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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 1078. Отображено 100.
26-01-2012 дата публикации

Belt Agitation System For Culture Bottles

Номер: US20120021452A1
Автор: James C. Bishop
Принадлежит: Biomerieux Inc

A specimen culture container agitation assembly includes an endless belt having a multitude of container-receiving clips attached thereto, each of which is adapted for retaining a specimen culture container to the belt. The belt is oriented vertically. The assembly further includes upper and lower pulleys over which the belt is driven. A drive motor drives the belt around the pulleys. Agitation of the specimen culture container is achieved by rotation of the belt over the pulleys and the retaining of the specimen culture container by the clip.

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Номер записи: 1
06-03-2014 дата публикации

Sample processing apparatus and sample processing method

Номер: US20140064019A1
Автор: Takaaki Nagai, Yuuichi Hamada
Принадлежит: Sysmex Corp

A sample processing apparatus comprising a controller; an agitating section configured to agitate a sample in a sample tube; and a processing section configured to process the agitated sample, wherein the controller is configured to control the agitating section to agitate a sample in a first type of sample tube under a first agitation condition, and to control the agitating section to agitate a sample in a second type of sample tube, which contains a sample of lower volume than the first type of sample tube, under a second agitation condition different from the first agitation condition.

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Номер записи: 2
02-01-2020 дата публикации

EVAPORATION-CONTROLLING CONTAINER INSERTS

Номер: US20200001258A1
Автор: Knight Byron J.
Принадлежит: GEN-PROBE INCORPORATED

An apparatus configured for mixing the contents of one or more fluid containers includes a fluid container support platform configured to hold one or more fluid containers. The fluid container support platform is configured to index the container to one or more specified locations and to be moved in an orbital path about an orbital center independently of the rotation about the central axis of rotation. The apparatus further includes an indexing drive system configured to effect indexing movement of the container support platform and a vortex drive system configured to effect powered orbital movement of the container support platform about the orbital center. An evaporation limiting insert placed within containers reduces exposure of the fluid contents of the container to atmospheric air, thereby reducing susceptibility of the fluid contents to evaporation. 1. A method for removing fluid contents of a container while minimizing evaporation of the fluid contents from the container , the method comprising:a) inserting an evaporation-limiting insert into an opening of a neck of the container, the evaporation-limiting insert comprising a hollow tubular body configured to extend into the container from the neck of the container, the tubular body including a plurality of holes formed through a wall of the tubular body and distributed along at least a portion of the length of the tubular body, andb) after step a), inserting a portion of a fluid transfer apparatus through the opening of the container and into the tubular body of the evaporation-limiting and withdrawing a portion of the fluid contents from the container with the fluid transfer apparatus.2. The method of claim 1 , wherein the fluid transfer apparatus comprises a robotic pipettor claim 1 , and step b) comprises inserting a pipette tip associated with the robotic pipettor through the opening of the container and into the tubular body of the evaporation-limiting insert and aspirating a portion of the fluid ...

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Номер записи: 3
14-01-2021 дата публикации

EVAPORATION-LIMITING INSERTS FOR REAGENT CONTAINERS AND RELATED METHODS OF USE

Номер: US20210008561A1
Автор: CHABOT Vincent, Knight Byron J.
Принадлежит: GEN-PROBE INCORPORATED

An insert for a liquid-holding container may include a body comprising a wall, an open top end and a bottom end, and a generally tubular lumen extending from the open top end to the open bottom end. The insert may include a plurality of first openings formed in the wall, the first openings being situated between the top and bottom ends, wherein each of the plurality of first openings defines an area, and wherein the plurality of first openings have substantially the same dimensions. The insert may include one or more second openings formed in the wall, the one or more second openings being situated between the top and bottom ends, wherein each of the one or more second openings defines an area that is greater than the area defined by any of the first openings, wherein the one or more second openings have substantially the same dimensions. 1110-. (canceled)111. An insert for a liquid-holding container , the insert comprising:a body comprising a wall, an open top end and a bottom end, and a generally tubular lumen extending from the open top end to the open bottom end;a plurality of first openings formed in the wall, the first openings being situated between the top and bottom ends, wherein each of the plurality of first openings defines an area, and wherein the plurality of first openings have substantially the same dimensions; andone or more second openings formed in the wall, the one or more second openings being situated between the top and bottom ends, wherein each of the one or more second openings defines an area that is greater than the area defined by any of the first openings, wherein the one or more second openings have substantially the same dimensions, wherein at least one of the one or more second openings is situated closer to the top end than any of the plurality of first openings, and wherein each of the first and second openings is sized to permit the passage of a liquid.112. The insert of claim 111 , wherein a thickness of the wall immediately ...

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Номер записи: 4
10-01-2019 дата публикации

SAMPLE CONTAINER HANDLING WITH AUTOMATED CAP REMOVAL/REPLACEMENT AND DRIP CONTROL

Номер: US20190011473A1
Автор: BUSE DAVID Aaron, Capella Richard, MERTEN Matthias, OPALSKY David, ROSATI ROBERT J., SILBERT Rolf, TAMMER OLEV
Принадлежит: GEN-PROBE INCORPORATED

A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and a drip tray movable between a first position not under the capping/decapping mechanism and a second position under the capping/decamping mechanism. 1. A processing station for automatically processing a biological sample , comprising:(a) a rotatable platform configured to rotate around a central axis of rotation;(b) two or more container holders arranged in spatially distinct locations on the rotatable platform, wherein each of the container holders is configured to rotate about a secondary axis of rotation that is associated with that container holder and is radially spaced from the central axis of rotation;(c) a capping/decapping mechanism configured to cap and decap a container held in one of the container holders positioned below the capping/decapping mechanism and comprising a chuck configured to grasp a cap of a container and an elevator configured to move the chuck between a lowered position and a raised position with respect to the container; and(d) a drip tray configured to be movable between a first position not under the chuck and a second position under the chuck when the chuck is moved to the raised position by the elevator.2. The processing station of claim 1 , wherein the drip tray is configured to translate between the first position and the second position in a radial plane relative to the central axis.3. The processing station of claim 1 , wherein the drip tray is rotatable between the first position and the second position about a tertiary axis that is different than the central axis of the rotatable platform.4. The processing station of claim 3 , wherein the drip tray is disposed on an arm claim 3 , post claim 3 , plate claim 3 ...

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Номер записи: 5
26-01-2017 дата публикации

APPARATUS FOR THE AUTOMATIC PERFORMANCE OF IMMUNOHAEMATOLOGY ANALYSIS ON GEL CARDS

Номер: US20170023561A1
Автор: MARTINELL GISPERT-SAUCH ENRIQUE, PUIG CEBRIA JORDI
Принадлежит:

The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control. 1. An apparatus for automatic immunohaematological analysis on gel cards , wherein the apparatus comprises:a) a containing body with a flat functional upper floor for containing receptacles of reagents, diluents and samples, as well as housings for the gel cards and their incubators;b) a lower floor carrying receptacles for washing liquids and for collection of waste and cards, and for housing a fluidic and electronic control system;c) a set of longitudinal and transverse guides associated with an upper part of the apparatus, suitable for carrying in suspension moving heads of the apparatus, which are movable on the transverse guides;d) two heads, respectively for perforating and pipetting and for transporting the cards;e) two centrifuges and a gel card reader; andf) a folding information and control touch screen.2. The apparatus according to claim 1 , wherein the flat functional upper floor is comprised of a single working level for all tasks claim 1 , having on one of its sides elements relating to reagents claim 1 , diluents claim 1 , samples and a dilution well claim 1 , and on its other side card drawers claim 1 , accesses to centrifuges claim 1 , access to the card reader claim 1 , and access to a bin for scrap ...

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Номер записи: 6
30-01-2020 дата публикации

Methods, Devices, and Apparatus for Washing Samples on Array Plates

Номер: US20200032189A1
Автор: Cheng Kong Leong, Kim Namyong
Принадлежит:

A method for washing particles includes obtaining an array plate that includes an array of hydrophilic areas surrounded by one or more hydrophobic areas. A respective solution containing a sample is located on a respective hydrophilic area of the array of hydrophilic areas. The respective hydrophilic area includes one or more indentations from a respective surrounding hydrophobic area of the one or more hydrophobic areas. The respective hydrophilic area includes a first indented surface that is offset from a reference surface defined by the respective surrounding hydrophobic area. The method also includes placing an aspirator nozzle above the respective hydrophilic area at a predefined distance from the first indented surface, and aspirating the solution with the aspirator nozzle while the aspirator nozzle is located at the predefined distance from the first indented surface. 1. An apparatus for washing an array plate , comprising:one or more dispensers, a respective dispenser of the one or more dispensers configured to dispense a first liquid on the array plate; andone or more aspirators that are distinct from the one or more dispensers, a respective aspirator of the one or more aspirators configured to aspirate liquid on the array plate.2. The apparatus of claim 1 , wherein: a first piston configured to slide at least partially within a first channel; and', 'a first valve configured to allow the first liquid in the first channel to be dispensed from the first channel through the first valve and prevent a liquid from entering into the first channel through the first valve., 'the respective dispenser includes3. The apparatus of claim 2 , wherein:the respective dispenser includes a first tube defining at least a portion of the first channel and configured for holding the first liquid; andthe first piston is slidably coupled with the first tube.4. The apparatus of claim 3 , wherein:the respective dispenser also includes a second valve that is distinct from the first ...

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Номер записи: 7
12-02-2015 дата публикации

DEVICE AND METHOD FOR CONTROLLING THE TEMPERATURE IN A MOVING FLUID IN A LABORATORY SAMPLE PROCESSING SYSTEM

Номер: US20150044664A1
Автор: KELLAND James, Nguyen Nhat Khai L., SULLIVAN Kevin J.
Принадлежит:

A temperature control device and method are provided for an analytical system for performing laboratory protocols. The device includes a well within a housing configured to receive a biological specimen according to a predetermined sample process. The specimen is suspended by a holding device in the well. A thermal element is provided in heat exchange communication with fluid in the well. A temperature sensor is located in the well at a location to be covered and uncovered by rocking motion of fluid in the well. A controller, in communication with the thermal element, the temperature sensor, and an agitation system, is operative to control the thermal element in correlation with temperature data, for example, peak temperature data, from the temperature sensor. 1. A temperature control device comprising:a housing, a well within the housing configured to receive an object, at least one fluid port in the housing configured to provide fluid access to the well;a thermal element in heat exchange communication with fluid in the well;a temperature sensor disposed in the well at a location to be covered and uncovered by fluid in the well as the housing portion moves;an agitation system coupled to at least a portion of the housing to cause fluid flow within the well; anda controller in communication with the thermal element, the temperature sensor, and the agitation system and operative to control the thermal element in correlation with temperature readings from the temperature sensor and movement of the agitation system.2. The device of claim 1 , wherein the thermal element comprises a surface of the housing forming a portion of the well.3. The device of claim 1 , wherein the thermal element is thermally coupled to a surface of the housing.4. The device of claim 1 , wherein the thermal element is thermally coupled to a floor of the well.5. The device of claim 1 , wherein the thermal element comprises a Peltier device thermally coupled to a surface of the housing.6. The ...

