Osteoarthritis treatment and device

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.

Osteoarthritis treatment and device

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.

Endovascular aneurysm repair system

Method and apparatus for implanting radially expandable prostheses in the body lumens rely on tacking or anchoring of the prostheses with separately introduced fasteners. The prostheses may be self-expanding or balloon expandable. After initial placement, a fastener applier system is introduced within the expanded prostheses to deploy a plurality of fasteners at least one prosthesis end, usually as each end of the prosthesis. The fasteners are usually helical fasteners which are delivered from a helical track in the fastener applier by rotation with a rotator wire. The fasteners will be applied singly, typically in circumferentially spaced-apart patterns about the interior of each end of the prosthesis.

Bicyclic compound and use thereof for medical purposes

Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

Polyaxial fastener systems and methods

Treating fractures using one or both of an implant, such as an intramedullary nail, and a fastening assembly, such as a lag screw and compression screw assembly. The implant in some implementations has a proximal section with a transverse aperture having a non-circular cross-section that may be shaped to selectively constrain the fastening assembly within the transverse aperture. Two or more components of the fastening assembly may be received to slide, in a controlled way, in the transverse aperture of the implant, and to cooperate to resist a force moment applied thereto.

Three-dimensional annuloplasty ring

An annuloplasty ring having a three-dimensional discontinuous form generally arranged about an axis with two free ends that are axially offset. The ring is particularly suited for repair of the tricuspid valve, and more closely conforms to the annulus shape. The ring is more flexible in bending about radially extending axes than about the central axis. The ring may have an inner structural support covered by a pliable sleeve and/or a fabric tube. The structural support may have a varying cross-section, such as a C-shaped cross-section in a mid-section between two free ends and a rectangular cross-section at the free ends.

Marking template for installing a custom replacement device for resurfacing a femur and associated installation method

A replacement device for resurfacing a joint surface of a femur and a method of making and installing such a device is provided. The custom replacement device is designed to substantially fit the trochlear groove surface, of an individual femur, thereby creating a “customized” replacement device for that individual femur and maintaining the original kinematics of the joint. The top surface is designed so as to maintain centrally directed tracking of the patella perpendicular to the plane established by the distal end of the femoral condyles and aligned with the center of the femoral head.

Articular cartilage implants

Implant devices having an articular end for repair of articular cartilage defects are provided. The articular end has an oval perimeter, a convex upper face, and a concave lower face. The convex upper face has a first circular pitch radius and a first circular roll radius. At least a portion of the concave lower face has a spherical radius, the convex upper face blending into a rim, wherein at least a first and second portion of the rim extends at least a first distance along a vertical axis and a third and fourth portion of the rim tapers inward along the vertical axis, the rim blending into the concave lower face. The articular cartilage implant devices further include a stem extending from the concave lower face away from the convex upper face along the vertical axis. The stem has a plurality of oval shaped perimeters along the vertical axis.

Method for making grooves on a luminal surface of an intravascular stent

The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein.

Devices For Introduction Into A Body Via A Substantially Straight Conduit To Form A Predefined Curved Configuration, And Methods Employing Such Devices

A device for introduction into a body in a straight configuration and assuming within the body a predefined curved configuration, includes an elongated element formed from a number of segments interconnected so as to form effective hinges therebetween. When the elongated element is confined to a straight state, the effective hinges transfer compressive forces from each segment to the next so that the elongated element can be pushed to advance it through a conduit. When the elongated element is not confined to a straight state, the effective hinges allow deflection of each segment relative to adjacent segments until abutment surfaces of the segments come into abutment, thereby defining a fully flexed state of the elongated element with a predefined curved configuration. The device can be produced with a wide range of two-dimensional and three-dimensional curved forms, and has both medical and non-medical applications.

Methods of implanting minimally-invasive prosthetic heart valves

Expandable prosthetic heart valves for minimally invasive valve replacement are disclosed. In one preferred embodiment, an expandable prosthetic heart valve includes a support stent comprising an expandable tubular base along an inflow end and three upstanding commissure posts along an outflow end. The three commissure posts are spaced at 120 degree intervals with gaps therebetween. The prosthetic heart valve further includes a tubular flexible member having a prosthetic section and a fabric section. The prosthetic section is connected to the three commissure posts and defines three leaflets, preferably formed of pericardial tissue. The fabric section is sutured to the expandable tubular base. The tubular base may be formed with a shape memory material and is sized for deployment with an annulus of a native aortic valve. After deployment, the three commissure posts support the leaflets above the tubular base for replacing the function of the native aortic valve. In one variation, flanges may be provided on the support stent for improving attachment of the support stent to the host tissue.

Methods of building a body portion

An improved method of implanting cells in the body of a patient includes positioning viable cells on a support structure. One or more blood vessels may be connected with the support structure to provide a flow of blood through the support structure. A support structure may be positioned at any desired location in a patient's body. The support structure may be configured to replace an entire organ or a portion of an organ. An organ or portion of an organ may be removed from a body cells and/or other tissue is removed to leave a collagen matrix support structure having a configuration corresponding to the configuration of the organ or portion of an organ. Alternatively, a synthetic support structure may be formed. The synthetic support structure may have a configuration corresponding to a configuration of an entire organ or only a portion of an organ.

Nano-skeletal catalyst

A method of producing a catalyst material with nano-scale structure, the method comprising: introducing a starting powder into a nano-powder production reactor, the starting powder comprising a catalyst material; the nano-powder production reactor nano-sizing the starting powder, thereby producing a nano-powder from the starting powder, the nano-powder comprising a plurality of nano-particles, each nano-particle comprising the catalyst material; and forming a catalyst precursor material from the nano-powder, wherein the catalyst precursor material is a densified bulk porous structure comprising the catalyst material, the catalyst material having a nano-scale structure.

Methods for Making an Encapsulated Stent

A method for making an encapsulated stent includes providing first and second ePTFE layers and a stent positioned therebetween. The first ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented perpendicular to the longitudinal axis. The second ePTFE layer may be unsintered and have a node-fibril microstructure in which the fibrils are oriented parallel to the longitudinal axis. The method includes joining the first ePTFE layer to the second ePTFE layer through openings in a wall of the stent.

Instrumentation And Methods For Use In Implanting A Cervical Disc Replacement Device

Instrumentation for implanting a cervical disc replacement device includes cervical disc replacement trials for determining the appropriate size of replacement device to be implanted, an insertion plate for maintaining the elements of the replacement device in fixed relation to one another for simultaneous manipulation, an insertion handle for attachment to the insertion plate for manipulation of the elements, an insertion pusher for releasing the insertion handle from the insertion plate, a drill guide that cooperates with the insertion plate to guide the drilling of tap holes for bone screws to be placed through bone screw holes in the flanges of the replacement device, clips that are applied to the flanges after placement of the bone screws to resist screw backout, and a clip applicator for applying the clips to the flanges.

PRODUCING A THREE-DIMENSIONAL MODEL OF AN IMPLANT

Determining a shape of a medical device to be implanted into a subject produces an image including a defective portion and a non-defective portion of a surface of a tissue of interest included in the subject. The tissue of interest is segmented within the image. A template, representing a normative shape of an external anatomical surface of the tissue of interest, is superimposed to span the defective portion. An external shape of an implant, is determined as a function of respective shapes of the defective portion as seen in the template, for repairing the defective portion. 2. The method as set forth in claim 1 , wherein the x-ray image data comprises a plurality of image slices of the target tissue.3. The method of claim 1 , wherein the medical device is an implant to be implanted in a subject.4. The method of claim 1 , further comprising generating the x-ray image data of the target tissue.5. The method of claim 4 , further comprising fabricating the the medical device at least partially based on the shape.6. The method of claim 1 , further comprising fabricating the medical device at least partially based on the shape.7. The method of claim 1 , wherein deforming the three-dimensional template to match the identified one or more locations to determine the shape of the medical device comprises determining the shape of the medical device at least partially based on the deformed template that spans the defective portion.8. The method of claim 1 , wherein the one or more locations are on an external surface of the non-defective portion of the computer-based three-dimensional representation of the target tissue. This application is a continuation of U.S. patent application Ser. No. 15/075,498, filed Mar. 21, 2016, which is a continuation of U.S. patent application Ser. No. 14/277,275, filed May 14, 2014, which is a continuation of U.S. patent application Ser. No. 12/720,518, filed on Mar. 9, 2010, which is a continuation-in-part of U.S. patent application Ser. No. 10 ...

Methods and systems for producing an implant

A computer implemented method for determining the 3-dimensional shape of an implant to be implanted into a subject includes obtaining a computer readable image including a defective portion and a non-defective portion of tissue in the subject, superimposing on the image a shape to span the defective portion, and determining the 3-dimensional shape of the implant based on the shape that spans the defective portion.

