Method for particle analysis and method for particle production

The method for particle analysis includes a first magnetic susceptibility measurement step S4 of measuring a volume magnetic susceptibility of each of first particles p1; an encapsulation treatment step S5 of performing an encapsulation treatment so that the first particles p1 encapsulate an encapsulation target component pt smaller than the first particles p1; a second magnetic susceptibility measurement step S8 of measuring a volume magnetic susceptibility of each of second particles p2 as an analysis target that are the first particles p1 after the encapsulation treatment; and a step S9 of analyzing whether or not the encapsulation target component pt is encapsulated in the second particles p2 based on a result of measurement in the first magnetic susceptibility measurement step S4 and a result of measurement in the second magnetic susceptibility measurement step S8.

Quadrature phase analysis light scattering for electrophoresis and zeta potential measurements

Stationary devices employing quadrature phase analysis light scattering are provided, to aid in the determination of the magnitude and polarity of electrophoretic mobility and zeta potential of particles in colloids. The devices use an optical quadrature interferometer with an electrophoresis sample chamber containing sample particles undergoing electrophoresis, the optical quadrature interferometer being configured to generate a quadrature signal. The phase of the quadrature signal may be analyzed at the frequency of the sample chamber electric field to estimate displacements and directions of the particles. The estimates can be used to determine a central value of the magnitude of the electrophoretic mobility, as well as its polarity. Particles having low electrophoretic mobility, or that may be adversely affected by high electric fields, can be analyzed, and constraints on vibration and light source coherence length may be relaxed. A phase modulator or frequency shifter is not required ...

Multiple Flow Channel Particle Analysis System

A microfluidic multiple channel particle analysis system ( 1 ) which allows particles ( 2 ) from a plurality of particle sources ( 3 ) to be independently simultaneously entrained in a corresponding plurality of fluid streams ( 4 ) for analysis and sorting into particle subpopulations ( 5 ) based upon one or more particle characteristics ( 6 ).

Information processing apparatus and method and system for particle simulation

Technique includes acquiring first contact data of first time, associated with first particle in first region; calculating first position data on particles in the first region at second time, and receiving second position data on particles in second region at the second time; detecting second particle being in contact with the first particle and in the first region at the first time and being in the first region at the second time; copying, when the first and second particles are in contact at the second time, displacement of the second particle from the first contact data to second contact data of the second time; detecting third particle being in the first or second region at the second time and in contact with the first particle; and copying, when the third particle is listed in the first contact data, displacement of the third particle to the second contact data therefrom.

Method and system to evaluate embryos

A system to evaluate an embryo is provided. The system includes a measurement chamber having a bottom end. The measurement chamber is configured to receive an embryo such that the embryo descends towards the bottom end, and a culture medium is disposed within the measurement chamber. At least one sensor is configured to assess the embryo descending towards the bottom end and output a data signal representative of at least one characteristic of the embryo descending through at least a portion of the measurement chamber. A processor receives the data signal from the at least one sensor and determines one or more embryo properties based on the at least one characteristic.

Multi-view analysis in automated testing apparatus

Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device may include a camera arranged to capture a plurality of images, including a first image and a second image, of the holding area. The device may include a positioning mechanism operable to adjust a relative location of the carrier to the camera. A processor in the device may utilize the camera module to: identify an edge of the first image; cause the positioning mechanism to adjust the relative location of the carrier to the camera in a manner such that, when the camera takes the second image, an edge of the second image aligns with the identified edge of the first image; and perform a set of analytic processes on a combined image from the first and second images.

Blood fluidity measurement apparatus and blood fluidity measurement method

Deformability of blood cells is quantified in a short time. A blood fluidity measurement apparatus is provided with a TV camera which photographs a stream of blood in either two areas of the internal area, entrance area, and exit area of a gate, an image processing part which calculates the velocity of the blood cells contained in the blood from the image taken by the TV camera, and a deformability calculation means which calculates the deformability of the blood cells a blood fluidity from the velocity.

Magnetophorisis measuring system for determining motion status of object and quantifying amount of magnetic particles contained therein

The present invention provides a magnetophorisis measuring system, comprising a microscope device, a magnetic field generator, an image capturing unit, and a processing unit. The microscope device is utilized to magnify a sample liquid having a plurality of objects respectively having a plurality of magnetic particles. The magnetic field generator is utilized to provide an external magnetic field on the sample liquid such that the objects are moved by the external magnetic field. The image capturing unit is utilized to capture a dynamic image with respect to the fluid sample in a view field of the microscope device. The processing unit receives the dynamic image, automatically detects and locks moving objects, determines a motion status corresponding to each object, and quantifies the magnetic particles according to motion status of each object.

System and method for converting optical diameters of aerosol particles to mobility and aerodynamic diameters

A system and a method of measuring a particle's size in a select aerosol using the optical diameter of the particle to perform a mobility and/or aerodynamic diameter conversion without any knowledge about the particle's shape and its optical properties in the aerosol being characterized. In one example embodiment of the invention, the method includes generating a set of calibration data and finding the optimal refractive index and shape that best fits the calibration data. In addition, the method includes creating a new calibration curve that provides a mobility-equivalent or aerodynamic-equivalent diameter.

Device and method for measuring precipitation

A device and method for measuring precipitation, in particular snowfall or hail, which has a measuring chamber for receiving a precipitation particle, at least one light source for radiating the measuring chamber with light, and at least one sensor for sensing an intensity of the light radiating through the measuring chamber. At least two measurement areas, which are arranged one below the other, are provided in the measuring chamber, and the intensity of the light radiating through each of the measurement areas can be detected separately.

Low cost optical high speed discrete measurement system

Systems and methods are provided for determining a velocity or an inflation rate of a droplet in a microfluidic channel. The droplet is exposed to two or more temporally separated flashes of light, each flash including light of one wavelength band, and imaged using a detector configured to distinguish light in the wavelength bands. Two or more images of the droplet are acquired, each corresponding to one of the flashes, and all within a single video frame or photographic exposure. The images can be processed separately and the position or size of the droplet in each image is calculated. A velocity or inflation rate is then determined by dividing the change in position or size by the amount of time allowed to pass between the flashes.

Method for detecting circulating cells in superficial body fluids

The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

Monitor for particle injector

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

Analysis accuracy improvement in automated testing apparatus

Embodiments disclose a device for testing biological specimen. The device includes a receiving mechanism to receive a carrier. The carrier includes a holding area that carries or has been exposed to the biological specimen. The device includes a camera module arranged to capture imagery of the holding area. The camera module includes an focusing motor operable to adjust a focal point of the camera. The device also includes a processor that is configured to utilize the camera module to determine, based on operations of the focusing motor, a volumetric property of the holding area and perform a set of analytic processes on at least a portion of the captured imagery of the holding area to determine one or more properties of the biological specimen.

Methods and apparati for nondestructive detection of undissolved particles in a fluid

The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

Acoustic based cell separation

Apparatus and method for separating whole cells from a mixture, e.g., including liquid, other cell types, nucleic acid material, or other components. Focused acoustic energy may be used to move whole cells in a chamber so that the cells exit the chamber via a first outlet rather than a second outlet. A filter may, or need not, be used to assist in separation.

一种磁感应颗粒检测装置及浓度检测方法

本发明提供一种磁感应颗粒检测装置及浓度检测方法，所述检测装置包括信号检测系统、检测管道、激励线圈，以及正偶数个感应线圈，所述激励线圈与所述信号处理系统连接并绕制于所述检测管道上；所述感应线圈均与所述信号处理系统连接，依次并彼此反向绕制于所述激励线圈上。通过该装置，能够方便制备安装、能够提高检测精度。所述方法包括以下步骤：S1：获取所述信号检测系统的输出信号，得到电压幅度变化情况；S2：根据所获得的电压幅度变化情况，检测金属颗粒浓度。通过该方法，可以提高计算的准确度。

Device and process for detecting particles in a flowing liquid

A device for detecting electrically conductive particles in a liquid flowing in a pipe section, with a transmitter coil surrounding the pipe section for inducing eddy currents in the particles, at least one first inductive receiver coil surrounding the pipe section and a second inductive receiver coil which is spaced axially to the first receiver coil and which surrounds the pipe section, the first and the second receiver coils being located in the region of the transmitter coil and being subtractively connected, in order to output a difference signal according to the eddy currents induced by the transmitter coil, and the transmitter coil forming the primary side and the receiver coils forming the secondary side of a transformer arrangement. An evaluation unit evaluates the difference signal in order to detect passage of electrically conductive particles in the pipe section.

