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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 9280. Отображено 100.
05-01-2012 дата публикации

Nanoelectronic differential amplifiers and related circuits implemented on a segment of a graphene nanoribbon

Номер: US20120001689A1
Автор: Lester F. Ludwig
Принадлежит: Pike Group LLC

A multiple transistor differential amplifier is implemented on a segment of a single graphene nanoribbon. Differential amplifier field effect transistors are formed on the graphene nanoribbon from a first group of electrical conductors in contact with the graphene nanoribbon and a second group of electrical conductors insulated from, but exerting electric fields on, the graphene nanoribbon thereby forming the gates of the field effect transistors. A transistor in one portion of the graphene nanoribbon and a transistor in another portion of the graphene nanoribbon are responsive to respective incoming electrical signals. A current source, also formed on the graphene nanoribbon, is connected with the differential amplifier, and the current source and the differential amplifier operating together generate an outgoing signal responsive to the incoming electrical signal. In an example application, the resulting circuit can be used to interface with electrical signals of nanoscale sensors and actuators,

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Номер записи: 1
02-02-2012 дата публикации

Aliphatic amine based nanocarbons for the absorption of carbon dioxide

Номер: US20120024153A1
Автор: Andrew R. Barron, Eoghan Dillon
Принадлежит: William Marsh Rice University

A composition of matter, and method to make same, for a nano-based material including a nanocarbon support to which is attached an aliphatic amine. In particular, the composition of matter is an aliphatic amine-nanocarbon material that includes a nanocarbon (NC) support, such as C 60 , nano-graphite, graphene, nanocarbon ribbons, graphite intercalation compounds, graphite oxide, nano-coal, nanohorns, and combinations thereof, and further includes an aliphatic amine, such as polyethyleneimine (PEI).

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Номер записи: 2
02-02-2012 дата публикации

Method of forming a non-volatile electron storage memory and the resulting device

Номер: US20120028429A1
Автор: Gurtej Sandhu, Shubneesh Batra
Принадлежит: Individual

The invention provides a method of forming an electron memory storage device and the resulting device. The device comprises a gate structure which, in form, comprises a first gate insulating layer formed over a semiconductor substrate, a self-forming electron trapping layer of noble metal nano-crystals formed over the first gate insulating layer, a second gate insulating layer formed over the electron trapping layer, a gate electrode formed over the second gate insulating layer, and source and drain regions formed on opposite sides of the gate structure.

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Номер записи: 3
16-02-2012 дата публикации

Method for manufacturing porous structure and method for forming pattern

Номер: US20120037594A1
Автор: Koji Asakawa, Toshiro Hiraoka, Yasuyuki Hotta, Yoshihiro Akasaka
Принадлежит: Individual

A pattern forming material contains a block copolymer or graft copolymer and forms a structure having micro polymer phases, in which, with respect to at least two polymer chains among polymer chains constituting the block copolymer or graft copolymer, the ratio between N/(Nc−No) values of monomer units constituting respective polymer chains is 1.4 or more, where N represents total number of atoms in the monomer unit, Nc represents the number of carbon atoms in the monomer unit, No represents the number of oxygen atoms in the monomer unit.

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Номер записи: 4
16-02-2012 дата публикации

Contacts for Nanowire Field Effect Transistors

Номер: US20120037880A1
Автор: Guy M. Cohen, Jeffrey W. Sleight, Sarunya Bangsaruntip, Shreesh Narasimha
Принадлежит: International Business Machines Corp

A method for forming a nanowire field effect transistor (FET) device includes forming a nanowire over a semiconductor substrate, forming a gate stack around a portion of the nanowire, forming a capping layer on the gate stack, forming a spacer adjacent to sidewalls of the gate stack and around portions of nanowire extending from the gate stack, forming a hardmask layer on the capping layer and the first spacer, forming a metallic layer over the exposed portions of the device, depositing a conductive material over the metallic layer, removing the hardmask layer from the gate stack, and removing portions of the conductive material to define a source region contact and a drain region contact.

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Номер записи: 5
23-02-2012 дата публикации

Magnetic-core polymer-shell nanocomposites with tunable magneto-optical and/or optical properties

Номер: US20120043495A1
Автор: Alejandra Lopez-Santiago, Palash Gangopadhyay, Robert A. Norwood
Принадлежит: Arizona Board of Regents of University of Arizona

Methods are disclosed for synthesizing nanocomposite materials including ferromagnetic nanoparticles with polymer shells formed by controlled surface polymerization. The polymer shells prevent the nanoparticles from forming agglomerates and preserve the size dispersion of the nanoparticles. The nanocomposite particles can be further networked in suitable polymer hosts to tune mechanical, optical, and thermal properties of the final composite polymer system. An exemplary method includes forming a polymer shell on a nanoparticle surface by adding molecules of at least one monomer and optionally of at least one tethering agent to the nanoparticles, and then exposing to electromagnetic radiation at a wavelength selected to induce bonding between the nanoparticle and the molecules, to form a polymer shell bonded to the particle and optionally to a polymer host matrix. The nanocomposite materials can be used in various magneto-optic applications.

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Номер записи: 6
23-02-2012 дата публикации

Sea-of-fins structure on a semiconductor substrate and method of fabrication

Номер: US20120043597A1
Автор: Chun-Yung Sung, Howard H. Chen, Jack A. Mandelman, Louis C. Hsu
Принадлежит: International Business Machines Corp

A semiconductor device and a method of fabricating a semiconductor device, wherein the method comprises forming, on a substrate, a plurality of planarized fin bodies to be used for customized fin field effect transistor (FinFET) device formation; forming a nitride spacer around each of the plurality of fin bodies; forming an isolation region in between each of the fin bodies; and coating the plurality of fin bodies, the nitride spacers, and the isolation regions with a protective film. The fabricated semiconductor device is used in customized applications as a customized semiconductor device.

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Номер записи: 7
23-02-2012 дата публикации

Releasable nonvolatile mass-label molecules

Номер: US20120046180A1
Автор: Christopher H. Becker, Daniel J. Pollart, Joseph A. Monforte, Thomas A. Shaler
Принадлежит: Sequenom Inc

Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents.

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Номер записи: 8
23-02-2012 дата публикации

Automated detection and counting of biomolecules using nanoparticle probes

Номер: US20120046191A1
Автор: Benjamin K. Scholl, Brian R. Long, Tania Q. Vu
Принадлежит: Oregon Health Science University

An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage), which can automatically reposition the transparent membrane or slides for image capture at varying locations. A microscope can be used for providing a light source to fluoresce the nanocrystals and for providing the magnification needed for image capture. Once one or more images are captured, the nanoparticles can be automatically counted using post-processing software that maintains a total count across multiple images, if desired.

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Номер записи: 9
15-03-2012 дата публикации

Large Scale Patterned Growth of Aligned One-Dimensional Nanostructures

Номер: US20120061348A1
Автор: Christopher J. Summers, Elton D. Graugnard, Jeffrey King, Xudong Wang, Zhong L. Wang
Принадлежит: Georgia Tech Research Corp

A method of making nanostructures using a self-assembled monolayer of organic spheres is disclosed. The nanostructures include bowl-shaped structures and patterned elongated nanostructures. A bowl-shaped nanostructure with a nanorod grown from a conductive substrate through the bowl-shaped nanostructure may be configured as a field emitter or a vertical field effect transistor. A method of separating nanoparticles of a desired size employs an array of bowl-shaped structures.

