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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 108094. Отображено 100.
05-01-2012 дата публикации

Novel fructosyl peptide oxidase

Номер: US20120003678A1
Автор: Kazuo Aisaka, Keiko Suzuki, Toshiko Aisaka
Принадлежит: Kyowa Medex Co Ltd

A protein described in any one of [1] to [4] below is provided according to the present invention: [1] a protein comprising the amino acid sequence represented by SEQ ID NO: 1; [2] a protein comprising an amino acid sequence with one or more amino acid deletions, substitutions, or additions in the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; [3] a protein comprising an amino acid sequence having 80% or higher homology to the amino acid sequence represented by SEQ ID NO: 1, and having fructosyl peptide oxidase activity; and [4] a protein having fructosyl peptide oxidase activity, which is produced by an expression plasmid harbored by the Escherichia coli XL1-Blue MRF' strain deposited under Accession No. FERM BP-11026.

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Номер записи: 1
05-01-2012 дата публикации

Gene expression markers of oncolytic virus sensitivity

Номер: US20120004119A1
Автор: Lynda Chin, Marc Lenburg
Принадлежит: Lynda Chin, Marc Lenburg

A method of predicting an efficacy of an oncolytic virus treatment for a tumor comprises calculating a single-gene predictor score for each of a plurality of genes; calculating a predictor score from the sum of the single-gene predictor scores for the plurality of genes; and predicting, if the predictor score is greater than a predictor score threshold, that the treatment would have efficacy, and if the predictor score is less than a predictor score threshold, that the treatment would lack efficacy. Also, methods of predicting an efficacy of a treatment for a tumor comprise identifying the type and subtype of the tumor, wherein the efficacy of the treatment for the type and subtype of the tumor is known.

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Номер записи: 2
05-01-2012 дата публикации

Materials and methods for treatment of cancer and identification of anti-cancer compounds

Номер: US20120004169A1
Автор: Richard Jove, Said M. Sebti
Принадлежит: UNIVERSITY OF SOUTH FLORIDA

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.

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Номер записи: 3
12-01-2012 дата публикации

Methods of predicting responsiveness to interferon treatment and treating hepatitis c infection

Номер: US20120009148A1
Автор: Yoav Smith
Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Provided are methods of predicting responsiveness of a subject to interferon treatment, comprising comparing a level of expression in a cell of the subject of at least one gene selected from the group consisting KIR3DL3, KIR3DL2, KIR3DL1, KIR2DL1, KIR2DL2, KIR2DL3, KLRG1, KIR3DS1, CD160, HLA-A, HLA-B, HLA-C, HLA-F, HLA-G and IFI27 to a reference expression data of the at least one gene obtained from at least one interferon responder subject and/or at least one interferon non-responder subject. Also provided are methods and pharmaceutical compositions for treating a subject in need of interferon treatment.

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Номер записи: 4
12-01-2012 дата публикации

Differentiating cardiac- and diabetes mellitus-based causes of kidney damage

Номер: US20120009607A1
Автор: Andrea Horsch, Dietmar Zdunek, Georg Hess
Принадлежит: Roche Diagnostics Operations Inc

Disclosed is a method for differentiating in a subject suffering from kidney damage between kidney damage caused by (i) heart failure and/or (ii) diabetes mellitus type 1 or type 2 including the steps of: a) determining the amount of liver-type fatty acid binding protein (L-FABP) and the amount of kidney injury molecule 1 (KIM-1) in a urine-sample of a subject and forming the L-FABP/KIM-1 ratio; b) determining the amount of adiponectin in a urine-sample of said subject; and c) comparing the ratio determined in a) and the amount determined in b) with reference amounts, and establishing the predominant cause of the kidney damage. Also disclosed are a device and a kit for carrying out the method.

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Номер записи: 5
12-01-2012 дата публикации

Devices and methods for detecting amniotic fluid in vaginal secretions

Номер: US20120009609A1
Автор: Alexandr Konstantinov, Boris Fuks, Dmitrii D. Petrunin, Evgeny I. Zaraisky, Margarita I. Marshiskaia, Marina N. Boltovskaya, Nelly A. Starosvetskaya, Svetlana V. Nazimova
Принадлежит: N Dia Inc

The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.

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Номер записи: 6
12-01-2012 дата публикации

Novel uses of vegfxxxb

Номер: US20120010138A1
Автор: Andrew Salmon, David Owen Bates, Steven James Harper
Принадлежит: University of Bristol

The invention provides VEGF xxx b, or an agent which selectively promotes the expression of VEGF xxx b in preference to VEGF xxx in cells of a subject or in vitro, or an expression vector system which causes the expression of the VEGF xxx b in a host organism, for use in treating or preventing microvascular hyperpermeability disorders, or in regulating the pro-angiogenic pro-permeability properties of VEGF xxx isoforms, or in supporting epithelial cell survival without increased permeability, or in reducing the nature (for example the number density and/or size) of fenestrations of epithelial filtration membranes in vivo or in vitro.

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Номер записи: 7
19-01-2012 дата публикации

Mek mutations conferring resistance to mek inhibitors

Номер: US20120015973A1
Автор: Carlos Garcia Echeverria, Caroline Emery, Levi A. Garraway
Принадлежит: Dana Farber Cancer Institute Inc, NOVARTIS AG

The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.

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Номер записи: 8
26-01-2012 дата публикации

Methods and compositions for liver cancer therapy

Номер: US20120020961A1
Автор: Anne-Sophie Dume, Dominique Joubert, Frédéric HOLLANDE, Leïla Houhou
Принадлежит: Biorealites SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, Institut National de la Sante et de la Recherche Medicale INSERM

The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin therapy for liver cancer, and compositions useful therefore.

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Номер записи: 9
26-01-2012 дата публикации

Diagnostic assays for prostate cancer using psp94 and psa biomarkers

Номер: US20120021925A1
Автор: Douglas Barker, Katrin Atnikov, Stephen Frost, Yilan Zhang
Принадлежит: Miraculins Inc

The application refers to a method for diagnosing prostate cancer through the measurement of the combination of PSP94 (β-microseminoprotein) and F/T PSA biomarkers, the method using urine samples to measure PSP94 and serum samples to analyse F/T PSA. In one embodiment, the PSP94 is standardized to creatinine. Also based on the measurement of PSP94 and F/T PSA are provided methods and kits for (a) diagnosing aggressive prostate cancer; (b) differential diagnosis; and (c) diagnosing the progression of prostate cancer.

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Номер записи: 10
26-01-2012 дата публикации

Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium atpase and phospholamban

Номер: US20120021926A1
Автор: David D. Thomas, Krisztina M. Zsebo, Razvan L. Cornea
Принадлежит: Individual

Provided herein are methods for identifying molecules capable of modulating SERCA, the SERCA-PLB complex or the microenvironment of the complex. An exemplary assay provided herein is fluorescence resonance energy transfer (FRET). Also provided herein are FRET assays that are optimized for high-throughput screening (HTS) for identifying small molecules that modulate SERCA or the SERCA-PLB complex. Further provided are kits for carrying out said methods for identifying molecules.

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Номер записи: 11
02-02-2012 дата публикации

Modified heparinase iii and methods of sequencing therewith

Номер: US20120027744A1
Автор: Dongfang Liu, Ganesh Venkataraman, Kevin Pojasek, Kristine Holley, Ram Sasisekharan, Yosuf El-Shabrawi, Zachary Shriver
Принадлежит: Massachusetts Institute of Technology

The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.