SYSTEM AND METHOD FOR TREATING AN OCULAR DISORDER

Surgical methods and related medical devices for treating ocular disorders are disclosed. Some methods relate to delivering an implant within an eye, and involve providing an elongate guide device, such as, a flexible guide member or a guide wire. A distal end of the guide device can be advanced into an anterior chamber of an eye, or through at least a portion of a site of resistance along a physiologic outflow pathway of the eye, or from an anterior chamber of the eye to a location proximate a physiologic outflow pathway of the eye. The implant is advanced along the guide device toward the guide device distal end, and is positioned to conduct aqueous humor between the anterior chamber and the physiologic outflow pathway. 1. (canceled)2. A method of treating glaucoma comprising:forming an incision in a cornea of an eye;inserting a delivery applicator through the incision in the cornea and across at least a portion of an anterior chamber of the eye in an ab interno manner under gonioscopic guidance, the delivery applicator comprising an elongate member having a distal end portion configured to retain an implant therein, the distal end portion comprising a cutting member configured to penetrate a trabecular meshwork of the eye for receipt of the implant in Schlemm's canal;penetrating the trabecular meshwork using the cutting member of the delivery applicator;guiding the implant into Schlemm's canal such that a distal section of the implant extends along a length of Schlemm's canal and such that a proximal end of the implant is positioned in the anterior chamber; andremoving the delivery applicator from the eye,wherein the implant comprises flexible material that is at curved along its distal section,wherein the implant is sized and shaped so as to slide in place in Schlemm's canal without undue suturing, andwherein the implant has at least one opening positioned along its distal section.3. The method of claim 2 , wherein the incision is a self-sealing incision.4. The ...

Heart valve prosthesis and methods of manufacture and use

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

PERCUTANEOUSLY IMPLANTABLE REPLACEMENT HEART VALVE DEVICE AND METHOD OF MAKING SAME

A replacement heart valve device including a stent member that is to be compressible and expandable, and a dry valve directly sutured to the stent member. The dry valve includes two to four leaflets made of a treated pericardium tissue that has been gas sterilized. 1. A replacement heart valve device , comprising:a stent member, the stent member configured to be compressible and expandable; anda dry valve directly sutured to the stent member, wherein the dry valve includes two to four leaflets made of a treated pericardium tissue, and wherein the treated pericardium tissue has been gas sterilized.2. The replacement heart valve device of claim 1 , wherein the stent member is self-expanding.3. The replacement heart valve device of claim 1 , wherein the stent member is balloon expandable.4. The replacement heart valve device of claim 1 , wherein the stent member is made of nitinol.5. The replacement heart valve device of claim 1 , wherein the stent member is made of stainless steel.6. The replacement heart valve device of claim 1 , wherein the stent member includes a tubular structure that flares at both ends in a trumpet-like configuration.7. The replacement heart valve device of claim 1 , wherein the treated pericardium tissue comprises treated mammalian pericardium tissue.8. The replacement heart valve device of claim 7 , wherein the treated pericardium tissue has been treated with glutaraldehyde.9. The replacement heart valve device of claim 8 , wherein a pericardium tissue forming the dry valve has been subjected to light and mechanical compression to decrease the molecular distance of collagen fibers.10. An assembly for percutaneous and transluminal delivery of a medical implant claim 8 , comprising:a delivery and implantation system including a flexible catheter; and a stent member, the stent member configured to be compressible and expandable; and', 'a dry valve directly sutured to the stent member, wherein the dry valve includes two to four leaflets made of ...

Instrumentation And Methods For Use In Implanting A Cervical Disc Replacement Device

Instrumentation for implanting a cervical disc replacement device includes cervical disc replacement trials for determining the appropriate size of replacement device to be implanted, an insertion plate for maintaining the elements of the replacement device in fixed relation to one another for simultaneous manipulation, an insertion handle for attachment to the insertion plate for manipulation of the elements, an insertion pusher for releasing the insertion handle from the insertion plate, a drill guide that cooperates with the insertion plate to guide the drilling of tap holes for bone screws to be placed through bone screw holes in the flanges of the replacement device, clips that are applied to the flanges after placement of the bone screws to resist screw backout, and a clip applicator for applying the clips to the flanges. 1a first element having an upper surface for seating against a lower end plate surface of a superior vertebral body and a lower articulating surface, which lower articulating surface includes a saddle surface that is defined by a concave arc having a constant radius of curvature A about an axis perpendicular to an anterior-posterior plane of a spinal column, and a convex arc having a constant radius of curvature B about an axis perpendicular to a lateral plane of the spinal column; anda second element having a lower surface for seating against an upper endplate surface of an inferior vertebral body and an upper articulation surface, which upper articulation surface includes a saddle surface that is defined by a convex arc having a constant radius of curvature C about the axis perpendicular to the anterior-posterior plane of the spinal column and a concave arc having a constant radius of curvature D about the axis perpendicular to the lateral plane of the spinal column;wherein the saddle surface of the first element and the saddle surface of the second element are nestable with one another and articulatable against one another in flexion/ ...

Prosthetic iris preparation method

A method and system of producing a digitally printed iris structure for an artificial eye by using suitable digital graphics software, the appearance of a dilating pupil/collarette is created within the combined center portion/inner ring area of a prosthetic eye—in that a pupil appears to dilate from a small diameter in bright light to a comparatively large diameter in dimmer or darker light. The process of creating such effect is a unique extension of the knowledge that certain colors and pigments in bright light are most apparent, and in dark light tend to appear grey to black.

Bicyclic compound and use thereof for medical purposes

Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

OSTEOARTHRITIS TREATMENT AND DEVICE

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container. 1. (canceled)2. A method of delivering an implant to a targeted treatment area in a subchondral region of a first bone adjacent a knee joint for treating a bone marrow lesion identified in the subchondral region , the method comprising:identifying a bone marrow lesion (BML) in a subchondral region of a first bone adjacent a knee joint through use of magnetic resonance imaging (MM) of the knee joint, the subchondral region of the first bone occurring under an articular surface of the first bone; anddelivering a solid structural implant to a targeted treatment area in the subchondral region of the first bone, wherein the targeted treatment area includes an area in the subchondral region where the bone marrow lesion was identified and/or an area in the subchondral region that is up to 1 cm from where the bone marrow lesion was identified, wherein the solid structural implant is resorbable, and wherein the solid structural implant is delivered to the targeted treatment area along a subchondral delivery path that is formed in the first bone without creating a void in the targeted treatment area that opens into the overlying articular cartilage of the first ...

Method of Making Recessed Features on Inner Surface of Tubular Structure by Thermal Ablation

The invention relates to methods and apparatus for manufacturing intravascular stents wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein.

Methods of implanting minimally-invasive prosthetic heart valves

Expandable prosthetic heart valves for minimally invasive valve replacement are disclosed. In one preferred embodiment, an expandable prosthetic heart valve includes a support stent comprising an expandable tubular base along an inflow end and three upstanding commissure posts along an outflow end. The three commissure posts are spaced at 120 degree intervals with gaps therebetween. The prosthetic heart valve further includes a tubular flexible member having a prosthetic section and a fabric section. The prosthetic section is connected to the three commissure posts and defines three leaflets, preferably formed of pericardial tissue. The fabric section is sutured to the expandable tubular base. The tubular base may be formed with a shape memory material and is sized for deployment with an annulus of a native aortic valve. After deployment, the three commissure posts support the leaflets above the tubular base for replacing the function of the native aortic valve. In one variation, flanges may be provided on the support stent for improving attachment of the support stent to the host tissue.

Osteoarthritis treatment and device

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container.

Multiple-layer immune barrier for donor cells

A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.

Instrumentation and methods for use in implanting a cervical disc replacement device

Instrumentation for implanting a cervical disc replacement device includes cervical disc replacement trials for determining the appropriate size of replacement device to be implanted, an insertion plate for maintaining the elements of the replacement device in fixed relation to one another for simultaneous manipulation, an insertion handle for attachment to the insertion plate for manipulation of the elements, an insertion pusher for releasing the insertion handle from the insertion plate, a drill guide that cooperates with the insertion plate to guide the drilling of tap holes for bone screws to be placed through bone screw holes in the flanges of the replacement device, clips that are applied to the flanges after placement of the bone screws to resist screw backout, and a clip applicator for applying the clips to the flanges.