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Номер записи: 10
29-03-2012 дата публикации

Alternating Bias Hot Carrier Solar Cells

Номер: US20120073657A1
Автор: Dale A. McNeill, Hussein S. El-Ghoroury, Selim E. Guncer
Принадлежит: Ostendo Technologies Inc

Extremely high efficiency solar cells are described. Novel alternating bias schemes enhance the photovoltaic power extraction capability above the cell band-gap by enabling the extraction of hot carriers. In conventional solar cells, this alternating bias scheme has the potential of more than doubling their yielded net efficiency. In solar cells incorporating quantum wells (QWs) or quantum dots (QDs), the alternating bias scheme has the potential of extending such solar cell power extraction coverage, possibly across the entire solar spectrum, thus enabling unprecedented solar power extraction efficiency. Within such cells, a novel alternating bias scheme extends the cell energy conversion capability above the cell material band-gap while the quantum confinement structures are used to extend the cell energy conversion capability below the cell band-gap. Light confinement cavities are incorporated into the cell structure to allow the absorption of the cell internal photo emission, thus further enhancing the cell efficiency.

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Номер записи: 11
19-04-2012 дата публикации

Compositions comprising a radiosensitizer and an anti-cancer agent and methods of uses thereof

Номер: US20120093918A1
Автор: Gabriel Charest, Leon Sanche
Принадлежит: SOCPRA Sciences Sante et Humaines sec

A combination of an anti-cancer agent and a metal radiosensitizer potentiates the radiotherapy of cancer. Said anti-cancer agent is preferably cisplatin while the metal radiosensitizer is preferably gold nanoparticles. Both the anti-cancer agent and the metal radiosensitizer bind to DNA and potentiate the radiotherapy of cancer by synergistically increases the amount of double strand breaks induced by the radiation. The anti-cancer agent and the metal radiosensitizer may be encapsulated in liposomes.

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Номер записи: 12
03-05-2012 дата публикации

Method of Selective Separation Of Semiconducting Carbon Nanotubes, Dispersion Of Semiconducting Carbon Nanotubes, And Electronic Device Including Carbon Nanotubes Separated By Using The Method

Номер: US20120104328A1
Автор: Hang-woo Lee, Jong-min Kim, Young-Jun Park, Zhenan Bao
Принадлежит: Leland Stanford Junior University, SAMSUNG ELECTRONICS CO LTD

According to example embodiments, a method includes dispersing carbon nanotubes in a mixed solution containing a solvent, the carbon nanotubes, and a dispersant, the carbon nanotubes including semiconducting carbon nanotubes, the dispersant comprising a polythiophene derivative including a thiophene ring and a hydrocarbon sidechain linked to the thiophene ring. The hydrocarbon sidechain includes an alkyl group containing a carbon number of 7 or greater. The hydrocarbon sidechain may be regioregularly arranged, and the semiconducting carbon nanotubes are selectively separated from the mixed solution. An electronic device includes semiconducting carbon nanotubes and the foregoing described polythiophene derivative.

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Номер записи: 13
10-05-2012 дата публикации

Method for detecting an analyte gas using a gas sensor device comprising carbon nanotubes

Номер: US20120111093A1
Автор: Fikret Nuri Kirkbir, Leonid Grigorian, Robert L. Gump, Sean Imtiaz Brahim, Steven G. Colbern
Принадлежит: Individual

This invention relates generally to gas sensors comprising organized assemblies of carbon and non-carbon compounds. The invention also relates to devices containing such gas sensors and analysis units. In preferred embodiments, the organized assemblies of the instant invention take the form of nanorods or their aggregate forms. More preferably, a nanorod is made up of a carbon nanotube filled, coated, or both filled and coated by a non-carbon material. The invention further relates to a method for detecting or quantitating an analyte gas.

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Номер записи: 14
17-05-2012 дата публикации

Small interfering rna delivery

Номер: US20120121689A1
Автор: Andrew David Bacon, Gregory Gregoriadis, Peter Laing
Принадлежит: Lipoxen Technologies Ltd

A liposomal siRNA composition is described. The liposomes are formed of neutral liposome forming components, and the composition comprising additionally sugar. The composition provides reduced expression of target gene, without causing systemic toxicity. The composition is produced by a dehydration-rehydration technique to provide high yields and good control of liposome size.

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Номер записи: 15
07-06-2012 дата публикации

Aptamer bioconjugate drug delivery device

Номер: US20120141551A1
Автор: Aareet Krsna GANESH SHERMON, Abdel Rahman ELSAYED, Ian J. Mclennan, Juewen Liu, Nathan Jones, Ryan WAGNER, Steven Bloembergen
Принадлежит: Ecosynthetix Ltd

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

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Номер записи: 16
07-06-2012 дата публикации

Multi-Layer Method for Formation of Registered Arrays of Cylindrical Pores in Polymer Films

Номер: US20120141741A1
Автор: Dan B. Millward
Принадлежит: Individual

Methods for fabricating sublithographic, nanoscale polymeric microstructures utilizing self-assembling block copolymers, and films and devices formed from these methods are provided.

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Номер записи: 17
26-07-2012 дата публикации

Optical materials, optical components, and methods

Номер: US20120187367A1
Автор: John R. Linton, Patrick Landreman, Rohit Modi
Принадлежит: QD Vision Inc

An optical component including an optical material comprising quantum confined semiconductor nanoparticles, wherein at least a portion of the nanoparticles are in a charge neutral state. Further disclosed is an optical component including an optical material comprising quantum confined semiconductor nanoparticles, wherein at least a portion of the nanoparticles are in a charge neutral state, and wherein the optical material is at least partially encapsulated. Methods, optical materials, and devices are also disclosed.

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Номер записи: 18
26-07-2012 дата публикации

Acoustically sensitive drug delivery particles comprising non-lamellar forming phosphatidylcholine

Номер: US20120189689A1
Автор: Cecilia Leal Lauten, Esben A. Nilssen, Karen Sibylla RØGNVALDSSON, Sigrid L. Fossheim, Tove J. Evjen
Принадлежит: EPITARGET AS

Novel acoustically sensitive drug carrying particles comprising non-lamellar forming lipids are disclosed, as well as uses and methods thereof. The drug carrying particles accumulate in the diseased target tissue and efficiently release their payload upon exposure to acoustic energy.

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Номер записи: 19
02-08-2012 дата публикации

Therapeutic Inhibitor of Vascular Smooth Muscle Cells

Номер: US20120195951A1
Автор: Lawrence L. Kunz, Peter G. Anderson
Принадлежит: Individual

Methods are provided for inhibiting stenosis following vascular trauma or disease in a mammalian host, comprising administering to the host a therapeutically effective dosage of a therapeutic conjugate containing a vascular smooth muscle binding protein that associates in a specific manner with a cell surface of the vascular smooth muscle cell, coupled to a therapeutic agent dosage form that inhibits a cellular activity of the muscle cell. Methods are also provided for the direct and/or targeted delivery of therapeutic agents to vascular smooth muscle cells that cause a dilation and fixation of the vascular lumen by inhibiting smooth muscle cell contraction, thereby constituting a biological stent.

