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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 48469. Отображено 100.
05-01-2012 дата публикации

Electro-blotting Devices, Systems, and Kits and Methods for Their use

Номер: US20120000781A1
Автор: Adam Sartiel, Ilana Margalit, Itay Sela, Uri Yogev, Yuri Katz
Принадлежит: Lite Technologies Corp

The invention provides a dry electroblotting system for dry blotting gels, in which the system includes an electroblotting transfer stack that comprises an analysis gel and a blotting membrane, an anode, a body of anodic gel matrix juxtaposed with the anode between the anode and the transfer stack, a cathode, and a body of cathodic gel matrix juxtaposed with the cathode between the cathode and the transfer stack, in which the anodic gel matrix and the cathodic gel matrix each comprise an ion source for electrophoretic transfer. The dry electroblotting system does not use any liquid buffers that are added to the system just before electroblotting (such as when the transfer stack is being assembled). The anode, the cathode, or both can be separate from a power supply and provided as part of a disposable electrode assembly that also includes a body of gel matrix that includes ions for electrophoretic transfer.

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Номер записи: 1
10-12-2016 дата публикации

Устройство для обнаружения водорода

Номер: RU0000166907U1
Автор: Альберт Николаевич Именков, Аркадий Михайлович Оспенников, Вадим Аркадьевич Шутаев, Елена Александровна Гребенщикова, Наталья Дмитриевна Ильинская, Юрий Павлович Яковлев
Принадлежит: Федеральное государственное бюджетное учреждение науки Физико-технический институт им. А.Ф. Иоффе Российской академии наук

1. Устройство для обнаружения водорода, включающее источник видимого или ближнего ИК света, измеритель электрического тока, чувствительный элемент в виде пластины из монокристаллического фосфида индия InP n-типа проводимости, на центральную область первой поверхности которой последовательно нанесены слой анодного оксида индия и фосфора, слой палладия и первый омический электрод, на периферийную область первой поверхности нанесен диэлектрический слой из нитрида кремния SiN, на вторую поверхность пластины нанесен второй омический электрод, при этом источник видимого света оптически соединен со слоем палладия, а первый и второй омические электроды подключены к измерителю электрического тока или напряжения.2. Устройство по п. 1, отличающее тем, что пластина из монокристаллического InP легирована оловом до концентрации n основных носителей 10-10см.3. Устройство по п. 1, отличающее тем, что первый электрод имеет в плане крестообразную форму. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК G01N 27/407 (13) 166 907 U1 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ТИТУЛЬНЫЙ (21)(22) Заявка: ЛИСТ ОПИСАНИЯ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ 2016124848/28, 21.06.2016 (24) Дата начала отсчета срока действия патента: 21.06.2016 (45) Опубликовано: 10.12.2016 Бюл. № 34 (73) Патентообладатель(и): Федеральное государственное бюджетное учреждение науки Физико-технический институт им. А.Ф. Иоффе Российской академии наук (RU) легирована оловом до концентрации n основных носителей 1016-1017 см-3. 3. Устройство по п. 1, отличающее тем, что первый электрод имеет в плане крестообразную форму. R U 1 6 6 9 0 7 (57) Формула полезной модели 1. Устройство для обнаружения водорода, включающее источник видимого или ближнего ИК света, измеритель электрического тока, чувствительный элемент в виде пластины из монокристаллического фосфида индия InP n-типа проводимости, на центральную область первой поверхности которой последовательно нанесены слой анодного оксида индия и фосфора, слой палладия ...

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Номер записи: 2
07-03-2018 дата публикации

Картридж для определения показателя гемостаза в крови человека

Номер: RU0000177742U1
Автор: Андрей Владимирович Тронин, Татьяна Александровна Середина
Принадлежит: Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН)

Полезная модель относится к медицинской и биологической технике, а именно к вспомогательному оборудованию для исследования показателей гемостаза.Техническими результатами полезной модели является возможность быстрого и высокоточного исследования крови на показатель гемостаза.Технические результаты достигаются тем, что картридж для определения показателя гемостаза в крови человека содержит корпус с размещенными в нем входным портом для приема исследуемого образца крови и соединенными с портом через микрофлюидную систему каналов тремя измерительными камерами, в каждой из которых расположена пара электродов для измерения импеданса в исследуемом образце и индуктор, инициирующий при смешивании с исследуемым образцом его коагуляцию, при этом все камеры имеют одинаковые размеры, тип и количество индуктора в каждой из них одинаковое, а корпус картриджа содержит дополнительный армирующий слой.Заявляемый картридж для определения показателя гемостаза в крови человека технологичен в изготовлении и позволяет оперативно и с высокой точностью проводить исследования. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 177 742 U1 (51) МПК G01N 33/49 (2006.01) G01N 27/403 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 33/49 (2006.01); G01N 27/403 (2006.01) (21)(22) Заявка: 2017121008, 15.06.2017 (24) Дата начала отсчета срока действия патента: 07.03.2018 Приоритет(ы): (22) Дата подачи заявки: 15.06.2017 (45) Опубликовано: 07.03.2018 Бюл. № 7 U1, 27.08.2009. US 20080297169 A1, 04.12.2008. US 8563325 B1, 22.10.2013. (54) Картридж для определения показателя гемостаза в крови человека (57) Реферат: Полезная модель относится к медицинской и которых расположена пара электродов для биологической технике, а именно к измерения импеданса в исследуемом образце и вспомогательному оборудованию для индуктор, инициирующий при смешивании с исследования показателей гемостаза. исследуемым образцом его коагуляцию, при этом Техническими ...

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Номер записи: 3
29-05-2019 дата публикации

Сенсор для измерения концентрации кислорода и водорода в инертных, защитных и окислительных газовых смесях

Номер: RU0000189631U1
Автор: Александр Николаевич Волков, Анатолий Сергеевич Калякин, Анна Владимировна Касьянова, Кирилл Евгеньевич Волков
Принадлежит: Федеральное государственное бюджетное учреждение науки Институт высокотемпературной электрохимии Уральского отделения Российской академии наук

Использование: для измерения концентрации кислорода, водорода в инертных и защитных газовых смесях. Сущность полезной модели заключается в том, что сенсор состоит из протонной и кислородной электрохимических ячеек, каждая из которых имеет измерительный и эталонный электроды, при этом водородная ячейка представляет собой два, склеенных между собой диска из протонопроводящего твердого электролита, один из дисков имеет полость, соединенную с капилляром, снаружи этого диска и внутри полости размещены электроды, другой диск газоплотным стеклом приклеен к твердоэлектролитной пробирке, являющейся кислородной электрохимической ячейкой, внутри пробирки расположен эталонный электрод из смеси металл-металлоксид, а снаружи – измерительный электрод. Технический результат: обеспечение возможности одновременного измерения содержания кислорода и водорода в газовых смесях без использования эталонного газа. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 189 631 U1 (51) МПК G01N 27/41 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ПОЛЕЗНОЙ МОДЕЛИ К ПАТЕНТУ (52) СПК G01N 27/41 (2019.02) (21)(22) Заявка: 2019107530, 18.03.2019 (24) Дата начала отсчета срока действия патента: Дата регистрации: 29.05.2019 (45) Опубликовано: 29.05.2019 Бюл. № 16 Адрес для переписки: 620990, Свердловская обл., г. Екатеринбург, ул. Академическая, 20, ИВТЭ УРО РАН (73) Патентообладатель(и): Федеральное государственное бюджетное учреждение науки Институт высокотемпературной электрохимии Уральского отделения Российской академии наук (RU) (56) Список документов, цитированных в отчете о поиске: RU 2483298 C1, 27.05.2013. RU U 1 1 8 9 6 3 1 R U (54) Сенсор для измерения концентрации кислорода и водорода в инертных, защитных и окислительных газовых смесях (57) Реферат: Использование: для измерения концентрации и внутри полости размещены электроды, другой кислорода, водорода в инертных и защитных диск газоплотным стеклом приклеен к газовых смесях. Сущность полезной модели твердоэлектролитной ...

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Номер записи: 4
26-01-2012 дата публикации

Array configuration and readout scheme

Номер: US20120022795A1
Автор: Jeremy JORDAN, Kim Johnson, Mark Milgrew, Peter Levine
Принадлежит: Life Technologies Corp

The described embodiments may provide a chemical detection circuit that may comprise a plurality of first output circuits at a first side and a plurality of second output circuits at a second side of the chemical detection circuit. The chemical detection circuit may further comprise a plurality of tiles of pixels each placed between respective pairs of first and second output circuits. Each tile may include four quadrants of pixels. Each quadrant may have columns with designated first columns interleaved with second columns. Each first column may be coupled to a respective first output circuit in first and second quadrants, and to a respective second output circuit in third and fourth quadrants. Each second column may be coupled to a respective second output circuit in first and second quadrants, and to a respective first output circuit in third and fourth quadrants.

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Номер записи: 5
02-02-2012 дата публикации

Biosensor system and method for measuring concentration of analyte

Номер: US20120028282A1
Автор: Motonori Uchiyama
Принадлежит: Individual

A biosensor system can comprise a sensor chip and a measurement device. The sensor chip comprises a capillary and electrodes disposed within the capillary. The height of the capillary is set to be less than the maximum value of the sum of the diffusion distance of an electron-transfer mediator and the diffusion distance of an analyte at the upper limit of the measurement guaranteed temperature of the biosensor system. The measurement device applies an open circuit voltage, a voltage that is lower than during concentration measurement, or the like to the electrodes of the sensor chip.

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Номер записи: 6
09-02-2012 дата публикации

Carboxylic polybenzimidazole

Номер: US20120035333A1
Автор: Hsiao-Chien Chen, Lee-Yih Wang, Mu-Yi Hua, Rung-Ywan Tsai
Принадлежит: Chang Gung University CGU

A carboxylic polybenzimidazole includes at least one of the following functional group of formula (I): wherein G is a group containing a carboxylic acid end group or a carboxylated end group.

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Номер записи: 7
23-02-2012 дата публикации

Measurement method utilizing internal standard substance

Номер: US20120043207A1
Автор: Naoyuki Yamamoto, Tatsuo Kurosawa
Принадлежит: Wako Pure Chemical Industries Ltd

A subject of the present invention is to provide a measurement method using an internal standard substance in an electrophoresis where an analyte is a protein or a compound. The present invention relates to a measurement method for an analyte by an electrophoresis, characterized in that a peak of the analyte is identified by using as an internal standard substance (1) a combination of a compound I having 3 or more anion groups in a molecule and a compound II where 1 to 3 groups of the anion groups of said compound I have been substituted by cation groups, or (2) a combination of a compound III having 3 or more cation groups in a molecule and a compound IV where 1 to 3 groups of the cation groups of said compound III have been substituted by cation groups.

