION OF MICROCARRIERS FOR AN IDENTIFICATION PURPOSE

A method and apparatus for the manipulation for an identification purpose of a microcarrier. The method comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step. The apparatus comprising means for identification purposes such as a microscope or labelling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers. 1. A method for manipulation of a microcarrier for the purpose of identifying the microcarrier , said method comprising the steps of:a detection step for detecting an encoded microcarrier, wherein the encoded microcarrier includes a code written thereon; and distributing a plurality of microcarriers, that includes said encoded microcarrier, in a one-layer system which results in a plane configuration having two dimensions (X, Y), and', 'restricting rotational movement of the plurality of microcarriers, wherein the plurality of microcarriers have an ellipsoidal or cylindrical shape and wherein the positioning and orientation step results from the ellipsoidal or cylindrical shape of the plurality of microcarriers., 'a positioning and orientation step prior to or during the detection step, wherein said positioning and orientation step comprises2. The method according to claim 1 , wherein the step of distributing the plurality of microcarriers in the one-layer system results in a line configuration.3. The method according to claim 1 , wherein said encoded microcarrier is encoded by a code written thereon by exposure to a high spatial resolution light source.4. The method according to claim 1 , wherein the method further comprises:(i) encoding said encoded microcarrier by writing a code thereon, and(ii) allowing a target-analyte reaction on or in said encoded microcarrier.5. The method according to claim 4 , wherein step (ii) precedes step (i).6. The method according to claim 4 , ...

HIGH-THROUGHPUT SAMPLE PROCESSING SYSTEMS AND METHODS OF USE

Disclosed herein are high-throughput sample processing systems and waste management systems, and methods of using the same. 1. A high throughput sample processing system comprising:a sample dispensing device for drawing a plurality of samples from a plurality of sample containers and for dispensing each sample into a well of a sample processing plate comprising a plurality of wells, wherein each sample is dispensed into a different well;a contactless fluid dispensing device for dispensing fluids into the plurality of wells of the sample processing plate;a plurality of contactless liquid level sensors for detecting the liquid level in each of the plurality of wells of the sample processing plate;a plurality of aspirators for removing fluids from the plurality of wells of the sample processing plate;a plurality of contactless treatment stations for treating a plurality of sample processing plates simultaneously;a waste management system for managing fluids removed from the plurality of wells; anda control system for controlling the processing of a plurality of plates within the high throughput sample processing system simultaneously.2. The high throughput sample processing system of claim 1 , wherein the control system dynamically controls the processing of a plate depending upon the location or status of other plates in the system.3. The high throughput sample processing system of claim 1 , further comprising a plate loading device for automatically loading additional plates into the sample dispensing device.4. The high throughput sample processing system of claim 1 , wherein the sample dispensing device comprises a plurality of syringe based pipettes.5. The high throughput sample processing system of claim 4 , wherein the pipettes comprise reusable pipette tips.6. The high throughput sample processing system of claim 5 , wherein the sample dispensing device comprises a washing station for automatically washing the reusable pipette tips.7. The high throughput sample ...

Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes

Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.