Synchronised Variation of Source Conditions of an Atmospheric Pressure Chemical Ionisation Mass Spectrometer Coupled to a Gas Chromatograph to Improve Stability During Analysis

A mass spectrometer is disclosed comprising a gas chromatography separation device, an atmospheric pressure ionisation ion source and a control system arranged and adapted: (i) to operate the atmospheric pressure ionisation ion source at one or more first settings for a first period of time whilst one or more solvents elute from the gas chromatography separation device during a solvent front; and then (ii) to operate the atmospheric pressure ionisation ion source at one or more second different settings for a second subsequent period of time whilst one or more analytes elute from the gas chromatography separation device.

ION SOURCE WITH SURFACE COATING

A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. 1. A mass spectrometer comprising an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source , wherein said ion source comprises a first coating or surface provided on at least a portion of said ion source;wherein said first coating or surface comprises a metallic carbide coating or surface.2. A mass spectrometer as claimed in claim 1 , wherein said ion source comprises one or more ionisation chambers and said first coating or surface is provided on at least a portion of said one or more ionisation chambers.3. A mass spectrometer as claimed in claim 1 , wherein said ion source further comprises one or more repeller electrodes and said first coating or surface is provided on at least a portion of said one or more repeller electrodes.4. A mass spectrometer as claimed in claim 1 , wherein said ion source or said one or more ionisation chambers or said one or more repeller electrodes forming part of said ion source are made from a material selected from the group consisting of: (i) stainless steel; (ii) a steel alloy comprising ≧11.5% chromium wt. %; (iii) an austenitic stainless steel; (iv) a ferritic stainless steel; (v) an austenitic-ferritic or duplex steel; (vi) titanium; (vii) a titanium alloy; (viii) a nickel-base alloy; (ix) a nickel-chromium alloy; (x) a nickel-chromium alloy comprising ≧50.0% nickel wt. %; and (xi) INCONEL® 600 claim 1 , 625 claim 1 , 690 claim 1 , 702 claim 1 , 718 claim 1 , 939 or X750.5. A mass spectrometer as claimed in claim 1 , wherein said ion source or said one or more ionisation chambers or said one or more repeller electrodes forming part of said ion source comprise stainless steel or an alloy comprising:(i) 0-0.01 wt. % carbon; (ii) 0. ...

MASS SPECTROMETER SAMPLING CONE WITH COATING

A mass spectrometer includes an ion source, which includes a coating or surface formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal. 1. A mass spectrometer comprising a sampling cone or a cone-gas cone , wherein said sampling cone or said cone-gas cone comprise a first coating or surface provided on at least a portion of said sampling cone or said cone-gas cone , wherein said first coating or surface comprises a metallic carbide coating or surface.2. A mass spectrometer as claimed in claim 1 , wherein said sampling cone or said cone-gas cone is made from a material selected from the group consisting of: (i) stainless steel; (ii) a steel alloy comprising ≧11.5% chromium wt. %; (iii) an austenitic stainless steel; (iv) a ferritic stainless steel; (v) an austenitic-ferritic or duplex steel; (vi) titanium; (vii) a titanium alloy; (viii) a nickel-base alloy; (ix) a nickel-chromium alloy; (x) a nickel-chromium alloy comprising ≧50.0% nickel wt. %; and (xi) INCONEL® 600 claim 1 , 625 claim 1 , 690 claim 1 , 702 claim 1 , 718 claim 1 , 939 or X750.3. A mass spectrometer as claimed in claim 1 , wherein said sampling cone or said cone-gas cone comprises stainless steel or an alloy comprising:(i) 0-0.01 wt. % carbon; (ii) 0.01-0.02 wt. % carbon; (iii) 0.02-0.03 wt. % carbon; (iv) 0.03-0.04 wt. % carbon; (v) 0.04-0.05 wt. % carbon; (vi) 0.05-0.06 wt. % carbon; (vii) 0.06-0.07 wt. % carbon; (viii) 0.07-0.08 wt. % carbon; or (ix) >0.08 wt. % carbon.4. A mass spectrometer as claimed in claim 1 , wherein said sampling cone or said cone-gas cone comprises stainless steel or an alloy comprising:(i) 0-0.01 wt. % nitrogen; (ii) 0.01-0.02 wt. % nitrogen; (iii) 0.02-0.03 wt. % nitrogen; (iv) 0.03-0.04 wt. % nitrogen; (v) 0.04-0.05 wt. % nitrogen; (vi) 0.05-0.08 wt. % nitrogen; (vii) 0.06-0.07 wt. % nitrogen; or (viii) >0.07 wt. % nitrogen.5. A mass spectrometer as claimed in claim 1 , wherein said sampling cone or said cone-gas cone ...