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Номер записи: 8
08-03-2012 дата публикации

Gas Sensor Assembly with Interior Heat Dissipation, Sealing, and Support Plug

Номер: US20120055790A1
Автор: Danny L. Koester, Robert L. Newman, Terry R. Bloom
Принадлежит: CTS Corp

A gas sensor assembly including a substrate located in a housing. The substrate includes a high temperature gas sensor end and a lower temperature electronics end. A heat transfer, sealing, and support plug is mounted in the housing to the substrate. The plug seals the sensor end from the electronics end and transfers the heat generated at the high temperature sensor end successively through the substrate, the thermally conductive plug, the housing, and into the outside air. In one embodiment, the housing includes a collar which surrounds a portion of the substrate and is coupled to and supported on one end of the plug and a jacket which surrounds the electronics end of the substrate and includes a neck coupled to and supported on an opposite end of the plug.

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Номер записи: 9
08-03-2012 дата публикации

Msp nanopores and related methods

Номер: US20120055792A1
Автор: Jens H. Gundlach, Mark A. Troll, Michael Niederweis, Mikhail PAVLENOK, Thomas Z. BUTLER
Принадлежит: UAB RESEARCH FOUNDATION, UNIVERSITY OF WASHINGTON

Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

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Номер записи: 10
08-03-2012 дата публикации

Modified graphene structures and methods of manufacture thereof

Номер: US20120058350A1
Автор: Aidan Quinn, Bartholomäus Szafranek, Brenda Long, Mary Manning
Принадлежит: Individual

The present invention is directed to a modified graphene structure comprising at least one graphene sheet ( 1 ) and a self-assembled monolayer ( 2 ) of functional organic molecules ( 3 ) non-covalently bonded to the top and/or bottom basal planes of the graphene sheet and methods of manufacture thereof. The present invention is also directed to devices comprising the modified graphene structures, including but not limited to field-effect devices and biosensors, and to methods using the modified graphene structures.

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Номер записи: 11
15-03-2012 дата публикации

Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays

Номер: US20120065093A1
Автор: Jonathan Rothberg, Wolfgang Hinz
Принадлежит: Life Technologies Corp

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes.

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Номер записи: 12
22-03-2012 дата публикации

Electrochemical sensors

Номер: US20120067724A1
Автор: Carolyn R. Kahn, Elicia Wong, Vern Norviel
Принадлежит: Sensor Innovations Inc

Described herein are substrates, sensors and systems related to measuring the concentration of an analyte such as hydrogen ion in a sample. Redox active moieties whose reduction and/or oxidation potentials are sensitive to the presence of an analyte are immobilized onto a surface of an electrode. Immobilized redox active moieties whose reduction and/or oxidation potential are insensitive to the analyte can be used for reference. Voltammetric measurements made using such modified surfaces can accurately determine the presence and/or concentrations of analytes in a sample of interest. The electrochemical sensors of the invention are robust and can be made so as not to require calibration or recalibration.

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Номер записи: 13
22-03-2012 дата публикации

Microanalysis methods and systems using field effect transistor

Номер: US20120070910A1
Автор: Chan Woo Park, Chang-geun Ahn, Chil Seong Ah, Gun Yong Sung, Jong-Heon Yang
Принадлежит: Electronics and Telecommunications Research Institute ETRI

Provided is a microanalysis method and system using a Field Effect Transistor (FET). The microanalysis method includes a channel region having a receptor molecule fixed; forming a nano-particle conjugate in the channel region by supplying a sample for test and the nano-particle conjugate to the FET; growing a probe material on the channel region; and measuring a current flowing through the channel region, wherein the receptor molecule is a material that is selectively bonded to a target molecule in the sample for test.

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Номер записи: 14
29-03-2012 дата публикации

Air-fuel ratio sensor

Номер: US20120073356A1
Автор: Haruki Kondo, Hiroki NISHIJIMA, Takechi Hirabayashi, Yasufumi Suzuki
Принадлежит: Denso Corp, Toyota Motor Corp

An air-fuel ratio sensor includes a solid electrolyte layer, a measuring electrode laminated on a first face of the solid electrolyte layer, a reference electrode laminated on a second face of the solid electrolyte layer which is different from the first face thereof, such that the reference electrode and the measuring electrode are opposed to each other with the solid electrolyte layer interposed therebetween, a porous diffusion resistance layer that permits gas to pass therethrough and covers the measuring electrode, and a catalyst layer including a catalyst metal and a base material on which the catalyst metal is supported. The catalyst layer permits gas to pass therethrough and covers the porous diffusion resistance layer. The catalyst metal is a platinum-palladium-rhodium alloy, and contains 2 to 9 mass % of rhodium when the overall amount of the catalyst layer is represented as 100 mass %.

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Номер записи: 15
29-03-2012 дата публикации

Apparatus for high-throughput suspension measurements

Номер: US20120073972A1
Автор: Fraser Mcneil Watson
Принадлежит: Malvern Instruments Ltd

A high-throughput optical suspension characterization instrument is disclosed, which can include hydraulically separate and at least partially transparent sample containers. A selection mechanism is operative to selectively direct light from a light source ( 12 ) through different ones of the sample containers along an optical axis, and an off-axis scattering detector ( 38,24 ) is responsive to scattered light from the light source after it has interacted with a sample. Phase analysis light scattering is used to determine the electrophoretic mobility and zeta potential of samples. A second instrument is disclosed, wherein all sample containers are illuminated simultaneously. Transmitted light is collected by a camera. The electrophoretic mobility and hydrodynamic size of the samples may be determined.

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Номер записи: 16
19-04-2012 дата публикации

Device for detecting an analyte

Номер: US20120090995A1
Автор: Anton Seidl, Eric Lee, Gregory G Wildgoose, Joseph A. Duimstra, Joseph I. Keto, Lee Leonard, Mark Micklatcher, Victor Simonyi
Принадлежит: SENOVA SYSTEMS Inc

Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.

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Номер записи: 17
26-04-2012 дата публикации

Biosensing device

Номер: US20120101737A1
Автор: Meng Yi Lin
Принадлежит: Health and Life Co Ltd

The present invention provides a biosensing device, comprising an input unit, an analysis unit, a process unit, and a set unit for storing resulting data values as the basis for calibrating the biosensing device, to set up the calibration parameters of a strip of the biosensing device.

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Номер записи: 18
03-05-2012 дата публикации

Liquid sample measurement method and apparatus

Номер: US20120103806A1
Автор: Teppei Shinno, Yoshifumi Takahara
Принадлежит: Individual

A liquid sample measurement apparatus of the present invention is provided with a timer ( 122 ) for measuring the time from when a biosensor ( 30 ) is attached to a liquid sample measurement device ( 110 a ) which measures the concentration of a specific component in a liquid sample that is applied to the biosensor ( 30 ) to when the liquid sample is applied to the biosensor ( 30 ), and correction based on the time measured by the timer ( 122 ) is performed to the measurement result of the concentration of the specific component in the liquid sample that is applied to the biosensor ( 30 ). Thereby, the measurement precision can be enhanced with utilizing the correction algorithm in which the ambient temperature and the temperature of the biosensor itself are considered.

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Номер записи: 19
03-05-2012 дата публикации

Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus

Номер: US20120103816A1
Автор: Norberto A. Guzman
Принадлежит: Individual

The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as a modular, multi-task immunoaffinity device secured to a peripheral box and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. In one embodiment, two devices are coupled in-tandem to perform separately and sequentially microreactions and concentrations of proteins. In this embodiment, biological samples containing proteins can be subjected to proteolytic processing in the first device, and the resulting peptides subjected to selective purification and concentration in the second device.

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Номер записи: 20
17-05-2012 дата публикации

Gas sensor

Номер: US20120118039A1
Автор: Masao Tsuzuki, Takaya Yoshikawa
Принадлежит: NGK Spark Plug Co Ltd

A gas sensor including a detecting element; and a protector having a tube portion surrounding the detecting portion, and a bottom portion the protector having a first opening disposed at the tube portion and a second opening at the bottom portion. The bottom portion includes first and second bottom wall portions, the second bottom wall portion protrudes toward the leading end side, and at least a part of the inner face thereof is located at the leading end side with respect to the outer face of the first bottom wall portion. The second opening is provided on a side opposite the inner space of the tube portion in a communication passage formed by the inner face of the second bottom wall portion, and an opening area of the second opening is larger than an area of the largest imaginary circle that can be placed inside the first opening.

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Номер записи: 21
07-06-2012 дата публикации

Ion sensitive sensor with multilayer construction in the sensor region

Номер: US20120139011A1
Автор: Hendrik Zeun
Принадлежит: Endress and Hauser Conducta Gesellschaft fuer Mess und Regeltechnik mbH and Co KG

An ion sensitive sensor having an EIS structure, including: a semiconductor substrate, on which a layer of a substrate oxides is produced; an adapting or matching layer, which is prepared on the substrate oxide; a chemically stable, intermediate insulator, which is deposited on the adapting or matching layer; and an ion sensitive, sensor layer, which is applied on the intermediate insulator. The adapting or matching layer differs from the intermediate insulator and the substrate oxide in its chemical composition and/or structure. The adapting or matching layer and the ion sensitive, sensor layer each have an electrical conductivity greater than that of the intermediate insulator. There is an electrically conductive connection between the adapting or matching layer and the ion sensitive, sensor layer.

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Номер записи: 22
07-06-2012 дата публикации

Methods for ionophorically screening pore forming bacterial protein toxins and receptors

Номер: US20120142044A1
Автор: John Cuppoletti
Принадлежит: Individual

One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors for insect toxicity. The method includes: a) forming a membrane comprising a lipid and an insect receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c) measuring ion flow through the membrane. Also provided are a method and kit for determining the amount of live pore forming bacterial toxin protein in a sample.

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Номер записи: 23
14-06-2012 дата публикации

Methods and devices of separating molecular analytes

Номер: US20120145548A1
Автор: Elad Brod, Uri Sivan
Принадлежит: Technion Research and Development Foundation Ltd

A method of separating a mixture of a plurality of molecular analytes having different isoelectric points (pIs). The method comprises placing a solution containing a mixture of a plurality of molecular analytes in a separation volume, generating a pH profile having a plurality of pH zones across an axis of the separation volume, and adjusting a profile of the pH profile to induce a migration of a first molecular analyte along the axis apart from a second molecular analyte. The first and second molecular analytes having different pIs.

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Номер записи: 24
21-06-2012 дата публикации

Method of making an electrically conductive structure, method of making a gas sensor, gas sensor obtained with the method and use of the gas sensor for sensing a gas

Номер: US20120151997A1
Автор: Jinesh Kochupurackal, Mercedes Crego Calama, Sywert Brongersma
Принадлежит: STICHTING IMEC NEDERLAND

A method of making an electrically conductive structure in a surface portion of a dielectric material is disclosed. In one aspect, the method includes creating vacancies at at least part of an exposed surface of the dielectric material by removing atoms from a plurality of molecules of the dielectric material.

