28-11-2013 дата публикации
Номер: US20130313483A1
Принадлежит:
A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one phase comprises a polymer, wherein the phases, taken together, represent a density gradient. Novel two-phase, three-phase, four-phase, five-phase, or six-phase systems are disclosed. Using the disclosed multi-phase polymer systems, particles, or other analyte of interest can be separated based on their different densities or affinities. 1. A multi-phase system , comprising: each of the first and second phases comprises a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof, wherein at least one of the first and second phases comprises a polymer;', 'each said phase has an upper and a lower phase boundary; and', 'each of the two or more phases has a different density and the phases, taken together, represent a density gradient; and, 'two or more phase-separated phases including at least a first and second phases, wherein'}an analyte contained within the phase-separated solution, wherein the analyte is located predominantly at one of the phase boundaries.2. The multi-phase system of claim 1 , wherein greater than 80% of the analyte is located at one or more of the phase boundaries.3. The multi-phase system of claim 1 , wherein greater than 90% of the analyte is located at one or more of the phase boundaries.4. The multi-phase system of claim 1 , wherein the system comprises more than one analyte and the additional analytes are located at the same or different phase boundary.5. A multi-phase system claim 1 , comprising: each phase comprises a phase component selected from the group consisting of a polymer, a surfactant and combinations thereof,', 'wherein at least one phase comprises a polymer; and', 'each of the two or more phases has a different density and the phases, taken together, ...
Подробнее