Mass Spectrometer Sampling Cone With Coating

A sampling cone of a mass spectrometer is disclosed having a metallic boride coating such as titanium diboride.

Ion Source With Surface Coating

A mass spectrometer includes an Electron Impact (“EI”) or a Chemical Ionisation (“CI”) ion source, and the ion source includes a first coating or surface. The first coating or surface is formed of a metallic carbide, a metallic boride, a ceramic or DLC, or an ion-implanted transition metal.

SECONDARY ULTRASONIC NEBULISATION

A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample. 120-. (canceled)21. A mass or ion mobility spectrometer comprising: a liquid sample delivery capillary;', 'a sample receiving surface arranged for receiving a liquid sample from the capillary; and', 'an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample;, 'a secondary ultrasonic nebulisation device comprisinga vacuum chamber;an ion inlet orifice arranged between the sample receiving surface of the nebulisation device and the vacuum chamber, for receiving said charged droplets and/or ions;a structural component arranged in a flow path of the nebulised droplets and/or ion; anda heater configured to heat the structural component.22. The mass or ion mobility spectrometer of claim 21 , wherein the structural component is arranged in the vacuum chamber.23. The mass or ion mobility spectrometer of claim 22 , wherein the structural component is arranged in the flow path of the charged droplets and/or ions such that claim 22 , in use claim 22 , the droplets and/or ions impact onto the structural component.24. The mass or ion mobility spectrometer of claim 22 , wherein the structural component comprises a heated bead.25. The mass or ion mobility spectrometer of claim 22 , wherein the heater heats the structural component such that claim 22 , in use ...

ION SOURCE

A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions. 1. A method of ionizing a sample comprising:heating a sample so that analyte is released from the sample;producing charged particles downstream of the sample; andusing the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.2. The method of claim 1 , wherein the charged particles comprise charged droplets.3. The method of claim 2 , wherein the charged droplets comprise charged solvent droplets.4. The method of claim 2 , wherein the charged droplets comprise (i) water; (ii) formic acid and/or another organic acid; (iii) acetonitrile; and/or (iv) methanol.5. The method of claim 2 , wherein:producing charged particles downstream of the sample comprises causing droplets to impact upon an impactor target; andthe impactor target is located downstream of the sample.6. The method of claim 5 , wherein:the droplets are emitted from a sprayer outlet; andthe sprayer outlet is located downstream of the sample.7. The method of claim 6 , further comprising passing the analyte ions to an analytical instrument via an ion inlet; wherein:{'sub': '1', 'the sprayer outlet is located at a first distance xin a first direction from the ion inlet;'}{'sub': '2', 'the sample is located at a second distance xin the first direction from the ion inlet; and'}{'sub': 2', '1, 'the second distance xis larger than the first distance x.'}8. The method of claim 2 , wherein:producing charged particles downstream of the sample comprises emitting the charged droplets from a sprayer outlet; andthe sprayer outlet is located downstream of the sample.9. The method of claim 8 , further comprising passing the analyte ions to an ...

ION SOURCE

A method of ionisation is disclosed in which a sample is heated such that analyte is released from the sample. Analyte released from the sample is accumulated, and then the accumulated analyte is passed to an ionisation region where the analyte is ionised. 1. A method of ionisation comprising:heating a sample such that analyte is released from the sample;accumulating analyte released from the sample; and thenpassing the accumulated analyte to an ionisation region and ionising the analyte.2. A method as claimed in claim 1 , comprising:accumulating analyte released from the sample during a first period of time; andpassing the accumulated analyte to the ionisation region during a second period of time that follows the first period of time, wherein the second period of time is shorter than the first period of time.3. A method as claimed in claim 1 , comprising heating the sample and accumulating analyte released from the sample in one or more heating and/or accumulation regions.4. A method as claimed in claim 3 , wherein the method comprises:operating a first inlet valve and a first outlet valve in a closed state while accumulating the analyte; andpassing the accumulated analyte to the ionisation region by opening the first inlet valve and the first outlet valve.5. A method as claimed in claim 4 , wherein the method comprises:operating a bypass valve in an open state while accumulating the analyte; andoperating the bypass valve in a closed state while passing the accumulated analyte to the ionisation region.6. A method as claimed in claim 4 , wherein the method comprises:operating the first inlet valve in an open state and operating a second outlet valve in an open state before accumulating the analyte and/or after passing the accumulated analyte to the ionisation region.7. A method as claimed in claim 6 , wherein the method comprises:operating a second inlet valve in an open state, operating the second outlet valve in an open state, operating the first inlet valve in a ...