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Номер записи: 20
30-08-2012 дата публикации

Immunologically modified carbon nanotubes for cancer treatment

Номер: US20120220921A1
Автор: Wei R. Chen
Принадлежит: University of Central Oklahoma

A method for constructing a compound of immunologically modified nanotubes and method for using the compound to deliver immunoadjuvants to tumor cells and to produce targeted, synergistic photophysical and immunological reactions for cancer treatment. To prepare the immunologically modified nanotubes, carbon nanotubes are dissolved in a solution of glycated chitosan, an immunostimulant, hence using glycated chitosan as a surfactant for rendering the aqueous solution of nanotubes stable. The compound can be used for treatment of cancer. The method includes steps of intratumorally administering immunologically modified nanotubes and administering laser irradiation of the target tumor. The nanotube serves as a carrier to deliver immunoadjuvants to the tumor cells and serves as a light-absorbing agent in a cell body of a tumor in a host. Upon laser irradiation of target tumor cells, immunologically modified nanotubes inside the tumor cells can produce spatially and temporally synchronized photothermal and immunological reactions for cancer treatment.

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Номер записи: 21
13-09-2012 дата публикации

Methods for fabricating polymer-bioceramic composite implantable medical devices

Номер: US20120228810A1
Автор: Bin Huang, David C. Gale
Принадлежит: Advanced Cardiovascular Systems Inc

Methods relating to polymer-bioceramic composite implantable medical devices are disclosed.

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Номер записи: 22
13-09-2012 дата публикации

Transmission gate-based spin-transfer torque memory unit

Номер: US20120230093A1
Автор: Hai Li, Hongyue Liu, Yang Li, Yiran Chen, Yong Lu
Принадлежит: SEAGATE TECHNOLOGY LLC

A transmission gate-based spin-transfer torque memory unit is described. The memory unit includes a magnetic tunnel junction data cell electrically coupled to a bit line and a source line. A NMOS transistor is in parallel electrical connection with a PMOS transistor and they are electrically connected with the source line and the magnetic tunnel junction data cell. The magnetic tunnel junction data cell is configured to switch between a high resistance state and a low resistance state by passing a polarized write current through the magnetic tunnel junction data cell. The PMOS transistor and the NMOS transistor are separately addressable so that a first write current in a first direction flows through the PMOS transistor and a second write current in a second direction flows through the NMOS transistor.

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Номер записи: 23
13-09-2012 дата публикации

Systems and methods for high-throughput detection of an analyte in a sample

Номер: US20120231960A1
Автор: Sebastian J. Osterfeld, Shan X. Wang
Принадлежит: MagArray Inc

Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use.

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Номер записи: 24
04-10-2012 дата публикации

Quantum and digital processor hybrid systems and methods to solve problems

Номер: US20120254586A1
Автор: Michael D. Coury, Mohammad Amin
Принадлежит: D Wave Systems Inc

Quantum processors and classical computers are employed together to solve computational problems. The classical computer may include a parameter learning module that produces a set of parameters. The quantum processor may be configured with the set of parameters to define a problem Hamiltonian and operated to perform adiabatic quantum computation and/or quantum annealing on the problem Hamiltonian to return a first solution to the problem. The parameter learning module of the classical computer may then be used to revise the set of parameters by performing a classical optimization, such as a classical heuristic optimization. The quantum processor may then be programmed with the revised set of parameters to return a revised solution to the problem. The quantum processor may include a superconducting quantum processor implementing superconducting flux qubits.

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Номер записи: 25
11-10-2012 дата публикации

Graphene electronic device and method of fabricating the same

Номер: US20120256167A1
Автор: Hee-jun Yang, Hyun-Jong Chung, Jin-Seong Heo, Sun-Ae Seo, Sung-Hoon Lee
Принадлежит: SAMSUNG ELECTRONICS CO LTD

The graphene electronic device may include a gate oxide on a conductive substrate, the conductive substrate configured to function as a gate electrode, a pair of first metals on the gate oxide, the pair of the first metals separate from each other, a graphene channel layer extending between the first metals and on the first metals, and a source electrode and a drain electrode on both edges of the graphene channel layer.

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Номер записи: 26
08-11-2012 дата публикации

Contacts for Nanowire Field Effect Transistors

Номер: US20120280205A1
Автор: Guy M. Cohen, Jeffrey W. Sleight, Sarunya Bangsaruntip, Shreesh Narasimha
Принадлежит: International Business Machines Corp

A nanowire field effect transistor (FET) device includes a channel region including a silicon nanowire portion having a first distal end extending from the channel region and a second distal end extending from the channel region, the silicon portion is partially surrounded by a gate stack disposed circumferentially around the silicon portion, a source region including the first distal end of the silicon nanowire portion, a drain region including the second distal end of the silicon nanowire portion, a metallic layer disposed on the source region and the drain region, a first conductive member contacting the metallic layer of the source region, and a second conductive member contacting the metallic layer of the drain region.

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Номер записи: 27
08-11-2012 дата публикации

Quantum dot white and colored light-emitting devices

Номер: US20120280611A1
Автор: Jason Heine, Jeffrey N. Miller, Klavs F. Jensen, Moungi G. Bawendi, Ronald L. Moon
Принадлежит: Massachusetts Institute of Technology, Philips Lumileds Lighing Co LLC

A light-emitting device comprising a population of quantum dots (QDs) embedded in a host matrix and a primary light source which causes the QDs to emit secondary light and a method of making such a device. The size distribution of the QDs is chosen to allow light of a particular color to be emitted therefrom. The light emitted from the device may be of either a pure (monochromatic) color, or a mixed (polychromatic) color, and may consist solely of light emitted from the QDs themselves, or of a mixture of light emitted from the QDs and light emitted from the primary source. The QDs desirably are composed of an undoped semiconductor such as CdSe, and may optionally be overcoated to increase photoluminescence.

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Номер записи: 28
15-11-2012 дата публикации

Spin current generator for stt-mram or other spintronics applications

Номер: US20120287704A1
Автор: Gurtej Sandhu, Jun Liu
Принадлежит: Micron Technology Inc

Spin current generators and systems and methods for employing spin current generators. A spin current generator may be configured to generate a spin current polarized in one direction, or a spin current selectively polarized in two directions. The spin current generator may by employed in spintronics applications, wherein a spin current is desired.

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Номер записи: 29
10-01-2013 дата публикации

Transparent bacterial cellulose nanocomposite hydrogels

Номер: US20130011385A1
Автор: Chandrakant J. Panchal, Wankei Wan, Xinsheng Li
Принадлежит: Axcelon Biopolymers Corp

A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or/and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength. The disclosed polymer nanocomposite hydrogel and compositions pertain to hydrogel applications, particularly contact lenses and optic components for biosensor.

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Номер записи: 30
31-01-2013 дата публикации

Lighting devices with prescribed colour emission

Номер: US20130026506A1
Автор: Hagai Arbell
Принадлежит: Yissum Research Development Co of Hebrew University of Jerusalem

Optical conversion layers based on semiconductor nanoparticles for use in lighting devices, and lighting devices including same. In various embodiments, spherical core/shell seeded nanoparticles (SNPs) or nanorod seeded nanoparticles (RSNPs) are used to form conversion layers with superior combinations of high optical density (OD), low re-absorbance and small FRET. In some embodiments, the SNPs or RSNPs form conversion layers without a host matrix. In some embodiments, the SNPs or RSNPs are embedded in a host matrix such as polymers or silicone. The conversion layers can be made extremely thin, while exhibiting the superior combinations of optical properties. Lighting devices including SNP or RSNP-based conversion layers exhibit energetically efficient superior prescribed colour emission

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Номер записи: 31
07-02-2013 дата публикации

Delivery of Hydrophilic Drugs

Номер: US20130034590A1
Автор: Aikaterini Lalatsa, Andreas Schatzlein, Ijeoma Uchegbu
Принадлежит: UNIVERSITY COLLEGE LONDON

Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.