Verfahren und vorrichtung zum messen einer physikalischen und/oder chemischen eigenschaft eines biologischen partikels in einem mikrosystem

Die Erfindung bezieht sich auf ein Verfahren zum Messen einer physikalischen und/oder chemischen Eigenschaft eines biologischen Partikels (5), insbesondere einer Zelle, sowie ein Mikrosystem zum Ausführen des Verfahrens. Das Mikrosystem weist eine Elektrode (la), die zumindest teilweise in einem Aufnahmeraum zum Aufnehmen eines Umgebungsfluids angeordnet ist, und an der Elektrode (la) gebildete Anschlussmittel (7a) zum Abgreifen einer Messgrösse für eine elektrische Eigenschaft der Elektrode (la) auf. Bei der Messung wird das den biologischen Partikel (5) umfassende Umgebungsfluid (4) in den Aufnahmeraum eingeführt, so dass ein Oberflächenabschnitt der Elektrode (la) mit dem Umgebungsfluid (4) in Kontakt gebracht wird. Anschliessend wird der biologische Partikel (5) benachbart zu dem Oberflächenabschnitt angeordnet, so dass der biologische Partikel (5) mit einem Material des Oberflächenabschnitts wechselwirkt und sich eine äussere Oberflächenform des Oberflächenabschnitts aufgrund der Wechselwirkung zwischen dem biologischen Partikel (5) und dem Material verändert. Eine Änderung der Messgrösse für die elektrische Eigenschaft der Elektrode (la) wird gemessen, die sich aufgrund der Veränderung der äusseren Oberflächenform des Oberflächenabschnitts ändert. Mit Hilfe des Verfahrens und des Mikrosystems ist es möglich, Eigenschaften biologischer Partikel individuell und sensitiv zu analysieren.

Microchip, sample sorting kit, and microparticle sorting device

To provide a microchip that is easily handled.Provided is a microchip having a plate shape and including: a sample liquid inlet into which a sample liquid is introduced; a main flow path through which the sample liquid introduced from the sample liquid inlet flows; and a sorting flow path into which a target sample is sorted from the sample liquid, in which the sample liquid inlet and a terminal end of the sorting flow path are formed on a same side surface. Furthermore, a sample sorting kit including the microchip is also provided. Moreover, a microparticle sorting device on which the microchip is mounted is also provided.

颗粒分选的系统、设备和方法

本发明提供的是与流体中的颗粒和细胞分选以及检测有关的细胞检测系统、流体装置、结构以及技术，例如分选特定亚群的细胞类型。用于验证颗粒分选的方法包括：接收与在第一通道中的颗粒的光学特性相关联的第一检测信号。基于第一检测信号来确定多个第二通道的分选通道，由此基于颗粒的光学特性确定将颗粒分选进入分选通道。传输用于将颗粒从第一通道分选进入分选通道中的分选信号。第二检测信号被接收，其与在分选通道中颗粒的存在相关联。基于第二检测信号，验证颗粒从第一通道中分选进入分选通道中。

금속 산화물 겔 입자 크기 제어 시스템 및 방법

금속 산화물 겔 입자는 공급 용액으로서 헥사메틸렌 테트라민을 함유하는 저온 금속 질산염 수용액을 제조하는 단계; 및 공급 용액을 제1 튜브를 통해 흐르게 하고 제1 스트림으로서 제1 유량으로 제1 튜브를 빠져나가게 하여 고온 비수성 구동 유체와 접촉시킴으로써 원하는 입자 크기로 제조될 수 있다. 구동 유체는 제2 튜브를 통해 제2 유량으로 흐른다. 제1 스트림과 구동 유체 사이의 전단은 제1 스트림을 금속 질산염 용액의 입자로 분열시키고, 헥사메틸렌 테트라민의 분해는 금속 질산염 용액 입자를 금속 산화물 겔 입자로 전환시킨다. 금속 산화물 겔 입자 크기는 구동 유체의 스트림 내의 금속 산화물 겔 입자의 흐름으로 향하는 센서 장치를 사용하여 광학적으로 측정된다. 센서 장치는 금속 산화물 겔 입자 또는 구동 유체 중 어느 하나에 의해 흡수되는 광의 투과율을 측정하며, 따라서 구동 유체를 통한 광의 투과율은 금속 산화물 겔 입자가 광학 센서를 통과함에 따라 일정 기간 동안 변한다. 측정된 입자 크기가 원하는 입자 크기와 거의 동일하지 않은 경우, 전체 유량에 대한 제1 유량의 비율을 조정함으로써 입자 크기가 교정된다(여기서 전체 유량은 제1 유량과 제2 유량의 합이다).

颗粒传感器设备

本发明涉及颗粒传感器设备，具有：光学发射装置，所述光学发射装置设计用于发射光学辐射，使得能够至少部分地照射可能具有至少一个颗粒的容积；光学探测装置，所述光学探测装置具有至少一个探测面，在所述至少一个颗粒上散射的光学辐射的至少一部分入射到所述至少一个探测面上，其中，能够输出关于入射到所述至少一个探测面上的光学辐射的强度和/或强度分布的至少一个信息信号；分析处理装置，借助所述分析处理装置能够确定和输出关于颗粒的存在、颗粒数量、颗粒密度和/或颗粒的至少一个特性的信息；所述颗粒传感器设备还包括至少一个透镜元件，所述至少一个透镜元件布置为使得所发射的光学辐射能够聚焦到所述容积内的聚焦区域上。

Microorganism evaluation system

유체 흐름 내의 미생물을 분석하기 위한 미생물 평가 시스템으로서, 미생물 자극부를 통해 지나는 유체 흐름 내의 살아있는 미생물의 운동 반응(motive response)을 유도하는 유도 수단을 포함하는, 미생물 자극부; 및 상기 미생물 자극부와 유체 소통하는 관측부를 포함하고, 상기 관측부는 몸체 내에 형성되는 공동 제1 개구부를 통해 볼 수 있는 관측 포트를 규정하는 몸체 공동(body cavity)을 내부에 형성하는 몸체를 포함하여, 몸체 공동과 소통하고, 상기 관측부는 상기 공동 제1 개구부를 통해 상기 관측 포토 내의 유체 흐름을 관측하기 위해 몸체에 대하여 탑재된 광학 시스템을 더 포함하고, 상기 유체 흐름에 관련된 이미지 데이터 및 유체 흐름 내의 미생물이 분석을 위해 상기 광학 시스템을 통해 획득된다.

Laser sensor for particle size detection

本发明描述一种用于颗粒尺寸检测的激光传感器模块（100）。该激光传感器模块（100）包括至少一个第一激光器（110）、至少一个第一检测器（120）、至少一个电驱动器（130）和至少一个评估器（140）。该第一激光器（110）适配成响应于由所述至少一个驱动器（130）提供的信号而发射第一激光。该至少一个第一检测器（120）适配成确定第一激光器（110）的第一激光腔内的光波的第一自混合干涉信号（30）。该第一自混合干涉信号（30）是由重新进入第一激光腔的第一反射激光引起的，该第一反射激光被接收第一激光的至少一部分的颗粒反射。该评估器（140）适配成通过借助于第一自混合干涉信号（30）确定颗粒与第一激光器（110）之间的第一相对距离并且通过借助于第一自混合干涉信号（30）确定第一振幅信息来确定颗粒的尺寸。本发明还涉及确定颗粒尺寸的相应方法。

Methods of separating, identifying and dispensing specimen and device therefor, and analyzing device method

在分离部，可以确认分离状态，在检测部，提高照射效率、受光灵敏度，在分注部，保证试样为正常状态。一种试样分离装置，其特征在于，具备：收容有试样的容器；用于从所述容器吸入、排出试样的喷嘴；用于使所述喷嘴上下左右运动的喷嘴动作机构；用于控制所述喷嘴的吸入力、排出力的喷嘴控制机构。另外，一种试样识别装置，其特征在于，具备：从收容有试样的容器吸入试样的喷嘴；用于使试样流动的流路；用于观察(监视)试样的监控光照射部及受光部设置于流路的测定部，所述喷嘴、所述流路及所述测定部形成为一体结构。

Laser-guided incandescent particle sensor with confocal placement of laser spot and thermal radiation spot

본 발명은 레이저를 갖는 레이저 모듈(18), 및 열 방사선(14)을 검출하도록 설계된 검출기(26)를 포함하는 입자 센서(16)에 관한 것이다. 입자 센서(16)는 레이저 모듈(18)로부터 방출되는 레이저 광을 제 1 스폿(22)에 포커싱하도록 설계되며 제 1 스폿(22)으로부터 방출되는 열 방사선(14)을 제 2 스폿에 포커싱하도록 설계된 광학 장치(36)를 포함하고, 검출기(26)의 방사선 감지면은 제 2 스폿에서 또는 상기 제 2 스폿에 포커싱된 열 방사선(14)의 빔 경로에서 상기 제 2 스폿 뒤에 있는 것을 특징으로 한다.