Ring Shaped Counter Electrode to Improve Beam Stability and Compound Sensitivity on a Ceramic Tile Type Microfluidic Device

An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge comprising a liquid chromatography separation column and an electrospray emitter . A counter electrode is arranged downstream of a tip of the electrospray emitter and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture of a mass spectrometer. 1. An interface for a mass spectrometer comprising:a microfluidic substrate, tile or cartridge comprising a liquid chromatography separation column and an electrospray emitter; anda counter electrode arranged downstream from a tip of said electrospray emitter and arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture of a mass spectrometer.2. An interface as claimed in claim 1 , wherein said counter electrode is arranged at a distance x mm downstream from said tip of said electrospray emitter claim 1 , wherein: (i) x is ≦10 mm claim 1 , ≦9 mm claim 1 , ≦8 mm claim 1 , ≦7 mm claim 1 , ≦6 mm claim 1 , ≦5 mm claim 1 , ≦4 mm claim 1 , ≦3 mm claim 1 , ≦2 mm or ≦1 mm; and/or (ii) x is >0 mm claim 1 , ≧0.5 mm claim 1 , ≧0.6 mm claim 1 , ≧0.7 mm claim 1 , ≧0.8 mm claim 1 , ≧0.9 mm or ≧1 mm.3. An interface as claimed in claim 1 , further comprising a voltage device arranged and adapted to apply a voltage to said electrospray emitter so as to maintain a potential difference between said electrospray emitter and said counter electrode claim 1 , wherein said potential difference between said electrospray emitter and said counter electrode results in the ionisation of droplets emitted from said electrospray emitter.4. An interface as claimed in claim 1 , wherein in use a liquid sample is passed through said liquid chromatography separation column at a flow rate <250 nL/min claim 1 , 250-500 nL/min claim 1 , 500-750 nL/min claim 1 , 750-1000 nL/min claim 1 , 1-2 μL/min claim 1 , 2-3 μL/min claim 1 , 3-4 μL/min claim 1 , 4-5 μL/min claim 1 , 5-6 ...

Secondary Ultrasonic Nebulisation

A secondary ultrasonic nebulisation device is disclosed comprising: a liquid sample delivery capillary; a sample receiving surface arranged for receiving a liquid sample from the capillary; and an ultrasonic transducer configured for oscillating the surface so as to nebulise the liquid sample received thereon, wherein the device is configured such that the oscillations of the surface by the ultrasonic transducer cause charged droplets and/or gas phase ions to be generated from the sample.

Piezo-Electric Vibration on an In-Source Surface Ionization Structure to Aid Secondary Droplet Reduction

An ion source is disclosed comprising a nebuliser and a target. The nebuliser is arranged and adapted to emit, in use, a stream of analyte droplets which are caused to impact upon the target and to ionise analyte to form a plurality of analyte ions. The target is vibrated by a piezo-electric vibration device to reduce the size of resultant secondary droplets.

In-Source Chemical Modification of Non Polar Analytes Using Atmospheric Pressure Chemical Ionisation Source

A method for analysing an aliphatic compound by mass spectrometry which comprises: (i) ionising an aliphatic compound in the presence of a heterocyclic modifier; and (ii) mass analysing the resulting ions to obtain mass spectrometric data.

Annular counter-electrode for improving beam stability and junction sensitivity on a ceramic tile-type microfluidic device

Schnittstelle für ein Massenspektrometer, welche Folgendes aufweist: ein Mikrofluidik-Substrat, eine Mikrofluidik-Kachel (1) oder eine Mikrofluidik-Patrone (1) mit einer Flüssigchromatographie-Trennsäule und einem Elektrospray-Emitter und eine Gegenelektrode (4), die stromabwärts einer Spitze des Elektrospray-Emitters angeordnet ist und dafür eingerichtet und ausgelegt ist, Ionen zu einer Atmosphärendruckschnittstelle oder Ioneneinlassöffnung (5) eines Massenspektrometers zu leiten, wobei die Gegenelektrode (4) stromaufwärts der Atmosphärendruckschnittstelle oder Ioneneinlassöffnung (5) des Massenspektrometers angeordnet ist, wobei die Gegenelektrode (4) in einem Abstand von x mm stromabwärts der Spitze des Elektrospray-Emitters angeordnet ist, wobei x≤ 5 mm und x > 0 mm ist. Interface for a mass spectrometer, comprising: a microfluidic substrate, a microfluidic tile (1) or a microfluidic cartridge (1) with a liquid chromatography separation column and an electrospray emitter and a counter-electrode (4) arranged downstream of a tip of the electrospray emitter and arranged and configured to direct ions to an atmospheric pressure interface or ion inlet port (5) of a mass spectrometer, the counter-electrode (4) being positioned upstream of the atmospheric pressure interface or ion inlet port (5 ) of the mass spectrometer, the counter-electrode (4) being arranged at a distance of x mm downstream of the tip of the electrospray emitter, where x≤5 mm and x>0 mm.