MEDICAL DEVICE SUITABLE FOR LOCATION IN A BODY LUMEN

A medical device suitable for location in a body lumen is movable between a first loaded configuration and a second loaded configuration. The device has an unloaded configuration which is intermediate the first loaded configuration and the second loaded configuration. The device can be a stent for deployment in a blood vessel. 1. A method of stenting a body lumen , comprising:deploying and expanding a stent in a body lumen, the stent having a diameter, the body lumen being deformable between an unloaded state and a loaded state;wherein the stent is one which, after deployment and expansion, is deformable between a first loaded configuration and a second loaded configuration and has an unloaded configuration intermediate the first loaded configuration and the second loaded configuration;wherein in said unloaded and second loaded configurations at least part of the longitudinal axis of the stent is substantially helically shaped and has an amplitude and wherein in the second loaded configuration the amplitude of the helical longitudinal axis divided by the diameter of the stent is greater than in the unloaded configuration;and wherein the deploying comprises deploying the stent in the body lumen so that when the body lumen is in the unloaded state the stent is in the first loaded configuration, and when the body lumen is in the loaded state the stent is in the second loaded configuration.2. A method as claimed in claim 1 , wherein the pitch of the helical longitudinal axis is less in the second loaded configuration than in the unloaded configuration.3. A method as claimed in claim 1 , wherein in the first loaded configuration at least part of the longitudinal axis of the stent is substantially helically shaped and the amplitude of the helical longitudinal axis divided by the diameter of the stent is less than in the unloaded configuration.4. A method as claimed in claim 3 , wherein the pitch of the helical longitudinal axis is greater in the first loaded configuration ...

Method of deploying a percutaneous replacement heart valve

A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

Fluid recirculation system for use in vapor phase particle production system

A method of and system for recirculating a fluid in a particle production system. A reactor produces a reactive particle-gas mixture. A quench chamber mixes a conditioning fluid with the reactive particle-gas mixture, producing a cooled particle-gas mixture that comprises a plurality of precursor material particles and an output fluid. A filter element filters the output fluid, producing a filtered output. A temperature control module controls the temperature of the filtered output, producing a temperature-controlled, filtered output. A content ratio control module modulates the content of the temperature-controlled, filtered output, thereby producing a content-controlled, temperature-controlled, filtered output. A channeling element supplies the content-controlled, temperature-controlled, filtered output to the quench chamber, wherein the content-controlled, filtered output is provided to the quench chamber as the conditioning fluid to be used in cooling the reactive particle-gas mixture.

PRODUCING A THREE-DIMENSIONAL MODEL OF AN IMPLANT

Determining a shape of a medical device to be implanted into a subject produces an image including a defective portion and a non-defective portion of a surface of a tissue of interest included in the subject. The tissue of interest is segmented within the image. A template, representing a normative shape of an external anatomical surface of the tissue of interest, is superimposed to span the defective portion. An external shape of an implant, is determined as a function of respective shapes of the defective portion as seen in the template, for repairing the defective portion. 1. A three-dimensional medical device comprising:an outer surface having a shape corresponding to a deformed three-dimensional template,wherein the deformed three-dimensional template is formed by deforming a three-dimensional template representing a normative shape of an anatomical surface of a target tissue, wherein the target tissue comprises a portion with a defect and a portion without a defect,wherein the three-dimensional template representing a normative shape of an anatomical surface of a target tissue is deformed to a computer-generated three-dimensional representation rendered from the image data of the target tissue.2. The three-dimensional medical device of claim 1 , wherein the portion of the target tissue with the defect is a missing segment of bony structure.3. The three-dimensional medical device of claim 2 , wherein the outer surface fits within the missing segment of bony structure.4. The three-dimensional medical device of claim 2 , wherein the outer surface fits precisely within the missing segment of bony structure.5. The three-dimensional medical device of claim 1 , wherein at least a portion of the target tissue with the defect comprises soft tissue.6. The three-dimensional medical device of claim 1 , wherein the outer surface comprises three-dimensional printed material.7. A three-dimensional model for use in fabricating an implantable medical device claim 1 , the model ...

CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device. 1. A coring device comprising:a coring cylinder configured for advancing through a tissue wall to define an aperture in the tissue wall by removing a tissue core from the tissue wall, the coring cylinder defining a coring bore extending along a longitudinal axis of the coring device and configured for receiving the tissue core therein; anda retrieval device configured for piercing the tissue wall, the retrieval device comprising a corkscrew configured for retaining the tissue core.2. The coring device of claim 1 , wherein the coring cylinder and the retrieval device are movable relative to one another in a direction of the longitudinal axis of the coring device.3. The coring device of claim 1 , wherein a longitudinal axis of the coring cylinder and a longitudinal axis of the retrieval device are coaxial with one another.4. The coring device of claim 3 , wherein the longitudinal axis of the coring cylinder and the longitudinal axis of the retrieval device are coaxial with the longitudinal axis of the coring device.5. The coring device of claim 1 , wherein the retrieval device is configured for piercing the tissue wall prior to removal of the tissue core from the tissue wall.6. The coring device of claim 1 , further comprising a handle engaged with the coring cylinder.7. ...

Modular bioresorbable or biomedical, biologically active supramolecular materials

The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or biomedical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.

NESTED EXPANDABLE SLEEVE IMPLANT

An expandable implant for treating bone preferably in a minimally invasive manner includes a preferably cylindrical core element extending along a longitudinal axis and preferably a plurality of nestable, expandable sleeves extending along a longitudinal axis for placement radially about the core element. The plurality of nestable sleeves are sequentially insertable over the core element in such a manner that a first nestable sleeve is inserted over the core element and each subsequently inserted nestable sleeve is received between the core element and the previously inserted nestable sleeve such that the insertion of each additional sleeve causes each previously inserted sleeve to outwardly expand. 1. A method of inserting an implant into a target location in a spinal column , the method comprising steps of:attaching a shaft of an insertion instrument to a core having a core body that defines a proximal end and a distal end spaced from the proximal end along a distal direction;inserting the core and a first sleeve in the distal direction through an access path to the target location such that an interior surface of the first sleeve that defines an internal bore of the first sleeve faces the core; andadvancing a second sleeve in the distal direction between the first sleeve and the core such that an exterior surface of the second sleeve faces the interior surface of the first sleeve, an interior surface of the second sleeve that defines an internal bore of the second sleeve implant faces the core, and the second sleeve causes the first sleeve to expand outwardly.2. The method of claim 1 , wherein the attaching step comprises engaging an instrument engagement feature at the proximal end of the core with a core engagement feature at a distal end of the shaft.3. The method of claim 1 , wherein the inserting step comprises guiding the first sleeve along the shaft and onto the core.4. The method of claim 3 , wherein the inserting step comprises using a pusher to push the ...

SCAFFOLD AND METHOD FOR IMPLANTING CELLS

A method of creating a synthetic bone implant configured for implantation into a patient is provided. The method includes constructing a synthetic three dimensional composite support structure integrally formed as one piece, the synthetic three dimensional composite support structure including a nonbiodegradable material and having a porous construction with a plurality of passages, wherein the support structure is constructed to have a configuration corresponding to at least one of a bone and a portion of a bone to be replaced in the patient. The method also includes providing the synthetic three dimensional composite support structure to enable placement of the synthetic three dimensional composite support structure in the patient, wherein an outer surface of the support structure is configured to be pressed adjacent the bone, wherein the synthetic three dimensional composite support structure is configured to be positioned in the body to promote growth of tissue in the body of the patient into at least a portion of the synthetic three dimensional composite support structure by having at least a portion of the porous construct adjacent the bone enabling biologic structures to grow into the plurality of passages in the porous construction to securely connect the support structure in place in the body of the patient. 122-. (canceled)23. A cell harvesting system comprising:a robotic mechanism configured to harvest viable cells from a patient.241. The cell harvesting system of claim , wherein the viable cells are at least one of stem cells , embryonic cells , fetal cells , stromal cells , mesenchymal cells , fibroblasts , osteoblasts , myoblasts , reticular cells , smooth muscle cells , chondrocytes , chondroblasts , retinal cells , endothelial cells , endocardial cells , myocardial cells , pericardial cells , liver cells , pancreas cells , renal cells , neural cells , and progenitor cells.2522. The cell harvesting system of claim , further comprising a surface ...