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Номер записи: 25
21-06-2012 дата публикации

Laser doppler electrophoresis using a diffusion barrier

Номер: US20120152745A1
Автор: Jason Cecil William Corbett, Kevin Mattison, Malcolm Connah
Принадлежит: Malvern Instruments Ltd

In one general aspect, an electrophoretic measurement method is disclosed that includes providing a vessel that holds a dispersant, providing a first electrode immersed in the dispersant, and providing a second electrode immersed in the dispersant. A sample is placed at a location within the dispersant between the first and second electrodes with the sample being separated from the electrodes, an alternating electric field is applied across the electrodes, and the sample is illuminated with temporally coherent light. A frequency shift is detected in light from the step of illuminating that has interacted with the sample during the step of applying an alternating electric field, and a property of the sample is derived based on results of the step of detecting.

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Номер записи: 26
28-06-2012 дата публикации

Apparatus for analyzing gas information

Номер: US20120160008A1
Автор: Seiji Maeda
Принадлежит: NGK Spark Plug Co Ltd

A gas information estimation apparatus ( 100 ) is connected to a gas sensor element for detecting the concentration of gas flowing through an internal combustion engine ( 11 ), and estimates gas information other than the concentration. The apparatus includes gas sensor element provisional temperature calculation means ( 51 ) for calculating a provisional temperature of the gas sensor element using a predetermined simulation model, and inputting a reference value to the model as the parameter value; gas sensor element actual temperature measurement means ( 53 ), ( 54 ); gas information calculation means ( 55 ) for calculating the true value of the parameter value which can be input to the model in place of the reference value such that the provisional temperature of the gas sensor element approaches the actual temperature; and gas information obtaining means ( 57 ) for obtaining an estimative value of the gas information from the true value.

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Номер записи: 27
28-06-2012 дата публикации

Dry compositions and methods for gel electrophoresis

Номер: US20120160684A1
Автор: Mark N. Brolaski, Suzanne Kennedy, Vince Moroney
Принадлежит: MO Bio Laboratories Inc

The invention provides dry compositions for preparing and loading a sample on a gel for electrophoretic separation. The dry compositions preferably include a tracking dye and a sedimenting agent selected from a five-carbon polyol (e.g., ribitol, arabitol, or xylitol), iso-erythritol, maltitol, and saccharine. Methods for making and using, as well as kits comprising the disclosed compositions, are also provided.

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Номер записи: 28
28-06-2012 дата публикации

Chemical sensing and/or measuring devices and methods

Номер: US20120161207A1
Автор: Andrew P. Homyk, Axel Scherer, Michael D. Henry, Sameer WALAVALKAR
Принадлежит: California Institute of Technology CalTech

Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in a fluid are described. Devices may comprise a metal-oxide-semiconductor field-effect transistor (MOSFET) structure.

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Номер записи: 29
05-07-2012 дата публикации

Two-Transistor Pixel Array

Номер: US20120168784A1
Автор: Keith FIFE, Kim Johnson, Mark Milgrew
Принадлежит: Life Technologies Corp

A two-transistor (2T) pixel comprises a chemically-sensitive transistor (ChemFET) and a selection device which is a non-chemically sensitive transistor. A plurality of the 2T pixels may form an array, having a number of rows and a number of columns. The ChemFET can be configured in a source follower or common source readout mode. Both the ChemFET and the non-chemically sensitive transistor can be NMOS or PMOS device.

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Номер записи: 30
12-07-2012 дата публикации

Ion selective electrode cartridge

Номер: US20120175254A1
Автор: Teruyuki Kobayashi, Tsuyoshi Uchida
Принадлежит: Hitachi Chemical Co Ltd

Ion concentration measurement requires a calibration before the start of the measurement, and thus the start of the measurement is delayed for the calibration period. Hence, an ion selective electrode cartridge including an ion selective electrode for measuring the concentration of particular ions dissolved in a test solution is provided with a storage means storing therein an electrode slope value specific to the ion selective electrode.

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Номер записи: 31
19-07-2012 дата публикации

Filler for analyzing capillary electrophoresis-based single strand conformation polymorphism, and method for using the filler for analyzing capillary electrophoresis-based single strand conformation polymorphism

Номер: US20120181175A1
Автор: Gi Won Shin, Gyoo Yeol Jung, Hee Sung Hwang, Hyun Kee Kim
Принадлежит: BIO CO Ltd

The present invention relates to filler for analyzing capillary electrophoresis-based single strand conformation polymorphism, and to a method for using the filler for analyzing capillary electrophoresis-based single strand conformation polymorphism, and more particularly, to filler for analyzing capillary electrophoresis-based single strand conformation polymorphism, the filler containing a polymer micelle formed by dispersing a sandwich-block copolymer comprising (Hydrophilic group)-(Hydrophobic group)-(Hydrophilic group) in an aqueous medium, and to a method for using the filler for analyzing capillary electrophoresis-based single strand conformation polymorphism.

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Номер записи: 32
19-07-2012 дата публикации

Methods for the detection of biologically relevant molecules and their interaction characteristics

Номер: US20120181176A1
Автор: Christopher Gordon Atwood
Принадлежит: Christopher Gordon Atwood

Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings, and measuring the electric current through the holes or the fluorescence near the hole openings. The electric current or fluorescence will change as the molecules diffuse out of the holes, providing a measure of the diffusion rate and thereby detecting the presence and characteristics of the molecules. For molecules that interact, the diffusion rate will be slower than for molecules that do not interact, yielding a determination of the molecular interaction. Capping the population of holes and inserting into a mass spectrometer allows identification of the molecules.

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Номер записи: 33
19-07-2012 дата публикации

Multiple laminar flow-based particle and cellular separation with laser steering

Номер: US20120183947A1
Автор: Amy Anderson, Daniel Mueth, Jessica Shireman, Joseph Plewa, Lewis Gruber, Neil Harris Rosenbaum
Принадлежит: Arryx Inc

The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

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Номер записи: 34
19-07-2012 дата публикации

Apparatus and Method for Detecting and/or Quantifying Compounds of Interest Present in Gaseous Form or Dissolved In A Solvent

Номер: US20120184041A1
Автор: Alexandre Carella, Jean-Pierre Simonato
Принадлежит: Commissariat a lEnergie Atomique et aux Energies Alternatives CEA

The invention relates to an apparatus and method for detecting and/or quantifying compounds of interest present in gaseous form or dissolved in a solvent. The apparatus according to the invention includes an electrical device including two electrodes, and a device for measuring the variation in charges between the two electrodes of the electrical device. The electrical device includes a layer made of an insulating dielectric material onto which a layer of receptor molecules is grafted, and finally, a layer of semiconductor material is deposited onto the receptor molecule layer. The invention can be used in the field of detecting and/or quantifying compounds of interest present, in particular, in a gas or in a solution.

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Номер записи: 35
26-07-2012 дата публикации

System for detecting electrical properties of a molecular complex

Номер: US20120187963A1
Автор: Roger Chen
Принадлежит: Genia Technologies Inc

A system for detecting electrical properties of a molecular complex is disclosed. The system includes an electrode electrically coupled to a molecular complex that outputs an electrical signal affected by an electrical property of the molecular complex, wherein the effect of the electrical property of the molecular complex on the electrical signal is characterized by an expected bandwidth. The system further includes an integrating amplifier circuit configured to receive the electrical signal from the electrode. The integrating amplifier circuit is further configured to selectively amplify and integrate a portion of the electrical signal over time within a predetermined bandwidth, wherein the predetermined bandwidth is selected at least in part based on the expected bandwidth.

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Номер записи: 36
02-08-2012 дата публикации

Contact member for gas sensor, gas sensor, constraint member, connecting method of sensor element and contact member of gas sensor, manufacturing method of gas sensor

Номер: US20120192653A1
Автор: Hirohito Kiyota, Koichi Masuda, Nobukazu Ikoma
Принадлежит: NGK Insulators Ltd

To provide a gas sensor which can stably carry out a securement of an electric continuity between a sensor element and a contact member. A contact member in which an electric connection to a sensor element is obtained by pinching and fixing the sensor element in an inserting port formed by a pair of housing members includes a constraint member which is provided in an outer periphery of a pair of housing members. The constraint member constrains a displacement of a pair of housing members within a predetermined range before the sensor element is pinched and fixed by a pair of housing members, and exists in a state of being pinched between the annular member and a pair of housing member without generating any reaction force with respect to the external force, after the sensor element is pinched and fixed.

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Номер записи: 37
02-08-2012 дата публикации

Apparatus and methods for microfluidic applications

Номер: US20120195809A1
Автор: Douglas Roy, Joel Fearnley, Peter Ghazal, Stuart Polwart
Принадлежит: AGILENT TECHNOLOGIES INC

Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.

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Номер записи: 38
02-08-2012 дата публикации

Methods and devices for detecting unsaturated compounds

Номер: US20120196379A1
Автор: Abdul-Majeed Azad, Desikan Sundararajan, Robert Howard Kinner
Принадлежит: Individual

A method for detecting an unsaturated compound, the method comprising monitoring change in electrical properties of a substance that reacts or interacts with unsaturated compounds.

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Номер записи: 39
16-08-2012 дата публикации

Control of operation conditions within fluidic systems

Номер: US20120204964A1
Автор: Donald J. Morrissey, JR., J. Wallace Parce, Yung-Mae M. Yao
Принадлежит: Caliper Life Sciences Inc

The invention provides methods of controlling environmental conditions within a fluidic system, where such environmental conditions can affect the operation of the system in its desired function, and fluidic channels, devices, and systems that are used in practicing these methods. Such methods are generally directed to environmental control fluids, the movement of such fluids through these systems, and the interaction of these fluids with other components of the system, e.g., other fluids or solid components of the system.

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Номер записи: 40
30-08-2012 дата публикации

Graphene-encapsulated nanoparticle-based biosensor for the selective detection of biomarkers

Номер: US20120220053A1
Автор: Aniruddh Solanki, Ki-Bum Lee, Sung Myung
Принадлежит: Rutgers State University of New Jersey

A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers.

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Номер записи: 41
06-09-2012 дата публикации

Nanopore Device for Reversible Ion and Molecule Sensing or Migration

Номер: US20120222958A1
Автор: Bakthan Singaram, Boaz VILOZNY, Nader Pourmand, Paolo ACTIS, R. Adam Seger
Принадлежит: UNIVERSITY OF CALIFORNIA

Disclosed are methods and devices for detection of ion migration and binding, utilizing a nanopipette adapted for use in an electrochemical sensing circuit. The nanopipette may be functionalized on its interior bore with metal chelators for binding and sensing metal ions or other specific binding molecules such as boronic acid for binding and sensing glucose. Such a functionalized nanopipette is comprised in an electrical sensor that detects when the nanopipette selectively and reversibly binds ions or small molecules. Also disclosed is a nanoreactor, comprising a nanopipette, for controlling precipitation in aqueous solutions by voltage-directed ion migration, wherein ions may be directed out of the interior bore by a repulsing charge in the bore.

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Номер записи: 42
13-09-2012 дата публикации

Array Column Integrator

Номер: US20120228136A1
Автор: Peter Levine
Принадлежит: Life Technologies Corp

Circuits are described for reading a chemically-sensitive field-effect transistor (chemFET) with an improved signal-to-noise ratio. In one embodiment, a device is described that includes a chemFET including a first terminal and a second terminal, and a floating gate coupled to a passivation layer. An integrator circuit is coupled to the second source/drain terminal of the chemFET via a data line. The integrator circuit applies a bias voltage to the data line during a read interval, thereby inducing a current through the chemFET based on a threshold voltage of the chemFET. The integrator circuit then generates an output signal proportional to an integral of the induced current through the chemFET during the read interval.

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Номер записи: 43
13-09-2012 дата публикации

Protection and surface modification of carbon nanostructures

Номер: US20120228157A1
Автор: Chunhong Li, David J. Ruggieri, Piu Francis Man
Принадлежит: Nanoselect Inc

Nanostructures comprising carbon and metal catalyst that are formed on a substrate, such as a silicon substrate, are contacted with a composition that, among other useful modifications, protects the nano structures and renders them stable in the presence of oxidizing agents in an aqueous environment. The protected nano structures are rendered stable over an extended period of time and thereby remain useful during such period as components of an electrode, for example, for detecting electrochemical species such as free chlorine, total chlorine, or both in water.

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Номер записи: 44
20-09-2012 дата публикации

Precast gel for electrophoresis, method for producing the same, and use of the same

Номер: US20120234669A1
Автор: Kazuhisa Suzuki, Mika Suzuki, Yukiko Minegishi
Принадлежит: Hymo Corp

This invention relates to a precast gel for electrophoresis comprising a support filled with an aqueous gel prepared by polymerizing an aqueous solution comprising a radically polymerizable monomer, a crosslinkable monomer, a buffer, a redox initiator comprising an oxidizer/reducer, and a photo sensitizer and having a pH level of 6.0 to 7.5 via light application. The slab gel for electrophoresis of the present invention can produce a precast gel for electrophoresis within a shorter period of time and in an easier manner than is possible with conventional techniques. Accordingly, the present invention enables production of a high-quality precast gel for electrophoresis in terms of productivity, cost, and quality, and the industrial applicability thereof is remarkable.

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Номер записи: 45
20-09-2012 дата публикации

Biosensor, biosensor chip and biosensor device

Номер: US20120234677A1
Автор: Hiroya Ueno, Junji Nakatsuka
Принадлежит: Individual

A biosensor includes a working electrode 101 , a counter electrode 102 opposing the working electrode 101 , a working electrode terminal 103 and a working electrode reference terminal 10 connected to the working electrode 101 by wires, and a counter electrode terminal 104 connected to the counter electrode 102 by a wire. By employing a structure with at least three electrodes, it is possible to assay a target substance without being influenced by the line resistance on the working electrode side.

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Номер записи: 46
20-09-2012 дата публикации

Nanodevices for generating power from molecules and batteryless sensing

Номер: US20120237853A1
Автор: Alex V. Hamza, Xianying Wang, Yinmin Wang
Принадлежит: Lawrence Livermore National Security LLC

A nanoconverter or nanosensor is disclosed capable of directly generating electricity through physisorption interactions with molecules that are dipole containing organic species in a molecule interaction zone. High surface-to-volume ratio semiconductor nanowires or nanotubes (such as ZnO, silicon, carbon, etc.) are grown either aligned or randomly-aligned on a substrate. Epoxy or other nonconductive polymers are used to seal portions of the nanowires or nanotubes to create molecule noninteraction zones. By correlating certain molecule species to voltages generated, a nanosensor may quickly identify which species is detected. Nanoconverters in a series parallel arrangement may be constructed in planar, stacked, or rolled arrays to supply power to nano- and micro-devices without use of external batteries. In some cases breath, from human or other life forms, contain sufficient molecules to power a nanoconverter. A membrane permeable to certain molecules around the molecule interaction zone increases specific molecule nanosensor selectivity response.

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Номер записи: 47
04-10-2012 дата публикации

Method for analyzing rna

Номер: US20120253687A1
Автор: Hitoshi Nobumasa, Osamu Nomura, Toshihiko Kuroda
Принадлежит: TORAY INDUSTRIES INC

A method of analyzing RNA extracted from a tissue or cell(s) fixed with a fixative, said method comprising a determining step of whether said RNA satisfies: B/A≦1 wherein A represents the weight ratio (%) of RNA within the range of 1000 to 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis; and B represents the weight ratio (%) of RNA within the range of more than 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis.

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Номер записи: 48
11-10-2012 дата публикации

Method and device for determining the concentration of oxidizing agent(s) in an aqueous solution

Номер: US20120255876A1
Автор: Michael Schelch, Robert Hermann, Wolfgang Staber, Wolfgang Wesner
Принадлежит: Pro Aqua Diamantelektroden Produktion GmbH and Co KG

In a method and a device for determining the concentration of one or more oxidizing agents in an aqueous solution flowing in a main stream, a partial flow of the aqueous solution is diverted to a bypass, wherein the difference between the potential of the aqueous solution before and after at least partial and/or selective breakdown of any oxidizing agents is measured. The bypass is for diverting and returning the partial flow of the aqueous solution, and has at least one elimination unit through which the aqueous solution flows for at least partial and/or selective breakdown of the oxidizing agent(s), and two measuring electrodes for determining the difference between the potentials of the aqueous solution before and after it passes through the elimination unit.

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Номер записи: 49
18-10-2012 дата публикации

Dna sequencing employing nanomaterials

Номер: US20120264617A1
Автор: John W. Pettit
Принадлежит: Individual

Charge transfer doped nanomaterials such as hydrogen terminated diamond, nanotubes, nanowires or similar nanostructures are used to create a highly sensitive pH sensor, or ion sensitive sensor to directly detect the addition of a newly incorporated nucleotide when performing DNA sequencing by synthesis. A single highly integrated chip can be made to sequence many strands of DNA in a massively parallel fashion in a short amount of time with a direct electronic readout that will bring the cost, size, power consumption of sequencing DNA to very attractive and useful levels.

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Номер записи: 50
25-10-2012 дата публикации

Device and method for diagnosing an exhaust gas sensor

Номер: US20120266647A1
Автор: Ekkehart-Peter Wagner, Frank Friedhof, Stefan Barnikow
Принадлежит: Continental Automotive GmbH

A device for diagnosing an exhaust gas sensor, in particular a linear oxygen probe, for an internal combustion engine. A diagnostic unit is configured to control a first and a second current source in a coordinated manner in order to generate a first and a second current. Each of the currents has a predefined polarity sign, and is designed to determine the first and/or second and/or third voltages applied at a first and/or second and/or third terminal when first and second currents flow and put the amounts of the voltages in relation to the coordinated currents such that line interruptions and/or short circuits can be detected at the first and/or second and/or third terminal.

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Номер записи: 51
25-10-2012 дата публикации

Fluid handling apparatus and fluid handling system

Номер: US20120266974A1
Автор: Ken Kitamoto
Принадлежит: Enplas Corp

Chip body 130 in which a through hole or concave is formed, intermediate film 140 , on one surface of which adhesive layer 150 ′ is formed and lower film 170 , on one surface of which transfer function layer 160 is formed, are prepared. Intermediate film 140 and lower film 170 are bonded together such that transfer function layer 160 is embedded in adhesive layer 150 ′ to form a laminated body. The laminated body and chip body 130 are bonded together by thermocompression to manufacture micro-chip 100.

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Номер записи: 52
25-10-2012 дата публикации

Ruggedized Apparatus for Analysis of Nucleic Acid and Proteins

Номер: US20120267247A1
Автор: Eugene Tan, Gregory John Kellogg, Heung Chuan Lam
Принадлежит: Netbio Inc

The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.

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Номер записи: 53
08-11-2012 дата публикации

Electrochemical ph measurement

Номер: US20120279874A1
Автор: Andrew Meredith, Nathan S. Lawrence
Принадлежит: Schlumberger Technology Corp

A method of measuring pH of aqueous liquid with little or no buffer present uses an electrochemical pH sensor which comprises a plurality of electrodes with a redox active organic compound attached to an electrode and having at least one functional group convertible electrochemically between reduced and oxidized forms with transfer of at least one proton between the compound and surrounding aqueous phase, wherein the compound has at least one substituent group which promotes hydrogen bonding at a said functional group and thereby increases the reaction rate of proton transfer. The substituent group may form an internal hydrogen bond with a redox-convertible group or may enhance polarity to promote electrostatic interaction with water molecules and reduce activation energy. Such an electrochemical sensor may be used for pH measurement in computer controlled equipment for processing an aqueous liquid.

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Номер записи: 54
08-11-2012 дата публикации

Method of enhanced detection for nanomaterial-based molecular sensors

Номер: US20120282594A1
Автор: Avetik R. Harutyunyan, Gugang CHEN
Принадлежит: Honda Motor Co Ltd

Sensors based on single-walled carbon nanotubes and graphene which demonstrate extreme sensitivity as reflected in their electrical conductivity to gaseous molecules, such as NO, NO 2 and NH 3 , when exposed to in situ ultraviolet (UV) illumination during measurement of the analytes are disclosed. The sensors are capable of detection limits of NO down to almost 150 parts-per-quadrillion (“ppq”), detection limits of NO 2 to 2 parts-per-trillion (“ppt”), and detection limits of NH 3 of 33 ppt.

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Номер записи: 55
08-11-2012 дата публикации

Potentiometric dna microarray, process for producing the same and method of analyzing nucleic acid

Номер: US20120283119A1
Автор: Kenji Yasuda, Kumiko Hattori, Yuji Miyahara
Принадлежит: Individual

A DNA microarray system whereby measurement can be performed at a low running cost, a low price and yet a high accuracy. A nucleic acid probe ( 3 ) is immobilized on the surface of a gate insulator of an electric field effect transistor and then hybridized with a target gene on the surface of the gate insulator. A change in the surface electric charge density thus arising is detected by using the electric effect.

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Номер записи: 56
15-11-2012 дата публикации

Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette

Номер: US20120285832A1
Автор: Norberto A. Guzman
Принадлежит: Individual

The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.

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Номер записи: 57
15-11-2012 дата публикации

Improved control method and device for oxygen pump cells of sensors in internal combustion engines or exhaust gas after treatment systems of such engines

Номер: US20120288376A1
Автор: Theophil Auckenthaler
Принадлежит: FPT Motorenforschung AG, Iveco Motorenforschung AG

It is described a method for controlling an oxygen pump cell of a sensor in an internal combustion engine or in the exhaust gas after treatment system of such an engine, comprising the step of adding, to a feedback control of the current in the pump cell, a further feed-forward control path estimating an expected oxygen pump current on the basis of characteristics of the exhaust gas composition calculated from engine operation data.

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Номер записи: 58
22-11-2012 дата публикации

Methods and apparatus for high-speed operation of a chemically-sensitive sensor array

Номер: US20120293158A1
Автор: James Bustillo, Jonathan M. Rothberg, Kim L. Johnson, Wolfgang Hinz
Принадлежит: Life Technologies Corp

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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Номер записи: 59
29-11-2012 дата публикации

Microchemical nanofactories

Номер: US20120298037A1
Автор: Brian Kevin Paul, Chih-Hung Chang, Vincent Thomas Remcho
Принадлежит: Oregon State Board of Higher Education, State University

Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement synthetic processes, disclosed embodiments of the apparatus generally include at least one unit operation, such as a mixer, a valve, a separator, a detector, and combinations thereof. Individual apparatuses may be coupled both in series and in parallel to form a system for making chemical compounds. An individual apparatus or a system also can be used in combination with known devices and processes.