Ion source

A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.

A ring shaped counter electrode to improve beam stability and compound sensitivity on a ceramic tile type microfluidic device

An interface for a mass spectrometer comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2, and a counter electrode 4 arranged downstream of a tip of the electrospray emitter 2 and arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer. The electrode may be position less than or equal to 10mm downstream of the tip. The counter electrode maybe a ring or annular electrode, or may comprise one or more apertures. The counter electrode may be maintained at a higher or lower voltage or potential than the electrospray emitter. A mass spectrometer employing the interface and a method of liquid chromatography using the interface are also disclosed. An electrospray ionisation source for a mass spectrometer comprising an electrospray emitter, counter electrode with one or more apertures and a voltage device wherein the electrode is positioned downstream of the emitter.

Methods, mediums, and systems for identifying samples of interest by vector comparison

Exemplary embodiments provide methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.

Surface coating on sampling cone of mass spectrometer

Surface coating on sampling cone of mass spectrometer

A guide arrangement for a capillary holder

A guide arrangement for a capillary holder A guide arrangement for a capillary holder of the type having a housing and a capillary protruding from the housing, the guide arrangement comprising: a bracket; and a carriage translatably arranged with respect to the bracket, the carriage having a bed to receive the housing of the capillary holder.

An atmospheric pressure ionisation source

Surface coating on sampling cone of mass spectrometer

A sampling cone 3 of a mass spectrometer is disclosed having a Diamond Like Coating ("DLC").

Surface coating on sampling cone of mass spectrometer

A sampling cone (3) of a mass spectrometer is disclosed having a metallic boride coating such as titanium diboride.

Surface coating on ion source

An Electron Impact ("El") and a Chemical lonisation ("Cl") ion source are disclosed comprising a metallic boride coating or surface.

Surface coating on ion source

An ion source is disclosed comprising a Diamond Like Carbon surface.

Ion source

Surface coating on sampling cone of mass spectrometer

A sampling cone (3) of a mass spectrometer is disclosed having a metallic carbide coating such as titanium carbide.

Surface coating on sampling cone of mass spectrometer

A sampling cone (3) of a mass spectrometer is disclosed having a metallic carbide coating such as titanium carbide.

In-source chemical modification of non polar analytes using atmospheric pressure chemical ionisation source

A method for analyzing an aliphatic compound by mass spectrometry which comprises: (i) ionizing an aliphatic compound in the presence of a heterocyclic modifier; and (ii) mass analyzing the resulting ions to obtain mass spectrometric data.

An atmospheric pressure ionisation source

An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

An atmospheric pressure ionisation source

An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an aperture for receiving at least the distal end of a capillary into the ionisation chamber in use, the aperture having a capillary axis; a desolvation heater having a nozzle, for directing a stream of heated gas onto the distal end of the capillary in use, the nozzle having a nozzle axis; a corona discharge device including a corona pin having a corona axis, the corona pin for ionizing a sample in the ionisation chamber in use; and an inlet cone of a mass spectrometer arranged in the ionisation chamber, the inlet cone defining a cone entrance having a cone axis, wherein the cone axis is substantially coaxial with the corona axis and the capillary axis is substantially perpendicular to and intersects with the nozzle axis.

Sampling cone of mass spectrometer

A sampling cone (3) of a mass spectrometer is disclosed wherein the sampling cone (3) is made from a transition metal which has been subjected to ion implantation.

Surface coating on sampling cone of mass spectrometer

A sampling cone/cone-gas cone/extraction cone of a mass spectrometer is disclosed having a diamond like coating, DLC, thus offering a more robust and less reactive surface for the cone and affording the cone to require less extensive cleaning.

Sampling cone of mass spectrometer

A sampling cone 3 of a mass spectrometer is disclosed wherein the sampling cone 3 is made. from a transition metal (especially titanium) which has been subjected to ion implantation. Conventional cones, cone-gas cones and extraction cones can suffer from increased surface contamination following regular analysis of complex matrix extracts. An implanted transition metal material used for the cones offers a more robust and less reactive surface and therefore requires less extensive cleaning to maintain high performance.