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Номер записи: 12
02-02-2012 дата публикации

Cell lines expressing guanylate cyclase-c and methods of using them

Номер: US20120028278A1
Автор: Jessica Langer, Kambiz Shekdar
Принадлежит: Chromocell Corp

Cell lines that stably express GC-C and methods for using those cell lines are disclosed herein. The invention includes cell lines that express GC-C and techniques for creating cell lines. The GC-C-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results in cell-based assays, e.g., high throughput screening assays.

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Номер записи: 13
02-02-2012 дата публикации

Whitefly Ecdysone Receptor Nucleic Acids, Polypeptides, and Uses Thereof

Номер: US20120028300A1
Автор: Dean Ervin Cress, Jianzhong Zhang, Subba Reddy Palli, Tarlochan Singh Dhadialla
Принадлежит: Intrexon Corp

The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation system and methods for identifying molecules that modulate whitefly ecdysone receptor activity.

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Номер записи: 14
09-02-2012 дата публикации

Diagnosis of benign and cancerous growths by measuring circulation tumor stem cells and serum annexina2

Номер: US20120034627A1
Автор: Pomila Singh
Принадлежит: University of Texas System

Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing the presence of early stage primary cancer from advanced stage metastatic cancer in the subject by measuring and detecting AnnexinA2, CS-ANXA2 and DCAMKL−1 or Lgr5 in the blood or plasma. In addition, there is provided a method for distinguishing the presence of benign, pre-cancerous tumorous growths or cancerous tumors in the subject by measuring and detecting AnnexinA2 and circulating tumor stem cells positive for CS-ANXA2 and DCAMKL or CS-ANXA2 and Lgr5 in the blood or plasma.

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Номер записи: 15
09-02-2012 дата публикации

Method for assessing inflammatory condition

Номер: US20120034706A1
Автор: Chihiro Miyazawa, Kyoko Miyamoto, Nobuhito Masuda, Yukio Sudo, Yukitaka Ueki
Принадлежит: HAKUJYUJIKAI MEDICAL Inc, Perseus Proteomics Inc

Provided a method for correctly assessing an inflammatory condition of a patient who is receiving a therapy with an IL-6 inhibitor. The method for assessing an inflammatory condition of a patient who is receiving an IL-6 inhibitor, including determining a PTX3 level of a sample derived from a patient who is receiving an IL-6 inhibitor.

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Номер записи: 16
16-02-2012 дата публикации

Anti-Hemagglutinin Antibody Compositions And Methods Of Use Thereof

Номер: US20120039899A1
Автор: Andres G. Grandea, III, Christina L. Boozer, Ole Olsen
Принадлежит: Theraclone Sciences Inc

The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.

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Номер записи: 17
16-02-2012 дата публикации

Identification of Porcine Reproductive and Respiratory Syndrome Virus

Номер: US20120040335A1
Автор: Craig Welbon, Elizabeth M. Brown, Eric A. Nelson, Ying Fang
Принадлежит: South Dakota State University

An enzyme-linked immunosorbent assay (ELISA) is based on the non-structural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) and provides for the simultaneous detection and differentiation of serum antibodies directed against Type 1 (European) and Type 2 (North American) PRRSV. The invention provides a serological assay for the detection and/or differentiation of serum antibodies directed against Type 1 and/or Type 2 PRRSV utilizing PRRSV nsp7 as an antigen, and provides a diagnostic method for the detection of PRRSV infection, epidemiological surveys, and outbreak investigations. The invention may be used either alone or as a follow-up assay to determine the true status of unexpected positive results that may occur using other assays, such as the IDEXX HERDCHEK PRRS ELISA.

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Номер записи: 18
23-02-2012 дата публикации

Engineered anti-il-13 antibodies, compositions, methods and uses

Номер: US20120045438A1
Автор: Alexey V. Teplyakov, Ellen Chi, Gopalan Raghunathan, Hong Mimi Zhou, Jill Giles-Komar, Jill M. Carton, Johan Fransson, Juan C. Almagro, Karyn T. O'neil, Linus Hyun, Ronald V. Swanson, Shanrong Zhao, Wendy Cordier, Yiqing Feng
Принадлежит: Centocor Ortho Biotech Inc

The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.

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Номер записи: 19
23-02-2012 дата публикации

Releasable nonvolatile mass-label molecules

Номер: US20120046180A1
Автор: Christopher H. Becker, Daniel J. Pollart, Joseph A. Monforte, Thomas A. Shaler
Принадлежит: Sequenom Inc

Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents.

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Номер записи: 20
23-02-2012 дата публикации

TNF-alpha Antagonists Containing IGFBP5

Номер: US20120046217A1
Автор: Jae-ho Huh, Jae-Ryoung Hwang, Je-Ho Lee
Принадлежит: Sungkyunkwan University Foundation For Corporate Collaboration

The present invention relates to: TNF-α antagonists containing IGFBP5 protein, variants thereof, or fragments thereof; and the use of the TNF-α antagonists. More specifically, the present invention relates to: a polynucleotide encoding the protein, variants thereof, or fragments thereof; a vector containing the polynucleotide; a transformant containing the vector; and a method for screening a therapeutic agent for TNF-α overexpression-related diseases by checking whether the mutual reaction thereof is facilitated after treating with candidates to the cell expressing the IGFBP5 protein, variants thereof, or fragments thereof, and the TNER1.

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Номер записи: 21
01-03-2012 дата публикации

Methods of diagnosing cervical cancer

Номер: US20120052484A1
Автор: Chamorro Somoza Diaz-Sarmiento, Johannes Schweizer, Michael P. Belmares, Peter S. Lu
Принадлежит: Individual

The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus E6 proteins in clinical samples.

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Номер записи: 22
01-03-2012 дата публикации

Photodamage mitigation compounds and systems

Номер: US20120052488A1
Автор: Andrei Fedorov, John Lyle, Robert Weber, Stephen Yue, Xiangxu Kong
Принадлежит: Pacific Biosciences of California Inc

Compositions, devices, systems and methods for reducing and/or preventing photo-induced damage of one or more reactants in an illuminated analytical reaction by addition of one or more photoprotective compounds to the reaction mixture and allowing the reaction to proceed for a period that is less than a photo-induced damage threshold period.

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Номер записи: 23
01-03-2012 дата публикации

Cyanine dyes

Номер: US20120052506A1
Автор: David Sun, Gene Shen, Stephen Yue
Принадлежит: Pacific Biosciences of California Inc

The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties of the dyes. Also provided are conjugates of the dyes, methods of using the dyes and their conjugates and kits including the dyes and their conjugates.

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Номер записи: 24
01-03-2012 дата публикации

Phospholinked dye analogs with an amino acid linker

Номер: US20120052507A1
Автор: Gene Shen
Принадлежит: Pacific Biosciences of California Inc

In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including muliple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.