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Номер записи: 60
06-12-2012 дата публикации

Gas sensor element and gas sensor employing the gas sensor element

Номер: US20120305397A1
Автор: Hirokatsu Imagawa
Принадлежит: Denso Corp

In a gas sensor element, a measurement gas is introduced to a measurement electrode through a porous diffusion-resistant layer. A catalyst layer is formed on an outer surface of the diffusion-resistant layer via which the measurement gas flows into the diffusion-resistant layer. In the catalyst layer, the percentage content of Pt is in the range of 2.5 to 12 mass %, the percentage content of Pd is in the range of 0.4 to 2 mass %, and the percentage content of Rh is in the range of 0.06 to 1.5 mass %. The catalyst layer includes catalytic noble metal particles each of which is made of an alloy that contains at least Pt. For each of the catalytic noble metal particles, the percentage content of Pt at an outer peripheral portion of the catalytic noble metal particle is lower than that at a core portion of the catalytic noble metal particle.

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Номер записи: 61
06-12-2012 дата публикации

Microchip for nucleic acid amplification reaction and a method of manufacturing the same

Номер: US20120309084A1
Автор: Hidetoshi Watanabe, Tasuku Yotoriyama, Tomoteru Abe
Принадлежит: Sony Corp

To provide a microchip for a nucleic acid amplification reaction which allows high-precision analysis by a simple method. There is provided a microchip A for a nucleic acid amplification reaction including an entrance through which a liquid enters from the outside, a plurality of wells configured to function as reaction sites of nucleic acid amplification reaction, and flow channels through which the liquid entered from the entrance is fed into each of the wells, in which a plurality of reagents needed for the reaction are laminated and anchored in a prescribed order in each well.

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Номер записи: 62
20-12-2012 дата публикации

Biochemical analysis instrument

Номер: US20120322679A1
Автор: Clive Gavin Brown, James Peter Willcocks
Принадлежит: Oxford Nanopore Technologies PLC

An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.

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Номер записи: 63
27-12-2012 дата публикации

Electrochemical detection of particulates in a gaseous sample using potentiometric measurements in a gaseous flame electrolyte

Номер: US20120325684A1
Автор: Daren J. Caruana, Dimitrios Sarantaridis
Принадлежит: UCL BUSINESS LTD

The present invention provides a method for the detection of particulates in a sample, wherein the particulates are introduced into a plasma and the potential difference between a common electrode and each of a plurality of indicator electrodes is measured. The invention further provides an electrode array and an apparatus which can be used for the potentiometric detection of particulates in a sample.

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Номер записи: 64
27-12-2012 дата публикации

Microwell structures for chemically-sensitive sensor arrays

Номер: US20120326213A1
Автор: James Bustillo, Mark Milgrew
Принадлежит: Life Technologies Corp

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

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Номер записи: 65
27-12-2012 дата публикации

Active chemically-sensitive sensors with source follower amplifier

Номер: US20120329043A1
Автор: Mark Milgrew
Принадлежит: Life Technologies Corp

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

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Номер записи: 66
27-12-2012 дата публикации

Graphene sensor

Номер: US20120329193A1
Автор: Chung-Hsun Lin, Dechao Guo, Ning Su, Shu-Jen Han
Принадлежит: International Business Machines Corp

A method for forming a sensor includes forming a channel in substrate, forming a sacrificial layer in the channel, forming a sensor having a first dielectric layer disposed on the substrate, a graphene layer disposed on the first dielectric layer, and a second dielectric layer disposed on the graphene layer, a source region, a drain region, and a gate region, wherein the gate region is disposed on the sacrificial layer removing the sacrificial layer from the channel.

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Номер записи: 67
03-01-2013 дата публикации

Chemically-sensitive field effect transistor based pixel array with protection diodes

Номер: US20130001653A1
Автор: James Bustillo, Mark Milgrew, Todd Rearick
Принадлежит: Life Technologies Corp

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

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Номер записи: 68
03-01-2013 дата публикации

Methods and apparatus for high speed operation of a chemically-sensitive sensor array

Номер: US20130004949A1
Автор: Todd Rearick
Принадлежит: Life Technologies Corp

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

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Номер записи: 69
03-01-2013 дата публикации

Dna analyzer

Номер: US20130004956A1
Автор: James P. Landers, Paul Kinnon
Принадлежит: ZyGEM Corp Ltd

Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.

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Номер записи: 70
10-01-2013 дата публикации

Electrophoresis apparatus

Номер: US20130008795A1
Автор: Gyula Vigh, Peniel Lim
Принадлежит: Individual

An electrophoresis apparatus for measuring, characterizing and/or altering a composition of a sample. The apparatus comprises an anode compartment having an anode and a cathode compartment having a cathode. The anode and cathode are spaced at a distance from one another to define an electric field having a direction along longitudinal axis, and between the anode and cathode compartments can be at least one separation compartment. Each compartment includes means for adding or removing a solution, a first dimension orthogonal to the direction of the electric field, a second dimension orthogonal to the electric field and the first dimension, and a third dimension parallel to the electric field and orthogonal to the first and second dimensions. A ratio of the first and second dimensions define an aspect ratio, at least one aspect ratio being less than one. An ion-permeable barrier is positioned between each compartment to prevent convective mixing therebetween.

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Номер записи: 71
07-02-2013 дата публикации

Plastic Microfluidic Separation and Detection Platforms

Номер: US20130032483A1
Автор: Cheuk Wai Kan, Eugene Tan, Heung Chuan Lam
Принадлежит: Netbio Inc

Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.

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Номер записи: 72
07-02-2013 дата публикации

Chamber free nanoreactor system

Номер: US20130034880A1
Автор: Mark F. Oldham
Принадлежит: Individual

Aspects of the invention include methods for improving the accuracy and read length of sequencing reactions by utilizing unlabeled unincorporable nucleotides, or by rephasing colony based sequencing reactions. Other aspects include systems and devices for improved measurement of biological reactions associated with bead which may be removed, utilizing current measurement methods through the counter ions associated with said beads due to the presence of reactants bound or associated with said bead, wherein electrodes for generating and measuring said current may be within the Debye length of said bead. Other aspects of the invention include methods for determining concentrations of input samples, means for reuse of an array, methods and apparatus for separating beads with different charge levels from each other.

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Номер записи: 73
07-02-2013 дата публикации

Diagnosing, prognosing and monitoring multiple sclerosis

Номер: US20130034910A1
Автор: Ariel Miller, Hossam Haick
Принадлежит: MOR RESEARCH APPLICATIONS LTD, Rappaport Family Institute for Research in the Medical Sciences, Technion Research and Development Foundation Ltd

The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.

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Номер записи: 74
14-02-2013 дата публикации

Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom

Номер: US20130039893A1
Автор: Toan-Thang Phan
Принадлежит: CellResearch Corp Pte Ltd

The present invention relates to the generation of a mucin-producing cell using stem/progenitor cells obtained from the amniotic membrane of umbilical cord and therapeutic uses of such mucin-producing cells.

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Номер записи: 75
07-03-2013 дата публикации

Ultrasensitive biosensors

Номер: US20130056839A1
Автор: James HOLM-KENNEDY
Принадлежит: UNIVERSITY OF HAWAII

The present invention is a biosensor apparatus that includes a substrate, a source on one side of the substrate, a drain spaced from the source, a conducting channel between the source and the drain, an insulator region, and receptors on a gate region for receiving target material. The receptors are contacted for changing current flow between the source and the drain. The source and the drain are relatively wide compared to length between the source and the drain through the conducting channel.

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Номер записи: 76
14-03-2013 дата публикации

AMMONIA GAS SENSOR

Номер: US20130062203A1
Автор: KAKIMOTO Shiro, KOJIMA Takio, NAKANO Yoshihiro, SUGAYA Satoshi, WATANABE Shuntaro
Принадлежит: NGK SPARK PLUG CO., LTD.

An ammonia gas sensor (A) having an oxygen ion conductive solid electrolyte member (A); a detection electrode (A) and a reference electrode (A) which are disposed on the solid electrolyte member; and an intermediate layer (A) interposing between the detection electrode and the solid electrolyte member; wherein the intermediate layer contains the oxygen ion conductive solid electrolyte component in an amount of 50 wt % or more, and a first metal oxide which is an oxide of at least one metal selected from the group consisting of Co, Mn, Cu, Ni, and Ce, and the detection electrode contains Au in an amount of 70 wt % or higher and no first metal oxide. 1. An ammonia gas sensor comprising:an oxygen ion conductive solid electrolyte member;a detection electrode and a reference electrode which are disposed on the solid electrolyte member; andan intermediate layer interposing between the detection electrode and the solid electrolyte member;wherein the intermediate layer contains the oxygen ion conductive solid electrolyte component in an amount of 50 wt % or more, and a first metal oxide which is an oxide of at least one metal selected from the group consisting of Co, Mn, Cu, Ni, and Ce, andthe detection electrode contains Au in an amount of 70 wt % or higher and no first metal oxide.2. An ammonia gas sensor according to as claimed in claim 1 , wherein the reference electrode is directly disposed on the solid electrolyte member.3. An ammonia gas sensor as claimed in claim 1 , wherein the intermediate layer contains the first metal oxide in an amount of 1 to 50 wt %.4. An ammonia gas sensor as claimed in claim 1 , wherein the intermediate layer comprises the solid electrolyte component deposited on the first metal oxide.5. An ammonia gas sensor as claimed in claim 1 , wherein the detection electrode is a porous electrode containing a second metal oxide which is an oxide of at least one metal selected from the group consisting of Zr claim 1 , Y claim 1 , Al claim 1 , and Si.6. ...

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Номер записи: 77
21-03-2013 дата публикации

ELECTROCHEMICAL GAS SENSOR AND METHOD FOR CLAMPING THE SAME

Номер: US20130068616A1
Автор: INOUE Tomohiro, KATO Yuki, SHIBATA Keiko
Принадлежит: FIGARO ENGINEERING INC.

An electrochemical gas sensor includes: a disc-shaped metal bottom member; a cylindrical metal side member that extends along the axial direction of the bottom member to surround the bottom member; a ring-shaped polymer gasket that includes an opening in the center and in which both sides of the opening each have an L-shaped member in cross section, with one section of the L-shaped member being in contact with the inner side of the side member and the other section of the L-shaped member being in contact with the bottom member; a gas sensor body that is located in the opening of the gasket and whose bottom surface is in contact with the bottom member and that includes a pair of electrodes and a solid electrolyte membrane or a separator retaining a liquid electrolyte; and a metal cover that is in contact with the top surface of the gas sensor body. 1. An electrochemical gas sensor comprising:a disc-shaped metal bottom member;a cylindrical metal side member that extends in at least a first direction along an axial direction of the bottom member so as to surround the bottom member;a ring-shaped polymer gasket that includes an opening in the center and in which at both sides of the opening each are an L-shaped member in cross section, with one section of the L-shaped member being in contact with an inner side of the side member and the other section of the L-shaped member being in contact with the bottom member;a gas sensor body that is located in the opening of the gasket and whose bottom surface is in contact with the bottom member, the gas sensor body including at least a pair of electrodes and a solid electrolyte membrane or a separator retaining a liquid electrolyte; anda metal cover whose bottom surface is circular and is in contact with a top surface of the gas sensor body,wherein the cover includes a ring-shaped protrusion provided around periphery of the cover and extending to a side opposite the bottom surface along the axial direction of the cover, anda tip ...

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Номер записи: 78
21-03-2013 дата публикации

Method and Apparatus for Detecting Nucleotides

Номер: US20130068619A1
Автор: Sauer Jon R., van Zeghbroeck Bart J.
Принадлежит: LIFE TECHNOLOGIES CORPORATION

A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid strand proximate to the detecting region, and a method for manufacturing such a semiconductor device. The system and method can thus be used for sequencing individual nucleotides or bases of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The semiconductor device includes at least two doped regions, such as two n-typed regions implanted in a p-typed semiconductor layer or two p-typed regions implanted in an n-typed semiconductor layer. The detecting region permits a current to pass between the two doped regions in response to the presence of the component of the polymer. 1. A method for detecting a polynucleotide , the method comprising:providing a voltage difference on the order of 100 mV between a first electrode and a second electrode disposed on opposite sides and remotely from a nanopore to direct the polynucleotide to the nanopore, the nanopore having an opening of between 1 nm and 3 nm diameter;detecting a change in ion current when the polynucleotide traverses the opening of the nanopore; andanalyzing the polynucleotide multiple times by directing the polynucleotide in and out of the opening by reversing polarity across the opening.2. A system for sequencing , the system comprising:a nanopore having an opening of between 1 nm and 3 nm, the nanopore to receive a nucleic acid strand;first and second electrodes disposed on opposite sides and remotely from the nanopore, the first and second electrodes to provide a voltage difference of about 100 mV;a current meter to detect a change in ion current when the nucleic acid strand is received by the nanopore; andthe system to analyzing the nucleic acid strand multiple times by directing the nucleic acid strand in ...

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Номер записи: 79
21-03-2013 дата публикации

METHODS AND APPARATUS FOR NANOMEMBRANE-BASED NUCLEIC ACID SENSING PLATFORM FOR PORTABLE DIAGNOSTICS

Номер: US20130068632A1
Автор: CHANG Hsueh-Chia, Cheng Li-Jing, Senapati Satyajyoti, Slouka Zdenek
Принадлежит: University of Notre Dame du Lac

A DNA/RNA detection technology is provided. The open flow detection technique includes a substrate defining a pair of opposing microchannels, a pair of opposing electrodes in the opposing microchannels, and at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule. A voltammeter is provided to measure the electrical current or potential across the nanomembrane, and detect a change in the measured electrical current or potential to quantify the presence of the macromolecule 1. A quantitative method for analyzing a macromolecule comprising:making an assay mixture containing the macromolecule; a substrate defining a pair of opposing microchannels;', 'a pair of opposing electrodes in the opposing microchannels;', 'at least one ion exchanging nanomembrane coupled between the opposing microchannels such that the opposing microchannels are connected to each other only through the nanomembrane, wherein the nanomembrane is functionalized with a probe complementary to the macromolecule; and', 'a device for measuring at least one of measuring electrical current or potential across the nanomembrane;, 'providing a microchamber electrochemical cell comprisingflowing the assay mixture through the opposing microchannels of the microchamber electrochemical cell such that assay mixture contacts the nanomembrane in a manner suitable for hybridization of the assay mixture with the probe;connecting the opposing electrodes to the device for measuring at least one of measuring electrical current or potential across the nanomembrane; anddetecting a change in the measured electrical current or potential across the nanomembrane to quantify the presence of the macromolecule.2. A method as defined in claim 1 , wherein the nanomembrane is provided in a nanoslot.3. A method as defined ...

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Номер записи: 80
21-03-2013 дата публикации

SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE

Номер: US20130068633A1
Автор: Chatelier Ronald C., Hodges Alastair M., Nandagopalan Santhanagopalan
Принадлежит: LifeScan, Inc.

Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error. 1. A method of identifying a defect in a test strip , comprising:{'sub': 1', '1, 'applying a first test voltage Vfor a first test time interval Tbetween a first electrode and a second electrode sufficient to oxidize a reduced mediator at the second electrode;'}{'sub': 2', '2, 'applying a second test voltage Vfor a second test time interval Tbetween a first electrode and a second electrode sufficient to oxidize a reduced mediator at the first electrode;'}{'sub': 1', '2', '2', '2', '1, 'measuring a first test current iand a second test current ithat occur during the second test time interval T, the second test current ioccurring after the first test current i; and'}{'sub': 1', '2, 'determining whether the test strip has the defect using an equation based on the first test current iand the second test current i.'}2. The method of claim 1 , wherein the second test voltage Vis applied immediately after the first test voltage V.3. The method of claim 1 , wherein the equation comprises a ratio between the first test current iand the second test current i.4. The method of claim 3 , wherein the equation comprises a ratio between the first test current iand the difference between the first test current iand the second test current i.5. The method of claim 1 , wherein the first test ...

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Номер записи: 81
21-03-2013 дата публикации

Microwell structures for chemically-sensitive sensor arrays

Номер: US20130071915A1
Автор: James Bustillo, Mark Milgrew
Принадлежит: Life Technologies Corp

Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

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Номер записи: 82
28-03-2013 дата публикации

Method and test device for field calibration of a gas detector

Номер: US20130074575A1
Автор: Aleksandar Duric, Harald Ebner, Martin Förster
Принадлежит: SIEMENS AG

A method and test devices are used for field calibration of gas detectors. Brand new gas detectors are used as measurement standards in field calibration. The brand new gas detectors are in this case either employed directly as working standards, in which case the regular calibration by a reference standard is dispensed with, since the brand new gas detectors are always deemed to be sufficiently accurate. Alternatively, the brand new gas detectors are employed directly, namely as sufficiently accurately calibrated reference standards for the reference gas sensors acting as working standards and incorporated into the test device. In both cases the measured values of the gas sensors in the gas detectors to be calibrated are fed back to a sufficiently calibrated system, namely either directly to at least one brand new gas detector as a working standard or else to a reference sensor of a calibrated test device.

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Номер записи: 83
28-03-2013 дата публикации

Flow Step Focusing

Номер: US20130075257A1
Автор: Peter B. Howell, JR.
Принадлежит: US Department of Navy

Flow step focusing isolates and concentrates a molecule of interest by flowing a liquid comprising a molecule of interest through a main channel having an inlet and an outlet with application of a first pressure at the inlet; applying a voltage along the channel during the flowing, wherein the voltage is configured to have a polarity such that it drives the molecule of interest in a direction opposite the flow of the liquid; controlling the first pressure and/or the voltage in a manner so as to trap and concentrate the molecule of interest in a region of the main channel; and removing the concentrated molecule of interest from the channel by recovering a portion of the liquid from a side channel diverging from the main channel, wherein the side channel is maintained at a pressure lower than the first pressure. Also disclosed is an apparatus for such.

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Номер записи: 84
28-03-2013 дата публикации

ELECTROPHORETICALLY ENHANCED DETECTION OF ANALYTES ON A SOLID SUPPORT

Номер: US20130075261A1
Автор: Feldman Galia, Lifshits Svetlana, MARGALIT Ilana
Принадлежит: LIFE TECHNOLOGIES CORPORATION

The present embodiments provide systems, kits and methods suitable for performing dry or substantially dry electro-blotting analyses on immobilized protein or nucleic acid samples. Electro-blotting performed according to the presently described embodiments may include a step whereby detection of one or more immobilized proteins or nucleic acids is electrophoretically accelerated. Methods for performing electro-blotting of immobilized proteins or nucleic acids may include applying an electric voltage to one or more reagents typically used in protein or nucleic acid blotting procedure. The one or more reagents may be absorbed on a suitable carrier matrix. Electro-blotting performed in accordance with the systems and methods described herein may be performed under substantially dry conditions (i.e., with little or no aqueous buffers). 1. A system comprising:a first gel matrix body;a second gel matrix body; andat least a first carrier matrix;wherein the first gel matrix body and the second gel matrix body comprise a source of ions for electrophoresis, and wherein the carrier matrix comprises a material capable of substantially reversibly absorbing a proteinaceous or hybridization composition.2. The system according to claim 1 , wherein the first carrier matrix is positioned between the first gel matrix body and the second gel matrix body.3. The system according to claim 1 , wherein a surface of the first carrier matrix is substantially juxtaposed with a surface of the first gel matrix body.4. The system according to claim 1 , wherein the first carrier matrix comprises a proteinaceous composition absorbed thereon.5. The system according to claim 4 , wherein the carrier matrix comprises between about 0.1 μg to about 10 mg of the proteinaceous composition.6. The system according to claim 4 , wherein at least a portion of the proteinaceous or hybridization composition is at least partially negatively charged.7. The system according to claim 4 , wherein the proteinaceous or ...

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Номер записи: 85
28-03-2013 дата публикации

NANO-ELECTRONIC SENSORS FOR CHEMICAL AND BIOLOGICAL ANALYTES, INCLUDING CAPACITANCE AND BIO-MEMBRANE DEVICES

Номер: US20130075794A1
Автор: Bradley Keith, Chang Ying-Lan, Gabriel Jean-Christophe P., Passmore John Loren, Skarupo Sergei, Tu Eugene, Valcke Christian
Принадлежит:

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes inorganic gases, organic vapors, biomolecules, viruses and the like. A number of embodiments of capacitive sensors having alternative architectures are described. Particular examples include integrated cell membranes and membrane-like structures in nanoelectronic sensors. 1. A sensor , comprising:a substrate;a conductive base disposed adjacent the substrate;a dielectric material covering at least a region of the conductive base;one or more nanostructures disposed adjacent the dielectric material and capacitively coupled to the conductive base; anda top lead electrically communicating to the one or more nanostructures.2. The sensor of claim 1 , wherein the one or more nanostructures comprises a network of carbon nanotubes.3. The sensor of further comprising a functionalization material disposed adjacent the carbon nanotubes.4. A sensor claim 2 , comprising:a substrate;a spaced-apart pair including a first and second conductive lead disposed adjacent the substrate;a dielectric material covering at least a region of at least one conductive lead; andone or more nanostructures disposed adjacent the dielectric material and capacitively coupled to at least one conductive lead.5. The sensor of claim 4 , wherein the one or more nanostructures comprises an electrically-continuous network including a plurality of carbon nanotubes spanning to cover at least a region of each conductive lead which separated from each lead by the dielectric material claim 4 , and wherein neither conductive lead is in contact with the network of carbon nanotubes.6. The sensor of claim 5 , wherein the spaced-apart pair of conductive leads have a characteristic separation gap “g” claim 5 , and wherein the carbon nanotubes have a characteristic length “L” claim 5 , and wherein “L” is significantly greater that “g”.7. The sensor of claim 5 , wherein substantial numbers of nanotubes span the gap so as to have ...