An atmospheric pressure ionisation source

An atmospheric pressure ionisation source 1 comprising an ionisation chamber 3, comprising an inlet (Fig. 1A, 4) for receiving at least the distal end (5A) of a capillary (5) into the ionisation chamber 3 in use, a desolvation heater 10 including a heating element, for directing a stream of heated gas onto the distal end (5A) of the capillary (5) in use, a corona discharge device 20 arranged in the ionisation chamber 3 and a control system configured to operate the source in a selected mode. In an analytical mode, the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device 20. In a capillary priming mode the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device 20. The lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range

An atmospheric pressure ionisation source

An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an inlet for receiving at least the distal end of a capillary into the ionisation chamber in use; a desolvation heater including a heating element, for directing a stream of heated gas onto the distal end of the capillary in use; a corona discharge device arranged in the ionisation chamber; and a control system configured to operate the source in a selected one of: an analytical mode, in which the heating element is heated to a first temperature within a first temperature range, and in which a first current within a first current range is supplied to the corona discharge device; and a capillary priming mode, in which the heating element is heated to a second temperature within a second temperature range, and in which a second current within a second current range is supplied to the corona discharge device, wherein the lower limit of the second temperature range is higher than the lower limit of the first temperature range, and the second current range is higher than the first current range.

An atmospheric solids analysis source assembly

A nozzle for directing heated gas onto the distal end of a capillary arrangable adjacent the nozzle, the nozzle comprising: a housing defining a plenum for heated gas; and at outlet comprising at least one aperture fluidly connected to the plenum, the outlet configured to direct a curtain of the heated gas onto the distal end of a capillary in use, such that the curtain of heated gas is substantially aligned with the longitudinal axis of the capillary.

A guide arrangement for a capillary holder

A guide arrangement for a capillary holder A guide arrangement for a capillary holder of the type having a housing and a capillary protruding from the housing, the guide arrangement comprising: a bracket; and a carriage translatably arranged with respect to the bracket, the carriage having a bed to receive the housing of the capillary holder.

Secondary ultrasonic nebulisation

A secondary ultrasonic nebulisation device comprises a liquid sample delivery capillary 2 for receiving a liquid sample (which may be from a liquid chromatography separation device), a sample receiving surface 11 for receiving the liquid sample from the capillary, and an ultrasonic transducer 4. The ultrasonic transducer oscillates the surface so as to nebulise the liquid sample 13 and to generate charged droplets or gas phase ions from the sample. A heater is provided for heating a structural component arranged in a flow path of the nebulized droplets or ions e.g. so that the droplets impact onto the heated component. The heated component may be arranged in a vacuum chamber downstream of an ion inlet orifice. The liquid sample may form a liquid junction between the end of the capillary and the sample receiving surface. The charged droplets or gas phase ions may be analysed in a mass or ion mobility spectrometer.

Methods, mediums, and systems for identifying samples of interest by vector comparison

Methods, mediums, and systems for comparing a sample of interest to a library of known compounds to quickly determine how similar the sample is to the compounds in the library. Peaks of interest in the sample data are compared to corresponding peaks in the library compound data. These peaks may be represented as vectors, and an angle between the sample vector and the library vector may be used as a similarity metric. In some embodiments, a cosine similarity may be calculated for the vectors. If the similarity score for a given library compound/sample pair exceed a threshold, then the system determines that the library compound and the sample are similar and takes appropriate action. Various parameters associated with the comparison can be adjusted in order to improve the quality of the results and/or the efficiency of the process.

An atmospheric solids analysis source assembly

A nozzle for directing heated gas onto the distal end of a capillary arrangable adjacent the nozzle, the nozzle comprising: a housing defining a plenum for heated gas; and at outlet comprising at least one aperture fluidly connected to the plenum, the outlet configured to direct a curtain of the heated gas onto the distal end of a capillary in use, such that the curtain of heated gas is substantially aligned with the longitudinal axis of the capillary.

An atmospheric solids analysis source assembly

A nozzle for directing heated gas onto the distal end of a capillary arrangable adjacent the nozzle, the nozzle comprising: a housing defining a plenum for heated gas; and at outlet comprising at least one aperture fluidly connected to the plenum, the outlet configured to direct a curtain of the heated gas onto the distal end of a capillary in use, such that the curtain of heated gas is substantially aligned with the longitudinal axis of the capillary.

Synchronised variation of source conditions of an atmospheric pressure chemical ionisation mass spectrometer coupled to a gas chromatograph

Ion source

Ring shaped counter electrode to improve beam stability and compound sensitivity on a ceramic tile type microfluidic device

An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2 . A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer.