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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 15383. Отображено 100.
05-01-2012 дата публикации

Liquid chromatograph device

Номер: US20120000836A1
Автор: Takao OKADO
Принадлежит: Shimadzu Corp

A liquid chromatograph device was provided wherein operations inside a thermostatic chamber can be safely performed even while a heat block is being heated. The liquid chromatograph device comprises: a thermostatic chamber; outer doors and that are disposed at the front surface of the thermostatic chamber; a heat block; heater for heating said heat block; temperature sensor for the heat block; flowing means for flowing air between the inside and outside of the thermostatic chamber; a control means for controlling the supply of power to the heater based on the result of the temperature sensor; and an inner door between the outer door and the heat block, the inner door comprising a hollow inner door main body, a heat-insulating material that is housed within the inner door so as to form an air chamber between the heat-insulating material and the surface of the outer door of the inner door main body and inlet/outlet slits and that are formed in the inner door main body. These slits and the flowing means causes air within the inner door to flow out, thus reducing the temperature of the inner door.

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Номер записи: 1
16-08-2012 дата публикации

Gradient start up system

Номер: US20120205314A1
Автор: Dale A. Davison
Принадлежит: Teledyne Instruments Inc

To provide or maintain pump prime in a liquid chromatographic system when changing solvents or solvent reservoirs or starting up a chromatographic run, first and second solvents are supplied to a mixer through corresponding first and second lines and from the mixer to a chromatographic column. Air in one of the lines is removed by a pump and the line is filled with solvent.

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Номер записи: 2
13-09-2012 дата публикации

Chromatography of polyolefin polymers

Номер: US20120227469A1
Автор: Abhishek Roy, Alexander W. Degroot, David M. Meunier, Freddy Van Damme, John W. Lyons, Matthew D. Miller, Randy J. Pell, Rongjuan Cong, Theodore M. Stokich, Jr., William L. Winniford
Принадлежит: Dow Global Technologies LLC

The invention provides a method for one-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero, and wherein the solution introduced into the liquid chromatography stationary phase is subjected to a temperature gradient, and/or the solution is subjected to a solvent gradient. The invention also provides a method for multi-dimensional chromatography of a polyolefin polymer, comprising introducing a solution of the polyolefin polymer into a liquid flowing through a first liquid chromatography stationary phase or a field flow fractionation device, and subsequently flowing the solution through a second liquid chromatography stationary phase, the second liquid chromatography stationary phase comprising graphitic carbon, and wherein the polyolefin polymer emerging from the liquid chromatography stationary phase has a retention factor greater than zero. The invention also provides an apparatus for polyolefin polymer chromatography, comprising a liquid chromatography stationary phase, the liquid chromatography stationary phase comprising graphitic carbon and at least one inert filler.

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Номер записи: 3
15-11-2012 дата публикации

Thermal control of thermal chamber in high-performance liquid chromatography systems

Номер: US20120285872A1
Автор: Joshua A. Shreve, Steven J. Ciavarini
Принадлежит: Waters Technologies Corp

A sample manager of a liquid chromatography system implements a thermal system that uses a dual-loop feedback control system to control temperature within a thermal chamber. The sample manager includes an external heatsink disposed externally to the thermal chamber, an internal heatsink disposed within the thermal chamber, and one or more thermoelectric devices thermally coupled to the external and internal heatsinks to transfer heat therebetween in response to a pulse-width modulated power signal. A first temperature sensor disposed within the thermal chamber continuously measures a chamber temperature. A second temperature sensor coupled to the internal heatsink within the thermal chamber continuously measures temperature at the internal heatsink. A feedback control system controls a duty cycle of the pulse-width modulated power signal in response to a target chamber temperature and real-time temperature measurements produced by the first and second temperature sensors.

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Номер записи: 4
23-05-2013 дата публикации

METHOD AND APPARATUS FOR INSPECTING A GAS SAMPLE

Номер: US20130125620A1
Автор: Linenberg Amos, Ovadia Yuval
Принадлежит: S.T.I. Security Technology Integration Ltd.

An apparatus for detecting a presence of at least one analyte in a gas sample. The apparatus comprises a pump for drawing a gas sample from an ambient air, a passage having first and second ends, a chamber connected to the first end and containing a concentrating element for collecting at least one analyte from the gas sample, a chromatographic separator connected to a second end of the passage, and a gas source for streaming a carrier gas via the chamber to transfer the at least one analyte toward at least one chemical detector, via the chromatographic separator, in a first direction. The pump draws the gas sample via the chamber in a second direction and the first and second directions are substantially opposing to one another. 1. A method for inspecting a gas sample , comprising:a) drawing a gas sample through a chamber having a concentration element so as to allow at least one analyte from said gas sample to be bonded thereto;b) extracting impurities from said chamber by streaming a carrier gas toward a first outlet therethrough;c) heating said concentration element to release said at least one bonded analyte;d) streaming said carrier gas via said chamber so as to carry said at least one released analyte toward a second outlet, via a chromatographic separator and a detection unit; ande) reading an output of said detection unit for detecting at least one of the presence, the absence and the concentration of said at least one analyte.2. The method of claim 1 , wherein said streaming is performed during a period of less than 10 seconds.3. The method of claim 1 , wherein said b)-e) are performed in less than 20 seconds.4. The method of claim 1 , wherein said b)-e) are performed in less than 10 seconds.5. The method of claim 1 , further comprising 0 cooling said concentration element in less than 10 seconds.6. The method of claim 5 , wherein said a)-f) are iteratively performed in detection cycles of less than 1 minute.7. The method of claim 1 , wherein said heating ...

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Номер записи: 5
06-06-2013 дата публикации

Devices for heating and cooling a capillary liquid chromatographic system

Номер: US20130139574A1
Автор: Staats Sau Lan Tang
Принадлежит: Phoenix S&T, Inc.

Devices for heating and cooling chromatographic columns, transfer tubing, fittings and accessories and can also be placed next to the mass spectrometer's inlet region are disclosed. These devices have the advantage of allowing the user to dramatically reduce the post-column dead-volume while using the heating or cooling devices, a necessity for low-flowrate liquid chromatography. These devices also do not require the user to heat or cool the entire column with fittings to achieve optimized benefits for chromatography. 1) A device suitable for use to heat or cool a capillary tube used in a liquid chromatography system at least one temperature-varying surface that can be placed in good thermal contact with a part of or the whole capillary tube;', 'at least one entrance and one exit opening for the capillary tube;', 'at least one active temperature-varying element;', 'at least one temperature sensor;', 'at least two layers of thermal insulation where two of the layers of insulation are in the form of concentric tubes with a slit down the length of each tube; and', 'a housing cover., 'comprising2) The device of claim 1 , where the temperature sensor is in good thermal communication of the heated air of the temperature-varying surface.3) The device of claim 1 , where the thermal insulation in the form of two concentric tubes made of a high temperature thermoplastic claim 1 , and each concentric tube can be moved with respect to the other to form a continuous thermal insulation layer over the inner-most heater tube.4) The device of where the active temperature-varying element to heat the temperature-varying surface is a resistive heating element.5) A device suitable for use to heat or cool a capillary tube and fittings in a liquid chromatography system at least one metallic temperature-varying plate that can be placed in good thermal contact with at least a part of the capillary column or the entire capillary column and its fittings;', 'at least one active temperature- ...

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Номер записи: 6
20-06-2013 дата публикации

Gas Chromatograph Column Markings to Determine Length

Номер: US20130152666A1
Автор: Scott T. Quarmby
Принадлежит: Thermo Finnigan LLC

A gas chromatograph column is marked with a code that allows an operator or machine to accurately determine the distance between two points on the column by comparing markings at the two points on the column. The code may be human or machine readable.

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Номер записи: 7
29-08-2013 дата публикации

Miniature hplc device

Номер: US20130219999A1
Автор: Ali Salehi-Reyhani, Duncan Robert Casey, Joseph John Kaplinsky
Принадлежит: IMPERIAL INNOVATIONS LTD

A liquid chromatography device comprises one or more liquid reservoirs ( 3 ) for a liquid medium, a sample reservoir for a sample to be analysed and a chromatography column ( 4 ) in fluid communication with the liquid reservoir ( 3 ) and the sample reservoir ( 5 ). The device further comprises a gas reservoir ( 1 ) for containing a volume of gas under pressure to force liquid from the liquid reservoir ( 3 ) through the chromatography column ( 4 ), in use.

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Номер записи: 8
24-10-2013 дата публикации

COLUMN OVEN FOR LIQUID CHROMATOGRAPH

Номер: US20130277350A1
Автор: Arima Yoshinori
Принадлежит: SHIMADZU CORPORATION

A column oven for a liquid chromatograph includes a temperature control mechanism possessing a heater, which controls a temperature, and a thermally conductive column holding member in contact with the temperature control mechanism for holding an analytical column of a liquid chromatograph and for transferring heat from the temperature control mechanism to the analytical column. The column holding member includes a space for containing the analytical column. The space is formed to have an opening on one side surface of the column holding member and to have a cross-sectional shape forming a part of an involute curve along a vertical direction with respect to a longitudinal direction of the analytical column held in the column holding member. 1. A column oven for a liquid chromatograph , comprising:a temperature control mechanism possessing a heater, the temperature control mechanism controlling a temperature by the heater; anda thermally conductive column holding member for holding an analytical column of a liquid chromatograph and for transferring heat from the temperature control mechanism to the analytical column,the column holding member being arranged in contact with the temperature control mechanism, andthe column holding member including a space for containing the analytical column, the space being formed to have an opening on one side surface of the column holding member and to have a cross-sectional shape forming a part of an involute curve along a vertical direction with respect to a longitudinal direction of the analytical column held in the column holding member.2. The column oven according to claim 1 , wherein the cross-sectional shape of the column holding member is uniform from an upstream end to a downstream end in a flow direction of the analytical column.3. The column oven according to claim 2 , wherein the cross-sectional shape of the column holding member has a recess that is curved to below a bottom end of the opening claim 2 , and is formed so ...

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Номер записи: 9
26-12-2013 дата публикации

Pressure Monitor Optimizaiton Of Fluid Path Utilization

Номер: US20130340503A1
Автор: James E. Usowicz, Peyton C. Beals, Russell Keene, Theodore D. Ciolkosz
Принадлежит: Waters Technologies Corp

A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible failing components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system.

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Номер записи: 10
09-01-2014 дата публикации

Fluid Switching Valve

Номер: US20140007660A1
Автор: Ciolkosz Theodore D., Moeller Mark W.
Принадлежит: WATERS TECHNOLOGIES CORPORATION

A fluid switching valve includes a first valve element (e.g., a stator) that has a plurality of first fluid-conveying features (e.g., ports), and a second valve element (e.g., a rotor) that has one or more second fluid-conveying features (e.g., fluid conduits in the form of grooves). The second valve element is movable, relative to the first valve element, between a plurality of discrete positions such that, in each of the discrete positions, at least one of the one or more second fluid-conveying features overlaps with multiple ones of the first fluid conveying features to provide for fluid communication therebetween. At least one of the first valve element and the second valve element includes a recess. The recess serves to reduce wear between the first valve element and the second valve element. The recess is arranged such that it does not overlap with any of the first fluid-conveying features or any of the second fluid-conveying features when the rotor is in any of the discrete positions. 1. A fluid switching valve comprising:a first valve element having a plurality of first fluid-conveying features;a second valve element having one or more second fluid-conveying features,wherein the second valve element is movable, relative to the first valve element, between a plurality of discrete positions such that, in each of the discrete positions, at least one of the one or more second fluid-conveying features overlaps with multiple ones of the first fluid conveying features to provide for fluid communication therebetween, andwherein at least one of the first valve element and the second valve element includes a recess, the recess serving to reduce wear between the first valve element and the second valve element and arranged such that it does not overlap with any of the first fluid-conveying features or any of the second fluid-conveying features when the rotor is in any of the discrete positions.2. The fluid switching valve of claim 1 , wherein the recess is positioned ...

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Номер записи: 11
06-03-2014 дата публикации

LIQUID SENDING PIPE FOR LIQUID CHROMATOGRAPH DETECTOR AND LIQUID CHROMATOGRAPH

Номер: US20140060163A1
Автор: GUNJI Masahide, WATANABE Masato
Принадлежит: SHIMADZU CORPORATION

A heat insulating member is provided on the outer circumference of a connection pipe . The heat insulating member includes: a tube ; and an air layer between the connection pipe and the tube . Accordingly, it is possible to always keep the temperature of a sample component at the time of detection by a detector constant and thus prevent an influence of the temperature on an output result of the detector, in a low flow rate analysis using a modularized column unit and a modularized detection unit. 1. A liquid sending pipe for a liquid chromatograph detector , the liquid sending pipe being used for a liquid chromatograph including: a column module in which a column is housed in a temperature-regulated constant temperature bath; and a temperature-regulated detection unit module , the liquid sending pipe comprising:a) a connection pipe provided between the constant temperature bath and the detection unit module; andb) a heat insulating member for covering an outer circumference of the connection pipe.2. The liquid sending pipe for a liquid chromatograph detector according to claim 1 , wherein the heat insulating member includes: an air layer for covering the outer circumference of the connection pipe; and a tube for covering the air layer.3. The liquid sending pipe for a liquid chromatograph detector according to claim 2 , wherein the heat insulating member includes a sealing member for sealing the air layer between the connection pipe and the tube.4. The liquid sending pipe for a liquid chromatograph detector according to claim 2 , wherein the heat insulating member includes a sponge for covering an outer circumference of the tube.5. The liquid sending pipe for a liquid chromatograph detector according to claim 3 , wherein the heat insulating member includes a sponge for covering an outer circumference of the tube.6. A liquid chromatograph including: a column module in which a column is housed in a temperature-regulated constant temperature bath; and a temperature- ...

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Номер записи: 12
06-03-2014 дата публикации

Gas chromatograph data processing device, recording medium recording data processing program, and data processing method

Номер: US20140067304A1
Автор: Tomohiro Sasaki
Принадлежит: Horiba Stec Co Ltd

Provided in order to permit accurate calculation of an adjusted retention time of alkane at a arbitrary temperature and thus permit more improvement in accuracy in calculation of a retention index at the arbitrary temperature based on a known retention index is a column inlet pressure setting part which receives at least a second sample temperature and outputs a second column inlet pressure such that a void time as a retention time of a non-retained substance as a substance not retained in a column at the second sample temperature becomes substantially equal to a void time at a first sample temperature.

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Номер записи: 13
20-03-2014 дата публикации

Adaptive Temperature Controller

Номер: US20140076885A1
Автор: Cai Huamin, Cowles Chris S., Stearns Stanley D.
Принадлежит: VALCO INSTRUMENTS COMPANY, L.P.

The adaptive temperature controller system includes a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at one or more temperatures and therefore determines the resistance of the material through a range of operating temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its temperature, are known. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature. 1. An adaptive temperature controller system for chromatographic analysis to control and maintain the temperature of a chromatographic column assembly during heating of said chromatographic column assembly , comprising:said chromatographic column assembly including a circular coil of a fused silica chromatographic column and a metal wire, said fused silica chromatographic column and said metal wire maintained adjacent within said coil, said coil wrapped in a heat conductive outer jacket; and device for measuring resistance,', 'said device for measuring resistance recording measurement of two members of the group consisting of power, current and voltage through said metal wire;', "said device for measuring resistance determining resistance of said metal wire by application of Ohm's Law to said two members of the group consisting of power, current and voltage;"], 'an adaptive temperature controller having'} 'said device for determining responsiveness of resistance determining the change in said resistance of said metal wire relative to change in said two members of the group consisting of power, current and voltage;', 'a device for determining responsiveness of resistance,'} said power supply in electrical communication with said metal wire;', 'said metal wire altering temperature based on said electrical communication from said power supply; and, 'a ...

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Номер записи: 14
27-03-2014 дата публикации

FLUID INTERFACE BETWEEN FLUID LINES OF DIFFERING CROSS-SECTIONAL AREA

Номер: US20140083173A1
Автор: Rapp Holger
Принадлежит:

A fluid transfer device transfers a fluid from a first fluid channel with a first cross-sectional area into a second fluid channel with a second cross-sectional area, larger than the first cross-sectional area. The fluid transfer device includes a fluid inlet interface at which the fluid is transferable from the first fluid channel into the fluid transfer device; an inlet branch configured to split the fluid from the first fluid channel into multiple inlet branch channels; multiple outlet branches, each of which is configured to split the fluid from the inlet branch channels into respective outlet branch channels; and a fluid outlet interface configured to transfer the fluid in the outlet branch channels into the second fluid channel. The inlet and output branches and branch channels are disposed such that the fluid exits from the fluid outlet interface, distributed in a two-dimensional manner across the second cross-sectional area. 1. A fluid transfer device for transferring a fluid from a first fluid channel with a first cross-sectional area at an outlet side into a second fluid channel with a second cross-sectional area at an inlet side , the second cross-sectional area being larger than the first cross-sectional area , the fluid transfer device comprising:a fluid inlet interface at which the fluid is transferable out of the first fluid channel into the fluid transfer device;an inlet branch fluidically coupled with the fluid inlet interface, and configured to split the fluid from the first fluid channel into a plurality of inlet branch channels;a plurality of outlet branches fluidically coupled with the inlet branch channels, wherein each of the outlet branches is configured to split the fluid from the inlet branch channels into a respective plurality of outlet branch channels; anda fluid outlet interface fluidically coupled with the outlet branch channels, and configured to transfer the fluid in the outlet branch channels into the second fluid channel,wherein ...