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Номер записи: 8
03-03-2022 дата публикации

Automated method for direct sampling of immune cells from whole blood or other biological samples in microwell plates

Номер: US20220065879A1
Автор: BARNES Stephen, LIU Zhaoping, PEREZ Dominique, SUSKI Christopher
Принадлежит:

A method for automatic sampling of immune cells from a biological fluid sample, e.g., whole blood, deposited in a well of a microwell plate. The sample contains red blood cells (RBCs) and magnetic beads which are designed to bind to the RBCs. The microwell plate is placed on a shaker having a magnetic adapter including at least one magnet. The magnet causes the RBCs bound to the magnetic beads to be attracted to and migrate to a wall of the well (e.g., the bottom or side wall) and be held against the wall. The shaker is then operated to shake the microwell plate in a manner and for a time period so as to suspend substantially evenly or homogeneously the immune cells in the biological fluid sample within a region of the well but still retain the holding of the RBCs to the wall of the well such that the immune cells are substantially isolated from the RBCs in the region of the well. During or after shaking, a sample probe is then lowered into the region of the well to withdraw a portion of the sample containing the immune cells. 1. A method for automatic sampling of immune cells from a biological fluid sample deposited in a well of a microwell plate , the well having a wall , the biological fluid sample containing (1) red blood cells (RBCs) and (2) magnetic beads which are designed to bind to the RBCs in the sample , comprising the steps of:a) placing the microwell plate on a shaker having a magnetic adapter including at least one magnet, wherein the magnet causes the RBCs bound to the magnetic beads to be held against the wall of the well;b) shaking with the shaker the microwell plate in a manner and for a time period so as to suspend substantially evenly the immune cells in the biological fluid sample within a region of the well such that the immune cells are substantially isolated from the RBCs held against the wall of the well; andc) lowering a sample probe into the well in the region of the well and withdrawing a portion of the sample containing the immune cells ...

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Номер записи: 9
14-02-2019 дата публикации

CONTINUOUS PROCESS FOR PERFORMING MULTIPLE NUCLEIC ACID AMPLIFICATION ASSAYS

Номер: US20190049378A1
Автор: DAVIS Christopher B., HEINZ Robert E., Knight Byron J., LAIR Gary D., LI Florence, Li Haitao, MACIOSZEK Jerzy A., NGUYEN Thanh N., SCALESE Robert F.
Принадлежит:

A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures. In the method, a first plurality of reaction mixtures are provided to a heater and subjected to conditions for performing a first amplification reaction. The presence or amount of a first target nucleic acid in each of the first plurality of reaction mixtures is determined during the first amplification reaction. During the first amplification reaction, a second plurality of reaction mixtures are provided to the heater and subjected to conditions for performing a second amplification reaction. The presence or amount of a second target nucleic acid in each of the second plurality of reaction mixtures is determined during the second amplification reaction. At least a portion of the second plurality of reaction mixtures are removed from the heater during the second amplification reaction. 1. (canceled)2. A method of determining the presence or amount of a target nucleic acid in each of a plurality of reaction mixtures , the method comprising the automated steps of:a) providing a first plurality of reaction mixtures to a heater disposed on a generally horizontal work surface of an analyzer having a window situated above the work surface, wherein each reaction mixture of the first plurality of reaction mixtures is suspected of containing a first target nucleic acid, and wherein each reaction mixture of the first plurality of reaction mixtures contains reagents sufficient to perform a first nucleic acid amplification reaction with the first target nucleic acid;b) in the heater, subjecting each reaction mixture of the first plurality of reaction mixtures to conditions sufficient to perform the first nucleic acid amplification reaction;c) determining the presence or amount of the first target nucleic acid in each reaction mixture of the first plurality of reaction mixtures during the first nucleic acid amplification reaction;d) during steps b) and c), ...

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Номер записи: 10
10-03-2016 дата публикации

Devices, systems and methods for sample preparation

Номер: US20160069916A1
Автор: Alexander Loo, Elizabeth A. Holmes
Принадлежит: Theranos Inc

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

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Номер записи: 11
29-03-2018 дата публикации

PERFORMING ANTIMICROBIAL SUSCEPTIBILITY TESTING AND RELATED SYSTEMS AND METHODS

Номер: US20180088141A1
Автор: Hayes Rohan, Otten Paul, Passernig Anna, Purmort Nathan, Richardson Bruce, Stern Eric, Tragni Randy, Tsupryk Andriy, Vacic Aleksandar
Принадлежит:

In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells. 1. An automated rapid antimicrobial susceptibility testing system for performing a multi-assay testing sequence , the system comprising: 'one or more agitation systems configured to generate a repeated motion of the nest assemblies;', 'one or more automated incubation assemblies comprising a nest assembly adapted to: i) house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, and ii) facilitate incubation of one or more test panels in order to undergo the multi-assay testing sequence, the incubation assembly comprisinga sample separation assembly configured to separate microorganisms from a remainder of the sample within the wells of test panel, the sample separation assembly comprising a centrifugation system that forms a pellet of the microorganisms within the wells of the test panels;a robotic handling assembly configured to accept one or more incoming test panels and move them between at least one of the one or more automated incubation ...

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Номер записи: 12
19-06-2014 дата публикации

Dispensing apparatus, analyzer and method for controlling dispensing apparatus

Номер: US20140170026A1
Автор: Eriko Matsui, Hatsume Uno, Shinsuke Haga, Teppei Toyoizumi
Принадлежит: Sony Corp

There is provided a dispensing apparatus including a dispensing unit; and a drive mechanism. The dispensing unit is configured to support a dispensing nozzle, provide the dispensing nozzle with a material to be dispensed, and allow the dispensing nozzle to discharge the material. The drive mechanism is configured to change relative position between a stage and the dispensing nozzle in a second direction and a third direction, where the second direction is a horizontal direction when a first direction is substantially vertical direction, and the third direction is substantially perpendicular to the first direction and to the second direction.

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Номер записи: 13
06-04-2017 дата публикации

APPARATUS AND METHOD FOR PROCESSING AT LEAST ONE SAMPLE

Номер: US20170097370A1
Автор: Steinert Chris
Принадлежит:

A method and apparatus for processing a sample is presented. The apparatus comprises a chamber, a first input for inputting a first vessel into the chamber, a second input for inputting a second vessel into the chamber, the second input is different from the first input, a rotor comprising a first compartment for receiving the first vessel and a second compartment for receiving the second vessel, a gripper to grip the first vessel and to transport the first vessel to the first compartment, and a pipettor to pipette a sample from the first vessel and/or second vessel. The rotor rotates between a first position where the first vessel is transportable to the first compartment by the gripper, a second position where the second vessel is loadable into the second compartment, and a third position where the sample of the first vessel and/or second vessel is aspiratable by the pipettor. 1. An apparatus for processing at least one sample , the apparatus comprising:a processing chamber;a first input for inputting at least a first vessel into the processing chamber;a second input for inputting at least a second vessel into the processing chamber, wherein the second input is different from the first input;a rotor comprising at least a first compartment for receiving the first vessel from the first input and a second compartment for receiving the second vessel from the second input;a gripping device adapted to at least grip the first vessel and to transport the first vessel from the first input to the first compartment of the rotor; anda pipetting device adapted to at least pipette a sample from the first vessel and/or the second vessel, wherein the rotor is rotatable at least between a first processing position, at which the first vessel is transportable to the first compartment of the rotor by the gripping device, a second processing position, at which the second vessel is loadable into the second compartment of the rotor from the second input, and a third processing position, ...

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Номер записи: 14
13-05-2021 дата публикации

BEAD BEATING TUBE AND METHOD FOR EXTRACTING DEOXYRIBONUCLEIC ACID AND/OR RIBONUCLEIC ACID FROM MICROORGANISMS

Номер: US20210139952A1
Автор: KLAPPROTH Holger, SMIT Nicolaas
Принадлежит: Safeguard Biosystems Holdings Ltd.

The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids. 1. A method for producing a lysate from cells contained in a liquid sample , comprising agitating the liquid sample within a bead beating system in the absence of lysis buffer and in the presence of one or more blocking agents under conditions sufficient to lyse the cells , said bead beating system comprising a bead beating tube and beads.2. The method of claim 1 , wherein the liquid sample contains an endogenous blocking agent.3. The method of claim 2 , wherein the agitating is carried out in the absence additives.4. The method of claim 1 , wherein the one or more blocking agents are exogenous to the liquid sample.5. The method of claim 2 , wherein the beads:a) are adapted to lyse bacteria, yeast, filamentous fungi, spores, plant cells, or animal cells; i. mineral beads, ceramic beads, glass beads, metal beads, or a combination thereof;', 'ii. zirconium beads, zircon beads, zirconia beads, quartz beads, aluminum oxide beads, silicon carbide beads, ceramic beads, silicon dioxide glass beads, stainless steel beads, chrome steel beads, or a combination thereof;', 'c) have a diameter ranging from 50 μm to 3 mm; or', 'd) any combination of a)-c)., 'b) comprise6. The method of claim 1 , further comprising a step of placing the liquid sample within the sample tube prior to agitating the liquid sample.7. The method of claim 1 , wherein the agitating comprises subjecting the bead beating system to an oscillating motion.8. The method of claim 1 , wherein the sample is a biological sample claim 1 , an environmental sample claim 1 , or a food product.9. The method of claim 8 , wherein the sample is a biological sample selected from blood claim 8 , serum claim 8 , saliva claim 8 , ...

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Номер записи: 15
05-05-2016 дата публикации

Method for detecting the presence of a nucleic acid in a sample

Номер: US20160122808A1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample.

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Номер записи: 16
24-07-2014 дата публикации

Automatic Genechip Array Diagnosing Apparatus

Номер: US20140206571A1
Автор: Chan-Han Wu, Hui-Jen CHANG, Shiu-Ru Lin, Suz-Kai Hsiung
Принадлежит: Fooyin University Hospital

A method of diagnosing a sample with an automated genechip array for a fast diagnosis having high accuracy, where the sample is processed through lysis, separation, purification, labeling, reacting in the genechip array, taking a photo thereafter and analyzing the photo.

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Номер записи: 17
25-04-2019 дата публикации

Automated systems and methods for preparing biological specimens for examination

Номер: US20190120736A1
Автор: Brian McKeen, Daniel Lapen, David Zahniser, Dennis Poole, Eric D. YEATON, Mark Licari
Принадлежит: Roche Diagnostics Hematology Inc

The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.