Low cost optical high speed discrete measurement system

Systems and methods are provided for determining a velocity or an inflation rate of a droplet in a microfluidic channel. The droplet is exposed to two or more temporally separated flashes of light, each flash including light of one wavelength band, and imaged using a detector configured to distinguish light in the wavelength bands. Two or more images of the droplet are acquired, each corresponding to one of the flashes, and all within a single video frame or photographic exposure. The images can be processed separately and the position or size of the droplet in each image is calculated. A velocity or inflation rate is then determined by dividing the change in position or size by the amount of time allowed to pass between the flashes.

Method for measuring particles in light beam in laser welding based on sandwich model constrained plume

一种基于“三明治”模型约束羽辉的激光焊接光束内微粒的测量方法属于激光焊接领域。其特征在于：两块透明板材以一定间距组成“三明治”模型并置于被焊接板材上方，激光束穿过“三明治”模型的中间空隙焊接板材；利用“三明治”模型约束焊接空间中的微粒，使激光束范围内的待测区域显露出来；探测系统的探测光通过透明材料穿过激光束，部分探测光被光束内的微粒反射回探测激光腔内形成新的谐振，通过测量探测激光器电压、频率的变化，可以得到焊接激光束内微粒的尺寸、数量、速度等信息。本发明具有系统结构简单、易于操作、不受探测激光功率波动影响、成本低廉等优点，能够原位实时测量焊接过程中激光束内不同高度处微粒的尺寸和速度。

Dual use detectors for flow cytometry

一种对准光束与流体中的核心流的光学准直系统。该流体可具有鞘液和核心流，其中核心流在流体中具有流动的位置。光源可用于产生光束，并且光学元件可用于把光束对准核心流。在某些描述性实施例中，启动器被提供用于移动光学元件、光源和/或流体从而被光学元件指引的光与核心流的当前位置对准。

Magnetic induction particle detection device and concentration detection method

本发明提供一种磁感应颗粒检测装置及浓度检测方法，所述检测装置包括信号检测系统、检测管道、激励线圈，以及正偶数个感应线圈，所述激励线圈与所述信号检测系统连接并绕制于所述检测管道上；所述感应线圈均与所述信号检测系统连接，依次并彼此反向绕制于所述激励线圈上。通过该装置，能够方便制备安装、能够提高检测精度。所述方法包括以下步骤：S1：获取所述信号检测系统的输出信号，得到电压幅度变化情况；S2：根据所获得的电压幅度变化情况，检测金属颗粒浓度。通过该方法，可以提高计算的准确度。

Device measuring parameters of structural elements in sample of textile material

Предлагается испытательный прибор, содержащий приемник для удержания множества образцов текстильного материала и автоматический механизм подачи, расположенный рядом с приемником для выборочного зацепления и удаления образцов из приемника и транспортировки их к средству обработки, где образец текстильного материала обрабатывается для получения структурных элементов в индивидуализированном состоянии. Затем структурные элементы транспортируются к датчику, который выдает сигналы, соответствующие параметрам структурных элементов. Устройство управления обнаруживает присутствие или отсутствие образца в автоматическом механизме подачи и осуществляет соответствующее управление. Аналоговые и цифровые компоненты анализируют параметрические сигналы для идентификации сегментов параметрических сигналов, соответствующих непсам, сорной примеси и волокнам

Resistance type micro sensor

本发明提供一种电阻式微传感器，包括待测液流道、两个微电极流道和微电阻检测线路；其中，两个微电极流道对称设置于待测液流道的两侧，微电极流道内填充导电液体形成微电极，微电极流道和待测液流道内的待测液构成微电阻，两个微电极流道均与微电阻检测线路相连接。本发明在微电极流道内填充导电液体形成微电极，与现有技术采用金属溅射的方法在微流道的下部沉积出微电极相比，不需溅射贵重金属(如铂、金等)，提高了电阻式微传感器的稳定性，具有工艺简单、耗时短的优点，降低了成本。当有待测液或微粒通过待测液流道时，通过微电阻检测线路检测电阻值的变化，并通过监测微电阻的阻值变化规律，可分析得到待测液的流速、体积、组分等参数。

Method and device for determining position of feed opening

本发明公开了一种确定下料口位置的方法和装置。其中，应用于飞行器的播撒装置中，其中，播撒装置至少包括两个播撒甩盘和两个下料口，一个播撒甩盘与一个下料口相对应，该方法包括：获取每个播撒甩盘的第一播幅以及每个播撒甩盘的转速；根据第一播幅以及转速确定第一播幅与下料口的位置信息之间的第一关系；获取两个播撒甩盘之间的中心距以及两个播撒甩盘对应的第二播幅，其中，第一播幅和第二播幅由下料口的位置信息确定；根据第二播幅以及中心距确定第二播幅与下料口的位置信息之间的第二关系；根据第一关系和第二关系确定下料口的位置信息。本发明解决了现有技术中无法准确确定下料口位置所导致的作业效率低的技术问题。

Device for measuring wind speed

Sensor arrangement for characterizing particles

본 발명은, 다음의 것을 포함하는, 입자(P)를 특성 묘사하기 위한, 특히 입자 위치(P X , P Y ), 입자 속도(v X , v Y ), 입자 가속도(a X , a Y ) 및/또는 입자 사이즈(D)를 결정하기 위한 센서 배열체(1)에 관한 것이다: 방출기(2) - 방출기(2)는: 레이저 빔(3)을 생성하기 위한 레이저 소스(5), 각각의 위치(X, Y)에서 레이저 빔(3)의 국소적 강도(I(X, Y)) 및 국소적 편광 방향(R(X, Y))의 상이한 조합을 갖는 레이저 빔(3)의 필드 분포를 생성하기 위한 모드 변환 디바이스(7), 레이저 빔(3)의 필드 분포(11)를, 초점 평면(9)에서 입자(P)가 통과하는 적어도 하나의 측정 영역(10) 상으로 포커싱하기 위한 포커싱 광학기기(8)를 구비함 - , 수신기(4) - 수신기(4)는: 적어도 하나의 측정 영역(10)에서 레이저 빔(3)의 필드 분포의 편광 종속 강도 신호(I 1 , I 2 , I 3 , I 4 )를 결정하기 위한 분석기 광학기기(14), 및 입자(P)를 특성 묘사하기 위한, 특히, 편광 종속 강도 신호(I 1 , I 2 , I 3 , I 4 )의 도움으로 입자 위치(P X , P Y ), 입자 속도(v X , v Y ), 입자 가속도(a X , a Y ) 및/또는 입자 사이즈(D)를 결정하기 위한 평가 디바이스(20)를 구비함 - . 본 발명은 또한, 그러한 센서 배열체(1)를 구비하는, 특히 EUV 방사선 생성 장치에 대한 광학 배열체에 관한 것이다.

METHOD AND DEVICE OF SYNCHRONOUS HIGH-SPEED PHOTO PHOTOGRAPHY OF ROTATION OF A microparticle in the field of a HYDROCYCLONE

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2017 103 913 A (51) МПК G01P 3/38 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2017103913, 15.06.2015 (71) Заявитель(и): ИСТ ЧАЙНА ЮНИВЕРСИТИ ОФ САЙЕНС ЭНД ТЕКНОЛОДЖИ (CN) Приоритет(ы): (30) Конвенционный приоритет: 08.07.2014 CN 201410323142.1; 08.07.2014 CN 201410323160.X (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.02.2017 CN 2015/081425 (15.06.2015) (87) Публикация заявки PCT: WO 2016/004810 (14.01.2016) A Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, стр. 3, ООО "Юридическая фирма Городисский и Партнеры" R U (57) Формула изобретения 1. Способ синхронной высокоскоростной фотосъемки вращения микрочастицы в поле гидроциклона, содержащий: (1) использование прозрачной микрочастицы, содержащей два внутренних ядра, обладающих одинаковым диаметром и расположенных центросимметрично, в качестве частицы для испытания на вращение; (2) синхронный прием двух групп из серий двумерных изображений движения микрочастицы в поле гидроциклона с использованием двух перпендикулярно расположенных высокоскоростных цифровых фотокамер; и (3) реконструкцию трехмерной траектории движения микрочастицы из двух групп серий синхронных изображений и одновременно определение скорости вращения микрочастицы в поле циклона. 2. Способ по п. 1, в котором частица для испытания на вращение представляет собой сферическую частицу, обладающую прозрачной или полупрозрачной оболочкой и содержащую две центросимметрично расположенные частицы внутреннего ядра, которые обладают насыщенным цветом и одинаковым диаметром, причем частица для испытания обладает диаметром менее 500 микрон и высокой микродисперсностью (коэффициент вариации <5%). 3. Способ по п. 1, в котором две высокоскоростные цифровые фотокамеры Стр.: 1 A 2 0 1 7 1 0 3 9 1 3 (54) СПОСОБ И УСТРОЙСТВО СИНХРОННОЙ ВЫСОКОСКОРОСТНОЙ ФОТОСЪЕМКИ ВРАЩЕНИЯ МИКРОЧАСТИЦЫ В ПОЛЕ ГИДРОЦИКЛОНА 2 0 1 7 1 0 3 9 1 3 (86) Заявка PCT: R ...