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Номер записи: 86
04-04-2013 дата публикации

Ion-Selective Ion Concentration Meter

Номер: US20130084214A1
Автор: Frederick Quincy Johnson, Henry Roskos, Mark Bain
Принадлежит: Individual

An ion concentration meter measures a concentration of an ion in a solution by exposing both an ISFET gate and a reference electrode within a filtered test area. In preferred embodiments, the test area filters preferred compounds from a solution being tested by occluding an opening to the test area with a species-selective membrane. Contemplated species-selective membranes include silicate membranes, chalcogenide membranes, lanthanum fluoride membranes, and valinomycin membranes.

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Номер записи: 87
11-04-2013 дата публикации

MICRO-ASSAY CHIP, ASSAY DEVICE USING SAID MICRO-ASSAY CHIP AND PUMPING METHOD

Номер: US20130087458A1
Автор: Kitagawa Toshiaki, Mieda Michinobu
Принадлежит: SHARP KABUSHIKI KAISHA

A microanalysis chip includes: a main flow channel () having one end connected to an open hole () open to an outside; a first introduction flow channel () through which a first liquid () is introduced into the main flow channel (); a first discharge flow channel () through which a first liquid () introduced into the main flow channel () is discharged; and a reacting and detecting section () which, inside of the main flow channel (), analyzes a property of the first liquid () introduced into the main flow channel (), the first introduction flow channel () and the first discharge flow channel () being both provided at a side of the main flow channel () that is opposite to the open hole () with respect to the reacting and detecting section (). Therefore, a solution is quantitatively weighed out with a simple configuration, and the solution thus weighed out is analyzed with the solution kept charged into a flow channel. 1. A microanalysis chip comprising:a main flow channel having one end connected to an open hole open to an outside;a first introduction flow channel through which a solution is introduced into the main flow channel;a first discharge flow channel through which a solution introduced into the main flow channel is discharged; andan analyzing section provided in the main flow channel so as to analyze a property of the solution introduced into the main flow channel,the first introduction flow channel and the first discharge flow channel being both provided at a side of the main flow channel that is opposite to the open hole with respect to the analyzing section.2. The microanalysis chip as set forth in claim 1 , wherein the maim flow channel claim 1 , the first introduction flow channel claim 1 , and the first discharge flow channel each have flow channel inner surfaces at least part of which is made of a hydrophilic material so that a liquid is able to be transferred with capillary force as driving force.3. The microanalysis chip as set forth in claim 1 , ...

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Номер записи: 88
18-04-2013 дата публикации

Electrochemical detection cell for liquid chromatography system

Номер: US20130091936A1
Автор: Christopher A. Pohl, Jun Cheng, Petr Jandik
Принадлежит: Dionex Corp

A detection cell for a chromatography system includes a cell body having an inlet, an outlet, and a counter electrode, a working electrode, a sample flow passageway extending between the inlet and the outlet and in fluid contact with the counter and working electrodes, and a palladium/noble metal reference electrode system. A method of using the detection cell is also described.

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Номер записи: 89
18-04-2013 дата публикации

Gas sensor element and gas sensor

Номер: US20130092537A1
Автор: Keigo Mizutani, Norikazu KAJIYAMA
Принадлежит: Denso Corp

The gas sensor element includes an inner space into which a measurement gas is introduce through a diffusion resistor, a first oxygen pump cell, a second oxygen pump cell and a sensor cell. One of the electrodes formed on the opposite surfaces of the solid electrolyte body of the first oxygen pump cell and one of the electrodes formed on the opposite surfaces of the second oxygen pump cell are disposed opposite to each other across from the inner space. The other electrode of the first oxygen pump cell and the other electrode of the second oxygen pump cell are exposed to a common reference oxygen concentration gas.

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Номер записи: 90
18-04-2013 дата публикации

LOW-TEMPERATURE ACTIVITY EXHAUST SENSOR

Номер: US20130092538A1
Автор: Clyde Eric P., Nottingham Marsha E., Polikarpus Kaius K., Symons Walter T., Ward James D.
Принадлежит: DELPHI TECHNOLOGIES, INC.

An exhaust sensor comprises a sensing electrode and a reference electrode each in contact with an electrolyte. At least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material on an electrolyte precursor material and sintering the combination at a sufficient temperature for a sufficient time to achieve densification of the electrolyte, wherein the electrode precursor material comprises an alkali salt. Electrode patterns having enhanced perimeter ratios are also disclosed. The resulting exhaust sensor is capable of providing a usable output at a reduced operating temperature. 1. An exhaust sensor comprising a sensing electrode and a reference electrode each in physical contact with an electrolyte;wherein at least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material configured as a pattern on an electrolyte precursor material and sintering the combination at a sufficient temperature for a sufficient time to achieve densification of the electrolyte,wherein the electrode precursor material comprises an alkali salt,wherein the perimeter of at least one of the sensing electrode and the reference electrode is greater than the perimeter of the smallest rectangle that can be defined to completely enclose the pattern of said sensing electrode or said reference electrode by an amount sufficient to produce a sensor impedance after sintering less than 200 ohms at a sensor temperature at or below 450 degrees C.2. The exhaust sensor of claim 1 , wherein the electrode precursor material additionally comprises yttria-stabilized zirconia.3. The exhaust sensor of claim 1 , wherein the alkali salt is a potassium salt.4. An exhaust sensor comprising a sensing electrode and a reference electrode each in physical contact with an electrolyte;wherein at least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material ...

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Номер записи: 91
18-04-2013 дата публикации

DROPLET-BASED NUCLEIC ACID AMPLIFICATION METHOD AND APPARATUS

Номер: US20130092539A1
Автор: Paik Philip Y., Pamula Vamsee K., Pollack Michael G.
Принадлежит:

Aspects of embodiments of the invention relate to a simulator including a visual display capable of outputting to a user a display one or more effects of a command series selected and a system including a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, the droplet microactuator including a substrate comprising electrodes for conducting droplet operations. Further aspects of embodiments of the invention relate to a droplet operations troubleshooting apparatus. Other aspects of embodiments of the invention relate to a computer implemented method of displaying simulated microactuator droplets. 1. A simulator comprising:(a) a visual display capable of outputting to a user a display of one or more effects of a command series selected; and(b) a system comprising a droplet microactuator electronically coupled to and controlled by a processor capable of executing instructions, the droplet microactuator comprising a substrate comprising electrodes for conducting droplet operations.2. The simulator of claim 1 , wherein the visual display further comprises a screen to illustrate to the user the actual effect of a program.3. The simulator of claim 1 , wherein the visual display further comprises a screen to illustrate to the user the simulated effect of a droplet microactuator.4. The simulator of claim 1 , wherein the visual display further comprises a screen to illustrate a simulated execution of a subroutine on a droplet microactuator map.5. The simulator of claim 1 , further comprising executable instructions that are stored on a computer readable medium.6. The simulator of claim 1 , wherein software executes steps of a subroutine but does not send an electrical signal to the droplet microactuator.7. The simulator of claim 1 , wherein the droplet microactuator further comprises one or more temperature control means arranged in proximity with one or more of the electrodes for heating a region of the droplet ...

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Номер записи: 92
18-04-2013 дата публикации

High-Resolution Analysis Devices and Related Methods

Номер: US20130092541A1
Автор: Dadosh Tali, Drndic Marija, Wanunu Meni
Принадлежит: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

Disclosed are solid-state nanopore devices having pores of nanometer-scale thickness, which ultrathin (e.g., less than 10 nm thick) pores enable devices having improved resolution. Also provided are methods of fabricating such devices and of using such devices. The invention also provides nanometer-thick membranes and related methods of fabricating such membranes, which membranes are useful in high resolution microscopy applications. Further disclosed are devices for detection of analytes—including miRNA—that may be small in size and may also be present in only small quantities. 1. A detection device , comprising:a first capture material configured to bind preferentially to a first molecule;a membrane having a thickness in the range of from about 20 nm to about 100 nm, and the membrane having a thinned region,the thinned region having a thickness in the range of from about 0.1 nm to about 20 nm, anda first pore extending through the thinned region,the first pore being in fluid communication with the capture material; anda detector configured to detect a signal related to passage of the first molecule through the first pore.2. The detection device of claim 1 , wherein the first molecule comprises miRNA.3. The detection device of claim 1 , wherein the first capture material is selected to as to bind preferentially to miRNA.4. The detection device of claim 3 , wherein the first capture material binds preferentially to a preselected miRNA.5. The detection device of claim 1 , further comprising a second capture material that binds preferentially to a second miRNA molecule that differs in at least one aspect from the first miRNA molecule.6. The detection device of claim 1 , wherein the first pore comprises a cross-sectional dimension in the range of from about 1 nm to about 100 nm.7. The detection device of claim 1 , wherein the thinned region comprises a cross-sectional dimension in the range of from about 10 nm to about 10 micrometers.8. A method of detecting an analyte ...

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Номер записи: 93
18-04-2013 дата публикации

STEP-CHANGE SENSOR FOR PUMPED AND UNPUMPED OPERATION

Номер: US20130092559A1
Автор: Diehl Lothar, Kruse Peer, Peters Christoph, Schneider Gerhard, Schneider Jens
Принадлежит: ROBERT BOSCH GMBH

A sensor device for sensing at least a proportion of at least one gas component of a gas in a measurement gas space, in particular for detecting oxygen in an exhaust gas of a combustion machine, is proposed. The sensor device includes at least one sensor element. The sensor element includes at least one first electrode and at least one first reference electrode and at least one second reference electrode. The second reference electrode is connected to at least one reference gas channel. The first electrode is connected to the first reference electrode and the second reference electrode by at least one respective solid electrolyte. The sensor element has at least one diffusion element between the first reference electrode and the reference gas channel. 1. A sensor device for sensing at least a proportion of at least one gas component of a gas in a measurement gas space , comprising:at least one sensor element including at least one first electrode, at least one first reference electrode, and at least one second reference electrode, wherein the second reference electrode is connected to at least one reference gas channel, the first electrode is connected to the first reference electrode and the second reference electrode by at least one respective solid electrolyte, the sensor element further includes at least one diffusion element which is connected to the first reference electrode.2. The sensor device as recited in claim 1 , wherein the sensor device is for detecting oxygen in an exhaust gas of a combustion machine.3. The sensor device as recited in claim 1 , wherein the diffusion element is at least partially disposed between the first reference electrode and the reference gas channel.4. The sensor device as recited in claim 1 , wherein the first reference electrode is connected to the reference gas channel claim 1 , a gas exchange between the first reference electrode and the reference gas channel through the diffusion element being made possible by the diffusion ...