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Номер записи: 32
07-02-2013 дата публикации

Dermatological compositions comprising avermectin nanocapsules

Номер: US20130034612A1
Автор: Claire Mallard, Lara Baudonnet
Принадлежит: GALDERMA SA

Compositions and nanoemulsions containing lipid nanocapsules dispersed in a hydrophilic phase, such nanocapsules including at least one avermectin compound, are useful for the treatment of dermatological pathologies, e.g., rosacea.

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Номер записи: 33
14-02-2013 дата публикации

Fluorescent silica-based nanoparticles

Номер: US20130039848A1
Автор: Andrew Burns, Hoosweng Ow, Jason Lewis, Michelle Bradbury, Oula Penate Medina, Steven Larson, Ulrich Wiesner
Принадлежит: CORNELL UNIVERSITY, SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

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Номер записи: 34
14-02-2013 дата публикации

Method of making polymer-bioceramic composite implantable medical devices

Номер: US20130041065A1
Автор: Bin Huang, David C. Gale, Garth L. Wilkes, Syed Faiyaz Ahmed Hossainy, Vincent J. Gueriguian, Yunbing Wang
Принадлежит: Advanced Cardiovascular Systems Inc

Methods and devices relating to polymer-bioceramic composite implantable medical devices are disclosed.

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Номер записи: 35
21-02-2013 дата публикации

Catalysts, Activating Agents, Support Media, and Related Methodologies Useful for Making Catalyst Systems Especially When the Catalyst is Deposited onto the Support Media Using Physical Vapor Deposition

Номер: US20130045155A1
Автор: Allen R. Siedle, Craig S. Chamberlain, Gina M. Buccellato, Larry A. Brey, Marvin E. Jones, Thomas E. Wood
Принадлежит: 3M Innovative Properties Co

Use of physical vapor deposition methodologies to deposit nanoscale gold on activating support media makes the use of catalytically active gold dramatically easier and opens the door to significant improvements associated with developing, making, and using gold-based, catalytic systems. The present invention, therefore, relates to novel features, ingredients, and formulations of gold-based, heterogeneous catalyst systems generally comprising nanoscale gold deposited onto a nanoporous support.

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Номер записи: 36
07-03-2013 дата публикации

Memory device and method for manufacturing the same

Номер: US20130058162A1
Автор: Susumu Shuto, Takaya Yamanaka
Принадлежит: Toshiba Corp

According to one embodiment, a memory device includes: a first signal line; a second signal line; a transistor; a memory region; and a conductive region. The transistor controls a conduction of each of a current in a first direction flowing between the first line and the second line and a current in a second direction opposite to the first direction. The memory region has a first magnetic tunnel junction element which is connected between the first line and one end of the transistor, a magnetization direction of which becomes parallel when a current not less than a first parallel threshold value flows in the first direction, and the magnetization direction of which becomes antiparallel when a current not less than a first antiparallel threshold value flows in the second direction. The conductive region is connected between the second line and the other end of the transistor.

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Номер записи: 37
14-03-2013 дата публикации

COPOLYMER-STABILIZED EMULSIONS

Номер: US20130064759A1
Автор: Chang Connie B., Deming Timothy J., Graves Sara M., Hanson Jarrod A., Mason Thomas G.
Принадлежит: The Regents of the University of California

An emulsion includes a substantially continuous liquid medium, and a plurality of droplet structures dispersed within the substantially continuous liquid medium. Each droplet structure of the plurality of droplet structures includes an outer droplet of a first liquid having an outer surface; an inner droplet of a second liquid within the first droplet, the second liquid being immiscible in the first liquid, wherein the inner and outer droplets have a boundary surface region therebetween; an outer layer of block copolymers disposed on the outer surface of the outer droplet; and an inner layer of block copolymers disposed on the boundary surface region between the outer and the inner droplets. 1. An emulsion , comprising:a substantially continuous liquid medium; anda plurality of droplet structures dispersed within said substantially continuous liquid medium,wherein each droplet structure of said plurality of droplet structures comprises:an outer droplet of a first liquid having an outer surface;an inner droplet of a second liquid having an inner surface within said first droplet, said second liquid being immiscible in said first liquid, wherein said inner and outer droplets have a film of said first liquid in a surface boundary region therebetween;an outer layer of block copolymers disposed on said outer surface of said outer droplet; andan inner layer of block copolymers disposed on said inner surface of said inner droplets in proximity to said boundary surface region between said outer and said inner droplets,wherein said block copolymers comprise a hydrophilic polymer block and a hydrophobic polymer block that act in combination to stabilize said droplet structure, and wherein said first liquid is immiscible in said substantially continuous liquid medium.2. An emulsion according to claim 1 , wherein said droplet structure has a maximum dimension corresponding to an undeformed droplet diameter that is less than about 1000 nm and greater than about 10 nm.3. An ...

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Номер записи: 38
14-03-2013 дата публикации

Novel cationic lipids and methods of use thereof

Номер: US20130064894A1
Автор: Alan Martin, James Heyes, Mark Wood
Принадлежит: PROTIVA BIOTHERAPEUTICS INC

The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

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Номер записи: 39
21-03-2013 дата публикации

DOPED-CARBON NANO-ARCHITECTURED STRUCTURES AND METHODS FOR FABRICATING SAME

Номер: US20130069011A1
Автор: Duong Binh Au Thanh, Gangopadhyay Palash, Thomas Jayan
Принадлежит: The Arizona Board of Regents on Behalf of the University of Arizona

In an exemplary method, a nano-architectured carbon structure is fabricated by forming a unit (e.g., a film) of a liquid carbon-containing starting material and at least one dopant. A surface of the unit is nano-molded using a durable mold that is pre-formed with a pattern of nano-concavities corresponding to a desired pattern of nano-features to be formed by the mold on the surface of the unit. After nano-molding the surface of the unit, the first unit is stabilized to render the unit and its formed nano-structures capable of surviving downstream steps. The mold is removed from the first surface to form a nano-molded surface of a carbonization precursor. The precursor is carbonized in an inert-gas atmosphere at a suitable high temperature to form a corresponding nano-architectured carbon structure. A principal use of the nano-architectured carbon structure is a carbon electrode used in, e.g., Li-ion batteries, supercapacitors, and battery-supercapacitor hybrid devices. 1. A method for fabricating a nano-architectured doped carbon structure , comprising:preparing a carbon-containing starting material including at least one dopant;nano-molding a surface of the starting material, using a durable mold pre-formed with a pattern of nano-concavities corresponding to a desired pattern of nano-features to be formed by the mold on the surface, by bringing together the surface of the starting material and the pattern of nano-concavities;when the nano-features formed by the mold on the surface of the starting material have reached at least a threshold level of self-supportability, separating the mold and surface of the unit from each other to form a carbonization precursor having a nano-molded surface; andcarbonizing the precursor to form a corresponding nano-architectured carbon structure.2. The method of claim 1 , wherein the dopant comprises a substance selected from a group consisting of metals and semiconductors.3. The method of claim 2 , wherein the dopant comprises nano ...