BALLOON CATHETER FOR MULTIPLE ADJUSTABLE STENT DEPLOYMENT

A catheter configured to carry one or more stents and having an inflatable balloon for expanding a stent surrounding the balloon. The catheter is characterized in having a positioner for moving the one or more stents relative to the balloon from a first position in which the stent does not surround the balloon to a second position in which the stent surrounds the balloon. Also disclosed is a method for deploying a stent at a desired location in the vascular system. 1. A stent delivery system , comprising:a catheter having a distal end;an inflatable balloon near the distal end for expanding a stent surrounding the balloon;a plurality of stents carried upon the catheter;a separating mechanism carried upon the catheter, wherein a stent to be expanded is separated from an undeployed adjacent stent via the separating mechanism; anda positioner which is longitudinally slidable along the catheter independently of the plurality of stents such that the positioner is configured to move the plurality of stents relative to the balloon from a first position to a second position in proximity to the distal end so that at least one of the plurality of stents surrounds the balloon.2. The system of wherein the separating mechanism is non-releasable from the distal end of the catheter3. The system of wherein the stents are adapted to be deployed in a blood vessel in any order.4. The system of wherein the positioner comprises a sliding element configured to slide longitudinally along the catheter and push the plurality of stents distally along the catheter so as to move a stent adjacent to the balloon into a position in which it surrounds the balloon.5. The system of wherein the sliding element is attached to a wire extending longitudinally along the length of the catheter and the sliding element slides along the catheter in response to a longitudinal movement of the wire.6. A stent delivery system claim 4 , comprising:a catheter having a distal end;an inflatable balloon near the ...

Patient-modified implant

An orthopedic implant includes a first portion including at least one feature modified to be patient-specific and match the anatomy of a specific patient from a three-dimensional digital image of a patient's joint using computer modeling. The orthopedic implant includes a non-custom inner bone-engaging surface including a plurality of planar surfaces configured for engagement with non-custom bone cuts.

Percutaneously implantable replacement heart valve device and method of making same

A method of making a replacement heart valve device whereby a fragment of biocompatible tissue material is treated and soaked in one or more alcohol solutions and a solution of glutaraldehyde. The dried biocompatible tissue material is folded and rehydrated in such a way that forms a two- or three-leaflet/cusp valve without affixing of separate cusps or leaflets or cutting slits into the biocompatible tissue material to form the cusps or leaflets. After the biocompatible tissue material is folded, it is affixed at one or more points on the outer surface to the inner cavity or a stent.

Prevention of myocardial infarction induced ventricular expansion and remodeling

A method for direct therapeutic treatment of myocardial tissue in a localized region of a heart having a pathological condition. The method includes identifying a target region of the myocardium and applying material directly and substantially only to at least a portion of the myocardial tissue of the target region. The material applied results in a physically modification the mechanical properties, including stiffness, of said tissue. Various devices and modes of practicing the method are disclosed for stiffening, restraining and constraining myocardial tissue for the treatment of conditions including myocardial infarction or mitral valve regurgitation.

Annuloplasty Ring Holder

An annuloplasty ring holder including a head having an upper surface and an annuloplasty ring receiving surface facing opposite the upper surface. The annuloplasty ring holder also includes means for attaching an annuloplasty ring to the annuloplasty ring receiving surface. The means for attaching an annuloplasty ring to the annuloplasty ring receiving surface may include one or more suture guides operatively associated with the head and configured to position one or more sutures to removably associate an annuloplasty ring with the annuloplasty ring receiving surface. The head may include a central hub and more than one spoke radiating out from the central hub. If the head is thus configured, each spoke will include a portion of the annuloplasty ring receiving surface. 1. A method of attaching an annuloplasty ring to an annuloplasty ring holder comprising:providing an annuloplasty ring holder having an upper surface and an annuloplasty ring receiving surface facing opposite the upper surface;attaching an annuloplasty ring to the annuloplasty ring receiving surface with at least one suture such that the annuloplasty ring may be released from the annuloplasty ring holder by severing once a single suture of the at least one suture.2. The method of attaching an annuloplasty ring to an annuloplasty ring holder of further comprising attaching the at least one suture to the annuloplasty ring holder.3. The method of attaching an annuloplasty ring to an annuloplasty ring holder of further comprising attaching the annuloplasty ring to the annuloplasty ring receiving surface with a continuous single length of suture.4. An annuloplasty ring and holder comprising:an annuloplasty ring holder having an upper surface and an annuloplasty ring receiving surface facing opposite the upper surface;an annuloplasty ring; andat least one suture associating the annuloplasty ring with the annuloplasty ring receiving surface such that the annuloplasty ring holder may be disassociated from the ...

Nano-skeletal catalyst

A method of producing a catalyst material with nano-scale structure, the method comprising: introducing a starting powder into a nano-powder production reactor, the starting powder comprising a catalyst material; the nano-powder production reactor nano-sizing the starting powder, thereby producing a nano-powder from the starting powder, the nano-powder comprising a plurality of nano-particles, each nano-particle comprising the catalyst material; and forming a catalyst precursor material from the nano-powder, wherein the catalyst precursor material is a densified bulk porous structure comprising the catalyst material, the catalyst material having a nano-scale structure.

NESTED EXPANDABLE SLEEVE IMPLANT

An expandable implant for treating bone preferably in a minimally invasive manner includes a preferably cylindrical core element extending along a longitudinal axis and preferably a plurality of nestable, expandable sleeves extending along a longitudinal axis for placement radially about the core element. The plurality of nestable sleeves are sequentially insertable over the core element in such a manner that a first nestable sleeve is inserted over the core element and each subsequently inserted nestable sleeve is received between the core element and the previously inserted nestable sleeve such that the insertion of each additional sleeve causes each previously inserted sleeve to outwardly expand. 1. (canceled)2. A system , comprising: a core including a core body that defines a proximal end and a distal end spaced from the proximal end along a distal direction;', 'a first sleeve having a first interior surface that defines a first internal bore, and a first exterior surface opposite the first interior surface, the first sleeve configured to be inserted over the core in the distal direction such that the first interior surface faces the core; and', 'a second sleeve having a second interior surface that defines a second internal bore and a second exterior surface opposite the second interior surface, the second sleeve configured to be inserted in the distal direction between the first sleeve and the core such that the second exterior surface faces the first interior surface, the second interior surface faces the core, and the second sleeve causes the first sleeve to expand outwardly; and, 'a spinal implant havingan insertion instrument having a shaft that releasably attaches to the core.3. The system of claim 2 , wherein the shaft releasably attaches to the proximal end of the core.4. The system of claim 3 , wherein:the proximal end of the core includes an instrument engagement feature; andthe shaft has a proximal end, and a distal end spaced from the proximal end ...

AVIONICS BAY

The invention concerns an avionics bay () for the installation of at least one electrical module (M), comprising a fluid cooling system and a housing () that is complementary to the electrical module (M) and that comprises an open front face () through which the module (M) can be removably installed inside said housing (), and a rear face () on which there are arranged electrical connectors suitable for being connected to the electrical module (M), characterised in that the fluid cooling system comprises a cold plate () that is disposed on the rear face () of the housing () that is suitable for cooling the electrical module (M) when said electrical module (M) is installed inside the housing (). 1. An avionics bay for installation of at least one electrical module comprising a fluid cooling system and a housing which is complementary to the electrical module and which comprises an open front face through which the module can be removably installed inside said housing , and a rear face on which are arranged electrical connectors suitable for being connected to the electrical module , wherein the fluid cooling system comprises a cold plate which is arranged on the rear face of the housing , said cold plate being suitable for cooling the electrical module when said electrical module is installed inside the housing.2. The avionics bay according to claim 1 , comprising at least one guide pin which is arranged on the rear face of the housing to guide displacement of the electrical module inside said housing.3. The avionics bay according to claim 2 , comprising two guide pins.4. The avionics bay according to claim 1 , comprising a damping stop arranged on the rear face of the housing such that the movement of the electrical module is attenuated when said electrical module reaches the rear face of the housing during installation of said electrical module inside said housing.5. The avionics bay according to claim 1 , comprising a door which is arranged at the level of the ...

ANTI-MIGRATION STENT

Embodiments of the disclosure relate to devices, systems and methods of use and manufacture. One such device is a stent. The stent includes a stent body and a coating over at least a portion of the stent body. The coating includes a shape memory polymer having an outer surface. The outer surface defines a first configuration and a second configuration. In the first configuration the outer surface is smooth. In the second configuration, the outer surface includes a micro pattern. 1. A stent comprising:a stent body; anda coating over at least a portion of the stent body, the coating comprising a shape-memory polymer defining an outer surface, the outer surface having a first configuration and a second configuration;in the first configuration the outer surface being smooth and in the second configuration, the outer surface having a micro pattern.2. The stent of claim 1 , wherein the stent body is formed from a polymeric material.3. The stent of claim 1 , wherein the stent body is formed from a metallic material.4. The stent of claim 1 , wherein the stent body is self-expanding.5. The stent of claim 1 , wherein the stent body is balloon-expandable.6. The stent of claim 1 , wherein the outer surface of the shape-memory polymer transitions from the first configuration to the second configuration upon application of heat to the shape-memory polymer.7. The stent of wherein the micro pattern defines a plurality of holes extending through the coating claim 1 , the holes having a cross-section of about 100 nanometers or less.8. The stent of wherein the micro pattern is a repeating pattern along the surface of the coating and at least 75% of the holes are spaced between about 1 and 100 microns apart.9. A stent delivery device comprising:a catheter and a stent, the catheter having an expandable balloon;the stent having a stent body and a coating over at least a portion of the stent body, the coating comprising a shape-memory polymer defining an outer surface, the outer surface ...

IMPLANTABLE PROSTHETIC VALVE WITH NON-LAMINAR FLOW

A prosthetic heart valve can include an expandable support stent, a valve assembly, and a connecting membrane. The support stent can have first and second end portions and can be configured to be radially expandable from a first configuration to a second configuration. The valve assembly can have an inlet portion, an outlet portion, and a plurality of leaflets, and the valve assembly can be supported in the support stent. The connecting membrane can be disposed radially between the support stent and the valve assembly, wherein the support stent and the valve assembly can be connected to the connecting membrane. 1. A prosthetic heart valve , comprising:an expandable support stent having first and second end portions, wherein the support stent is configured to be radially expandable from a first configuration to a second configuration; a valve assembly having an inlet portion, an outlet portion, and a plurality of leaflets, wherein the valve assembly is supported in the support stent; anda connecting membrane extending radially inwardly from the support stent to the valve assembly, wherein the support stent and the valve assembly are connected to the connecting membrane.2. The prosthetic heart valve of claim 1 , wherein the connecting membrane has an inner edge connected to the valve assembly and an outer edge connected to the support stent.3. The prosthetic heart valve of claim 2 , wherein the outer edge of the connecting membrane is connected to the support stent with stitching.4. The prosthetic heart valve of claim 1 , wherein an annular space is defined between the inner surface of the support stent and the outer surface of the valve assembly claim 1 , and sealing material is disposed in the annular spaced to prevent blood from flowing around the valve assembly.5. The prosthetic heart valve of claim 1 , wherein the first configuration is a crimped configuration and the second configuration is a deployed configuration claim 1 , and the valve assembly is spaced ...

Prosthetic device and a system and method for implanting a prosthetic device

A system for implanting a prosthetic device includes a first component of the prosthetic device configured to be disposed in an actual joint and including a first feature. The system further includes a processing circuit configured to determine, based in part on a second component of the prosthetic device that is disposed on an actual bone of the actual joint, a placement of the first component on the same actual bone to obtain a desired relationship between the first component and the second component. The processing circuit is further configured to determine a relationship between the first component and the second component. The second component includes a second feature, and the determined relationship is based at least in part on the first feature and the second feature, and at least one of the first feature and the second feature includes a characteristic that is represented as a virtual feature.

Heart Valve Assemblies

A heart valve assembly comprises a first prosthesis configured to expand from an unexpanded state to an expanded state at which the first annular prosthesis contacts native tissue of a body lumen. The heart valve assembly also comprises a second prosthesis comprising a valve, and a connection adapter that secures the second prosthesis to the first prosthesis, the connection adapter having a multi-lobed circumference. 119-. (canceled)20. A prosthetic valve assembly comprising:a first annular prosthesis having a frame configured to have a first diameter in a collapsed state for introduction into a body lumen and a second diameter in an expanded state for implantation within an annulus of a heart, the first annular prosthesis having a first alignment element; anda second annular prosthesis including a prosthetic valve, the second annular prosthesis having a second alignment element that is configured to align with the first alignment element when the second annular prosthesis is positioned within the first annular prosthesis in the expanded state.21. The prosthetic valve assembly of claim 20 , wherein the first alignment element is a groove that extends in parallel with a longitudinal axis of the first annular prosthesis.22. The prosthetic valve assembly of claim 21 , wherein the second alignment element is a rib that protrudes outwardly from the second annular prosthesis claim 21 , the rib being configured to slide within the groove of the first annular prosthesis when the first annular prosthesis and the second annular prosthesis are mated with each other in vivo.23. The prosthetic valve assembly of claim 22 , wherein when the second annular prosthesis is positioned within the first annular prosthesis the first and second alignment elements prevent rotation of the first annular prosthesis relative to the second annular prosthesis.24. The prosthetic valve assembly of claim 20 , wherein during positioning of the second annular prosthesis within the first annular ...

METHODS AND SYSTEMS FOR PRODUCING AN IMPLANT

A computer implemented method for determining the 3-dimensional shape of an implant to be implanted into a subject includes obtaining a computer readable image including a defective portion and a non-defective portion of tissue in the subject, superimposing on the image a shape to span the defective portion, and determining the 3-dimensional shape of the implant based on the shape that spans the defective portion. 1. A method of fabricating a medical device , the method comprising: '(a) rendering a computer-based three-dimensional representation of a target tissue from computer readable image data of the target tissue wherein the target tissue comprises a portion with a defect and a portion without a defect;', 'obtaining data regarding a shape of the medical device, wherein the shape is determined by(b) mapping an external surface of the computer-generated three-dimensional representation of the target tissue;(c) superimposing onto the mapped external surface a three-dimensional template to span the defective portion by altering the shape of the three-dimensional template to fit at least a portion of the mapped external surface; and(c) determining the shape of the medical device based on the shape of the altered three-dimensional template that spans the defective region to obtain the data regarding the shape of the medical device; andfabricating the medical device at least partially based on using the obtained data regarding the shape of the medical device.2. The method of claim 1 , wherein the image data is obtained from image slices of the target tissue.3. The method of claim 1 , wherein the image data is obtained as one or more voxels of the target tissue.4. The method of claim 1 , wherein the medical device is an implant to be implanted in a subject.5. The method of claim 1 , wherein fabricating the medical device comprises three-dimensional printing at least a portion of the device. This application is a continuation of U.S. application Ser. No. 15/072,607, ...

Methods for Vascular Construction and Products Therefrom

The present invention is directed to vascular tissue constructs or vessels and methods for producing vascular tissue constructs or vessels (ie., fabricated blood vessels), including veins, arteries, capillaries and other vascular structures from a biomaterial foundation or scaffold and epicardial progenitor cells (EPCs) which are seeded onto the biomaterial, exposed to a differentiation medium and differentiated into endothelial, cells, smooth muscle cells and pericytes which self-assemble into vascular tissue associated with N the biomaterial foundation or scaffold.

METHODS AND SYSTEMS FOR PRODUCING AN IMPLANT

A computer implemented method for determining the 3-dimensional shape of an implant to be implanted into a subject includes obtaining a computer readable image including a defective portion and a non-defective portion of tissue in the subject, superimposing on the image a shape to span the defective portion, and determining the 3-dimensional shape of the implant based on the shape that spans the defective portion. 2. The method of claim 1 , wherein the image data is obtained from image slices of the target tissue.3. The method of claim 1 , wherein the image data is obtained as one or more voxels of the target tissue.4. The method of claim 1 , wherein the medical device is an implant to be implanted in a subject.5. The method of claim 1 , wherein fabricating the medical device comprises three dimensional printing at least a portion of the device. This application is a continuation of U.S. application Ser. No. 15/613,476, filed Jun. 5, 2017, which is a continuation of U.S. application Ser. No. 15/072,607, filed Mar. 17, 2016, which is a continuation of U.S. application Ser. No. 14/277,835, filed May 15, 2014, which is a continuation of U.S. application Ser. No. 13/967,738, filed Aug. 15, 2013, which is a continuation of U.S. application Ser. No. 13/616,007, filed Sep. 14, 2012, which is a continuation of U.S. application Ser. No. 13/228,517, filed Sep. 9, 2011, which is a continuation of U.S. application Ser. No. 10/089,467, fifed Mar. 27, 2002, which is a U.S. National Stage Entry of International Application PCT/US2000/022053, filed Aug. 11, 2000, which claims the benefit of U.S. Provisional Application Nos. 60/148,275, 60/148,277, and 60/148,393, which were all filed Aug. 11, 1999. All prior applications are incorporated by reference.The present invention relates to fabricating implants to replace bony structures. More specifically, the invention relates to a system and methodology for fabricating a “drop in” replacement for a particular segment of missing bony ...

SCAFFOLD AND METHOD FOR IMPLANTING CELLS

A method of creating a synthetic bone implant configured for implantation into a patient is provided. The method includes constructing a synthetic three dimensional composite support structure integrally formed as one piece, the synthetic three dimensional composite support structure including a nonbiodegradable material and having a porous construction with a plurality of passages, wherein the support structure is constructed to have a configuration corresponding to at least one of a bone and a portion of a bone to be replaced in the patient. The method also includes providing the synthetic three dimensional composite support structure to enable placement of the synthetic three dimensional composite support structure in the patient, wherein an outer surface of the support structure is configured to be pressed adjacent the bone, wherein the synthetic three dimensional composite support structure is configured to be positioned in the body to promote growth of tissue in the body of the patient into at least a portion of the synthetic three dimensional composite support structure by having at least a portion of the porous construct adjacent the bone enabling biologic structures to grow into the plurality of passages in the porous construction to securely connect the support structure in place in the body of the patient. 122-. (canceled)23. A heart implant comprising:a support structure having a plurality of pores and defining passages configured for growth of blood vessels; andstem cells harvested from at least one soft tissue source of a patient deposited into the pores of the support structure, the stem cells cultured and exposed to at least one environmental condition,wherein the implant is configured to repair a portion of a heart of the patient.24. The heart implant of claim 23 , further comprising fibroblast and endothelial cells harvested from at least one soft tissue source of the patient claim 23 , deposited into the pores of the support structure claim 23 , ...

IMPLANTABLE PROSTHETIC HEART VALVE

A prosthetic heart valve can include a support stent, a valve assembly, and a connection structure. The support stent can have an inlet end portion and an outlet end portion, and can be configured to be radially expandable from a crimped configuration to an expanded configuration. The valve assembly can have an inlet, an outlet, and a plurality of leaflets. The connection structure supports the valve assembly in the support stent such that the inlet of the valve assembly is spaced radially inwardly of the support stent and forms an annular space between an inner surface of the support stent and the valve assembly at the inlet of the valve assembly when the support stent is in the expanded configuration. The annular space can have a width in a radial direction between 0.5 cm and 3 cm. 1. A prosthetic heart valve , comprising:a support stent having an inlet end portion and an outlet end portion, wherein the support stent is configured to be radially expandable from a crimped configuration to an expanded configuration;a valve assembly comprising an inlet, an outlet, and a plurality of leaflets that are moveable between an open position and a closed position, wherein the leaflets in the open position are configured to permit fluid flow from the inlet to the outlet and the leaflets in the closed position are configured to block fluid flow from the outlet to the inlet; anda connection structure that supports the valve assembly in the support stent such that the inlet of the valve assembly is spaced radially inwardly of the support stent and forms an annular space between an inner surface of the support stent and the valve assembly at the inlet of the valve assembly when the support stent is in the expanded configuration, wherein the annular space has a width in a radial direction between 0.5 cm and 3 cm.2. The prosthetic heart valve of claim 1 , wherein the inlet of the valve assembly is disposed between the inlet end portion and the outlet end portion of the support ...

OSTEOARTHRITIS TREATMENT AND DEVICE

A method for treating arthritis of a joint includes identifying a bone lesion in a bone adjacent to the joint; and implanting in the bone a reinforcing member in or adjacent to the bone lesion. A kit for conducting the method includes: (a) at least one reinforcing member having a proximal face adapted to face the joint, a distal face adapted to face away from the joint, and a wedge-shaped edge adapted to pierce bone, wherein the at least one reinforcing member is planar and sterile; and (b) a container adapted to maintain the at least one reinforcing member sterile. Another kit includes: (a) a sterile fluid; (b) a syringe for injecting the fluid into a bone; (c) a curing agent adapted to cure the fluid to polymerize and/or cross-link; and (d) a container adapted to maintain the sterility of contents of the container. 1. (canceled)2. A method of injecting an injectable fluid material into a targeted treatment area in a subchondral region of a first bone adjacent a joint of a patient for treating a bone marrow lesion identified in the subchondral region , the method comprising:identifying a bone marrow lesion (BML) in a subchondral region of a first bone adjacent a joint of a patient, the subchondral region of the first bone occurring under an articular surface of the first bone;creating, in the first bone that contains the bone marrow lesion in the subchondral region, a subchondral injection path to a targeted treatment area for injecting an injectable fluid material into the targeted treatment area, wherein said creating is conducted without creating a void in the targeted treatment area that opens into the overlying articular cartilage of the first bone adjacent the joint so as to preserve an existing condition of the overlying articular cartilage of the first bone adjacent the joint; andinjecting an injectable fluid material into the targeted treatment area via the subchondral injection path, wherein the injectable fluid material is resorbable and osteoconductive ...

Mixed refrigerants in ethylene recovery

The present invention is a process of high efficiency rectification zone separation of cracked or other ethylene-containing gas chilled primarily by two closed mixed refrigerant loops and at least part of the dephlegmated overhead gas. The composition of the mixed refrigerants is optimally chosen to obtain an extremely close approach between the process condensation temperatures in the high efficiency rectification zone and the temperature of the chilling streams. An approach of about 3° F. to 8° F. can be achieved for the full condensation curve in the high efficiency rectification zone operating with either ethane or naphtha derived cracked gas. Highly reliable and stable operation is obtained by closed refrigeration loops in the present invention, in addition to reducing high efficiency rectification zone design cost.

Separation of hydrogen-hydrocarbon gas mixtures using closed-loop gas expander refrigeration

A method for the recovery of hydrogen and one or more hydrocarbons having one or more carbon atoms from a feed gas containing hydrogen and the one or more hydrocarbons, which process comprises cooling and partially condensing the feed gas to provide a partially condensed feed; separating the partially condensed feed to provide a first liquid stream enriched in the one or more hydrocarbons and a first vapor stream enriched in hydrogen; further cooling and partially condensing the first vapor stream to provide an intermediate two-phase stream; and separating the intermediate two-phase stream to yield a further-enriched hydrogen stream and a hydrogen-depleted residual hydrocarbon stream. Some or all of the cooling is provided by indirect heat exchange with cold gas refrigerant generated in a closed-loop gas expander refrigeration cycle.

Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance

A medical implant of ultrahigh molecular weight polyethylene having an improved balance of wear properties and oxidation resistance is prepared by irradiating a preform of ultrahigh molecular weight polyethylene, annealing the irradiated preform in the absence of oxygen to a temperature at or above the onset of melting temperature, and forming an implant from the stabilized cross-linked polymer. Implants prepared according to the process of the present invention have comparable oxidation resistance and superior wear performance compared to unirradiated ultrahigh molecular weight polyethylene.

Passive-active thermosyphon

A thermosyphon for use in frozen or unfrozen soil includes an evaporator tion embedded in the soil, a condenser section exposed to ambient air, an intermediate section connecting the two sections and a heat exchanger connected to a mechanical refrigeration source and operable to cool either the condenser or the intermediate section of the thermosyphon during periods when the ambient temperature is higher than that at which passive thermosyphonic cooling occurs.

Readjustable Locking Plate Hole

A bone plate comprises a locking hole extending through the bone plate from a top surface to a bottom surface thereof. The locking hole is threaded and sized and shaped to lockingly receive a correspondingly threaded head of a bone fixation element therethrough. The bone plate further comprises a first plate relief extending at least partially through a thickness of the plate and separated from the locking hole to define a first weakened portion of the bone plate. The first plate relief extends around a portion of a circumference of the locking hole.

Method for surface treatment of implants or prosthesis made of titanium

Separate and successive treatment in carried on a portion of the implant using three acids: fluohydric, sulfuric and hydrochloric acids. An evenly distributed roughness with a broad relief is thus obtained. Said surface is then contacted with a plasma rich in growth factors.

Process and device in respect of a three-dimensional body usable in the human body

Input data (ID) representative of a model are stored in a computer installation (ST) in memory cells (DF1). The data-processing equipment operates with a program which is directed, by means of first signals (i1) generated by one or more first activations of terminal members (TER'), to generate, with the aid of the said input data, representations of the surface of the body in the form of contours of a number of vertical sections extending through the centre axis of the body. The contours are presented one at a time on the screen of the computer installation. By means of second signals (i2), the said program is directed to simulate on the cross-sections/contours concerned an alteration or extension attributable to a variant of the model. With third signals (i3), the program is directed to store in memory cells (DF2) data attributable to the variant simulated by means of the altered or extended vertical sections. The latter data form or are utilized to generate output data (UD) from the installation (ST). It is proposed that Figure 6 should accompany the abstract.

Method for making a perfected medical model on the basis of digital image information of a part of the body

Method for making a perfected medical model on the basis of digital image information of a part of the body, according to which this image information of a part of the body is converted, by means of what is called the rapid prototyping technique and thus with a processing unit (4) and a rapid prototyping machine (5), into a basic model (9) of which at least a part perfectly shows the positive or negative form of at least a part of the part of the body, characterized in that at least a functional element (10) with a useful function is added to the basic model (6) as a function of the digital information and possibly as a function of additional external information.

Purification of carbon dioxide

Impure carbon dioxide (“CO 2 ”) comprising a first contaminant selected from the group consisting of oxygen (“O 2 ”) and carbon monoxide (“CO”) is purified by separating expanded impure carbon dioxide liquid in a mass transfer separation column system. The impure carbon dioxide may be derived from, for example, flue gas from an oxyfuel combustion process or waste gas from a hydrogen (“H 2 ”) PSA system.

Apparatus and method for treating glaucoma

Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involve bypassing diseased trabecular meshwork with the use of a seton implant. The seton implant is used to prevent a healing process known as filling in, which has a tendency to close surgically created openings in the trabecular meshwork. The surgical method and novel implant are addressed to the trabecular meshwork, which is a major site of resistance to outflow in glaucoma. In addition to bypassing the diseased trabecular meshwork at the level of the trabecular meshwork, existing outflow pathways are also used or restored. The seton implant is positioned through the trabecular meshwork so that an inlet end of the seton implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.

Graft prosthesis, materials and methods

A graft prostheses ( 11 ), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

Multi-formed collagenous biomaterial medical device

The invention involves a submucosa tissue that has the capability of being shape formed or shape configured. The submucosa involves a purified form of submucosa tissue. Optionally, the submucosa can be packaged in such a manner to permit sterility or maintain sterility of the submucosa.

Multistoreyed bath condenser

The invention relates to a multistoreyed bath condenser comprising a condenser block (1) provided with evaporation passages (8) for a liquid and condensation passages (2) for a heating medium in addition to possessing at least two vertically superimposed circulation sections (7) . The evaporation passages (8) are respectively provided with at least one inlet (9) for a fluid on the lower end of the circulation section (7) and at least one outlet on the upper end of a circulation section (10). A reservoir for liquid is provided for each circulation section (7). Said reservoir is fluidically connected to the inlet 9) and outlet (10) of the circulation section (7) and is fitted with a gas conduit (18). The inlet to the gas conduit (18) is not located in the region in front of the side (12) of the circulation section (7) where the outlet (10) of the circulation section (7) is arranged.

Multistoreyed bath condenser

The invention relates to a multistoreyed bath condenser comprising a condenser block (1) provided with evaporation passages (8) for a liquid and condensation passages (2) for a heating medium. The condenser block has at least two vertically superimposed circulation sections (7) . The evaporation passages (8) are respectively provided with at least one inlet (9) for a fluid on the lower end of a circulation section (7) and at least one outlet on the upper end of a circulation section (10). The outlets (10) and inlets (9) located on the same side (12) of the condenser block (1) are exclusively provided with means (7,30) for supplying a liquid.

Heart valve prosthesis and methods of manufacture and use

A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

Device for fastening and anchoring heart valve prostheses

Die Erfindung betrifft eine Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen, die im Wesentlichen aus drahtförmigen miteinander verbundenen Elementen gebildt ist. Aufgabengemäß soll eine solche Vorrichtung minimal invasiv durch die Aorta durch kleines Zusammenfalten implantiert und am Implantationsort entfaltet werden können, wobei ein sicherer Halt und eine sichere Abdichtung gegenüber der Aortenwand gewährleistet sind. Zur Lösung dieser Aufgabe sind zur Befestigung und Abstützung einer Herzklappenprothese drei jeweils gleiche Paare von Bügeln in jeweils um 120 DEG versetzter Anordnung miteinander mittels Festkörpergelenken verbunden. Diese Festkörpergelenke erfüllen die Funktion von Drehlagern. The invention relates to a device for fastening and anchoring heart valve prostheses, which is formed essentially from wire-shaped interconnected elements. According to the task, such a device should be able to be implanted minimally invasively through the aorta by small folding and unfolded at the implantation site, with a secure hold and a secure seal against the aortic wall being guaranteed. To solve this problem, three identical pairs of stirrups are connected to one another by means of solid-state joints in order to fasten and support a heart valve prosthesis, each in an arrangement offset by 120 °. These solid-state joints fulfill the function of pivot bearings.

Extra-articular implantable mechanical energy absorbing systems and implantation method

A system and method for sharing and absorbing energy between body parts. In one aspect, the method involves identifying link pivot locations, fixing base components and minimally invasive insertion techniques. In one particular aspect, the system facilitates absorbing energy between members forming a joint such as between articulating bones.

Preparation of polymeric surfaces via covalently attaching polymers

A method wherein surfaces are provided with desired characteristics of a polymer by covalently bonding polymer molecules to the surface through external activation of latent reactive groups carried by the polymer molecules is disclosed. The initial surfaces are free of chemical groups added by surface pretreatment and which chemically participate in the covalent bonding process. This application is a divisional of application Ser. No. 223,149, filed July 22, 1988 now abandoned, which is a continuation-in-part of U.S. application Ser. No. 138,226, filed Dec. 24, 1987 now abandoned, which is a continuation-in-part of U.S. application Ser. No. 920,567, filed Oct. 17, 1986 now abandoned and of U.S. Ser. No. 108,765, filed Oct.15, 1987 now U.S. Pat. No. 4,973,493 which is a continuation-in-part of U.S. application Ser. No. 428,074 now U.S. Pat. No. 4,722,906 filed Sept. 29, 1982, and of U.S. application Ser. No. 920,567 filed Oct. 17, 1986.

Coating compositions

An article (e.g., in the form of an implantable medical article) in the form of a support material bearing an intermediate layer consisting of a functional silicone polymer formulation, the intermediate layer having photoimmobilized thereon a target compound. In another aspect, a method of fabricating an article including the steps of providing a support material, applying an intermediate layer and photoimmobilizing a target compound onto the intermediate layer, and optionally, reforming the support material into a final desired article.

Cooling system for machine tools

Implant with electrical transponder marker

A passive transponder may be encoded with a number or code of up to 64 binary bits and then mounted to virtually any prosthesis implanted in a human, such as a breast implant. After implantation, the transponder's code may be conveniently read with a hand held electromagnetic reader which may merely be brought within proximity of the transponder. The encoded transponder may thus be read in a non-invasive procedure and without the use of any sophisticated or potentially harmful medical equipment or technology such as X-ray. The information encoded in the transponder may correspond to patient demographics and implant data to aid in tracking the implant's manufacturer and use for medical as well as legal reasons.

Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis

A valve prosthesis (9) for implantation in the body by use of catheter (11) comprises a stent made from an expandable cylinder-shaped thread structure (2,3) comprising several spaced apices (4). The elastically collapsible valve (4) is mounted on the stent as the commissural points (5) of the valve (6) are secured to the projecting apices (4). The valve prosthesis (9) can be compressed around the balloon means (13) of the balloon catheter (11) and be inserted in a channel, for instance in the aorta (10). When the valve prosthesis is placed correctly the balloon means (13) is inflated thereby expanding the stent and wedging it against the wall of aorta. The balloon means is provided with beads (14) to ensure a steady fastening of the valve prosthesis on the balloon means during insertion and expansion. The valve prosthesis (9) and the balloon catheter (11) make it possible to insert a cardiac valve prosthesis without a surgical operation comprising opening the thoracic cavity.

Endovascular aortic valve replacement

The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.

Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same

An inflatable prosthetic cardiovascular valve which is constructed so as to be initially deployable in a deflated "collapsed" configuration wherein the valve may be passed through the lumen of a cardiovascular catheter and subsequently inflated to an "operative" configuration so as to perform its intended valving function at its intended site of implantation within the cardiovascular system. The inflated valve may be held in place by mechanical means (e.g., hooks, projections), by chemical adhesive or through biological assimilation by the heart tissue.

System and method for implanting cardiac valves

A valve prosthesis (9) for implantation in the body by use of catheter (11) comprises a stent made from an expandable cylinder-shaped thread structure (2,3) comprising several spaced apices (4). The elastically collapsible valve (4) is mounted on the stent as the commissural points (5) of the valve (6) are secured to the projecting apices (4). The valve prosthesis (9) can be compressed around the balloon means (13) of the balloon catheter (11) and be inserted in a channel, for instance in the aorta (10). When the valve prosthesis is placed correctly the balloon means (13) is inflated thereby expanding the stent and wedging it against the wall of aorta. The balloon means is provided with beads (14) to ensure a steady fastening of the valve prosthesis on the balloon means during insertion and expansion. The valve prosthesis (9) and the balloon catheter (11) make it possible to insert a cardiac valve prosthesis without a surgical operation comprising opening the thoracic cavity.

Artificial heart valve and method and device for implanting the same

An artificial heart valve comprises a relatively rigid stent member having a first cylindrical shape and a flexible valve disposed in the stent member, the stent member being self-expandable to a second cylindrical shape and collapsible to its first cylindrical shape. The valve comprises a circular portion comprising a plurality of leaflets extending from the periphery of the circular portion towards the center thereof, the leaflets being configured to allow for flow of blood through the valve in one direction only. The diameter of the circular portion is substantially the same as the inside diameter of the stent member when the stent member is in its second cylindrical shape, the valve member being attached to the stent member.