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Номер записи: 94
18-04-2013 дата публикации

DEVICE FOR SORTING, CLASSIFYING, AND ASSAYING PARTITION BEHAVIOR OF CELL MEMBRANE BIOMOLECULES AND METHODS BASED THEREON

Номер: US20130095512A1
Автор: Chao Ling, Daniel Susan
Принадлежит: CORNELL UNIVERSITY

A biomolecule partitioning device (BPD) is provided that can be used to separate and sort membrane species into raft-like membrane regions without using detergent or crosslinkers. The BPD can comprise one or more microfluidic channels coated with coexistent lipid phases (raft-like and fluid-like lipid compositions) as a contiguous supported lipid bilayer (SLB). The geometry of the phases can be patterned with spatial and temporal control within each channel. Methods for the separation and sorting are also provided. The method can comprise the steps of introducing cell membrane species into an SLB; patterning coexistent phases; applying an electric field or hydrodynamic flow to move the species; sorting migrating species into regions based on their partitioning preference; and collecting sorted species in a quantification area. The BPD can also be used to measure partitioning kinetics or to assay for activity changes of biomolecules as a function of local lipid environment. 1. A biomolecule partitioning device (BPD) for partitioning biomolecules comprising:a substrate;a microfluidic channel on the substrate;a plurality of stable coexistent lipid phases, wherein the surface of the microfluidic channel is coated with a plurality of stable, coexistent lipid phases, thereby forming a supported lipid bilayer.2. The BPD of wherein the biomolecules are cell membrane species.3. The BPD of wherein the plurality of stable coexistent lipid phases comprises a raft-like or a fluid-like lipid composition.4. The BPD of wherein the phospholipid-containing region is a raft phase or raft-like region claim 1 , a 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)-rich region claim 1 , a cholesterol (Chol) -rich region or a N-palmitoyl-D-erythro-sphingosylphosphorylcholine (PSM)-rich region.5. The BPD of wherein the plurality of stable coexistent lipid phases are patterned within the microfluidic channel.6. The BPD of comprising a cushion for reducing strong protein interaction with ...

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Номер записи: 95
25-04-2013 дата публикации

METHOD FOR PRODUCING REACTION INSTRUMENT FOR ELECTROPHORESIS, APPARATUS FOR PRODUCING REACTION INSTRUMENT FOR ELECTROPHORESIS, BASE FOR GEL IMMOBILIZATION, REACTION INSTRUMENT FOR ELECTROPHORESIS AND KIT FOR ELECTROPHORESIS

Номер: US20130098764A1
Автор: Maruo Yuji, Ohki Hiroshi, Tanaka Tsuyoshi, Unuma Yutaka, Yamaki Hiroshi
Принадлежит: SHARP KABUSHIKI KAISHA

A production method of the present invention is a method of producing a reaction instrument for electrophoresis (), which is constituted by (i) a substrate () and (ii) an electrophoresis gel () which is immobilized on the substrate (), including the steps of: (i) discharging a liquid to a surface of the substrate () on which surface the gel is to be immobilized, thereby forming a liquid pool (); and thereafter (ii) discharging a gel solution to the liquid pool (). This provides a method of producing a reaction instrument for electrophoresis, which method makes it possible to form a gel with high reliability in high yield. 1. A method of producing a reaction instrument for electrophoresis , which reaction instrument is constituted by a base and an electrophoresis gel immobilized on the base , comprising the steps of:(1) discharging a liquid to a surface of the base on which surface the electrophoresis gel is to be immobilized, thereby forming a liquid pool on the surface; and thereafter(2) discharging a gel solution to the liquid pool.2. The method according to claim 1 , wherein the step (2) includes discharging the gel solution with use of an ink-jet head.3. The method according to claim 1 , further comprising claim 1 , after the step (2) claim 1 , the step (3) of discharging a polymerization initiator to the liquid pool.4. The method according to claim 1 , in a case where at least part of the surface on which the electrophoresis gel is to be immobilized is made of a hydrophobic material claim 1 , further comprising claim 1 , before the step (1) claim 1 , the step of carrying out a hydrophilizing treatment with respect to a region where the liquid pool is to be formed.5. The method according to claim 4 , wherein the step of carrying out the hydrophilizing treatment includes carrying out an oxygen plasma treatment.6. The method according to claim 1 , in a case where at least part of the surface on which the electrophoresis gel is to be immobilized is made of a ...

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Номер записи: 96
25-04-2013 дата публикации

Detection of Phenols

Номер: US20130098779A1
Автор: Banks Craig Edward, Compton Richard Guy
Принадлежит: ISIS INNOVATION LIMITED

According to the present invention, phenols may be detected using an electrochemical sensor comprising a first compound, a working electrode and an electrolyte in contact with the working electrode, wherein the first compound operatively undergoes a redox reaction at the working electrode to form a second compound which operatively reacts in situ with the phenol, wherein said redox reaction has a detectable redox couple and wherein the sensor is adapted to determine the electrochemical response of the working electrode to the consumption of said second compound on reaction with the phenol. The phenol may be, for example, a cannabinoid or a catechin compound. 123.-. (canceled)24. A method of detecting a phenol in a sample , comprising:(a) oxidising a first compound at a working electrode of an electrochemical sensor to form a second compound which is operatively reactive with the phenol;(b) contacting the phenol with the second compound in the presence of an electrolyte, such that the second compound reacts with the phenol; and(c) determining an electrochemical response of the working electrode to the consumption of the second compound on reaction with the phenol;wherein the first compound in step (a) is a 4-aminophenol, and wherein the second compound reacts to covalently bind the phenol in step (b).25. (canceled)27. The method according to claim 26 , wherein m is 0 claim 26 , 1 or 2.28. The method according to claim 26 , wherein the or each Ris independently selected from —NRR claim 26 , halogen claim 26 , C claim 26 , C claim 26 , Cor Calkyl claim 26 , C claim 26 , C claim 26 , Cor Chaloalkyl claim 26 , C claim 26 , C claim 26 , Cor Calkoxy claim 26 , and C claim 26 , Cor Calkenyl claim 26 , and wherein Rand Rare each independently selected from hydrogen claim 26 , —OH claim 26 , C claim 26 , C claim 26 , Cor Calkyl claim 26 , C claim 26 , C claim 26 , Cor Chaloalkyl claim 26 , C claim 26 , C claim 26 , Cor Calkoxy claim 26 , and C claim 26 , Cor Calkenyl.29. The ...

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Номер записи: 97
25-04-2013 дата публикации

SENSING AND SENSORS

Номер: US20130098780A1
Автор: Constandinou Timothy G., Georgiou Pantelis, PRODROMAKIS Themistoklis, TOUMAZOU Christofer
Принадлежит: DNA Electronics Limited

A sensor system comprising a substrate and integrated onto the substrate an array () of sensor elements (), each sensor element comprising one or more inductors (), one or more electrochemical sensors (), and one or more optical sensors (). The system further comprising a controller configured in use to separately address each of the sensor elements () to drive the respective inductors and receive outputs of the respective sensors. 1. A sensor system comprising a substrate and , integrated onto the substrate , a sensor element , the sensor element comprising one or more inductors , one or more electrochemical sensors , and one or more optical sensors , the sensor system further comprising a controller configured in use to drive the one or more inductors and to monitor outputs of the sensors in order to provide a sensor element result.2. A sensor system according to and comprising an array of said sensor elements claim 1 , said controller being configured in user to separately drive the inductors and monitor the sensors of each sensor element.3. A sensor system according to claim 1 , wherein the sensor elements are fabricated using a CMOS process.4. A sensor system according to claim 1 , wherein the one or more inductors are microcoils.5. A sensor system according to claim 4 , wherein the sensors of each sensor element are located substantially within each associated inductor microcoil.6. A sensor system according to claim 1 , further comprising a structure defining channels arranged to control the flow of media across the sensor elements.7. A sensor system according to claim 1 , further comprising a structure defining wells on top of the sensor elements for separating groups of media.8. A method of observing biological or chemical activity comprising providing a sample to be observed on or adjacent to a sensor system having a sensor system comprising a substrate and claim 1 , integrated onto the substrate claim 1 , a sensor element claim 1 , the sensor element ...

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Номер записи: 98
02-05-2013 дата публикации

Measurement Circuit for a Breath Alcohol Device

Номер: US20130104624A1
Автор: Devine Donovan Paul
Принадлежит: PFK Electronics (Pty) Ltd.

Measuring ethanol vapour concentration comprising; introducing an ethanol vapour sample into a fuel cell that is adapted to generate an output which is proportional to the ethanol vapour concentration of the ethanol sample; a voltage measurement circuit; a current measurement circuit; and means to switch the fuel cell output either to the voltage measurement circuit or to the current measurement circuit in dependence on one or more predetermined signal measurement parameters. The signal measurement parameter may be the temperature of the fuel cell. 1. A method of measuring ethanol vapour concentration in a breath alcohol concentration measurement device that includes a fuel cell adapted to generate an output proportional to the ethanol vapour concentration of an ethanol vapour sample introduced into the fuel cell , a voltage measurement circuit , a current measurement circuit and means to switch the fuel cell output either to the voltage measurement circuit or to the current measurement circuit , the method comprising the steps of:introducing an ethanol vapour sample into the fuel cell;generating a fuel cell output which is proportional to the vapour concentration; andin dependence on one or more predetermined signal measurement parameters, switching the fuel cell output either to a voltage measurement circuit or to a current measurement circuit.2. The method of measuring ethanol vapour concentration according to claim 1 , further comprising claim 1 , in the voltage measurement circuit claim 1 , measuring the potential difference between the fuel cell electrodes directly.3. The method of measuring ethanol vapour concentration according to claim 1 , further comprising claim 1 , in the voltage measurement circuit claim 1 , measuring the potential difference between the fuel cell electrodes across a shunt resistor.4. The method of measuring ethanol vapour concentration according to claim 1 , further comprising claim 1 , in the current measurement circuit claim 1 , ...

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Номер записи: 99
02-05-2013 дата публикации

Gas sensor element and gas sensor

Номер: US20130104625A1
Автор: Ken MITSUOKA, Kuniharu Tanaka, Masaki Onkawa, Satoshi Teramoto, Sigehiro OTSUKA, Takeshi Mitsuoka, Toru Iwano
Принадлежит: NGK Spark Plug Co Ltd

A gas sensor element ( 100 ) includes a laminate of a detection element ( 300 ) and a heater ( 200 ), and a porous protection layer ( 20 ) covering a forward end portion thereof. The laminate has a measuring chamber ( 107 c ) into which a gas-to-be-measured is introduced via a diffusion resistor ( 115 ). The porous protection layer includes an inner porous layer ( 21 ), and an outer porous layer ( 23 ). The inner porous layer has a higher porosity than the outer porous layer and the diffusion resistor. As viewed in a plurality of 100 μm×100 μm regions a 1 to a 3 and b 1 to b 3 on sections of the inner porous layer and the diffusion resistor, respectively, a pore diameter greater than the greatest pore diameter C DIF in the regions of the diffusion resistor exists in each of the regions of the inner porous layer.

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Номер записи: 100