Active droplet generation device capable of controlling droplet size, droplet size control method using the same, and droplet generation self-diagnosis device

본 발명은 액적의 크기 제어가 가능한 능동형 액적 생성장치, 이를 이용한 액적 크기 제어방법 및 액적 생성 자가진단 장치에 관한 것으로서, 시료가 유입되는 시료 유입구와, 오일이 유입되는 오일 유입구와, 상기 유입구들을 통해 유입된 유체가 통과하는 마이크로채널과, 상기 마이크로채널을 통과한 유체가 배출되는 배출구가 형성되는 일회용 마이크로채널 상판과, 상기 일회용 마이크로채널 상판과 별도로 분리되어 영구사용이 가능한 다기능성 하판과, 상기 상판의 하면에 구비되어 상판과 하판을 분리하면서 마이크로채널 내 공기 방울을 실시간으로 제거할 수 있는 기능성 고분자 필름과, 상기 하판의 상면에 패터닝되어 상기 마이크로채널을 통과하는 유체의 전압 값을 통해 액적의 크기를 측정하는 액적 측정전극과, 상기 상판과 하판이 진공에 의해 결합 또는 분리 가능하도록 상기 상판과 하판 사이에 음압을 인가하기 위한 음압형성수단과, 상기 액적 측정전극에서 측정한 전압 값을 피드백받아 상기 오일과 시료의 유속을 제어하여 액적의 사이즈를 원하는 크기로 조절하기 위한 유속제어장치를 포함함으로써, 정전용량 임피던스 기법으로 액적 크기를 빠르고 정확하게 측정하여 피드백 제어방식으로 액적의 크기를 제어할 수 있는 효과가 있다.

A kind of resistance-type microsensor

本发明提供一种电阻式微传感器，包括待测液流道、两个微电极流道和微电阻检测线路；其中，两个微电极流道对称设置于待测液流道的两侧，微电极流道内填充导电液体形成微电极，微电极流道和待测液流道内的待测液构成微电阻，两个微电极流道均与微电阻检测线路相连接。本发明在微电极流道内填充导电液体形成微电极，与现有技术采用金属溅射的方法在微流道的下部沉积出微电极相比，不需溅射贵重金属(如铂、金等)，提高了电阻式微传感器的稳定性，具有工艺简单、耗时短的优点，降低了成本。当有待测液或微粒通过待测液流道时，通过微电阻检测线路检测电阻值的变化，并通过监测微电阻的阻值变化规律，可分析得到待测液的流速、体积、组分等参数。

Variable-motion optical tomography of small objects

一种靶目标(1)的三维(3D)重构方法，包括如下步骤：把靶目标装在线形容器(31)内。用至少一个光学投影光束(13)照明靶目标(1)。运送线形容器(32)直到靶目标(1)位于至少一个光学投影光束(13)的区域内。根据需要使所述至少一个靶目标(33)位于中心并旋转靶目标通过多个径向角度，以便在多个角度中的每个径向角度产生一系列投影像(34)。

Device and method for flow and bead speed characterization in microfluidic devices

Method, apparatus, and computer program product for a microfluidic channel having a cover opposite its bottom, the cover allowing visual inspection inside the channel, and having electrodes with patterned planar conducting materials, integrated onto its bottom. Using the planar conducting materials, once a fluid sample with suspended microparticles is applied into the channel, highly localized modulated electric field distributions are generated inside the channel and the fluid sample. This generated field causes inducing of dielectrophoretic (DEP) forces such that the DEP forces gradually increase along the length of the channel occupied by the electrodes. These DEP forces counteract the hydrodynamic drag of the flow acting on the particles suspended in the fluid. Because of the induced forces, micro/nano-particles in the fluid sample are deflected at locations in the microchannel that are a function of the particles velocity and this effect is captured by an image sensing device.

KIT FOR SIMPLE TESTING OF Spermatozoa, SYSTEM AND METHOD FOR SIMPLE TESTING OF Spermatozoa

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2018 135 232 A (51) МПК G01N 33/483 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2018135232, 08.03.2017 (71) Заявитель(и): РИКРЮТ КО., ЛТД. (JP) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ИРИСАВА Рё (JP) 08.03.2016 JP 2016-044615 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 05.10.2018 R U (43) Дата публикации заявки: 06.04.2020 Бюл. № 10 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2017/154974 (14.09.2017) A Адрес для переписки: 125167, Москва, ул. Викторенко, 5, стр. 1, Бизнес Центр Виктори Плаза, патентно-лицензионная фирма "Транстехнология", Чалушкиной Е.А. R U (57) Формула изобретения 1. Набор для простого тестирования сперматозоидов, обеспечивающий выполнение простого тестирования сперматозоидов, содержащий: одну подложку, размещаемую над камерой информационного терминала, выточку на поверхности подложки, предназначенную для спермы, крышку, закрывающую выточку и обеспечивающую возможность прохождения внешнего светового излучения в выточку, и линзу, закрепленную внутри подложки с нижней стороны выточки и предназначенную для увеличения изображения спермы внутри выточки и проецирования этого изображения на заднюю поверхность подложки. 2. Набор для простого тестирования сперматозоидов по п. 1, отличающийся тем, что крышка образует одно целое с подложкой, и на участке крышки сформирован вырез. 3. Набор для простого тестирования сперматозоидов по п. 1 или 2, отличающийся тем, что задняя поверхность крышки подвергнута гидрофильной обработке. 4. Набор для простого тестирования сперматозоидов по п. 1 или 2, отличающийся тем, что в выточке установлены проставки для фиксации расстояния между донной поверхностью выточки и задней поверхностью крышки, причем эти проставки установлены в положениях, перекрывающихся на виде сверху с линзой. Стр.: 1 A 2 0 1 8 1 3 5 2 3 2 (54) НАБОР ДЛЯ ПРОСТОГО ТЕСТИРОВАНИЯ СПЕРМАТОЗОИДОВ, СИСТЕМА И СПОСОБ ...

DEVICE FOR MEASURING WIND SPEED

Method for measuring wind speed

本发明涉及一种设备，其包括：用于发射称之为发射光束的激光束的部件（12）；用于以预定焦距（D）聚焦发射光束的部件（16）；用于接收被空气中的粒子（18）反射后的发射光束称之为反射光束的部件（20）；用于传输信号的部件（32），由其将发射光束和反射光束间形成干涉的信号传输至信号处理部件（24），由此推断出粒子的速度。发射部件（12）包括激光二极管，接收部件（20）通过自混合与激光二极管组合在一起。焦距（D）为5厘米至2米。

Method and equipment for controlling movement of particles in solution by using ultrahigh frequency sound wave

本发明公开了一种控制流体中的目标颗粒移动的微流控系统及方法。本发明的系统包括流体通道，其具有入口和多个出口；一个或多个超高频声波谐振器，所述超高频体声波谐振器可在所述流体通道产生频率为约0.5‑50GHz的体声波；通过调节超高频体声波谐振器体声波产生区域的形状和设置方位，使得颗粒在进入体声波在溶液中引发的涡旋通道，按指定位置和方向移动。本发明的系统和方法可以对溶液中的颗粒进行控制和分离，得到指定的颗粒，或得到分离颗粒后的纯化的溶液。

Single molecule tracking

SINGLE MOLECULE TRACKING ABSTRACT OF THE DISCLOSURE A detection system is provided for identifying individual particles or molecules having characteristic emission in a flow train of the particles in a flow cell. A position sensitive sensor is located adjacent the flow cell in a position effective to detect the emissions from the particles within the flow cell and to assign spatial and temporal coordinates for the detected emissions. A computer is then enabled to predict spatial and temporal coordinates for the particle in the flow train as a function of a first detected emission. Comparison hardware or software then compares subsequent detected spatial and temporal coordinates with the predicted spatial and temporal coordinates to determine whether subsequently detected emissions originate from a particle in the train of particles. In one embodiment, the particles include fluorescent dyes which are excited to fluoresce a spectrum characteristic of the particular particle. Photons are emitted adjacent at least one michrochannel plate sensor to enable spatial and temporal coordinates to be assigned. The effect of comparing detected coordinates with predicted coordinates is to define a moving sample volume which effectively precludes the effects of background emissions.