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Номер записи: 25
08-03-2012 дата публикации

Anti- integrin antibodies, compositions, methods and uses

Номер: US20120058128A1
Автор: Jill Giles-Komar, Linda Snyder, Marian T. Nakada, Mohit Trikha
Принадлежит: Janssen Biotech Inc

The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

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Номер записи: 26
08-03-2012 дата публикации

Differential immunoassay for prrs vaccine antibody

Номер: US20120058466A1
Автор: Kyoung-Jin Yoon, Wai-Hong Wu
Принадлежит: Iowa State University Research Foundation ISURF

The present invention relates to immunoassays for serologically differentiating animals naturally infected with PRRS virus from animals vaccinated against PRRS. The immunoassays provide detection of at least a portion of the N terminal region of the 2b portion of PRRSV. The immunoassay is preferably an enzyme-linked immunosorbent assay (ELISA).

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Номер записи: 27
08-03-2012 дата публикации

Oxidized glutathione assay

Номер: US20120058501A1
Автор: Dieter Klaubert, Fen Huang, John Shultz, Wenhui Zhou
Принадлежит: Promega Corp

The present invention provides an assay for detection of oxidized glutathione (GSSG).

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Номер записи: 28
15-03-2012 дата публикации

Psca: prostate stem cell antigen and uses thereof

Номер: US20120063999A1
Автор: Aya Jakobovitz, Douglas C. Saffran, Owen N. Witte, Robert E. Reiter
Принадлежит: Agensys Inc, UNIVERSITY OF CALIFORNIA

The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

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Номер записи: 29
15-03-2012 дата публикации

Monoclonal Antibodies to Hepatocyte Growth Factor

Номер: US20120064066A1
Автор: Kyung Jin Kim, Yi-Chi Su
Принадлежит: Galaxy Biotech LLC

The present invention is directed toward a neutralizing monoclonal antibody to hepatocyte growth factor, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.

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Номер записи: 30
15-03-2012 дата публикации

Il-17 homologous polypeptides and therapeutic uses thereof

Номер: US20120064073A1
Автор: Audrey Goddard, Austin L. Gurney, Colin K. Watanabe, Daniel G. Yansura, Daniel Tumas, Dorothy French, Ellen Fllvaroff, Hanzhong Li, J. Christopher Grimaldi, James Pan, Jian Chen, Kenneth J. Hillan, Melissa A. Starovasnik, Menno Van Lookeren, P. Mickey Williams, Paul J. Godowski, Richard Vandlen, Sarah G. Hymowitz, Sherman Fong, William I. Wood
Принадлежит: Individual

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

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Номер записи: 31
15-03-2012 дата публикации

Use of Serum Amyloid A Gene in Diagnosis and Treatment of Glaucoma and Identification of Anti-Glaucoma Agents

Номер: US20120064532A1
Автор: Abbot F. Clark, Loretta Graves Mcnatt, Wan-Heng Wang
Принадлежит: NOVARTIS AG

The present invention provides compositions and methods for treating glaucoma, methods for diagnosing glaucoma, and methods for identifying agents which may be useful in the treatment of glaucoma. More specifically, the present invention describes the use of agents that modulate the expression of serum amyloid A.

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Номер записи: 32
15-03-2012 дата публикации

Methods and kits for diagnosing osteoarthritis and predicting progression

Номер: US20120065094A1
Автор: Mukundan Attur, Steven B. Abramson
Принадлежит: New York University NYU

This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject.

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Номер записи: 33
15-03-2012 дата публикации

Use of the gtpase rab27b to diagnose and treat poor prognosis estrogen-receptor-positive breast cancer

Номер: US20120065147A1
Автор: An Hendrix, Olivier De Wever, Wendy Westbroek
Принадлежит: Individual

The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit comprising an assay for measuring Rab27B levels in said patients and to the usage of Rab27B as a target to screen for drugs capable of inhibiting or diminishing metastasis of said cancer. Furthermore, the invention discloses compounds which can be used to treat estrogen receptor-positive breast cancer.

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Номер записи: 34
15-03-2012 дата публикации

Predicting risk of major adverse cardiac events

Номер: US20120065897A1
Автор: Eugene R. Heyman, James V. Snider
Принадлежит: Critical Care Diagnostics Inc

Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure.

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Номер записи: 35
15-03-2012 дата публикации

Identification of a jak2 mutation involved in vaquez polyglobulia

Номер: US20120066776A1
Автор: Chloe James, Jean-Pierre Le Couedic, Nicole Casadevall, Valerie Ugo, William Vainchenker
Принадлежит: Assistance Publique Hopitaux de Paris APHP, IGR&D SA, Institut National de la Sante et de la Recherche Medicale INSERM

The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.

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Номер записи: 36
22-03-2012 дата публикации

Fluorescent conjugated polymers with a bodipy-based backbone and uses thereof

Номер: US20120070382A1
Автор: Haiying Liu
Принадлежит: MICHIGAN TECHNOLOGICAL UNIVERSITY

The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.

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Номер записи: 37
22-03-2012 дата публикации

Humanized antibodies against west nile virus and therapeutic and prophylactic uses thereof

Номер: US20120070429A1
Автор: Leslie S. Johnson, Ling Huang
Принадлежит: Macrogenics Inc

The present invention relates to compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to one or more antigens of a flavivirus, particularly of West Nile Virus (WNV) and methods for preventing, treating or ameliorating symptoms associated with a flavivirus, particularly of West Nile Virus (WNV) infection utilizing said compositions. In particular, the present invention relates to methods for preventing, treating or ameliorating symptoms associated with WNV infection, said methods comprising administering to a human subject an effective amount of one or more humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen. The present invention also relates to detectable or diagnostic compositions comprising humanized antibodies or fragments thereof that immunospecifically bind to a WNV antigen and methods for detecting or diagnosing WNV infection utilizing said compositions.

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Номер записи: 38
22-03-2012 дата публикации

Extracellular yaluronidase from streptomyces koganeiensis

Номер: US20120070441A1
Автор: Giovanni Gennari, Luciano Messina, Salvatore Caruso, Susana Vaccaro
Принадлежит: KETER PLASTIC LTD

The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.

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Номер записи: 39
22-03-2012 дата публикации

Methods And Marker Combinations For Screening For Predisposition To Lung Cancer

Номер: US20120071334A1
Автор: Bhawani Singh, Eric L. Russell, Javier Ramirez, John C. Russell, Stephen Frost, Tracey Colpitts
Принадлежит: ABBOTT LABORATORIES

The present invention relates to rapid, sensitive methods for determining whether a subject has or is at risk of developing lung cancer based on certain combinations of biomarkers, or biomarkers and biometric parameters. The methods consist of: a) quantifying in a test sample obtained from a subject, the amount of two or more biomarkers in a panel, the panel comprising at least one antibody and at least one antigen: b) comparing the amount of each biomarker quantified in the panel to a predetermined cutoff for said biomarker and assigning a score for each biomarker based on said comparison: c) combining the assigned score for each biomarker quantified in step b to obtain a total score for said subject: d) comparing the total score in step c with a predetermined total score and e) determining whether said subject has a risk of lung cancer based on the comparison in step d.

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Номер записи: 40
22-03-2012 дата публикации

Compositions and methods for identifying enzyme and transport protein inhibitors

Номер: US20120071344A1
Автор: Roland Wolkowicz
Принадлежит: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION

The invention is directed to compositions, e.g., cell-based and multiplexed platforms, to screen for small molecule drugs that inhibit enzymes such as proteases, e.g., viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., viral proteases such as HIV proteases. In alternative embodiments, the invention provides cell-based platforms or assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelope protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products. In one embodiment, the invention provides a cell-based or multiplexed platform for monitoring the activity of enzymes, e.g., proteases such as viral proteases.

