Впускное отверстие масс-спектрометра с уменьшенным средним потоком

Изобретение относится к области масс-спектрометрии. Интерфейс выполнен с возможностью переноса ионов, созданных при давлении, равном или близком к атмосферному давлению, в масс-спектрометр для массового анализа. Интерфейс содержит первый канал с впускным отверстием, выполненным с возможностью приема текучей среды, содержащей ионы, и с выпускным отверстием, выполненным с возможностью направления текучей среды, содержащей ионы, в масс-спектрометр. Первый канал имеет первый проточный тракт, проходящий от впускного отверстия к выпускному отверстию. Интерфейс содержит насос. Интерфейс содержит второй канал. Второй канал содержит впускное отверстие. Второй канал формирует второй проточный тракт, проходящий от места между впускным отверстием и выпускным отверстием первого канала к выпускному отверстию второго канала. Насос выполнен с возможностью отведения части текучей среды, содержащей ионы, протекающей в первом проточном тракте, ко второму проточному тракту. Технический результат - упрощение ...

СПОСОБ ПЕРЕНОСА ИОНОВ, ИНТЕРФЕЙС, ВЫПОЛНЕННЫЙ С ВОЗМОЖНОСТЬЮ ПЕРЕНОСА ИОНОВ, И СИСТЕМА, СОДЕРЖАЩАЯ ИСТОЧНИК ГАЗООБРАЗНЫХ ИОНОВ

Eine GC/MS-Anordnung und Massenspektrometer

GC/MS-Anordnung, umfassend: eine GC-Einheit; eine MS-Einheit; eine Transferleitung, die die GC-Einheit und die MS-Einheit strömungsmäßig verbindet; ein Trägergasventil zum selektiven Zuführen von Trägergas zu der Transferleitung; mindestens eine Überwachungseinheit, die der MS-Einheit zugeordnet ist, zum Überwachen mindestens eines Betriebszustands der MS-Einheit; und eine Steuerung, die mit der mindestens einen Überwachungseinheit und dem Trägergasventil verbunden und so konfiguriert ist, dass sie das Trägergasventil schließt, wenn ein vorbestimmtes Betriebsereignis von der mindestens einen Überwachungseinheit erfasst wird.

Verfahren und Vorrichtung zum Nachweis von Probenmolekülen in einem Trägergas

VORRICHTUNG ZUR ZUFUEHRUNG EINER GASPROBE ZU EINEM HOCHVAKUUMBEHAELTER

Mass spectrometry device

The present invention relates to a mass spectrometry device that can perform highly robust, highly sensitive, and low-noise analysis. The present invention addresses the problems of preventing reductions in ion transfer efficiency and of suppressing the introduction of noise components from droplets, etc. The present invention has an ion source that generates ions, a vacuum chamber that is evacuated by an evacuation means and that is for analyzing the mass of ions, and an ion introduction electrode (12) that introduces ions into the vacuum chamber. The present invention is characterized in that the ion introduction electrode (12) has an ion-source-side front-stage pore (35), a vacuum-chamber-side rear-stage pore (36), and an intermediate pressure chamber (33) that is between the front-stage pore (35) and the rear-stage pore (36), in that the cross-sectional area of an ion inlet of the intermediate pressure chamber (33) is larger than the cross-sectional area of the front-stage pore (35) ...

CHEMICAL ANALYTICAL APPARATUS

... 1366629 Gas chromatography C N GOODE C J THOMPSON and E W HORTON 29 Feb 1972 [1 Dec 1970] 56916/70 Heading B1H A chemical analytical instrument includes a pair of gas chromatographic columns, a mass spectrometer having an inlet port, piping interconnecting each gas chromatographic column individually to the said inlet port, a vent tube, piping interconnecting each gas chromatographic column individually to the vent tube and valve means whereby each gas chromatographic column may be selectively connected for throughflow of gas, either to the mass spectrometer or to the vent tube. While one column is being purged of the remains of a sample the other may be used for the next sample; more than two such columns may be so connected.

A GC/MS arrangement and mass spectrometer

Gas inlet for a process mass spectrometer

Improvements relating to method of and apparatus for providing successive small quantities of gas

... A method of dispensing a small quantity of gas at predetermined volume and pressure, comprises filling a metering chamber 1 with gas, balancing the gas pressure against a displaceable column of liquid 3, causing excess gas to spill into an evacuated chamber or duct 5, and delivering the gas so obtained to apparatus such as analysing apparatus. To charge the chamber 1, a duct 4 is closed and a supply pipe 14 brought into temporary communication with the end of a duct 12 in a tank of sealing liquid 13. The incoming gas depresses the level of the liquid 3 in the chamber 1 and raises it in a closed tube 2 until the lower end of the duct 5 is uncovered. At this stage, the supply of gas is arrested and excess gas pumped away through a duct 6 until the liquid level in the chamber reaches the lower end of the duct 5. The gas sample is then delivered by opening the duct 4. The pressure of the sample may be varied by adjustment of a screw 11 which governs ...

Gas mixing system for >an> ion source

A gas mixing system is used to mix an analyte gas with a carrier gas before ionization of the mixed gas. The ionized mixed gas may then be supplied to a mass spectrometer. A discrete volume 21 of a sample gas is supplied at a first, relatively low pressure to a mixing chamber 37. A mixer gas 18 at a higher pressure is mixed with the sample gas in the mixing chamber 37. The output of the mixing chamber is a mixed gas at a pressure higher than the first pressure and is supplied to an ionization device 50. After supplying a sample to the ionisation device, the mixing chamber can be purged using a vacuum system 32, 35. The system is particularly suited for use with uranium hexafluoride as the sample gas and an inert gas such as argon as the mixer gas.

Ion modification

An ion mobility spectrometer comprises a sample inlet 108 with an aperture to allow a sample of gaseous fluid to flow from an ambient pressure region to a low pressure region 103 to be ionised. A controller 200 controls gas pressure in the low pressure ionisation region to be lower than ambient pressure. An ion modifier modifies ions in the low pressure ionisation region. The ion modifier may comprise two electrodes (126, 127) spaced apart wherein the electrodes each comprise a grid of conductors. The ion modifier electrodes may modify ions by subjecting ions to an alternating RF electric field. The ion modifier may fragment parent ions into daughter ions by causing ions to experience a collision with high enough energy for a bond to break.

Targeted analysis for tandem mass spectrometry

A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source (10) and an ion injector (21, 23) injects ions towards a downstream ion guide (50, 60) via a single or multi reflection TOF device (30) that separates ions into packets in accordance with their m/z. A single pass ion page (40) in the path of the precursor ions between the ion injector (21, 23) and the ion guide (50, 60) is controlled so that (only a subset of precursor ion packets, containing precursor ions of interest, is allowed onward transmission to the ion guide (50, 60). A high resolution mass spectrometer (70) is provided for analysis of those ions, or their fragments, which have been allowed passage through the ion gate (40). The technique permits multiple m/z ranges to be selected from a wise mass range of precursors, with optional fragmentation of one or more of the chosen ion species.

An interface probe

A gas chromatography interface probe 100 comprises a copper inner tube 104 in a heated transfer line. A stainless steel GC fitting (150, Fig 7) may be secured to a first end of the inner tube and may comprise a flat portion 153 so that the fitting moves linearly with respect to GC end cap 112. An analyser cap 110 comprising a non-planar wall may be provided at the second end of the inner tube. The inner tube may be associated with a heating element and surrounded by three outer tubes 105, 106, 155. The heated transfer line may be translatably received in a housing 107 and may comprise a locking collar 113 rotatably mounted with respect to the housing. A mounting flange 115 may secure the interface to a plinth in use. The inner tube may be mounted with respect to the mounting flange with a floating or movable connection. A gas fitting (200, Fig 12) may be provided wherein the diameter of the central bore of the fitting is less than or equal to the diameter of the bore of the inner tube.

Ion source

Gas inlet system for isotope ratio analyser

A gas inlet system for an isotope ratio analyser comprising: at least a supply of each of a reference gas, a sample gas and a carrier gas for diluting the reference gas or sample gas, one or more T-junctions for allowing the carrier gas to dilute the reference gas or sample gas, and one or more separate T-junctions having an opening to atmosphere. The T-junctions may be machined channels in a mechanical block and the opening preferably comprises an open capillary.

Spectrometric analysis

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications.

Probe adaptor assembly

An apparatus (Fig. 6, 200) suitable for connecting an ionisation probe assembly (110) to a mass and/or ion mobility spectrometer comprising an attachment member 122 for releasably attaching, screw fitting 231, a probe assembly (110) to the apparatus (200). A cap 240 for enclosing the attachment member 122 is provided which is configurable to enclose the attachment member 122 when a probe assembly (110) is attached to the apparatus. The cap 240 also has an aperture 241 through which at least a portion of the probe assembly 118 can pass. A device, such as a ball bearing 242, is used to close the aperture 241 when the cap 240 encloses the attachment member 122 and when no probe assembly (110) is attached to the apparatus. This prevents contact with the attachment member 122 when the probe assembly (110) is not attached to the apparatus (200) and the cap 240 is closed.

Transfer line, GCMS arrangement

Improvements in or relating to mass spectrometers

A portable mass spectrometer comprises a power pack C and a hand held probe P, the probe comprising a gas inlet 13 with a porous membrane 14, an ion source 15 which can also function as an ion pump, a quadrupole ion filter 16, an ion detector 17 and a chemical getter G to provide a vacuum within the probe. The spectrometer is intended for detecting chemicals in remote areas and does not require a conventional vacuum system. Valves 12 and 21 are provided on the probe P and getter G respectively, both valves being opened when these two parts are engaged. ...

Mass spectrometer system

Collision surface for improved ionisation

Spectrometric analysis

FLYING TIME MASS SPECTROMETER WITH GASEOUS PHASE ION GUN, WITH HIGH SENSITIVITY AND LARGE ONE DYNAMIC RANGE

ARRANGEMENT FOR CONNECTING A LOW PRESSURE ENTRANCE OF GAS ANALYSIS EQUIPMENT

Sample analysis apparatus having improved input optics and component arrangement

The present invention relates to generally to components of scientific analytical equipment. More particularly, the invention relates to instruments such as mass spectrometers that rely on ion detectors and modifications thereto for extending the operational lifetime or otherwise improving performance. The invention may be embodied as a sample analysis apparatus comprising: an ion source configured to generate an ion from a sample input into the particle detection apparatus, and an ion detector having an input configured to receive an ion generated from an ion source, wherein the sample analysis apparatus is configured such that a contaminant comingling with an ion generated by the ion source and flowing in the same general direction as the ion, is inhibited or prevented from entering the detector input.

Method for predicting chemical or physical properties of complex mixtures

CAPILLARY VALVE THAT CAN BE PULSED

The invention relates to a capillary valve that can be pulsed and to the use thereof. The aim of the invention is to configure the capillary valve in such a way that said valve is suitable for small sample quantities, whereby said valve can be pulsed. The aim of the invention is also to provide a use for said capillary valve. A capillary (1) which has a narrowed section that is embodied as a nozzle (2), a tappet (3) that is situated in said capillary, can be moved therein and, together with the narrowed section of the capillary, can form a sealing as well as a drive for the tappet (8) are provided. The invention also relates to the use of the capillary valve as a gas supply for an ion source or as a gas supply for a UV/fluorescence cell, whereby said valve can be pulsed.

FLOWMETER FOR PROVIDING SYNCHRONIZED FLOW DATA AND RESPIRATORY GAS SAMPLES TO A MEDICAL MASS SPECTROMETER

Respiratory gas flow data is synchronously provided along with continuous samples of the gases for analysis by a medical mass spectrometer. The gas flow data is determined by use of the differential pressure across a resistive core in a sampling flowmeter and the flow value at any instant is registered by proportionately admitting a non-toxic gas that is foreign to the normal respiratory gases into the sampling inlet in a quantity controlled by the differential pressure. The quantity of foreign gas therefore represents flow and is drawn through the inlet tube in exact synchronism with its corresponding respiratory gas sample for analysis by the spectrometer. The generated signal representing the amount of foreign gas, hence the flow, may then be used with the signals representing concentration of the various gases in the corresponding respiratory gas sample to calculate various medical parameters, such as oxygen uptake, where the exact synchronism of these signals is important.

RESPIRATORY GAS MOISTURE SEPARATOR SYSTEM FOR MASS SPECTROMETER MONITORING SYSTEMS

THERMAL DESORPTION TUBE SAMPLER

The disclosure provides a thermal desorption (TD) tube sampler. The sampler comprises a first connector configured to reversibly connect to a TD tube containing a sample, and a second connector configured to couple to a direct injection mass spectrometer. The TD tube sampler is configured to desorb a sample in a TD tube connected thereto, and feed the desorbed sample from the TD tube to a direct injection mass spectrometer such that the desorbed sample does not pass through a cold trap.

OFF-AXIS IONIZATION DEVICES AND SYSTEMS

An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.

TISSUE ANALYSIS BY MASS SPECTROMETRY OR ION MOBILITY SPECTROMETRY

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

A DUAL SOURCE MASS SPECTROMETRY SYSTEM

In or for a dual source mass spectrometry system (10), an ion source housing (16) for detachable connection to a mass spectrometer of the system. The ion source housing comprises a source chamber (22) having an outlet port for connection to a vacuum region of a mass spectrometer, a sample port for receiving a gas chromatography [GC] column and means for charging analyte molecules discharged from said GC column, wherein the housing comprises a docking means by which a GC interface probe can be releasably engaged with the housing.

SAMPLE INTRODUCING APPARATUS AND SAMPLE MODULES FOR MASS SPECTROMETER

An apparatus (10) for introducing gaseous samples from a wide range of environme ntal matrices into a mass spectrometer (14) for analysis of the samples is described. Several sample preparing modules (30) including a real-time air monitoring module (94), a soil/liquid purge module (136), and a thermal desorption module (162) ar e individually and rapidly attachable to the sample introducing apparatus (10) for supplying gaseous samples to the mass spectromete r (14). The sample-introducing apparatus (14) uses a capillary column (24) for conveying the gaseous samples into the mas s spectrometer (14) and is provided with an open/split interface (32) in communication with the capillary (24) and a sample archiving port (70) through which at least about 90 percent of the gaseous sample in a mixture with an inert gas that was introdu ced into the sample introducing apparatus (10) is separated from a minor portion of the mixture entering the capillary (24) discha rged from the sample introducing ...

Procédé pour l'introduction d'un échantillon à l'état de gaz ou de vapeur dans un appareil d'analyse, un spectromètre ou un autre appareil d'examen fonctionnant sous pression réduite, et dispositif pour sa mise en oeuvre

Procédé et installation de dosage du deutérium dans les composés hydrogènes

ANALYSIS DEVICE WITH GAS CHROMATOGRAPH AND MASS SPECTROMETER.

SOURCE OF ION BEAM FOR THE PRODUCTION OF AN ION BEAM OF VARIABLE ENERGY.

DEVICE FOR THE DECREASE OF THE CONTENT AT LIQUID DROPLETS IN AN INHALED GAS SAMPLE, WHICH IS SUCKED TO ANALYSIS INTO A CAPILLARY TUBE.

DEVICE FOR FLOW MEASUREMENT WITH A MASS SPECTROMETER.

СПОСОБ И УСТРОЙСТВО ДЛЯ АНАЛИЗА ФЛЮИДОВ В СКВАЖИНЕ С ОПРЕДЕЛЕНИЕМ ХАРАКТЕРИСТИК ПЛАСТОВЫХ ФЛЮИДОВ

Предлагается вводить пробу пластового флюида в контакт с жестко опертой полупроницаемой мембраной, такой как мембрана из силиконового каучука, которая позволяет газам и парам диффундировать из пластового флюида в вакуумную камеру, в то же время задерживая любые жидкости. В вакуумной камере прошедший через мембрану газ анализируется анализатором остаточных газов. Для поддержания вакуума в вакуумной камере с последней связан ионный насос или сорбент. Ионный насос или сорбент удаляет из камеры газы и пары, диффундирующие в камеру из пробы пластового флюида, находящейся с противоположной стороны полупроницаемой мембраны.

СПОСОБ И УСТРОЙСТВО ДЛЯ АНАЛИЗА ФЛЮИДОВ В СКВАЖИНЕ С ОПРЕДЕЛЕНИЕМ ХАРАКТЕРИСТИК ПЛАСТОВЫХ ФЛЮИДОВ

Предлагается вводить пробу пластового флюида в контакт с жестко опертой полупроницаемой мембраной, такой как мембрана из силиконового каучука, которая позволяет газам и парам диффундировать из пластового флюида в вакуумную камеру, в то же время задерживая любые жидкости. В вакуумной камере прошедший через мембрану газ анализируется анализатором остаточных газов. Для поддержания вакуума в вакуумной камере с последней связан ионный насос или сорбент. Ионный насос или сорбент удаляет из камеры газы и пары, диффундирующие в камеру из пробы пластового флюида, находящейся с противоположной стороны полупроницаемой мембраны.

TURBO MOLECULAR PUMP FOR MASS SPECTROMETER

Apparatus for the introduction of a sample into a mass spectrometer

FLOWMETER INTENDS TO PROVIDE, IN SYNCHRONISM, HAS A SPECTROMETER, RELATIVE DATA WITH THE FLOW AND RESPIRATORY GAS SAMPLES

Focusing ionization device and mass spectrometer

The present invention provides a focusing ionization device which includes a ball having a surface with a plurality of dimples, and a corona discharge needle located at a side of the ball. The focusing ionization device is adapted for being disposed inside a mass spectrometer in a way that the ball is located at a spray path of gaseous analytes and the corona discharge needle is adjacent to an inlet of a mass analyzer. When the gaseous analytes pass through the ball, the gaseous analytes can be gathered around the corona discharge needle and then ionized into analyte ions, which in turn flow into the mass analyzer. Therefore, the focusing ionization device of the present invention can effectively enhance the amount of the analyte ions which flow into the mass analyzer, thereby improving ion transmission efficiency, increasing signal intensity, lowering the limit of detection (LOD), and minimizing the error of detection.

Controlled separation of laser ablation sample gas for direction to multiple analytic detectors

A laser-ablation-based analytical system can include a sample chamber input, a make-up gas input, a vacuum pump, and an output flow. The sample chamber input can be configured to deliver a sample chamber gas flow comprised of combination of a laser-ablated sample and a sample-carrier gas from a sample chamber. The make-up gas input can be configured to provide an amount of make-up gas to supplement the combination of the laser-ablated sample and the sample-carrier gas. The vacuum pump can be fluidly connected to the sample chamber input and the make-up gas input, the vacuum pump configured to create a negative pressure in a sample transport gas downstream of the vacuum pump, the sample transport gas including the make-up gas, the laser-ablated sample, and the sample-carrier gas. The output flow can be configured to deliver the sample transport gas from the vacuum pump to a detection device.

GAS PURIFICATION DEVICE, AND APPARATUS AND METHOD FOR MEASURING NOBLE GAS ISOTOPES

Disclosed are a gas purification device, and an apparatus and a method for measuring isotopes of noble gases. The gas purification device includes a housing and a purification mechanism. The housing is provided with a reaction chamber. The reaction chamber is in a vacuum state and is configured to hold a gas sample. The purification mechanism is arranged on the housing and is provided with a cavity. The cavity in the purification mechanism is communicated with the reaction chamber. The purification mechanism is configured to purify the gas sample in the reaction chamber to obtain a purified gas.

DEVICE FOR PREVENTING INTENSITY REDUCTION OF OPTICAL SIGNAL, OPTICAL EMISSION SPECTROMETER, OPTICAL INSTRUMENT, AND MASS SPECTROMETER INCLUDING THE SAME

A device for a device for preventing the intensity reduction of an optical signal, an optical emission spectrometer, an optical instrument, and a mass spectrometer including the same are provided. The device for preventing the intensity reduction includes a shielding filter which has a mesh structure capable of blocking RF electromagnetic waves radiated from a plasma field for a wafer processing, is installed in the front of an optical window of an optical emission spectrometer for measuring the plasma field from an emission spectrum image of the plasma field, and collects charging particles passing through the mesh.

Systems and methods for transfer of ions for analysis

The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

Gas chromatograph-ion mobility spectrometer system

A GC-IMS system is disclosed. The system includes a sample transfer device. The sample transfer device connects the gas chromatograph to the reaction region and, the sample from the gas chromatograph is transferred to the reaction region by the sample transfer device. With the GC-IMS system, generation of sample molecular ion fragments can be avoided so that the spectrum is easily identified; moreover, the application field of the GC-IMS system is extended to a range of analysis of organic macromolecule samples which have a high polarity, are difficult to volatilize, and are thermally instable. On the other hand, the GC-IMS system overcomes the defect of ion destruction due to neutralization reaction among positive and negative ions so as to evade the detection.

VAPOUR GENERATORS

A vapour generator system (1, 101) for an IMS (4, 104) or other apparatus has a chamber (9, 109) in which vapour is produced. A fan or other flow generator (6, 106) is connected to an inlet (8, 108) of the vapour chamber (9, 109) and its outlet (13, 113) is connected to an adsorbent passage (14, 114), such as formed by a bore through a block (15) of carbon. When the fan (6, 106) is on gas flows through the vapour chamber (9, 109) and the adsorbent passage (14, 114) to the IMS (4, 104) or other outlet, with little vapour being adsorbed in the passage. When the fan (6, 106) is off, any vapour molecules that escape to the adsorbent passage (14, 114) do so at a low rate such that substantially all is adsorbed and no vapour escapes.

Collision cell

A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

Real-time online monitoring and source apportionment method for atmospheric fine particles containing heavy metals

The present disclosure provides an online monitoring and source apportionment method for atmospheric particles containing heavy metals, and belongs to the technical field of online quantification and source tracing of atmospheric particles containing heavy metals. The single particle aerosol mass spectrometer and X-ray fluorescence spectrometer are combined to quickly determine the concentration, time series, chemical compositions and mixing state of atmospheric particles containing heavy metals from both qualitative and quantitative perspectives. A heavy metal-containing particle mass concentration limit system is incorporated into the X-ray fluorescence spectrometer. Once the mass concentration of a particle containing heavy metals exceeds the standard, the aerosol mass spectrometer can immediately receive this alert through the information transmission system. The online source tracing system of aerosol mass spectrometer will start immediately after receiving the signal of the heavy ...

Electron impact ion source for trace analysis

An apparatus for analyzing trace elements in a gas sample includes a feedback system (46, 64, 68, 70) for accurately regulating and sensing the pressure supplied to an ion chamber (32). The feedback system is capable of compensating for a wide range of input gas pressures from a source (36). The ion chamber (32) is a closed ion source which is resistant to corrosion and aids in the reduction of noise. An ion detector (34) is calibrated for accurately scaling the measurements of trace elements. Two filaments (96, 98) mounted outiside the ion chamber (32) adjacent apertures (90) in the chamber wall are thereby shielded from the ions. A quadrupole analyser (23) receives the ions through an aperture (88) and is shielded by the ion chamber (32) from electrons from the filaments (96, 98). The feedback system controls the pressure in a regulator module (46), thereby determining the ion chamber pressure through the pressure drop through the exit aperture (56) of the regulator module (46).

Apparatus comprising means for mass spectrometry

Sample introduction method and device for a mass spectrometer

Verfahren zur massenspektrometrischen Untersuchung gasförmiger Komponenten

Vorrichtung für die Aufbereitung eines Gasstromes vor der Zufuhr desselben zu einem Massenspektrometer

Die Erfindung betrifft eine Vorrichtung für die Aufbereitung eines Gasstromes vor der Zufuhr desselben zu einem Massenspektrometer, wobei der Gasstrom einen oder mehrere Analyten und als Trägergas Helium enthält. Erfindungsgemäß ist eine selektiv wirkende Trenneinrichtung zum Abtrennen eines Teils des Trägergases aus dem Gasstrom (10) und zur Bildung eines Restgasstromes (11) und eines hiervon abgetrennten Trägergasstromes (12) vorgesehen, wobei im Restgasstrom ein höherer Anteil des Analyten vorliegt als im Gasstrom und wobei im abgetrennten Trägergasstrom ein niedrigerer Anteil des Analyten vorliegt als im Gasstrom.

Massenspektrometersystem und Verfahren

Massenspektrometersystem, welches Folgendes aufweist:eine Massenspektrometrieeinheit (4), welche eine Massenauswahl und -trennung einer lonenspezies mit einem spezifischen Masse-/Ladungsverhältnis m/z ausführt durch Anlegen einer Gleichspannung U und einer Hochfrequenzspannung Vcos Ωt mit einer Amplitude V und einer Winkelfrequenz Ω an eine Multipolelektrode (13), um ein elektrisches Multipolfeld zu erzeugen, Injizieren einer ionisierten Probe in das Multipolfeld und Einstellen und Steuern der an die Multipolelektrode (13) angelegten Spannung, so dass die Ionenspezies mit dem spezifischen Masse-/Ladungsverhältnis m/z durch die Multipolelektrode (13) hindurchtritt,eine lonendetektionseinheit (5), welche die lonenspezies detektiert,eine Datenverarbeitungseinheit (6), welche eine Ausgabe der Ionendetektionseinheit (5) verarbeitet, undeine Steuereinheit (8), welche die Massenspektrometrieeinheit (4) steuert,dadurch gekennzeichnet, dass die Steuereinheit (8) dazu ausgelegt ist, die Massenspektrometrieeinheit ...

Method and apparatus for measuring the permeation of gases and vapours through materials

Flow reduction system for isotope ratio measurements

Targeted analysis for tandem mass spectrometry

Ion mobility spectrometer system

Improved sample preparation apparatus and method for elemental analysis spectrometer

Methods and apparatus for guiding ions entrained within a gas

A guide apparatus for generating a flow of ions comprises an ion source 61 for providing ions within a gas at a source pressure. A vacuum chamber 63 is controllable to achieve a second pressure therein and comprises a gas inlet 62 having a first cross sectional area (a) arranged for jetting said gas containing entrained ions into the vacuum chamber along a predetermined jetting axis. A gas duct 67 comprising a duct bore having a second cross sectional area (A) is positioned coaxially with the jetting axis, in register with the gas inlet opening. The second pressure is controlled so as to form a supersonic free jet in the duct with a jet pressure ratio restrained to a value which does not exceed the cubed ratio (A/a)3 of the second and first cross sectional areas. As a result, the expansion of the free jet is restrained so as to form a subsonic laminar flow 71 within the gas duct for guiding entrained ions.

Liquid trap or separator for electrosurgical applications

Mass spectrometry system and method

Auxiliary gas inlet

A method and an apparatus for analyzing trace impurities in gases

System for introducing gas specimens into reduced pressure type analysers

... 1,059,755. Sampling gases. SOC. NATIONALE DES PETROLES D'AQUITAINE. July 19, 1965 [July 23, 1964], No.30648/65. Heading G1B. A device for introducing a gas sample into an analyzer, e.g. a mass spectrometer 6 comprises a capillary 8 connecting a source of the gas with a single intermediate chamber 9 which chamber is connected both to a vacuum pump 12 by way of a needle valve 11, and to the spectrometer 6 by way of a second capillary 10. A gauge 13 may be provided for monitoring the pressure in the chamber 9 and the spectrometer 6 is provided with its own pump 7 to draw the sample through the second capillary 10. The capillary 8 is of larger diameter than the capillary 10 and may be a metal tube, whereas the capillary 10 is preferably of molybdenum glass. The pressures in the capillaries and the chamber 9 are so arranged that the gas flow is turbulent and this ensures representative sampling. A practical construction of sampling device is described in the Specification.

Probe assembly connector

An ion shutter, a method of controlling ion shutter, and detection methods and apparatus

Collision cell

A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.

Gas inlet for a process mass spectrometer

Probe adaptor assembly

Analyser cap

Inert non-adsorbing crimpable capillaries and devices for adjusting gas flow in isotope ratio analysis

Probe adaptor assembly

Method and apparatus for transfer of ions from high pressure to low pressure tolow pressure region

Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry ("REIMS") device

An apparatus comprises: a user interface [1500, fig. 15A]; a robotic probe 1580 which generates an aerosol, smoke or vapour (e.g. for rapid evaporative ionisation mass spectrometry (REIMS); and a mass or ion mobility spectrometer for analysing the aerosol, smoke or vapour. Also disclosed in a laparoscopic tool comprising: an elongate portion; and a first device at the distal end of the elongate portion to generate an aerosol, smoke or vapour from tissue. Further disclosed is an apparatus comprising: a first device which emits a stream of electrically charged droplets at a target (i.e. a desorption electrospray ionisation (DESI) device); a transfer capillary to transfer generated ions from the target to an analyser; and a heating device which heats the first device, the stream of droplets, the target or the transfer capillary.

Chemically guided ambient ionisation mass spectrometry

Collision surface for improved ionisation

A mass and/or ion mobility spectrometer comprises a device arranged to generate aerosol, smoke or vapour from a target to be analysed, and a device arranged to direct the aerosol, smoke or vapour onto a collision assembly. The collision assembly may be a hollow collision assembly having an inner cross-sectional area that reduces from an inlet to an outlet of the hollow collision assembly. Aerosol, smoke or vapour may be received at the inlet to impact upon an inner surface of the hollow collision assembly to generate analyte ions that emerge from the hollow collision assembly via the outlet. Alternatively, the collision assembly may be a mesh. The collision assembly may be located within a vacuum chamber and may be heated. The aerosol, smoke or vapour may be intermixed with a matrix. Droplets of the diluted or dissolved aerosol, smoke or vapour may be accelerated onto the collision assembly by a pressure difference across an atmospheric interface.

GAS INLET TO THE PRODUCTION OF AN ARRANGED ONE AND COOLING GAS JET

Einrichtung zur Analyse eines Probegases umfassend eine Ionenquelle

A device for analyzing a sample gas comprises an ion source (1) for generating primary ions, a reaction chamber (4) to which the primary ions produced in the ion source (1) and the sample gas to be analyzed can be supplied in order to form product ions by chemical ionization of components in the sample gas, and an analyzer/detector unit (18) for determining different types of ions. A reaction space (15) in the reaction chamber (4), within which the primary ions supplied to the reaction chamber (4) and the product ions produced are guided and which extends between a first end (16) facing the ion source (1) and a second end (17) facing the analyzer/detector unit (18), is surrounded by at least two electrodes (9, 10, 11) which are in the form of helices which revolve around a common axis (27) with identical pitches (g) and are offset with respect to one another in the direction of the axis (27). An AC voltage is applied to each of the electrodes (9, 10, 11).

DEVICE AND PROCEDURE FOR THE PROOF OF TRACES OF ORGANIC COMPONENTS

ION MOBILITY SPECTROMETRY

VALVE AND ITS USE

System and method for chemical analysis using laser ablation

SAMPLE INTRODUCTION DEVICE AND PROCESS FOR MASS SPECTROMETER

Procédé et dispositif d introduction d'échantillons pour spectromètre de masse Le dispositif permet d'introduire des microéchantillons dans la source d'ionisation du spectromètre. Il comprend un réacteur (10) muni de moyens d'introduction du micro-échantillon, de moyens de chauffage du micro-échantillon, de moyens de liaison avec une source de vide et de moyens (38, 40) d'amenée d'un débit réglable de réactif de transformation du micro-échantillon en composés gazeux ; un passage étranglé et calibré (12) d'écoulement des gaz à partir du réacteur : et un tube de sublimation (40) relié, d'une part, au passage, d'autre part, à la source d'ions du spectromètre par l'intermédiaire d'une vanne (16), muni de moyens permettant de le porter à une température cryogénique réglable.

SAMPLING SYSTEM FOR MASS SPECTROMETER

An apparatus for introducing a gaseous sample into a mass spectrometer is disclosed which includes a hollow antechamber or cavity disposed between the sample stream and the high vacuum enclosure. Orifice openings are provided in the antechamber which allow the antechamber to communicate both with the high vacuum enclosure and the sample stream. An electrically operated pulsed valve is used to admit a series of small volumes of sample by pulses of controlled duration and frequency such that the sample flow from the antechamber into the high vacuum enclosure can be made to resemble one of essentially constant flow. ?

RESPIRATORY GAS MOISTURE SEPARATOR SYSTEM FOR MASS SPECTROMETER MONITORING SYSTEMS

RESPIRATORY GAS MOISTURE SEPARATOR SYSTEM FOR MASS SPECTROMETER MONITORING SYSTEMS Wet or saturated respiratory gas samples being monitored from one or more hospital patients are sufficiently dried for analysis by a medical mass spectrometer by a novel momentum separator in which the major part of the wet sample flows directly to an exhaust pump while a small sample for analysis is taken from the reverse angle tee connection in the momentum separator. This small sample containing water vapor, but without the heavier moisture droplets,is then heated to about 100.degree.C to maintain the water in the vapor state prior to entering the spectrometer inlet leak.

MULTIPLE STAGE CRYOGENIC PUMP AND METHOD OF PUMPING

SYSTEM FOR INTRODUCING PARTICLE-CONTAINING SAMPLES TO AN ANALYTICAL INSTRUMENT AND METHODS OF USE

Systems and methods for use in introducing samples to an analytical instrument. The systems and methods are adaptable to process either a liquid sample or a gaseous sample, including samples containing particle contaminants, for subsequent analysis using an analytical instrument, such as e.g., a mass spectrometer and/or an inductively coupled plasma mass spectrometer.

ION SOURCE FOR ION MOBILITY SPECTROMETER

An ion mobility spectrometer for analyzing a vapor sample including a multi-ring ion source for receiving a vapor sample, wherein the multi-ring ion source includes a series of rings, wherein each ring of the multi-ring ion source includes an ionizing layer on an inner surface thereof, for charging at least a portion of the vapor sample and creating an ionized vapor sample.

IN VIVO ENDOSCOPIC TISSUE IDENTIFICATION TOOL

An apparatus is disclosed including a tool comprising a first device (21) for generating aerosol (5) from a target (35), the first device (21) being deployed through an opening (37) in a tubing (22) of the tool,wherein the tubing (22) is provided with aspiration ports or fenestrations (30) such that the generated aerosol (5) is aspirated into the tubing (22) via the aspiration ports or fenestrations (30). The aspirated aerosol (5) is then transferred to a mass spectrometer for subsequent mass analysis.

Dual Source Mass Spectrometry System

In or for a dual source mass spectrometer system ( 10 ) operable in a first mode with an LC source [LC/MS] ( 12 ) and in a second mode with a GC source [GC/MS] ( 18 ). The GC source input into an ion source chamber ( 22 ) for delivering the ionized output from the GC source to the mass spectrometer, a GC source unit ( 18 ) comprising a GC interface probe ( 30 ). The GC source unit is retractably mounted to take the GC interface probe from a retracted position in which it is disengaged from the mass spectrometer of the system, (whereby the system is operable in said first LC/MS mode) into a deployed position in which the GC interface probe is operatively connected to the ion source chamber of the mass spectrometer (whereby the system is operable in said second GC/MS mode). The GC interface probe has docking means ( 42, 46, 48 ) for releasable engagement with complementary docking means provided by a housing of the ion source chamber to allow operation with a GC ion source chamber in the second mode.

MULTI-DOPANT PERMEATION TUBE

Aspects and embodiments of the present invention are directed to spectrometry systems and for apparatus and methods for delivering dopants to same. In one example, there is provided a dopant delivery device configured to supply dopants to a spectrometry system comprising a tube including a first chamber and a second chamber, a first dopant source included in the first chamber, and a second dopant source included in the second chamber. 1. A dopant delivery device configured to supply dopants to a spectrometry system comprising:a tube including a first chamber and a second chamber;a first dopant source included in the first chamber; anda second dopant source included in the second chamber.2. The dopant delivery device of claim 1 , wherein the first chamber is defined by to a wall of the tube claim 1 , a first plug inserted into a portion of the tube proximate a first end of the tube claim 1 , and by a second plug inserted into the tube at a position remote from the first end of the tube.3. The dopant delivery device of claim 2 , wherein the second chamber is defined by the wall of the tube claim 2 , a third plug inserted into a portion of the tube proximate a second end of the tube claim 2 , and by the second plug.4. The dopant delivery device of claim 3 , wherein a bore is defined in one of the first plug and the third plug.5. The dopant delivery device of claim 1 , wherein the first dopant source comprises dichloromethane liquid.6. The dopant delivery device of claim 5 , wherein the wall of the tube defining the first chamber is permeable to dichloromethane vapor.7. The dopant delivery device of claim 1 , wherein the second dopant source comprises an ammonia solid.8. The dopant delivery device of claim 7 , configured to emit both dichloromethane vapor and ammonia vapor.9. The dopant delivery device of claim 6 , configured to provide a visual indication of an expiration of the supply of one of the first dopant source and the second dopant source.10. The dopant ...

CURTAIN GAS FILTER FOR HIGH-FLUX ION SOURCES

A curtain-gas filter for a mass- or mobility-spectrometer that bars gases or vapors of a high-flux atmospheric pressure ion source, as we ions of high mobility and charged droplets, from entering an evacuated mass spectrometer or a mobility spectrometer that is at a lower pressure than the main filter volume of the curtain-gas filter. A portion of the ion-source buffer gas in the ion-source plume is sucked through an ion-source buffer gas inlet into the main filter volume of the curtain-gas filter, from where this ion-source gas is exhausted after a properly shaped electric field has pushed a large portion of the embedded ions into an externally provided stream of a clean buffer gas, which is sucked through a passage into a mass- or mobility-spectrometer that is at a lower pressure. 1. A spectrometry system , comprising:an ion source that produces an ion-source plume;an ion-source buffer-gas inlet configured to receive ion-source buffer gas from said ion-source plume;a clean buffer-gas inlet configured to receive a clean buffer gas from an external source; anda curtain-gas filter including,at least one first low-turbulence gas guide that transfers said ion-source buffer gas from said ion-source buffer gas inlet to a main filter volume having a gas pressure lower than a gas pressure of said ion-source plume,at least one second low-turbulence gas guide that transfers said clean buffer gas from said clean buffer-gas inlet to said main filter volume,a passage positioned between an ion extraction volume within the main filter volume and at least one spectrometer having a gas pressure lower than the gas pressure in the main filter volume of said curtain-gas filter, andat least two electrodes placed at different potentials to generate an electric field so as to push ions having a range of mobilities from said ion-source buffer gas in said main filter volume into said clean buffer gas in said main filter volume, to generate an ion containing clean buffer gas in an ion ...

ION SOURCE FOR MASS SPECTROMETRY

Systems and methods for delivering a sample to a mass spectrometer are provided. In one aspect, the system can include a sample source for generating a sample plume entrained in a primary gas stream in a first flow direction at a first flow rate, and a gas source for generating a secondary gas stream along a second flow direction different from the first orifice plate flow direction and at a second flow rate greater than the first flow rate. The sample source and the gas source can be positioned relative to one another such that the primary gas stream intersects the secondary gas stream so as to generate a resultant gas stream propagating along a trajectory different from said first and second direction to bring the sample to proximity of a sampling orifice of the mass spectrometer. 1. A system for directing a sample to a mass spectrometer , comprising:a sample source for generating a sample entrained in a primary gas stream in a first flow direction at a first flow rate,a gas source for generating a secondary gas stream along a second flow direction different from said first flow direction and at a second flow rate greater than said first flow rate,wherein said sample source and said gas source are positioned relative to one another such that the primary gas stream intersects the secondary gas stream so as to generate a resultant gas stream propagating along a trajectory different from said first and second directions to bring said sample to proximity of a sampling orifice of the mass spectrometer such that at least a portion of the sample enters the sampling orifice.2. The system of claim 1 , wherein the intersection of said primary and secondary gas streams is configured to cause at least partial mixing of said gas streams and said sample.3. The system of claim 1 , wherein the sampling orifice is positioned on a longitudinal axis of said mass spectrometer.4. The system of claim 3 , wherein an intersection region of the primary and secondary gas streams is offset ...

ION GENERATION USING WETTED POROUS MATERIAL

The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. 147-. (canceled)48. A system for analyzing an analyte from a gas in an ambient environment , the system comprising:a capture module, the module configured to capture an analyte from a gas in an ambient environment and generate ions of the analyte; anda mass analyzer operably coupled to the capture module to receive the generated ions of the analyte.49. The system according to claim 48 , wherein the capture module comprises a porous substrate connected to a high voltage source.50. The system according to claim 49 , wherein the porous substrate is discrete from a flow of solvent.51. The system according to claim 49 , wherein the porous substrate tapers to a distal tip.52. The system according to claim 49 , wherein the capture module further comprises a gas-flow generating device that directs flow of the gas through the porous substrate.53. The system according to claim 49 , further comprising a solvent applied to the porous substrate.54. The system according to claim 53 , wherein the solvent comprises an internal standard.55. The system according to claim 48 , wherein the gas is air.56. The system according to claim 48 , wherein the mass analyzer is for a mass spectrometer or a handheld mass spectrometer.57. The system according to claim 48 , wherein the mass analyzer is selected from the group consisting of: a quadrupole ion trap claim 48 , a rectilinear ion trap claim 48 , a cylindrical ion trap claim 48 , a ion cyclotron resonance trap claim 48 , an orbitrap claim 48 , a time of flight claim 48 , a Fourier Transform ion cyclotron resonance claim 48 , and sectors. The present application is a continuation of U.S. nonprovisional application Ser. No. 13/926,645, filed Jun. 25, 2013, which is a continuation-in-part of U.S. nonprovisional application Ser. No. 13/265,110, filed Jan. 31, 2012, which application is a national phase application and claims the ...