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Номер записи: 18
02-05-2019 дата публикации

PERFORMING ANTIMICROBIAL SUSCEPTIBILITY TESTING AND RELATED SYSTEMS AND METHODS

Номер: US20190128910A1
Автор: Hayes Ronan, Otten Paul, Passernig Anna, Purmort Nathan, Richardson Bruce, Stern Eric, Tragni Randy, Tsupryk Andriy, Vacic Aleksandar
Принадлежит:

In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells. 121-. (canceled)22. A method for performing multi-assay rapid antimicrobial susceptibility testing sequences , the method comprising:inoculating a sample comprising a microorganism derived from a clinical sample into a plurality of wells of a test panel, at least a portion of the plurality of wells containing one or more antimicrobials of a plurality of antimicrobials for inoculation of the sample;loading the test panel into an automated rapid antimicrobial susceptibility testing system for performing a multi-assay testing sequence; and move the loaded test panel to an incubation assembly comprising a nest assembly adapted to: i) house at least one test panel, and ii) facilitate incubation of one or more test panels in order to undergo the multi-assay testing sequence the incubation assembly comprising: an agitation system configured to generate a repeated motion of the nest assembly;', 'incubate and agitate the inoculated sample in the incubation assembly;', 'at least once, periodically measure an amount of sample growth in a ...

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Номер записи: 19
10-06-2021 дата публикации

METHODS AND APPARATUS TO MITIGATE BUBBLE FORMATION IN A LIQUID

Номер: US20210170414A1
Автор: Davidson Cheryl L., II Robert Paul, Luoma, Ochranek Brian L., Weston Bradley C.
Принадлежит:

Methods and apparatus to mitigate bubble formation in a liquid are disclosed. An example apparatus disclosed herein includes a bottom wall, a first baffle cantilevered from the bottom wall, and a second baffle cantilevered from the bottom wall. The first baffle is spaced apart from the second baffle, and the first baffle and the second baffle are positioned radially relative to an axis of rotation of the apparatus. 1. A reagent container comprising:a first sidewall;a second sidewall opposite the first sidewall;a bottom wall coupled to the first sidewall and the second sidewall;a first baffle extending from the bottom wall, the first baffle spaced apart from the first sidewall and the second sidewall such that a liquid reagent in the reagent container can flow between the first baffle and the first and second sidewalls;a second baffle extending from the bottom wall, the second baffle spaced apart from the first sidewall and the second sidewall such that the liquid reagent in the reagent container can flow between the second baffle and the first and second sidewalls; anda top wall coupled to the first sidewall and the second sidewall opposite the bottom wall, an opening defined in the top wall, the opening structured to receive a pipette for extracting the liquid reagent from the reagent container, the opening in the top wall disposed along an axis that extends between first and second baffles.2. The reagent container of claim 1 , wherein the bottom wall has a circular recess aligned with the opening.3. The reagent container of claim 1 , wherein the top wall includes an upward extending throat claim 1 , the opening defined through the throat.4. The reagent container of claim 2 , further including a cap removably couplable to the throat.5. The reagent container of claim 1 , further including a base couplable to a rotatable carousel of a diagnostic analyzer claim 1 , the bottom wall coupled to the base.6. The reagent container of claim 1 , further including the liquid ...

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Номер записи: 20
07-06-2018 дата публикации

MULTI-TEST ASSAY SYSTEMS AND METHODS OF USING THE SAME

Номер: US20180156734A1
Автор: Blanch Ian, Dietze William T., Johnston Kyle S., Ramsey Tim F., White Wallace C.
Принадлежит:

Embodiments disclosed herein are directed to multi-test assay systems for analyzing biological material and methods of using such multi-test assay systems. For example, the multi-test assay system can detect or identify one or more biological markers representative of or corresponding to an illness or disease. 1. A multi-test assay system for assaying a biological sample in an assay cartridge , the multi-test assay system comprising:one or more cartridge-locator elements sized and configured to position and orient the assay cartridge;one or more actuators positioned and configured to interface with and operate one or more corresponding assay controls on the assay cartridge;one or more light sources configured to illuminate one or more selected locations relative to the one or more cartridge-locator elements; and an image detector; and', 'a spectrograph configured to transform target light received from at least one of the one or more selected locations to dispersed-target light received at the image detector., 'a light analyzer assembly including2. The multi-test assay system of claim 1 , further comprising a controller operably coupled to the image detector claim 1 , the controller being configured to determine one or more wavelengths of a signal light within the target light claim 1 , the signal light being generated from the biological sample producing one or more selected wavelengths of light.3. The multi-test assay system of claim 2 , wherein the signal light is generated from a reaction in the biological sample.4. The multi-test assay system of claim 2 , wherein the controller is configured to correlate the determined one or more wavelengths of the signal light to at least one diagnosis.5. The multi-test assay system of claim 1 , further comprising:a base; anda tray connected to the base and movable relative thereto, the tray includes the one or more cartridge-locator elements and is sized and configured to accept the assay cartridge.6. The multi-test assay ...

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Номер записи: 21
07-06-2018 дата публикации

DEVICE FOR SOLID-PHASE MICROEXTRACTION

Номер: US20180156836A1
Автор: Bremer Ralf, Rose Bernhard
Принадлежит:

Device for solid-phase microextraction and analysis of substances to be analyzed, in particular in a gas chromatograph, with at least one collector, which is made of sorbent and/or adsorbent material and is placed on a rod-like support, and with at least one sample container, which is sealed with a pierceable partition wall and into which the collector is introduced piercing the partition wall for a sampling time, wherein the sealing of the sample container is assembled from the pierceable partition wall and a clamping ring, which can be mounted on the sample container and presses the partition wall together with a sealing element onto an upper rim of the sample container, and which comprises a socket in which a fitting of a transport adapter which is attached to a handling end of the rod-like support can be anchored detachably and with sealing surface pressure after the collector is inserted into the sample container following piercing the partition wall. 111-. (canceled)12. A device for solid-phase microextraction and analysis of substances to be analyzed with at least one collector , wherein the collector comprises a rod-like support having a diameter in the range of 1 mm to 6 mm , and a tube of sorbent and/or adsorbent material which is pushed onto the rod-like support , the tube having a wall thickness in the range of 0.05 mm to 2 mm; wherein the device further comprises at least one sample container , which is sealed with a pierceable partition wall and into which the collector is introduced by piercing the partition wall for a sampling time , the sealing by means of the partition wall is designed to be leak-tight to fluids , wherein the seal of the sample container is assembled from the pierceable partition wall and a clamping ring , which can be mounted on the sample container and presses the partition wall together with an insertable sealing element onto an upper rim of the sample container , and wherein the seal comprises a socket secured between the ...

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Номер записи: 22
24-06-2021 дата публикации

Container rotation device

Номер: US20210187454A1
Автор: Glenn Price, Natasha PANATTONI
Принадлежит: Bio Rad Laboratories Inc

Described herein are devices and methods for rotating a container (e.g., a capped tube containing a sample). The disclosure provides devices and methods of rotating a container using one motor, resulting in a less complex device. The device moves and rotates a container rotating member which in turn is used to rotate a container. The devices can be used in automated analytical instruments (e.g., automated blood analyzers) that automatically transport and detect the identity of sample containers. The devices can also be used in instruments that automatically spin sample containers to mix or homogenize the sample.

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Номер записи: 23
23-05-2019 дата публикации

METHOD AND DEVICE FOR TUNING OPTICAL MEASUREMENTS ON CONTINUOUSLY MIXED REACTORS

Номер: US20190154567A1
Автор: FRANK David, Herzog Konrad
Принадлежит:

A method for tuning optical measurements on continuously mixed reactors, wherein a content of the reactor has at least one optically detectable measured variable, which is carried out by at least one optical measuring arrangement, wherein at least one optical measurement is tuned to a form, distribution, or movement state of at least one phase of the reactor content, wherein mixing the reactor content causes local changes in the permittivity within the reactor, which is detected at at least one location having a known distance from the at least one optical measuring arrangement to be tuned based on a permittivity signal, and wherein the detected permittivity signal of at least one location having a known distance from the at least one optical measuring arrangement to be tuned is used to tune at least one optical measurement to the form, distribution, or movement state of the reactor content. 181. A method for tuning () optical measurements on continuously mixed reactors () ,{'b': 2', '1, 'wherein a reactor content () of the reactor () has at least one optically detectable measured variable,'}{'b': '3', 'wherein at least one optical measuring arrangement () can carry out optical measurements of at least one of the optically detectable measured variables,'}{'b': 2', '2', '2, 'wherein at least one optical measurement is to be tuned to a form, distribution, or movement state of at least one phase (A, B) of the reactor content (),'}{'b': 2', '1, 'wherein mixing the reactor content () causes local changes in the permittivity within the reactor (),'}characterized in that,{'b': 3', '6, 'a local permittivity is detected at at least one location having a known distance from the at least one optical measuring arrangement () to be tuned based on a permittivity signal (), and'}{'b': 6', '3', '2, 'the detected permittivity signal () of at least one location having a known distance from the at least one optical measuring arrangement () to be tuned is used to tune at least one ...

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Номер записи: 24
08-07-2021 дата публикации

AUTOMATED ASSAY PROCESSING METHODS AND SYSTEMS

Номер: US20210208169A1
Автор: CHEN Guang, Liu Qiang, Sang Liyun, Wee Brian
Принадлежит:

Embodiments of automated assay processing systems and methods are disclosed. In an example, an assay automation system includes an assay processing tube, a magnet, and a controller. The assay processing tube has a right arm and a left arm, the right arm having an opening for receiving reagent transferred from a reagent tube being held in one of the tube-holding arms of the reagent tube holder, the assay processing tube being driven to rotate. The magnet is driven to move vertically. The controller is configured to control coordinated movements of the assay processing tube and the magnet to perform an assay processing sequence. 1. A system for assay automation , comprising:an assay processing tube assembly of a pre-configured shape, the assay processing tube assembly including one or more assay processing tubes, each assay processing tube including a reaction chamber for receiving a reagent, the assay processing tube assembly being driven to rotate;a magnet assembly including one or more magnets secured on a magnet holder, a number of magnets corresponding to a number of assay processing tubes, the magnet assembly being driven to move vertically; anda controller configured to control coordinated movements of the assay processing tube assembly and the magnet assembly to perform an assay processing sequence.2. The system of claim 1 , further comprising a reagent cartridge assembly configured to have one or more fluidic channels claim 1 , a number of fluidic channels corresponding to a number of assay processing tubes of the assay processing tube assembly claim 1 , and one or more sets of reagent reservoirs connected to the fluidic channels.3. The system of claim 2 , wherein the reagent reservoirs are syringes or blister packs.4. The system of claim 1 , further comprising one or more sets of dispensers above the assay processing tubes claim 1 , each set of dispensers having a same number of dispensers as a number of assay processing tubes in each set of assay processing ...