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Номер записи: 41
22-03-2012 дата публикации

Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor

Номер: US20120071422A1
Автор: Grant Gallagher, Jonathan Brazaitis, Raymond Yu
Принадлежит: Medical Diagnostic Laboratories LLC

The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα protein, which is lacking a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end (due to frame-shift). ELISA reveals that Δ9 is present in blood and can serve as a diagnostic tool for auto-immune diseases including Crohn's disease. There is also provided a method of recombinant production for this soluble truncated form of IL-23Rα protein. More importantly, the present invention provides an utility application of the Δ9 and Δ8,9 protein in inhibit IL-23R-mediated cell signaling. More particularly, Δ9 and Δ8,9 blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of Δ9 and Δ8,9 in treating a human patient inflicted with Crohn's disease.

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Номер записи: 42
29-03-2012 дата публикации

Electrochemical method and apparatus of identifying the presence of a target

Номер: US20120073987A1
Автор: Heinz-Bernhard Kraatz, Kagan Kerman
Принадлежит: Individual

An electrochemical method of identifying the presence of a target protein in a sample is provided. The method comprises providing a redox probe modified to include a detector that is suitable to bind to the target protein, and exposing the sample to the detector-modified redox probe. A change in the electrochemical signal produced by the redox probe as compared to a control signal is indicative of the presence of the target protein.

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Номер записи: 43
29-03-2012 дата публикации

Method for Detecting and Quantitating Multiple-Subcellular Components

Номер: US20120075453A1
Автор: Michael Kilpatrick, Triantafyllos Tafas
Принадлежит: Ikonisys Inc

A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.

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Номер записи: 44
29-03-2012 дата публикации

Compartment-Specific Non-HLA Targets for Diagnosis and Prediction of Graft Outcome

Номер: US20120077689A1
Автор: Atul J. Butte, Minnie M. Sarwal
Принадлежит: Leland Stanford Junior University

Methods and composition are provided for diagnosing or predicting the status or the outcome of a graft transplant. In some embodiments, the presence or absence of one or more proteins recognizing a non-HLA/non ABO antigen is determined. The obtained result is then employed to diagnose or predict the status or outcome of the graft transplant. Also provided are compositions, systems and kits that find use in practicing the subject methods.

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Номер записи: 45
29-03-2012 дата публикации

Treatment of Central Nervous System Disorders

Номер: US20120077741A1
Автор: Ann Marie Janson, Anne Schanzer, Frank-Peter Wachs, H. Georg Kuhn, Karlheinz Plate, Kioumars Delfani, Ming Zhao
Принадлежит: NeuroNova AB

The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.

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Номер записи: 46
29-03-2012 дата публикации

Use of a growth-stimulating protein

Номер: US20120077750A1
Автор: Jukka Westermarck, Melissa Junttila, Pietri Puustinen
Принадлежит: Jukka Westermarck, Melissa Junttila, Pietri Puustinen

This invention relates to the inhibition of a newly discovered growth-stimulating protein in an individual. Further, the invention relates to a method for preventing or treating a cancer, or preventing or treating cancer growth, invasion or metastasis, or preventing or treating other hyperproliferative diseases in an individual, by down regulating the expression of said growth-stimulating protein or by inactivating said protein. Still further, the invention concerns a method for diagnosing cancer or other hyperproliferative diseases in an individual based on said growth-stimulating protein.

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Номер записи: 47
05-04-2012 дата публикации

Equine parasite detection

Номер: US20120082992A1
Автор: Christopher Proudman, Jacqui Matthews, Jane Hodgkinson
Принадлежит: MOREDUN RESEARCH INSTITUTE

The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.

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Номер записи: 48
05-04-2012 дата публикации

Myostatin binding agents

Номер: US20120083442A1
Автор: Hosung Min, Hq Han, Thomas Charles Boone
Принадлежит: AMGEN INC

The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.

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Номер записи: 49
12-04-2012 дата публикации

Therapeutics for age-related macular degeneration

Номер: US20120087928A1
Автор: Kameran Lashkari
Принадлежит: Individual

The invention provides compositions and methods of predicting a subject's risk of developing age-related macular degeneration (AMD) and methods of treating, delaying, or preventing the development and progression of AMD.

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Номер записи: 50
12-04-2012 дата публикации

Methods of diagnosing insulin resistance and sensitivity

Номер: US20120088245A1
Автор: Anny Xiang, Jerome I. Rotter, Kent D. Taylor, Leslie Raffel, Mark O. Goodarzi, Thomas A. Buchanan, Xiuqing Guo, Yii-Der I. Chen
Принадлежит: Cedars Sinai Medical Center

Methods of diagnosing susceptibility to metabolic insulin resistance and other related conditions are disclosed. The method provides means of diagnosing susceptibility to insulin resistance in Hispanic Americans by determining the presence of a risk haplotype at the LPL locus, the LPIN1 locus, and/or elevated levels of gamma-glutamyl transferase.

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Номер записи: 51
12-04-2012 дата публикации

Inhibitors of protein tyrosine phosphatases

Номер: US20120088720A1
Автор: Sheng Zhang, Zhong-Yin Zhang
Принадлежит: Indiana University Research And Technology Corp

Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

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Номер записи: 52
19-04-2012 дата публикации

Self-exciting, self-sensing piezoelectric cantilever sensor for detection of airborne analytes directly in air

Номер: US20120094270A1
Автор: David L. de Lesdernier, David R. Maraldo, Gossett Augustus Campbell, Peter A. Nagy, Rajakkannu Mutharasan
Принадлежит: DREXEL UNIVERSITY

A method for detection of airborne biological agent using a piezoelectric cantilever sensor that includes a piezoelectric layer and a non-piezoelectric layer. A recognition entity is placed on one or both of the two layers. The antibody that recognizes and binds to the airborne species may be chemically immobilized on the cantilever sensor surface. In one embodiment, the cantilever sensor is attached to a base at only one end. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form a piezoelectric cantilever beam sensor. In this embodiment, resonance is measured via stress on the piezoelectric layer and it has been demonstrated that such sensors are robust and exhibit excellent sensing characteristics in gaseous media with sufficient sensitivity to detect airborne species at relatively low concentrations.

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Номер записи: 53
19-04-2012 дата публикации

Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases

Номер: US20120094280A1
Автор: Edita Kriukiene, Saulius Klimasauskas, Zita Liutkeviciute
Принадлежит: BIOTECHNOLOGIJOS INSTITUTAS

The present invention relates to a use of non-cofactor compounds, represented by formulas (I) or (II) wherein R and Z are independently selected from H, D, C 1 -C 12 -alkyl, preferably C 1 -C 4 -alkyl, alkenyl, alkinyl, phenyl or -LX, wherein X represents a functional group or a reporter group attached via a linker group L, and QH is selected from —SH, —SeH, —NHNH 2 or —ONH 2 , for a targeted modification or derivatization of a biomolecule by covalent coupling to the biomolecule in the presence of a directing methyltransferase. Further development of the method of targeted modification and derivatization are the method for targeted labeling a biomolecule and method for detecting unmethylated target sites in a biomolecule comprising modification of the biomolecule according to the present invention.