Tumor cell screening microfluidic device and method based on droplet deposition

本发明涉及一种基于液滴寄存的肿瘤细胞筛查微流控装置及筛查方法，属于微流控技术领域。本发明包括玻璃基片和固定在其上的PDMS芯片，其中PDMS材料构成整个芯片，通过微细加工技术制作微通道结构，通过十字型结构生成一个液滴包裹一个血红细胞或者肿瘤细胞，然后经过液滴寄存被动阀，由于血红细胞和肿瘤细胞的尺寸和柔软程度差异，包裹血红细胞的液滴和包裹肿瘤细胞的液滴通过液滴寄存器的个数不一样，通过激光检测液滴通过的个数，从而检测出是否有肿瘤细胞，实现极少样品量的高灵敏度实时检测。本发明实现了将流体采样、驱动、操控、运输及检测分析集成于微流控芯片上，实现液体流动可控、微量及痕量物质的输运以及高效检测。

Electrochemical detection of magnetic particle mobility.

Una modalidad de ejemplo de la invención puede incluir un método para monitorear electroquímicamente la movilidad de partículas en un fluido en respuesta a un campo externo, el método puede incluir monitorear una característica eléctrica del fluido en una celda electroquímica, el fluido que comprende partículas que pueden ser movidas bajo la influencia de un campo aplicado externamente; observar cambios en la característica eléctrica causados por el movimiento de partículas inducido por el campo externo; e inferir un cambio en el estado físico del fluido a partir de un cambio en la magnitud de la característica eléctrica observada.

Light-trapping cancer cell stage testing method

Optical particle sensor module

本发明描述一种激光传感器模块。所述激光传感器模块包括：适用于发射第一测量光束(111')的至少第一激光器(111)和适用于发射第二测量光束(112')的至少第二激光器(112)；光学装置(150)，其设置用于至少将所述第一测量光束(111')聚焦到第一测量区(161)，所述光学装置还设置用于至少将所述第二测量光束(112')聚焦到第二测量区(162)，其中，所述光学装置的特征在于关于所述第一测量光束(111')的第一数值孔径和关于所述第二测量光束(112')的第二数值孔径，其中，所述第一数值孔径和所述第二数值孔径设置用以在参考速度下检测预定的最小颗粒尺寸，其中，所述参考速度在包括所述参考速度的0.01m/s与7m/s之间的预定的速度范围内进行选择，其中，所述第一测量光束(111')和所述第二测量光束(112')相互围成10°和160°之间的角度；至少第一检测器(121)，其适用于确定所述第一激光器(111)的第一激光器腔内的第一光波的第一自混合干涉信号；至少第二检测器(122)，其适用于确定所述第二激光器(112)的第二激光器腔内的第二光波的第二自混合干涉信号；分析处理装置(140)，其中，所述分析处理装置(140)适用于接收由至少第一检测器(121)和第二检测器(122)响应于所确定的自混合干涉信号而产生的检测信号，其中，所述分析处理装置(140)还适用于通过在预定的时间段内接收到的检测信号来确定由所述第一检测器(121)检测到的颗粒的至少第一平均速度和由所述第二检测器(122)检测到的颗粒的至少第二平均速度，其中，所述分析处理装置(140)还适用于基于由所述第一检测器(121)在预定的时间段内提供的检测信号来确定颗粒的至少第一数量并且基于由所述第二检测器(122)在预定的时间段内提供的检测信号来确定颗粒的至少第二数量，其中，所述分析处理装置(140)还适用于基于平均颗粒速度来确定颗粒密度，所述平均颗粒速度至少通过所述第一平均速度和所述第二平均速度、所述颗粒的至少第一数量和所述颗粒的至少第二数量来确定。本发明还涉及一种颗粒密度检测的方法和一种相应的计算机程序产品。本发明还涉及一种包括这样的激光传感器模块(100)的移动通信装置(190)。

Electrophoresis particle characterisation

Means for determining test particle charge in an electrophoresis system comprises applying one of an electric current or a voltage across an aperture 10 connecting two chambers14, 15, whereby the chambers are at least partially filled with electrolyte and whereby at least one test particle is suspended in the electrolyte of at least one of the chambers; measuring the other of the current or voltage across the aperture; varying a pressure differential between the two chambers; and determining the charge based on the measurements of the electric current or voltage. Direction, velocity, concentration, and distribution of particles may also be determined. Monitoring of blockade events, particle types and driving force balance is also disclosed. An electrophoresis variable pressure system is also disclosed.

The device of the particle suspended in real time in analysis fluid and the method for analyzing the particle

本发明涉及一种用于分析颗粒的装置，其包括被配置为容纳定位流体的分析室。利用检测和控制单元来检测悬浮在定位流体中的颗粒的参数。在颗粒分析操作期间，基于所检测到的颗粒的参数来启用和停用定位单元。检测和控制单元可以启用至少一个定位单元以在定位流体中产生临时定位流，使得所述临时定位流直接作用于颗粒并且驱动颗粒的位置以使该颗粒移动到分析室内的预定义位置。在待分析颗粒处于预定义位置的情况下，检测和控制单元还可以停用至少一个定位单元，使得定位流体静止。

The separation of sample, identification, dispensing method and its device and resolver

在分离部，可以确认分离状态，在检测部，提高照射效率、受光灵敏度，在分注部，保证试样为正常状态。一种试样分离装置，其特征在于，具备：收容有试样的容器；用于从所述容器吸入、排出试样的喷嘴；用于使所述喷嘴上下左右运动的喷嘴动作机构；用于控制所述喷嘴的吸入力、排出力的喷嘴控制机构。另外，一种试样识别装置，其特征在于，具备：从收容有试样的容器吸入试样的喷嘴；用于使试样流动的流路；用于观察(监视)试样的监控光照射部及受光部设置于流路的测定部，所述喷嘴、所述流路及所述测定部形成为一体结构。

Velocimetry-based identification of single proteins and other particles

Spatially distributed optical excitation and integrated waveguides are used for ultrasensitive particle detection based on individual electrokinetic velocities of particles. In some embodiments, chip-integrated systems are used to identify individual particles (e.g., individual molecules) based on their velocity as they move through an optically interrogated channel. Molecular species may be identified and quantified in a fully integrated setting, allowing for particle analysis including molecular analysis that can operate at low copy numbers down to the level of single-cell lysates. In some embodiments, the single-particle velocimetry-based identification and/or separation techniques are applied to various diagnostic assays, including nucleic acids, metabolites, macromolecules, organelles, cell, synthetic markers, small molecules, organic polymers, hormones, peptides, antibodies, lipids, carbohydrates, inorganic and organic microparticles and nanoparticles, whole viruses, and any combination thereof.

Variable-motion optical tomography of small objects

A method for three dimensional (3D) reconstruction of an object of interest (1), includes the step of packing objects of interest into a linear container (31). An object of interest (1) is illuminated with at least one optical projection beam (13). The linear container (32) is translated until the object of interest (1) is located within a region of the at least one optical projection beam (13). The object of interest (33) is centered as necessary and rotated through a plurality of radial angles to generate a set of projection images (34) at each radial angle of the plurality of angles.

Common radiation path for acquiring particle information by means of direct image evaluation and differential image analysis

Vorrichtung (100) zum Ermitteln von für eine Partikelgröße und/oder Partikelform von Partikeln in einer Probe indikativer Information, wobei die Vorrichtung (100) eine elektromagnetische Strahlungsquelle (102) zum Erzeugen von elektromagnetischer Primärstrahlung (108), einen elektromagnetischen Strahlungsdetektor (104) zum Detektieren von elektromagnetischer Sekundärstrahlung (110), die durch Wechselwirkung der elektromagnetischen Primärstrahlung (108) mit der Probe erzeugt wird, und eine Ermittlungseinrichtung (106) aufweist, die zum Ermitteln der für die Partikelgröße und/oder Partikelform indikativen Information basierend auf der detektierten elektromagnetischen Sekundärstrahlung (110) eingerichtet ist, wobei die Ermittlungseinrichtung (106) ausgebildet ist, die Information selektiv erstens (112) mittels einer Identifizierung und Größenbestimmung und/oder Formbestimmung der Partikel auf einem aus der elektromagnetischen Sekundärstrahlung (110) generierten Detektorbild zu ermitteln, und/oder die Information zweitens (114) aus zeitlichen Veränderungen der elektromagnetischen Sekundärstrahlung (110) zwischen zu unterschiedlichen Detektionszeitpunkten generierten Detektorbildern zu ermitteln.

Portable flow cytometer for detecting scattering light and fluorescence light

一种设备(10)具有检测、分析和识别血液或其他所研究的流体中的散射光和多色荧光的能力。待检样品可注入一次性的微流体盒(14)中，后者可插入一个可手持的或是可植入体内的小型便携式流式血细胞计数器(10)中。该血细胞计数器(10)在生物战病原体检测、血液学、其他临床和研究领域可得到重要应用。

Characterization of motion-related error in a stream of moving micro-entities

描述了用于检测和表征移动微实体的运动相关误差的设备和方法。运动相关误差可出现在移动微实体的流中，并且可表示期望到达时间的偏差或微实体位置的不确定性。在流式细胞计中观测到的微实体的运动相关误差，例如为脉冲抖动，并且被发现具有与关于系统时钟的参数的函数相关性。可通过关联在流体流中移动的微实体的测量结果来表征运动相关误差。

Cell culture and gradient migration assay methods and devices

本发明公开了用于微流控侵袭化验系统的制造和操作的多个新颖的改进的微流控配置和系统和方法。

Method and device for determining position of feed opening

本发明公开了一种确定下料口位置的方法和装置。其中，应用于飞行器的播撒装置中，其中，播撒装置至少包括两个播撒甩盘和两个下料口，一个播撒甩盘与一个下料口相对应，该方法包括：获取每个播撒甩盘的第一播幅以及每个播撒甩盘的转速；根据第一播幅以及转速确定第一播幅与下料口的位置信息之间的第一关系；获取两个播撒甩盘之间的中心距以及两个播撒甩盘对应的第二播幅，其中，第一播幅和第二播幅由下料口的位置信息确定；根据第二播幅以及中心距确定第二播幅与下料口的位置信息之间的第二关系；根据第一关系和第二关系确定下料口的位置信息。本发明解决了现有技术中无法准确确定下料口位置所导致的作业效率低的技术问题。

Methods and apparati for nondestructive detection of undissolved particles in a fluid

The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

Device for real time analysis of particles suspended in a fluid and method for the analysis of said particles

The present invention refers to a device for the analysis of a particle comprising an analysis chamber adapted to contain a positioning fluid. A parameter of the particle suspended in the positioning fluid is detected by means of a detection and control unit. A positioning unit, during a particle analysis operation, is activated and deactivated on the basis of the detected parameter of the particle. The detection and control unit can activate the at least one positioning unit so as to generate a temporary positioning flow in the positioning fluid, such that said temporary positioning flow acts directly on the particle and drives the position of the particle so as to move it into a predefined position in the analysis chamber. The detection and control unit can also deactivate the at least one positioning unit when the particle to be analyzed is in the predefined position, such that the positioning fluid is at rest.

Method for correction of relative object-detector motion between successive views

Motion correction for optical tomographic imaging in three dimensions. An object of interest (1) is illuminated to produce an image (111). A lateral offset correction value is determined for the image (114). An axial offset correction value is determined for the image 115). The lateral offset correction value and the axial offset correction value are applied to the image to produce a corrected file image (116).

The compensation of the motion-related error in mobile micro-entity stream

描述了用于检测、表征和补偿移动微实体的运动相关误差的设备和方法。运动相关误差可出现在移动微实体的流中，并且可表示期望到达时间的偏差或流中微实体位置的不确定性。微实体的运动相关误差（例如脉冲抖动）在流式细胞计中观测到，并且被发现具有与系统的参数的函数相关性。根据一个实施例，可通过调节数据获取观测窗来补偿脉冲抖动。对于流式细胞计，脉冲抖动的减小可以改善测量准确性、双液滴的分辨率、系统处理量以及能增大用于探测微实体的询问区域。

Method and system for characterizing the movement speed of particles contained in a liquid, such as blood particles

This method is suitable for characterising a variation in the speed of particles or an agglomeration of particles, said particles, such as blood particles, being contained in a liquid (12). The characterisation method comprises the following steps: - introducing the liquid (12) into a fluid chamber (14); - illuminating the fluid chamber (14) via an excitation light beam (18) emitted by a light source (16), the light beam (18) extending through the fluid chamber (14) in a longitudinal direction (X); - the acquiring of at least one image by a matrix photodetector (20), the image being formed by a ray transmitted by the illuminated fluid chamber (14); and - calculating, based on at least one acquired image, at least one indicator characterising the variation in the speed of the particles or agglomeration of particles. During the acquisition step, the photodetector (20) is arranged at a distance (D2) less than 1 cm from the fluid chamber (14) in the longitudinal direction (X).

Patent FR2438835B1

tracking and characterizing particles with holographic video microscopy

本发明涉及用全息视频显微术来跟踪和表征颗粒。本发明提供了产生诸如分散在透明介质中的一个或多个颗粒等样品的图像的同轴全息术。用来自光散射理论的结果来分析这些图像提供具有纳米尺寸分辨率的颗粒尺寸、在千分之一以内的其折射率、及具有纳米分辨率的其三维空间位置。此程序快速并直接地表征样品及其介质的机械、光学和化学性质。

Variable moving optical tomography of minute objects

目的対象物（１）の三次元（３Ｄ）復元のための方法が、目的対象物を直線形の容器に詰め込む工程（３１）を含む。目的対象物（１）は少なくとも１つの光学投影ビーム（１３）で照明される。目的対象物（１）が少なくとも１つの光学投影ビーム（１３）の領域内に配置されるまで直線形の容器が平行移動させられる（３２）。目的対象物は必要に応じて中心に据えられ（３３）、複数の半径方向角度まで回されることで複数の角度の各々の半径方向角度で投影画像のセットを発生させる（３４）。

Simple sperm test kit, system, and method for performing simple test on sperm

本發明之用於執行精子之簡易檢查之精子簡易檢查套組10具有：基板20，其可載置於資訊終端11之相機30之上；凹部21，其設置於基板20之表面，且收納精液A；蓋22，其覆蓋凹部21，且使外部光入射至凹部21；及透鏡23，其設置於凹部21的下側之基板20內部，將凹部21內之精液A放大且映現於基板20之背面側。

Portable flow cytometer for detecting scattering light and fluorescence light

Electrodynamic particle size analyzer

Optical particulate sensor module

本发明描述一种激光传感器模块。所述激光传感器模块包括：适用于发射第一测量光束(111')的至少第一激光器(111)和适用于发射第二测量光束(112')的至少第二激光器(112)；光学装置(150)，其设置用于至少将所述第一测量光束(111')聚焦到第一测量区(161)，所述光学装置还设置用于至少将所述第二测量光束(112')聚焦到第二测量区(162)，其中，所述光学装置的特征在于关于所述第一测量光束(111')的第一数值孔径和关于所述第二测量光束(112')的第二数值孔径，其中，所述第一数值孔径和所述第二数值孔径设置用以在参考速度下检测预定的最小颗粒尺寸，其中，所述参考速度在包括所述参考速度的0.01m/s与7m/s之间的预定的速度范围内进行选择，其中，所述第一测量光束(111')和所述第二测量光束(112')相互围成10°和160°之间的角度；至少第一检测器(121)，其适用于确定所述第一激光器(111)的第一激光器腔内的第一光波的第一自混合干涉信号；至少第二检测器(122)，其适用于确定所述第二激光器(112)的第二激光器腔内的第二光波的第二自混合干涉信号；分析处理装置(140)，其中，所述分析处理装置(140)适用于接收由至少第一检测器(121)和第二检测器(122)响应于所确定的自混合干涉信号而产生的检测信号，其中，所述分析处理装置(140)还适用于通过在预定的时间段内接收到的检测信号来确定由所述第一检测器(121)检测到的颗粒的至少第一平均速度和由所述第二检测器(122)检测到的颗粒的至少第二平均速度，其中，所述分析处理装置(140)还适用于基于由所述第一检测器(121)在预定的时间段内提供的检测信号来确定颗粒的至少第一数量并且基于由所述第二检测器(122)在预定的时间段内提供的检测信号来确定颗粒的至少第二数量，其中，所述分析处理装置(140)还适用于基于平均颗粒速度来确定颗粒密度，所述平均颗粒速度至少通过所述第一平均速度和所述第二平均速度、所述颗粒的至少第一数量和所述颗粒的至少第二数量来确定。本发明还涉及一种颗粒密度检测的方法和一种相应的计算机程序产品。本发明还涉及一种包括这样的激光传感器模块(100)的移动通信装置(190)。

Device for real-time analysis of particles suspended in a fluid and method for analyzing said particles

本发明涉及一种用于分析颗粒的装置，其包括被配置为容纳定位流体的分析室。利用检测和控制单元来检测悬浮在定位流体中的颗粒的参数。在颗粒分析操作期间，基于所检测到的颗粒的参数来启用和停用定位单元。检测和控制单元可以启用至少一个定位单元以在定位流体中产生临时定位流，使得所述临时定位流直接作用于颗粒并且驱动颗粒的位置以使该颗粒移动到分析室内的预定义位置。在待分析颗粒处于预定义位置的情况下，检测和控制单元还可以停用至少一个定位单元，使得定位流体静止。

Microfluidic determination of heterogeneous objects

Provided are microfluidic systems and methods for detecting and sorting of droplets comprising heterogeneous particulate objects such as single cells and non-cell particles, including a variety of eukaryotic and bacterial cells, for a variety of bioassay applications. The systems and methods described herein, when implemented in whole or in part, will make relevant microfluidic based tools available for a variety of applications in biotechnology including antibody discovery, immuno-therapeutic discovery, high-throughput single cell analysis, target-specific compound screening, and synthetic biology screening.

Systems, apparatus, and methods for sorting particles

本发明提供的是与流体中的颗粒和细胞分选以及检测有关的细胞检测系统、流体装置、结构以及技术，例如分选特定亚群的细胞类型。用于验证颗粒分选的方法包括：接收与在第一通道中的颗粒的光学特性相关联的第一检测信号。基于第一检测信号来确定多个第二通道的分选通道，由此基于颗粒的光学特性确定将颗粒分选进入分选通道。传输用于将颗粒从第一通道分选进入分选通道中的分选信号。第二检测信号被接收，其与在分选通道中颗粒的存在相关联。基于第二检测信号，验证颗粒从第一通道中分选进入分选通道中。

Method for determining particle velocity of aerosol and aerosol measuring device

本发明涉及一种用于借助于气溶胶测量仪确定气溶胶的微粒速度的方法。气溶胶‑微粒流动通过测量室并且利用电磁射束照射。由传感器接收并检测散射光。确定散射光信号的在时间上的信号持续时间并且根据所述信号持续时间确定气溶胶的微粒速度。此外，本发明规定一种用于确定气溶胶的微粒速度的气溶胶测量仪，所述气溶胶测量仪构造为用于实施按照本发明的方法的步骤。此外，规定一种具有程序代码段的计算机程序，所述计算机程序设计为用于实施按照本发明的方法的步骤。

Methods and apparati for nondestructive detection of undissolved particles in a fluid

本公开涉及非破坏性地检测流体中未溶解的颗粒的方法和装置。此处公开的装置、方法和计算机程序产品可用于非破坏性检测器皿中的流体中的诸如玻璃鳞片和/或蛋白质聚集体之类的未溶解颗粒，所述流体包括但不限于包含药物的流体。

Passive wireless multi-stage droplet micro-fluidic detection device

本发明公开了一种无源无线的多级液滴微流控检测装置，其中：一级电感通道与二级电感通道均包括两层电感线，每层一级电感通道的电感线与二级电感通道的电感线相间设置；液态导电材料注入后，形成双谐振电路；检测通道，第一部分设置于一级电容通道之间；第二部分设置于二级电容通道之间；读取器件，用于读取双谐振电路的谐振频率，并依据谐振频率检测得到对应的第一液滴组或/和第二液滴组的信息。采用上述方案，采用非接触方式在单次检测方案中读取谐振频率，依据谐振频率实现对多级液滴的检测，可以大幅度缩小检测装置的体积，延长装置使用寿命，以及保证整体上的检测结果的准确度，并扩大检测装置的应用领域。

It is a kind of to be used for the measuring system of electrically conductive particles and electrode collision coefficient in GIS

本发明属于电气测量技术领域，尤其涉及一种用于GIS中导电微粒与电极碰撞系数的测量系统，包括：竖立与底板坐标上的支撑架，支撑架上端设置有由夹具控制电机控制的微粒夹具，微粒夹具夹持待测的导电微粒，微粒夹具正下方设置有角度可调的碰撞铜板，底板坐标上涂抹有黄油，用于准确判断微粒落地点；微粒夹具端部有夹具软垫，微粒夹具的张开尺寸通过夹具控制电机调整，夹具控制电机通过电机遥控控制；所述碰撞铜板通过铜板调节销与所述支撑架相连接，铜板调节销上安装有量角器能准确测量出所述碰撞铜板与水平方向的角度；所述支撑架上安装有测距装置固定杆，测距装置固定杆上安装有红外测距装置，用于测量测量微粒与铜板调节销的竖直方向距离。

Device and method for measuring concentration, size and Z potential of liquid nanoparticles in scattered light mode and fluorescence mode

本发明涉及一种用于在散射光模式和荧光模式下测量液体中纳米颗粒的浓度、尺寸和Z电位的装置和方法，包括以下特征：a)样品(28)从上方被激光光束通过分光器(14)和可调焦点液体透镜(9)而照射，且光的反射光束通过相同的分光器(14)和另一液体透镜(8)而被偏转至检测器(5)并被分析；b)为了观察荧光的目的，荧光滤光片(19)被连接至所述液体透镜(8)和所述检测器(5)之间的会聚光束路径中，用来增加散射光平面(31)和荧光平面(30)之间的距离；以及c)为了控制所述测量过程，使用颗粒跟踪程序、光学控制器(15)和具有触控屏幕的显示器(2)。

Particles counting apparatus and method having improved particle sizing resolution

A particle counter (10) passes a sample stream of particles (72) through an elongated, flattened nozzle (16) and into a view volume (18) formed by an intersection of the sample stream and a laser beam (13). Scattered light (24) from the view volume is focused onto a linear array (32) of photodiode detectors (40) positioned such that a longitudinal length (70) of the view volume is imaged on the detectors. Because the sample stream produces nonuniform particle velocities along the longitudinal dimension of the view volume, for same-sized particles higher velocity particles will generate lower output amplitude signals than lower velocity particles. Therefore, the gain associated with each photo-detector element is adjustable to compensate for the nozzle velocity differences, laser beam intensity differences caused by beam divergence and fluctuations, optical path efficiency variations, and photo-detector element-to-element sensitivity differences.

Characterization of motion-related error in a stream of moving micro-entities

描述了用于检测和表征移动微实体的运动相关误差的设备和方法。运动相关误差可出现在移动微实体的流中，并且可表示期望到达时间的偏差或微实体位置的不确定性。在流式细胞计中观测到的微实体的运动相关误差，例如为脉冲抖动，并且被发现具有与关于系统时钟的参数的函数相关性。可通过关联在流体流中移动的微实体的测量结果来表征运动相关误差。

Line excitation array detection microscopy

Disclosed herein are systems and methods for line excitation array detection (LEAD) microscopy. The systems and methods include an excitation beam from an optical beam source and a subject of interest. Light is scanned across the subject of interest and optical signals are detected using a parallel optical detection means. A number of mechanical, acoustic and or optical components such as scanning mirrors, DMDs, OADs, electric motors may be used in separately or in conjunction to aid in the scanning of the excitation beam across the subject of interest

Methods and apparati for nondestructive detection of undissolved particles in a fluid

METHODS AND APPARATI FOR NONDESTRUCTIVE DETECTION OF UNDISSOLVED PARTICLES IN A FLUID The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel (10), such as, but not limited to, a fluid that contains a drug. -700

SYSTEMS AND METHODS FOR DIAGNOSTIC SYSTEMS FOR SUBMITTING FLUIDS AND DETERMINING DATA PROCESSING SETTINGS FOR A FLOW CYTOMETER

Detection and/or registration of non-liquid particles in liquid stream

Home testing device

Изобретение относится в целом к оптическому контролю образцов, в частности к автоматизированным способам и устройствам для захвата и анализа электронных изображений образцов. Заявленное оптическое устройство содержит корпус, конфигурированный для надевания поверх по меньшей мере части мобильного вычислительного устройства, имеющего первую и вторую поверхности и содержащего источник света, испускающий световой луч через выходное отверстие и направляющий световой луч в направлении от второй поверхности мобильного вычислительного устройства, и модуль камеры, захватывающий изображения через входное отверстие. Причем как входное, так и выходное отверстия открываются на второй поверхности мобильного вычислительного устройства. Также оптическое устройство содержит приемную часть в корпусе, конфигурированную для приема и расположения образца вблизи второй поверхности мобильного вычислительного устройства в пределах поля обзора модуля камеры, и оптико-осветительную систему, конфигурированную для приема и поворота луча, испускаемого источником света. Оптико-осветительная система содержит пару отражающих поверхностей, каждая из которых конфигурирована для поворота луча на 90° и каждая из которых конфигурирована отражать луч обратно в направлении ко второй поверхности мобильного вычислительного устройства так, чтобы подсветить образец сзади, в то время как модуль камеры захватывает одно или более изображений подсвеченного сзади образца. Технический результат – обеспечение возможности тестирования семенной жидкости в домашних условиях на любой стадии. 3 н. и 18 з.п. ф-лы, 7 ил.

Drift tube field driving system and method

An apparatus for generating high voltage (HV) driving signals associated with an ion mobility detector comprises a ground-based HV base module and a HV deck module coupled by an interconnect module. The HV base module implements dual power supplies that together drive a drift tube voltage signal to the high-voltage-based deck module. Each of the power supplies is regulated by a combination open loop and closed loop controller. The HV deck module implements one or more grid modules that generate a bipolar voltage that floats on the drift tube voltage signal. Also included may be a pulse generator configured to generate at least one synchronizing timing pulse. Power supplies within the apparatus may be synchronized based on the synchronization timing pulse.

Dielectrophoretic particle profiling system and method

A system for performing dielectrophoretic analysis on a population of particles, the system comprising: a chamber (150) having a well; a plurality of electrodes disposed on the wall of the chamber; a function generator (140) configured to supply an AC at a plurality of frequencies to the plurality of electrodes; a detector (120) configured to acquire images of a sample disposed in the chamber; and an electronic controller (130) in electrical communication with the detector (120).

Method and apparatus for particle length measurement

1450712 Analyzing particles electrically COULTER ELECTRONICS Ltd 6 Nov 1973 [6 Nov 1972] 51530/73 Heading G1N In the determination of the length of long particles (three times the length of the aperture) by means of a Coulter-type apparatus the length of each particle produced pulse is measured at the same specific percentage of its maximum amplitude. The measurements made in this way are independent of differing particle cross-sections. In one embodiment, Fig. 4 (not shown) the particle pulses generated are passed to a threshold circuit the output of which is fed to a gate circuit to which a reference voltage is also fed whereby a constant amplitude (reference voltage) pulse is produced the duration of which corresponds to the period during which the amplitude of the respective particle pulse exceeds the threshold level set by the threshold circuit. The constant amplitude pulses are then integrated and the resultant ramp signal applied to a pulse height analyzer, the output from which gives the length of the particle. In order to compensate for velocity changes due to different lengths of particles a non-linear function can be built into the analyzer. The setting of the threshold circuit to the required percentage level depends upon the manner by which the maximum amplitude of each pulse is ascertained. If prior to analyzing it is known that all the particles in the sample suspension have the same cross-section, generating pulses having the same maximum amplitude which is of known value then the threshold circuit is merely set to give the required percentage value of this. If the level is other than 50% then the final value of particle length has to be suitably modified. In the case where the particles are known to be of the same cross-section but generating unknown amplitude pulses then the maximum amplitude can be determined using a portion of the sample prior to the analysis or instead of actually making a measurement the output from the threshold circuit, set ...

Planar particle/droplet size measurement technique using digital particle image velocimetry image data

A method for determining a mass flux of an entrained phase in a planar two-phase flow records images of particles in the two-phase flow. Respective sizes of the particles (the entrained phase) are determined as a function of a separation between spots identified on the particle images. Respective velocities of the particles are determined. The mass flux of the entrained phase is determined as a function of the size and velocity of the particles.

MULTI-CHANNEL DUST SENSOR

Optical particle counter

微粒子撮影装置及び流速計測装置

【課題】コンパクトな照明光学系を有する粒子撮影装置及びこれを用いた流速計測装置を提供する。【解決手段】粒子撮像素子１は、プローブ部５と、プローブ部５にレーザ光を導入する光ファイバ７と、レーザ光により照明される粒子を撮像する撮像部６とを備える。プローブ部５は、光ファイバ７からのレーザ光に基づいて粒子をシート状の照明光で照明する照明光学系１３と、光ファイバ７の端部と照明光学系１３との間の距離を変更する調整部１４とを備える。【選択図】図２

Biological sample analysis system, information processing device, information processing method, and biological sample analysis method

A clearer image is acquired while redundancy of analysis time is suppressed. A biological sample analysis system according to an embodiment includes: an irradiation unit (101) that irradiates a bioparticle in a biological sample with light; a detection unit (102) including a plurality of pixels that each detects, as an event, a luminance change of light emitted from the bioparticle by irradiation with the light; and a processing unit (103) that generates bioparticle information regarding the bioparticle on the basis of the event detected by each of the pixels.

Automated holographic video microscopy assay

An in-line holographic microscope can be used to analyze a video stream to track individual colloidal particles' three-dimensional motions. The system and method can provide real time nanometer resolution, and simultaneously measure particle sizes and refractive indexes. An assay using the holographic microscope for holographic particle characterization directly detect viruses, antibodies and related targets binding to the surfaces of specifically functionalized micrometer-scale colloidal probe beads. The system detects binding of targets by directly measuring associated changes in the bead's diameter without the need for downstream labeling and analysis.

光学式のパティキュレートセンサ、特に排ガスセンサ

本発明は、測定ガスの流れ内のパティキュレートを検出する、特にバーナまたは内燃機関の排ガス通路内の煤粒子を検出するパティキュレートセンサであって、レーザ光（１０）の発生手段または供給手段と、レーザ光（１０）の合焦手段と、熱放射線の検出手段または伝搬手段と、を備え、パティキュレートセンサ（１６）は、少なくとも１つの光学的な入口（４０）を有し、この光学的な入口（４０）は、測定ガスにさらされる領域（１６.１）を、測定ガスとは反対側の、測定ガスにさらされない領域（１６.２）から分離しており、レーザ光（１０）の発生手段または供給手段および／または熱放射線の検出手段または伝搬手段は、測定ガスとは反対側の領域（１６.２）に配置されている、パティキュレートセンサにおいて、パティキュレートセンサ（１６）は、測定ガス流から部分流（３２１）を取り出し、レーザ焦点（２２）に供給し、さらに、光学的な入口（４０）を部分流（３２１）に対して流体的に遮蔽することを特徴とする、パティキュレートセンサ。

静电可控磨粒流加工去除量检测装置与检测方法

本发明公开了一种静电可控磨粒流加工去除量检测装置及检测方法，包括磨粒流加工装置、法拉第筒法系统和显微可视化系统，所述磨粒流加工系统包括高压静电发生器、配模吸附平台、外加电场、磨粒流和工件，工件通过配模吸附平台进行固定，磨粒流经过高压静电发生器后发射到工件表面进行磨粒流加工，外加电场直接加载在整个配模吸附平台和工件上；本发明提出适用于电荷尖端聚集效应的静电可控磨粒流加工方法经验预测模型方程，通过法拉第筒系统设计解决了磨粒的带电电荷量测量的相关，为选择合适磨粒与工件的切削作用力提供理论依据。

System and method for pneumatic-free electronically driven microfluidics to allow massive scalability with integrated cellular and biomolecular detection

According to various embodiments, a microfluidic bio-sensing system is disclosed. The system includes at least one semiconductor chip configured to control at least one of electrokinetic fluid flow, cell manipulation and sensing, and bio-molecular sensing by utilizing at least one plurality of electrodes in a microfluidic channel. The bio-sensing system is applicable to general bio-molecular and cell-based diagnostics in a battery-powered hand-held ultra-compact packaging without requiring any external instrumentations, allowing for the elimination of pneumatic pumps.

异质物体的微流体测定

提供了用于检测和分选液滴的微流体系统和方法，所述液滴包括异质颗粒物体，例如单细胞和非细胞颗粒，包括各种真核细胞和细菌细胞，用于各种生物测定应用。本文描述的系统和方法在全部或部分地实现时将使得相关微流体工具可用于生物技术中的多种应用，包括抗体发现、免疫治疗发现、高通量单细胞分析、靶特异性化合物筛选和合成生物筛选。

Support pour l'analyse par microscope d'une substance biologique à base liquide et système comportant un tel support et un microscope

Le support comporte une lame porte-objet (11) et une lamelle couvre-objet (12) assujetties par des lignes de colle (13) délimitant périphériquement des compartiments individuels (14) de réception d'un échantillon de ladite substance biologique; caractérisé en ce que la face supérieure (17) de la lame porte-objet est à nu et à découvert sur au-moins une région marginale avant (41) et au-moins une région marginale arrière (42), ayant chacune une extension suivant la direction avant-arrière au-moins égale à 2,5 mm et une extension suivant la direction gauche-droite au moins égale à l'écart entre les axes respectifs des deux compartiments individuels les plus éloignés l'un de l'autre. Le système comporte le support (40) et un microscope configuré pour enserrer le support entre une platine et une plaque d'appui pourvue de doigts dont les extrémités distales sont au contact des régions marginales (41, 42) exclusivement.

Microfluidic impedance cytometry apparatus

A microfluidic impedance cytometry apparatus, for position determination and impedance measurement of particle/s in a fluid carrying particles, comprising: a microfluidic impedance flow channel for allowing flow of said fluid; an upstream section; a downstream section; a sensing region to receive said channeled fluid, to sense one or more parameters of said fluid, said sensing region comprising one or more sets of pairs of electrodes, each pair forming a current path from an operative top to an operative bottom, each of said pairs being formed by an operative top electrode and an operative bottom electrode, electric potential being applied on said operative top electrode/s, each electrode for a particular pair being parallel-aligned and being symmetric, with respect to each other, same positive electric potential being applied on each of said top electrodes and each of said bottom electrodes is virtually grounded, for a pair; and a configuration of amplifiers.