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Номер записи: 25
13-06-2019 дата публикации

IN-VITRO DIAGNOSTIC ANALYSIS METHOD AND SYSTEM

Номер: US20190178902A1
Автор: Guzek Christian, Meyer Thomas, Schacher Gottlieb, Sigrist Rolf
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively. 1. A system for in-vitro diagnostic analysis , the system comprising:a vessel processing area comprising at least one static vessel holder and at least one movable vessel workstation comprising a vessel gripper;at least one pipette head comprising at least two pipetting devices movable in a space above the vessel processing area; and the addition of a first reagent type to a first test liquid during a first cycle time,', 'the addition of a second reagent type to the first test liquid during a second cycle time,', 'the addition of the first reagent type to the first test liquid comprising parallel addition of a second reagent type to a second test liquid during the first cycle time, and', 'the addition of the second reagent type to the first test liquid comprising parallel addition of the first reagent type to a third test liquid during a second cycle time, respectively., 'a controller programmed to control the at least one vessel workstation, the at least one pipette head and the at least two pipetting devices for executing a number of scheduled process operations comprising2. The system of claim 1 , wherein a vessel is a cuvette comprising a body claim 1 , an upper opening claim 1 , and at least one lip projecting outwards from the cuvette body in proximity of the upper opening to be gripped by the vessel gripper.3. The system of claim 1 , further comprising claim 1 ,a reagent holding unit for ...

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Номер записи: 26
06-07-2017 дата публикации

Process and machine for automated agglutination assays with image automated evaluation

Номер: US20170192002A1
Автор: Jennifer Roth, John Griffiths, Peter Van Praet
Принадлежит: Gold Standard Diagnostics

The machine is configured to perform an automated rapid plasma reagent (RPR) agglutination test or other agglutination test. The machine includes a sample rack with multiple sample locations thereon and a reagent rack for storing of reagent. A shaker assembly supports at least one microtiter plate or other well supporting structure thereon with a plurality of wells in the plate. An automated pipette accesses samples and reagent and deposits them within wells of the microtiter plate. The shaker assembly shakes multiple samples within the wells of the microtiter plate. Finally, a camera photographs the wells of the plate, preferably from above with a light source below and the plate at least partially transparent. The image is then analyzed in an automated fashion to determine whether a ring of contrast material has remained smooth indicative of a non-reactive sample or has agglutinated/clumped together indicative of a reactive sample.

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Номер записи: 27
06-07-2017 дата публикации

SYSTEMS AND METHODS FOR AUTOMATED, CUSTOMIZABLE SAMPLE PREPARATION FOR DETECTION OF METABOLITES AND LIPIDS

Номер: US20170192029A1
Автор: Bitenc Marko, Castillo Paola Hurtado, Girón Ana María Jiménez, Gomez Antonio Jesus Adsuar, Gómez Patricia Rodríguez, Hense Christian, Kruusmaa Kristi, Martinez Rosa Argamasilla, Martinez-Barea Juan, Rossell Andreu Fabregat
Принадлежит:

Described herein are automated and customizable sample preparation and analysis systems for detection and quantification of biomarkers (e.g., metabolites and/or lipids) in biological samples (e.g., blood, serum, or plasma) in a clinical setting. The automated systems are controlled by scripts that integrate communication between the components of the sample preparation system. Also described herein are mass spectrometry-based analytical methods featuring efficient system calibration and sample analysis that provide for accurate quantification of a set of markers in biological samples. The methods are capable of automatic high sample throughput in a clinical setting for detection and quantification using a mass spectrometry system and high performance liquid chromatography column. 112-. (canceled)13. A method for automated sample handling for extraction , detection and quantification of at least one metabolite biomarker in at least one biological sample , the method comprising:thawing the at least one biological sample on a cooler block shaped and sized to hold the at least one biological sample; (i) the at least one biological sample into at least one plate,', '(ii) at least one blank sample into the at least one plate, and', '(iii) at least one quality control sample into the at least one plate;, 'pipettingshaking the at least one biological sample;incubating the at least one biological sample on the cooler block;centrifuging the at least one biological sample a first time;removing a first supernatant from the at least one centrifuged biological sample to at least one first analysis plate;applying nitrogen flow to the first supernatant of the at least one biological sample;resuspending the at least one centrifuged biological sample;centrifuging the at least one biological sample a second time;removing a second supernatant from the at least one centrifuged biological sample to at least one second analysis plate;placing the at least one second analysis plate in a ...

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Номер записи: 28
22-07-2021 дата публикации

HIGH THROUGHPUT SYSTEM FOR PERFORMING ASSAYS USING ELECTROCHEMILUMINESCENCE INCLUDING A CONSUMABLE SHAKING APPARATUS

Номер: US20210223272A1
Автор: Edens Carl Theodore
Принадлежит:

The present invention relates to a system for performing assays on a solid phase to measure the level of analyte in a sample. Such a system may perform immunoassays using electrochemiluminescence (ECL) including a counterbalanced orbital shaking apparatus for assay consumables. The counter-balanced orbital shaking apparatus also incubates the assay consumables, and has a cooling system to maintain a preset temperature within the shaking apparatus. 1. An ECL immunoassay system comprising a housing that encloses a pipette dispenser , a plurality of multi-well plates adapted to hold ECL complexes attached to electrodes contained in the plurality of multi-well plates , which are sized and dimensioned to be stored in an incubator , a blower , an ECL reader and at least one cooler ,wherein the at least one cooler is located proximate to a back surface of the housing,wherein the incubator comprises at least one airflow channel disposed therewithin and the blower is positioned to pull air from the housing through the at least one airflow channel, and said air is ducted to an inlet of the at least one cooler to cool said air.2. The ECL immunoassay system of claim 1 , wherein said air is blown by the at least one cooler through a plenum into the housing.3. The ECL immunoassay system of claim 1 , wherein a temperature sensor connected to the at least at least one cooler is positioned proximate to an entrance of the at least one airflow channel.4. The ECL immunoassay system of claim 3 , wherein said temperature sensor is a thermostat of the at least one cooler.5. The ECL immunoassay system of claim 3 , wherein said temperature sensor comprises a thermistor.6. The ECL immunoassay system of claim 1 , wherein said air is ducted to an inlet of the at least one cooler through a hood positioned above the blower.7. The ECL immunoassay system of claim 6 , wherein said air is further ducted to an inlet of the at least one cooler through a chimney connected to said a hood claim 6 ,8. The ...

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Номер записи: 29
22-07-2021 дата публикации

BLOOD SAMPLE ANALYZER, BLOOD SAMPLE ANALYSIS METHOD AND COMPUTER STORAGE MEDIUM

Номер: US20210223276A1
Автор: Hu Lijian, XIE Zixian
Принадлежит:

Disclosed is a blood sample analyzer, including: a sample conveying device for conveying a sample rack loaded with a sample container; a first agitating device having a sample stirring component for stirring a blood sample in the sample container and being capable of driving the sample stirring component to uniformly agitate the blood sample in the sample container; a second agitating device capable of picking up the sample rack or a second sample container on the sample rack, and driving the second sample container containing a common-volume blood sample on a second agitating position to uniformly agitate the blood sample; and a controller configured to communicate with the sample conveying device, the first agitating device and the second agitating device, and control the sample conveying device, the first agitating device and the second agitating device. In addition, the present application further discloses a blood sample agitating device, a blood sample analysis method, and a computer storage medium. 149-. (canceled)50. A blood sample analyzer , comprising:a sample conveying device for conveying a sample rack loaded with a first and/or second sample container;a first agitating device having a sample stirring component for stirring a blood sample in the first sample container, the first agitating device being capable of driving the sample stirring component to agitate a small-volume blood sample contained in the first sample container on the sample rack at a first agitating position;a second agitating device capable of picking up the sample rack or the second sample container on the sample rack, and driving the second sample container containing a common-volume blood sample to a second agitating position to agitate the common-volume blood sample; anda controller configured to communicate with the sample conveying device, the first agitating device and the second agitating device, and control actions of the sample conveying device, the first agitating device and ...

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Номер записи: 30
21-07-2016 дата публикации

Automated systems and methods for preparing biological specimens for examination

Номер: US20160209302A1
Автор: Brian J. Mckeen, Daniel Lapen, David Zahniser, Dennis Poole, Eric D. YEATON, Mark Licari
Принадлежит: Roche Diagnostics Hematology Inc

The systems and methods disclosed herein permit automated preparation of biological specimens for examination. The disclosed systems and methods provide fast, efficient, and highly uniform specimen processing using minimal quantities of fluids. The methods include at least a fixing phase for fixing a biological specimen to a substrate such as a microscope slide, a staining phase for staining the specimen, and a rinsing phase for rinsing the specimen. One or more of the fixing, staining, and rinsing phases include one or more agitation cycles for distributing reagents evenly and uniformly across the specimen. The systems can be implemented as a standalone device or as a component in a larger system for preparing and examining biological specimens.

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Номер записи: 31
05-08-2021 дата публикации

BLOOD SAMPLE ANALYZER AND BLOOD SAMPLE AGITATING METHOD

Номер: US20210239725A1
Автор: Hu Lijian, LIU Yuanxing, XIE Zixian
Принадлежит:

Disclosed in the present invention is a blood sample analyzer, including a sample conveying device, a first agitating device, a second agitating device and a controller, etc. When the first agitating device drives a sample container placed in a sample container accommodating hole to agitate a blood sample, a bottom of the sample container is kept lower than an opening of the sample container. In addition, the present invention further discloses a blood sample agitating device, a blood sample analysis method, a blood sample agitating method, and a computer storage medium. 167-. (canceled)68. A blood sample analyzer , comprising:a sample conveying device for conveying a sample rack loaded with a first sample container and/or a second sample container;a first agitating device having an accommodating hole for placing the first sample container, the first agitating device being capable of driving the first sample container containing a small-volume blood sample and placed in the accommodating hole to agitate the small-volume blood sample;a second agitating device capable of picking up the sample rack or the second sample container on the sample rack, and driving the second sample container containing a common-volume blood sample to agitate the common-volume blood sample; anda controller configured to communicate with the sample conveying device, the first agitating device and the second agitating device, and control the sample conveying device, the first agitating device and the second agitating device;wherein when the first agitating device drives the first sample container placed in the accommodating hole to agitate the small-volume blood sample, a bottom of the first sample container is kept lower than an opening of the first sample container.69. The blood sample analyzer according to claim 68 , further comprising:a carrying device capable of carrying the first sample container on the sample rack, which is conveyed by the sample conveying device to a predetermined ...

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Номер записи: 32
09-08-2018 дата публикации

SPECIMEN TREATMENT CHIP, SPECIMEN TREATMENT APPARATUS, AND SPECIMEN TREATMENT METHOD

Номер: US20180221881A1
Автор: KAWAMOTO Yasuko, Nakano Tsuyoshi, TAGAWA Ayato, TOBIMATSU Hiroaki, YAMAWAKI Koya
Принадлежит:

The present specimen treatment chip includes: a first flow channel for forming a droplet containing a mixed liquid of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which a primer for binding to the nucleic acid is added, in a dispersion medium; a second flow channel for amplifying the nucleic acid in the droplet; and a third flow channel for mixing the droplet containing the carrier with the primer having bound to an amplification product of the nucleic acid, and a reagent for breaking down the droplet, to break down the droplet. 1. A specimen treatment chip configured to be installed in a specimen treatment apparatus to treat a nucleic acid in a specimen , the specimen treatment chip comprising:a fluid module provided with a breaking-down flow channel for mixing a droplet containing a carrier binding to an amplification product of the nucleic acid, amplified in the droplet, and a reagent for breaking down the droplet, to break down the droplet; anda substrate that is provided on its first surface with the fluid module,whereinthe substrate is provided with through holes each of which connects to a connection portion of the fluid module on a first surface side so that a liquid is injected or discharged through each of the through holes.2. The specimen treatment chip according to claim 1 , wherein the breaking-down flow channel includes a connection portion for allowing the droplet to flow therethrough claim 1 , and a connection portion for allowing a reagent for breaking down the droplet to flow therethrough.3. The specimen treatment chip according to claim 1 , further comprising a marking flow channel for causing the amplification product on the carrier extracted from the droplet by breaking down and a marking substance for detecting the amplification product to bind to each other.4. The specimen treatment chip according to claim 3 , wherein the breaking-down flow channel and the marking flow channel are connected so ...

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Номер записи: 33
09-08-2018 дата публикации

Devices, systems and methods for sample preparation

Номер: US20180224472A1
Автор: Alexander Loo, Elizabeth A. Holmes
Принадлежит: Theranos IP Co LLC

Devices, systems and methods including a sonicator for sample preparation are provided. A sonicator may be used to mix, resuspend, aerosolize, disperse, disintegrate, or de-gas a solution. A sonicator may be used to disrupt a cell, such as a pathogen cell in a sample. Sample preparation may include exposing pathogen-identifying material by sonication to detect, identify, or measure pathogens. A sonicator may transfer ultrasonic energy to the sample solution by contacting its tip to an exterior wall of a vessel containing the sample. Multipurpose devices including a sonicator also include further components for additional actions and assays. Devices, and systems comprising such devices, may communicate with a laboratory or other devices in a system for sample assay and analysis. Methods utilizing such devices and systems are provided. The improved sample preparation devices, systems and methods are useful for analyzing samples, e.g. for diagnosing patients suffering from infection by pathogens.

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Номер записи: 34
23-08-2018 дата публикации

IN-VITRO DIAGNOSTIC ANALYSIS METHOD AND SYSTEM

Номер: US20180238919A1
Автор: Guzek Christian, Meyer Thomas, Schacher Gottlieb, Sigrist Rolf
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A method and system for automatic in-vitro diagnostic analysis are described. The method includes adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid includes parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid includes parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively. 1. An automatic in-vitro diagnostic analysis method comprising:adding a first reagent type to a first test liquid, wherein the addition of the first reagent type comprises dispensing the first reagent type into a vessel held by a static vessel holder; andadding a second reagent type to a second test liquid, wherein the addition of the first reagent type to the first test liquid comprises parallel addition of the second reagent type to the second test liquid and wherein the addition of the second reagent type comprises dispensing the second reagent type into a vessel being held by a gripper of a movable vessel workstation.2. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the first reagent type is an incubation reagent.3. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the static vessel holder is an incubation station.4. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the incubation station comprises a temperature regulating unit for maintaining the vessel held by the static vessel holder at an optimal temperature.5. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the static vessel holder is a detection station.6. The automatic in-vitro diagnostic analysis method according to claim 5 , further comprising claim 5 ,shaking the vessel held by the gripper while moving the ...

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Номер записи: 35
06-09-2018 дата публикации

Reagent mixing and conveying device and reagent mixing method

Номер: US20180252707A1
Автор: Gang Wu, HAO Zhang, Jianfei Zheng, Yigang Yang
Принадлежит: Leadway HK Ltd

The present invention provides a reagent mixing device, which comprises a driving device, a transport device and a rotating part, wherein the transport device comprises a conveying mechanism for conveying a reagent kit and a mixing mechanism for mixing a reagent; the conveying mechanism is driven by the driving device to move relative to the mixing mechanism; the rotating part and mixing mechanism are in transmission matching; the conveying mechanism and the mixing mechanism are sleeved with each other to form a bearing structure. The present invention further provides a reagent mixing method. The reagent mixing device is small in size, smart in structure, easy to assemble and low in manufacturing cost. The reagent mixing method provided by the present invention is simple and reliable, high in overall operation reliability, and has very high application values in such analysis and test fields as full-automatic chemiluminescence immunoassay analyzers and biochemical analyzers.

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Номер записи: 36
07-10-2021 дата публикации

PROGRAMMABLE FLUID DISTRIBUTION SYSTEM

Номер: US20210311085A1
Автор: YUKHANANOV Rustam
Принадлежит:

The present inventive concept is an apparatus for programmable fluid delivery and may be used for different detection assays and test that use flow lines for multiple reagents and a tray base with trays coming in multiple sizes. The inventive concept may be used for procedures such as producing biological assay, the procedures using flow lines to carry multiple reagents. The inventive concept has manual and automated settings and is designed to impart either or both vertical up and down motions or horizontal side to side motions on the tray. Valve members are placed parallel to each other instead of all in a line, the valve system controlling and discharging fluid controlled by a set of programmable pinch valve assemblies that pinch or release multiple elastomeric flow conduits. 1. An automated assay apparatus for performing one or more assay procedures using a liquid reagent and a washer liquid , the apparatus comprising:a first vial supporting plate;a first vial adapted to be filled with the liquid reagent, e.g, washer liquid;a first funnel adapted to accept the liquid reagents;a first reaction chamber;a first elastomeric conduit comprising a passageway, a first end of the passageway in communication with the first funnel;a plurality of parallelly aligned valve members; anda second end of the passageway communicatively coupled with the first reaction chamber.2. The automated assay apparatus of claim 1 , wherein the first vial supporting plate is adapted to accept the first vial claim 1 , and further adapted to be inclined to pour the liquid reagent out to the first funnel; and the first elastomeric conduit is adapted to deliver the liquid reagent from the first funnel to the first reaction chamber.3. The automated assay apparatus of claim 2 , wherein the vial supporting plate further comprises at least one first cell member to place the vial claim 2 , a cut portion to install the vial claim 2 , the first cell member adapted to compress against the vial body claim ...

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Номер записи: 37
14-09-2017 дата публикации

CONTINUOUS PROCESS FOR PERFORMING MULTIPLE NUCLEIC ACID AMPLIFICATION ASSAYS

Номер: US20170261431A1
Автор: DAVIS Christopher B., HEINZ Robert E., Knight Byron J., LAIR Gary D., LI Florence, Li Haitao, MACIOSZEK Jerzy A., NGUYEN Thanh N., SCALESE Robert F.
Принадлежит:

A continuous process for performing multiple nucleic acid amplification assays, where at least a portion of a second subset of reaction mixtures are transferred to a heater while a first subset of reaction mixtures are being subjected to conditions for performing a nucleic acid amplification assay. During the process, a plurality of reaction mixtures from the first and second subsets of reaction mixtures are simultaneously subjected to conditions sufficient to perform multiple nucleic acid amplification assays in the reaction mixtures. The presence or absence of a target nucleic acid in the first subset of reaction mixtures is determined while the reaction mixtures are in the heater. 1. A method for determining the presence or absence of target nucleic acid sequences in a plurality of samples , the method comprising the steps of:a) loading a plurality of samples onto a self-contained, stand-alone analyzer, each sample being contained within one of a plurality of receptacles, and each receptacle having an associated label containing machine-readable data;b) reading each associated label with a label reading device, wherein the label reading device is in communication with a computer, and wherein the computer associates each sample with one of at least two nucleic acid amplification assays, the at least two nucleic acid amplification assays including a first nucleic acid amplification assay for amplifying a first target sequence and a second nucleic acid amplification assay for amplifying a second target sequence, and the first and second target sequences being different from each other;c) exposing each sample to a solid support material, the solid support material being capable of immobilizing nucleic acids present in the samples;d) isolating the solid support material within each sample and separating a fluid component of the samples from the solid support material;e) after step d), washing the solid support material with a wash solution, thereby purifying the ...

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Номер записи: 38
14-09-2017 дата публикации

METHOD FOR MIXING A LIQUID IN AN AUTOMATED ANALYZER

Номер: US20170261525A1
Автор: Bernhard Joachim, Verhalen Christian
Принадлежит:

The present invention lies in the field of automated analyzers and relates to a method for mixing liquids in liquid containers. The arrangement for automated mixing comprises a shaking device and a gripper which is connected by way of a flexible connecting element to a transfer arm and which serves for receiving a liquid container. The coupling of gripper and shaking device is realized by way of an eccentrically movable coupling pin and a coupling hole provided for this purpose. 1. A method for mixing a liquid in a liquid container , the method comprising the steps of:(a) receiving the liquid container by way of a gripper which is fastened by way of a flexible connecting element to an automatically movable transfer arm, wherein the gripper has a coupling hole; then(b) displacing the gripper with the liquid container to a shaking device having a coupling pin which is movable about a vertical axis of rotation; then(c) inserting the coupling pin of the shaking device into the coupling hole of the gripper in a direction coaxial with the vertical axis of rotation of the coupling pin; and then(d) moving the coupling pin;wherein:after insertion of the coupling pin of the shaking device into the coupling hole provided on the gripper in step (c), the gripper or the shaking device is firstly displaced perpendicular to the vertical axis of rotation of the movable coupling pin before the coupling pin is set in motion.2. The method as claimed in claim 1 , wherein the gripper or the shaking device is displaced perpendicularly to the vertical axis of rotation of the movable coupling pin until an inner wall of the coupling hole exerts a transverse force on the coupling pin claim 1 , before the coupling pin is set in motion.3. The method as claimed in claim 1 , wherein the gripper is displaced perpendicularly to the vertical axis of rotation of the movable coupling pin by horizontal displacement of the transfer arm.4. The method as claimed in claim 1 , wherein the liquid is from a ...

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Номер записи: 39
04-12-2014 дата публикации

Driving apparatus for analyzing apparatus

Номер: US20140354193A1
Автор: Kenji Nakanishi, Yoshiyuki Fujii
Принадлежит: Panasonic Healthcare Co Ltd

Disclosed is an analyzing apparatus including a first drive part ( 71 ) for rotating a turntable ( 101 ) on which an analyzing device is set, a second drive part ( 72 ) selectively engaged with the first drive part ( 71 ) to reciprocate the analyzing device, and a third drive part ( 73 ) for relatively moving the first drive part ( 71 ) and the second drive part ( 72 ) a position where the first and second drive parts are engaged with each other and a position where the first and second drive parts are not engaged with each other. Thus in the mixing and agitation of a small amount of fluid, necessary acceleration can be obtained even in a short time.

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Номер записи: 40
28-10-2021 дата публикации

Pretreatment apparatus and pretreatment method

Номер: US20210333299A1
Автор: Hiroyasu Sumida, Seiichiro Tabata, Takeshi Yamamoto, Yoshihiko KITAWAKI
Принадлежит: Sysmex Corp

A pretreatment apparatus (100) for performing pretreatment of a sample is provided with a holder (610) for holding a container (10) containing a sample, a centrifugal separation device (600) for rotating the container (10) held by the holder (610) to perform a centrifugal separation, a temperature adjustment device (420) for adjusting the temperature of the sample in the container (10) in the holder (610), an input device (320) for receiving from a user a designated temperature that is adjusted by the temperature adjustment device (420), a controller (300) for controlling the temperature adjustment device (420) in accordance with the designated temperature received via the input device (320).

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Номер записи: 41
08-10-2015 дата публикации

ANALYSIS DEVICE FOR IN VITRO DIAGNOSTICS

Номер: US20150285829A1
Автор: Rousseau Alain
Принадлежит: ALAIN ROUSSEAU- TECHNIQUES & INNOVATIONS (ARTEION)

This analysis device includes at least one rack intended to receive a plurality of containers containing samples of biological liquid to be analyzed, a loading module arranged to move the at least one rack between a loading position and a first intermediate position, a shaking module arranged to move the at least one rack between the first intermediate position and a second intermediate position and to shake the at least one rack, an unloading module arranged to move the at least one rack between the second intermediate position and an unloading position, where the loading and unloading modules are arranged to move the at least one rack respectively along a first and a second movement directions transverse to the plane of the at least one rack, and where the shaking module is arranged such that the at least one rack extends substantially along a same orientation in the first and second intermediate positions. 1. An analysis device for in vitro diagnosis , comprising:at least one rack intended to receive a plurality of containers equipped with sealing elements and containing samples of biological liquid to be analyzed,a loading module arranged to move the at least one rack between a loading position and a first intermediate position along a first movement direction transverse to the plane of the at least one rack,a shaking module arranged to move the at least one rack between the first intermediate position and a second intermediate position and to shake the at least one rack, the shaking module being arranged such that the at least one rack extends substantially along a same orientation in the first and second intermediate positions,an unloading module arranged to move the at least one rack between the second intermediate position and an unloading position along a second movement direction transverse to the plane of the at least one rack, anda sampling module arranged to take samples of biological liquid in the containers received in the at least one rack,the ...

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Номер записи: 42
05-09-2019 дата публикации

DEVICE AND METHOD FOR BLOOD ANALYSIS BY IMAGE PROCESSING

Номер: US20190272637A1
Автор: DA SILVA FERRAZ Ana Patricia, Mendes Da Costa Carvalho Vitor Hugo
Принадлежит:

The present application describes a new device and method of use thereof, which allows identifying certain antigens and antibodies present in the blood. The device of the present invention is a closed device consisting of two parts, wherein the upper part has a chamber surrounded by LEDs illuminating the analysis plate, which is supported by the rotating platform. In turn, the rotating platform is connected to a motor that will promote the rotation thereof for mixing reagents with blood. After a period of time, the camera will capture and send the resulting image to a computer program that will analyze the sample, using image processing techniques. 1. A method for detecting immunological agglutination of blood samples using a device comprising:a) placing each of the reagents in the respective containers of an analysis plate, and then the patient's blood to be analyzed, both in their respective proportions;b) placing the analysis plate in the device, fixing the plate to the rotating platform;c) closing the device by joining the upper part of the device with the lower part and starting the device; i. moving rotationally the platform, via the motor for a time between 60 and 130 seconds, during which the reaction takes place;', 'ii. stopping the motor and turning on the LEDs; and', 'iii. after 2 minutes, capturing the image with the camera;, 'd) activating the camera, LEDs and motor, according to the following stepse) turning off the LEDs;f) sending the camera's image to the mobile device, which in turn stores this image;g) treating the image by image processing techniques; andh) classifying the occurrence or non-occurrence of agglutination via the classification algorithm according to the standard deviation value obtained for each of the test containers.2. The method for detecting immunological agglutination of blood samples according to claim 1 , wherein the blood to reagent ratio consists of a drop of whole blood having one-forth of the reagent drop size.3. The ...

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Номер записи: 43
11-10-2018 дата публикации

AUTOMATED REAGENT MANAGER OF A DIAGNOSTIC ANALYZER SYSTEM

Номер: US20180290140A1
Автор: Donohue Joseph P., Rai Surya Pratap
Принадлежит:

A reagent manager for a diagnostic analyzer system includes a reagent manager housing, a high-speed reagent bottle spinning device, a processor, and a memory. The reagent manager housing is for housing reagent bottles. The high-speed reagent bottle spinning device is disposed within the reagent manager housing for spinning at least one of the reagent bottles. The processor is in electronic communication with the high-speed reagent bottle spinning device. The memory is in electronic communication with the processor. The memory includes programming code for execution by the processor. The programming code is configured to spin the high-speed reagent bottle spinning device to spin the at least one reagent bottle to remove microparticles from a bottom surface of a septum of the at least one reagent bottle. 1. A reagent manager for a diagnostic analyzer system comprising:a reagent manager housing containing a reagent bottle having microparticles accumulated to an inner surface of a septum, the inner surface configured to allow a pipetting device of the diagnostic analyzer system to access within the reagent bottle, and having liquid disposed within the reagent bottle;a first spinning device, comprising a first gear, disposed within the reagent manager housing;a second spinning device, comprising a second gear, disposed within the reagent manager housing;a processor in electronic communication with the first and second spinning devices; anda memory in electronic communication with the processor, wherein the memory comprises programming code for execution by the processor, and the programming code is configured to control the first spinning device so that the first gear spins the reagent bottle, around an axis through the reagent bottle, at a first speed in a plurality of cycles thereby causing a turbulent flow of the liquid within the reagent bottle causing the liquid to contact and remove the microparticles from the inner surface of the septum of the reagent bottle, and ...

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Номер записи: 44
20-10-2016 дата публикации

SHAKING DEVICE FOR FULLY-AUTOMATIC INSTANT CHECK METER

Номер: US20160303528A1
Автор: Chen Xiaodong, HONG Longbin, Hu Rui, SHEN Guojin, Xu Wenjie, ZHOU Songbing, ZHOU Xuyi
Принадлежит:

A shaking device for a fully-automatic instant check meter, which is used for shaking blood in a test tube uniformly. The shaking device comprises a frame body, a barcode printer, a first bracket, a second bracket, a rotating mechanism, a vacuum blood vessel shaking mechanism and a peripheral blood vessel shaking mechanism, wherein a first sliding rail, a first motor and a second motor are provided on the frame body; the rotating mechanism is connected to the first sliding rail in a sliding manner via a first sliding block and is connected to the first motor via a first synchronous belt; the vacuum blood vessel shaking mechanism is connected to the first sliding rail in a sliding manner via a second sliding rail and is connected to a second motor via a second synchronous belt; the peripheral vessel shaking mechanism is arranged below the vacuum blood vessel shaking mechanism; and the barcode printer is arranged at one side of the frame body. The shaking device has a simple structure and a good shaking effect, and is safe and reliable. 1. A shaking device for a fully-automatic instant check meter is used for shaking blood in a test tube uniformly , comprising a frame body , a barcode printer , a first bracket , a second bracket , a rotating mechanism , a vacuum blood vessel shaking mechanism and a peripheral blood vessel shaking mechanism , wherein a first sliding rail , a first motor and a second motor are provided on the frame body , the rotating mechanism is connected to the first sliding rail in a sliding manner via a first sliding block and is connected to the first motor via a first synchronous belt , the vacuum blood vessel shaking mechanism is connected to the first sliding rail in a sliding manner via a second sliding rail and is connected to a second motor via a second synchronous belt , the peripheral vessel shaking mechanism is arranged below the vacuum blood vessel shaking mechanism , and the barcode printer is arranged at one side of the frame body.2. ...

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Номер записи: 45
11-10-2018 дата публикации

THERMAL PRINTING ON WALL OF TUBULAR VESSEL

Номер: US20180292427A1
Автор: BUSE DAVID Aaron, MERTEN Matthias, ROSATI ROBERT J., SILBERT Rolf, TAMMER OLEV
Принадлежит: GEN-PROBE INCORPORATED

A sample container of patient sample material includes a sample container barcode containing patient-identifying information. The sample container barcode on the sample container is read, and a tubular reaction vessel is provided to a printer module configured to print a barcode directly onto a surface of the tubular reaction vessel. The printer module prints a barcode on the surface of the reaction vessel by a thermal printing method, and the barcode printed onto the reaction vessel is associated with the sample container barcode. 1. A method for automatically processing patient sample material within a sample processing station , said method comprising:(a) providing, to the sample processing station, a sample container containing a volume of patient sample material, the sample container including a sample container barcode on a surface thereof, the sample container barcode containing patient-identifying information;(b) with a barcode reader, reading the sample container barcode on the sample container in the sample processing station;(c) providing a tubular reaction vessel to a printer module disposed within the sample processing station, the printer module being configured to print a barcode directly onto a surface of the tubular reaction vessel;(d) with the printer module, printing a barcode on the surface of the reaction vessel by a thermal printing method, the barcode printed onto the reaction vessel being associated with the sample container barcode read in step (b); and(e) automatically moving the reaction vessel from the printer module to the sample processing station.2. The method of claim 1 , wherein the sample container barcode and the bar code printed on the reaction vessel are at least partially identical.3. The method of claim 1 , wherein providing the sample container to the sample processing station comprises placing the sample container in an input rack and placing the input rack into a sample processing instrument.4. The method of claim 3 , ...

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Номер записи: 46
25-10-2018 дата публикации

BEAD BEATING TUBE AND METHOD FOR EXTRACTING DEOXYRIBONUCLEIC ACID AND/OR RIBONUCLEIC ACID FROM MICROORGANISMS

Номер: US20180305740A1
Автор: KLAPPROTH Holger, SMIT Nicolaas
Принадлежит: Safeguard Biosystems Holdings Ltd.

The present disclosure provides improved methods for bead beating and a bead beating system useful therefor. The bead beating system comprises a sample tube, beads, and a dry blocking agent, and methods for using the bead beating system to extract nucleic acids from cells containing the nucleic acids. 1. A method for producing a lysate from cells contained in a liquid sample , comprising agitating the liquid sample within a bead beating system in the absence of lysis buffer and in the presence of one or more blocking agents under conditions sufficient to lyse the cells , said bead beating system comprising a bead beating tube and beads.2. The method of claim 1 , wherein the liquid sample contains an endogenous blocking agent.3. The method of claim 2 , wherein the agitating is carried out in the absence additives.4. The method of claim 1 , wherein the one or more blocking agents are exogenous to the liquid sample.5. The method of claim 2 , wherein the beads:a) are adapted to lyse bacteria, yeast, filamentous fungi, spores, plant cells, or animal cells; i. mineral beads, ceramic beads, glass beads, metal beads, or a combination thereof;', 'ii. zirconium beads, zircon beads, zirconia beads, quartz beads, aluminum oxide beads, silicon carbide beads, ceramic beads, silicon dioxide glass beads, stainless steel beads, chrome steel beads, or a combination thereof;, 'b) comprisec) have a diameter ranging from 50 μm to 3 mm; ord) any combination of a)-c).6. The method of claim 1 , further comprising a step of placing the liquid sample within the sample tube prior to agitating the liquid sample.7. The method of claim 1 , wherein the agitating comprises subjecting the bead beating system to an oscillating motion.8. The method of claim 1 , wherein the sample is a biological sample claim 1 , an environmental sample claim 1 , or a food product.9. The method of claim 8 , wherein the sample is a biological sample selected from blood claim 8 , serum claim 8 , saliva claim 8 , urine ...

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Номер записи: 47
03-11-2016 дата публикации

Intelligent Rack

Номер: US20160320421A1
Автор: Habrich Stephan, TRUMP Martin, Zver Martin
Принадлежит:

An automated analyzer system. The system has a rack for automated analyzer systems, the rack comprising at least one position for taking up at least one cartridge; at least one drive for agitating the content of the at least one cartridge; at least one RFID antenna for reading RFID tags of the at least one cartridge and at least one printed circuit board for operating the drive, e.g. a motor. 1. A rack for automated analyzer systems , the rack comprising:at least one position for taking up at least one cartridge;at least one drive for agitating the content of the at least one cartridge;at least one RFID antenna for reading RFID tags of the at least one cartridge; andat least one printed circuit board for operating the drive.2. The rack of claim 1 , wherein the at least one cartridge comprises at least one container or bottle.3. The rack of claim 1 , wherein the at least one cartridge comprises stationary and/or movable container.4. The rack of claim 1 , wherein the at least one drive and the at least one cartridge are connected by means for agitating the at least one cartridge or the at least one container.5. The rack of claim 4 , wherein the at least one container of the at least one cartridge is connected to at least one neighboring container to transfer its agitation.6. The rack of claim 1 , wherein the rack comprises induction coils to transfer power and communicate with the automated system.7. The rack of claim 1 , wherein the rack comprises electrical contacts to transfer power and communicate with the automated system8. The rack of claim 1 , wherein the at least one cartridge comprises barcodes or 2D-codes for identification.9. The rack of claim 1 , wherein the rack comprises a LED indicating the status of the rack to a user.10. The rack of claim 1 , comprising a power source for powering the at least one drive.11. The rack of claim 1 , wherein the at least one drive and the at least one cartridge or the at least one container are connected by gear-wheels for ...

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Номер записи: 48
26-11-2015 дата публикации

ANALYSIS UNIT FOR ANALYSIS DEVICE

Номер: US20150338429A1
Автор: BRUTT Norbert, LERAT Olivier, Rousseau Alain
Принадлежит: IMMUNODIAGNOSTIC SYSTEMS FRANCE

This analysis unit () comprises a rack () suitable for receiving at least a first and a second container (), and an agitating device () suitable for mounting on the rack (), the agitating device () being designed to drive at least the first container () in rotation when the agitating device cooperates with a drive unit of an analysis device. The agitating device () comprises coupling means designed to rotationally couple at least the first and second containers () held on the rack (), the coupling means being configured to drive at least the second container () in rotation when the first container () is driven in rotation by the agitating device. 1. An analysis set for an analysis apparatus , comprising:a carrier intended to be inserted in the analysis apparatus, the carrier being adapted to receive at least one first container of a first type, the carrier comprising:a storage housing intended to receive a plurality of stationary containers of a second type each provided with a neck equipped with a closing device, and 'a stirring device adapted to be mounted on the carrier and intended to cooperate with a driving unit of an analysis apparatus, the stirring device being arranged to rotatably drive at least the first container of the first type when said first container is received on the carrier and when the stirring device cooperates with the driving unit of the analysis apparatus,', 'position holding means arranged to cooperate with the necks of the stationary containers when the stationary containers are received in the storage housing,'}wherein the carrier is adapted to receive at least a second container of the first type, and the stirring device comprises coupling means arranged to rotatably couple at least the first and second containers of the first type when said first and second containers are received on the carrier, the coupling means being shaped to rotatably drive at least the second container when the first container is rotatably driven.2. The analysis ...

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Номер записи: 49
15-11-2018 дата публикации

Device for agitating and collecting biological liquid samples suitable for sorting

Номер: US20180326376A1
Автор: Florent Beauducel, Philippe Benezeth
Принадлежит: Horiba ABX SAS

A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes, a sampling apparatus capable of collecting a biological liquid sample in a tube, and a changer capable of gripping a tube on a rack received in the agitator and moving it to the sampling apparatus. The agitator is capable of agitating at least three racks simultaneously, and the device also comprises a scheduler capable of determining destination data for a tube and destination data for the rack which receives this tube, and of determining for each tube a final location based on the destination data of the tube and the destination data of the racks received in the device, which final location designates a rack, received on the agitator and a position on this rack and can be different from the location of the tube when the rack that received it has been introduced into the device, and arranged to control the changer in order to grip a tube, present it to the sampling apparatus and replace it after sampling at the final location.

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Номер записи: 50
29-11-2018 дата публикации

DEVICE FOR AGITATING AND COLLECTING LIQUID SAMPLES

Номер: US20180340948A1
Автор: ANDLAUER Sylvain, BEAUDUCEL Florent, BENEZETH Philippe
Принадлежит: Horiba ABX SAS

A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes and a sampling apparatus capable of collecting a biological liquid sample in a tube. The device also comprises a scheduler arranged to specify an order of sampling from the tubes independently of the order in which the tubes are positioned in the respective racks and the order in which the racks are inserted into the device. The scheduler is arranged to control the agitator and the sampling apparatus to process the tubes in accordance with the sampling order. 1. A device for agitating and collecting biological liquid samples comprising:an agitator configured to agitate racks of a plurality of tubes;a sampling apparatus capable of collecting a biological liquid sample in a tube; anda scheduler configured to specify a sampling order from the plurality of tubes independently of the order in which the tubes are positioned in the racks and/or the order in which the racks are inserted into the device, wherein the scheduler is further configured to control the agitator and the sampling apparatus to process the tubes according to the sampling order.2. The device as claimed in claim 1 , further comprising a changer capable of gripping a tube on a rack in the agitator and moving it to the sampling apparatus claim 1 , wherein the scheduler controls the order in which the changer grips the tubes according to the sampling order.3. The device as claimed in claim 1 , wherein the agitator is capable of agitating at least three racks simultaneously.4. The device as claimed in claim 1 , wherein the agitator is capable of moving between a first position for inserting the racks into the device and a second position for removing the racks from the device.5. The device as claimed in claim 4 , further comprising a lifting mechanism arranged to move the agitator between the first position and the second position.6. The device as claimed in claim 4 , wherein the changer comprises a ...

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Номер записи: 51
22-12-2016 дата публикации

IN-VITRO DIAGNOSTIC ANALYSIS METHOD AND SYSTEM

Номер: US20160370392A1
Автор: Guzek Christian, Meyer Thomas, Schacher Gottlieb, Sigrist Rolf
Принадлежит:

A method and system for automatic in-vitro diagnostic analysis are described. The method comprises adding a first reagent type and a second reagent type to a first test liquid during a first and second cycle times respectively. The addition of the first reagent type to the first test liquid comprises parallel addition of a second reagent type to a second test liquid during the first cycle time. The addition of the second reagent type to the first test liquid comprises parallel addition of a first reagent type to a third test liquid during the second cycle time, respectively. 1. An automatic in-vitro diagnostic analysis method comprising:adding a first reagent type to a first test liquid, wherein the addition of the first reagent type to the first test liquid comprises parallel addition of a second reagent type to a second test liquid and wherein the first reagent type is an incubation reagent and the second reagent type is a time-trigger reagent; andadding the second reagent type to the first test liquid, wherein the addition of the second reagent type to the first test liquid comprises parallel addition of the first reagent type to a third test liquid.2. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the addition of the first reagent type comprises dispensing the first reagent type into a vessel held by a static vessel holder.3. The automatic in-vitro diagnostic analysis method according to claim 1 , wherein the addition of the second reagent type comprises dispensing the second reagent type into a vessel being held by a gripper of a movable vessel workstation4. An automatic in-vitro diagnostic analysis method comprising:adding a first reagent type to a first test liquid, wherein the addition of the first reagent type to the first test liquid comprises parallel addition of a second reagent type to a second test liquid and wherein the first reagent type is an incubation reagent and the second reagent type is a time-trigger reagent; ...

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Номер записи: 52
24-12-2002 дата публикации

Method of handling reagents in a random access protocol

Номер: US6498037B1
Автор: Glen Carey, Scott C. Lewis
Принадлежит: Bayer Corp

An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation system for separating bound from unbound tracer or labeled reagent, a detection system and date collection/processing system. All of the subunits of the machine are controlled by a central processing unit to coordinate the activity of all of the subunits of the analyzer. The analyzer is specifically suited for performing heterogeneous binding assay protocols, particularly immunoassays.

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Номер записи: 53
16-04-2003 дата публикации

Chemical analysis using array hybridization

Номер: EP1302244A1
Автор: Gary B. Gordon
Принадлежит: AGILENT TECHNOLOGIES INC

Array hybridization can be facilitated by agitating a reaction cell (30) subject to centrifugal force greater than 1G. A two-dimensional hybridization array (40) is preferably oriented generally orthogonal to the centrifugal force (45). Agitation involves titling the array back and forth about an axis (41), preferably parallel to a centrifuge axis. The centrifugal force serves, in a sense, as supergravity helping to overcome non-specific binding forces (viscous forces and other forces at the liquid-solid boundary) that limit the rate of liquid flow. Thus, the agitation rate and the related replenishment rate can be increased. The agitation causes the sample liquid (39) to wash back and forth across the array, which remains protected by a thin liquid film. The resulting "tidal" motion, results in thorough mixing of the sample liquid. In addition, since only a thin film is required over much of the array, typically costly sample volume can be reduced. Thus, faster hybridization with lower sample volumes can be achieved.

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Номер записи: 54
20-04-2006 дата публикации

Chemical reaction apparatus

Номер: US20060083667A1
Автор: Hideyuki Noda, Yoshinobu Kohara
Принадлежит: Hitachi Software Engineering Co Ltd

There will be provided a chemical reaction device and a chemical reaction apparatus capable of performing transverse liquid movement in a simple structure and at low cost without causing contamination and air bubbles. There will be installed a mechanism for supporting the chemical reaction device in any other position than a center of a turntable which can be rotated, for moving liquid by a centrifugal force due to rotation, and for reversing a direction of the flow path independently of the turntable.

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Номер записи: 55
02-05-2002 дата публикации

Method and device for evaluating chemical reaction processes

Номер: DE10052511A1
Автор: Helmut Blum, Holger Wildt, Ludger Buetfering, Wolf-Dieter Herberg
Принадлежит: Henkel AG and Co KGaA

Disclosed is a system for monitoring chemical reactions, especially for detecting exothermic chemical reactions, comprising a reaction device consisting of a plurality of spatially separated reaction chambers for receiving reaction mixtures, and a dosing device for feeding reaction components of the reaction mixtures into the reaction chambers. The inventive system also comprises at least one sensor device which is sensitive to thermal radiation in order to detect the thermal radiation emitted by the reaction mixtures in the reaction chambers.

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Номер записи: 56
27-07-2011 дата публикации

Sample processing units, systems, and related methods

Номер: EP2347254A2
Автор: Jared J. Drader, Jeffrey C. Smith, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Steven A. Hofstadler
Принадлежит: Ibis Biosciences Inc

Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g. , such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g. , to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

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Номер записи: 57
25-03-2010 дата публикации

Sample processing units, systems, and related methods

Номер: WO2010033627A2
Автор: Jared J. Drader, Jeffrey C. Smith, Jose R. Gutierrez, Paul J. Gleason, Rex O. Bare, Robert D. Miller, Steven A. Hofstadler
Принадлежит: IBIS BIOSCIENCES, INC.

Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g. , such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g. , to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

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Номер записи: 58
07-03-2002 дата публикации

Automated process for isolating and amplifying a target nucleic acid sequence

Номер: US20020028489A1
Автор: Cheryl Jakub, Donald Nieglos, Ernest Hansberry, Glenn Horner, John Kling, Kelly Ammann, Ralph Burns, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 59
21-09-2006 дата публикации

Signal measuring system having a movable signal measuring device

Номер: US20060210433A1
Автор: Byron Knight, Christopher Davis, Florence Li, Gary Lair, Haito Li, Jerzy Macioszek, Robert Heinz, Robert Scalese, Thanh Nguyen
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.

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Номер записи: 60
13-03-2008 дата публикации

Temperature-Controlled Incubator Having A Receptacle Mixing Mechanism

Номер: US20080063573A1
Автор: Kelly Ammann, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 61
29-01-2009 дата публикации

Method for detecting the Presence of A Nucleic Acid in A Sample

Номер: US20090029352A1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hanserry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 62
27-11-2012 дата публикации

Method for agitating the contents of a reaction receptacle within a temperature-controlled environment

Номер: US8318500B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 63
27-01-2009 дата публикации

Automated process for detecting the presence of a target nucleic acid in a sample

Номер: US7482143B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated process for detecting the presence of a target nucleic acid in a sample. The process is performed in a stand-alone unit and includes separating the target nucleic acid from other material present in the sample, engaging a robotic pipettor to combine the separated target nucleic acid and reagents for performing an amplification reaction, and performing an amplification reaction. A product of the amplification reaction is detected as an indication of the presence of the target nucleic acid in the sample.

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Номер записи: 64
02-10-2008 дата публикации

Automated Method for Determining the Presence of a Target Nucleic Acid in a Sample

Номер: US20080241837A1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 65
29-01-2009 дата публикации

Method for simultaneously performing multiple amplification reactions

Номер: US20090029871A1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 66
20-03-2003 дата публикации

Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer

Номер: US20030054542A1
Автор: Ernest Hansberry, Ralph Burns
Принадлежит: Individual

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 67
26-09-2002 дата публикации

Device for agitating the fluid contents of a container

Номер: US20020137194A1
Автор: Ernest Hansberry, Kelly Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 68
08-07-2008 дата публикации

Instrument for detecting light emitted by the contents of a reaction receptacle

Номер: US7396509B2
Автор: Ralph E. Burns
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 69
26-09-2002 дата публикации

Automated diagnostic analyzer and method

Номер: US20020137197A1
Автор: Cheryl Jakub, Donald Nieglos, Ernest Hansberry, Glenn Horner, John Kling, Kelly Ammann, Ralph Burns, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming in analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 70
12-08-2003 дата публикации

Method and apparatus for performing a magnetic separation purification procedure on a sample solution

Номер: US6605213B1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 71
10-06-2008 дата публикации

Multiple ring assembly for providing specimen to reaction receptacles within an automated analyzer

Номер: US7384600B2
Автор: Ernest V. Hansberry, Ralph E. Burns
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 72
01-05-2008 дата публикации

Method for Introducing A Fluid Into A Reaction Receptacle Contained Within A Temperature-Controlled Environment

Номер: US20080102527A1
Автор: Kelly Ammann, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 73
24-04-2008 дата публикации

Method for Agitating the Fluid Contents of A Container

Номер: US20080096214A1
Автор: Ernest Hansberry, Kelly Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 74
17-04-2008 дата публикации

System and Method for Incubating the Contents of A Reaction Receptacle

Номер: US20080089818A1
Автор: Kelly Ammann, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 75
12-03-2009 дата публикации

Method for Agitating the Contents of A Reaction Receptacle Within A Temperature-Controlled Environment

Номер: US20090067280A1
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 76
01-10-2013 дата публикации

Method for detecting the presence of a nucleic acid in a sample

Номер: US8546110B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated method for preparing and amplifying a sequence contained in a nucleic acid present in a sample, the nucleic acid being prepared in a receptacle that is part of a unit that includes a plurality of receptacles and holds a removable contact-limiting element for aspirating a fluid component of the sample from the receptacle.

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Номер записи: 77
29-10-2013 дата публикации

Method for performing an assay with a nucleic acid present in a specimen

Номер: US8569019B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated process for isolating and amplifying a target nucleic acid in a self-contained analyzer.

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Номер записи: 78
29-10-2013 дата публикации

Method for simultaneously performing multiple amplification reactions

Номер: US8569020B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated method for performing multiple nucleic acid amplification procedures in multiple receptacles of a set of receptacles contained in an analyzer.

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Номер записи: 79
28-04-2009 дата публикации

Automated process for detecting the presence of a target nucleic acid in a sample

Номер: US7524652B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated process performed in an analyzer for detecting the presence of a target nucleic acid in a sample. The process includes separating the target nucleic acid from other material present in the sample, performing an amplification reaction to produce an amplification product indicative of the presence of the target nucleic acid in the sample, and detecting the amplification product. The amplification reaction can be performed in an open receptacle vessel, such as a test tube.

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Номер записи: 80
20-07-2004 дата публикации

Transport mechanism

Номер: US6764649B2
Автор: Kelly G. Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 81
11-09-2007 дата публикации

Incubator for use in an automated diagnostic analyzer

Номер: US7267795B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 82
29-04-2014 дата публикации

Method for incubating the contents of a receptacle

Номер: US8709814B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Individual

In a computer-controlled, automated method, a nucleic acid amplification procedure is performed within a prescribed incubation temperature range within an instrument that comprises at least one thermal element situated at a first location of the instrument and an amplification incubator situated at a second, spaced-apart location of the instrument. A receptacle and its contents are exposed to the thermal element for a predetermined period of time at the first location, such that the temperature of the contents of the receptacle is adjusted to approximate the incubation temperature. The receptacle is then moved from the first location and into the amplification incubator, and, in the amplification incubator, a nucleic acid contained in the contents of the receptacle is subjected to the nucleic acid amplification procedure.

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Номер записи: 83
11-11-2014 дата публикации

Method for detecting the presence of a nucleic acid in a sample

Номер: US8883455B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample.

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Номер записи: 84
06-10-2015 дата публикации

Method for detecting the presence of a nucleic acid in a sample

Номер: US9150908B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is used to form a reaction mixture comprising the purified nucleic acid and all reagents required to perform a nucleic acid amplification. Amplification products are synthesized that include a nucleotide sequence contained in the nucleic acid or the complement of the nucleic acid. The amplification products are exposed to a probe in a mixture, where the probe forms a hybrid with one of the amplification products. The formation of the hybrid in the mixture provides an indication of the presence of the nucleic acid in the sample.

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Номер записи: 85
10-05-2005 дата публикации

Automated process for isolating and amplifying a target nucleic acid sequence

Номер: US6890742B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 86
16-06-2005 дата публикации

Automated process for isolating and amplifying a target nucleic acid sequence

Номер: US20050130198A1
Автор: Cheryl Jakub, Donald Nieglos, Ernest Hansberry, Glenn Horner, John Kling, Kelly Ammann, Ralph Burns, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 87
25-12-2012 дата публикации

Temperature-controlled incubator having a receptacle mixing mechanism

Номер: US8337753B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 88
20-10-2005 дата публикации

Method for agitating the fluid contents of a container

Номер: US20050233370A1
Автор: Ernest Hansberry, Kelly Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 89
21-03-2017 дата публикации

Automated analyzer for performing a nucleic acid-based assay

Номер: US9598723B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Individual

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 90
14-07-2009 дата публикации

Automated process for detecting the presence of a target nucleic acid in a sample

Номер: US7560256B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated process for detecting the presence of a target nucleic acid in a sample. The process includes separating the target nucleic acid from other material present in the sample at a first station, transferring the separated target nucleic acid from the first station to a second station using a rotatable transport mechanism, combining the transferred target nucleic acid and reagents for performing an amplification reaction at the second station, and performing an amplification reaction. A product of the amplification reaction is detected as an indication of the presence of the target nucleic acid in the sample.

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Номер записи: 91
14-07-2009 дата публикации

Automated process for detecting the presence of a target nucleic acid in a sample

Номер: US7560255B2
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated process for detecting the presence of a target nucleic acid in a sample. The process includes contacting a sample with a magnetically-responsive solid support and immobilizing a target nucleic acid present in the sample on the solid support. At a first station of an analyzer, the solid support is subjected to a magnetic field and the immobilized target nucleic acid is separated from a non-immobilized component of the sample. A solution comprising the separated target nucleic acid is moved to an incubator of a second station of the analyzer, where the separated target nucleic acid is subjected to an amplification procedure and an amplification product is formed. The amplification product is detected as an indication of the presence of the target nucleic acid in the sample.

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Номер записи: 92
29-01-2009 дата публикации

Automated System for Isolating, Amplifying, and Detecting a Target Nucleic Acid Sequence Present in a Fluid Sample

Номер: US20090029877A1
Автор: Cheryl A. Jakub, Donald J. Nieglos, Ernest V. Hansberry, Glenn A. Horner, John E. Kling, Kelly G. Ammann, Ralph E. Burns, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 93
23-02-2010 дата публикации

Method for agitating the fluid contents of a container

Номер: US7666602B2
Автор: Ernest V. Hansberry, Kelly G. Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 94
05-01-2006 дата публикации

Automated process for isolating and amplifying a target nucleic acid sequence

Номер: US20060003373A1
Автор: Cheryl Jakub, Donald Nieglos, Ernest Hansberry, Glenn Horner, John Kling, Kelly Ammann, Ralph Burns, Robert Schneider, Robert Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 95
13-11-2012 дата публикации

Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment

Номер: US8309358B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 96
23-02-2010 дата публикации

Method for agitating the fluid contents of a container

Номер: US7666681B2
Автор: Ernest V. Hansberry, Kelly G. Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 97
06-09-2011 дата публикации

Temperature-controlled incubator having rotatable door

Номер: US8012419B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 98
14-11-2006 дата публикации

Device for agitating the fluid contents of a container

Номер: US7135145B2
Автор: Ernest V. Hansberry, Kelly G. Ammann
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 99
20-03-2012 дата публикации

Temperature-controlled incubator having an arcuate closure panel

Номер: US8137620B2
Автор: Kelly G. Ammann, Robert E. Schneider, Robert J. Smith
Принадлежит: Gen Probe Inc

An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

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Номер записи: 100