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Номер записи: 15
01-01-2015 дата публикации

Fluidic Chip with Displacable Patterned Layer for Detecting Fluid Pressure

Номер: US20150000416A1
Автор: Baeuerle Martin, Choikhet Konstantin
Принадлежит: AGILENT TECHNOLOGIES, INC.

A fluidic chip device configured for processing a fluid, wherein the fluidic chip device comprises a plurality of layers laminated to one another, wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure, and a pressure detector responding to the displacement of the patterned section by generating a detector signal being indicative of a value of the pressure. 1. A fluidic chip device configured for processing a fluid , the fluidic chip device comprising:a plurality of layers laminated to one another;wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure; anda pressure detector configured for responding to the displacement of the patterned section by generating a detector signal being indicative of a value of the pressure.2. The fluidic chip device according to claim 1 , comprising:a further patterned section of an alternating sequence of further bars and further fluidic channels for conducting a further fluid under pressure, wherein the further patterned section is configured for being displaceable in response to the pressure of the further fluid;wherein the pressure detector is configured for responding to the displacement of the further patterned section by generating a further detector signal being indicative of a value of the pressure of the further fluid; anda differential pressure determining unit configured for determining information related to a pressure difference between the fluid and the further fluid based on the detector signal and based on the further detector signal.3. The fluidic chip device according to claim 2 , wherein the further patterned section is ...

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Номер записи: 16
07-01-2016 дата публикации

Mobile Phase Degassing for Nano-Flow Liquid Chromatography

Номер: US20160001198A1
Автор: Petritis Konstantinos, Tegeler Tony
Принадлежит: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE

Systems and methods for degassing liquids in nano-flow liquid applications (). In a chromatography embodiment, a system includes a buffer container, a degasser, a buffer pump, a nano-flow pump, and a separation column. The buffer pump is configured to move a buffer from the buffer container through the degasser and the nano-flow pump is configured to move the buffer from the buffer container or the degasser to the separation column. 1. A nano-flow liquid chromatography system , comprising:a buffer container,a degasser in fluid communication with the buffer container,a buffer pump configured to move a buffer from the buffer container through the degasser,a nano-flow pump in fluid communication with at least one of the buffer container and the degasser; anda separation column in fluid communication with the nano-flow pump, wherein the nano-flow pump is configured to move the buffer from one of the buffer container and the degasser to the separation column.2. The nano-flow liquid chromatography system of claim 1 , wherein the buffer pump is configured to move the buffer from the buffer container claim 1 , through the degasser claim 1 , and back into the buffer container.3. The nano-flow liquid chromatography system of and further comprising a tee connection positioned at an outlet of the degasser claim 1 , wherein the tee connection is configured to direct a first portion of the buffer from the degasser toward the buffer container and a second portion of the buffer from the degasser toward the nano-flow pump.4. The nano-flow liquid chromatography system of and further comprising a tee connection positioned at an outlet of the degasser claim 1 , and a waste container in fluid communication with the degasser claim 1 , wherein the tee connection is configured to direct a first portion of the buffer from the degasser toward the waste container and a second portion of the buffer from the degasser toward the nano-flow pump.5. A nano-flow liquid degassing system claim 1 , ...

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Номер записи: 17
04-01-2018 дата публикации

Novel multimodal oscillatory chromatographic purification system

Номер: US20180001227A1
Автор: Michael Dale Hilgert
Принадлежит: Individual

The present invention comprises a novel multimodal chromatography sequence of short length alternating adsorption and size exclusion media operating with gradient elution. The novel multimodal chromatography in an oscillating series utilizes the alternating solvent exchange media to reposition the active region of separation back in phase with the target solutes. Each solvent exchange column bed length in the sequence is designed to achieve a subtle decrease or increase in the solvent gradient (or salt gradient) concentration associated with the two solutes of interest which results in an extension of the active separation or increasing differences in solute velocity for two solutes of interest. The novel oscillatory chronographic system demonstrates much improved separation capability as shown by a one dimensional model.

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Номер записи: 18
02-01-2020 дата публикации

PORTABLE GAS ANALYSIS DEVICE WITH COMPACT MEASUREMENT DEVICE

Номер: US20200003738A1
Автор: Jünemann Arne, SCHMITTMANN Matthias, Weber Johannes, Weber Paul
Принадлежит: bentekk GmbH

A portable gas analysis device having a separating column and a detector. The separating column is composed as a multi-capillary unit from parallel individual capillaries and, depending on the length, is bent into a compact shape, preferably even wound into multiple turns. A thermally conductive casing and a thermal stabilizing device are provided for the multi-capillary unit. The thermal stabilizing device comprises a temperature sensor, a heating element and control electronics. The casing protects the sensitive multi-capillary unit from mechanical actions; it acts as a protective space. The temperature-controlled casing also forms a space in which uniform and controlled conditions prevail and which in particular is isolated from the temperature and humidity of the environment, allowing reliable measurements outside a laboratory environment, in the field. This double effect of the casing for the capillaries in conjunction with the compact dimensions forms the true essence of the invention. 1. A portable gas analysis device comprising a measuring unit that comprises:a detector;a separation column embodied as a multi-capillary unit that comprises capillaries arranged in parallel in bent form;a casing for the multi-capillary unit, the casing comprising a material having good thermal conductivity; anda thermal stabilization unit that comprises a temperature sensor and a heating element located on the casing.2. The portable gas analysis device of claim 1 , wherein the multi-capillary unit comprises capillaries wound in multiple turns.3. The portable gas analysis device of claim 1 , wherein multiple heating elements are arranged on the casing such that the multi-capillary unit is temperature-controlled homogeneously.4. The portable gas analysis device of claim 1 , wherein the multi-capillary unit is anchored using a heat-conductive holder in the casing.5. The portable gas analysis device of claim 1 , wherein the casing encloses the multi-capillary unit in a ring shape ...

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Номер записи: 19
07-01-2021 дата публикации

An improved thermal modulator

Номер: US20210003539A1
Автор: Carson William W., Crotti Alberto, Saini Massimiliano, Taschini Roberto
Принадлежит:

A thermal modulator for gas chromatography includes an analytical capillary to be traversed by analytes and that is interposed between two gas chromatographic columns; a cooling system having a cold zone, a support element associated with the cold zone and supporting a portion of the analytical capillary at a corresponding or slightly higher temperature than the cold zone, so as to define a trapping portion of the analytes; a control system, which selectively controls the emission of pulsed current to electrically conductive elements associated with the analytical capillary to heat the trapping portion and cause the release or desorption of previously immobilized analytes; and a heating system of a portion of the analytical capillary, positioned outside of the support element and upstream of the support element, so as to generate a rapid expansion of the gas contained in the portion and facilitate the advancement of the released or desorbed analytes. 146.-. (canceled)47. A thermal modulator for gas chromatography comprising:an analytical capillary for crossing analytes and adapted to be interposed between two gas chromatographic columns;a cooling system comprising a cold zone;a support element associated with the cold zone and configured to support a first portion of the analytical capillary so that the first portion is at a same or than the cold zone, the first portion passing through or is in contact with the support element defining a trapping portion in which the analytes passing through the analytical capillary are to be trapped or immobilized;a control system that selectively controls a sending of pulsed current to electrically conductive elements associated with the analytical capillary, so as to heat the trapping portion and cause a release or desorption of previously immobilized analytes; anda heating system that causes a heating of a second portion of the analytical capillary positioned outside of the support element and upstream of the first portion of ...

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Номер записи: 20
07-01-2021 дата публикации

Continuous Backpressure Monitoring to Determine the System Health State of HPLC Systems

Номер: US20210003540A1
Автор: Rendl Martin
Принадлежит:

A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times. 1. A method for determining a state of a fluidic system , the method comprising:measuring back pressures in the fluidic system at different times; anddetermining the state of the fluidic system, wherein the determining the state is based on at least the measured back pressures.2. The method according to claim 1 , wherein the determining the state is also based on an additional status information at at least one of the different times claim 1 , andwherein the determining the state of the fluidic system comprises: comparing the measured back pressures to at least one reference.3. The method according to claim 2 , wherein the at least one reference is based on the back pressures measured under conditions which are at least comparable to conditions at the different times.4. The method according to claim 2 , wherein the reference used in the comparing the measured back pressure depends on the additional status information.5. The method according to claim 1 , wherein the determining the state of the fluidic system further comprises:determining a deviation when an absolute value between one of the measured back pressure and at least one reference exceeds a threshold.6. The method according to claim 5 , wherein the fluidic system comprises a pump configured to generate a liquid flow claim 5 ,wherein the fluidic system is configured to include different configurations,wherein the configurations differ at least as regards which components are fluidly connected to the pump; 'the fluidic system assuming a second configuration, which is different from the first configuration, and determining whether the ...

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Номер записи: 21
07-01-2021 дата публикации

LIQUID CHROMATOGRAPHY SYSTEMS

Номер: US20210003541A1
Автор: Sievers-Engler Adrian
Принадлежит: ROCHE DIAGNOSTICS OPERATIONS, INC.

A liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream, the fluidic stream comprising a sample-injection valve, a trap-bypass-selection valve, a column-bypass valve, a load-elute valve and a trap-selection valve. Also, a liquid chromatographic (LC) system is introduced which comprises at least one fluidic stream. The fluidic stream comprises a first substream and a second substream. The first substream comprises a first sample-injection valve, a load-elute valve and a trap-selection valve. The second substream comprises a second sample-injection valve and a column-bypass valve. The fluidic stream further comprises a trap-LC substream transfer valve and a substream-selection valve. The LC systems provide a broad choice of chromatographic options and modes and enable to flexibly and rapidly switch between them. 1. A liquid chromatographic (LC) system comprising at least one fluidic stream , the fluidic stream comprising:a sample-injection valve comprising a plurality of ports and a multi-way switch to switch fluidic connections between ports, including a sample input port fluidically connected to a sample input nozzle, an aspiration/dispensing-pump port fluidically connected to a sample aspiration pump, a sample-loop-input port and a sample-loop-output port interconnected by a sample loop, an LC-pump port fluidically connected to an LC pump and a sample-injection-to-trap-bypass-selection port;a trap-bypass-selection valve comprising a plurality of ports and a multi-way switch to switch fluidic connections between ports, including a trap-bypass-selection-to-sample-injection port fluidically connected to the sample-injection-to-trap-bypass-selection port of the sample injection valve, two bypass ports interconnected by a bypass fluidic path, a trap-bypass-selection-to-column-bypass port and two trap-bypass-selection-to-load-elute ports;a column-bypass valve comprising a plurality of ports and a multi-way switch to switch fluidic ...

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Номер записи: 22
03-01-2019 дата публикации

MODULAR AUTOMATED CHROMATOGRAPHY SYSTEM

Номер: US20190004017A1
Автор: AVARBOCK Bob, BAKER Ken, Bland Wayne, GORDON Alec, Iovanni Robert, MAVANDADI Farah, Price Glenn, SCHULTZ Christof
Принадлежит:

Valves, pumps, detectors, sample loops, fraction collectors and the like are individually incorporated into modules that are mountable at individual mounting sites on a base unit which also supports one or more chromatography columns. Each module includes fluid connections to other modules and a microcontroller joining the module to a computed and monitor through an electronic connector at each mounting site. The fluid connections between the modules and the column(s) are removed from the electronic connections and accessible to the user. A software platform may recognize the modules and their locations, coordinate fluid connections between the modules, and provide a variety of control, monitoring, data generating and data processing functions to generate chromatographic data. The software platform may also provide graphical tools for designing chromatographic methods from a library of phases. 1. A system for joining a plurality of fluid manipulation components into a flow scheme for directing fluids to and from a chromatographic separation device and for operating said joined fluid manipulation components according to a selected protocol , said system comprising:a plurality of modules, each said module comprising (a) one of said fluid manipulation components, and (b) a microcontroller that transmits operational signals to said fluid manipulation component in response to commands received from outside said module;a mounting frame comprising a plurality of bays, each of the plurality of bays constructed to receive a single module, and each of the plurality of bays comprising a signal connector that couples to and communicates with the microcontroller of a module mounted in said bay, wherein at least some of the bays are constructed to receive single modules interchangeably with other said modules; anda software platform in communication with the microcontroller of each module, said software being programmed to (1) receive from each of the plurality of modules ...

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Номер записи: 23
03-01-2019 дата публикации

MODULAR AUTOMATED CHROMATOGRAPHY SYSTEM

Номер: US20190004018A1
Автор: AVARBOCK Bob, BAKER Ken, Bland Wayne, GORDON Alec, Iovanni Robert, MAVANDADI Farah, Price Glenn, SCHULTZ Christof
Принадлежит:

Valves, pumps, detectors, sample loops, fraction collectors and the like are individually incorporated into modules that are mountable at individual mounting sites on a base unit which also supports one or more chromatography columns. Each module includes fluid connections to other modules and a microcontroller joining the module to a computed and monitor through an electronic connector at each mounting site. The fluid connections between the modules and the column(s) are removed from the electronic connections and accessible to the user. A software platform may recognize the modules and their locations, coordinate fluid connections between the modules, and provide a variety of control, monitoring, data generating and data processing functions to generate chromatographic data. The software platform may also provide graphical tools for designing chromatographic methods from a library of phases. 1. A system for configuring and operating a plurality of fluid manipulation components joined into a flow scheme for directing fluids to and from a chromatographic separation device , the system comprising:a plurality of modules, each of the plurality of modules comprising (a) one of the fluid manipulation components, and (b) a microcontroller that transmits operational signals to the fluid manipulation component in response to commands received from outside the module;a mounting frame comprising a plurality of bays, each of the plurality of bays constructed to receive a single module, and each of the plurality of bays comprising a signal connector that couples to and communicates with the microcontroller of a module mounted in the bay, wherein at least some of the bays are constructed to receive single modules interchangeably with other modules; anda software platform in communication with the microcontroller of each module, the software platform having a user interface configured to:display a library of descriptions of phases usable in a chromatography process; andenable a ...

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Номер записи: 24
13-01-2022 дата публикации

CARRIER GAS CONNECTION DEVICE FOR GAS CHROMATOGRAPHS

Номер: US20220011279A1
Автор: CHU Bo
Принадлежит:

Carrier gas connection devices () enable one to change the carrier gas provided to a gas chromatography channel. The carrier gas connection devices () comprise a channel adaptor (), a carrier block (), and a clamping system, and two or more channel adaptor positions. In each of the channel adaptor positions, a fluid-tight flow path for carrier gas out of the carrier block () into the channel adaptor () is formed. Carrier gas distribution systems (), gas chromatography instruments, and methods of changing a carrier gas supplied to a GC are also provided. 1. A carrier gas connection device comprising:a carrier block comprising first and second carrier block carrier gas passageways, and each of the carrier block carrier gas passageways comprises an entrance and exit;a channel adaptor comprising a channel adaptor carrier gas passageway having an entrance and an exit;a clamping system that fastens the carrier block to the channel adaptor in a substantially fluid-tight connection; andthe carrier gas connection device comprises first and second channel adaptor positions wherein:(i) in the first channel adaptor position, the channel adaptor carrier gas passageway entrance aligns with the first carrier block carrier gas passageway exit to form a fluid-tight flow path for a first carrier gas out of the carrier block into the channel adaptor, and(ii) in the second channel adaptor position, the channel adaptor carrier gas passageway entrance aligns with the second carrier block carrier gas passageway exit to form a fluid-tight flow path for a second carrier gas out of the carrier block into the channel adaptor.2. The carrier gas connection device of claim 1 , wherein the channel adaptor is configured for switching from one of the channel adaptor positions to another of the channel adaptor positions by manual movement.3. The carrier gas connection device of claim 1 , wherein the channel adaptor comprises one or more sealing surfaces configured to form a fluid-tight plug of one ...

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Номер записи: 25
08-01-2015 дата публикации

Intake profile for optimized utilization of motor characteristics

Номер: US20150008862A1
Автор: Joshua A. Shreve, Steven J. Ciavarini
Принадлежит: Waters Technologies Corp

Systems and methods for operating a stepper motor of a pump at a desired low velocity include memory for storing information corresponding to an intake velocity profile. The intake velocity profile represents an optimized acceleration curve for operating the stepper motor over a range of motor velocities during an intake cycle. A processor of a system controller dynamically accesses the memory during the intake cycle to acquire the information representing the intake velocity profile and issues a series of pulses to the stepper motor based on this information. In response to the pulses, the stepper motor accelerates in accordance with the optimized acceleration curve represented by the intake velocity profile. The optimized acceleration curve is based on the available torque of the stepper motor across a range of motor velocities and enables the motor to operate with greater torque utilization and less margin than traditional linear acceleration profiles.

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Номер записи: 26
11-01-2018 дата публикации

System for Blending Solutions

Номер: US20180008907A1
Автор: Olovsson Bjorn Markus
Принадлежит:

A system for blending solutions and a buffer solution is disclosed. In this system a switch valve is present capable of flowing one or more solutions, a low pressure pump for pumping the one or more solutions through the switch valve and a T-joint capable of receiving the one or more solutions through the low pressure pump and blending the one or more solutions with a buffer solution. A high pressure pump is present for collecting a blended solution. 1. A system for blending solutions , the system comprising:a switch valve capable of flowing at least one solution;a low pressure pump for pumping the at least one solution through the switch valve;a T-joint placed between the low pressure pump and high pressure pump, the T-joint capable of receiving the at least one solution through the low pressure pump and blending the at least one solution with a buffer solution; anda high pressure pump for collecting a blended solution.2. The system of claim 1 , wherein the T-joint is connected to a container holding the buffer solution through at least one direct connection.3. The system of claim 2 , wherein the switch valve is capable of allowing the buffer solution to flow from the container claim 2 , the low pressure pump enable pumping of the buffer solution through the switch valve.4. The system of claim 1 , wherein the at least one solution comprises at least one of an acid claim 1 , a base and a salt solution.5. The system of claim 1 , further comprising a control system configured to: control operation of the low pressure pump for supplying the at least one solution and control the functioning of the switch valve capable of flowing the at least one solution.6. The system of claim 5 , wherein the control system is configured to control the flow rate of the at least one solution supplied by the at least one low pressure pump claim 5 , the flow rate of the at least one solution determines concentration of the blended solution.7. The system of claim 1 , further comprising at ...

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Номер записи: 27
27-01-2022 дата публикации

AUTO-SAMPLER FOR CHROMATOGRAPHS

Номер: US20220026400A1
Автор: ANDO Shotaro, Inoue Takashi, Yasunaga Kenichi
Принадлежит: SHIMADZU CORPORATION

The auto-sampler for chromatographs includes a sampling needle, a pipe, a pump portion, and a connecting mechanism configured to connect the sampling needle and the pipe. The connecting mechanism includes a first component fixed to the sampling needle, a second component fixed to the pipe, a fixing component, and a packing. The fixing component fixes the first component and the second component using screwing of screws while the end surface of the sampling needle and the end surface of the pipe are in contact with the packing. As a result, dead volume at the connecting portion between the sampling needle and the pipe is reduced. 19-. (canceled)10. A chromatograph comprising:a sampling needle having a tip end and a base end, the sampling needle being configured to suck sample through the tip end;a pipe in fluid connection with the base end of the sampling needle; anda connecting mechanism configured to fluidically connect the sampling needle and the pipe, the connecting mechanism including a first component fixed to one of the sampling needle and the pipe, a second component fixed to the other of the sampling needle and the pipe, and a fixing component configured to fix the first component and the second component using screwing of screws, whereinthe first component includes a first seal surface on which an end surface of said one of the sampling needle and the pipe protrudes from or is disposed on the same plane of the first seal surface,the second component includes a second seal surface facing the first seal surface, an end surface of said other of the sampling needle and the pipe protrudes from or is disposed within the same plane of the second seal surface, andthe connecting mechanism includes a packing interposed between the first seal surface of the first component and the second seal surface of the second component, and the connecting mechanism fixes the first component and the second component by using the fixing component while the end surface of the ...

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Номер записи: 28
27-01-2022 дата публикации

GAS CHROMATOGRAPH, MAINTENANCE SWITCH MODE SETTING METHOD AND NON-TRANSITORY COMPUTER READABLE MEDIUM STORING MAINTENANCE SWITCH MODE SETTING PROGRAM

Номер: US20220026402A1
Автор: KOMORI Yuki
Принадлежит: SHIMADZU CORPORATION

A gas chromatograph includes first and second sample vaporization units, first and second separation columns, first and second carrier gas suppliers, a column oven that contains the first and second separation columns and has a first heater, first and second detectors, a first auxiliary gas supplier that supplies an auxiliary gas to the first separation column and a controller that executes control by increasing a supply pressure of an auxiliary gas applied by the first auxiliary gas supplier to a pressure higher than a pressure during an analysis of a sample and lowering a supply pressure of a carrier gas applied by the first carrier gas supplier to a pressure lower than a pressure during the analysis of the sample such that the supply pressure of the auxiliary gas is higher than the supply pressure of the carrier gas, and sets a first maintenance switch mode in which the first sample vaporization unit is maintainable. 1. A gas chromatograph comprising:a first sample vaporization unit that vaporizes a sample;a second sample vaporization unit that vaporizes a sample;a first separation column that separates a sample supplied from the first sample vaporization unit into respective sample components;a second separation column that separates a sample supplied from the second sample vaporization unit into respective sample components;a first carrier gas supplier that supplies a carrier gas, for guiding a sample that is vaporized in the first sample vaporization unit to the first separation column, to the first sample vaporization unit;a second carrier gas supplier that supplies a carrier gas, for guiding a sample that is vaporized in the second sample vaporization unit to the second separation column, to the second sample vaporization unit;a column oven that contains the first and second separation columns and has a first heater for heating the first and second separation columns;a first detector that detects respective sample components obtained by separation in the ...

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Номер записи: 29
14-01-2016 дата публикации

Apparatus for Field-Flow Fractionation

Номер: US20160011155A1
Автор: Klein Thorsten
Принадлежит:

The present invention relates to an apparatus for field-flow fractionation and to a method for separating samples by means of field-flow fractionation using this apparatus. The apparatuses of the invention comprise one or more reservoirs, a pump, a first flow volume splitting device, two valves for flow control, an injector, a separation channel having a first connector at a first end and a second connector at a second end or an AF4 separation channel having a first connector at a first end, a second connector at a second end and a third connector between the first and the second ends, optionally a second flow volume splitting device, a back-pressure element, one or more detector(s), a flow volume control device and one or more waste container(s). The apparatuses of the invention are characterized in that they comprise a valve for flow control in a first flow path and a second flow path which connect the pump to the first or the second or the third connector of the separation channel and that these valves are switched alternately in a controllable time ratio. 1. An apparatus for field-flow fractionation , comprising one or more reservoirs , a pump , a first flow volume splitting device , a first valve , an injector , a separation channel with a first connector at a first end and a second connector at a second end , a second flow volume splitting device , a second valve , a back-pressure element , one or more detectors , a flow volume control device and one or more waste containers , whereinthe first flow volume splitting device is suitable to split the volume flow generated by the pump into a first flow path connecting the pump to the first connector of the separation channel and a second flow path connecting the pump to the second connector of the separation channel,the injector is arranged in the first flow path,the second flow volume splitting device is arranged within the second flow path and is suitable to split the volume flow of the second flow path between ...

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Номер записи: 30
10-01-2019 дата публикации

METHOD OF PUMP OPERATION, USE OF THE METHOD IN HPLC, PUMP, PUMP SYSTEM, AND HPLC SYSTEM

Номер: US20190010940A1
Автор: HAECKEL Michael, Seitz Stefan, STROBL Christoph
Принадлежит:

The present invention relates to a method of operating a pump generating a flow of a fluid with a pressure, the method comprising operating the pump with a pump speed S satisfying the equation S=S(1+COR(t)); wherein S is the pump speed, Sis the pump speed disregarding any compression and/or expansion of the fluid, t is a time, and COR(t) is a time dependent correction function; wherein the time dependent correction function COR(t) is a product of a corrective amplitude Aand a time-dependent function f(t), i.e., COR(t)=A·f (t); and wherein the corrective amplitude Ais set by means of a measure for the flow and a measure for the pressure. The present invention also relates to a corresponding use, a pump, a pump system and an HPLC system. 1. A method of operating a pump generating a flow of a fluid with a pressure , the method comprising: {'br': None, 'i': S=S', '+COR', 't, 'sub': 'simple', '(1());'}, 'operating the pump with a pump speed S satisfying the equation'}{'sub': 'simple', 'wherein S is the pump speed, Sis the pump speed without correcting for a compression or an expansion of the fluid, t is a time, and COR(t) is a time dependent correction function;'}{'sub': 'cor', 'wherein the time dependent correction function COR(t) comprises a product of a corrective amplitude Aand a time dependent function f(t); the method further comprising{'sub': 'cor', 'calculating the corrective amplitude Abased on a measure of the flow of the fluid and a measure of the pressure of the fluid.'}2. The method of claim 1 , wherein the calculating the corrective amplitude Ais based on a quotient of the measure of the pressure and the measure of the flow.3. The method of claim 1 , wherein the corrective amplitude Ais proportional to the measure of the pressure and is inversely proportional to the measure of the flow.5. The method further comprising:flowing the fluid at a test flow and at a test pressure, wherein the test flow ranges from 1 μl/min to 10000 μl/min and the test pressure ...

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Номер записи: 31
14-01-2021 дата публикации

ANALYZER

Номер: US20210010982A1
Автор: Takahashi Kazunori
Принадлежит:

An analyzer capable of suppressing the generation of noise in a current detection circuit is provided. On a board , a current detection circuit for processing an output signal from a detector is mounted. The cover member has a space in which the current detection circuit is accommodated. A gas is supplied from a gas source into the space . The cover member is provided with an inlet port for introducing the gas from the gas source into the space and an outlet port for discharging the gas in the space 1. An analyzer comprising:a detector configured to detect components in a sample;a board on which a current detection circuit for processing an output signal from the detector is mounted;a cover member having a space in which a current detection circuit is accommodated; anda gas source configured to supply a gas to the space,wherein the cover member is provided with an inlet port for introducing the gas from the gas source into the space and an outlet port for allowing the gas in the space to flow out.2. The analyzer as recited in claim 1 , further comprising:a column to which a sample is supplied together with a carrier fluid,wherein the gas source is configured to supply the gas as the carrier fluid to the column.3. The analyzer as recited in claim 1 ,wherein the gas source is configured to supply the gas to the detector,4. The analyzer as recited in claim 1 , further comprising:a base member configured to hold the board,wherein the cover member is attached to the base member to cover the board and the current detection circuit mounted on the board.5. The analyzer as recited in claim 1 ,wherein the cover member is attached to the board to cover the current detection circuit.6. The analyzer as recited in claim 1 , further comprising:a Peltier element provided in the space to cool an electronic component included in the current detection circuit.7. The analyzer as recited in claim 1 ,wherein the gas is an inert gas.8. The analyzer as recited in claim 1 , further ...

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Номер записи: 32
15-01-2015 дата публикации

Process analytic device with improved thermal stability

Номер: US20150013430A1
Автор: Edward J. Bailey, Leighton M. Fields, Steven S. Black
Принадлежит: Rosemount Analytical Inc

A process analytic device includes an input to receive a sample of interest and an analytic detector operably coupled to receive the sample of interest. An analytic output is provided relative to the sample of interest. A plurality of heat pipes is thermally coupled to the analytic detector.

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Номер записи: 33
03-02-2022 дата публикации

SPIRAL WOUND PROTEIN SEPARATION DEVICE

Номер: US20220032209A1
Автор: Johnson Matthew A., McManaway Michael C., Zukor Kenneth A.
Принадлежит: W. L. Gore & Associates, Inc.

The present invention is directed to an affinity chromatography device that has a normal flow and which separates a targeted protein from aqueous mixtures. The chromatography device includes a housing containing therein a spiral wound membrane assembly that includes at least one inner intermediate material that forms an outer flow channel, at least one polymer membrane that contains therein inorganic particles, and at least one outer intermediate material that forms an inner flow channel sequentially positioned around a central core having a solid outer wall. An aqueous mixture is passed through the outer flow channel, through the polymer membrane where the targeted protein is removed, and then through an inner flow channel. The affinity chromatography device further includes an inlet flow distributor containing an inlet and an outlet flow distributer containing an outlet. Additionally, the chromatography device has a dimensionless resistance parameter that is less than 0.08. 1. An affinity chromatography device comprising:an exterior housing;an inlet flow distributor having therein an inlet to permit fluid flow into said housing and being located at a first end of said housing;a centrally located core; and [ 'wherein said at least one inner intermediate material includes an inner flow channel,', 'at least one inner intermediate material,'}, 'a polymer membrane having therein inorganic particles having a nominal particle size; and', wherein said at least one outer intermediate material includes an outer flow channel,', 'wherein said inner intermediate material, said polymer membrane, and, 'at least one outer intermediate material,'}, 'said outer intermediate material are positioned around said core; and, 'a wound membrane assembly disposed within said housing, said wound membrane assembly comprisinga flow distributor positioned at an opposing second end of said wound membrane assembly and having therein an outlet to permit fluid flow out of said housing,wherein said ...

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Номер записи: 34
03-02-2022 дата публикации

Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive joule thomson coefficient

Номер: US20220034555A1
Автор: Brian Jeffrey Waibel, Curtis Ebersold, Kenneth Joseph James, Kenneth Richard Krewson, Kim Ferrara
Принадлежит: SUPERCRITICAL FLUID TECHNOLOGIES Inc

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thomson coefficient.

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Номер записи: 35
15-01-2015 дата публикации

TEST APPARATUS FOR TESTING THE MICROBIAL ACTIVITY ON SURFACES

Номер: US20150017680A1
Автор: AL-Ahmad Ali, Lienkamp Karen, Nanko Norbert, Steinberg Thorsten
Принадлежит:

The present invention relates to a device comprising a sample receiving appliance, a receiving appliance for test organisms, preferably for a suspension comprising test organisms, in particular for a bacterial suspension, and a jet pump appliance, wherein the jet pump appliance is, or can be brought, into active connection with the receiving appliance, and wherein the jet pump appliance is designed and installed in order, by means of a propellant medium having a higher pressure than atmospheric pressure at the location of installation of the device to spray test organisms in the form of an aerosol in the direction of the sample receiving installation, wherein the device has an installation for controlling a reproducible pressure of the propellant medium during the spraying of the test organisms and also the use of a device according to the invention. 1. Device comprising a sample receiving appliance , a receiving device for test organisms , preferably for a suspension comprising test organisms , in particular for a bacterial suspension , and a jet pump appliance , wherein the jet pump appliance is , or can be brought , into active connection with the receiving appliance , and wherein the jet pump appliance is configured and adapted in order , by means of a propellant medium having a higher pressure than atmospheric pressure at the location of installation of the device , to spray test organisms in the form of an aerosol in the direction of the sample receiving appliance , characterized in thatthe device has an installation for controlling a reproducible pressure of the propellant medium during the spraying of the test organisms.2. Device according to claim 1 , characterized in thatthe installation for controlling a reproducible pressure of the propellant medium comprises a valve for regulation of the feeding of the fluid, and wherein preferably compressed air is provided by a compressed air means.32. Device according to oder claim 1 , characterized in thata ...

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Номер записи: 36
21-01-2016 дата публикации

THERMALLY MODULATED VARIABLE RESTRICTOR

Номер: US20160018366A1
Автор: Fogwill Michael O., Michienzi Joseph D., Murphy James P.
Принадлежит:

Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel. A restrictor tip, disposed adjacent the outlet of the fluidic channel, has an egress opening that is smaller than an internal diameter of the fluidic channel. A heating element, thermally coupled to a subsection of the fluidic channel between its inlet and outlet, heats the mobile phase passing through that subsection of the fluidic channel. The restriction produced by the restrictor tip in response to the heating of the mobile phase enables independent control of system pressure and linear velocity of the mobile phase within the column.

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Номер записи: 37
21-01-2016 дата публикации

MATCHING THERMALLY MODULATED VARIABLE RESTRICTORS TO CHROMATOGRAPHY SEPARATION COLUMNS

Номер: US20160018367A1
Автор: Fogwill Michael O., Gerhardt Geoff, Michienzi Joseph D., Murphy James P.
Принадлежит:

Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.

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Номер записи: 38
17-01-2019 дата публикации

UNIT FOR NON-CONTINUOUS SAMPLE FRACTIONATION AND INTEGRATION, AND DUAL ONLINE MULTIFUNCTIONAL LIQUID CHROMATOGRAPHY DEVICE HAVING SAME

Номер: US20190017974A1
Автор: LEE Hangyeore, Lee Sang-Won
Принадлежит: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Disclosed are non-continuous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-continuous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions. 1. A non-continuous sample fractionating and concatenating device , comprising:a sample supply module which supplies a sample to be analyzed; anda sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.2. The non-continuous sample fractionating and concatenating device according to claim 1 , wherein the sample fractionation module includes:a first fractionation valve connected to the sample supply module, into which the sample is introduced;a second fractionation valve provided adjacent to the first fractionation valve; anda ...

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Номер записи: 39
21-01-2021 дата публикации

DEVICE FOR CONTROLLING A PISTON PUMP UNIT FOR LIQUID CHROMATOGRAPHY

Номер: US20210017970A1
Автор: STROBL Christoph
Принадлежит: DIONEX SOFTRON GMBH

A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit. The fluctuations can occur as a result of the cooling of the liquid medium that is heated in an adiabatic manner during a pre-compression phase in the working piston. The control unit controls the piston speed of at least one piston-cylinder unit during the transition phase depending on at least one characteristic, which is ascertained from chronologically previously detected pressure values, such that variations of the system pressure as a result of the cooling of the adiabatically heated medium are at least partially compensated for. 1. A method to control a piston pump for liquid chromatography , the piston pump including at least two phase-offset cyclically working piston-cylinder units , which produce a predefined flow of a liquid medium to be delivered at an outlet port , wherein a constant system pressure results at the outlet port , the method comprising:in a pre-compression phase of one cycle of at least one of the piston-cylinder units, compressing a piston in the piston-cylinder unit;measuring a first pressure at a first time and a second pressure at a second time during the pre-compression phase in which an adiabatic heating effect is negligible in the piston-cylinder unit;extrapolating the first pressure at the first time and the second pressure at the second time to determine a calculated time in which the pressure of the piston-cylinder unit will be at the constant system pressure;determining a detected time in which the pressure of the piston-cylinder unit is measured with a pressure sensor to be at the constant system pressure;calculating a time difference based on the calculated time and the ...

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Номер записи: 40
16-01-2020 дата публикации

Automatic back-pressure valve for use in supercritical fluid chromatographic system

Номер: US20200018402A1
Автор: Jie Liu, Yan Zhang, Zhiling LI, ZHONG Yan
Принадлежит: Jiangsu Hanbon Science and Technology Co Ltd

An automatic back-pressure valve is for use in a supercritical fluid chromatographic system, consisting of: a spring support ( 1 ); an ejector rod spring ( 2 ); an ejector rod ( 3 ); a piston rod ( 4 ); a guide band ( 5 ); a cylinder body ( 6 ); an O-ring seal ring A ( 7 ); an O-ring seal ring B ( 8 ); a piston rod spring ( 9 ); a cylinder cover ( 10 ); a guide sleeve ( 11 ); a conical ceramic element ( 12 ); a seal ring ( 13 ); a sealing base ( 14 ); a valve body ( 15 ); a screw ( 16 ); and a positioning sleeve ( 17 ).

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Номер записи: 41
16-01-2020 дата публикации

GAS CHROMATOGRAPH

Номер: US20200018732A1
Автор: KOMORI Yuki, TAKECHI Ryo
Принадлежит: SHIMADZU CORPORATION

A gas chromatograph includes a sample introduction portion and a heater block. A contact portion is fit into a first recess of a main body of the sample introduction portion. The heater block is fixed to and positioned with respect to the main body of the sample introduction portion by directly coming into contact with the contact portion provided on the main body of the sample introduction portion. For this reason, the heater block may be surely positioned with respect to the sample introduction portion. In addition, the heater block may be positioned without providing a member such that heat from the heater block is transferred to the outside and lost, and thus the sample introduction portion may be efficiently heated. 1. A gas chromatograph comprising:a sample introduction portion in which a sample vaporization chamber for vaporizing a sample is formed;a heater block that heats the sample introduction portion from an outside; anda positioning mechanism that positions the heater block with respect to the sample introduction portion by bringing the heater block into contact with a contact portion provided on the sample introduction portion.2. The gas chromatograph according to claim 1 , wherein the heater block is a tubular member claim 1 ,the sample introduction portion is inserted into the heater block along an axis direction, andthe positioning mechanism positions the heater block with respect to the sample introduction portion while interposing both end portions of the heater block in the axis direction.3. The gas chromatograph according to claim 1 , wherein the positioning mechanism is allowed to change a relative position of positioning of the heater block with respect to the sample introduction portion.4. The gas chromatograph according to claim 3 , 'the positioning mechanism is allowed to change the relative position of positioning of the heater block with respect to the sample introduction portion by bringing the heater block into contact with the contact ...

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Номер записи: 42
21-01-2021 дата публикации

MIXING FLUID BY COMBINED AXIAL MOTION AND ROTATION OF MIXING BODY

Номер: US20210018475A1
Автор: Berndt Manfred, Plachetka Clemens, Shoykhet Konstantin
Принадлежит:

A mixer for mixing a mobile phase in a sample separation device for separating a fluidic sample, wherein the mixer includes a fluid inlet for supplying the mobile phase to be mixed to a mixing volume, a movable body configured for rotating and axially moving in the mixing volume to thereby mix the mobile phase, and a fluid outlet for supplying the mixed mobile phase to a mobile phase consumer. 1. A valve for mixing a mobile phase in a sample separation device for separating a fluidic sample , the valve comprising:a fluid inlet for supplying the mobile phase to be mixed to a mixing volume;a movable body configured to rotate and axially move in the mixing volume to thereby mix the mobile phase; anda fluid outlet for supplying the mixed mobile phase to a mobile phase consumer,wherein the movable body is configured as a valve body operable for selectively opening or closing a flow path of mobile phase through the fluid inlet, along the mixing volume and through the fluid outlet, and comprising at least one of the following features:wherein the valve body is configured to selectively open or close the flow path by being actuated by an axial movement;wherein the valve body is configured to be actuated by the mobile phase.2. The valve according to claim 1 , wherein the movable body comprises at least one of the following: a substantially rotationally symmetric body; a cylinder body; a disk body; and a combined cylinder-disk body.3. The valve according to claim 1 , wherein at least part of a surface of the movable body or a radial bearing surrounding the movable body and delimiting the mixing volume comprises a structured surface configured to promote mixing the mobile phase when interacting with the mobile phase.4. The valve according to claim 1 , wherein the movable body is at least partially made of a magnetic material so as to be rotatable and axially movable by a magnetic drive force.5. The valve according to claim 4 , wherein the magnetic material of the movable body ...

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Номер записи: 43
26-01-2017 дата публикации

Modular Multiple-Column Chromatography Cartridge

Номер: US20170023536A1
Автор: BRANN John E.
Принадлежит:

A method for liquid chromatography comprises steps of: mixing a sample comprising a plurality of chemical constituents with a first solvent; transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge; chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column; transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent; chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; and transferring the separated individual constituents to a detector. 1mixing a sample comprising a plurality of chemical constituents with a first solvent;transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge;chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column;transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent;chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; andtransferring the separated individual constituents to a detector.. A method for liquid chromatography comprising: This application is a Divisional application of U.S. patent application Ser. No. 13/882,116, having a 371(c) date of May 2, 2013, which is the United States National Stage application, under 35 U.S.C. 371, of International Application PCT/US2011/058229 having an international filing date of Oct. 28, 2011, which claims the benefit of the ...

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Номер записи: 44
10-02-2022 дата публикации

Method and System of Identifying and Quantifying A Protein

Номер: US20220043002A9
Автор: Shunhai WANG, Yuetian Yan
Принадлежит: Regeneron Pharmaceuticals Inc

Methods and system for identifying and/or quantifying a protein are provided herein.

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Номер записи: 45
24-01-2019 дата публикации

REFRIGERANT INTRODUCER AND GAS CHROMATOGRAPH

Номер: US20190025262A1
Автор: KOMORI Yuki, NAKANO Shigenobu, OKADA MASAYUKI
Принадлежит: SHIMADZU CORPORATION

A controller includes a temperature prediction unit. The temperature prediction unit predicts, on the assumption that a refrigerant is fed from a refrigerant feeder, an internal temperature of a column oven based on time interval information and decrement information in a memory. Thus, the temperature prediction unit can accurately predict the internal temperature of the column oven when the refrigerant is fed from the refrigerant feeder. If the refrigerant is fed from the refrigerant feeder when the predicted internal temperature of the column oven is suitable for the analysis operation, the internal temperature of the column oven can be brought closer to an appropriate temperature. As a result, the internal temperature of the column oven can be controlled with precision. 1. A refrigerant introducer for cooling a cooling target provided for a gas chromatograph , the refrigerant introducer comprising:a refrigerant feeder intermittently feeding a refrigerant to the cooling target at predetermined time intervals;a memory storage, and associating with one another, time intervals and a decrement of a temperature of the cooling target when the refrigerant has been fed to the cooling target at the time intervals; anda temperature prediction unit predicting the temperature of the cooling target based on a relationship between the time intervals and the decrement stored in the memory.2. The refrigerant introducer of claim 1 , further comprising:a cooling controller controlling the feeding of the refrigerant from the refrigerant feeder to the cooling target based on the temperature of the cooling target predicted by the temperature prediction unit.3. The refrigerant introducer of claim 2 , wherein the cooling controller periodically determines whether to feed the refrigerant or not claim 2 , and determines to postpone the feeding of the refrigerant from the refrigerant feeder to the cooling target if the temperature of the cooling target predicted by the temperature ...

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Номер записи: 46
24-01-2019 дата публикации

AUTOMATED THERMAL DESORPTION SYSTEMS AND METHODS

Номер: US20190025263A1
Автор: Tipler Andrew, Tolley Samuel
Принадлежит:

According to embodiments of the technology, an automated thermal desorption system includes a sample tube including a chamber to contain an analyte, visible indicia on the sample tube, a thermal desorption apparatus, and a sample tube monitoring system. The thermal desorption apparatus is configured to receive the sample tube and includes a heating device. The heating device is configured to heat the sample tube in the thermal desorption apparatus and thereby desorb the analyte from the sample tube. The sample tube monitoring system includes: an optical sensor configured to read the visible indicia on the sample tube and to generate an output signal corresponding thereto; and a controller configured to receive the output signal corresponding to the visible indicia from the optical sensor and to determine an orientation of the sample tube with respect to the thermal desorption apparatus based on the output signal. 1. An automated thermal desorption system including:a sample tube including a chamber to contain an analyte;visible indicia on the sample tube;a thermal desorption apparatus configured to receive the sample tube and including a heating device, wherein the heating device is configured to heat the sample tube in the thermal desorption apparatus and thereby desorb the analyte from the sample tube; and 'an optical sensor configured to read the visible indicia on the sample tube and to generate an output signal corresponding thereto; and', 'a sample tube monitoring system includinga controller configured to receive the output signal corresponding to the visible indicia from the optical sensor and to determine an orientation of the sample tube with respect to the thermal desorption apparatus based on the output signal.2. The automated thermal desorption system of wherein the visible indicia is a barcode.3. The automated thermal desorption system of wherein the barcode is substantially permanently located on the sample tube.4. The automated thermal desorption ...

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Номер записи: 47
23-01-2020 дата публикации

DISPERSIVE ELEMENT IN LIQUID CHROMATOGRAPHY SYSTEMS

Номер: US20200025723A1
Автор: Gilar Martin, GRITTI Fabrice, McDonald Thomas S.
Принадлежит:

A liquid chromatography system including a solvent delivery pump for delivering a mobile phase through the liquid chromatography system, an injector for injecting a sample into the mobile phase, a column for effecting a separation of components of the sample, and a dispersive element positioned between the injector and the column, the dispersive element configured to dilute a sample solvent in the mobile phase prior to entering the column is provided. Further dispersive elements, systems, and methods are also provided. 1. A dispersive element in a liquid chromatography system , the liquid chromatography system including a solvent pump , an injector , a column , and a detector , the dispersive element comprising:a pre-column body having an inlet end, an outlet end, and dispersing materials disposed therein, wherein the body is positioned between the injector and the column;wherein the dispersing materials dilute a mobile phase comprising a strong sample solvent prior to entering the column.2. The dispersive element of claim 1 , wherein the dispersing materials are a packed bed of chemically inert claim 1 , non-retentive sorbent materials3. The dispersive element of claim 2 , wherein the chemically inert claim 2 , non-retentive sorbent materials have a particle size between 25 μm and 100 μm.4. The dispersive element of claim 1 , wherein the pre-column body is fluidically connected to the injector at the inlet end to receive the mobile phase from the injector.5. The dispersive element of claim 4 , wherein the pre-column body is fluidically connected to the column at the outlet end opposing the inlet end claim 4 , to deliver the diluted mobile phase to the column.6. The dispersive element of claim 5 , wherein the pre-column body is directly connected to the column at the outlet end.7. The dispersive element of claim 5 , wherein the pre-column body is connected to the column via a length of tubing between the outlet end of the pre-column body and the column.8. The ...

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Номер записи: 48
23-01-2020 дата публикации

LIQUID CHROMATOGRAPHY THERMAL SYSTEM WITH THERMAL STATUS DETECTION

Номер: US20200025724A1
Автор: Chaput Cameron, Simpson David A., Soares Miguel M.
Принадлежит:

A liquid chromatography system including a solvent delivery system, a sample delivery system in fluidic communication with solvent delivery system, a liquid chromatography column located downstream from the solvent delivery system and the sample delivery system, a detector located downstream from the liquid chromatography column, a thermal chamber housing at least one of the solvent delivery system, the sample delivery system, the liquid chromatography column and the detector, an engine configured to control the temperature in the thermal chamber, a heatsink operably connected to the engine, a first temperature sensor in the thermal chamber, a second temperature sensor, and a computer system configured to receive temperature information from each of the first and second temperature sensors, and implement a method for controlling temperature in the thermal chamber. 1. A liquid chromatography system comprising:a solvent delivery system;a sample delivery system in fluidic communication with solvent delivery system;a liquid chromatography column located downstream from the solvent delivery system and the sample delivery system;a detector located downstream from the liquid chromatography column;a thermal chamber housing at least one of the solvent delivery system, the sample delivery system, the liquid chromatography column and the detector;an engine configured to control the temperature in the thermal chamber;a heatsink operably connected to the engine;a first temperature sensor within the thermal chamber;a second temperature sensor; one or more processors;', 'one or more memory devices coupled to the one or more processors; and', receiving, by the computer system, a first temperature measurement from the first temperature sensor;', 'receiving, by the computer system, a second temperature measurement from the second temperature sensor;', 'receiving, by the computer system, power information related to power utilized by the engine;', 'analyzing, by the one or more ...

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Номер записи: 49
23-01-2020 дата публикации

SUPERCRITICAL FLUID DEVICE

Номер: US20200025725A1
Автор: FUJITO Yuka, OGURA Tairo, TANAKA Kenichiro
Принадлежит: SHIMADZU CORPORATION

A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the other end of the bypass channel is connected on the analytical channel. 1. A supercritical fluid device comprising:an analytical channel;a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel;a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state;a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel;a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel;an analytical column for separating a sample introduced by the sample ...

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Номер записи: 50
23-01-2020 дата публикации

VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS

Номер: US20200025726A1
Автор: Carr Peter W., Filgueira Marcelo, Sims Carl W., Witt Klaus
Принадлежит:

A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into first and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis. 1. A multi-dimensional liquid analysis system , comprising:a first separation system including a first separation column, the first separation column configured to chromatographically separate a sample within a liquid mobile phase and to provide a first dimension outflow having a first outflow rate;a flow splitter fluidly coupled to the first dimension outflow, the flow splitter configured to split the first dimension outflow into a first split outlet flow and a second split outlet flow;a second separation system including a sample loop and a second separation column, wherein the second separation system is configured such that the sample loop receives a sample volume from the second split outlet flow, and wherein the second separation column is configured to chromatographically separate the sample volume from the second split outlet flow; anda flow controller fluidly coupled to and located downstream of one of the first split outlet flow and the second split outlet flow, the flow controller configured to control the flow rate of the one of the first split outlet flow and the second split outlet flow from the flow splitter at a controlled flow rate to obtain, in the sample volume from the second split outlet flow, a representative sampling of compounds in the first dimension outflow for ...

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Номер записи: 51
28-01-2021 дата публикации

Experimental Device for Measuring Diffusion Coefficient of Natural Gas

Номер: US20210025801A1
Автор: Jiayi Zhang, Shuyong Hu, Tingting Qiu
Принадлежит: SOUTHWEST PETROLEUM UNIVERSITY

The present invention discloses a new experimental device for measuring a diffusion coefficient of natural gas, mainly including a new core holder, a differential pressure sensor, pressure gauges, multiport valves, a confining pressure pump, a vacuum pump, a hydrocarbon gas source, a nitrogen gas source, a gas chromatograph, an intermediate container, sample chambers, a pressure stabilizing device, and pressure-sensitive alarm devices. A rubber sleeve of the new core holder can prevent a core from being stuck in the holder during core replacement due to an improper operation. The configured pressure stabilizing device is connected to the sample chambers, to ensure stable internal pressure in the chambers after sampling. In this way, one experimental variable is omitted, and an experimental result is more accurate and reliable. If gas leakage occurs. A sensor device can sense the gas leakage in time and sends an alarm to a mobile device of an experimenter.

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Номер записи: 52
04-02-2016 дата публикации

MULTI-PATH SELECTOR VALVE

Номер: US20160033049A1
Автор: NICHOLS Jon A., SMYTH James
Принадлежит:

A multi-path selector valve used in liquid chromatography and other analytical methods for directing fluid along alternate paths of a flowstream. The selector valve has a stator and a rotor. The dynamic face of the stator has a plurality of openings arranged along an inner ring, a plurality of openings arranged along an outer ring, and an annular collection groove formed in the dynamic face. The inner ring, outer ring, and annular collection groove are concentric circles. The rotor's dynamic face is configured to mate with the rear face of the stator, and has two fluid flow paths. One fluid flow path has one end at a rotational center of the rotor and another end of the fluid flow path is configured to be aligned with a stator opening along the inner ring. The second fluid flow path has one end that is configured to be aligned with the annular collection groove and another end that is configured to be aligned with a stator opening along the outer ring. 1. A dual selector valve assembly , comprising: a plurality of openings arranged along an inner ring;', 'a plurality of openings arranged along an outer ring; and', 'an annular collection groove formed in the rear face; and, 'a stator having a front face and a rear face, wherein the rear face comprisesa rotor having a front face configured to mate with the rear face of the stator, the rotor having a first fluid flow path and a second fluid flow path, the first fluid flow path comprising a first end and a second end, wherein the first end of the first fluid flow path is at a rotational center of the rotor and the second end of the first fluid flow path is configured to be aligned with a stator opening along the inner ring, and the second fluid flow path comprising a first end and a second end, wherein the first end of the second fluid flow path is configured to be aligned with the annular collection groove and the second end of the second fluid flow path is configured to be aligned with a stator opening along the outer ...

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Номер записи: 53
01-02-2018 дата публикации

APPARATUS, SYSTEM, AND METHOD FOR INTRODUCING A LIQUID INTO A VESSEL

Номер: US20180030979A1
Автор: "URen Lance", Chow Jennifer, Quarre Steve, SHAFER Edward
Принадлежит: RareCyte, Inc.