Artificial graft and implantation method

An intraluminal grafting system includes a hollow graft which has a proximal staple positioned proximate its proximal end and a distal staple adapted proximate its distal end. The system includes a capsule for transporting the graft through the lumen and for positioning the proximal end of the graft upstream in a lumen which may be a blood vessel or artery. A tube is connected to the capsule and extends to exterior the vessel for manipulation by the user. A catheter is positioned within the tube to extend from the cavity and through the graft to exterior the body. The catheter has an inflatable membrane or balloon proximate the distal end thereof which is in communication via a channel with inflation and deflation means located exterior the vessel. With the inflatable membrane deflated, the capsule is positioned in the lumen and manipulated to a desired location. The inflatable membrane is manipulated by the rod away from the graft. The force exerted by the inflatable membrane and the structure of the staples urges the staples in the vessel wall, retaining the graft in position. The remainder of the intraluminal grafting system is then removed from the corporeal vessel.

Device for regulating the flow of blood through the blood system

A valve prosthesis is disclosed which is implantable within a vein or other blood vessel of a patient using a minimally-invasive surgical procedure. The prosthesis includes a tubular wire frame which presses radially outward against the inner walls of the blood vessel following implantation to hold the prosthesis in position. Multiple flow-resistive pockets that open and close in response to changes in blood flow direction are attached to the frame to impede the flow of blood in the reverse direction. The prosthesis is implanted using an introducer catheter which holds the prosthesis in a radially-compressed state as the prosthesis is inserted into and positioned within the blood vessel.

Replacement atrioventricular heart valve

A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either “tacked” at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

Rolled minimally-invasive heart valves and methods of use

Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.

Prosthetic valve for transluminal delivery

A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchor may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand within the deficient native valve, and the anchor engages the lumen wall.

Valve prosthesis for implantation in the body

A valve prosthesis ( 9 ) for implantation in the body by use of catheter ( 11 ) comprises a stent made from an expandable cylinder-shaped thread structure ( 2,3 ) comprising several spaced apices ( 4 ). The elastically collapsible valve ( 6 ) is mounted on the stent as the commissural points ( 5 ) of the valve ( 6 ) is secured to the projecting apices ( 4 ). The valve prosthesis ( 9 ) can be compressed around the balloon means ( 13 ) of the balloon catheter ( 11 ) and be inserted in a channel, for instance in the aorta ( 10 ). When the valve prosthesis is placed correctly the balloon means ( 13 ) is inflated thereby expanding the stent and wedging it against the wall of the aorta. The balloon means is provided with beads ( 14 ) to ensure a steady fastening of the valve prosthesis on the balloon means during insertion and expansion. The valve prosthesis ( 9 ) and the balloon catheter ( 11 ) make it possible to insert a cardiac valve prosthesis without a surgical operation comprising opening the thoracic cavity.

Valve prosthesis for implantation in the body and a catheter for implanting such valve prosthesis

A valve prosthesis for implantation in the body by use of a catheter includes a stent made from an expandable cylinder-shaped thread structure having several spaced apices. The elastically collapsible valve is mounted on the stent as the commissural points of the valve are secured to the projecting apices.

Methods for removing embolic material in blood flowing through a patient's ascending aorta

The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.

Replacement semilunar heart valve

A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either “tacked” at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

Replacement atrioventricular heart valve

A replacement heart valve is configured to replace a native atrioventricular heart valve (mitral or tricuspid valve, positioned between an atrial chamber and a ventricular chamber). The replacement valve includes a a thin and flexible wall portion having no more than two leaflets. Two securement locations adjacent the outlet end of the valve are adapted to be attached to respective papillary muscles. The unconstrained regions between the securement locations flex inwardly into and out of engagement with each other in response to blood pressure in order to close and open the valve. The leaflets engage each other along a line of commissure.

Replacement semilunar heart valve

A method is disclosed for using tubular material to replace a semilunar heart valve (i.e., an aortic or pulmonary valve). To create such a replacement valve, the native valve cusps are removed from inside an aorta or pulmonary artery, and the inlet end of a tubular segment is sutured to the valve annulus. The outlet (distal) end of the tube is either “tacked” at three points distally, or sutured longitudinally along three lines; either method will allow the flaps of tissue between the suture lines to function as movable cusps. This approach generates flow patterns that reduce turbulence and closely duplicate the flow patterns of native semilunar valves. An article of manufacture is also disclosed, comprising a sterile biocompatible synthetic material which has been manufactured in tubular form, by methods such as extrusion or coating a cylindrical molding device, to avoid a need for a suture line or other seam to convert a flat sheet of material into a tubular shape. The synthetic tube is packaged within a sealed watertight enclosure that maintains sterility of the tube.

Replacement heart valve

A prosthetic heart valve has leaflets made of a thin and flexible material. The side edges of adjacent leaflets are sewn together so as to form a substantially tubular valve structure having an in-flow end and an out-flow end. Each of the leaflets is adapted to flex inwardly into and out of engagement with another leaflet so as to close and open the valve in response to force by blood pressure. The leaflets are configured so that a portion of the inner face of each leaflet is in a facing relationship with a portion of the inner face of an adjacent leaflet.

Methods for regulating the flow of blood through the blood system

A valve prosthesis is disclosed which is implantable within a vein or other blood vessel of a patient using a minimally-invasive surgical procedure. The prosthesis includes a tubular wire frame which presses radially outward against the inner walls of the blood vessel following implantation to hold the prosthesis in position. Multiple flow-resistive pockets that open and close in response to changes in blood flow direction are attached to the frame to impede the flow of blood in the reverse direction. The prosthesis is implanted using an introducer catheter which holds the prosthesis in a radially-compressed state as the prosthesis is inserted into and positioned within the blood vessel.

Artificial graft and implantation method

An intraluminal grafting system includes a hollow graft which has a proximal staple positioned proximate its proximal end and a distal staple adapted proximate its distal end. The system includes a capsule for transporting the graft through the lumen and for positioning the proximal end of the graft upstream in a lumen which may be a blood vessel or artery. A tube is connected to the capsule and extends to exterior the vessel for manipulation by the user. A catheter is positioned within the tube to extend from the cavity and through the graft to exterior the body. The catheter has an inflatable membrane or balloon proximate the distal end thereof which is in communication via a channel with inflation and deflation means located exterior the vessel. With the inflatable membrane deflated, the capsule is positioned in the lumen and manipulated to a desired location. The inflatable membrane is manipulated by the rod away from the graft. The force exerted by the inflatable membrane and the structure of the staples urges the staples in the vessel wall, retaining the graft in position. The remainder of the intraluminal grafting system is then removed from the corporeal vessel.

FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION

Endovascular aortic valve replacement

The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: (1) a prosthetic valve device, (2) a valve introducer device, (3) an intraluminal procedure device, (4) a procedure device capsule, and (5) a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.

Method of replacing heart valves using flexible tubes

This invention comprises a method of using tubular material to replace a heart valve during cardiac surgery. To create a replacement atrioventricular (mitral or tricuspid) valve, the tube inlet is sutured to a valve annulus from which the native leaflets have been removed, and the tube outlet is sutured to papillary muscles in the ventricle. To create a semilunar (aortic or pulmonary) valve, the tube inlet is sutured to an annulus from which the native cusps have been removed, and the tube is either "tacked" at three points distally inside the artery, or sutured longitudinally along three lines; this allows the flaps of tissue between the three fixation points at the valve outlet to function as movable cusps. These approaches generate flow patterns that closely duplicate the flow patterns of native valves. One preferred tubular material comprises submucosal tissue from a small intestine, from the same patient who is undergoing the cardiac operation; this eliminates the risk of immune rejection and the need to treat the tissue to reduce antigenicity. Intestinal tissue from human cadavers or animals such as genetically engineered hypoallergenic pigs can also be used, if properly treated, or a biocompatible synthetic tubular material can be used.

Inrichting voor het reguleren van de bloedsomloop.

Implantable medical device characterization system

A system for enabling the acquisition from outside the body of a patient of data pertaining to a medical device implanted therein. A characterization tag is secured to the medical device prior to the implantation thereof. The characterization tag is powered by energy absorbed through the mutual inductive coupling of circuitry in the characterization tag with an alternating magnetic field generated outside the body of the patient. That circuitry in the characterization tag is selectively loaded and unloaded in a predetermined sequence of loading conditions that correspond to data about the implanted medical device. The alternating magnetic field is generated in a characterization probe, moveable external to the body of the patient. The probe includes electrical circuitry for sensing variations in the amount of energy absorbed from the field by the characterization tag. The characterization tag is secured to the exterior of the medical device by a biocompatible potting material in a characterization tag recess or, if the medical device is assembled from a plurality of constituent parts, by permanently capturing the characterization tag between a pair of these parts. Two single fluid reservoir access ports, a double fluid reservoir access port, a septum-less access port, and prosthetic hip joint are disclosed employing the system.