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Номер записи: 54
19-04-2012 дата публикации

Methods of diagnosis and treatment of melanoma

Номер: US20120095078A1
Автор: Ze'ev Ronai
Принадлежит: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

Methods for the diagnosis or prognosis of melanoma by detecting expression of ATF2 and MITF in melanocytes are provided herein. Also provided are methods of treating a melanocyte proliferative disorder with agents that modulate the transcriptional activity of ATF2 and/or MITF activity.

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Номер записи: 55
26-04-2012 дата публикации

Compositions comprising semaphorins for the treatment of angiogenesis related diseases and methods of selection thereof

Номер: US20120101029A1
Автор: Asya Varshavsky, Boaz Kigel, Gera Neufeld, Ofra Kessler
Принадлежит: Rappaport Family Institute for Research in the Medical Sciences

A method of selecting a semaphorin for treating cancer in a subject is disclosed. The method comprises determining an expression of a semaphorin receptor on tumor cells of a tumor sample of the subject wherein an amount of the semaphorin receptor is indicative of the semaphorin suitable for treating the cancer in the subject. Methods of treating angiogenesis, kits for treating cancer and pharmaceutical compositions comprising semaphorins are also disclosed.

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Номер записи: 56
26-04-2012 дата публикации

Method for screening inhibitor for inhibiting interaction between beta-amyloid peptide and vegf and inhibitor searched by the same

Номер: US20120101284A1
Автор: Chan-Won Park, In-Cheol Kang
Принадлежит: Innopharmascreen Inc

There is provided a compound found by screening a material for inhibiting a binding between a beta-amyloid 1-42 peptide and VEGF165, in which the inhibition material screened according to the present invention can improve effectiveness as a material for treating Alzheimer's disease.

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Номер записи: 57
03-05-2012 дата публикации

Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method

Номер: US20120107342A1
Автор: Bernard Adri Bokhout, Florine Johanna Van Milligen, Johannes Bernardus Wilhelmus Joseph Cornelissen
Принадлежит: Stichting Dienst Landbouwkundig Onderzoek DLO

Described is an ex vivo animal or challenge model used as a method to identify protective (e.g., recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. Further described are vaccines directed against infection with parasites, such as Fasciola hepatica , which vaccines contain protective (recombinant) proteins identified and shown to be protective in studies using the ex vivo model. Further described are protective (e.g., recombinant) proteins obtained from newly excysted juveniles (NEJ) of F. hepatica . The protective (recombinant) protein corresponding to an NEJ protein has an apparent molecular weight of 32 kD and an N-terminal amino acid molecule comprising the sequence XXDVSWPFWDRMYNY (SEQ ID NO:1).

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Номер записи: 58
03-05-2012 дата публикации

Anti bone-loss and anti attachment-loss effects of an oral composition

Номер: US20120107843A1
Автор: Emi Shimizu, Harsh M. Trivedi, Nicola C. Partridge, Tao Xu, Virginia Barnes, Wei Wang
Принадлежит: Colgate Palmolive Co

Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein.

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Номер записи: 59
10-05-2012 дата публикации

Tslp promotes immune evasion and persistence of viruses

Номер: US20120114596A1
Автор: Bernhard Homey, Isabel Fernandez, Vassili Soumelis
Принадлежит: HEINRICH-HEINE-UNIVERSITAET, INSTITUT CURIE, Institut National de la Sante et de la Recherche Medicale INSERM

It relates to the treatment or prevention of a chronic viral infection with a Thymic Stromal Lymphopoietin (TSLP) antagonist thereby avoiding immune evasion and persistence of the virus. It also provides a method of prognosing the evolution of a cervical dysplasia by TSLP expression in a sample of said cervical dysplasia.

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Номер записи: 60
10-05-2012 дата публикации

Ifn-alpha/beta-independent mechanism of antiviral protection through a novel ligand-receptor pair: ifn- ligands engage a novel receptor ifn-rn (crf2-12) and il-10r2 (crf2-4) for signaling andinduction of biological activities

Номер: US20120114603A1
Автор: Grant F. Gallagher, Sergei Kotenko
Принадлежит: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

A novel IFN-α/β independent ligand receptor system which upon engagement leads, among other things, to the establishment of an anti-viral state is disclosed. Further disclosed are three closely positioned genes on human chromosome 19 that encode distinct but highly homologous proteins, designated IFN-λ1, IFN-λ2, IFN-λ3, based, inter alia, in their ability to induce antiviral protection. Expression of these proteins is induced upon viral infection. A receptor complex utilized by all three IFN-λ proteins for signaling is also disclosed. The receptor complex is generally composed of two subunits, a novel receptor designated IFN-λR1 or CRF2-12, and a second subunit, IL-10R2 or CRF2-4, which is also a shared receptor component for the IL-10 and IL-22 receptor complexes. The gene encoding IFN-λR1 is generally widely expressed, including many different cell types and tissues. Expression of these proteins is induced by immune events, including, for example, upon viral infection. Apoptotosis may also be induced under effective conditions.

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Номер записи: 61
10-05-2012 дата публикации

Methods Of Renal Cancer Detection

Номер: US20120115747A1
Автор: Evan David Kharasch, Jeremiah J. Morrissey
Принадлежит: Washington University in St Louis WUSTL

Disclosed are methods for detecting, diagnosing or monitoring a renal cancer in a subject. The methods include detecting quantity of one or more polypeptides or fragments thereof comprised by body fluid such as urine, wherein the one or more polypeptides or fragments thereof, can be present at elevated levels in a subject with a kidney cancer, as compared to a subject without a kidney cancer. Non-limiting examples of such polypeptides include aquaporin-1, adipose differentiation-related protein and paired box protein-2. Antibody probes can be used to detect or quantify the polypeptides. In some embodiments, mass spectroscopy can be used to detect or quantify the polypeptides, or to identify a polypeptide in a body fluid sample from a subject with a kidney cancer.

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Номер записи: 62
17-05-2012 дата публикации

Test for Predicting Neutralization of Asparaginase Activity

Номер: US20120121570A1
Автор: Yann Godfrin
Принадлежит: Individual

Method of in vitro measurement of the presence of factors that are able to neutralize asparaginase activity in a sample of blood, plasma, serum or derived medium that may contain asparaginase neutralizing factors, obtained from a patient, comprising mixing of said sample with asparaginase, incubation of said mixture, then measurement of the residual asparaginase activity in the mixture and determination or quantification of the presence of said neutralizing factors. Method for predicting the efficacy of a treatment with asparaginase.

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Номер записи: 63
17-05-2012 дата публикации

Treatment of oncostatin m receptor beta mediated heart failure

Номер: US20120121579A1
Автор: Henning Warnecke, Jochen Pöling, Thomas Braun, Thomas Kubin, Wolfgang Rees
Принадлежит: Max Planck Gesellschaft zur Foerderung der Wissenschaften eV

The present invention relates to an inhibitor of the oncostatin M receptor β or an inhibitor of an activator of the oncostatin M receptor β for use in the treatment and/or prevention of heart failure. The present invention also relates to a method of treating and/or preventing heart failure comprising administering a pharmaceutically effective amount of an inhibitor of the oncostatin M receptor β or an inhibitor of an activator of the oncostatin M receptor β to a subject in need thereof. Further, the present invention also relates to methods of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of heart failure.

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Номер записи: 64
17-05-2012 дата публикации

Anti-estrogen and immune modulator combinations for treating breast cancer

Номер: US20120121620A1
Автор: David A. Sirbasku
Принадлежит: Individual

Compositions for treating cancers of mucosal tissues including breast, prostate, ovary, colon are disclosed which include various combinations of new or conventional anti-estrogen compounds, aromatase inhibitors, immune modulators, immune inhibitors, immune inhibitor mimicking compounds and steroid or thyroid hormones. Methods of predicting susceptibility of a cancer of mucosal origin to treatment with a composition containing an immune inhibitor or an immune inhibitor mimicking compound are also disclosed. Preferred methods include identifying in a specimen of cancer cells the presence of a Poly-Ig (Fe) receptor or Poly-Ig-like (Fc) receptor capable of binding to an immune inhibitor or an immune inhibitor mimicking compound and of mediating immune inhibition of cancer cell growth.

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Номер записи: 65
17-05-2012 дата публикации

Agents and Methods Related to Reducing Resistance to Apoptosis-Inducing Death Receptor Agonists

Номер: US20120122724A1
Автор: Robert P. Kimberly, TONG Zhou
Принадлежит: UAB RESEARCH FOUNDATION

Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.

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Номер записи: 66
24-05-2012 дата публикации

Diagnosis and treatment of cancer using anti-tmprss11e antibody

Номер: US20120128678A1
Автор: Hiroyuki Aburatani, Kiyataka Nakano, Shunpei Ishikawa
Принадлежит: Forerunner Pharma Research Co Ltd, University of Tokyo NUC

[Problem to be Solved] An object of the present invention is to provide novel means for the treatment and diagnosis of cancer. [Solution] The present inventors have obtained a monoclonal antibody against TMPRSS11E and found that this antibody binds to a native form of TMPRSS11E, and TMPRSS11E is highly expressed on the cell membranes of cancer cell lines in flow cytometry. This antibody exhibits antibody-dependent cell-mediated cytotoxicity activity (ADCC activity) and antitumor effect based on internalization activity and is promising as a therapeutic target. Moreover, this antibody has neutralization activity against protease activity and is also expected to have effect brought about by the inhibition of TMPRSS11E functions.

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Номер записи: 67
24-05-2012 дата публикации

Diagnosis and treatment of autoimmune demyelinating diseases

Номер: US20120128698A1
Автор: Menno Van Lookeren Campagne
Принадлежит: F Hoffmann La Roche AG

The present invention concerns the diagnosis and treatment of autoimmune demyelinating diseases, such as multiple sclerosis (MS), by means of a CLM-I agonist.

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Номер записи: 68
24-05-2012 дата публикации

Methods and compositions for protein labeling using lipoic acid ligases

Номер: US20120129159A1
Автор: Alice Y. Ting, Daniel Shao-Chen Liu, David Baker, Florian Richter, Lucas Nivon
Принадлежит: Individual

The present disclosure provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs (e.g., lipoic acid analogs comprising a resorufin moiety) recognized by lipoic acid ligase and lipoic acid ligase mutants. Also provided herein is a method of imaging protein-protein interaction via a reaction mediated by lipoic acid ligase.

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Номер записи: 69
24-05-2012 дата публикации

Methods and compositions for diagnosing ankylosing spondylitis using biomarkers

Номер: US20120129185A1
Автор: Robert L. Wong, Walter P. Maksymowych
Принадлежит: Abbott Biotech Ltd Bermuda

The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.

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Номер записи: 70
24-05-2012 дата публикации

Diagnostical use of peroxiredoxin 4

Номер: US20120129187A1
Автор: Janina Schulte, Joachim Struck
Принадлежит: BRAHMS GmbH

The present invention relates to a method for the diagnosis or prognosis of a disease or clinical condition in a subject comprising the steps of: (i) providing a sample of bodily fluid of a subject, (ii) determining the level of peroxiredoxin 4 (PRX4) or a fragment thereof having at least 20 amino acids residues in length in said sample, and (iii) correlating the level of PRX4 or a fragment thereof with a disease or clinical condition.

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Номер записи: 71
24-05-2012 дата публикации

Marker and reagent for detection of human il-17-producing helper t cells, and method for detection of human il-17-producing helper t cells

Номер: US20120129724A1
Автор: Hirokazu Kurata, Hitoshi Uga, Masafumi Ikeda, Masakazu Kadowaki, Masatoshi Yanagida, SATOSHI Tanaka, Takahiro Okazawa, Yoshiaki Miyamoto
Принадлежит: Sysmex Corp

The present invention relates to a marker allowing specific detection of human IL-17-producing helper T-cells (human Th17 cells), a method for specifically detecting human Th17 cells and a reagent for detecting human Th17 cells.

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Номер записи: 72
24-05-2012 дата публикации

Inhibition of ApoE Cleavage Activity in the Treatment of ApoE-Related Disorders

Номер: US20120129782A1
Автор: Karl H. Weisgraber, Mei Xiu Steele, QIN Xu, Robert W. Mahley, Stephen Barry Freedman, Yadong Huang
Принадлежит: J David Gladstone Institutes

The present invention provides methods for treating apoE-related disorders. The methods generally involve administering an effective amount of an agent that inhibits activity of an enzyme that cleaves apoE.

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Номер записи: 73
24-05-2012 дата публикации

Detection and treatment of autoimmune disorders

Номер: US20120130350A1
Автор: Anne M. Stevens, Neelufar Mozaffarian
Принадлежит: Seattle Childrens Hospital

Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.

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Номер записи: 74
31-05-2012 дата публикации

Method for detecting the presence of target bacteria or a target component carbohydrate antigen thereof

Номер: US20120135420A1
Автор: Elena Valentin Molokova, Mary Kathleen Fent, Norman James Moore, Vladimir Andrei Koulchin
Принадлежит: Binax Inc

A process is disclosed for separating a carbohydrate antigen from a Gram-positive or Gram-negative bacteria in a purified form that contains no more than 10% protein. The separated antigen is coupled to an affinity column, over which polyclonal antibodies to the same bacteria are chromatographed and recovered in a purified form that exhibits high specificity and sensitivity in immunoassays for the raw carbohydrate antigen corresponding to the purified antigen on the column. A particularly preferred form of rapid immunochromatographic assay employing the purified antibodies, which assay is very useful as an aid to rapid diagnosis of diseases caused by bacteria, is disclosed.

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Номер записи: 75
31-05-2012 дата публикации

Biosensors utilizing ink jet-printed biomolecule compatible sol gel inks and uses thereof

Номер: US20120135437A1
Автор: Anne Marie Smith, Carlos Fillipe, John D. Brennan, Julle Marie Lebert, Robert Pelton, Roger Luckham, Zakir Hossaln
Принадлежит: MCMASTER UNIVERSITY

Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from separate nozzles in a layered approach which avoids clogging of the nozzles by the pre-mature gelling of the sol gel precursor solution. In certain embodiments of the application, a capture agent is used to concentrate a compound to be detected in specific areas on the substrate to facilitate detection.

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Номер записи: 76
07-06-2012 дата публикации

Water cooler towers and other man-made aquatic systems as environmental collection systems for agents of concern

Номер: US20120137756A1
Автор: Mark T. Kingsley, Robin Brigmon
Принадлежит: SAVANNAH RIVER NUCLEAR SOLUTIONS LLC

An apparatus and process of using existing process water sources such as cooling towers, fountains, and waterfalls is provided in which the water sources are utilized as monitoring system for the detection of environmental agents which may be present in the environment. The process water is associated with structures and have an inherent filtering or absorbing capability available in the materials and therefore can be used as a rapid screening tool for quality and quantitative assessment of environmental agents.

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Номер записи: 77
07-06-2012 дата публикации

Antibodies and Methods of Use Thereof

Номер: US20120141373A1
Автор: Charles S. Craik, Eric L. Schneider
Принадлежит: UNIVERSITY OF CALIFORNIA

The disclosure relates to protease-binding agent specific for a protease. The agent may be an antibody capable of specifically binding and inhibiting a protease, such as a P1-Arg-specific protease. The disclosure also provides methods of producing, and compositions comprising the subject agent. Methods and kits related to the protease-binding agent find use in protection against, detection, diagnosing, treating cancer and infections due to pathogens containing active proteases.

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Номер записи: 78
07-06-2012 дата публикации

Use of pkc isozymes for diagnosis and treatment of neuroblastoma

Номер: US20120141498A1
Автор: Mildred E. Acevedo-Duncan, Rekha S. Patel
Принадлежит: UNIVERSITY OF SOUTH FLORIDA, US Department of Veterans Affairs VA

The present invention pertains to the use of PKC-epsilon (PKC-ε), PKC-delta (PKC-δ), PKC-eta, and/or PKC-theta as biomarker(s) for prediction and/or detection of neuroblastoma, as well as therapeutic targets for treatment of neuroblastoma.

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Номер записи: 79
07-06-2012 дата публикации

Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities

Номер: US20120142024A1
Автор: Josef Friedrich, Michael Pfeil
Принадлежит: Merz Pharma GmbH and Co KGaA

The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed (active) neurotoxin polypeptides in a solution comprising processed neurotoxin polypeptides and partially processed or unprocessed neurotoxin polypeptides. The present invention further relates to a device for determining the amount of neurotoxin polypeptides and a kit adapted to carry out the method of the present invention.

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Номер записи: 80
07-06-2012 дата публикации

Kits for assaying enzyme-mediated oxidative demethylation

Номер: US20120142038A1
Автор: Barbara Scheuer, Raymond Trievel, Russell Hart
Принадлежит: Arbor Assays LLC

Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative demethylation enzyme, a substrate for the oxidative demethylation enzyme and a formaldehyde detection reagent. Detection of fluorescence is indicative of formaldehyde generated by oxidative demethylation of the substrate by the enzyme, the fluorescence resulting from reaction of formaldehyde and the formaldehyde detection reagent.

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Номер записи: 81
07-06-2012 дата публикации

Methods and Kits for Quantitative Methyltransferase and Demethylase Measurements

Номер: US20120142040A1
Автор: Alan J. Tackett, Lauren P. Blair, Nathan L. Avaritt
Принадлежит: University of Arkansas

The invention provides methods and kits for characterizing the activity of a methyltransferase or demethylase. The method involves enzymatically methylating or demethylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically methylating the peptide substrate with methyl groups that differ in molecular weight from the enzymatically added or removed methyl groups. Typically, deuterated or 13 C formaldehyde is used to non-enzymatically methylate the substrate. The fully methylated substrate is then characterized by mass spectrometry to determine the ratio of enzymatically produced nonmethyl, monomethyl, and dimethyl residues on the peptide.

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Номер записи: 82
07-06-2012 дата публикации

Caspase-8 and skin disease

Номер: US20120144504A1
Автор: Andrei Kovalenko, David Wallach, Jin Chul Kim, Tae-Bong Kang
Принадлежит: Yeda Research and Development Co Ltd

The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.

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Номер записи: 83
14-06-2012 дата публикации

Antibodies That Bind Amyloid Oligomers

Номер: US20120148591A1
Автор: Rakez Kayed
Принадлежит: University of Texas System

Embodiments of the invention are directed to compositions and methods related to immunogenic compositions comprising the amino acid sequence of SEQ ID NO:1 and amyloid oligomer specific antibodies that specifically bind an oligomer comprising such a peptide.

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Номер записи: 84
14-06-2012 дата публикации

Methods of evaluating cells and cell cultures

Номер: US20120149013A1
Автор: Stephen J. Duguay, Stephen M. Rapko
Принадлежит: Genzyme Corp

Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some embodiments, the invention involves identifying cell culture composition or the identity of a cell based on expression level of a fibroblast marker. In other embodiments, the invention involves comparing expression levels of at least one chondrocyte marker and at least one fibroblast marker in a cell culture sample or in an individual cell. In illustrative embodiments, the chondrocyte marker is hyaluronan and proteoglycan link protein 1 (HAPLN1), and the fibroblast marker is microfibrillar associated protein 5 (MFAP5).

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Номер записи: 85
14-06-2012 дата публикации

Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein b ratios

Номер: US20120149596A1
Автор: Joseph L. Witztum, Sotirios Tsimikas
Принадлежит: UNIVERSITY OF CALIFORNIA

The present invention relates to the analysis of oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the present invention relates to methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability.

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Номер записи: 86
21-06-2012 дата публикации

Method and Pharmaceutical Composition for Use in the Treatment of Neurodegenerative Disorders

Номер: US20120156221A1
Автор: Alain Van Dorsselaer, Jose Alain Sahel, Ludivine Perrocheau, Thierry Leveillard
Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM

The invention relates to compounds which activate the BASIGIN signaling pathway, preferably agonists of BASIGIN, for the treatment of neurodegenerative disorders.

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Номер записи: 87
21-06-2012 дата публикации

Composition for diagnosis of liver metastasis of colorectal cancer and the use thereof

Номер: US20120156681A1
Автор: Ho-Kyung Chun, Woo Yong Lee, Yong Beom Cho
Принадлежит: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION

The present invention relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis of colorectal cancer, which comprises either a substance for measuring the mRNA level of CCL7 (Chemokine (C-C motif) ligand 7) gene or a substance for measuring the level of a protein which is encoded by the gene. According to the present invention, whether liver metastasis of colorectal cancer occurred can be diagnosed by measuring the mRNA expression level of the CCL7 gene or the expression level of the CCL7 protein, and the use of the composition comprising an inhibitor of CCL7 gene allows the treatment of colorectal cancer or the liver metastasis of colorectal cancer.

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Номер записи: 88
21-06-2012 дата публикации

Identification of Inhibitors of a Bacterial Stress Response

Номер: US20120157375A1
Автор: Kenneth Charles Keiler, Sarah Ellen Ades
Принадлежит: PENN STATE RESEARCH FOUNDATION

A system, a composition, a method and a kit for identifying anti-bacterial agents are provided. The invention described herein is useful in identifying inhibitors of any bacterial stress response. Moreover, the invention can be applied to any sRNA and its target, any transcription factor and its target, and any transcription factor/sRNA pair (i.e., a transcription factor that regulates a sRNA). In particular, the present invention provides a system, a composition, a method and a kit for the identification of cyclic peptides that block the σ E pathway in Escherichia coli.

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Номер записи: 89
28-06-2012 дата публикации

Test method on renal diseases

Номер: US20120164662A1
Автор: Akihiko Saito, Hiroyuki Kurosawa, Katsuhiko Asanuma, Masanori Hara, Shinya Ogasawara, Yasuhiko Tomino, Yoshiaki Hirayama
Принадлежит: Denka Seiken Co Ltd, Juntendo Educational Foundation, Niigata University NUC

Provided is a test method for the assessment of the necessity of renal biopsy in a subject to be tested, who is suspected of having a renal disease. Specifically provided are a test method for a renal disease, including using urinary podocalyxin and one or more additional markers in combination, and a test reagent for use in the test method and a test reagent kit for use in the test method. The present invention allows the discrimination of a poor prognosis group even for poor prognosis cases with no overt findings in a conventional test method, and thus allows the assessment of a renal disease, the assessment of the necessity of renal biopsy, prognostic prediction, and the like to be performed exactly.

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Номер записи: 90
28-06-2012 дата публикации

Interleukin-1 Alpha Antibodies and Methods of Use

Номер: US20120164665A1
Автор: John Simard
Принадлежит: Xbiotech Inc

Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.

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Номер записи: 91
28-06-2012 дата публикации

Inhibition of histone acetyltransferases by ctk7a and methods thereof

Номер: US20120165384A1
Автор: Gopinath Kadaganur Srinivasachar, Kempegowra Mantelingu, Mohammed Arif, Tapas Kumar Kundu
Принадлежит: Jawaharial Nehru Centre for Advanced Scientific Research

The present disclosure relates to a method for inhibiting histone acetyltransferases by derivative of curcumin, particularly CTK7A. The present disclosure also relates to identification of induction of autoacetylation of p300 and its inhibition by CTK7A. The disclosure also relates to induction of NPM1 and GAPDH overexpression and corresponding hyperacetylation of histone and methods thereof.

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Номер записи: 92
05-07-2012 дата публикации

Methods of treating, reducing and inhibiting the appearance of ageing in the skin

Номер: US20120171144A1
Автор: David James Granville, Rani Priya Gomez Cruz
Принадлежит: Individual

Methods of treating, reducing and inhibiting the appearance of ageing in the skin are provided. Also provided are uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subject comprising applying a granzyme B inhibitor to the skin of the subject. Also provided are methods of identifying a granzyme B inhibitors and agonists.

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Номер записи: 93
05-07-2012 дата публикации

Methods and materials for modulating deubiquitinases and ubiquitinated polypeptides

Номер: US20120171192A1
Автор: Jian Yuan, Zhenkun Lou
Принадлежит: Mayo Foundation for Medical Education and Research

This document relates to methods and materials involved in modulating deubiquitinases (e.g., USP10 polypeptides) and/or ubiquitinated polypeptides (e.g., tumor suppressor polypeptides or mutant versions of tumor suppressor polypeptides). For example, methods and materials for increasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for decreasing deubiquitinase (e.g., a USP10 polypeptide) expression or activity, methods and materials for stabilizing tumor suppressor polypeptides (e.g., wild-type p53 polypeptides), methods and materials for de-stabilizing mutant versions of tumor suppressor polypeptides (e.g., mutant p53 polypeptides), and methods and materials for reducing cancer cell proliferation, increasing cancer cell apoptosis, and/or treating cancer (e.g., cancers having reduced levels of wild-type p53 polypeptides or cancers having increased levels of mutant p53 polypeptides) are provided. This document also provides methods and materials for identifying agonists or antagonists of USP10 polypeptide mediated stabilization of p53 polypeptides.

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Номер записи: 94
05-07-2012 дата публикации

Use of pkc-zeta as a breast cancer tumorigenic biomarker as well as a target for treatment of breast cancer

Номер: US20120171219A1
Автор: Diondra D. Hill, Mildred Acevedo-Duncan
Принадлежит: UNIVERSITY OF SOUTH FLORIDA, US Department of Veterans Affairs VA

The present invention provides use of protein kinase C-zeta (PKC-ζ) as a diagnostic biomarker for breast cancer tumorigenesis. Also provided are uses of PKC-zeta inhibitors for inhibiting breast cancer tumorigenesis and for treatment of breast cancer.

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Номер записи: 95
05-07-2012 дата публикации

Further use of protein kinase n beta

Номер: US20120171220A1
Автор: Anke Klippel-Giese, Jörg Kaufmann
Принадлежит: SILENCE THERAPEUTICS AG

The present invention is related to use of protein kinase N beta or a fragment or derivative thereof as a downstream target of the PI 3-kinase pathway, preferably as a downstream drug target of the PI 3-kinase pathway.

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Номер записи: 96
05-07-2012 дата публикации

S. aureus allergen

Номер: US20120171238A1
Автор: Alexander M. Hirschi, Angelika Stöcklinger, Birgit Linhart, Elli Greisenegger, Josef Thalhamer, Kavita Reginald, Kerstin Westritschnig, Rudolf Valenta, Tamara Kopp, Thomas Werfel
Принадлежит: BIOMAY AG

The invention discloses the use of a protein with an amino acid sequence according to SEQ. ID. NO. 1 or a naturally occurring fragment or variant thereof for identifying infections with S. aureus in a human sample. More specifically, IgE molecules specific for SEQ. ID. NO. 1 are detected in the sample of the patient. Many atopic dermatitis patients have IgE specific for SEQ. ID. NO. 1.

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Номер записи: 97
05-07-2012 дата публикации

Fuidi herd management schema

Номер: US20120171689A1
Автор: Gilles Reza Georges Monif
Принадлежит: Individual

The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to Mycobacterium avium subspecies paratuberculosis (Map) and related genomic variants and upon the ability of two distinct Map ELISA tests to sequentially or in parallel determine prior and current Map infection and evidence of active mycobacterium replication. Interpretation of the test results are integrated into sequential directives designed to enhance productive retention of infected animals as well as identify animals not previously infected. The sequential utilization of the data guidelines is developed to minimize the adverse economic impact.

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Номер записи: 98
05-07-2012 дата публикации

Combination of spla2 activity and oxpl/apob cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event

Номер: US20120171705A1
Автор: Alain Tedgui, Joseph Witztum, Sotirios Tsimikas, Ziad Mallat
Принадлежит: Institut National de la Sante et de la Recherche Medicale INSERM, Universite Paris Diderot Paris 7, UNIVERSITY OF CALIFORNIA

The use of a combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event or for the monitoring of a cardiovascular disease.

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Номер записи: 99
05-07-2012 дата публикации

Therapeutic use for alpha1 proteinase inhibitor in hematopoiesis

Номер: US20120172286A1
Автор: Cynthia L. Bristow
Принадлежит: INSTITUTE FOR HUMAN GENETICS AND BIOCHEMISTRY

A previously unrecognized fundamental property of α 1 PI is to regulate the phenotypic composition of circulating and tissue-associated cells derived from hematopoietic stem cells. The present invention comprises screening for various unmodified and modified α 1 PI's which are useful in the treatment of abnormalities in the number of cells of myeloid or lymphoid lineage that are associated with HW-1 infection, microbial infection, leukemia, solid tumor cancers, atherosclerosis, autoimmunity, stem cell transplantation, organ transplantation, and other diseases affected by cells of the immune system. The interaction of α 1 PI with its receptors, HLE CS and LRP, influences the level of cells of different lineages. Genetic and proteolytic modification of α 1 PI is used to target these receptors to increase or decrease specific cell populations, as needed, in the various disease states.

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Номер записи: 100