This disclosure is directed to an apparatus, system and method for introducing a liquid into a vessel. A fluid layering system includes a pump connected to a line connected to a connector, such that the connector provides an air-tight fit with the vessel. 1. A system comprising:a pump;a hose comprising a first end and a second end; a main body comprising a conduit extending in a first direction and a shaft extending in direction opposite the conduit,', 'a sealing member extending at least partially around the shaft,', 'a cavity extending through the shaft, and', 'a bore extending through the conduit and in fluid communication with the cavity; and, 'a cap comprising'} a main body comprising a first open end and a second end comprising a plug, and', 'a layering fluid,, 'a tube comprising'}wherein the first end of the hose is connected to the pump and the second end of the hose is connected to the conduit of the cap,wherein the shaft of the cap is located at least partially within the tube, andwherein the sealing member of the cap forms an air-tight seal with an inner wall of the tube.2. The system of claim 1 , further comprising:a primary vessel comprising a first open end and a second end; anda connector comprising a cavity in a first end, a second end, and cannula extending from the second end at least partially into the cavity and fluidly coupling the first and second ends,wherein the second end of the connector is at least partially located within the primary vessel, andwherein the cannula extends through the plug of the tube.3. The system of claim 2 , the primary vessel further comprising a sample.4. The system of claim 3 , the layering fluid comprising a density greater than a density of the sample or at least one fraction of the sample.5. The system of claim 3 , the layering fluid comprising a density less than a density of the sample or at least one fraction of the sample.6. The system of claim 2 , wherein the second end of the connector forms an air-tight ...

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Номер записи: 54
01-02-2018 дата публикации

ON-LINE GAS CHROMATOGRAPHY SYSTEM AND THE USE THEREOF FOR ANALYZING CATALYTIC REACTIONS

Номер: US20180031527A1
Автор: Al-Nafisah Abdullah N., Bunama Ramsey, Choi YongMan, El-Yahyaoui Khalid M.
Принадлежит:

An on-line gas chromatography system for a fixed-bed continuous flow reactor and a method for on-line gas analysis of a catalytic reaction using the gas chromatography system. A reactor flow loop, a gas chromatogram, and a hydrostatic regulator are present in the gas chromatography system, wherein the reactor flow loop contains a fixed-bed reactor, a purge gas source, a feed gas source, and a by-pass line for reaction calibration. 1. An on-line gas chromatography system for a fixed-bed continuous flow reactor , comprising: a fixed-bed continuous flow reactor having a reactor gas feed line and a reactor gas output line,', 'a purge gas source,', 'a feed gas source, and', 'a by-pass line;, 'a reactor flow loop, comprisingwherein the by-pass line, the reactor gas feed line, the reactor gas output line, the purge gas source, and the feed gas source, are in fluid communication;a gas chromatogram having a gas chromatogram gas inlet line and a gas chromatogram gas outlet line; and a vessel,', 'an exit end of the gas chromatogram gas outlet line, an exit end of the by-pass line, and', 'a liquid;, 'a hydrostatic pressure regulator, comprisingwherein the vessel contains the liquid and the vessel is in fluid communication with the exit end of the gas chromatogram gas outlet line and the exit end of the by-pass line; andwherein the exit end of the by-pass line is submerged in the liquid at a first depth and the exit end of the gas chromatogram gas outlet line is submerged in the liquid at a second depth that is less than the first depth, wherein the gas chromatogram gas outlet line has a first hydrostatic pressure and the by-pass line has a second hydrostatic pressure, and the first hydrostatic pressure is less than the second hydrostatic pressure;wherein the gas chromatogram is downstream of and in fluid communication with the reactor gas output line and the by-pass line through the gas chromatogram gas inlet line, and the gas chromatogram is upstream of and in fluid ...

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Номер записи: 55
01-02-2018 дата публикации

MEANS AND METHODS FOR MINIMIZING SWEPT AND DEAD VOLUMES IN CHROMATOGRAPHIC APPLICATIONS

Номер: US20180031528A1
Автор: KULAK Nils, MANN Matthias
Принадлежит:

The present invention relates to a device for preventing band broadening and remixing of separated fractions, and associated method, comprising a chromatographic column coupled to a flow selector, such as a rotary valve, wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL. Preferably, the column is directly plugged into the inlet port of the rotary valve and the sample is fractionated at the outlet port. 1. A device comprising or consisting of(a) a chromatographic column; and(b) a flow selector,wherein said flow selector is connected to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL.2. A kit comprising or consisting of(a) a chromatographic column; and(b) a flow selector,wherein said column and said flow selector are configured for a connection of said flow selector to the distal end of said column such that the sum of post-column swept volume and post-column dead volume is less than 10 μL.3. The kit of , furthermore comprising a manual comprising instructions for assembly of a device according to .4. The device of of the kit of or , wherein said chromatographic column(a) is empty; or(b) is filled with chromatographic material;and/orhas an inner diameter of less than 2 mm; preferably of 250 μm or less; or 200 μm or lessand/orhas a volume of 2 mL or less, preferably 100 μL or less.54. The device or kit of claim (b) , wherein said chromatographic material is selected from reversed phase , ion exchange , normal phase , hydrophilic interaction , affinity and size exclusion material.6. The device of any one of , or , or the kit of any one of to , wherein said selector is an n-way rotor valve , n preferably being 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 or 24.7. The device of any one of or to , or the kit of any one of to , ...

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Номер записи: 56
05-02-2015 дата публикации

LIMITING A RATE OF PRESSURIZATION IN A PRESSURIZED FLOW SYSTEM HAVING A CONFIGURABLE SYSTEM VOLUME

Номер: US20150034168A1
Автор: Keenan Paul, Shreve Joshua A.
Принадлежит:

Exemplary embodiments of the present disclosure are directed to limiting a rate or pressurization in a reconfigurable pressurized flow system for which different system configurations can have different system volumes. In exemplary embodiments, the system can determine a limit for the rate of pressurization by configuring the system for a closed system rate of pressurization, measuring the closed system rate of pressurization at a set flow rate, and determining a relationship between the closed system rate of pressurization and the flow rate. The system can use the relationship to dynamically set the limit for different flow rates in the system. 1. A method of limiting a rate of pressurization in a pressurized flow system having a configurable system volume , the method comprising:identifying a relationship between a flow rate of a solvent in the system and a closed system rate of pressurization of the system; andgenerating a dynamic limit to restrict the rate of pressurization based on the relationship.2. The method of claim 1 , further comprising:determining a maximum possible system volume and a minimum flow rate for the system; andmeasuring the closed system rate of pressurization for the maximum possible volume of the system with the flow rate set to the minimum flow rate.3. The method of claim 2 , wherein the relationship is a ratio and identifying the relationship comprises computing the ratio between the closed system rate of pressurization and the minimum flow rate.4. The method of claim 3 , wherein limiting the closed system rate of pressurization comprises:applying a different flow rate during an operation of the system having a first system volume; andsetting the dynamic limit based on the ratio and the different flow rate, the dynamic limit being set independent of the first system volume.5. The method of claim 4 , wherein the ratio is used to set the dynamic limit for each possible system volume.6. The method of claim 1 , wherein the relationship is a ...

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Номер записи: 57
17-02-2022 дата публикации

PREPARATIVE CHROMATOGRAPH

Номер: US20220050086A1
Автор: IRIKI Takayuki
Принадлежит:

An injection valve switches between a first state in which a sample loop is connected to a separation flow path through which a mobile phase from a liquid sender flows and a second state in which the sample loop is disconnected from the separation flow path. A pump speed determiner, in a case where a sample intake operation by a syringe pump is started immediately after the injection valve is switched from the second state to the first state, and a filling operation of filling the sample loop with the sample by the syringe pump is started after the intake operation is completed, determines an intake operation speed of the syringe pump that is required in order for the filling operation to complete immediately before the injection valve is switched from the second state to the first state next time using a set injection interval time. The syringe pump operates at the intake operation speed determined by the pump speed determiner while performing the intake operation. The sample is injected by the injector at intervals of the set injection interval time. 1. A preparative chromatograph comprising:a liquid sender that sends a mobile phase;an injector that has a syringe pump for taking and discharging a sample, a sample loop for holding the sample temporarily and an injection valve that switches between a first state in which the sample loop is connected to a separation flow path through which a mobile phase from the liquid sender flows and a second state in which the sample loop is disconnected from the separation flow path, and injects the sample into the separation flow path by connecting the sample loop filled with the sample to the separation flow path;a separation column that is provided on the separation flow path and is to separate the sample that is injected into the separation flow path by the injector into components;a detector that is provided on the separation flow path and is to detect components generated by separation in the separation column;a fraction ...

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Номер записи: 58
17-02-2022 дата публикации

NON-CONTIGUOUS SAMPLE FRACTIONATING AND CONCATENATING DEVICE AND DUAL ONLINE MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY SYSTEM HAVING THE SAME

Номер: US20220050087A1
Автор: LEE Hangyeore, Lee Sang-Won
Принадлежит: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Disclosed are non-contiguous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-contiguous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions. 1. A non-contiguous sample fractionating and concatenating device , comprising:a sample supply module which supplies a sample to be analyzed; anda sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.2. The non-contiguous sample fractionating and concatenating device according to claim 1 , wherein the sample fractionation module includes:a first fractionation valve connected to the sample supply module, into which the sample is introduced;a second fractionation valve provided adjacent to the first fractionation valve; anda ...

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Номер записи: 59
17-02-2022 дата публикации

LIQUID CHROMATOGRAPH MASS SPECTROMETER

Номер: US20220050091A1
Автор: Hasegawa Hideki, Hashimoto Yuichiro, Sugiyama Masuyuki
Принадлежит:

A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths and analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve, connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal. 2. The liquid chromatograph mass spectrometer according to claim 1 , wherein claim 1 , after driving the first valve claim 1 , the controller determines whether an ion source of the mass spectrometry unit is clogged based on the pressure of the second flow path measured by the pressure gauge.3. The liquid chromatograph mass spectrometer according to claim 2 , wherein claim 2 , when it is determined that clogging does not occur in the ion source of the mass spectrometry unit claim 2 , the controller determines that clogging occurs on a side of the separation column.4. The liquid chromatograph mass spectrometer according towherein the first liquid feed pump and the second liquid feed pump feed liquid at different pressures.5. The liquid chromatograph mass spectrometer according to claim 1 , further comprising:a plurality of the first flow paths;a plurality of the separation columns, each of which is provided in the plurality of the first flow paths; anda second valve that switches a flow path to any of the plurality of the first flow paths.6. The liquid chromatograph mass spectrometer according to claim 5 , ...

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Номер записи: 60
31-01-2019 дата публикации

GAS CHROMATOGRAPH DEVICE WITH INDUCTIVELY HEATED COLUMN AND METHOD OF USE THEREOF

Номер: US20190033268A1
Автор: CHAPMAN Richard Michael, Collins, DAVIS Michael Craig, JR. Michael John, SABOLIS Alyssa Whitney, SCHEID Daniel Charles, UNITES Brian Thomas
Принадлежит:

A gas chromatograph device includes an inductively heated column configured for gas chromatography. The gas chromatograph includes a column configured for gas chromatography and an inductive heating source. The inductive heating source is configured to directly or indirectly heat the column. The inductive heating source includes an inductive heating element or coil. The inductive heating element or coil is configured to induce a current directly or indirectly in the column. Wherein, the column in the gas chromatograph is inductively heated via the inductive heating source. 1. A gas chromatograph device comprising:a column configured for gas chromatography; andan inductive heating source configured to directly or indirectly heat the column, said inductive heating source includes an inductive heating element or coil, said inductive heating element or coil is configured to induce a current directly or indirectly in the column;wherein, the column in the gas chromatograph is inductively heated via the inductive heating source.2. The gas chromatograph device according to claim 1 , wherein the gas chromatograph does not require an oven.3. The gas chromatograph device according to claim 1 , wherein the inductive heating element or coil is configured to induce a current directly into a skin of an outer layer of the column claim 1 , wherein the column is a metal or silica column configured for gas chromatography.4. The gas chromatograph device according to claim 3 , wherein the inductive heating element or coil is configured to directly heat the column controllably up to a needed temperature and hold the column there to the needed temperature.5. The gas chromatograph device according to further comprising at least one fan claim 4 , wherein the inductive heating element or coil is configured to allow the gas chromatograph to cool the column by turning off the inductive heating element or coil and blowing or fanning cool air over the column via the at least one fan.6. The gas ...

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Номер записи: 61
31-01-2019 дата публикации

Gas chromatograph device with positioning system for the inlet liner and the column and method of use thereof

Номер: US20190033270A1
Автор: Alyssa Whitney SABOLIS, Brian Thomas UNITES, Daniel Charles SCHEID, Michael Craig DAVIS, Michael John Collins, Jr., Richard Michael CHAPMAN
Принадлежит: CEM Corp

A gas chromatograph with a positioning system for the inlet liner and the column includes a column and the positioning system for the inlet liner and the column. The column is configured for gas chromatography. Wherein, the positioning system for the inlet liner and the column is configured to position the inlet liner and the column with respect to one another. The positioning system for the inlet liner and the column is configured to repeatably and optimally position the inlet liner and the column with respect to one another. The positioning system for the inlet liner and the column positions the inlet liner in a perpendicular orientation to the column.

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Номер записи: 62
31-01-2019 дата публикации

GAS CHROMATOGRAPH DEVICE WITH COLUMN RECOGNITION TECHNOLOGY SYSTEM AND METHOD OF USE THEREOF

Номер: US20190033271A1
Автор: CHAPMAN Richard Michael, Collins, DAVIS Michael Craig, JR. Michael John, SABOLIS Alyssa Whitney, SCHEID Daniel Charles, UNITES Brian Thomas
Принадлежит:

A gas chromatograph with column recognition technology system for the column includes a column and the column recognition technology system for the column. The column is configured for gas chromatography. The column includes column parameters associated with the column. The column recognition technology system may be configured to auto-recognize the column in the gas chromatograph device. Wherein, the column recognition technology system may be configured to auto-recognize the column parameters associated with the auto-recognized column. 1. A gas chromatograph device comprising:a column configured for gas chromatography including column parameters associated with the column; anda column recognition technology system configured to auto-recognize the column in the gas chromatograph device;wherein, the column recognition technology system is configured to auto-recognize the column parameters associated with the auto-recognized column.2. The gas chromatograph device according to claim 1 , wherein:the column recognition technology system is configured for allowing programming of the gas chromatograph device by automatically inputting the column parameters associated with the auto-recognized column into software of the gas chromatograph device so that the user has much less to program when running the gas chromatograph device;the column recognition technology system is configured to improve performance of the gas chromatograph device by suggesting other operating parameters based on the auto-recognized column;the column recognition technology system is configured to increase lifetime of the auto-recognized column;the column recognition technology system is configured to decrease issues with the gas chromatograph device by warning the user against operating parameters that are not compatible with certain column types;the column recognition technology system is configured to warn the user against using high column temperatures for temperature sensitive columns;the column ...

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Номер записи: 63
30-01-2020 дата публикации

LIQUID DELIVERY DEVICE AND FLUID CHROMATOGRAPH

Номер: US20200032780A1
Автор: YANAGIBAYASHI Jun
Принадлежит: SHIMADZU CORPORATION

A liquid delivery device includes a pump head having a pump chamber provided in the inside, a plunger whose tip is slidably inserted into the pump chamber, and at least one plunger pump having a drive mechanism that reciprocates the plunger in its axial direction. Then, at least one of the plunger pumps is a pressurizing pump that pressurizes a mobile phase including a compressible fluid sucked into the pump chamber and then discharges the mobile phase from the pump chamber, and at least the pump head of the pressurizing pump includes a cooling part that is connected to an outlet channel from the pump chamber, and allows the pump head to absorb heat of the mobile phase discharged from the pump chamber to cool the mobile phase. 110-. (canceled)11. A liquid delivery device comprising:at least one or more plunger pumps, wherein the plunger pumps each include a pump head having a pump chamber provided in an inside, a plunger whose tip is slidably inserted into the pump chamber, and a drive mechanism that reciprocates the plunger in an axial direction thereof, 'at least the pump head of the pressurizing pump includes a cooling part formed by channels connected with an outlet channel of the pump chamber, the cooling part, is configured to cause the pump head to absorb heat of a mobile phase that is discharged from the pump chamber and flows into the channels, and is provided to cool the mobile phase.', 'at least one of the plunger pumps is a pressurizing pump that pressurizes a mobile phase including a compressible fluid sucked into the pump chamber and then discharges the mobile phase from the pump chamber, and'}12. The liquid delivery device according to claim 11 , wherein the channels forming the cooling part are a flat plate-shaped channel in which a ratio of an internal surface area to internal capacity is larger than that of the outlet channel.13. The liquid delivery device according to claim 11 , wherein the channels forming the cooling part are a plurality of ...

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Номер записи: 64
30-01-2020 дата публикации

LIQUID CHROMATOGRAPHY ANALYTE REACTION AND ANALYSIS SYSTEM

Номер: US20200033306A1
Автор: Hofflander Mike, Jones Andrew, Saunders Tommy
Принадлежит: Activated Research Company, LLC

In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, an acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable. 1. A system for the detection and quantification of organic molecules from a liquid chromatograph comprising:a liquid chromatograph having an outlet;a device comprising a heated rotating disk, an inlet for effluent from the liquid chromatograph with the inlet depositing the effluent onto the disk, a solvent vent for capturing volatilized gases, an inlet for gases such as air, helium or hydrogen, a source of concentrated energy, and a vent for receiving transformed analyte from the action of the concentrated energy;a conduit connecting the outlet of the chromatograph with the inlet on the device for receiving effluent from the chromatograph;a detector for detecting and quantifying organic molecules, the detector having an inlet; anda conduit connecting the vent in the device for receiving transformed analyte to the inlet of the detector.2. The system of claim 1 , wherein the rotating disk comprises a circular groove with the inlet depositing the effluent into the groove.3. The system of claim 1 , wherein the device is heated by a resistive heater.4. The system of claim 1 , wherein the device is sealed.5. The system of claim 4 , wherein the device is pressurized.6. The system of claim 4 , wherein the device is sealed with rubber and/or polymer seals.7. The system of claim 6 , wherein the seals are spring ...

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Номер записи: 65
04-02-2021 дата публикации

SYSTEM AND METHOD FOR PROVIDING ON-LINE MEASUREMENT OF IMPURITIES IN LIQUID ETHYLENE OXIDE STREAMS

Номер: US20210033571A1
Автор: Callender Robert M., Emery Clair J., Idowu Ademola D., Mahoney Louise A.
Принадлежит:

Automated systems and methods for obtaining of the concentration of impurities in a liquid ethylene oxide product stream are shown and described. The systems and methods employ remote injection and flash vaporization of small volumes of liquid ethylene oxide into a carrier gas to minimize polymerization of the ethylene oxide and accumulation of polymerized ethylene oxide. Ethylene oxide peaks are diverted from the gas chromatograph effluent detector to stabilize baseline signal errors and avoid errors in the calculation of an impurity with an adjacent retention time peak. The systems and methods may be used for feedback, feedforward, dynamic matrix, and/or model-based predictive control of ethylene oxide purity. The systems and methods reduce lag times and errors associated with relying on laboratory analyses to make process adjustments. 1. An automated method for determining the concentration of impurities in a liquid ethylene oxide stream having at least one impurity as the liquid ethylene oxide stream is produced by a processing unit , comprising:injecting a sample volume from the liquid ethylene oxide stream into a gas chromatograph train having a gas chromatograph effluent stream; andgenerating at least one signal indicative of the corresponding concentration of the at least one impurity.2. The automated method of claim 1 , wherein the step of injecting a sample volume from the liquid ethylene oxide stream into a gas chromatograph train having a gas chromatograph effluent stream comprises accumulating the sample volume of liquid ethylene oxide from the liquid ethylene oxide stream in a sample chamber that is in selective fluid communication with the liquid ethylene oxide stream and the gas chromatograph train claim 1 , and fluidly coupling the sample chamber to the gas chromatograph train.3. The automated method of claim 1 , wherein the at least one impurity is selected from the group consisting of acetaldehyde claim 1 , formaldehyde claim 1 , carbon dioxide ...

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Номер записи: 66
04-02-2021 дата публикации

SAMPLE DISPATCHING WITH FLUIDIC SAMPLE RETAINING

Номер: US20210033572A1
Автор: Glauner Thomas, Ortmann Thomas
Принадлежит:

A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the sampling path, a sampling fluid drive, a mobile phase drive, and a separating device. In a feed injection configuration of the switching unit, the mobile phase drive, the separating device, and the sampling path are coupled together in a coupling point for combining a flow from the sampling fluid drive containing the fluidic sample retained by the retaining unit with a flow of the mobile phase from the mobile phase drive. 1. A sample dispatcher for a fluid separation apparatus , wherein the fluid separation apparatus comprises a mobile phase drive , configured for driving a mobile phase , and a separating device configured for separating a portion of a fluidic sample when comprised within the mobile phase , the sample dispatcher comprising: the sampling unit is configured for receiving the fluidic sample,', 'the sampling volume is configured for temporarily storing an amount of the received fluidic sample, and', 'the retaining unit is configured for receiving and retaining from the sampling volume at least a portion of the fluidic sample stored in the sampling volume, wherein the retaining unit comprises different retention characteristics for different components of the fluidic sample; and, 'a sampling path comprising a sampling volume, a sampling unit, and a retaining unit, whereina switching unit coupling to the sampling path, a sampling fluid drive, the mobile phase drive, and the separating device,wherein the sampling fluid drive is configured for moving at least a portion of ...

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Номер записи: 67
04-02-2021 дата публикации

BINARY PUMP AND LIQUID CHROMATOGRAPH PROVIDED WITH SAME

Номер: US20210033573A1
Автор: FUJISAKI Shinichi
Принадлежит:

A binary pump includes a switching valve that can be switched to a state (first state or second state) in which only one of a first pump part and a second pump part is connected to an output part, and a state (third state) in which both the first pump part and the second pump part are connected to the output part, and has a function of preventing a backflow of liquid by switching a state of the switching valve, in particular, a function of preventing a backflow of liquid when liquid delivery is performed by using both the first pump and the second pump. 1. A binary pump comprising:a first pump part;a second pump part provided separately from the first pump part;an output part for outputting liquid delivered by the first pump part and/or the second pump part;a switching valve that includes a first liquid delivery port to which the first pump part is connected, a second liquid delivery port to which the second pump part is connected, and an output port communicating with the output part, and is configured to be switched to any one of a first state, a second state, and a third state, wherein the first state is a state in which the first liquid delivery port is connected to the output port and the second liquid delivery port is not connected to any port, the second state is a state in which the second liquid delivery port is connected to the output port and the first liquid delivery port is not connected to any port, and the third state is a state in which both the first liquid delivery port and the second liquid delivery port are connected to the output port;a first pressure sensor that detects a pressure in a space which exists between the first pump part and the switching valve as a first pressure;a second pressure sensor that detects a pressure in a space which exists between the second pump part and the switching valve as a second pressure;a backflow calculation part that is configured to obtain a change rate of a system pressure detected by the first pressure ...

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Номер записи: 68
04-02-2021 дата публикации

Apparatus for Processing a Liquid Comprising a Target Substance

Номер: US20210033574A1
Автор: Andrew Topping, Charles HEISE, James Pullen, Jonathan HAIGH, Tibor Nagy
Принадлежит: FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED

Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided. The apparatus comprises at least a first and a second means for carrying out a unit operation, each means for carrying out a unit operation comprising a feed for a liquid in fluid connection with the inlet of a flow-controller comprising a variable flow inlet valve and an outlet, wherein at least one of the means for carrying out a unit operation comprises feeds for at least two liquids, the feeds being in fluid connection with the inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two liquids, the flow-controller also comprising an outlet; a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with the mixed bioprocessing liquids to produce a device feed; a device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed; and a means for imparting flow through the flow controller and from the feed for the liquid feedstock through the processing device via the device inlet; and wherein the feed for a liquid feedstock comprising the target substance for the second means for carrying out a unit operation comprises the outlet from the first means for carrying out a unit operation.

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Номер записи: 69
11-02-2016 дата публикации

APPARATUS AND METHODS FOR CONTROLLING THE TEMPERATURE OF A CHROMATOGRAPHY COLUMN

Номер: US20160038853A1
Автор: Shreve Joshua A.
Принадлежит: WATERS TECHNOLOGIES CORPORATION

An apparatus for controlling the temperature of a chromatography column includes a thermal-isolation vessel; a heater in thermal communication with the chromatography column and disposed on the thermal-isolation vessel; a temperature sensor disposed to directly measure the temperature of the chromatography column; and a control unit in signal communication with the temperature sensor to control the heater in response to LIGHT the direct measurement. 1. An apparatus for controlling the temperature of a chromatography column , comprising:a thermal-isolation vessel;a heater in thermal communication with the chromatography column, the heater disposed on the thermal-isolation vessel;a temperature sensor disposed to directly measure the temperature of the chromatography column; anda control unit in signal communication with the temperature sensor, the control unit configured to control the heater, in response to direct measurement of the temperature of the column by the temperature sensor.2. The apparatus of claim 1 , wherein the temperature sensor is disposed in contact with the chromatography column.3. The apparatus of claim 1 , wherein the temperature sensor is a non-contact temperature sensor.4. The apparatus of claim 3 , wherein the non-contact temperature sensor is an infrared temperature sensor.5. The apparatus of further comprising a target of known emissivity attached to the chromatography column.6. The apparatus of further comprising an infrared-transmissive material disposed to protect the infrared temperature sensor.7. The apparatus of further comprising additional temperature sensors disposed to directly measure the temperature of the chromatography column.8. The apparatus of claim 1 , wherein the temperature sensor directly measures the temperature at the midpoint of the chromatography column.9. The apparatus of wherein the heater comprises a pre-heater on thermal-isolation vessel.10. The apparatus of further comprising at least one temperature sensor ...

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Номер записи: 70
08-02-2018 дата публикации

CPC DISTRIBUTION CHROMATOGRAPHY OF CANNABINOIDS

Номер: US20180036278A1
Автор: Rutz Andreas
Принадлежит: Bionorica Ethics GmbH

The invention relates to cannabinoids and their isolation and purification and to obtaining them by means of centrifugal partition chromatography. 111.-. (canceled)12. A method for separating and/or purifying cannabinoids from a cannabis extract , including at least one liquid-liquid centrifugal partition chromatography step , wherein a solvent from the group of cyclohexane , heptane , or octane is selected and is kept stationary by centrifugal force , including and a second non-miscible liquid phase.13. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , wherein the first phase is n-heptane.14. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , wherein the second phase is acetonitrile claim 12 , methanol claim 12 , ethylacetate or water.15. The method for separating and/or purifying cannabinoids from a cannabis extract according to claim 12 , selected from the group consisting of:n-heptane/acetonitrile, n-heptane/ethylacetate/acetonitrile, n-heptane/ethylacetate/t-butyl methyl ether/acetonitrile,n-heptane/ethylacetate/methanol/water,n-heptane/methanol/water, n-heptane/ethanol/water,n-heptane/acetone/water, n-heptane/methanol/acetonitrile,n-heptane/ethanol/acetonitrile,n-heptane/acetone/acetonitrile,n-heptane/chloroform/acetonitrile,n-heptane/chloroform/methanol, n-heptane/methanol,n-heptane/ethanol/methanol,n-heptane/n-butanol/acetonitrile, n-heptane/2-propanol/water, n-heptane/n-propanol/water, n-heptane/2-propanol/acetonitrile, n-heptane/n-propanol/acetonitrile, n-heptane/dichloromethane/acetonitrile,n-heptane/dichloromethane/methanol,n-heptane/tetrahydrofuran/acetonitrile,n-heptane/benzotrifluoride/acetonitrile, Cyclohexane/methanol/water,Cyclohexane/methanol/acetonitrile,Cyclohexane/t-butyl methyl ether/water, Cyclohexane/acetonitrile/water, andIsooctane/methanol, isooctane/methanol/water, Isooctane/ethyl acetate/methanol/water.16. The method for separating ...

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Номер записи: 71
09-02-2017 дата публикации

PASSIVE COLUMN PRE-HEATER FOR USE IN CHROMATOGRAPHIC SYSTEMS

Номер: US20170038345A1
Автор: Joudrey Kurt D., Shreve Joshua A.
Принадлежит:

A passive pre-heater assembly includes a thermally conductive heat-spreading block and a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block. The plurality of the pre-heaters exchanges heat with the thermally conductive heat-spreading block. Each pre-heater includes a thermally conductive base in thermal communication with the heat-spreading block, and a plurality of thermally conductive fins is in thermal communication with the thermally conductive base. The plurality of fins of each pre-heater exchanges heat convectively with ambient air and conductively with the thermally conductive base of that pre-heater. A given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater. The thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater. 1. A passive pre-heater assembly comprising:a thermally conductive heat-spreading block; and a thermally conductive base in thermal communication with the heat-spreading block; and', 'a plurality of thermally conductive fins in thermal communication with the thermally conductive base of the pre-heater, the plurality of fins being adapted to exchange heat convectively with ambient air and conductively with the thermally conductive base of the pre-heater, and, 'a plurality of passive pre-heaters in thermally conductive communication with the heat-spreading block to exchange heat with the thermally conductive heat-spreading block, each pre-heater comprisingwherein a given one of the passive pre-heaters further comprises a tube in thermally conductive contact with the thermally conductive base of the given passive pre-heater, and wherein the thermally conductive heat-spreading block exchanges heat with a fluid passing through the tube of the given passive pre-heater.2. The passive pre-heater assembly of claim 1 , wherein the ...

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Номер записи: 72
09-02-2017 дата публикации

CONVECTIVELY CONTROLLED ADIABATIC COLUMN CHAMBER FOR USE IN CHROMATOGRAPHIC SYSTEMS

Номер: US20170038346A1
Автор: Joudrey Kurt D., Shreve Joshua A.
Принадлежит:

A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path. An air mover disposed in the airflow path generates a flow of air within the duct system. A heat exchanger system disposed in the airflow path near the air to exchange heat with the air as the air flows past the heat exchanger system. The air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber. 1. An enclosure , comprising:a column chamber adapted to hold one or more chromatography separation columns;a duct system providing an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path;an air mover disposed in the airflow path, the air mover generating a flow of air within the duct system; anda heat exchanger system disposed in the airflow path near the air mover, the heat exchanger system exchanging heat with the air as the air flows past the heat exchanger system, wherein the air circulates through the duct system around the column chamber, convectively exchanging heat with the column chamber to produce a thermally conditioned environment for the one or more chromatography separation columns held within the column chamber.2. The enclosure of claim 1 , wherein the heat exchanger system includes a heater that heats the air to a preset temperature as the air flows past the heat exchanger system claim 1 , such that the circulated air convectively heats the column chamber and produces a heated environment for the one or more chromatography separation columns held ...

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Номер записи: 73
09-02-2017 дата публикации

CHROMATOGRAPHY SYSTEMS WITH MOBILE PHASE GENERATORS

Номер: US20170038347A1
Автор: Tipler Andrew
Принадлежит:

Certain configurations of a gas chromatography system comprising an internal gas generator are described. In some instances, the gas chromatography system may comprise an internal hydrogen generator to provide hydrogen gas to a chromatography column for separation of analyte species. In certain examples, the gas chromatography system can be operated without any external gas inputs. 120-. (canceled)21. A gas chromatography system comprising a housing comprising an internal gas generator configured to generate hydrogen and use the generated hydrogen as a carrier gas for the introduction and separation of analyte species into the gas chromatography system.22. The gas chromatography system of claim 21 , in which the system is further configured to use the generated hydrogen gas as a fuel for a detector of the gas chromatography system or is further configured to use the generated hydrogen gas as a makeup gas for a detector of the gas chromatography system.23. The gas chromatography system of claim 22 , in which the system is configured to generate oxygen gas concurrently with generation of the hydrogen.24. The gas chromatography system of claim 23 , in which the internal gas generator comprises an electrolysis device.25. The gas chromatography system of claim 24 , in which the electrolysis device is fluidically coupled to a water reservoir.26. The gas chromatography system of claim 25 , in which the electrolysis device is configured to generate hydrogen and oxygen gas from electrolysis of water received from the water reservoir.27. The gas chromatography system of claim 26 , in which the electrolysis device comprises an anode claim 26 , a cathode and a membrane between the anode and the cathode.28. The gas chromatography system of claim 27 , further comprising a gas reservoir fluidically coupled to the internal gas generator and configured to store at least one gas produced by the gas generator.29. The gas chromatography system of claim 27 , further comprising a ...

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Номер записи: 74
12-02-2015 дата публикации

Valve switch modulation for reducing errors due to oscillations of the inlet fluid of a pump system

Номер: US20150043303A1
Автор: Joshua A. Shreve, Steven J. Ciavarini
Принадлежит: Waters Technologies Corp

Described is a method of reducing liquid composition errors in a low-pressure mixing pump system. Packets representing the switching intervals of each component of the desired fluid mixture are provided to an intake of the mixing pump system. For each packet, a switching time associated with at least one of the components in the packet is modulated. Modulated switching times are based on time offsets that are specifically selected according to the undesirable frequency characteristic of an intake response of the mixing pump system. The average of the volumes contributed by the packets thus modulated is equal to a component volume that achieves a desired proportion of the component in the output flow of the mixing pump system. Modulated switching times enable the reduction or elimination of composition error in the output flow of the mixing pump system.

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Номер записи: 75
07-02-2019 дата публикации

GAS CHROMATOGRAPH

Номер: US20190041368A1
Автор: Kashihara Minoru, NAKAMA Yuji, SHIBAMOTO Shigeaki
Принадлежит: SHIMADZU CORPORATION

Provided is a gas chromatograph including a column which separates a sample; a detector which is configured to alternately introduce a carrier gas containing a sample component separated by the column and a carrier gas alone into a detection unit by changing an inflow point of the carrier gas to acquire a signal; an analysis information input unit with which analysis information is input; a data retaining unit which retains data indicating a relationship between a column flow rate and a carrier gas flow rate which is obtained in advance; and calculation unit which is configured to calculate the carrier gas flow rate on the basis of the analysis information input from the analysis information input unit and calculate the carrier gas flow rate according to the calculated column flow rate by using the calculated column flow rate and the data retained in the data retaining unit. 1. A gas chromatograph comprising:a column which separates a sample;a detector which is configured to alternately introduce a carrier gas containing a sample component separated by the column and a carrier gas alone into a detection unit by changing an inflow point of the carrier gas to acquire a signal;an analysis information input unit with which analysis information is input;a data retaining unit which retains data indicating a relationship between a column flow rate and a carrier gas flow rate which is obtained in advance; anda calculation unit which is configured to calculate the column flow rate on the basis of the analysis information input from the analysis information input unit and calculate the carrier gas flow rate according to the calculated column flow rate by using the calculated column flow rate and the data retained in the data retaining unit.2. The gas chromatograph according to claim 1 , wherein the analysis information is at least one of an inner diameter of the column claim 1 , a length of the column claim 1 , a temperature claim 1 , and a pressure applied to the column.3. ...

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Номер записи: 76
06-02-2020 дата публикации

Chromatography System

Номер: US20200041466A1
Автор: Merrick Mark Firmer
Принадлежит:

A chromatography system includes a modulator, a chromatograph, a cooler, and a detector. The chromatograph is connected to the modulator by a first heated transfer line. The detector is connected to the modulator by a second heated transfer line. The cooler is connected to the modulator. The modulator is arranged outside of the chromatograph. 1. A chromatography system comprising:a modulator;a chromatograph connected to the modulator by a first heated transfer line;a detector connected to the modulator by a second heated transfer line; anda cooler connected to the modulator, wherein the modulator is arranged outside of the chromatograph.2. The chromatography system according to claim 1 , further comprising:a secondary oven connected to the modulator, wherein the modulator is connected to the first heated transfer line, and the secondary oven is connected to the second heated transfer line.3. The chromatography system according to claim 2 , further comprising a heat pipe or a thermosiphon system connecting the modulator with the cooler claim 2 , the heat pipe or the thermosiphon system is configured to remove heat from the modulator.4. The chromatography system according to claim 2 , wherein the cooler is disposed on the modulator.5. The chromatography system according to claim 2 , wherein the secondary oven includes a cylindrical shape.6. The chromatography system according to claim 5 , wherein the secondary oven includes a cylindrical ceramic heater.7. The chromatography system according to claim 2 , wherein the modulator comprises:a heater defining a void; anda capillary column arranged in the void of the heater.8. The chromatography system according to claim 7 , wherein the modulator is connected to a heat pipe or a thermosiphon system claim 7 , and wherein the heater is in direct contact with the heat pipe or the thermosiphon system.9. The chromatography system according to claim 7 , wherein the heater is disposed on a surface of the capillary column.10. The ...

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Номер записи: 77
06-02-2020 дата публикации

Chromatographic analysis with low pressure dual gradient refocusing

Номер: US20200041467A1
Автор: Nicolai BACHE, Ole Vorm
Принадлежит: Evosep Aps

There is provided a system for separation of analytes in a solution. The system encompasses a cartridge or trapping column enclosing a sorbent for binding the analytes in the solution and a conduit establishing a fluid link to a valve having a holding-loop to achieve elution through the cartridge at low pressures. Prior to entry into the loop, the eluent is diluted or modified by a confluent flow stream. The valve is switchable to a position following the elution from the cartridge for emptying the holding loop through an outlet port at high pressures comparable to those required for chromatographic columns. The system may use parallel gradient formation/elution to stagger analyses so that essentially the only analytical phase that hinders a 100% duty cycle is the time required for moving the first analyte from the valve and to the detector.

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Номер записи: 78
06-02-2020 дата публикации

MODULAR AUTOMATED CHROMATOGRAPHY SYSTEM

Номер: US20200041468A1
Автор: AVARBOCK Bob, BAKER Ken, Bland Wayne, GORDON Alec, Iovanni Robert, MAVANDADI Farah, Price Glenn, SCHULTZ Christof
Принадлежит:

Valves, pumps, detectors, sample loops, fraction collectors and the like are individually incorporated into modules that are mountable at individual mounting sites on a base unit which also supports one or more chromatography columns. Each module includes fluid connections to other modules and a microcontroller joining the module to a computed and monitor through an electronic connector at each mounting site. The fluid connections between the modules and the column(s) are removed from the electronic connections and accessible to the user. A software platform may recognize the modules and their locations, coordinate fluid connections between the modules, and provide a variety of control, monitoring, data generating and data processing functions to generate chromatographic data. The software platform may also provide graphical tools for designing chromatographic methods from a library of phases. 1. A method of operating a chromatography system , the method comprising:receiving a plurality of modules into a mounting frame, wherein each of the plurality of modules comprises a fluid manipulation component and a microcontroller that transmits operational signals to the fluid manipulation component in response to commands received from outside the module, and wherein the mounting frame further includes a plurality of bays, each of the plurality of bays constructed to receive a single module, and each of the plurality of bays comprising a signal connector that couples to and communicates with the microcontroller of a module mounted in the bay, wherein at least some of the bays are constructed to receive single modules interchangeably with other modules, and wherein the fluid manipulation components are connected together by fluid lines in an arrangement for implementing a flow scheme;displaying a depiction of the flow scheme in the user interface, wherein the depiction of the flow scheme is arranged generally linearly with flow from left to right, regardless of the physical ...

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Номер записи: 79
07-02-2019 дата публикации

METHOD FOR PREDICTING THE CONDUCTIVITY OF A LIQUID MIXTURE

Номер: US20190042704A1
Автор: Carredano Enrique
Принадлежит: GE HEALTHCARE BIO-SCIENCES AB

In a method of preparing a liquid solution by mixing ingredients according to a predetermined recipe, wherein at least one pair of species of the liquid solution is derived from a weak electrolyte and corresponds to an acid-base pair, the conductivity of the liquid solution is predicted by: 2. The method of claim 1 , wherein the Kohlrausch coefficient is expressed as K=A+B×Λ claim 1 , wherein A and B are temperature-dependent constants and Λis as previously defined claim 1 , and wherein the predetermined values for K in the data set are calculated from values for A and B obtained by said fitting of step (ii).3. The method of claim 1 , wherein the Kohlrausch coefficient is expressed as K=A+B+w×Λ claim 1 , wherein A and B are temperature-dependent constants claim 1 , w is the Onsager factor claim 1 , and Λis as previously defined claim 1 , and wherein the predetermined values for K in the data set are calculated from values for A claim 1 , B and w obtained by said fitting of step (ii).4. The method of claim 1 , wherein the formate buffer solution further comprises sodium chloride.5. The method of claim 1 , further comprising controlling a buffer formulation system based on the predicted conductivity.6. The method of claim 1 , further comprising controlling an in-line dilution system based on the predicted conductivity.7. The method of claim 1 , further comprising using the predicted conductivity as a design of experiment (DoE) parameter in screening experiments.9. The method of claim 1 , wherein the Kohlrausch coefficient is expressed as K=A+B×Λ claim 1 , wherein A and B are temperature-dependent constants and Λis as previously defined claim 1 , and wherein the predetermined values for K in the data set are calculated from values for A and B obtained by said fitting of step (ii).10. The method of claim 1 , wherein the Kohlrausch coefficient is expressed as K=A+B+w×Λ claim 1 , wherein A and B are temperature-dependent constants claim 1 , w is the Onsager factor claim 1 ...

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Номер записи: 80
18-02-2021 дата публикации

MIXER FOR CHROMATOGRAPHY SYSTEM

Номер: US20210048415A1
Автор: Andrews Richard Wayne, Beals Peyton C., Cormier Sylvain Gilles
Принадлежит:

Described is a mixer for a chromatography system. The mixer includes an inlet manifold channel, an outlet manifold channel and a plurality of transfer channels. The inlet manifold channel has an inlet at a proximal end of the inlet manifold channel for receiving an inlet flow. The transfer channels are fluidly connected between the inlet and outlet manifold channels. The respective fluid connections are distributed along each of the inlet and outlet manifolds channels. The transfer channels have different volumes. The mixer may be formed of a plurality of layer and the layers may be diffusion bonded to each other. 1. A mixer comprising:an inlet manifold channel having an inlet at a proximal end of the inlet manifold channel for receiving an inlet flow;an outlet manifold channel; anda plurality of transfer channels fluidly connected between the inlet and outlet manifold channels, wherein the respective fluid connections are distributed along each of the inlet and outlet manifolds channels and wherein the transfer channels have different volumes.2. The mixer of claim 1 , wherein the respective fluid connections of the plurality of transfer channels are distributed substantially equally along the length of the inlet and outlet manifolds.3. The mixer of claim 1 , wherein the plurality of transfer channels extends substantially within the same plane from the inlet and outlet manifold channels at each fluid connection.4. The mixer of claim 1 , wherein the transfer channels are arranged in substantially the same plane.5. The mixer of wherein the plurality of transfer channels comprises a flow restrictor.6. The mixer of claim 1 , wherein the outlet manifold channel has an outlet at a distal end of the outlet manifold channel for delivering an outlet flow and wherein the proximal end of the outlet manifold channel is arranged adjacent the distal end of the inlet manifold channel.7. The mixer of claim 1 , wherein the fluid connection of a first one of the transfer channels to ...

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Номер записи: 81
16-02-2017 дата публикации

Feedback control device

Номер: US20170045482A1
Автор: Hiroomi Goto, Takahiro Mori, Tsunehiro Inoue
Принадлежит: Shimadzu Corp

A feedback control apparatus includes: a detector configured to detect an output value based on a controlled object; a P control circuit including a differential amplifier circuit and an analog circuit, the differential amplifier circuit being configured to receive a detection value of the detector and a target value, the analog circuit being configured to output a P control component V P to an output of the differential amplifier circuit; an I control unit configured to output an I control component V I by integrating a deviation of the detection value from the target value by digital processing; and a driver element configured to be driven based on the P control component V P from the P control circuit and the I control component V I from the I control unit to control the controlled object.

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Номер записи: 82
15-02-2018 дата публикации

THERMAL ISOLATION IN A FLUIDIC BLOCK OF AN ACTIVELY CONTROLLING THERMISTOR

Номер: US20180045691A1
Автор: Keenan Paul, KHEYFETS Greg, Shreve Joshua A.
Принадлежит:

A fluidic block has a thermally conductive body with a first end and a second end opposite the first end. The body has a cutout portion formed therein between the first and second ends. The cutout portion partitions the body into a first region, a second region, and a thin region between the first and second regions. The cutout portion produces a thermal break between the first and second regions. The thermal break operates to guide a heat flow between the first and second regions through the thin region. A thermally conductive chromatography tube extends through the first, second, and thin regions from the first end to the second end of the body. The tube is in thermal communication with the body. A section of the tube may run in a transverse direction across the body in the thin region of the body. 1. A fluidic block , comprising:a thermally conductive body having a first end and a second end opposite the first end, the body having a cutout portion formed therein between the first and second ends, the cutout portion partitioning the body into a first region, a second region, and a thin region between the first and second regions, the cutout portion producing a thermal break between the first and second regions, the thermal break operating to guide a heat flow between the first and second regions through the thin region; anda thermally conductive chromatography tube extending through the first, second, and thin regions from the first end to the second end of the body, the tube being in thermal communication with the body.2. The fluidic block of claim 1 , wherein the tube is cast within the body.3. The fluidic block of claim 1 , wherein the tube is diffusion bonded within the body.4. The fluidic block of claim 1 , wherein a section of the tube runs in a transverse direction across the body in the thin region of the body.5. The fluidic block of claim 1 , further comprising a column fitting coupled to one end of the tube.6. The fluidic block of claim 1 , wherein the ...

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Номер записи: 83
03-03-2022 дата публикации

PRESSURE TRANSDUCER, SYSTEM AND METHOD

Номер: US20220065721A1
Автор: Bertone Gary W., Castagna Taylor J., Dumas Robert J.
Принадлежит:

Disclosed is a pressure transducer including a body made of a material having a first coefficient of thermal expansion, a fluidic inlet and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet. The pressure transducer further includes a strain gauge including a resistive element in operable contact with the body. At least a portion of the resistive element made of a material having a second coefficient of thermal expansion that is different from the first coefficient of thermal expansion of the body. Disclosed further is a pressure transducer including a filler body located in a fluidic cavity of the pressure transducer configured to reduce adiabatic thermal effects on a transducer body. Disclosed are systems and methods incorporating the pressure transducers described herein.

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Номер записи: 84
03-03-2022 дата публикации

Sample injector

Номер: US20220065825A1
Автор: Indranil Mitra
Принадлежит: Roche Diagnostics Operations Inc

A liquid chromatography (LC) system comprises an LC switching valve comprising a sample input port, aspiration pump port, needle seat port, waste port leading to a waste, LC pump port and an LC column port. A sample aspiration needle is fluidically connected to the sample input port via a sample receiving conduit, an aspiration pump is fluidically connected to the aspiration pump port. The LC system includes a needle seat fluidically connected to the needle seat port via a needle seat conduit, an LC column fluidically connected to the LC column port, and an LC pump fluidically connected to the LC pump port, for injecting the sample into the LC column when the sample aspiration needle is seated into the needle seat and when the LC pump port is fluidically connected to the needle seat port and the sample input port is fluidically connected to the LC column port.

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Номер записи: 85
03-03-2022 дата публикации

SAMPLE INJECTOR FOR LIQUID CHROMATOGRAPHY, PARTICULARLY FOR HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Номер: US20220065826A1
Автор: HOCHGRAEBER Hermann
Принадлежит:

A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop. 2. The method of claim 1 , wherein the sample loop includes a first connecting piece and a second connecting piece claim 1 , wherein the first connecting piece is connected to a first sample loop port of the injection valve and to the sample conveying device claim 1 , wherein the second connecting piece is connected to a second sample loop port of the injection valve and to the sample conveying device claim 1 , wherein the second connecting piece includes an intake segment and a feed segment claim 1 , wherein the intake segment and the feed segment are configured to be separated.3. The method of claim 1 , wherein in the PRESSURE COMPENSATION position claim 1 , i) first and second sample loop ports of the injection valve are closed so as to facilitate a pressurization of the sample loop claim 1 , and ii) first and second high-pressure ports of the injection valve are connected so as to operatively connect the high-pressure pump in fluid communication with the high-pressure fluidic path to the chromatography column claim 1 , the method further comprising:determining the compressibility ...

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Номер записи: 86
03-03-2022 дата публикации

Multi-dimensional liquid chromotography with second dimension having a variable flow rate

Номер: US20220065827A1
Автор: Konstantin Shoykhet, Stephan Buckenmaier
Принадлежит: AGILENT TECHNOLOGIES INC

A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems. The first system is configured for providing a first chromatographic separation of a sample fluid comprised in a first mobile phase and to provide a first effluent including at least a portion of the separated sample fluid. The second system is configured for providing a second chromatographic separation of at least a portion of the first effluent comprised in a second mobile phase. A control unit is configured to operate the first liquid chromatography system by maintaining a first flow rate of the first mobile phase substantially constant during the first chromatographic separation, and to operate the second liquid chromatography system during the second chromatographic separation according to a control value different from the second flow rate, so that a variation in the control value can lead to a variation in the second flow rate.

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Номер записи: 87
25-02-2021 дата публикации

POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME

Номер: US20210053025A1
Автор: Alsbaiee Alaaeddin, Alzate-Sanchez Diego, DICHTEL William R., Helbling Damian, Hinestroza Juan, Ling Yuhan, Smith Brian J., Xiao Leilei
Принадлежит:

A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance. 5. The mesoporous polymeric material of claim 2 , wherein the molar ratio of cyclodextrin moieties to aryl moieties ranges from about 1:1 to about 1:X claim 2 , wherein X is three times the average number of glucose subunits in the cyclodextrin moieties.6. The mesoporous polymeric material of claim 2 , wherein the cyclodextrin is selected from the group consisting of α- claim 2 , β- claim 2 , γ-cyclodextrin claim 2 , and combinations thereof.7. The mesoporous polymeric material of claim 2 , wherein the cyclodextrin moieties comprise β-cyclodextrin.8. The mesoporous polymeric material of claim 7 , wherein the cyclodextrin moieties comprise β-cyclodextrin and the ratio of β-cyclodextrin moieties to crosslinking moieties is 1:1 to 1:21.9. The mesoporous polymeric material of claim 2 , wherein the mesoporous polymeric material has a Brunauer-Emmett-Teller (BET) surface area of 50 m/g to 2000 m/g.10. The mesoporous polymeric material of claim 3 , wherein the molar ratio of cyclodextrin moieties to aryl moieties ranges from about 1:1 to about 1:X claim 3 , wherein X is three times the average number of glucose subunits in the cyclodextrin moieties.11. The mesoporous polymeric material of claim 3 , wherein the cyclodextrin is selected from ...

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Номер записи: 88
23-02-2017 дата публикации

METHOD AND APPARATUS FOR THE EQUILIBRATION OF A PACKED CHROMATOGRAPHY COLUMN

Номер: US20170050120A1
Автор: Davies Geoff, Jordan Steve, Rana Sunil
Принадлежит:

Disclosed is a method for equilibrating a chromatography column including the steps of (i) providing a mobile phase; and (ii) passing the mobile phase through a packed chromatography column; wherein the mobile phase includes two liquids, the proportions of which change as it is passed through the column. Also discussed are automated aspects of the method, as well as a system capable of performing such method. 113-. (canceled)14. A method for equilibrating a chromatography column including the steps of (i) providing a packed chromatography column; and (ii) passing a pressurized mobile phase through said column; wherein the mobile phase is obtained by combining at least two liquids , the proportions of which are varied as the mobile phase is passed through the column.15. A method according to claim 14 , wherein the variation of said at least two liquids is achieved by combining an increasing proportion of one liquid and a decreasing proportion of another liquid to provide a linear gradient in the mobile phase as it passes the column.16. A method according to claim 14 , wherein at least one of the liquids is an organic solvent.17. A method according to claim 14 , where the mobile phase is passed through the column at a flow rate in the range of 10-200 ml/min.18. A method according to claim 14 , wherein the column is packed with a media.19. A method according to claim 14 , wherein the surface area of the packing available to the mobile phase is at least 500 m/g (dry weight) or greater.20. A method according to claim 14 , wherein the column and/or the column frits are made of a polymeric material claim 14 , such as polypropylene or polyethylene.21. A method according to claim 14 , wherein the size and material of the column as well as the packing surface area available to the mobile phase are used as parameters to define an equilibration gradient comprised of two liquids claim 14 , the proportions of which are varied as the mobile phase is passed through the column claim ...

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Номер записи: 89
14-02-2019 дата публикации

METHOD FOR ANALYZING BY-PRODUCTS OF RNA IN VITRO TRANSCRIPTION

Номер: US20190049414A1
Автор: RAPTOPOULOU Kiriaki, REICHERT Isabel, WOCHNER Aniela
Принадлежит:

The present invention relates to the detection and analysis of by-products in a process of RNA in vitro transcription by HPLC. It further relates to the use of this method for the quality control of RNA produced by in vitro transcription or for identifying suitable RNA purification conditions. 1. Method for detecting by-products of in vitro transcription in a sample comprising an in vitro transcribed target RNA , the method comprising the steps of:a) preparing a sample comprising a target RNA by in vitro transcription;b) purifying the target RNA, thereby providing a purified target RNA sample;c) detecting the by-products in the purified target RNA sample by HPLC.2. Method according to claim 1 , wherein the method does not comprise a step of treating the target RNA with a ribozyme.3. Method according to or claim 1 , wherein the by-products comprise at least two nucleic acid molecules with different length.4. Method according to any one of the preceding claims claim 1 , wherein the by-products do not comprise the 3′ terminus of the target RNA.5. Method according to any one of the preceding claims claim 1 , wherein the by-products have a length of 5 to 500 nucleotides.6. Method according to any one of the preceding claims claim 1 , wherein the by-products are homooligomers of nucleotides claim 1 , short single-stranded RNAs claim 1 , double-stranded RNAs and/or DNA-RNA hybrids.7. Method according to any one of the preceding claims claim 1 , wherein step b) is performed under denaturing conditions.8. Method according to any one of the preceding claims claim 1 , wherein step b) comprises a step of purifying the target RNA by HPLC.9. Method according to any one of the preceding claims claim 1 , wherein step b) comprises a step of purifying the target RNA by reversed-phase HPLC.10. Method according to or claim 1 , wherein a porous reversed phase is used as stationary phase in the HPLC.11. Method according to claim 10 , wherein the porous reversed phase is a porous claim 10 ...

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Номер записи: 90
14-02-2019 дата публикации

METHOD TO INCREASE THE CHROMATOGRAPHIC RESOLUTION OF OLEFIN-BASED POLYMERS WITH DIFFERENT MICROSTRUCTURES

Номер: US20190049416A1
Автор: Cong Rongjuan, Hollis Cherry, Parrott Albert
Принадлежит:

A method increase of the Resolution Index (Rl) of a chromatogram generated from a polymer sample comprising at least two olefin-based polymers of different microstructures and/or at least two olefin-based polymer fractions of different microstructures. The method comprises separating the mixture on a low-porosity stationary phase and repeatedly cycling the sample-stationary phase through a series of cooling and heating stages with active eluent flow only during the cooling stages and during the last heating stage to elute the separated analytes off the column. 1. A method to increase of the Resolution Index (RI) of a chromatogram generated from a polymer sample comprising at least two olefin-based polymers of different microstructures and/or at least two olefin-based polymer fractions of different microstructures;said method comprising at least the following steps, and wherein one of A) or B) occurs:{'sub': 0', '0, 'A) n′=0, and steps d) and e) below are skipped, such that step f) follows step c), and wherein T3is greater than T1;'}B) n′ is an integer ≥1; steps d) and e) are not skipped; and steps d) and e) are repeated for n′>1;a1) dissolving the polymer sample in at least one solvent to form a polymer solution;{'sub': '0', 'a2) injecting at least a portion of the polymer solution onto a stationary phase at a temperature T1(in ° C.), and wherein no eluent flow through the stationary phase;'}{'sub': 0', '0', '0', '0', '0', '0, 'b) setting a constant eluent flow rate (FR) through the stationary phase, while simultaneously cooling the stationary phase at a cooling rate CR, to a minimum temperature T2(in ° C.), where T2T2, ...

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Номер записи: 91
25-02-2021 дата публикации

SYSTEM FOR MEASURING PROPERTIES OF MASS TRANSPORT BEHAVIOR IN MEMBRANE AND SOLUTIONS

Номер: US20210055199A1
Автор: CHANG Ji Woong, JANG Yoon Hyuk, Park Kiho, YANG Dae Ryook
Принадлежит: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Disclosed is a system for measuring mass transfer in a membrane and solutions. The system includes: a membrane module including a feed solution reservoir accommodating a feed solution f, a draw solution reservoir accommodating a draw solution d whose osmotic concentration is higher than that of the feed solution f, and a holder supporting a semipermeable membrane m arranged between the feed solution reservoir and the draw solution reservoir and whose performance is to be measured; a feed solution storage tank storing the feed solution f; and a feed solution supply pump supplying the feed solution f from the feed solution storage tank to the feed solution reservoir at a fixed flow rate corresponding to a water flux WF across the membrane m such that the water flux WF is maintained constant. 1. A system for measuring mass transfer in a membrane and solutions , comprising: a membrane module including a feed solution reservoir accommodating a feed solution , a draw solution reservoir accommodating a draw solution whose osmotic concentration is higher than that of the feed solution , and a holder supporting a semipermeable membrane arranged between the feed solution reservoir and the draw solution reservoir and whose performance is to be measured; a feed solution storage tank storing the feed solution; and a feed solution supply pump supplying the feed solution from the feed solution storage tank to the feed solution reservoir at a fixed flow rate corresponding to a water flux across the membrane such that the water flux is maintained constant.2. The system according to claim 1 , further comprising a supply pump pressure gauge measuring the pressure of the feed solution supply pump for supplying the feed solution.3. The system according to claim 1 , wherein the feed solution supply pump is a high-performance liquid chromatography (HPLC) pump.4. The system according to claim 1 , wherein the temperatures of the feed solution and the draw solution are maintained in the ...

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Номер записи: 92
25-02-2021 дата публикации

PRESSURE DECOUPLING FLUID DRIVE UNIT FROM FLOW PATH FOR PRESSURE ADJUSTMENT OF SAMPLE ACCOMMODATION VOLUME

Номер: US20210055269A1
Автор: Shoykhet Konstantin
Принадлежит:

An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit. The control unit is configured to control pressure decoupling of at least part of at least one of the fluid drive units from the flow path, and enable the partially pressure-decoupled fluid drive unit(s) to pressurize the sample accommodation volume before fluidically coupling the sample accommodation volume with the flow path and/or to de-pressurize the sample accommodation volume after fluidically coupling the sample accommodation volume with the flow path for preparing a subsequent intake of fluidic sample in the sample accommodation volume. 1. A sample separation apparatus for separating a fluidic sample , the sample separation apparatus comprising:a fluid drive arrangement comprising a plurality of fluid drive units for driving a mobile phase along a flow path to a sample separation unit;a sample accommodation volume configured to accommodate the fluidic sample and being configured to be selectively fluidically coupleable with the flow path or fluidically decoupleable from the flow path; and to pressurize the sample accommodation volume before fluidically coupling the sample accommodation volume with the flow path; and/or', 'to de-pressurize the sample accommodation volume after fluidically coupling the sample accommodation volume with the flow path, for preparing a subsequent intake of fluidic sample in the sample accommodation volume., 'a control unit configured to control a pressure decoupling of at least part of at least one of the fluid drive units from the flow path in one operation mode of the sample separation apparatus and configured to enable the at least one at least partially pressure-decoupled fluid drive ...

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Номер записи: 93
25-02-2021 дата публикации

TWO-DIMENSIONAL LIQUID CHROMATOGRAPH SYSTEM

Номер: US20210055270A1
Автор: HAYAKAWA Yoshihiro, II DA Tetsuo, WATABE Yoshiyuki
Принадлежит: SHIMADZU CORPORATION

A two-dimensional liquid chromatograph system includes a first dimension analysis part, a second dimension analysis part, a second dimension feeding device, a fraction introduction part, a shift gradient program creation part, a liquid feeding control part, and a shift timing adjustment part. The shift gradient program creation part is configured to create a shift gradient program for causing the second dimension feeding device to execute shift gradient liquid feeding. The shift timing adjustment part is configured to adjust a shift timing to each stage in the shift gradient program created by the shift gradient program creation part based on a preliminary chromatogram acquired by the first dimension detector before the series of analysis operations for the sample to be analyzed. 1. A two-dimensional liquid chromatograph system comprising:a first dimension analysis part that includes a first dimension analysis channel through which a mobile phase for first dimension analysis flows, a sample injection part configured to inject a sample into the first dimension analysis channel, a first dimension analysis column provided on the first dimension analysis channel to separate a sample injected by the sample injection part into each component, and a dimension detector provided downstream of the first analysis column on the first analysis channel to acquire a chromatogram based on an eluate from the first dimension analysis column;a second dimension analysis part that includes a second dimension analysis channel, a second dimension analysis column provided on the second dimension analysis channel, and a second dimension detector for detecting components separated in the second dimension analysis column;a second dimension feeding device for feeding a mobile phase for second dimension analysis in the second dimension analysis channel;a fraction introduction part configured to divide an eluate from the first dimension analysis column into a plurality of modulations and to ...

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Номер записи: 94
13-02-2020 дата публикации

MICRO GAS CHROMATOGRAPHY SYSTEM

Номер: US20200049673A1
Автор: Lee Jang Hyeon, LEE Jun Suk, LIM Si-Hyung
Принадлежит:

Disclosed is a micro gas chromatography system including a fluid feeder for feeding a fluid composed of a carrier gas and a gas mixture containing an analyte component to the next stage, a micro gas preconcentrator chip configured to concentrate and desorb the analyte component contained in the fluid, a micro gas chromatography chip including a micro separation column for separating the analyte component concentrated and desorbed by the micro gas preconcentrator chip, and a micro sensing unit including a micro thermal conductivity detection sensor configured to detect the analyte component separated by the micro gas chromatography chip. 1. A micro gas chromatography system comprising:a fluid feeder configured to feed a fluid composed of a carrier gas and a gas mixture containing at least one analyte component to a micro gas preconcentrator chip;the micro gas preconcentrator chip configured to concentrate and desorb the analyte component contained in the fluid composed of the carrier gas and the gas mixture;a micro gas chromatography chip into which the fluid containing the analyte component desorbed from the micro gas preconcentrator chip is introduced and from which the analyte component contained in the fluid is separately eluted; anda micro sensing unit including a gas detector configured to detect the analyte component eluted from the micro gas chromatography chip,wherein the micro gas chromatography chip includes a micro separation column having a rectangular, circular, or serpentine micro-channel formed in one surface of a substrate, the micro-channel having a plurality of bumps formed on an inside wall surface thereof, wherein some of the bumps are formed on a first side of the inside wall surface of the micro-channel, the other bumps are formed on a second side that is opposite to the first side, and the bumps formed on the first side and the bumps formed on the second side are alternate with each other.2. The micro gas chromatography system according to ...

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Номер записи: 95
22-02-2018 дата публикации

ARTIFACT COMPENSATION DUE TO DIFFERENT PROPERTIES OF FLUID ACCOMMODATION VOLUMES IN SAMPLE SEPARATION APPARATUS

Номер: US20180052141A1
Автор: Buckenmaier Stephan, Shoykhet Konstantin, Stoll Dwight Robert, Witt Klaus
Принадлежит:

A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes. 1. A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample , the sample separation apparatus comprising at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample , wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the at least two fluid accommodation volumes.2. The control device according to claim 1 , wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts originating from an operation mode of the sample separation apparatus in which partial flows of fluids accommodated in at least two of the at least two fluid accommodation volumes are combined for subsequent separation.3. The control device according to claim 1 , wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts by claim 1 , in accordance with the different flow through properties claim 1 , adjusting a timing of start and/or end of introduction of fluidic ...

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Номер записи: 96
05-03-2015 дата публикации

COLUMN OVEN AND LIQUID CHROMATOGRAPH

Номер: US20150059450A1
Автор: TAKAHASHI Kazuya
Принадлежит: SHIMADZU CORPORATION

A column oven includes a main unit, an auxiliary unit, an outside sensor, an internal sensor, a temperature range holding section for holding a plurality of temperature ranges, a temperature range specifying portion for specifying the temperature range to which the outside temperature belongs, a temperature control program holding section for holding a temperature control program for a control method of the main unit and the auxiliary unit in each temperature range in such a way that outputs of the main unit and the auxiliary unit are continuous in the temperature ranges that are adjacent to each other, a control method setting portion for setting a control method of the main unit and the auxiliary unit based on the temperature range specified and the temperature control program, and a temperature control portion for controlling the main unit and the auxiliary unit. 1. A column oven comprising:a housing including inside a temperature adjusting space for accommodating an analytical column;a main unit for heating and cooling the analytical column in the temperature adjusting space;an auxiliary unit, provided separately from the main unit, for heating the analytical column in the temperature adjusting space;an outside sensor for detecting an outside temperature that is a temperature outside the housing;an internal sensor for detecting an inside temperature that is a temperature inside the temperature adjusting space;a set temperature holding section for holding a set temperature that is a target value of a temperature of the analytical column;a temperature range holding section for holding a plurality of continuous temperature ranges in a temperature scope in which the outside temperature possibly changes;a temperature range specifying portion for specifying, among the temperature ranges of the temperature range holding section, the temperature range to which the outside temperature detected by the outside sensor belongs;a temperature control program holding section ...

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Номер записи: 97
05-03-2015 дата публикации

Modular solenoid valve kits and associated methods

Номер: US20150059865A1
Автор: Joshua A. Shreve, Paul Keenan, Steven D. Trudeau
Принадлежит: Waters Technologies Corp

Exemplary embodiments are directed to modular solenoid valve kits and associated methods, generally involving a valve body that includes a plurality of actuator section components and a plurality of head section components. The plurality of actuator section components includes a drive solenoid, a solenoid return spring, a stroke calibration collar and an actuator-to-head calibration collar. The plurality of head section components includes a needle, a stem return spring, a seal and a seat. The plurality of actuator section components and head section components are adapted to be interchanged to create a pull-through normally open valve, a pull-through normally closed valve, a push-in normally open valve and a push-in normally closed valve. That is, the kits and methods allow for modification of one valve type (e.g., a pull-through normally open valve, a pull-through normally closed valve, a push-in normally open valve and a push-in normally closed valve) into a different type.

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Номер записи: 98
10-03-2022 дата публикации

HEATER INTEGRATED GAS CHROMATOGRAPHY COLUMN DEVICE

Номер: US20220074898A1
Автор: AHN Jong Rok, KIM Jae-Ha, Kim Taeman, Park Han-Oh
Принадлежит:

A heater integrated gas chromatography (GC) column device according to the present invention is capable of precisely and uniformly controlling a temperature by having a high thermal conductivity, and raising and lowering a temperature at a high speed by having a low thermal mass, such that a measuring time is significantly decreased. The GC column is in contact with a bobbin with a homogeneous temperature distribution, and thus a temperature is homogeneously distributed in each GC column. Further, the heater integrated GC column device according to the present invention has the above-described effects and may have a smaller size. 1. A heater integrated gas chromatography (GC) column device comprising:a bobbin formed of a metal having a high thermal conductivity;an insulating layer including a metal oxide film formed on an inner surface of the bobbin;a heat generating layer bonded to the insulating layer and including any one or more selected from the group consisting of carbon nanotubes and a carbon nanotube-metal composite;a metal electrode formed to be in contact with the heat generating layer; anda GC column wound around the bobbin while being adjacent to an outer surface of the bobbin.2. The heater integrated GC column device of claim 1 , further comprising a bonding layer formed between the outer surface of the bobbin claim 1 , and the GC column.3. The heater integrated GC column device of claim 2 , wherein the bonding layer is formed of a heat-resistant silicone or an epoxy resin.4. The heater integrated GC column device of claim 2 , wherein an average thickness of the bonding layer is 10 to 500 μm.5. The heater integrated GC column device of claim 1 , wherein the metal having a high thermal conductivity is selected from the group consisting of copper claim 1 , magnesium claim 1 , aluminum and alloys thereof.6. The heater integrated GC column device of claim 1 , wherein the insulating layer is a metal oxide film formed by anodizing the inner surface of the ...

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Номер записи: 99
10-03-2022 дата публикации

LIQUID CHROMATOGRAPH MASS SPECTROMETER

Номер: US20220074901A1
Автор: Hashimoto Yuichiro, SUMIGAMA Yuka
Принадлежит:

The invention provides a liquid chromatograph mass spectrometer which prevents contamination of a pump and a column and can perform mass calibration without adding a complicated mechanism. This liquid chromatograph mass spectrometer includes a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent, a mass spectrometer configured to analyze a mass of a sample, and a standard sample container configured to be connected in series with the liquid chromatograph and the mass spectrometer in a flow path that connects the liquid chromatograph and the mass spectrometer and configured to house a standard sample for mass calibration. 1. A liquid chromatograph mass spectrometer , comprising:a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent;a mass spectrometer configured to analyze a mass of a sample; anda standard sample container configured to be installed in a flow path connecting the liquid chromatograph and the mass spectrometer, configured to be connected in series with the liquid chromatograph and the mass spectrometer, and configured to house a standard sample for mass calibration.2. The liquid chromatograph mass spectrometer according to claim 1 , wherein a cylindrical case that includes an injection hole at a first end and a discharge hole at a second end and that has a flow path direction as a longitudinal direction, and', 'a partition plate configured to be movable along an inner wall of the case and partitioning an inside of the case, and wherein, 'the standard sample container includesthe partition plate is configured to be movable in a direction of the discharge hole due to movement of a mobile phase solution from the injection hole.3. The liquid chromatograph mass spectrometer according to claim 1 , wherein a case that includes an injection hole at a first end and a discharge hole at a second end, and', 'a tube connected between the injection hole and the discharge hole in the case ...

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Номер записи: 100