APPARATUS FOR PROVIDING GASEOUS SAMPLE IONS/MOLECULES AND A CORRESPONDING METHOD

An apparatus for providing gaseous sample ions/molecules from liquid droplets containing sample ions/molecules. The apparatus has a chamber having one or more walls which define an interior of the chamber, the chamber being configured to receive liquid droplets containing sample ions/molecules. The apparatus also has a gas flow producing means configured to produce a flow of gas within the chamber for promoting evaporation of liquid droplets in the chamber to provide gaseous sample ions/molecules. The apparatus is configured such that the flow of gas produced within the chamber inhibits liquid droplets in the chamber from coming into contact with the one or more walls of the chamber. 1. An apparatus for providing gaseous sample ions/molecules from liquid droplets containing sample ions/molecules , the apparatus having:a chamber having one or more walls which define an interior of the chamber, the chamber being configured to receive liquid droplets containing sample ions/molecules;a gas flow producing means configured to produce a flow of gas within the chamber for promoting evaporation of liquid droplets in the chamber to provide gaseous sample ions/molecules;wherein the apparatus is configured such that the flow of gas produced within the chamber inhibits liquid droplets in the chamber from coming into contact with the one or more walls of the chamber.2. An apparatus according to claim 1 , wherein the apparatus is configured such that the flow of gas produced within the chamber has a vortex or swirling structure in at least a region of space within the chamber.3. An apparatus according to wherein the flow of gas within the chamber has an inner region and an outer region in which the flow of gas has an axial velocity in a forward direction claim 1 , as well as an intermediate region claim 1 , between the inner region and outer region claim 1 , in which the flow of gas has an axial velocity in a reverse direction that is opposite to the forward direction.4. An ...

Ion Mobility Spectrometer Which Controls Carrier Gas Flow to Improve Detection

IMS apparatus has an inlet with a preconcentrator opening into a reaction region where analyte molecules are ionized and passed via a shutter to a drift region for collection and analysis. A pump and filter arrangement supplies a flushing flow of clean gas to the housing in opposition to ion flow. A pressure pulser connects with the housing and is momentarily switched to cause a short drop in pressure, in the housing to draw in a bolus of analyte sample from the preconcentrator. Just prior to admitting a bolus of sample, the pump is turned off so that the flushing flow drops substantially to zero, thereby prolonging the time the analyte molecules spend in the reaction region.

Mass spectrometer interface

A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

SENSOR APPARATUS AND METHOD FOR USE WITH GAS IONIZATION SYSTEMS

An ion mobility gas detector apparatus including a detector core, an inlet gas path, an exhaust gas path, a source of diluent gas, and at least one or more sensors for measuring temperature, pressure and humidity of gas streams. Further included is a mixing mechanism adapted to mix at least first and second gas streams in response to one or more sensor measurements. A controller is provided for applying drive signals to the detector core. 173-. (canceled)74. A method for mixing gas streams in an ion mobility sensor , comprising:providing a first inlet gas stream to the ion mobility sensor;providing a second diluent gas stream to the ion mobility sensor;measuring at least one of temperature, pressure and humidity of each first and second gas stream; andmixing at least the first and second gas streams in response to measurement of at least the first and second gas streams.75. The method as recited in claim 74 , wherein the ion mobility sensor further includes:a detector core;an inlet gas path; andan outlet gas path.76. The method as recited in claim 75 , further including applying drive signals to the detector core.77. The method as recited in claim 76 , wherein a controller applies the drive signals to the detector core.78. The method as recited in claim 74 , wherein at least one or more sensors are used to measure at least one of temperature claim 74 , pressure and humidity of each first and second gas stream.79. The method as recited in claim 74 , wherein a mixing mechanism mixes at least the first and second gas streams in response to measurement of at least the first and second gas streams.80. The method as recited in wherein the at least one or more sensors includes a humidity sensor positioned in a gas flow path connected in parallel with the detector core whereby at least a portion of inlet gas passes over the humidity sensor.81. The method as recited in wherein the ion mobility gas detector is a Field Asymmetric Ion Mobility Spectrometry (FAIMS) detector.82. ...

SAMPLE ANALYSIS METHOD AND SAMPLE INTRODUCTION DEVICE

A desolvation unit performs desolvation by heating after a sample solution is turned to sample mist by a nebulizer. A sample gas that contains the desolvated sample mist and a carrier gas is introduced through a sample introduction tube to a plasma torch. An addition unit for adding, to the sample introduction tube, a water-containing gas is provided. The addition unit includes a container that contains ultrapure water, a gas tube for introducing the carrier gas into the ultrapure water to cause bubbling, and a gas tube for adding the water-containing gas, to the sample introduction tube. The plasma torch generates an inductively coupled plasma under the condition that supplied power is set to a range of 550 W to 700 W. Generation of interfering molecule ions due to an element having a high ionization potential is inhibited when an element in a sample ionized by the plasma is analyzed. 1. A sample analysis method for introducing , to plasma , a sample gas that contains sample mist having been desolvated by heating , and a carrier gas that transports the sample mist , and analyzing an element in a sample ionized by the plasma , the sample analysis method comprisingadding a water-containing gas as a carrier gas that contains water, to a path for introducing the sample gas to the plasma.2. The sample analysis method according to claim 1 , wherein the water-containing gas is generated by bubbling of the carrier gas in ultrapure water.3. The sample analysis method according to claim 1 , wherein the water-containing gas is generated by immersing claim 1 , in ultrapure water claim 1 , a carrier gas line formed by a hollow fiber filter.4. The sample analysis method according to claim 1 , wherein the plasma is an inductively coupled plasma generated by setting supplied power to a range of 550 W to 700 W.5. A sample introduction device applied to a method for introducing claim 1 , to plasma claim 1 , a sample gas that contains sample mist having been desolvated by heating ...

ION INLET ASSEMBLY

An ion inlet assembly for connecting to a mass spectrometer housing is disclosed comprising a sampling limiting body () having a sampling orifice (). The sampling limiting body () comprises a nickel disk wherein the disk and sampling orifice () are made or formed by an electroforming process. 1. An ion inlet assembly for connecting to a mass spectrometer housing comprising:a gas cone assembly having a gas cone orifice; anda sampling limiting body having a sampling orifice;wherein said sampling limiting body is removably attached beneath the gas cone assembly to the mass spectrometer housing.2. An ion inlet assembly as claimed in wherein said sampling limiting body comprises a disk.3. An ion inlet assembly as claimed in claim 1 , wherein said gas cone assembly is connectable to a gas supply such that gas is arranged to flow claim 1 , in use claim 1 , towards said gas cone orifice.4. An ion inlet assembly as claimed in claim 2 , wherein said disk is flat.5. (canceled)6. An ion inlet assembly as claimed in claim 2 , wherein said disk is substantially round or circular.7. (canceled)8. (canceled)9. (canceled)10. An ion inlet assembly as claimed in claim 1 , wherein said sampling limiting body is arranged to be supplied with a voltage in use.11. An ion inlet assembly as claimed in claim 1 , wherein said sampling orifice is substantially round or circular.12. An ion inlet assembly as claimed in claim 1 , wherein said sampling limiting body comprises a plurality of sampling orifices.13. An ion inlet assembly as claimed in claim 1 , further comprising a vacuum holding member having an orifice to allow the flow of ions into a mass spectrometer.14. An ion inlet assembly for connecting to a mass spectrometer housing comprising:a gas cone assembly having a gas cone orifice;a sampling limiting body having an orifice, wherein said sampling limiting body is removably attached beneath the gas cone assembly to the mass spectrometer housing; anda vacuum holding member having an ...

IONIZATION WITH FEMTOSECOND LASERS AT ELEVATED PRESSURE

The present disclosure generally provides ionization methods and devices for use in mass spectrometry. In some embodiments, the ionization methods and devices employ short laser pulses (e.g., pulses having pulsewidths in a range of about 2 fs to about 1 ps) at a high intensity (e.g., an intensity in a range of about 1 TW/cmto about 1000 TW/cm) to ionize an analyte an ambient pressure greater than about 10Torr (e.g., an ambient pressure in a range of about 1 atmosphere to about 100 atmospheres). 1. In a mass spectrometer , a method for ionizing a sample , comprising:{'sup': −5', '5', '2', '2, 'irradiating a sample at an ambient pressure in a range of about 10Torr to about 10Torr with one or more radiation pulses having a pulsewidth in a range of about 2 fs to about 1 ps at a pulse power density in a range of about 1 TW/cmto about 1000 TW/cmto cause ionization of at least a portion of the sample.'}2. The method of claim 1 , wherein said radiation pulses have a pulsewidth in a range of about 30 fs to about 500 fs.3. The method of claim 1 , wherein said radiation pulses have a pulsewidth in a range of about 50 fs to about 100 fs.4. The method of claim 1 , further comprising introducing the sample into an ionization chamber and focusing said radiation pulses onto a focal volume in said chamber to cause said ionization of the sample.5. The method of claim 1 , wherein said radiation pulses cause non-resonant ionization of one or more constituents of said sample.6. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 200 nm to about 100 microns.7. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 600 nm to about 10 microns.8. The method of claim 1 , wherein said radiation pulses have a central wavelength in a range of about 800 nm to about 3 microns.9. The method of claim 1 , wherein said radiation pulses are applied to the sample at a repetition rate in a range of about 1 Hz to ...

MASS SPECTROMETER

The mass spectrometer () provides an ionization chamber () therein with: a probe () having a sample to be measured flow path () for spraying a sample to be measured; and a standard sample flow path () for spraying a standard sample used for the calibration of the mass-to-charge ratio of the mass spectrum into the ionization chamber. The standard sample is intermittently introduced into the ionization chamber via a pulse valve (). Thus, mixing of the sample to be measured and the standard sample can be prevented, while the timing according to which the standard sample is introduced can be appropriately controlled. It also becomes possible to acquire an accurate mass spectrum for each sample to be measured even in the case where a number of types of samples to be measured are introduced into the ionization chamber one after another over a short period of time. 1. A mass spectrometer , comprising an ionization chamber where a sample is ionized , and a mass spectrometry unit into which ions are introduced from the ionization chamber , whereinsaid ionization chamber has a housing that provides a space inside the housing,a probe having a sample to be measured flow path in order to spray a sample to be measured into the inside of said ionization chamber is attached to said housing, and an ion introducing tube is created in said housing so that the inside of said ionization chamber and the inside of the mass spectrometry unit communicate,a mass spectrum value that is gained by measuring a sample to be measured is calibrated using a mass spectrum value that is gained by measuring a standard sample, andthe mass spectrometer is characterized by further comprising a standard sample flow path that sprays a standard sample into the inside of said ionization chamber, and a pulse valve that is arranged in the standard sample flow path so as to introduce a standard sample intermittently.2. The mass spectrometer according to claim 1 , characterized in that said standard sample flow ...

SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS

The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. 128-. (canceled)29. A system for analyzing a sample , the system comprising:an ionizing source for converting molecules of a sample into sample ions, the ionizing source comprising a gas inlet port and an electrode positioned within the source to interact with a gas introduced through the gas inlet port and to generate a discharge that interacts with the sample to produce the sample ions;an ion analysis device; andan ion transfer member operably coupled to a gas flow generating device, wherein the gas flow generating device produces a laminar gas flow without regions of recirculation that transfers the sample ions through the ion transfer member to an inlet of the ion analysis device.30. The system according to claim 29 , further comprising a gas source operably coupled to the gas inlet port.31. The system according to claim 30 , wherein the gas is helium.32. The system according to claim 29 , wherein the gas flow generating device is a pump.33. The system according to claim 29 , wherein the gas flow generating device is a gas jet of the ionizing source.34. The system according to claim 29 , wherein the ion transfer member is a tube.35. The system according to claim 34 , wherein the tube is composed of a rigid material.36. The system according to claim 35 , wherein the rigid material is metal or glass.37. The system according to claim 34 , wherein the tube is composed of a flexible material.38. The ...

PROTON TRANSFER REACTION MASS SPECTROMETER

A mass spectrometer includes an ion source configured to generate reagent ions; a drift tube configured to cause sample molecules to react with the reagent ions to generate sample ions, the drift tube comprising two sets of electrodes which are identical in structure and symmetrically distributed in a direction perpendicular to a direction of ion drift, each set of electrodes comprising a plurality of curved cell electrodes which are distributed in a same plane and arranged in the direction of ion drift so that the sample ions are generated and drifted within a region between the two sets of electrodes and focused in the direction perpendicular to the direction of ion drift; a power supply device configured to apply, to each of the cell electrodes, a DC voltage changing in the direction of ion drift; and, a mass analyzer configured to perform mass analysis for the sample ions. 1. A mass spectrometer , comprising:an ion source configured to generate reagent ions;a drift tube configured to cause sample molecules to react with the reagent ions to generate sample ions, said drift tube comprising two sets of electrodes which are identical in structure and symmetrically distributed in a direction perpendicular to a direction of ion drift, each set of electrodes comprising a plurality of curved cell electrodes which are distributed in a same plane and arranged in the direction of ion drift so that the sample ions are generated and drifted within a region between said two sets of electrodes and focused in the direction perpendicular to the direction of ion drift;a power supply device configured to apply, to each of the cell electrodes, a DC voltage changing in the direction of ion drift, a DC electric field formed by said DC voltage being used for ion drift; anda mass analyzer configured to perform mass analysis for the sample ions.2. The mass spectrometer according to claim 1 , wherein the cell electrodes are ring or arc electrodes claim 1 , and each set of electrodes ...

ICP MASS SPECTROMETER

Provided is an ICP mass spectrometer which is able to effectively discharge residual water by limiting the consumption of Ar gas and a fluctuation in supply pressure of an Ar gas source at the time of an Ar gas purge for a coolant system. The ICP mass spectrometer is provided with: a device body part ; a coolant system that supplies a coolant from a water source to to-be-cooled structure parts including a high-freqency power supply , a high-frequency coil , and a sample introduction part , which need to be cooled; and an Ar gas supply system . Intermediate valves V, V are disposed on the downstream side of a main valve V, a purge gas channel having a purge valve V, and a meeting point G of the purge gas channel . The to-be-cooled structure parts are connected to a cooling-use pipe on the downstream side of the intermediate valves V, V. A valve control part in configured to perform intermittent purge control of repeating accumulation and discharge of the Ar gas on the upstream side of the intermediate valves V, V by intermediately opening and closing the intermediate valves V, V where the Ar gas is being sent. 1. An ICP mass analysis device characterized in that it comprises:a device main body unit which supplies Ar gas for plasma generation and sample gas, via a gas flow rate control unit which controls gas flow rate, to a reaction tube of a plasma torch, ionizes the sample gas by applying a high frequency voltage from a high frequency power supply to a high frequency coil of said plasma torch, and draws in generated sample ions through a sample introduction unit to a mass analyzer to perform mass analysis;a cooling water system in which water cooling piping is connected as a flow passage to cooled structures which require cooling, including said high frequency power supply, said high frequency coil and said sample introduction unit, and which supplies cooling water from a water source to said cooled structures; andan Ar gas supply system in which gas piping is ...

IRMS Sample Introduction System and Method

A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products. 1. A spectrometer , comprising:a liquid sample preparation arrangement for providing a liquid sample, a desolvation region, arranged to receive or generate sample ions from a solvent matrix, and to remove at least a proportion of the solvent matrix from the sample ions;', 'a separation chamber positioned downstream of the desolvation region and having a separation chamber inlet in fluid communication with the desolvation region, for receiving the desolvated sample ions along with solvent vapours comprising non-ionised solvent and solvent ions, the separation chamber having electrodes for generating an electric field within the separation chamber, which defines a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet, but which causes unwanted solvent ions and unwanted non-ionised solvent vapours to be directed away from the separation chamber outlet; and', 'a reaction chamber having an inlet in fluid communication with the separation chamber ...

IRMS Sample Introduction System and Method

A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. The separation chamber has electrodes for generating an electric field within the separation chamber, defining a first flow path for sample ions between the separation chamber inlet and a separation chamber outlet. Unwanted solvent ions and non-ionised solvent vapours are directed away from the separation chamber outlet. The sample introduction system has a reaction chamber with an inlet communicating with the separation chamber outlet, for receiving the sample ions from the separation chamber and for decomposing the received ions into smaller products. 1. A method of introducing a sample into an Isotope Ratio Spectrometer , comprising steps of(a) generating sample ions in a solvent matrix;(b) removing at least a proportion of the solvent matrix from the sample ions in a desolvation chamber, so as to produce a flow of sample ions along with non-ionised solvent and solvent ions;(c) in a separation chamber, applying an AC and/or a DC electric field to the flow of ions along with solvent vapours, so as to direct wanted sample ions, having a first mass to charge ratio or range of mass to charge ratios, along a first flow path towards an outlet of the separation chamber, whilst unwanted solvent ions, other ions, and non-ionized solvent are directed away from the said separation chamber outlet, the unwanted solvent ions and other ions having a second mass to charge ratio or range of mass to charge ratios, different to the said first mass to charge ratio or range of ratios; and(d) decomposing the sample ions to molecular products once they ...

NANOPARTICULATE ASSISTED NANOSCALE MOLECULAR IMAGING BY MASS SPECTROMETRY

Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source. 1. An instrument for the preparation of a sample , the instrument comprising:a first differentially-pumped vacuum region comprising a nanoparticulate beam source configured to create and accelerate a nanoparticulate ion beam;a second differentially-pumped vacuum region coupled to the first differentially-pumped vacuum region for accelerating and focusing the nanoparticulate ion beam;a third differentially-pumped vacuum region coupled to the second differentially-pumped vacuum region, wherein the third differentially-pumped vacuum region comprises a sample stage for positioning the sample for implantation in the sample with nanoparticles from the nanoparticulate ion beam; andat least one deposition source coupled to at least one of the first differentially-pumped vacuum region, second differentially-pumped vacuum region, and third differentially-pumped vacuum region.2. The instrument of claim 1 , wherein the at least one deposition source is configured to modify the nanoparticles of the nanoparticulate ion beam.3. The instrument of claim 1 , wherein the at least one deposition source is configured to co-deposit material from the at least one deposition source with the nanoparticles from the nanoparticulate ion beam.4. The instrument of claim 3 , wherein the at least one deposition source is configured to simultaneously co-deposit material with the implantation of the sample with the nanoparticles.5. The instrument of claim 2 , wherein the at least one deposition source is configured to add material to a surface of the nanoparticles of the nanoparticulate ion beam.6. The instrument of claim 2 , wherein the at least one deposition source is coupled to the first ...

DETECTION APPARATUS AND DETECTION METHOD

A detection apparatus and a detection method are disclosed. In one aspect, the detection apparatus includes a sampling device for collecting samples to be checked. It further includes a sample pre-processing device configured to pre-process the sample from the sampling device. It further includes a sample analyzing device for separating samples from the pre-processing device and for analyzing the separated samples. The detection apparatus is miniaturized and highly precise, and is capable of quickly and accurately detecting gaseous phase or particulate substances, and it has applications for safety inspections at airports, ports, and subway stations. 1. A detection apparatus comprising:a sampling device for collecting a sample to be detected;a sample pre-processing device configured to pre-process the sample from the sampling device; anda sample analyzing device for separating the pre-processed sample and analyzing the separated sample.2. The detection apparatus of claim 1 , wherein the sampling device comprises a chamber body comprising:a sample inlet that is at a first end of the chamber body and is for suction of the sample;a sample outlet that is adjacent to a second end, opposite to first end, of the chamber body and is for discharge of the sample;an air inflation opening configured to induct a flow of air into the chamber body; andan air exhaust opening configured to discharge the air and to, together with the air inflation opening in the chamber body, form a tornado type air flow moving spirally from the first end to the second end of the chamber body,wherein a section of the chamber body has an inner wall with a truncated conical shape, the truncated conical shaped inner wall having a smaller-diameter round end being adjacent to the sample inlet and a larger-diameter round end being adjacent to the sample outlet of the chamber body, andwherein the air inflation opening is configured such that an axially air induction direction of the air inflation opening is ...

MASS SPECTROMETER SYSTEM AND METHOD

An object of the invention is to provide a mass spectrometer system capable of obtaining a mass spectrum with high resolution as the mass number of an ion becomes higher. In the mass spectrometer system of the invention, a control unit controls a mass spectrometry unit so that a direct current voltage U, an amplitude V of a radio-frequency voltage, and a frequency F of the radio-frequency voltage, which are applied to a quadrupole electrode , are increased as a mass-to-charge ratio m/z of an ion of a target for mass spectrometry becomes larger. By controlling in this manner, the ion frequency when the ion passes through the inside of the mass spectrometry unit is increased as the mass number of an ion becomes higher, and therefore, it is possible to obtain the mass spectrum with higher resolution. 1. A mass spectrometer system , comprising:a mass spectrometry unit that performs mass selection and separation of an ion species having a specific mass-to-charge ratio m/z by applying a direct current voltage U and a radio-frequency voltage VcosΩt to a multipole electrode to generate a multipole electric field, injecting an ionized sample thereinto, and adjusting and controlling the voltage applied to the multipole electrode so that the ion species having a specific mass-to-charge ratio m/z passes through the multipole electrode;an ion detecting unit that detects the ion species;a data processing unit that processes an output of the ion detecting unit; anda control unit that controls the mass spectrometry unit,wherein the control unit controls the mass spectrometry unit such that an ion frequency of the ion species is increased in proportion to the value of the mass-to-charge ratio m/z of the ion species allowed to pass through the multipole electrode.2. The mass spectrometer system according to claim 1 ,wherein the control unit controls values of the direct current voltage U, an amplitude V of a radio-frequency voltage, and an angular frequency Ω of the radio-frequency ...

CONTROL OF GAS FLOW

The invention relates to a gas inlet system for providing gas into an analytical apparatus, comprising at least a first and a second flow restriction that are arranged on a gas inlet line, a gas flow control line connected to the gas inlet line, a gas flow controller on the gas control line, and valves for controlling gas flow in the gas inlet line and the gas control line. Also provided is a method of controlling gas flow into an analytical apparatus. 1. A gas inlet system for providing gas into an analytical apparatus , the system comprising(a) at least one gas inlet line fluidly connected to the apparatus, for introducing gas into the apparatus;(b) at least one valve arranged on the at least one gas inlet line, for controlling flow of gas in the at least one gas inlet line;(c) at least one gas flow control line fluidly connected to the at least one gas inlet line through at least one gas inlet junction;(d) at least one first flow restriction and at least one second flow restriction arranged on the at least one gas inlet line, upstream from and downstream from the at least one gas inlet junction, respectively;(e) at least one back pressure regulator arranged on the at least one gas flow control line to control pressure at the at least one gas inlet junction;(f) at least one valve for controlling flow of gas in the at least one gas flow control line; and(g) at least one vacuum pump or exhaust that is fluidly connected to the at least one gas control line, downstream from the back pressure regulator.2. The gas inlet system of claim 1 , wherein the first flow restriction and/or the second flow restriction claim 1 , when provided as a plurality of restrictions claim 1 , are arranged in a parallel arrangement on the gas inlet line claim 1 , and wherein the gas inlet line optionally further comprises at least one valve for selectively directing flow through the plurality of restrictions.3. The gas inlet system of claim 1 , wherein the second flow restriction is provided ...

Device for mass spectrometry

A device for mass spectrometry in continuous operation can be equipped with a focused electron beam source or laser radiation source. It can further include a vacuum chamber, a stage for placing the specimen, and an ion beam column with a plasma source for producing a primary ion beam and a secondary ion mass spectrometer for secondary ion analysis. The ion beam column is connected to an inert gas source and to a reactive gas source and is modified for simultaneous introduction of at least two gases from the inert gas source and reactive gas source. The secondary ion mass spectrometer is of an orthogonal Time-of-Flight type to ensure the function with the ion beam column in continuous operation. 1. Device for mass spectrometry including a vacuum chamber , stage for placing a specimen , ion beam column with a plasma source for producing primary ion beam and a secondary ion mass spectrometer for analyzing secondary ions , wherein the ion beam column is connected to the inert gas source and the reactive gas source , wherein at least two gasses are continuously introduced from the inert gas source and the reactive gas source , and that the secondary ion mass spectrometer is of an orthogonal Time-Of-Flight type to ensure the function with the ion beam column in continuous operation.2. Device for mass spectrometry according to claim 1 , wherein the plasma source is of an Electron Cyclotrone Resonance type.3. Device for mass spectrometry according to claim 1 , wherein the ion beam column produces a focused ion beam.4. Device for mass spectrometry according to claim 1 , wherein the reactive gas source is an oxygen source.5. Device for mass spectrometry according to claim 1 , wherein the inert gas source is xenon source.6. Device for mass spectrometry according to claim 1 , wherein the inert gas source is argon source.7. Device for mass spectrometry according to claim 1 , wherein the inert gas source is helium source.8. Device for mass spectrometry according to claim 1 , ...

APPARATUS AND METHOD FOR ANALYZING EVOLVED GAS

Disclosed is an apparatus and method for analyzing an evolved gas, wherein the precision of detection of a gas component is improved without enlarging the apparatus. The apparatus includes a gas component evolving unit, a detection member for detecting the gas component, and a mixed gas channel for allowing a mixed gas containing the gas component and carrier gas to flow therethrough, and further includes a branch channel branched from the mixed gas channel, an inert gas channel for allowing an inert gas to flow therethrough, a first flow rate regulator for adjusting the flow rate of the carrier gas, a second flow rate regulator for adjusting the flow rate of the inert gas, and a flow rate control unit for controlling the second flow rate regulator such that the flow rate of the mixed gas guided to the detection member is a predetermined value. 1. An apparatus for analyzing an evolved gas , comprising:a gas component evolving unit configured to evolve a gas component contained in a sample,a detection member configured to detect the gas component evolved from the gas component evolving unit, anda mixed gas channel configured to connect the gas component evolving unit and the detection member to each other and to allow a mixed gas comprising the gas component and a carrier gas for guiding the gas component to the detection member to flow therethrough,and further comprising:a branch channel branched from the mixed gas channel and open to an outside,an inert gas channel joined to the mixed gas channel at a junction downstream of the branch channel such that an inert gas is allowed to flow therethrough,{'b': '1', 'a first flow rate regulator configured to adjust a flow rate F of the carrier gas,'}{'b': '4', 'a second flow rate regulator configured to adjust a flow rate F the inert gas flowing through the inert gas channel, and'}a flow rate control unit configured to control the second flow rate regulator such that a flow rate of the mixed gas guided to the detection ...

Method and System for Decoupling a Capillary Column from a Gas Chromatography-Mass Spectrometry (GC-MS) System

A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (CG-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.

MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD

A mass spectrometry device that is provided with an ionization unit and ionizes, by the ionization unit, a sample separated by a separation column, subjects the sample to mass separation and detect ions obtained in the mass separation, includes: a gas introduction unit that introduces a first gas obtained by vaporizing a liquid into the ionization unit using a second gas, wherein: the ionization unit ionizes the sample by reacting ions obtained by ionizing the first gas with the sample. 19-. (canceled)10. A mass spectrometry device that is provided with an ionization unit and ionizes , by the ionization unit , a sample separated by a separation column , subjects the sample to mass separation and detect ions obtained in the mass separation , comprising:a gas introduction unit that introduces a first gas obtained by vaporizing a liquid into the ionization unit using a second gas, wherein:the ionization unit ionizes the sample by reacting ions obtained by ionizing the first gas with the sample.11. The mass spectrometry device according to claim 10 , further comprising:a gas supply unit that pressurizes the liquid by the second gas.12. The mass spectrometry device according to claim 11 , further comprising:a pressure control unit that controls the pressure applied to the liquid.13. The mass spectrometry device according to claim 12 , wherein:the pressure control unit pressurizes the liquid by controlling the pressure of the second gas that is introduced into a sealed container in which the liquid is placed.14. The mass spectrometry device according to claim 10 , wherein:the gas introduction unit introduces the gas containing the first gas into the ionization unit at a pressure of 1 kPa or more and a flow rate of 1 mL/min or less.15. The mass spectrometry device according to claim 11 , wherein:the gas introduction unit introduces the gas containing the first gas into the ionization unit at a pressure of 1 kPa or more and a flow rate of 1 mL/min or less.16. The mass ...

Gaseous Mercury Detection Systems, Calibration Systems, and Related Methods

Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air. For example, the gaseous mercury detection systems collect gas-phase mercury-compounds from ambient air and release the gas-phase mercury-compounds at concentrations capable of being measured by a gas-chromatography mass spectrometer without heating the gas-phase mercury-compounds above a decomposition temperature of at least one gaseous mercury compound that may present in the mercury-containing gas. The calibration systems are configured to determine an accuracy of or calibrate a gaseous mercury detection system. The disclosed calibration systems may be integrated with or distinct from the gaseous mercury detection systems disclosed herein. 1. A gaseous mercury detection system , comprising: cool the mercury collection surface to a temperature of about 5° C. above an ambient water dew point temperature; and', 'collect on the mercury collection surface at least one of gaseous elemental mercury (GEM) or a gaseous mercury compound (GMC) from a mercury-containing gas;, 'a mercury collector, including a mercury collection surface, the mercury collector configured toa heater positioned and configured to heat the mercury collection surface to a first release temperature and release thereby the at least one of GEM or GMC collected, wherein the first release temperature is below a decomposition temperature of the at least one GMC; capture the at least one of GEM or GMC released from the mercury collector at a temperature of about 0° C. or less, and', 'release the at least one of GEM or GMC captured in the sample trap at a second release temperature, the second release temperature being below the decomposition temperature of the at least one GMC; and, 'a sample trap fluidly coupled to the mercury collector, the sample trap configured toa gas ...

Method of evaluating analysis device, method of calibrating analysis device, analysis method, analysis device and non-transitory computer readable medium

A method of evaluating an analysis device that is capable of detecting each of a plurality of compounds included in a sample includes introducing the sample including a first compound into the analysis device for measurement and detecting the first compound and at least one reaction product derived from the first compound, and acquiring information representing whether the analysis device is in a suitable state for an analysis based on an intensity of the detected first compound and an intensity of each of the detected at least one reaction product, and a relative response factor in regard to each of the first compound and the at least one reaction product.

System and Method of Matrix Accelerated Vacuum-Assisted Sorbent Extraction for Improved Sample Preparation Prior to GCMS Analysis

Techniques disclosed herein can improve the extraction of chemicals prior to analysis by GC or GCMS. A liquid or solid sample can be placed in a sample container of a closed system under vacuum that further includes a sample extraction device. The assembly can be placed in a 3-zone heater that can separately control the temperature of the bottom of the sample container, the top of the sample container, and the sample extraction device. Vapor flux from the bottom of the sample container into the headspace of the sample container can deliver compounds of interest to the sample extraction device, whereas matrix compounds can re-condense in the headspace of the sample container to avoid delivery to the sample extraction device. Extraction can continue until substantial transfer of compounds of interest to the sorbent occurs, followed by thermal desorption of the extract into a GCMS for analysis. 1. A closed system for preparing a sample under vacuum , the system comprising:a sample container configured to hold the sample;a sorbent;a first heater configured to apply a first temperature to a first portion of the sample container;a second heater configured to apply a second temperature that is less than the first temperature to a second portion of the sample container;one or more heat sinks, fans, or sub-ambient cooling devices configured to maintain the second temperature; anda third heater configured to apply a third temperature that is greater than the second temperature to the sorbent.2. The system of claim 1 , further comprising:a vacuum sleeve configured to form a vacuum-tight seal between the sample container and a sample extraction device containing the sorbent.3. The system of claim 2 , wherein the sample extraction device includes a port or a seal configured to be coupled to a vacuum source while a vacuum is being pulled in the system.4. The system of claim 1 , wherein the sorbent is disposed in a sample extraction device claim 1 , the sample extraction device ...

Apparatus and Methods for an Atmospheric Sampling Inlet for a Portable Mass Spectrometer

Atmospheric sampling system designed to minimize cross-contamination between successive samples acquired by a portable, or handheld, mass spectrometer. Techniques to reduce the overall sample load on portable mass spectrometers having limited pumping capacity, such as capture pumps. Techniques and methods employing simple manual devices and micro vacuum pumps for purging the inlet system of a mass spectrometer. Reduction of cross-contamination between successive samples, permitting a portable mass spectrometer to correctly associate sample positives with specific sample sites or individuals. 1. A pulsed atmospheric sampling system for a portable mass spectrometer comprising:an inlet port for sample injection;a capillary line for transfer of said sample injection into said portable mass spectrometer;a pulse valve for controlling the time period of said sample injection through said capillary line;a rubber bulb used to manually evacuate the previously injected sample from said capillary line and said pulse valve.2. The sampling system of claim 1 , in which said rubber bulb is used to purge the sample inlet line by compressing said rubber bulb claim 1 , placing said rubber bulb over said inlet port claim 1 , and releasing said rubber bulb claim 1 , effectively purging said sample inlet line.3. The sampling system of claim 1 , in which an additional port with a corresponding cap or valve claim 1 , is connected to said capillary line.4. The sampling system of claim 3 , in which said rubber bulb is placed over said additional port claim 3 , and alternately compressed and released claim 3 , effectively purging said sample inlet line.5. The sampling system of claim 3 , in which said additional port is opened to atmosphere claim 3 , and said rubber bulb is placed over said inlet port and alternately compressed and released claim 3 , effectively purging said sample inlet line.6. A method for reducing sample cross-contamination from a pulsed atmospheric sampling system for a ...

System for Introducing Particle-Containing Samples to an Analytical Instrument and Methods of Use

Systems and methods for use in introducing samples to an analytical instrument. The systems and methods are adaptable to process either a liquid sample or a gaseous sample, including samples containing particle contaminants, for subsequent analysis using an analytical instrument. 1. A system configured to receive a liquid sample or a gaseous sample to be provided to an analytical device , the system comprising:an chamber comprising an outer housing having an inlet end and an outlet end;the inlet end having a gas inlet port configured to receive a gaseous sample from a gaseous sample source and a liquid inlet port configured to receive a liquid sample from a liquid sample source and form a liquid sample aerosol from the liquid sample;the outlet end having an outlet port coupled to a gas exchange device so that the gaseous sample or liquid sample will flow through the outlet port to the gas exchange device;an interior chamber extending between the inlet end and the outlet end, the interior chamber connected to the liquid inlet port to receive the liquid sample; andthe chamber being operable to selectively receive either the gaseous sample or the liquid sample.2. The system of further comprising a nebulizer connected to the liquid inlet port to create the liquid sample aerosol from the liquid sample.3. The system of further comprising a gas flow conduit to convey the gaseous sample from the gaseous sample source to the gas inlet port.4. The system of further comprising a selector valve connected to the gas flow conduit claim 3 , and wherein the gaseous sample source comprises different gaseous samples such that the selector valve selectively switches between the different gaseous samples.5. The system of further comprising a mass flow controller connected to the gas flow conduit to control flow rate of the gaseous sample.6. The system of wherein the gas exchange device has an inlet aperture for receiving the liquid sample aerosol or gaseous sample from the outlet port ...

MASS SPECTROMETER

A mass spectrometer of reduced size and weight is provided which is capable to conduct highly accurate mass spectroscopy. The mass spectrometer includes an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample and a mass spectroscopy section for separating the ionized measurement sample. The ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when the interior pressure rises as it inhales the gas, and the mass spectroscopy section separates the ionized measurement sample when its interior pressure falls after inhale of the gas. The mass spectrometer may further include a restriction device for suppressing a flow rate of the gas the ion source inhales and an open/close device for opening and closing a flow of the gas the ion source inhales. 117-. (canceled)18. A mass spectrometer comprising:an ion source adapted to ionize gas flowing in from outside in order to ionize a measurement sample; and the ion source has its interior reduced in pressure by differential pumping from the mass spectroscopy section and ionizes the gas when its interior pressure rises up to about 100 Pa to about 10,000 Pa as it inhales the gas;', 'the mass spectroscopy section separates the ionized measurement sample when its interior pressure raised concomitantly with inhale of the gas falls to about 0.1 Pa or lower after inhale of said gas., 'a mass spectroscopy section for separating the ionized measurement sample, wherein19. The mass spectrometer according to further comprising:a restriction device for suppressing a flow rate of the gas that the ion source inhales; andan open/close device for opening and closing a flow of the gas that the ion source inhales.20. The mass spectrometer according to claim 19 , wherein the restriction device and the open/close device are arranged on an upstream side of flow of the gas with respect to the ion source.21. The mass spectrometer ...

Physically Guided Rapid Evaporative Ionisation Mass Spectrometry ("REIMS")

A method is disclosed comprising obtaining physical or other non-mass spectrometric data from one or more regions of a target using a probe. The physical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target. An ambient ionisation ion source may then used to generate an aerosol, smoke or vapour from one or more regions of the target.

Spectrometric Analysis

A method of spectrometric analysis comprises obtaining one or more sample spectra for an aerosol, smoke or vapour sample. The one or more sample spectra are subjected to pre-processing and then multivariate and/or library based analysis so as to classify the aerosol, smoke or vapour sample. The results of the analysis are used for various surgical or non-surgical applications. 1. A method of spectrometric analysis comprising:obtaining one or more sample spectra for an aerosol, smoke or vapour sample;analysing the one or more sample spectra so as to classify the aerosol, smoke or vapour sample; andchanging from a first mode of operation to a second different mode of operation so as to classify said aerosol, smoke or vapour sample.2385-. (canceled)386. The method as claimed in claim 1 , wherein the mode of operation for obtaining sample spectra is changed with respect to: (i) the condition of the target or subject that is sampled when obtaining an aerosol claim 1 , smoke or vapour sample; (ii) the type of device used to obtain an aerosol claim 1 , smoke or vapour sample; (iii) the device settings used when obtaining an aerosol claim 1 , smoke or vapour sample; (iv) the device mode of operation when obtaining an aerosol claim 1 , smoke or vapour sample; (v) the type of ambient ion or ionisation source used; (vi) the sampling time over which an aerosol claim 1 , smoke or vapour sample is obtained; (vii) the ion mode used to generate analyte ions for an aerosol claim 1 , smoke or vapour sample; (viii) the spectrometer settings used when obtaining the one or more sample spectra; (ix) the use claim 1 , number and/or type of fragmentation or reaction steps; (x) the use claim 1 , number and/or type of mass or mass to charge ratio separation or filtering steps; (xi) the use claim 1 , number and/or type of ion mobility separation or filtering steps; (xii) the use claim 1 , number and/or type of charge state separation or filtering steps; (xiii) the type of ion detector used ...

Rapid Evaporative Ionisation Mass Spectrometry ("REIMS") and Desorption Electrospray Ionisation Mass Spectrometry ("DESI-MS") Analysis of Swabs and Biopsy Samples

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Apparatus and Methods for an Atmospheric Sampling Inlet for a Portable Mass Spectrometer

Atmospheric sampling system designed to minimize cross-contamination between successive samples acquired by a portable, or handheld, mass spectrometer. Techniques to reduce the overall sample load on portable mass spectrometers having limited pumping capacity, such as capture pumps. Techniques and methods employing simple manual devices and micro vacuum pumps for purging the inlet system of a mass spectrometer. Reduction of cross-contamination between successive samples, permitting a portable mass spectrometer to correctly associate sample positives with specific sample sites or individuals. 1. A pulsed atmospheric sampling system for a portable mass spectrometer comprising:an inlet port for sample injection;a controllable flap or barrier affixed to said inlet port;a capillary line for transfer of said sample injection into said portable mass spectrometer;a pulse valve for controlling the time period of said sample injection through said capillary line;a tee connector located in said capillary line between said inlet port and said pulse valve, where the tee connector is connected to a vacuum source used for purging said sampling system between sample acquisitions.2. The system of in which said vacuum source is created from a fore-vacuum pump connected to said portable mass spectrometer.3. The system of in which said vacuum source is created from a turbomolecular pump located within said portable mass spectrometer.4. The system of in which said vacuum source is created from a capture pump located within said portable mass spectrometer.5. The system of in which said vacuum source is created from a micro vacuum pump weighing less than 1 ounce.6. The system of in which said controllable flap or barrier affixed to said inlet port is controlled manually by the operator's finger.7. The system of in which said controllable flap or barrier affixed to said inlet port is controlled by an electrically operated solenoid.8. A pulsed atmospheric sampling system for a portable mass ...

Analytical device

An analytical device includes: a valve assembly that is connected to a plurality of gas supply conduits; and a gas supply chamber to which a plurality of gases are supplied through the valve assembly, wherein: the valve assembly includes a plurality of valves that regulate flow rates of the plurality of gases supplied to the gas supply chamber through the plurality of gas supply conduits, a fixing member that integrally fixes the plurality of valves, a plurality of first sealing members that seal the plurality of valves against the fixing member, and a retainer that is fastened to the fixing member to integrally press the first sealing member against the fixing member.

Targeted Analysis for Tandem Mass Spectrometry

A tandem mass spectrometer and method are described. Precursor ions are generated in an ion source ( 10 ) and an ion injector ( 21, 23 ) injects ions towards a downstream ion guide ( 50, 60 ) via a single or multi reflection TOF device ( 30 ) that separates ions into packets in accordance with their m/z. A single pass ion gate ( 40 ) in the path of the precursor ions between the ion injector ( 21, 23 ) and the ion guide ( 50, 60 ) is controlled so that only a subset of precursor ion packets, containing precursor ions of interest, is allowed onward transmission to the ion guide ( 50, 60 ). A high resolution mass spectrometer ( 70 ) is provided for analysis of those ions, or their fragments, which have been allowed passage through the ion gate ( 40 ). The technique permits multiple m/z ranges to be selected from a wise mass range of precursors, with optional fragmentation of one or more of the chosen ion species.

Gas Inlet System for Isotope Ratio Analyzer and Method of Determining an Isotope Ratio

A gas inlet system for introducing gas into an isotope ratio analyser, the gas inlet system including a reference system comprising: a first supply of a reference gas having a first known isotope ratio; a supply of a carrier gas, wherein the supplies of reference gas and carrier gas are each connected by respective reference and carrier gas lines to a first mixing junction where the reference gas and carrier gas combine; a mixing zone connected downstream of the first mixing junction wherein the combined reference gas and carrier gas mix together; an exit line for transporting the mixed gas from the mixing zone to the isotope ratio analyser; and an opening on the exit line, wherein the opening is downstream of the mixing zone. Also provided is a method of determining an isotope ratio.

SPECTROMETRIC ANALYSIS OF MICROBES

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population. 1. A method of analysis using mass spectrometry and/or ion mobility spectrometry comprising:automatically sampling a target comprising or consisting of a microbial population using a first device to generate smoke, aerosol or vapour from said target;adding a matrix to said aerosol, smoke or vapour, wherein the matrix is an organic solvent;causing said aerosol, smoke or vapour, or analyte therein, to impact upon a collision surface located within a vacuum chamber of a spectrometer so as to generate a plurality of analyte ions;mass analysing and/or ion mobility analysing said analyte ions in order to obtain spectrometric data; andanalysing said spectrometric data in order to detect a microbe having a particular ribotype or serotype, or to distinguish between two or more microbes having different ribotypes or serotypes in said target.2. A method as claimed in claim 1 , wherein said step of using said first device to generate aerosol claim 1 , smoke or vapour from said target further comprises irradiating said target with a laser.3. A method as claimed in claim 1 , wherein said method comprises a high-throughput screening method.4. A method as claimed in claim 1 , wherein said method is used for drug discovery and/or drug analysis.5. A method as claimed in claim 1 , wherein said matrix is selected from the group consisting of: one or more alcohols; isopropanol; acetone; acetonitrile; tetrahydrofuran; ethyl acetate; ethylene glycol; dimethyl sulfoxide; an aldehyde; a ketone; non-polar molecules; hexane; and ...

Liquid Trap or Separator for Electrosurgical Applications

An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices. 1. Apparatus for mass spectrometry and/or ion mobility spectrometry comprising:a first device arranged and adapted to generate aerosol, smoke or vapour from a target;a mass and/or ion mobility analyser;one or more second devices arranged and adapted to aspirate aerosol, smoke or vapour and/or liquid to or towards the analyser; anda liquid trap or separator located between said first device and said mass and/or ion mobility analyser, wherein said liquid trap or separator is arranged and adapted to capture and/or discard liquid aspirated by said one or more second devices.28-. (canceled)9. Apparatus as claimed in claim 1 , wherein said first device comprises one or more electrodes claim 1 , and wherein said first device is arranged and adapted to generate said aerosol claim 1 , smoke or vapour from said target by contacting said target with said one or more electrodes.10. Apparatus as claimed in claim 9 , wherein said one or more electrodes comprises either: (i) a monopolar device claim 9 , wherein said apparatus optionally further comprises a separate return electrode; (ii) a bipolar device; or (iii) a multi-phase RF device claim 9 , wherein said apparatus optionally further comprises a separate return electrode or electrodes.11. (canceled)12. Apparatus as claimed in claim 9 , further comprising a device arranged and adapted to apply an AC or RF voltage to said one or more electrodes in order to generate said aerosol claim 9 , smoke or vapour.13. (canceled)14. (canceled)15. Apparatus as claimed in claim 1 , whereinsaid first device comprises a laser ...

TURBO MOLECULAR PUMP FOR MASS SPECTROMETER

The invention relates to turbo molecular pumps enabling high pumping speed. The disclosure suggests using one or more cage-like rotor stages to optimize pumping speed on vacuum systems with low gas flows and low ultimate pressures. This allows for a smaller motor as well as smaller overall form factor and makes it well suited, in particular, for compact mass spectrometers and desk-top mass spectrometers. 1. A turbo molecular pump comprising a stationary frame structure and at least one rotor stage located at a low pressure input region , wherein the rotor in the at least one rotor stage rotates with respect to the stationary frame structure during operation and has a central shaft receiving member from which a first rotor blade portion extends substantially radially outward and is connected to a second rotor blade portion which extends substantially paraxially to , and along the central shaft receiving member towards a high pressure output region , wherein , during operation , the first and second rotor blade portions deflect gaseous matter substantially paraxially and radially inwards.2. The turbo molecular pump of claim 1 , wherein the rotor blades in the first rotor blade portion are inclined in relation to a first plane perpendicular to the central shaft receiving member claim 1 , and wherein the rotor blades in the second rotor blade portion are inclined in relation to a substantially hollow-cylindrical envelope contour generated by the second rotor blade portion.3. The turbo molecular pump of claim 1 , further comprising a third rotor blade portion which extends substantially radially outward from the central shaft receiving member and connects to the second rotor blade portion at a position between the low pressure input region and high pressure output region claim 1 , in order to enhance mechanical stability claim 1 , wherein claim 1 , during operation claim 1 , the third rotor blade portion deflects gaseous matter substantially paraxially.4. The turbo ...

AUTOSAMPLER

The invention relates to an autosampler () for obtaining mass spectra from a plurality of fluid samples, in particular gaseous samples. This autosampler () comprises a plurality of containers () comprising sample sources ( ) providing the samples, wherein each one of the containers () provides a docking port () for being connected with a connector () for enabling access to an inside of the respective container ( ) via the connector () when the connector () is connected to the respective docking port ( ) in order to obtain the respective sample from the respective container () via said connector (). Thereby, the connector () is connectable to and detachable from each docking port (). The autosampler () further comprise an ionisation source () for ionising at least a part of the samples to ions, wherein the ionisation source () is fluidly coupled to the connector () for receiving the samples from the containers () via the connector (). Furthermore, the autosampler () comprises a mass analyser () for obtaining the mass spectra from the ions, the mass analyser () being fluidly coupled to the ionisation source () for receiving the ions from the ionisation source () for obtaining the mass spectra from the ions. The ionisation source () is moveable with the connector () within the autosampler () sequentially to each one of the plurality of said containers () for connecting the connector () to the docking port () of the respective container () for collecting the sample from the respective container () for ionising at least a part of the sample to ions and obtaining the mass spectra from the ions. Furthermore, the invention relates to a method for operating the autosampler (). 2. The autosampler according to claim 1 , wherein said mass analyser is moveable together with said ionisation source within said autosampler sequentially to each one of said plurality of said containers for connecting said connector to the docking port of the respective container for collecting said ...

A sample introduction system for mass spectrometry

A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.

APPARATUS FOR MASS ANALYSIS OF ANALYTES BY SIMULTANEOUS POSITIVE AND NEGATIVE IONIZATION

Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidently. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers. 1. An apparatus for the ionization of target molecular analytes , comprising:an electron-impact ion source configured to emit positively-charged molecular ions and fragment ions and operate at 70 eV with a bandspread of 1-2 eV;a trochoidal electron monochromator configured to emit negatively-charged molecularions and fragment ions and operate between 0 to 10 eV, and configured for a bandwidth of ±0.1 eV;a first set of collimating electrodes arranged along a path of an electron beam of the electron-impact ion source;a second set of collimating electrodes arranged along a path of an electron beam of the trochoidal electron monochromator;the trochoidal electron monochromator comprising an electron deflecting region defined by the path of the electron beam of the trochoidal electron monochromator, wherein electrons enter the electron deflecting region at a point that can be offset from their outlet due to the trochoidal motion of electrons;at least one ionization chamber having inlets for at least one of the electron beams and a gaseous molecular stream, the at least one ionization chamber comprising an ion repeller plate and ...

METHODS AND SYSTEMS FOR QUANTIFYING TWO OR MORE ANALYTES USING MASS SPECTROMETRY

Certain embodiments described herein are directed to methods and systems of detecting two or more analytes present in a single system such as a nanoparticle or nanostructure. In some examples, the methods and systems can estimate data gaps and fit intensity curves to obtained detection values so the amount of the two or more analytes present in the single system can be quantified. 1. A method of quantifying a transient event representative of two or more analytes in a transient sample using a mass spectrometer , the method comprising:broadening an ion cloud by differentially decreasing an ion velocity of different analyte ions in an ion cloud in a collision-reaction cell by pressurizing the collision-reaction cell with a gas, the ion cloud comprising ions from a first analyte of the transient sample and ions from a second analyte of the transient sample;providing the broadened ion cloud comprising the different ions of differentially decreased ion velocity from the collision-reaction cell to a mass analyzer fluidically coupled to the collision-reaction cell downstream of the collision-reaction cell to alternately select between the ions from the first analyte and the ions from the second analyte using the mass analyzer;providing the alternately selected ions from the first analyte and the ions from the second analyte from the mass analyzer to a downstream detector fluidically coupled to the mass analyzer to detect the provided ions from the first analyte as first detection values during a detection period and to detect the provided ions from the second analyte as second detection values during the detection period;generating a first intensity curve, using the detected first detection values, that is representative of the first analyte in the sample;generating a second intensity curve, using the detected second detection values, that is representative of the second analyte in the sample;determining an amount of the first analyte in the transient sample using the ...

Sample Preparation Apparatus and Method for Elemental Analysis Spectrometer

A sample preparation apparatus for an elemental analysis system comprising a sample combustion and/or reduction and/or pyrolysis arrangement for receiving a sample of material to be analysed, and producing therefrom a sample gas flow containing atoms, molecules and/or compounds; a gas chromatography (GC) column into which the sample gas flow is directed; a heater for heating at least a part of the GC column; and a controller for controlling the heater. The controller is configured to control the heater so as to increase the temperature of at least the part of the GC column whilst the sample gas flow in the GC column elutes. 1. A sample preparation apparatus for an elemental analysis system ,comprising:a sample combustion and/or reduction and/or pyrolysis arrangement for receiving a sample of material to be analyzed, and producing therefrom a sample gas flow containing atoms, molecules and/or compounds;a gas chromatography (GC) column into which the sample gas flow is directed;a heater for heating at least a part of the GC column; anda controller for controlling the heater;the controller being configured to control the heater so as to increase the temperature of at least the part of the GC column whilst the sample gas flow in the GC column elutes.2. The sample preparation apparatus of claim 1 , further wherein the controller is configured to control the heater so that the temperature of at least the part of the GC column is increased after a first one or more species of atoms claim 1 , molecules or compounds have passed the GC column.3. The sample preparation apparatus of claim 1 , wherein the controller is configured to control the heater so that the temperature changes substantially linearly between a start temperature Tand an end temperature T.4. The sample preparation apparatus of claim 1 , wherein the controller is configured to control the heater so that the temperature changes substantially non-linearly between a start temperature Tand an end temperature T.5. ...

Inlet Sampling Method and Device

An inlet apparatus is disclosed. The apparatus may include a first conduit for sampling, and a second and third conduit for directing flow throughout the inlet apparatus. Flow may be induced in two opposite directions through the second conduit, which affect the flow of gas through the first conduit for sampling. The various conduits of the apparatus may be connected to a device for inducing flow in different directions. The duration of the flow in a particular direction affects the amount of sample gas that enters a detection device. 121-. (canceled)22. An inlet assembly , comprising:a first pathway partially defined by a first conduit;a second pathway partially defined by one or more directional flow conduits that are coupled to a second and a third conduit;wherein the one or more directional flow conduits comprise one or more flow regulators, the flow regulators being capable of operating in a first position in which fluid circulates through the second pathway from the third conduit to the second conduit and back to the third conduit and in which no fluid from an ambient environment passes into the device.23. The inlet assembly of claim 22 , wherein the one or more flow regulators comprise one or more valves.24. The inlet assembly of claim 22 , wherein the second conduit is generally concentric to the first conduit.25. The inlet assembly of claim 22 , wherein the third conduit is generally concentric to the second conduit.26. The inlet assembly of claim 25 , wherein the second pathway is further partially defined by an interspace between the second and first conduits when the one or more flow regulators are in the first position.27. The inlet assembly of claim 26 , wherein the second pathway is further partially defined by an interspace between the third and second conduits when the one or more flow regulators are in the first position.28. The inlet assembly of claim 22 , wherein the one or more flow regulators being capable of operating in a second position in ...

Method for Transmitting Ions and Carrier Gas between Mutually Facing Curved Electrodes

A method for transmitting ions entrained in a flowing carrier gas into and through a gap defined by a pair of mutually facing curved electrodes comprises: inputting the ions and flowing gas into the gap through an ion inlet orifice of a first one of the pair of electrodes, the ion inlet orifice comprising an orifice wall, an orifice inlet end and an orifice outlet end, the orifice wall being smoothly convexly curved between the inlet end and the outlet end, wherein a width of the gap and a flow rate of the carrier gas through the ion inlet orifice and gap are such that the gas flow is laminar within the ion inlet orifice and gap. 1. A method for transmitting ions entrained in a flowing carrier gas into and through a gap defined by a pair of mutually facing curved electrodes , the method comprising:inputting the ions and flowing gas into the gap through an ion inlet orifice of a first one of the pair of electrodes, the ion inlet orifice comprising an orifice wall, an orifice inlet end and an orifice outlet end, the orifice wall being smoothly convexly curved between the inlet end and the outlet end, wherein a width of the gap and a flow rate of the carrier gas through the ion inlet orifice and gap are such that the gas flow is laminar within the ion inlet orifice and gap.2. A method as recited in claim 1 , wherein the gap width is less than or equal to 0.75 mm.3. A method as recited in claim 1 , wherein the gap width is less than or equal to 0.25 mm.4. A method as recited in claim 1 , wherein the gap width is constant.5. A method as recited in claim 1 , wherein a face of the first one of the pair of electrodes that faces the second one of the pair of electrodes is concavely curved and a face of the second one of the pair of electrodes that faces the first one of the pair of electrodes is convexly curved.6. A method as recited in claim 1 , wherein the electrodes are electrodes of a High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) apparatus.7. A method ...

INLET INSTRUMENTATION FOR ION ANALYSER COUPLED TO RAPID EVAPORATIVE IONISATION MASS SPECTROMETRY ("REIMS") DEVICE

An apparatus is disclosed comprising a first device for generating aerosol, smoke or vapour from one or more regions of a target, an inlet conduit to an ion analyser or mass spectrometer, the inlet conduit having an inlet through which the aerosol, smoke or vapour passes, and a Venturi pump arrangement arranged and adapted to direct the aerosol, smoke or vapour towards the inlet. 1. An apparatus comprising:a first device arranged and adapted to emit a stream of electrically charged droplets towards a target in use;a transfer capillary arranged and adapted to transfer ions generated from said target towards an ion analyser or mass spectrometer; anda heating device arranged and adapted to heat either: (i) a capillary of said first device; (ii) said stream of electrically charged droplets emitted from said first device; (iii) said target; and/or (iv) said transfer capillary.2. An apparatus as claimed in claim 1 , wherein said first device comprises a Desorption Electrospray Ionisation (“DESI”) device.3. An ion inlet device as claimed in claim 1 , wherein said heating device comprises a heater.4. An ion inlet device as claimed in claim 3 , wherein said heater comprises a wire heater.5. An ion inlet device as claimed in claim 1 , wherein said heating device is arranged and adapted to heat said capillary of said first device claim 1 , said stream of electrically charged droplets emitted from said first device claim 1 , said target or said transfer capillary to a temperature of above ambient temperature claim 1 , and/or to a temperature of at least 30° C. claim 1 , 50° C. claim 1 , 100° C. claim 1 , 200° C. claim 1 , 300° C. claim 1 , 400° C. claim 1 , 500° C. or greater than 500° C.6. An ion inlet device as claimed in claim 1 , wherein said heating device is located adjacent an inlet to said ion analyser or mass spectrometer.7. An ion inlet device as claimed in claim 6 , wherein said inlet forms the entrance to a first vacuum stage of said ion analyser or mass ...

IONIZATION CHAMBER WITH TEMPERATURE-CONTROLLED GAS FEED

The invention relates to an ionization chamber for connection to a mass spectrometer. The ionization chamber has a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and leads into a gas outlet. A temperature-control device is positioned along the gas channel and ensures that a gas flowing in the gas channel is brought to a specific temperature, i.e. it is heated or cooled, before it enters the ionization chamber. The temperature-control block has a formed part into which a structure of the gas channel is incorporated and which is fabricated by means of a sol-gel process, for example out of a glass or ceramic material. 1. An ionization chamber to be connected to a mass spectrometer , said ionization chamber having a temperature-control block with a gas inlet and a gas channel which starts at the gas inlet and discharges into a gas outlet , and further having a temperature-control device being positioned along the gas channel to ensure that a gas flowing in the gas channel is brought to a specific temperature before it enters the ionization chamber , wherein the temperature-control block comprises a formed part into which the structure of the gas channel is incorporated and which is manufactured by means of a sol-gel process.2. The ionization chamber according to claim 1 , wherein the formed part is made of a glass or ceramic material.3. The ionization chamber according to claim 1 , wherein the formed part has a disk-shaped substrate which is joined together with another disk-shaped substrate on a flat face to create the temperature-control block.4. The ionization chamber according to claim 3 , wherein the structure of the gas channel comprises a pattern of indentations incorporated on the joining side of the formed part.5. The ionization chamber according to claim 3 , wherein the opposite face of the second disk-shaped substrate is smooth and planar and closes off the opposing channel structure of the formed part on one face ...

METHODS AND DEVICES FOR EVALUATING THE CONTENTS OF MATERIALS

Methods for determining the hardness and/or ductility of a material by compression of the material are provided as a first aspect of the invention. Typically, compression is performed on multiple sides of a geologic material sample in a contemporaneous manner. Devices and systems for performing such methods also are provided. These methods, devices, and systems can be combined with additional methods, devices, and systems of the invention that provide for the analysis of compounds contained in such samples, which can indicate the presence of valuable materials, such as petroleum-associated hydrocarbons. Alternatively, these additional methods, devices, and systems can also stand independently of the methods, devices, and systems for analyzing ductility and/or hardness of materials. 1. A method for analyzing the mechanical strength of a material from a geologic formation comprising:a. placing a sample of a material obtained from a geologic formation into a container which (i) isolates the sample and any gasses released from the sample from the environment; (ii) is adapted to be compressed without release of gasses contained in the container; and (iii) comprises a portion that is selectively accessible by a flow path component through which gasses in the container can be removed from the container for further analysis;b. subjecting the container to one or more compression forces, the one or more compression forces having sufficient strength to (a) compress the container without causing the release of any such gas from the container and (b) cause the sample in the container to be disrupted and thereby promote release of gas from the sample;c. determining the amount of compression of the container, the compression of the container being proportional to the strength of the sample, andd. assessing the mechanical strength of material from the geologic formation by evaluating the compression of the container.2. The method of claim 1 , wherein the one or more compression ...

GAS INLET SYSTEM FOR ISOTOPE RATIO SPECTROMETER

A gas inlet system for an isotope ratio spectrometer and a method for coupling analyte gas to an isotope ratio spectrometer are disclosed. A variable volume reservoir is located between a supply of analyte gas and a spectrometer. The reservoir's internal volume is controllably adjusted at a pre-determined rate to generate a defined flow of analyte gas or mixture to or from the reservoir. Analyte gas and carrier gas are taken up by the reservoir on increasing the reservoir's internal volume and then expelled from the reservoir to the spectrometer on decreasing the reservoir's internal volume. An open split can be used together with the reservoir to facilitate splitting away and hence dilution of analyte within the reservoir. A method for cleaning the gas inlet system is provided, which involves flushing the system with carrier gas. 1. A gas inlet system for an isotope ratio spectrometer , comprising:a first supply of analyte gas;a variable volume reservoir;a first analyte gas supply line between the first supply of analyte gas and the variable volume reservoir for selectively supplying the analyte gas to the variable volume reservoir;a reservoir supply line for supplying the contents of the variable volume reservoir to the spectrometer;a volume varying means for adjusting the volume inside the variable volume reservoir; anda controller configured to generate a command so as to cause the volume varying means to adjust the volume inside the reservoir at a pre-determined rate, so as to control the flow rate of analyte gas output to the isotope ratio spectrometer as the volume of the variable volume reservoir is adjusted.2. The gas inlet system of claim 1 , further comprising:a carrier gas supply; anda carrier gas supply line between the carrier gas supply and the spectrometer,wherein the carrier gas supply line is selectively connected with the reservoir supply line so as to allow carrier gas to pass from the carrier gas supply into the variable volume reservoir.3. The ...

METABOLITE BIOMARKERS FOR STAGING COLORECTAL CANCER

This document provides methods and materials for assessing metabolites in a sample from a mammal (e.g., human) for determining the nature and extent of colorectal cancer (CRC) metastasis. For example, the document relates to the diagnosis, staging and prognosis of CRC in a mammal. 1. A method of characterizing metastatic colorectal cancer comprising:(a) obtaining a mammalian biological sample;(b) analyzing the biological sample from the mammal with gas chromatography-mass spectrometry to determine the level(s) of one or more core biomarkers set forth in Table 2B and Table 2D; and(c) comparing the level(s) of the one or more core biomarkers in the sample to metastatic and/or normal reference levels of the one or more core biomarkers in order to assess the characterize metastatic disease in the mammal.2. The method of claim 1 , wherein step (b) comprises analyzing the levels of two claim 1 , three claim 1 , four claim 1 , five claim 1 , six claim 1 , seven claim 1 , eight claim 1 , nine claim 1 , ten claim 1 , eleven claim 1 , twelve claim 1 , thirteen claim 1 , fourteen claim 1 , fifteen claim 1 , sixteen claim 1 , seventeen claim 1 , eighteen claim 1 , nineteen claim 1 , twenty claim 1 , twenty-five claim 1 , thirty claim 1 , thirty-five claim 1 , forty claim 1 , fifty or all of the core biomarkers in Table 2B and Table 2D.3. The method of claim 1 , wherein the biological sample is a body fluid.4. The method of claim 3 , wherein the body fluid is a urine sample claim 3 , a blood sample claim 3 , a serum sample or a plasma sample.5. The method of claim 1 , wherein analyzing comprises determining one or more core markers in Table 2B.6. The method of claim 5 , wherein analyzing comprises determining all the core markers in Table 2B.7. The method of claim 1 , wherein analyzing comprises determining one or more core markers in Table 2D.8. The method of claim 7 , wherein analyzing comprises determining all the core markers in Table 2D.9. The method of claim 1 , wherein ...

IONIZATION PROBE ASSEMBLIES

The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose. 1. An ionization probe assembly , comprising:at least one probe mounting structure;at least one probe that is movably coupled to the probe mounting structure, which probe is configured to discontinuously introduce sample aliquots into an ion source housing; and,at least one probe conveyance mechanism operably connected to the probe, which probe conveyance mechanism is configured to convey the probe between at least a first position and at least a second position, wherein the first position is substantially electrically isolated from the second position.2. The ionization probe assembly of claim 1 , wherein the probe mounting structure comprises at least one view port.3. The ionization probe assembly of claim 1 , comprising at least one cover operably connected to the probe mounting structure.4. An electrospray ion source housing comprising the ionization probe assembly of .5. A mass spectrometer comprising the electrospray ion source housing of .6. The ionization probe assembly of claim 1 , wherein the probe mounting structure comprises an ion source housing back plate that is configured to operably connect to an ion source housing.7. The ionization probe assembly of claim 6 , wherein the ion source housing back plate comprises at least one alignment feature that is structured to align the ion source housing back plate relative to the ion source housing when the ion source housing back plate operably connects to the ion source housing.8. The ionization probe assembly of claim 1 , wherein at least one channel is disposed through a length of the probe.9. The ionization probe assembly of claim 8 , wherein the probe comprises at least one sprayer needle that fluidly communicates with the channel.10. The ionization probe assembly of claim 8 , wherein at least one nebulizer gas source and/or nebulizer gas ...

Multi-dopant permeation tube

Aspects and embodiments of the present invention are directed to spectrometry systems and for apparatus and methods for delivering dopants to same. In one example, there is provided a dopant delivery device configured to supply dopants to a spectrometry system comprising a tube including a first chamber 5 and a second chamber, a first dopant source included in the first chamber, and a second dopant source included in the second chamber.

SYSTEMS AND METHODS FOR ANALYZING A SAMPLE

The invention generally relates to systems and methods for sample analysis. In certain embodiments, the invention provides systems for analyzing a sample that include an electric source, a vacuum chamber including a conducting member, in which the conducting member is coupled to the electric source, a sample introduction member coupled to the vacuum chamber, and a mass analyzer. The system is configured such that a distal end of the sample introduction member resides within the vacuum chamber and proximate the conducting member, such that an electrical discharge may be produced between the sample introduction member and the conducting member. A neutral gas that has been introduced into the vacuum chamber interacts with the generated discharge, producing ions within the vacuum chamber that are subsequently transferred into the mass analyzer in the vacuum chamber. 120-. (canceled)21. A sample analysis system , the system comprising:a discontinuous sample introduction interface;an ionization mechanism comprising a tube and an electrode; anda mass analyzer for a miniature mass spectrometer that is located in a vacuum chamber that is separate and distinct from and operably associated with the ionization mechanism, wherein the ionization mechanism is positioned between the discontinuous sample introduction interface and the mass analyzer to interact with a sample gas after it has passed through the discontinuous sample introduction interface and produce ions of the sample gas that are received by the mass analyzer from the separate and distinct ionization mechanism, and wherein operation of the ionization mechanism is synchronized with opening and closing of the discontinuous sample introduction interface.22. The system according to claim 21 , wherein the mass analyzer is selected from the group consisting of: a quadrupole ion trap claim 21 , a rectalinear ion trap claim 21 , a cylindrical ion trap claim 21 , a ion cyclotron resonance trap claim 21 , and an orbitrap.23. ...

Coupling device for mass spectrometry apparatus

An object of the present invention is to provide a technology that enables highly sensitive atmospheric-pressure real-time mass spectrometry of a volatile substance. The present invention provides a coupling device for a mass spectrometry apparatus that is an interface member to be connected to an atmospheric-pressure real-time mass spectrometry apparatus, the coupling device including (A) an excitation gas introducing port, a sample gas introducing port, and an ionized sample gas discharging port, and (B) a channel through which the excitation gas introducing port and the ionized sample gas discharging port are in communication, and (C) a space for mixing excitation gas and sample gas being formed in a region of a portion of the channel recited in (B), by the coupling device having a structure in which the sample gas introducing port and the channel recited in (B) are in communication. 2. The coupling device for a mass spectrometry apparatus according to claim 1 ,wherein the coupling device is an interface member for being connected between an excitation gas ejecting port of an ion source using a principle of a DART method and an ionized sample gas collecting port of a mass spectrometer.3. The coupling device for a mass spectrometry apparatus according to claim 1 ,wherein the space recited in (C) is a space formed in a channel portion having a linear-tube shape in the channel recited in (B).4. The coupling device for a mass spectrometry apparatus according to claim 1 ,wherein the space recited in (C) is a space formed such that a cross-sectional area of the channel recited in (B) on the excitation gas introducing port side is relatively large compared with the channel on the ionized sample gas discharging port side.5. (canceled)6. An atmospheric-pressure real-time mass spectrometry apparatus provided with the coupling device for a mass spectrometry apparatus according to .7. A mass spectrometry method for performing mass spectrometry of a volatile substance in real ...

Method and system for determining the concentration of an analyte in a fluid sample

A method and system are provided for detecting the concentration of an analyte in a fluid sample. The method and system involve analysis of a volatilized, ionized fluid sample using a mass spectrometer or other ionic analyte detection device that provides a signal proportional in intensity to the quantity of ionized analyte detected. The improvement involves replacement of a necessary non-analyte component in the fluid sample with a substitute component that serves the same purpose as the original component but is either more volatile than the original component and/or the analyte or undergoes a reaction to provide lower molecular weight reaction products, and results in an increased intensity in signal and signal-to-noise ratio. Acoustic fluid ejection is a preferred method of generating nanoliter-sized droplets of fluid sample that are then volatilized, ionized, and analyzed. Also provided are zwitterionic compounds suitable as the substitute components that when ionized and heated decompose to provide carbonic dioxide, a nitrogenous species such as ammonia, an amine, or nitrogen gas, and a volatile aromatic compound.

ION MOBILITY SPECTROMETER SYSTEM

An ion mobility spectrometer system is disclosed. In one aspect, the system includes a gas chromatograph, first and second ion mobility spectrometers, and a sample feed device that feeds a sample from the gas chromatograph to the first and second ion mobility spectrometers. The sample feed device includes an inner chamber, first and second sample outlets for outputting the sample from the gas chromatograph to the first and second ion mobility spectrometers, respectively, and a gas inlet for inputting a gas into the sample feed device. The system detects and identifies molecules at improved resolution and enhanced molecule information. The system detects positive and negative ions, interrelates positive-mode and negative-mode spectrums, and separates substances. 1. An ion mobility spectrometer system , comprising:a gas chromatograph configured to separate compounds and output a sample;a first ion mobility spectrometer and a second ion mobility spectrometer, each configured to identify ionized molecules; and an inner chamber;', 'a first sample outlet and a second sample outlet for outputting the inputted sample to the first ion mobility spectrometer and the second ion mobility spectrometer, respectively; and', 'a gas inlet for inputting a gas into the sample feed device., 'a sample feed device configured to input the sample, the sample feed device comprising2. The ion mobility spectrometer system of claim 1 , further comprising a gas source connected to the gas chromatograph to supply a carrier gas to the gas chromatograph.3. The ion mobility spectrometer system of claim 1 , further comprising a pump inputting gas through the gas inlet of the sample feed device into the sample feed device claim 1 , a first portion of the gas flowing from the sample feed device through the first sample outlet into the first ion mobility spectrometer claim 1 , a second portion of the gas flowing from the sample feed device through the second sample outlet into the second ion mobility ...

APPARATUS FOR MASS ANALYSIS OF ANALYTES BY SIMULTANEOUS POSITIVE AND NEGATIVE IONIZATION

Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidentally. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers. 1. An apparatus for the ionization of target molecular analytes , comprising:an electron-impact ion source configured to emit positively-charged molecular ions and fragment ions and operate at 70 eV with a bandspread of 1-2 eV;a trochoidal electron monochromator configured to emit negatively-charged molecularions and fragment ions and operate between 0 to 10 eV, and configured for a bandwidth of +/−0.1 eV;a first set of collimating electrodes arranged along a path of an electron beam of the electron-impact ion source;a second set of collimating electrodes arranged along a path of an electron beam of the trochoidal electron monochromator;the trochoidal electron monochromator comprising an electron deflecting region defined by the path of the electron beam of the trochoidal electron monochromator, wherein electrons enter the electron deflecting region at a point that can be offset from their outlet due to the trochoidal motion of electrons;at least one ionization chamber having inlets for at least one of the electron beams and a gaseous molecular stream, the at least one ionization chamber comprising an ion repeller plate ...

ION ANALYZER

An ion analyzer that generates product ions from precursor ions derived from a sample component and analyzes the product ions includes a reaction chamber () into which the precursor ion is introduced, a radical generation chamber (), a material gas supply source () configured to introduce material gas into the radical generation chamber (), a vacuum evacuator () configured to evacuate the radical generation chamber (), a vacuum discharge unit () configured to generate a vacuum discharge in the radical generation chamber (), a radical irradiation unit () configured to irradiate an inside of the reaction chamber () with radicals generated from the material gas in the radical generation chamber (), and a separation and detection () configured to separate and detect product ions generated from the precursor ion by reaction with the radicals according to at least one of a mass-to-charge ratio and ion mobility. 1. An ion analyzer that generates product ions from a precursor ion derived from a sample component and analyzes the product ions , the ion analyzer comprising:a reaction chamber into which the precursor ion is introduced;a radical generation chamber;a material gas supply source configured to introduce material gas into the radical generation chamber;a vacuum evacuator configured to evacuate the radical generation chamber;a vacuum discharge unit configured to generate vacuum discharge in the radical generation chamber;a radical irradiation unit configured to irradiate an inside of the reaction chamber with radicals generated from the material gas in the radical generation chamber; anda separation and detection unit configured to separate and detect product ions generated from the precursor ion by reaction with the radicals according to at least one of a mass-to-charge ratio and ion mobility.2. The ion analyzer according to claim 1 , wherein the radicals include at least one of hydroxyl radical claim 1 , oxygen radical claim 1 , nitrogen radical claim 1 , and ...

Controlling Gas-Phase Ion Interactions

A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property; an ion mobility separation device for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply connected to said ion mobility separation device for supplying gas into said ion mobility separation device; and a control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation device as a function of time. 1. A mass spectrometer or ion mobility spectrometer comprising:a first device for separating ions or molecules according to a physicochemical property;an ion mobility separation or filter device for receiving and separating or filtering at least some of said ions, or ions derived from said molecules, according to their ion mobility;a gas supply connected to said ion mobility separation or filter device for supplying gas into said ion mobility separation or filter device; anda control system configured to adjust said gas supply so as to change the composition of gas within the ion mobility separation or filter device as a function of time.2. The method of claim 1 , wherein the ion mobility separation or filter device is configured to drive ions of different ion mobility from an entrance of the device towards an exit of the device at different rates so as to separate or filter ions according to their drift time along or through the device.3. A spectrometer as claimed in claim 1 , wherein the control system is configured to vary the gas composition in said ion mobility separation or filter device dynamically based on the separation or elution time in said first device.4. A spectrometer as claimed in claim 1 , wherein the gas composition in the ion mobility separation or filter device is controlled based on the ions or molecules eluting from the first device and passing into ...

Contamination Filter for Mass Spectrometer

Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss. 18-. (canceled)9. A system for analyzing ions comprising:an ion source;a low resolution, high transmission ion mobility spectrometer for reducing contamination having an input end for receiving ions from the ion source and an output end, the ion mobility spectrometer having an internal operating pressure, electrodes, and at least one voltage source for providing DC and RF voltages to the electrodes;a mass spectrometer in fluid communication with the ion mobility spectrometer for receiving the ions from the output end of ion mobility spectrometer; and a controller operably coupled to the ion mobility spectrometer and configured to control the DC and RF voltages; andwherein the ion mobility spectrometer is configured such that a ratio of a residence time of the ions through the ion mobility spectrometer to a product of gap height between electrodes of the ion mobility spectrometer and a maximum separation voltage applied to the electrodes of the ion mobility spectrometer being less than 0.002 second/(meter*volt).10. The system of claim 9 , wherein the spectrometer is configured such that the ratio of the residence time of the ions through the ion mobility spectrometer to the product of gap height between electrodes of the ion mobility spectrometer and the maximum separation voltage applied to the electrodes of the ion mobility spectrometer being less than 0.0015 second/(meter*volt).11. The system of claim 9 , wherein the residence time of the ions is less than 100 milliseconds.12. The system ...

LASER ABLATION SPECTROMETRY SYSTEM

This disclosure provides systems, methods, and apparatus related to laser ablation spectrometry systems. In one aspect, a system comprises a microscope, a laser, a continuous flow probe, and a gas confinement device. The laser is positioned to emit light through an objective lens of the microscope. The continuous flow probe is coupled to a spectrometer. An end of the continuous flow probe is positioned proximate a sample and between the sample and the objective lens. The gas confinement device defines a gas inlet, a chamber, a platform, a wall surrounding the platform, a plurality of vents, and a plurality of channels. Each of the plurality of vents is positioned to direct a gas substantially parallel to the platform, and each of the plurality of vents is defined in the wall. The plurality of channels is operable to provide fluid communication between the chamber and the plurality of vents. 1. A system comprising:a microscope;a laser, the laser being positioned to emit light through an objective lens of the microscope;a continuous flow probe coupled to a spectrometer, an end of the continuous flow probe positioned proximate a sample and between the sample and the objective lens; and a gas inlet,', 'a chamber,', 'a platform, the platform operable to support a sample,', 'a plurality of vents, each of the plurality of vents being positioned to direct a gas substantially parallel to the platform, and', 'a plurality of channels, the plurality of channels operable to provide fluid communication between the chamber and the plurality of vents., 'a gas confinement device, the gas confinement device defining2. The system of claim 1 , wherein each of the plurality of vents are defined in a wall surrounding the platform claim 1 , wherein the plurality of vents are symmetrically arranged around the platform claim 1 , and wherein the symmetrical arrangement is substantially circular.3. The system of claim 1 , wherein each of the plurality of vents is positioned about 0.25 ...

MULTI-DOPANT PERMEATION TUBE

Aspects and embodiments of the present invention are directed to spectrometry systems and for apparatus and methods for delivering dopants to same. In one example, there is provided a dopant delivery device configured to supply dopants to a spectrometry system comprising a tube including a first chamber and a second chamber, a first dopant source included in the first chamber, and a second dopant source included in the second chamber. 1. A dopant delivery device configured to be mounted within a dopant chamber of a spectrometry system and to introduce dopant into a carrier gas in the dopant chamber , the dopant delivery device comprising:a tube including a first chamber and a second chamber, the first chamber separated from the second chamber by a first plug;a first dopant included in the first chamber; anda second dopant included in the second chamber.2. The dopant delivery device of claim 1 , wherein the tube includes a first end and a second end and the first plug is disposed in the tube at a position remote from both the first end and the second end.3. The dopant delivery device of claim 2 , wherein the first chamber is defined by a wall of the tube claim 2 , the first plug claim 2 , and a second plug inserted into a portion of the tube proximate the first end of the tube.4. The dopant delivery device of claim 3 , wherein the second chamber is defined by the wall of the tube claim 3 , a third plug inserted into a portion of the tube proximate the second end of the tube claim 3 , and by the first plug.5. The dopant delivery device of claim 4 , wherein a bore is defined in one of the second plug and the third plug.6. The dopant delivery device of claim 1 , wherein the first dopant source comprises dichloromethane liquid.7. The dopant delivery device of claim 6 , wherein the wall of the tube defining the first chamber is permeable to dichloromethane vapor.8. The dopant delivery device of claim 1 , wherein the second dopant source comprises an ammonia solid.9. The ...

PORTABLE ELECTRONIC DEVICE FOR THE ANALYSIS OF A GASEOUS COMPOSITION

An electronic device for analyzing a gas composition, which is present in an environment A at an environment pressure Pa, is described. The device is portable and comprises a gas sampling module an ion filtering module and an ion detecting module The sampling module is configured to adjust an input gaseous flow Fi of gaseous particles from the environment A and an output gaseous flow Fo so as to reproduce inside the sampling module a gas composition representative of the gas composition to be analyzed. In addition, the sampling module is configured to ionize said gaseous particles and to emit the ions produced, so as to generate an ion flow I having an ion composition representative of the gas composition to be analyzed. The ion filtering module is operatively connected to the sampling module to receive the ion flow I, and is configured to controllably select at least one type of ions present in the ion flow I and to generate a corresponding at least one homogeneous ion beam I′, having an intensity representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. The ion detecting module is operatively connected to the ion filtering module to receive the at least one ion beam I′, and is configured to measure the intensity of such least one ion beam I′ and to generate a corresponding electric signal S representative of the concentration of the corresponding gas particle in the gaseous composition to be analyzed. 1. An electronic device for analyzing a gaseous composition , which is present in an environment (A) at an environment pressure (Pa) , the device being portable and suitable to be placed in said environment (A) , and comprising:a gas sampling module, configured to adjust an input gas flow (Fi) of gas particles from said environment (A) and an output gas flow (Fo), so as to reproduce inside the sampling module a gaseous composition representative of said gaseous composition to be analyzed, and to ionize said gas ...

Collision Cell

A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value. 1. A method of operating a gas-filled collision cell in a mass spectrometer , the collision cell having a longitudinal axis extending between a first end and a second end , the method comprising:causing ions to enter the collision cell through the first end in a forward direction;generating a trapping field within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis;ejecting trapped ions from the collision cell in the forward direction through the second end;causing the ejected ions to re-enter the collision cell in the reverse direction through the second end; andejecting ions from the collision cell in a reverse direction through the first end, wherein the method further comprises providing a DC potential gradient, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause ions to exit the collision cell in the reverse direction, wherein the direction and magnitude of the DC potential gradient remains the same during the steps of generating the ...

SAMPLE QUANTITATION USING A MINIATURE MASS SPECTROMETER

The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed. 110-. (canceled)11. A method for analyzing a sample and an internal standard in a miniature mass spectrometer , the method comprising:generating sample ions and internal standard ions;simultaneously transferring the sample and internal standard ions through a discontinuous sample introduction interface into a first ion trap of a miniature mass spectrometer;closing the discontinuous sample introduction interface;sequentially transferring the sample and internal standard ions to a second ion trap of the miniature mass spectrometer; andsequentially analyzing the sample and internal standard ions in the second ion trap.12. The method according to claim 11 , wherein the first ion trap is a linear quadrupole ion trap.13. The method according to claim 11 , wherein the second ion trap is a rectilinear ion trap.14. The method according to claim 11 , wherein generating the ions is by a technique that utilizes an ionization source that operates at atmospheric pressure and temperature.15. The method according to claim 11 , wherein generating the ions is by a technique that utilizes a direct ambient ionization/sampling technique.16. The method according to claim 15 , wherein the technique is paper spray ionization.17. The method according to claim 11 , wherein the first and second ions are transferred to the second ion trap within a single scan cycle.18. ...

ION SOURCE

A method of ionisation is disclosed in which a sample is heated such that analyte is released from the sample. Analyte released from the sample is accumulated, and then the accumulated analyte is passed to an ionisation region where the analyte is ionised. 1. A method of ionisation comprising:heating a sample such that analyte is released from the sample;accumulating analyte released from the sample; and thenpassing the accumulated analyte to an ionisation region and ionising the analyte.2. A method as claimed in claim 1 , comprising:accumulating analyte released from the sample during a first period of time; andpassing the accumulated analyte to the ionisation region during a second period of time that follows the first period of time, wherein the second period of time is shorter than the first period of time.3. A method as claimed in claim 1 , comprising heating the sample and accumulating analyte released from the sample in one or more heating and/or accumulation regions.4. A method as claimed in claim 3 , wherein the method comprises:operating a first inlet valve and a first outlet valve in a closed state while accumulating the analyte; andpassing the accumulated analyte to the ionisation region by opening the first inlet valve and the first outlet valve.5. A method as claimed in claim 4 , wherein the method comprises:operating a bypass valve in an open state while accumulating the analyte; andoperating the bypass valve in a closed state while passing the accumulated analyte to the ionisation region.6. A method as claimed in claim 4 , wherein the method comprises:operating the first inlet valve in an open state and operating a second outlet valve in an open state before accumulating the analyte and/or after passing the accumulated analyte to the ionisation region.7. A method as claimed in claim 6 , wherein the method comprises:operating a second inlet valve in an open state, operating the second outlet valve in an open state, operating the first inlet valve in a ...

Method and System for Decoupling a Capillary Column from a Gas Chromatography-Mass Spectrometry (GC-MS) System

A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position. 2. The column-sealing tool of claim 1 , wherein the sealing element is fabricated from a material selected from the group consisting of: silicone rubber claim 1 , a fluorinated elastomer claim 1 , and a polyimide.3. The column-sealing tool of claim 1 , comprising an actuator for selectably actuating the sealing element between the non-sealing position and the sealing position.4. The column-sealing tool of claim 3 , wherein the actuator is a linear actuator comprising a cam mechanism claim 3 , and wherein actuating the sealing element between the non-sealing position and the sealing position comprises compressing the sealing element along a longitudinal axis of the column-sealing tool such that the sealing element undergoes an elongation in a direction that is normal to the longitudinal axis.5. The column-sealing tool of claim 4 , wherein the cam mechanism comprises a stationary cam and a moving cam that is rotatable relative to the stationary cam claim 4 , and wherein rotating the moving cam changes a spacing between the stationary cam and the moving cam along the longitudinal direction.6. The column-sealing tool of claim 3 , wherein the actuator is a rotational actuator comprising a cam mechanism claim 3 , and wherein ...

METHOD FOR ANALYZING EVOLVED GAS AND EVOLVED GAS ANALYZER

Disclosed herein is an evolved gas analyzer and a method for analyzing evolved gas, the apparatus enhancing detection accuracy for gas component without providing the apparatus in a large size. The apparatus includes a heating unit evolving a gas component by heating a sample, a detecting means detecting the gas component, a gas channel connecting the heating unit to the detecting means, the gas channel through which mixed gas of the gas component and carrier gas flows, wherein the gas channel includes a branching channel being open to outside and including a discharge flow rate controlling device, and a flow rate control device controlling the discharge flow rate controlling device based on a detection signal received from the detecting means so as to control the detection signal to be within a predetermined range. 1. An evolved gas analyzer comprising:a heating unit evolving a gas component by heating a sample,a detecting means detecting the gas component evolved by the heating unit, anda gas channel making connection between the heating unit and the detecting means in which mixed gas of the gas component and carrier gas, carrying the gas component to the detecting means, flows,wherein the gas channel comprises a branching channel open to outside, the branching channel comprises a discharge flow rate controlling device, adjusting flow rate of the mixed gas discharged to outside, and the evolved gas analyzer further comprises a flow rate control device controlling the discharge flow rate controlling device based on a detection signal from the detecting means so as to bring the detection signal to be within a given range.2. The apparatus of claim 1 , further comprising a heat retaining unit claim 1 , heating or retaining heat of the gas channel or the branching channel.3. The apparatus of claim 1 , further comprising:a forced discharge unit, discharging the mixed gas flowing in the branching channel by force, on a discharge side of the branching channel.4. The ...

METHOD FOR ANALYZING EVOLVED GAS AND EVOLVED GAS ANALYZER

Disclosed herein is a method for analyzing evolved gas and an evolved gas analyzer, the method correcting detection sensitivity differences in analysis devices, day-to-day variations thereof, thereby quantifying a measurement target with high accuracy. The method for analyzing evolved gas of the apparatus including: a sample holder; a heating unit evolving a gas component; an ion source generating ions by ionizing the gas component; a mass spectrometer detecting the gas component; and a gas channel through which mixed gas flows, the method including: operating a discharged flow rate controlling process of controlling a flow rate of the mixed gas discharged to outside; operating a sample holder cooling process of cooling the sample holder by bringing the sample holder into contact with a cooling unit; and operating a correction process including: correcting a mass spectrum position; calculating a sensitivity correction factor; and calculating a heating correction factor. 1. A method for analyzing evolved gas , using apparatus , comprising:a sample holder, holding a sample;a heating unit, receiving the sample holder therein, and evolving a gas component by heating the sample;an ion source, generating ions by ionizing the gas component evolved by the heating unit;a mass spectrometer detecting the gas component by performing mass analysis of the ions; anda gas channel, connecting the heating unit to the mass spectrometer, through which mixed gas of the gas component and carrier gas, carrying the gas component to the mass spectrometer, flows, wherein the gas channel comprises a branching channel opened to outside,the method comprising:a discharged flow rate adjusting process, adjusting a flow rate of the mixed gas discharged outside of the branching channel based on a detection signal received from the mass spectrometer so as to bring the detection signal within a given range;a sample holder cooling process, cooling the sample holder by bringing the sample holder into ...

Method and system for generating interference spectra for low detection limits using reactor

A gas analysis system and method with a spectrometer, such as a Fourier transform infrared spectrometer, utilizing a reactor, such as a catalytic reactor, for providing reference spectra.

System having a pre-separation unit

There is provided a system including a monitoring unit that analyzes, using a sensor, components of a first gas which may include first components and a pre-separation unit disposed upstream of the monitoring unit. The pre-separation unit includes: a first supply line that supplies the first gas to the monitoring unit; a second supply line that supplies a second gas, which includes components obtained by removing the first components from the first gas using a first separator, to the monitoring unit; and an automatic valve station that periodically switches between the first supply line and the second supply line to alternately supply the first gas and the second gas to the monitoring unit.

Large Scale Gas Electron Multiplier with Sealable Opening

A detector assembly includes a hollow body in which a printed circuit board, a resistive plate, a drilled board, a drift volume, and a cathode are disposed. A surface of the printed circuit board exposed to the resistive plate includes printed circuit lines for measuring first and second coordinates of a charge event. The hollow body can include a sealable opening to remove contaminants outgassed from one or more components of the detector assembly and to fill the hollow body with an operational gas. The sealable opening can be fluidly coupled to a gas and vacuum system to reduce the concentration of the outgassed contaminants. 1. A detector module comprising:a hollow body having an internal volume that retains a gas;{'sup': '−6', 'a sealable opening disposed on the hollow body, the sealable opening in fluid communication with the internal volume, wherein when the sealable opening is sealed, the sealable opening provides a vacuum-grade seal having a leak rate less than or equal to 1×10cc*atm/second; and'} a printed circuit board (PCB) having opposing first and second surfaces, the first surface exposed to the insulating substrate, the second face including printed circuit lines throughout an active area of each modular detector assembly;', 'a resistive plate disposed on and in direct physical contact with the second face of the PCB;', 'a drilled board disposed on the resistive plate; and', 'a cathode disposed above the drilled board, the cathode defining a drift volume between the cathode and the drilled board, the drilled board disposed between the drift volume and the resistive plate., 'a plurality of modular detector assemblies disposed in the hollow body, each modular detector assembly comprising2. The detector module of claim 1 , wherein the sealable opening comprises an exit pipe configured to be cold-welded shut.3. The detector module of claim 1 , wherein the sealable opening comprises a seal-off valve.4. The detector module of claim 1 , wherein the sealable ...

AUTOMATED SYSTEM FOR ONLINE DETECTION OF ORGANIC MOLECULAR IMPURITIES IN SEMICONDUCTOR GRADE CHEMICALS

An embodiment of an analysis system can include an initial multi-port valve, at least one intermediate multi-port valve, a further multi-port valve, and a time-of-flight mass spectrometer (TOF-MS). The initial multi-port valve can be configured to receive a sample. The at least one intermediate multi-port valve can be fluidly connected to the initial multi-port valve and configured to receive the sample from the initial multi-port valve. A given intermediate multi-port valve can have an ion-exchange column associated therewith. The given intermediate multi-port valve can be configured selectably to one of direct the sample through the ion-exchange column associated therewith (in a speciation mode) or bypass the ion-exchange column (in an infusion mode). The further multi-port valve can be fluidly connected with the at least one intermediate multi-port valve and configured to receive the sample from therefrom. The time-of-flight mass spectrometer (TOF-MS) can be fluidly connected to the further multi-port valve. 1. An analysis system , comprising:an initial multi-port valve configured to receive a sample;at least one intermediate multi-port valve fluidly connected to the initial multi-port valve and configured to receive the sample from the initial multi-port valve, a given intermediate multi-port valve having an ion-exchange column associated therewith, the given intermediate multi-port valve configured selectably to one of direct the sample through the ion-exchange column associated therewith or bypass the ion-exchange column, the sample directed through a chosen ion-exchange column as part of a speciation mode of operation to remove a matrix material from the sample, the sample directed to bypass any ion-exchange column as part of an infusion mode of operation;a further multi-port valve fluidly connected with the at least one intermediate multi-port valve and configured to receive the sample from the at least one intermediate multi-port valve; anda time-of-flight ...

ONLINE MASS SPECTROMETER FOR REAL-TIME DETECTION OF VOLATILE COMPONENTS FROM THE GAS AND LIQUID PHASE FOR PROCESS ANALYSIS

The present disclosure relates to a method for analysis by mass spectrometer of liquid and/or gaseous samples, and to an apparatus for carrying out said method. A mass spectrometer is used which has a first flow element for liquid samples and a second flow element for gaseous samples. 1. A method for analysis by mass spectrometer of substances present in liquid and gaseous samples , the method comprising:a) optional introduction of at least one substance of a liquid sample into a first flow element of an apparatus or at least one substance of a gaseous sample into a second flow element of the apparatus, wherein the first flow element is different from the second flow element, so that the at least one substance is present in the gaseous state, andb) analysis by mass spectrometer of the at least one substance that is present in step a), in the gaseous state.2. The method according to claim 1 , further comprising a step a1) that lies ahead of step b) claim 1 , the at least one substance present in the gaseous state in step a) is introduced into a third flow element of the apparatus claim 1 , wherein a pressure of 0.01 to 0.5 mbar is present in the third flow element.3. The method according to claim 2 , wherein in a step a2) that lies ahead of step b) claim 2 , the at least one substance present in the gaseous state in step a) is introduced into a fourth flow element of the apparatus claim 2 , wherein a pressure of 10mbar or less is present in the fourth flow element.4. The method according to claim 1 , wherein the analysis by mass spectrometer according to step b) comprises the following steps:i) ionization of the at least one substance present in the gaseous state,ii) acceleration of the at least one substance ionized in step i),iii) selection of the at least one substance accelerated in step ii), andiv) detection of the at least one substance selected in step iii).5. The method according to claim 3 , wherein at least one of the first claim 3 , second claim 3 , third ...

TRAP REPLACEMENT MECHANISM AND MICROPARTICLE COMPOSITION ANALYZING APPARATUS

In a microparticle composition analyzing apparatus, when a depressurized chamber is opened to atmospheric pressure in order to replace a trap, a certain amount of time is needed to vacuum out the entire depressurized chamber again and return the depressurized chamber to the reduced pressure state, and this causes an increase in the dead time of the measurement. Provided is a trap replacement mechanism including a rod that supports a trap for trapping microparticles and a connection portion that includes at least a portion of an auxiliary space connected to a depressurized space in which the trap is provided. The trap can be withdrawn from the depressurized space to the auxiliary space side and opened to atmospheric pressure while the depressurized space is kept in a depressurized state, by moving the rod. 2. The trap replacement mechanism according to claim 1 , whereinthe connection portion includes a bellows mechanism, andan internal space of the bellows mechanism also functions as the auxiliary space.3. The trap replacement mechanism according to claim 1 , whereinthe connection portion includes a coupling portion for connecting to a depressurized chamber forming the depressurized space, and at least a portion of the auxiliary space is formed inside the coupling portion.4. The trap replacement mechanism according to claim 1 , whereinthe rod is capable of adjusting an arrangement position of the trap within the depressurized space.5. The trap replacement mechanism according to claim 1 , whereinthe rod is capable of supporting and being separated from the trap within the depressurized space.6. The trap replacement mechanism according to claim 1 , comprising:an auxiliary pump that depressurizes the auxiliary space.7. The trap replacement mechanism according to claim 1 , comprising:a gate valve that switches between a connected state and an isolated state realized between the depressurized space and the auxiliary space, whereinthe gate valve switches from the connected ...

ION TRAP MASS SPECTROMETER USING COLD ELECTRON SOUCE

The present invention relates to an ion trap mass spectrometer using a cold electron source, in a production of a portable mass spectrometer, in which a microchannel plate (MCP) module is used, initial electrons are induced by injecting ultraviolet photons emitted from an ultraviolet diode to a front surface of the MCP module, electron beams amplified from the electrons are amplified using a channeltron electron multiplier (CEM), the amplified electron beams are accurately adjusted and injected into an ion trap, thus increasing the amplification rate, and since a quadrupole field is used as an ion filter which returns the initially injected electrons to the inside of an ion trap mass separator, the ionization rate increases. 1. An ion trap mass spectrometer using a cold electron source , which uses a device configured to acquire an ionization source using an microchannel plate (MCP) and a channeltron electron multiplier (CEM) , in which ultraviolet photons radiated from an inside of a mass spectrometer vacuum chamber in a high vacuum state induce initial electron emission , gaseous molecules are ionized through an electron beam obtained by amplifying the electrons , and ions are detected , the ion trap mass spectrometer comprising:an ultraviolet diode which emits ultraviolet rays to the inside of the mass spectrometer vacuum chamber;an MCP module which induces initial electron emission of ultraviolet photons emitted from the ultraviolet diode, amplifies the emitted electrons, and obtains an electron beam at a back plate;a CEM module which amplifies the electron beam emitted from the MCP module, and obtains an electron beam in quantity;an electron focusing lens which focuses the electron beam amplified through the CEM module;an ion trap mass separator which ionizes the gaseous sample molecules using the electron beam injected through the electron focusing lens, and captures the ionized gaseous sample molecules in a certain space;an ion filter which prevents a loss of ...

METHOD FOR PRODUCING GASEOUS AMMONIUM FOR ION-MOLECULE-REACTION MASS SPECTROMETRY

Method for obtaining gaseous ammonium (NH) from an ion source, the ion source comprising a first area () and a second area () in a fluidly conductive connection, comprising the steps of a) introducing Nand HO into the first area () and second area () of the ion source; b) applying an ionization method to the mixture of Nand HO in the first area (); c) applying at least one electric field or adjusting pressure conditions or a combination of applying at least one electric field and adjusting pressure conditions promoting flow of ions from the first area () to the second area () and inducing reactions of the ions in the second area (); d) conducting NH out of the ion source. Ion Molecule Reaction-Mass Spectrometry instrument implementing this method for producing NH and then conducting NH to the reaction region. 1. A method for ionizing a sample with gaseous ammonium , comprising:{'sub': '4', 'sup': '+', 'claim-text': [{'sub': '2', '(a1) introducing a controlled flow of Ninto the first area or second area of the ion source;'}, {'sub': 2', '2, '(a2) introducing a controlled flow of HOO into the first area or second area of the ion source;'}, {'sub': 2', '2, '(b) applying an ionization method to the mixture of Nand HO in the first area;'}, {'b': '2', '(c) applying at least one electric field or adjusting pressure conditions or a combination of applying at least one electric field and adjusting pressure conditions promoting flow of ions from the first area to the second area and inducing reactions of the ions in the second area ();'}, {'sub': '4', 'sup': '+', '(d) conducting NH out of the ion source; and'}], '(i) obtaining gaseous ammonium (NH) from an ion source, the ion source comprising a first area and a second area in a fluidly conductive connection, comprising the steps of(ii) ionizing the sample in a reaction chamber being connected with the ion source.2. The method according to claim 1 , wherein the first area is a first ionization chamber and the second area is a ...

MASS SPECTROMETRY DEVICE

A mass spectrometry device that can perform highly robust, highly sensitive, and low-noise analysis and addresses the problems of preventing reductions in ion transfer efficiency and of suppressing the introduction of noise components from droplets, etc. An ion source generates ions, a vacuum chamber is evacuated by an evacuation means and for analyzing the mass of ions, and an ion introduction electrode introduces ions into the vacuum chamber. The ion introduction electrode has an ion-source-side front-stage pore, a vacuum-chamber-side rear-stage pore, and an intermediate pressure chamber between the front-stage pore and the rear-stage pore, the cross-sectional area of an ion inlet of the intermediate pressure chamber is larger than the cross-sectional area of the front-stage pore, the position of the central axis of the front-stage pore and the position of the central axis of the rear-stage pore are eccentric, and the cross-sectional area of an ion outlet of the intermediate pressure chamber is smaller than the cross-sectional area of the ion inlet. 1. A mass spectrometry device comprising:an ion source for generating ions;a vacuum chamber that is evacuated by an evacuation means and for analyzing the mass of the ions; andan ion introduction electrode for introducing the ions into the vacuum chamber,wherein the ion introduction electrode comprises a front-stage pore on the ion source side, a rear-stage pore on the vacuum chamber side, and an intermediate pressure chamber located between the front-stage pore and the rear-stage pore,wherein a cross-sectional area of an ion inlet of the intermediate pressure chamber is larger than a cross-sectional area of the front-stage pore,wherein a central axis of the front-stage pore and a central axis of the rear-stage pore are eccentrically positioned, andwherein the cross-sectional area of an ion outlet of the intermediate pressure chamber is smaller than the cross-sectional area of the ion inlet of the intermediate pressure ...

TRANSFER TUBE CALIBRATION

Disclosed herein is a method comprising liberating analyte material from a sample and transferring the liberated analyte material towards an inlet of an ion analyser via a sampling or transfer tube (). The presence of the analyte material is detected at a first position by a detector (), and this detection may be used to determine a transit time for the analyte material through at least a part of said sampling or transfer tube (). The detector () may be disposed within the sampling or transfer tube (). 1. A method of analysis comprising:liberating analyte material from a sample;transferring said analyte material towards an inlet via a sampling or transfer tube and transferring said analyte material through said inlet to an ion analyser;detecting the presence of said analyte material at a first position; andanalysing said analyte material and/or ions derived from said analyte material at said ion analyser;the method further comprising:determining a transit time of said analyte material through at least a part of said sampling or transfer tube using said detection at said first position.2. A method as claimed in wherein the presence of said analyte material is detected at said first position within said sampling or transfer tube.3. A method as claimed in claim 1 , wherein the step of liberating analyte material from the sample comprises generating aerosol claim 1 , smoke or vapour from the sample.4. (canceled)5. A method as claimed in claim 1 , wherein said first position is at or near an entrance to said sampling or transfer tube.6. A method as claimed in claim 1 , wherein the transit time of said analyte material through the at least a part of said sampling or transfer tube is determined using said detection at said first position and a subsequent detection of said analyte material and/or of ions derived from said analyte material claim 1 , wherein said or a subsequent detection is performed by or at the ion analyser.7. A method as claimed in claim 1 , wherein the ...

REAL TIME MEASUREMENT TECHNIQUES COMBINING LIGHT SOURCES AND MASS SPECTROMETER

The present invention provides a mass spectrometer comprising a sample inlet, an ionization source, a mass analyzer, and an ion detector, wherein the ionization source comprises a photoionization detector lamp. The invention also provides mass spectrometers comprising two photoionization detector lamps. The use of a photoionization detector lamp can provide an increase in the signal of detected compounds as compared to the signal of detected compounds obtained using a comparable mass spectrometer with a conventional electron pumped beam lamp. 1. A mass spectrometer comprising a sample inlet , an ionization source , a mass analyzer , and an ion detector , wherein the ionization source comprises a photoionization detector lamp.2. The mass spectrometer of claim 1 , wherein the mass analyzer comprises a time of flight analyzer.3. The mass spectrometer of claim 1 , wherein the photoionization detector lamp emits vacuum ultraviolet radiation.4. The mass spectrometer of claim 1 , wherein the photoionization detector lamp is a krypton discharge lamp.5. The mass spectrometer of claim 1 , wherein the photoionization detector lamp has a photon energy of between about 10 and about 11 eV.6108. The mass spectrometer of claim 1 , wherein the photoionization detector lamp has a photon energy of about . eV7. The mass spectrometer of claim 1 , further comprising a MgFwindow through which radiation from the photoionization detector lamp passes.8. The mass spectrometer of claim 1 , wherein the photoionization detector lamp comprises a MgFwindow.9. The mass spectrometer of claim 1 , wherein the photoionization detector lamp is associated with the mass spectrometer by means of an o-ring.10. The mass spectrometer of claim 1 , wherein the detection sensitivity for a given compound is at least 5 times the detection sensitivity for said compound using a comparable mass spectrometer wherein the ion detector comprises an electron beam pumped argon lamp of the same wavelength and same photon ...

Mass Spectrometry Apparatus, Gas Chromatograph-Mass Spectrometry Apparatus, and Flashing Current Control Apparatus

In a mass spectrometry apparatus, an electric field is applied to an injected specimen to ionize the specimen, and mass spectrometry of the specimen is performed. In an emitter which ionizes the specimen, a flashing process to increase a temperature of the emitter is repeatedly performed at a short-time interval during an injection period of the specimen. A flashing current controller controls a flashing current value to be applied to the emitter to increase, in a long term, a flashing temperature which the emitter reaches in the flashing process.

Mass Spectrometry System and Emitter Current Control Method

Mass spectrometry for a specimen is repeatedly performed while stepwise changing a parameter (for example, a current value) of an emitter current. Based on a plurality of chromatograms generated by this process, an evaluation value table including a plurality of evaluation values is generated. An individual evaluation value shows a degree of tailing for individual peak included in each chromatogram. A parameter function is generated based on the evaluation value table. The parameter of the emitter current is controlled according to the parameter function. 1. A mass spectrometry system comprising:a mass spectrometry apparatus that includes an ion source which generates ions;a power supply that supplies an emitter current to an emitter of the ion source; andone or more processors, configured to:calculate an evaluation value for a peak shape based on a chromatogram generated based on an output signal of the mass spectrometry apparatus;determine a parameter, which defines the emitter current, based on the evaluation value; andcontrol the emitter current according to the parameter.2. The mass spectrometry system according to claim 1 , whereinthe one or more processors are further configured to:execute trial control to control the power supply so that a plurality of emitter currents following a plurality of provisional parameters having different magnitudes from each other are sequentially supplied to the ion source, wherein a plurality of chromatograms corresponding to the plurality of provisional parameters are generated by the trial control;calculate a plurality of evaluation values corresponding to the plurality of provisional parameters based on the plurality of chromatograms; anddetermine the parameter based on the plurality of evaluation values.3. The mass spectrometry system according to claim 2 , whereineach of the plurality of chromatograms includes a peak array including a plurality of peaks generated under a common provisional parameter, andthe one or more ...

A GC/MS ARRANGEMENT AND MASS SPECTROMETER

A GC/MS arrangement, comprising: a GC unit; an MS unit; a transfer line fluidly connecting the GC unit and the MS unit a carrier gas valve for selectively supplying carrier gas to the transfer line; at least one monitoring unit associated with the MS unit for monitoring at least one operational condition of the MS unit; and a controller connected to the at least one monitoring unit and carrier gas valve, configured to close the carrier gas valve when a predetermined operational event is detected by the at least one monitoring unit. 1. A gas chromatography(GM)/mass spectrometer (MS) arrangement , comprising:a GC unit;an MS unit including a vacuum pumping arrangement;a transfer line fluidly connecting the GC unit and the MS unita carrier gas valve for selectively supplying carrier gas to the transfer line;at least one monitoring unit connected to the vacuum pumping arrangement for monitoring the status of the vacuum pumping arrangement; anda controller connected to the at least one monitoring unit and carrier gas valve, configured to close the carrier gas valve when the at least one monitoring unit detects a substantial loss of an operational vacuum in the MS unit.2. A GC/MS arrangement according to claim 1 , wherein the carrier gas valve is a normally-closed solenoid valve.35-. (canceled)6. A GC/MS arrangement according to claim 1 , wherein the controller is configured to close the carrier gas valve when the at least one monitoring unit detects that the vacuum pumping arrangement substantially loses power.7. A GC/MS arrangement according to claim 1 , wherein the controller is configured to close the carrier gas valve when the at least one monitoring unit detects that the speed of at least one pump unit of the vacuum pumping arrangement drops below a predetermined threshold.8. A GC/MS arrangement according to claim 1 , wherein the at least one monitoring unit includes or is connected to a pressure sensor in fluid communication with a chamber of the MS unit.9. A GC/MS ...

TRANSFER LINE, GCMS ARRANGEMENT AND MOUNTING ASSEMBLY

A transfer line for a GCMS arrangement, the transfer line comprising: a transfer probe having a probe bore to receive a GC column; a sealing cap movably mounted at a first end of the transfer probe; and a resilient element arranged to bias the sealing cap away from the first end of the transfer probe. 1. A transfer line for a gas chromatography mass spectrometer (GCMS) arrangement , the transfer line comprising:a transfer probe having a probe bore to receive a gas chromatography (GC) column;a sealing cap movably mounted at a first end of the transfer probe; anda resilient element arranged to bias the sealing cap away from the first end of the transfer probe.2. A transfer line according to claim 1 , further comprising a sleeve received within the probe bore claim 1 , the sleeve having a sleeve bore to receive the GC column claim 1 , optionally wherein the sleeve comprises an outer tube and an inner tube claim 1 , the inner tube having an inner tube bore to receive the GC column claim 1 , optionally wherein the outer tube is comprised of copper and/or the inner tube is comprised of stainless steel.34-. (canceled)5. A transfer line according to claim 2 , wherein the first end of the sleeve is spaced axially inwardly from the first end of the transfer probe.6. A transfer line according to claim 1 , wherein the transfer probe comprises a tip at the first end claim 1 , the outer surface of the tip being substantially cylindrical.7. A transfer line according to claim 1 , wherein the sealing cap is generally cylindrical and arranged to receive at least a part of the first end of the transfer probe therein.8. A transfer line according to claim 1 , wherein the sealing cap comprises an axial sealing face and the sealing face is surrounded by a radial chamfer surface.9. (canceled)10. A transfer line according to claim 1 , wherein the sealing cap comprises a cap aperture for receiving the first end of the transfer probe with a sliding fit.11. (canceled)12. A transfer line ...

CAPILLARY MICROEXTRACTOR OF VOLATILES (CMV)

A capillary microextractor of volatiles (CMV) allows the sampling of diagnostic volatiles that can be an explosive, explosive taggant, drug, poison, decomposition products thereof, a mixture of chemicals comprising an odor signature determined from detector dog trials, or volatile organic compounds indicative of a disease or other medical condition. The CMV has a thermally stable housing with orifices to allow the contact of a gas that contains one or more diagnostic volatiles with an absorbent that extracts and concentrates the diagnostic volatiles. After sampling, the CMV with the absorbed diagnostic volatiles can be placed in an ionized gas beam and introduced into a mass spectrometer or placed in a thermal desorption unit (TDU), where, upon heating, the diagnostic volatiles are released to an inlet port of an analytical instrument. Analytical instruments that can be used include gas chromatographs and ion mobility spectrometers for separation and mass spectrometers for unambiguous identification of the diagnostic volatiles. 1. A capillary microextractor of volatiles (CMV) , comprising:a housing having at least two orifices; andan absorbent, where the absorbent is porous and/or partitioned, wherein a gas can diffuse through the housing orifices and contact the absorbent.2. The CMV of claim 1 , wherein the housing comprising a material that is thermally stable to at least 300° C.3. The CMV of claim 1 , wherein the housing is a glass tube.4. The CMV of claim 1 , wherein the absorbent comprises polydimethylsiloxane (PDMS).5. The CMV of claim 1 , wherein the absorbent comprises a film on a support.6. The CMV of claim 5 , wherein the support comprises a plurality of thermally stable fibers and the film is an amorphous material with a thermal stability of at least 200° C.7. The CMV of claim 6 , wherein the amorphous material has a glass transition temperature below −10° C.8. The CMV of claim 5 , wherein the absorbent comprises a film of a polydimethylsiloxane gel (PDMS ...

DIRECT SAMPLE INTRODUCTION DEVICE AND METHOD FOR COOLING SAMPLE INTRODUCTION PROBE

A direct sample introduction device includes: a pre-evacuating chamber that has an internal space extending in a first direction through which a sample introduction probe extends in the first direction; a first ventilation unit that is allowed to be opened and closed, with a first end thereof being connected to the pre-evacuating chamber; and a second ventilation unit a first end of which is connected to the pre-evacuating chamber and a second end of which is connected to a low pressure source. 1. A direct sample introduction device , comprising:a pre-evacuating chamber that has an internal space extending in a first direction through which a sample introduction probe extends in the first direction;a first ventilation unit that is allowed to be opened and closed, with a first end thereof being connected to the pre-evacuating chamber; anda second ventilation unit a first end of which is connected to the pre-evacuating chamber and a second end of which is connected to a low pressure source.2. The direct sample introduction device according to claim 1 , wherein:the first end of the first ventilation unit and the first end of the second ventilation unit are arranged at the pre-evacuating chamber at different positions to each other in the first direction.3. The direct sample introduction device according to claim 1 , further comprising:a temperature sensor that measures information related to temperature of the sample introduction probe in the pre-evacuating chamber.4. The direct sample introduction device according to claim 1 , further comprising:a control unit that controls an open/closed state of the first ventilation unit, or at least one of an open/closed state of the second ventilation unit and pressure of the low pressure source.5. The direct sample introduction device according to claim 1 , further comprising:a third ventilation unit that is allowed to be opened and closed, with a first end thereof being connected to the pre-evacuating chamber and a second end ...

SAMPLE QUANTITATION WITH A MINIATURE MASS SPECTROMETER

The invention generally relates to sample analysis with a miniature mass spectrometer. In certain embodiments, the invention provides methods that involve generating ions of a first analyte and ions of a second analyte. Those ions are transferred through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer in a manner in which the discontinuous sample introduction interface remains open during the transferring. The discontinuous sample introduction interface is closed and the ions are sequentially transferred to a second ion trap of the mass spectrometer where they are sequentially analyzed. 1. A method for analyzing a plurality of analytes , the method comprising:generating ions of a first analyte and ions of a second analyte;transferring the ions of the first and second analytes through a discontinuous sample introduction interface into a first ion trap of a mass spectrometer, wherein the discontinuous sample introduction interface remains open during the transferring;closing the discontinuous sample introduction interface;sequentially transferring the ions of the first and second analytes to a second ion trap of the mass spectrometer; andsequentially analyzing the ions of the first and second analytes in the second ion trap.2. The method according to claim 1 , wherein the first analyte is a sample and the second analyte is an internal standard.3. The method according to claim 1 , wherein transferring the ions of the first and second analytes through the discontinuous sample introduction interface into a first ion trap occurs simultaneously.4. The method according to claim 1 , wherein the first ion trap is a linear quadrupole ion trap.5. The method according to claim 1 , wherein the second ion trap is a rectilinear ion trap.67-. (canceled)8. The method according to claim 1 , wherein the first and second ions are transferred to the second ion trap within a single scan cycle.9. The method according to claim 1 , wherein analyzing ...

MASS SPECTROMETER INLET WITH REDUCED AVERAGE FLOW

An interface configured to transfer ions produced at or near atmospheric pressure conditions into a mass spectrometer for mass analysis is provided. The interface includes a first conduit including an inlet configured to receive a fluid containing the ions and an outlet configured to direct the fluid containing the ions into the mass spectrometer. The first conduit defines a first flow path extending from the inlet to the outlet. The interface includes a pump. The interface includes a second conduit. The second conduit includes an inlet. The second conduit defines a second flow path extending from a location between the inlet and the outlet of the first conduit to an outlet of the second conduit. The pump is configured to divert a portion of the fluid including the ions moving in the first flow path to the second flow path. 1. An interface configured to transfer ions produced in approximately atmospheric pressure conditions into a mass spectrometer for mass analysis comprising:a first conduit including an inlet configured to receive a fluid including the ions and an outlet configured to direct the fluid including the ions into the mass spectrometer, the first conduit defining a first flow path extending from the inlet to the outlet;a pump; anda second conduit including an inlet, the second conduit defining a second flow path extending from a location between the inlet and the outlet of the first conduit to an outlet of the second conduit;wherein the pump is configured to divert a portion of the fluid including the ions moving in the first flow path to the second flow path.2. The interface of claim 1 , comprising a valve located in the second flow path;wherein when the valve is in an open configuration, the valve allows a portion of the fluid including ions to be diverted from the first flow path to the second flow path by the pump;wherein when the valve is in a closed configuration, the valve does not allow a portion of the fluid including ions to be directed from ...

SAMPLE INJECTION DEVICE AND METHOD FOR SAMPLE COLLECTION AND SAMPLE THERMAL DESORPTION, AND TRACE DETECTION APPARATUS

The present invention discloses a sample injection device for sample collection and sample thermal desorption. The device comprises: a sample collection structure; a piston type adsorber having an adsorption cavity capable of being arranged to be in communication with the sample collection structure; a piston cylinder defining a piston chamber that is configured for accommodating the piston type adsorber and configured to be in communication with the adsorption cavity; a thermal desorption chamber that is configured to be in communication with the adsorption cavity and the piston chamber and is configured to thermally desorb the sample adsorbed in the adsorption cavity; and a pump that is configured to be in communication with the piston chamber via a conduit and is configured to pump a sample diffused in an ambient gas into the adsorption cavity through the sample collection structure, the adsorption cavity being configured to adsorb the sample collected by the sample collection structure; the piston type adsorber is configured to be movable between a sample collecting position where the adsorption cavity is located outside the thermal desorption chamber and in communication with the sample collection structure so as to adsorb the sample collected by the sample collection structure and a sample desorbing position where the adsorption cavity is located inside the thermal desorption chamber so that the adsorbed sample is thermally desorbed in the thermal desorption chamber. There are also provided a method of collecting and desorbing a sample by using the abovementioned device, and a trace detection apparatus. 1. A sample injection device for sample collection and sample thermal desorption , comprising:a sample collection structure;a piston type adsorber having an adsorption cavity that is capable of being arranged to be in communication with the sample collection structure;a piston cylinder defining a piston chamber that is configured for accommodating the piston ...

GAS CHROMATOGRAPH-ION MOBILITY SPECTROMETER SYSTEM

A GC-IMS system is disclosed in embodiments of the present invention. The system comprises a sample transfer device. The sample transfer device connects the gas chromatograph to the reaction region and, the sample from the gas chromatograph is transferred to the reaction region by the sample transfer device directly, instead of not through the ionization region. With the GC-IMS system, generation of sample molecular ion fragments can be avoided so that the spectrum is brevity and is easily identified; moreover, the application field of the GC-IMS system is extended to a range of analysis of organic macromolecule samples which have a high polarity, are difficult to volatilize, and are thermally instable. On the other hand, the GC-IMS system overcomes the defect of ion destruction due to neutralization reaction among positive and negative ions so as to evade the detection. 1. A GC-IMS system , comprising:a gas chromatograph,an IMS comprising: an ionization region for ionizing a gas to generate ions, and a reaction region which is adjacent to and different from the ionization region and is configured for combining the ions with a sample, anda sample transfer device which connects the gas chromatograph to the reaction region and by which the sample from the gas chromatograph is transferred to the reaction region directly, instead of through the ionization region or by which the sample from the gas chromatograph is transferred to the reaction region directly by bypassing the ionization region.2. The GC-IMS system of claim 1 , wherein:The IMS further comprises: an electrode disposed substantially between the ionization region and the reaction region and configured to generate an electric field for moving positive ions or negative ions of the ions generated in the ionization region into the reaction region.3. The GC-IMS system of claim 1 , wherein:The IMS comprises a dual-mode IMS comprising two reaction regions adjacent to the ionization region, andthe IMS further ...

Mass spectrometer

Provided is a mass spectrometer capable of easy exchange of a measurement sample and suppressing a carryover. The mass spectrometer includes a mass spectrometry section, an ion source the internal pressure of which is reduced by a differential pumping from the mass spectrometry section and the ion source ionizes the sample gas, a sample container in which the sample gas is generated by vaporizing the measurement sample, a thin pipe that introduces the sample gas generated in the sample container into the ion source, an elastic tube of openable and closable that connects the sample container and the thin pipe, a pair of weirs that closes or opens the elastic tube so as to sandwich the elastic tube, and a cartridge that integrates the sample container, the thin pipe, and the elastic tube, and is detachable in a lump from a main body of the mass spectrometer.

METHODS AND DEVICES FOR EVALUATING THE CONTENTS OF MATERIALS

Methods for determining the hardness and/or ductility of a material by compression of the material are provided as a first aspect of the invention. Typically, compression is performed on multiple sides of a geologic material sample in a contemporaneous manner. Devices and systems for performing such methods also are provided. These methods, devices, and systems can be combined with additional methods, devices, and systems of the invention that provide for the analysis of compounds contained in such samples, which can indicate the presence of valuable materials, such as petroleum-associated hydrocarbons. Alternatively, these additional methods, devices, and systems can also stand independently of the methods, devices, and systems for analyzing ductility and/or hardness of materials. 1. A method for analyzing the mechanical strength of a material from a geologic formation comprising:a. placing a sample of a material obtained from a geologic formation into a container which (i) isolates the sample and any gasses released from the sample from the environment; (ii) is adapted to be compressed without release of gasses contained in the container; and (iii) comprises a portion that is selectively accessible by a flow path component through which gasses in the container can be removed from the container for further analysis;b. subjecting the container to one or more compression forces, the one or more compression forces having sufficient strength to (a) compress the container without causing the release of any such gas from the container and (b) cause the sample in the container to be disrupted and thereby promote release of gas from the sample;c. determining the amount of compression of the container, the compression of the container being proportional to the strength of the sample, andd. assessing the mechanical strength of material from the geologic formation by evaluating the compression of the container.2. The method of claim 1 , wherein the one or more compression ...

BENCH-TOP TIME OF FLIGHT MASS SPECTROMETER

A mass spectrometer comprising: a vacuum chamber; and an ion inlet assembly for transmitting analyte ions into the vacuum chamber; wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly. 1. A mass spectrometer comprising:a vacuum chamber; andan ion inlet assembly for transmitting analyte ions into the vacuum chamber;wherein the spectrometer is configured to operate in a cooling mode in which it selectively controls one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.2. The spectrometer of claim 1 , comprising one or more temperature sensor for monitoring a temperature of the ion inlet assembly and/or an ion block in which the ion inlet assembly is mounted; wherein the spectrometer is configured to monitor the temperature sensed by the one or more temperature sensor during the cooling mode and to end the cooling mode when the sensed temperature has decreased to a predetermined temperature.3. The spectrometer of or claim 1 , comprising an ion source and an ion source heater for heating the ion source claim 1 , and/or an ion block in which the ion inlet assembly is mounted and an ion block heater for heating the ion block claim 1 , wherein the spectrometer is configured to switch off claim 1 , or reduce electrical power to claim 1 , the ion source heater and/or ion block heater during the cooling mode.4. The spectrometer of claim 3 , wherein the spectrometer is configured to end the cooling mode at a predetermined time after having switched off claim 3 , or reduced the electrical power to claim 3 , the ion source heater and/or ion block heater.5. The spectrometer of any preceding claim claim 3 , wherein the spectrometer is configured to end the cooling mode by switching off said one or more gas flow to the ion inlet assembly for actively cooling the ion inlet assembly.6. The spectrometer of any ...

SAMPLE INTRODUCTION DEVICE

A sample introduction device comprises a sampling unit, a gas suction pump, adsorption units, a piston cylinder and a desorption cylinder that comprises a desorption chamber, a carrier-gas inlet, a split/purge vent and an analyzer nozzle communicating with the desorption chamber. A heating film and a temperature sensor are provided on outer wall of the desorption cylinder. The piston cylinder above the desorption cylinder comprises two piston chambers, each of which is provided with the adsorption unit and in communication with the desorption chamber. The piston cylinder comprises a sample-gas inlet connected to the sampling unit and a gas-suction-pump orifice connected to the gas suction pump, each of which can communicate with both piston chambers. Each adsorption unit comprises an adsorption cylinder-like screen for holding adsorbents and a piston rod slidably mounted in the piston chamber. Each adsorption cylinder-like screen can simultaneously communicate with the sample-gas inlet and gas-suction-pump orifice. 1. A sample introduction device , comprising:a sampling unit,a gas suction pump,one or more adsorption units,a piston cylinder, and a desorption chamber,', 'a carrier-gas inlet, a split/purge vent and an analyzer nozzle, which are in communication with the desorption chamber, and', 'a heating film and a temperature sensor provided on an outer wall of the desorption cylinder;, 'a desorption cylinder, comprisingwherein the piston cylinder comprises two piston chambers, and each piston chamber is provided with a respective adsorption unit;wherein the piston cylinder is mounted above the desorption cylinder, and each of the two piston chambers is in communication with the desorption chamber;wherein the piston cylinder comprises a sample-gas inlet and a gas-suction-pump orifice, each of which is in communication with both of the piston chambers;wherein the sample-gas inlet is connected to the sampling unit, and the gas-suction-pump orifice is connected to the ...

Device for analyzing a sample gas comprising an ion source

A device for analyzing a sample gas comprises an ion source for generating primary ions, a reaction chamber to which the primary ions produced in the ion source and the sample gas to be analyzed can be supplied in order to form product ions by chemical ionization of components in the sample gas, and an analyzer/detector unit for determining different types of ions. A reaction space in the reaction chamber, within which the primary ions supplied to the reaction chamber and the product ions produced are guided and which extends between a first end facing the ion source and a second end facing the analyzer/detector unit, is surrounded by at least two electrodes which are in the form of helices which wind round a common axis with identical pitches and are offset with respect to one another in the direction of the axis. An AC voltage is applied to each of the electrodes.