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Номер записи: 40
21-03-2013 дата публикации

DOWN CONVERSION

Номер: US20130070443A1
Автор: Eberle Thomas, Pan Junyou, Schulte Niels
Принадлежит:

The present invention relates inter alia to an array comprising i times j array elements, wherein the array elements may comprise at least one quantum dot and/or at least one photoluminescent compound. Further the present invention relates to devices comprising these arrays. The arrays and devices can be used to generate white light with high color purity. 122-. (canceled)23. An array Acomprising i times j array elements a , wherein said array Acomprises at least one composition comprising at least one quantum dot being localized in one or more of the array elements a , and wherein i is a row index and j is a column index being larger than 0 , with the proviso that if i=j=1 , the composition of array element acomprises at least two quantum dots and at least one photoluminescent compound.24. The array of claim 23 , wherein the compositions comprised by the array comprise at least one further photoluminescent compound.25. The array of claim 23 , wherein the shape of the array elements ais square claim 23 , circular claim 23 , oval claim 23 , triangular claim 23 , hexagonal claim 23 , polygonal and irregular curved.26. The array of claim 23 , wherein less than 20% of the array elements aare transparent and do not comprise a composition comprising a quantum dot and/or a photoluminescent compound.27. The array of claim 23 , wherein said array comprises at least 2 quantum dots.28. The array of claim 23 , wherein said at least one quantum dot has an emission intensity maximum in the range between 380 and 700 nm.29. The array of claim 23 , wherein if said composition comprises more than one quantum dot claim 23 , said quantum dots differ in their emission intensity maxima.30. The array of claim 23 , wherein if said composition comprises more than one quantum dot claim 23 , quantum dots showing a re-absortion rate of at least 5% are separated in different array elements.31. The array of claim 23 , wherein said at least one quantum dot is selected from Group II-VI claim 23 , ...

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Номер записи: 41
21-03-2013 дата публикации

Fenugreek Seed Extract to Lower Blood Cholesterol

Номер: US20130071470A1
Автор: Aburdeineh Hikmat George, Aburdeineh S. George
Принадлежит:

A method of lowering blood cholesterol in a non-diabetic patient by at least 30% is described. The method involves orally administering for 30 consecutive days a fenugreek seed extract composition. Various methods of preparation and various formulations are described. Physiologically effective pharmaceutical compositions and beverages containing fenugreek seed extracts and other active components are also disclosed. 1Trigonella foenum graecum. A composition consisting essentially of fenugreek () seed extract.2. The composition of claim 1 , wherein the composition is selected from the group consisting of a pill claim 1 , capsule claim 1 , granules claim 1 , microparticles claim 1 , nanoparticles and liposomes.3. The composition of claim 1 , wherein the composition is formulated for oral delivery in an oral dosage form.4. The composition of claim 1 , wherein the composition optionally includes an agent selected from the group consisting of a pharmaceutically acceptable excipient claim 1 , lubricant claim 1 , binder claim 1 , glidant claim 1 , filler claim 1 , flavoring agent claim 1 , masking agent claim 1 , vitamin claim 1 , mineral claim 1 , a carrier and mixtures thereof.5. The composition of claim 3 , wherein the composition is in oral dosage form in single dosage.6. The composition of claim 5 , wherein the composition is oral dosage form in a single dose enteric coated formulation.7. The composition of claim 1 , wherein the oral dosage form is a liquid oral formulation.8. The composition of claim 7 , wherein the liquid oral formulation is a liposomal formulation.9. The composition of claim 3 , wherein the oral dosage from contains a plurality of therapeutic nanoparticles.10. The composition of claim 1 , wherein the extract is contained in a package with instructions for use. This application is a continuation application of U.S. application Ser. No. 11/030,886 filed Jan. 10, 2005, now pending; which claims the benefit under 35 USC §119(e) to U.S. Application Ser. ...

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Номер записи: 42
21-03-2013 дата публикации

Fascile synthesis of biocompatible polymer capsule nanoparticles for drug encapsulation

Номер: US20130071472A1
Автор: SHIEH Dar-Bin
Принадлежит:

The present invention relates to a method for preparing a capsule nanoparticle used in encapsulating hydrophobic medicines, comprising the following steps: (A) providing a biocompatible polymer and an organic solution containing a hydrophobic medicine; (B) stirring the organic solution at 3-10° C., and titrating with an alcohol solution, so as to make the biocompatible polymer encapsulate hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at 3-10° C.; (D) filtering the capsule nanoparticle to an average size controllable in the range of 60-450 nm; and (E) lyophilizing the encapsulated particles. 1. A method for preparing capsules encapsulating hydrophobic medicines , comprising the steps of:(A) providing an organic solution having a biocompatible polymer and a hydrophobic medicine;(B) stirring the organic solution at a low temperature of 3 to 10° C., and titrating with a alcohol solution, to make the biocompatible polymer encapsulate the hydrophobic medicine to form a capsule nanoparticle;(C) ultrasonic vibrating the capsule nanoparticle at a low temperature of 3 to 10° C.;(D) filtering the capsule nanoparticle, to make an average capsule nanoparticle diameter of the capsule nanoparticle at 60-450 nm; and(E) lyophilizing the capsule nanoparticle.2. The method for preparing capsules encapsulating hydrophobic medicines according to claim 1 , wherein claim 1 , the biocompatible polymer is selected from the group consisting of: (poly-(D claim 1 ,L-lactide-co-glycolide)) claim 1 , PLA claim 1 , and PEG-PLA.3. The method for preparing capsules encapsulating hydrophobic medicines according to claim 1 , wherein the hydrophobic medicine is a anti-cancer medicine.4. The method for preparing capsules encapsulating hydrophobic medicines according to claim 3 , wherein claim 3 , the anti-cancer is at least selected from the group consisting of: phyxol claim 3 , J-30 claim 3 , LY 294002 and AG490.5. The method for preparing ...

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Номер записи: 43
21-03-2013 дата публикации

Systems and methods for detecting biomarkers of interest

Номер: US20130071839A1
Автор: Barry Lutz, Georg Seelig
Принадлежит: Individual

In some embodiments, a strand displacement system is provided. Such a system may include a first nucleic acid catalyst molecule; a nucleic acid gate molecule, wherein the first nucleic acid catalyst molecule binds the nucleic acid gate molecule forming a nucleic acid gate-catalyst complex and releases an output molecule; and a nucleic acid sink molecule. The nucleic acid sink molecule sequesters a putative second nucleic acid catalyst, wherein the second nucleic acid catalyst differs from the first nucleic acid catalyst molecule by at least one nucleotide. In some aspects, the first nucleic acid catalyst may include a biomarker of interest or a nucleic acid aptamer which binds an amino acid-based biomarker of interest.

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Номер записи: 44
28-03-2013 дата публикации

Photo-Switchable Fullerene-Based Materials as Interfacial Layers in Organic Photovoltaics

Номер: US20130074920A1
Автор: Danisha M. Rivera-Nazario, Luis Echegoyen, Michael D. Irwin
Принадлежит: University of Texas System

Design and use of photo-switching, fullerene-based dyads of the design x-D-y-A or D-y-A-x as interfacial layers (IFL) for organic photovoltaic (OPV) devices are described herein. The fullerene-based dyads and triads of the present invention contain electron-donating substituents such as porphyrins or phthalocyanines that exhibit charge separation states with long lifetimes upon irradiation, resulting in rejection of electrons reaching the electrode and concurrently promoting the conduction of holes. This phenomenon has a strong rectifying effect on the whole device, not just the interfaces, resulting in improved charge extraction from the interior of the photo-active layer. The invention further describes anchoring an IFL to the ITO surface as a monolayer, bilayer, or greater multilayers. One OPV design embodiment of the present invention embodiment involves the formation of covalent bonds via silane groups (—SiR 3 ) as the anchor (x), to form siloxane bonds.

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Номер записи: 45
28-03-2013 дата публикации

METHOD FOR PRODUCING ZINC-OXIDE NANOSTRUCTURE ELECTRODES, AND METHOD FOR PRODUCING DYE-SENSITIZED SOLAR CELLS USING SAME

Номер: US20130074923A1
Автор: Jung Gun-Young, KIM Jin-Ju, Kim Ki-Seok
Принадлежит: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

Provided are a method of preparing a zinc oxide nanostructure electrode and a method of preparing a dye-sensitized solar cell using the same. According to the present invention, the method of preparing a zinc oxide nanostructure electrode may include sequentially forming a superhydrophobic self-assembled layer and a zinc layer on a carrier substrate having a stamp pattern included therein, disposing the zinc layer on the carrier to face a first substrate and performing a stamp method to form at least one zinc pattern on the first substrate, oxidizing the zinc pattern to form zinc oxide seeds, and growing at least one zinc oxide nanostructure from the zinc oxide seeds by using a hydrothermal synthesis method to form a zinc oxide nanostructure electrode composed of the at least one zinc oxide nanostructure. 1. A method of preparing a zinc oxide nanostructure electrode , the method comprising:sequentially forming a superhydrophobic self-assembled layer and a zinc layer on a carrier substrate having a stamp pattern included therein;disposing the zinc layer on the carrier to face a first substrate and performing a stamp method to form at least one zinc pattern on the first substrate;oxidizing the zinc pattern to form zinc oxide seeds; andgrowing at least one zinc oxide nanostructure from the zinc oxide seeds by using a hydrothermal synthesis method to form a zinc oxide nanostructure electrode composed of the at least one zinc oxide nanostructure.2. The method of claim 1 , wherein the first substrate comprises a transparent flexible substrate and a transparent conductive layer disposed on a surface of the flexible substrate claim 1 , and the zinc pattern is disposed on the transparent conductive layer.3. The method of claim 2 , wherein the transparent flexible substrate is any one of an ultra-thin glass substrate claim 2 , a polyethylene terephthalate (PET) substrate claim 2 , a polycarbonate (PC) substrate claim 2 , a polyether sulfone (PES) substrate claim 2 , a ...

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Номер записи: 46
28-03-2013 дата публикации

PROCESS FOR DISPERSING NANOCATALYSTS INTO PETROLEUM-BEARING FORMATIONS

Номер: US20130075092A1
Автор: Langdon John E., Ware Charles H.
Принадлежит: WORLD ENERGY SYSTEMS, INC.

Embodiments include methods for recovering petroleum products from a formation containing heavy crude oil. In one embodiment, a method includes positioning a steam generator within the petroleum-bearing formation, flowing a fuel source and an oxidizing agent into the steam generator, generating and releasing steam from the steam generator to heat the heavy crude oil, flowing a catalytic material containing a nanocatalyst into the petroleum-bearing formation, and exposing the catalytic material to the heavy crude oil. The method further provides forming lighter oil products from the heavy crude oil within the petroleum-bearing formation and extracting the lighter oil products from the petroleum-bearing formation. In some examples, the fuel source contains methane, syngas, or hydrogen gas, and the oxidizing agent contains oxygen gas, air, or oxygen enriched air. The nanocatalyst may contain cobalt, iron, nickel, molybdenum, chromium, tungsten, titanium, alloys thereof, or combinations thereof. 1. A method for recovering hydrocarbons from a reservoir , comprising:flowing a nanocatalyst into the reservoir using a carrier gas, wherein the carrier gas comprises at least one of carbon dioxide and nitrogen;flowing steam into the reservoir using a steam generator;heating the nanocatalyst and hydrocarbons using steam;reducing the viscosity of hydrocarbons in the reservoir using a viscosity reducing gas; andrecovering hydrocarbons from the reservoir.2. The method of claim 1 , further comprising positioning the steam generator in a wellbore in communication with the reservoir claim 1 , and generating steam using the steam generator for flowing into the reservoir.3. The method of claim 2 , further comprising injecting the nanocatalyst downstream from the steam generator and into the steam generated by the steam generator for flowing into the reservoir.4. The method of claim 3 , further comprising flowing a fuel and an oxidant into the steam generator claim 3 , and combusting the ...

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Номер записи: 47
28-03-2013 дата публикации

FLUORESCENT POWDER OF HALOGEN SILICATE CONTAINING NANO-METAL PARTICLES AND PREPARATION METHOD THEREOF

Номер: US20130075658A1
Автор: Liu Jun, Ma Wenbo, Zhou Mingjie
Принадлежит:

Provided is a fluorescent powder of halogen-silicate containing nano-metal particles with the formula of CaX.y(CaEuMnO).SiO:zM, wherein X is fluorin or/and chlorine, y is 1 or 2, z is molar ratio of nano-metal particles and fluorescent powder CaX.y(CaEuMnO).SiO, 0 Подробнее

Номер записи: 48
28-03-2013 дата публикации

Ammonia Nanosensors, and Environmental Control System

Номер: US20130075690A1
Автор: BRIMAN Mikhail, Bryant Craig, Chang Ying-Lan, Gabriel Jean-Christophe P., Gandhi Shripal C., Johnson Bradley N., Ouborg Willem-Jan, Passmore John Loren, Ramakrishnan Kastooriranganathan, Skarupo Sergei, STAR ALEXANDER, Valcke Christian
Принадлежит: Nanomix, Inc.

Embodiments of nanoelectronic sensors are described, including sensors for detecting analytes such ammonia. An environmental control system employing nanoelectronic sensors is described. A personnel safety system configured as a disposable badge employing nanoelectronic sensors is described. A method of dynamic sampling and exposure of a sensor providing a number of operational advantages is described. 1. A nanostructure sensor for sensing an analyte of interest in a sample , comprising:a substrate;a nanostructured element disposed adjacent the substrate;one or more conducting elements in electrical communication with the first nanostructure; andat least one functionalization operatively associated with the nanostructured element, the at least one functionalization configured to provide sensitivity for the analyte of interest.2. A sensor as in claim 1 , wherein the nanostructured element includes a network of carbon nanotubes disposed adjacent the substrate.3. A sensor as in claim 2 , wherein the analyte of interest includes ammonia.4. A sensor as in claim 2 , wherein the at least one functionalization includes an organic recognition material.5. A sensor as in claim 4 , wherein the organic recognition material includes a polymer.6. A sensor as in claim 5 , wherein the polymer includes at least one of a conductive polymer and a semi-conductive polymer.7. A sensor as in claim 4 , wherein the organic recognition material includes PABS.8. A sensor as in claim 4 , wherein the organic recognition material includes a nonionic surfactant.9. A sensor as in claim 4 , wherein the organic recognition material includes glycerol.10. A sensor as in claim 4 , wherein the network includes at least one SWNTs which is stably associated with the organic recognition material prior to formation of the network.11. A sensor as in claim 2 , wherein the at least one functionalization includes an inorganic recognition material.12. A sensor as in claim 2 , wherein the one or more conducting ...

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Номер записи: 49
28-03-2013 дата публикации

Hybrid powder of halloysite nanotube and light-scattering nanoparticle, method for preparing the same, and uvscreening cosmetic composition containing the same as active ingredient

Номер: US20130078293A1
Автор: Dae Sup Kil, Myung Eun Ju, Sung Wook Cho, Yong Jae Suh
Принадлежит: Individual

The present invention provides a hybrid powder of halloysite nanotubes and light-scattering nanoparticles, a method for preparing the same, and a UV-screening cosmetic composition containing the same as an active ingredient. The hybrid powder of halloysite nanotubes and light-scattering nanoparticles according to the present invention, in which the light-scattering nanoparticles are loaded into the halloysite nanotubes, can prevent the light-scattering nanoparticles from penetrating the skin, which minimizes side effects, and has excellent UV-screening effect. Thus, the hybrid powder of halloysite nanotubes and light-scattering nanoparticles according to the present invention can be effectively used as a UV-screening cosmetic composition.

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Номер записи: 50
28-03-2013 дата публикации

SKIN ANTIAGING TREATMENT

Номер: US20130078295A1
Автор: Almiñana Domenech Nuria, Cebrian Puche Juan, Delgado Gonzalez Raquel
Принадлежит: LIPOTEC S.A.

A method for skin antiaging treatment including administering Botulinum toxin to an area of facial and/or neck skin, combined with the administration of a cosmetic or pharmaceutical composition having a cosmetically or pharmaceutically effective amount of at least one peptide derived from the SNAP-25 protein and/or at least one enkephalin-derived peptide, and at least one cosmetically or pharmaceutically acceptable excipient or adjuvant. 1. A method for skin antiaging treatment comprising:a. The administration of an effective amount of Botulinum toxin to an area of facial and/or neck skin, [{'br': None, 'sub': 1', '2, 'R-AA-R\u2003\u2003(I)'}, 'its stereoisomers, mixtures thereof, and/or its cosmetically or pharmaceutically acceptable salts thereof, in which AA is a sequence selected from the group consisting of SEQ ID No.11, SEQ ID No.4, or a sequence of 7 to 12 adjacent amino acids contained in SEQ ID No.4, wherein said sequence comprises the amino acid sequence of SEQ ID No.11;', 'wherein:', {'sub': 1', '5, 'Ris selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl, substituted or non-substituted aralkyl and R—C(O)—; and'}, {'sub': 2', '3', '4', '3', '3', '3', '4, 'Ris selected from the group consisting of —NRR, —ORand —SR; where Rand Rare independently selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, substituted or non-substituted heterocyclyl, substituted or non-substituted heteroarylalkyl, substituted or non-substituted aryl and substituted or non-substituted aralkyl;'}, {'sub': '5', 'wherein Ris selected from the group consisting of H, substituted or non-substituted non-cyclic aliphatic group, substituted or non-substituted alicyclyl, substituted or non- ...

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Номер записи: 51
28-03-2013 дата публикации

Novel quinacridone pigment composition, and method for producing quinacridone microparticles

Номер: US20130078467A1
Автор: Daisuke Honda, Masakazu Enomura, Masaki Maekawa
Принадлежит: M Technique Co Ltd

A quinacridone pigment composition contains quinacridone microparticles which have durability and spectral characteristics equivalent to those required for a magenta color of a dye. The quinacridone pigment composition contains at least one type of quinacridone microparticles, wherein a difference between the maximum transmittance (Tmax1) and the minimum transmittance (Tmin) is 80% or more in a transmission spectrum at 350 nm to 800 nm and the difference between the maximum and minimum transmittance is 30% or more in a transmission spectrum at 350 nm to 580 nm, or the difference between the maximum transmittance (Tmax1) and the minimum transmittance (Tmin) is 80% or more in a transmission spectrum at 350 nm to 800 nm and the wavelength (λmax) at which the transmittance in a transmission spectrum at 350 nm to 500 nm becomes maximum is less than 430 nm. A method is provided for producing the quinacridone microparticles.

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Номер записи: 52
28-03-2013 дата публикации

Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro

Номер: US20130079382A1
Автор: Smith Larry J.
Принадлежит:

Compositions and methods for down modulating target gene expression with RNA interference, as well as methods for administering said compositions are disclosed. The method comprises administering a first strand to a cell, incubating the cell for a time period suitable for uptake of the first oligo prior to administering a second strand, wherein the first strand and said second strand form an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA. 138-. (canceled)39. A method of inhibiting expression of a gene target comprising contacting a cell expressing said gene target with an effective amount of a nucleic acid compound , said compound being effective to degrade mRNA or inhibit translation of mRNA encoding a protein produced by said gene target , wherein said compound comprises two complementary strands , said method comprisinga) administering a first strand to said cell,b) incubating said cell for a time period suitable for uptake of said first oligo into said cell, andc) administering a second strand to said cell, said first strand and said second strand forming an intracellular duplex which is effective to catalyze degradation of gene target mRNA or inhibit translation of said mRNA.40. The method of claim 39 , wherein step c) is carried out between about 4 and about 48 hours after step a).41. The method of claim 39 , wherein said compound is effective to inhibit the expression of a gene listed in Table 2.42. The method of claim 39 , wherein said oligo comprises at least one modified backbone linkage selected from the group consisting of phosphorothioate linkages claim 39 , methylphosphonate linkages claim 39 , ethylphosphonate linkages claim 39 , boranophosphate linkages claim 39 , sulfonamide claim 39 , carbonylamide claim 39 , phosphorodiamidate claim 39 , phosphorodiamidate linkages comprising a positively charged side group claim 39 , phosphorodithioates claim 39 , aminoethylglycine claim 39 ...

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Номер записи: 53
04-04-2013 дата публикации

ANTIBACTERIAL NANOFIBER

Номер: US20130082424A1
Автор: Iizuka Mami, Imashiro Yasuo, Ogushi Yukiko, Sasaki Naokazu
Принадлежит: NISSHINBO INDUSTRIES, INC.

Disclosed is an antibacterial nanofiber which comprises a polymer having an electron-withdrawing group and/or an electron-withdrawing atomic group and has an average fiber diameter of not less than 1 nm and less than 1000 nm, wherein the ratio of the binding energy of the minimum unit of the polymer at 25° C. to the binding energy of the electron-withdrawing group and/or the electron-withdrawing atomic group contained in the minimum unit of the polymer at 25° C. is 0.13 or greater. The nanofiber has an antibacterial activity by itself, and therefore can exhibit an antibacterial activity without the need of adding any antibacterial agent. 1. A method of imparting an antibacterial activity to a nanofiber , comprising:spinning a polymer possessing electron-withdrawing groups and/or electron-withdrawing atomic groups, wherein the polymer has a ratio of the bond energy at 25° C. of electron-withdrawing groups and/or electron-withdrawing atomic groups present in a smallest unit of the polymer to the bond energy at 25° C. of the smallest unit of the polymer of at least 0.13, andobtaining a nanofiber having an average fiber diameter of at least 1 nm but less than 1,000 nm,said nanofiber itself exhibiting an antibacterial activity.2. The method of wherein claim 1 , in surface functional group measurement using an acid-base titration method claim 1 , the ratio of functional groups in a specific weight of the nanofiber to functional groups in a film of the same weight that is formed of the polymer is at least 1.3.3. The method of or wherein the nanofiber is composed solely of the polymer having electron-withdrawing groups and/or electron-withdrawing atomic groups.4. The method of claim 1 , wherein the polymer is a polyester resin claim 1 , a polyamide resin claim 1 , a polyurethane resin claim 1 , a polyacrylonitrile resin claim 1 , a polyamideimide resin claim 1 , a polyvinyl chloride resin or a polystyrene resin.5. The method of claim 4 , wherein the polymer is a water- ...

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Номер записи: 54
04-04-2013 дата публикации

METHOD OF MAKING NANOMATERIAL AND METHOD OF FABRICATING SECONDARY BATTERY USING THE SAME

Номер: US20130084238A1
Автор: Cho Jae-Phil, Lee Jung-In, Park Soo-Jin, Song Hyun-Kon
Принадлежит: UNIST Academy-Industry Research Corporation

Disclosed are a method of making a nanomaterial and a method of fabricating a lithium secondary battery using the same. The method of making a nanomaterial includes preparing a mixed solution including a metal salt aqueous solution and an alkylamine, and hydrothermally treating the mixed solution. 1. A method of making a nanomaterial comprising:preparing a mixed solution comprising a metal salt aqueous solution and an alkylamine; andhydrothermally treating the mixed solution.2. The method of making a nanomaterial of claim 1 , wherein the metal salt comprises a chloride claim 1 , a sulfate claim 1 , a nitrate claim 1 , and a combination thereof.3. The method of making a nanomaterial of claim 1 , wherein the metal salt comprises a copper salt claim 1 , a nickel salt claim 1 , a lead salt claim 1 , or a combination thereof.4. The method of making a nanomaterial of claim 3 , wherein the metal salt comprises copper chloride (CuCl) claim 3 , copper sulfate (CuSO) claim 3 , or a combination thereof.5. The method of making a nanomaterial of claim 1 , wherein the metal salt and the alkylamine in the mixed solution are present in a mole ratio of about 3:1 to about 15:1.6. The method of making a nanomaterial of claim 1 , wherein the alkylamine comprises a compound represented by the following Chemical Formula 1 claim 1 , a compound represented by the following Chemical Formula 2 claim 1 , or a combination thereof:{'br': None, 'sub': 3', '2', 'm', '2, 'CH(CH)NH\u2003\u2003[Chemical Formula 1]'}{'br': None, 'sub': 2', '2', 'n', '2, 'NH(CH)NH\u2003\u2003[Chemical Formula 2]'}wherein, in the above Chemical Formula 1, m is an integer ranging from 7 to 20, and in the above Chemical Formula 2, n is an integer ranging from 4 to 20.7. The method of making a nanomaterial of claim 6 , wherein the alkylamine comprises decylamine claim 6 , dodecylamine claim 6 , tetradecylamine claim 6 , hexadecylamine claim 6 , octadecylamine claim 6 , or a combination thereof.8. The method of making a ...

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Номер записи: 55
04-04-2013 дата публикации

OLEOPHILIC ANTIMICROBIAL COMPOSITION

Номер: US20130084321A1
Автор: Park Chung Kwon
Принадлежит:

The present invention relates to an oleophilic antimicrobial composition comprising silica nanotubes containing silver nanoparticles. The composition is added to an oil-based composition, such as an oil-based paint, a ceramic composition or a fiber coating compositions, immediately before the use of the oil-based composition, such that the contact time of the silver nanoparticles with the organic solvent contained in the oil-based composition is shortened to inhibit the oxidation of the silver nanoparticles. In addition, the composition has improved antimicrobial effects due to the excellent dispersibility of the silver nanoparticles, because the silver nanoparticles do not agglomerate in any solvent due to the silica nanotube structures, unlike spherical silica structures. 1. An oleophilic antimicrobial composition wherein silica nanotubes containing silver nanoparticles are dispersed in an organic solvent.2. The oleophilic antimicrobial composition of claim 1 , wherein the silica nanotubes have fine pores formed therein claim 1 , each of the fine pores having a size of 30-50 nm and each of the silica nanotubes having a total length of 1-30 μm.3. The oleophilic antimicrobial composition of claim 2 , wherein the content of the silver nanoparticles in the silica nanotubes is 20000˜100000 ppm.4. The oleophilic antimicrobial composition of claim 3 , wherein the silica nanotubes are contained in an amount of 35-45 parts by weight based on 100 parts by weight of the organic solvent.5. The oleophilic antimicrobial composition of claim 4 , wherein the organic solvent is at least one selected from the group consisting of propylene glycol methyl ether acetate (hereinafter claim 4 , referred to as ‘PMA’) claim 4 , butyl cabitol claim 4 , butyl acetate and ethyl acetate.6. The oleophilic antimicrobial composition of claim 5 , wherein the oleophilic antimicrobial composition further contains a wetting/dispersing agent in an amount of 20-30 parts by weight based on 100 parts by ...

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Номер записи: 56
04-04-2013 дата публикации

NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS

Номер: US20130084569A1
Автор: Balasubramanian Shankar, Kagan Daniel, Manesh Kalayil Manian, Wang Joseph, Wu Jie
Принадлежит:

Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine. 1. A method of detecting biomolecular interactions based on a motion of a nanomachine , the method comprising:functionalizing a nanomachine with a capture probe adapted to interact with biological targets; anddetecting a presence of the biological targets in an environment based on a motion of the nanomachine.2. The method of claim 1 , wherein detecting the presence of the biological targets comprises detecting a concentration of the biological targets based on a distance traveled by the functionalized nanomachine.3. The method of claim 1 , wherein detecting the presence of the biological targets in an environment comprises:providing the functionalized nanomachine and nanoparticle tags in the environment to allow the capture probe to form a complex with the nanoparticle tags and the biological targets; anddetecting the complex formation based on the motion of the functionalized nanomachine.4. The method of claim 1 , wherein detecting the complex formation comprises:detecting the motion of the functionalized nanomachine in a nanoparticle-releasing solution, wherein the presence of the released nanoparticle speeds up the motion of the functionalized nanomachine.5. The method of claim 1 , wherein the nanoparticle tags comprise silver nanoparticle tags.6. The method of claim 1 , wherein the nanomachine comprises an anode segment and a cathode segment.7. The method of claim 6 , wherein the anode segment comprises platinum and the cathode comprises gold.8. The method of comprising:wherein the biological targets comprise nucleic acid targets.9. The method of ...

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Номер записи: 57
04-04-2013 дата публикации

SCAFFOLD FOR ARTICULAR CARTILAGE REGENERATION AND METHOD FOR MANUFACTURING SAME

Номер: US20130084636A1
Автор: Cho Michael
Принадлежит: TE BIOS CO., LTD

Disclosed are scaffolds for regeneration of articular cartilage which are applicable to both the superficial zone and the middle zone of articular cartilage, and a method for manufacturing the same. The scaffolds have sufficient mechanical properties to support the implantation and regeneration of chondrocytes, and allow cells to show high cell viability with a high content of sulfated glycosaminoglycans (GAGs). In addition, being applicable to both the superficial zone and the middle zone of articular cartilage, the scaffolds facilitate cell adhesion and provide biomimetic surface environments that are effective for growing and differentiating stem cells. Therefore, the scaffolds are helpful in regenerating damaged articular cartilage, thus finding applications in stem cell therapy for articular cartilage damage and disease. Also, the application of the scaffolds can be extended to prostheses of the ear and the nose in plastic surgery. 1. A scaffold for regeneration of articular cartilage , comprising collagen gel consisting of a multiwalled carbon nanotube-incorporated 3-D collagen type II-based hydrogel seeded with either human mesenchymal stem cells , or chondrocytes or osteocytes that are differentiated from human mesenchymal stem cells.2. The scaffold of claim 1 , wherein human mesenchymal stem cells are derived from bone marrow.3. A method for manufacturing the scaffold of claim 1 , comprising:1) preparing a multiwalled carbon nanotube-phosphate buffered saline mixture by primarily ultrasonicating a mixture of multiwall carbon nanotubes, sulfuric acid, and nitric acid for 30˜100 min at 30˜70° C., neutralizing the mixture, centrifuging the mixture to collect the multiwalled carbon nanotubes, removing the solvents used, washing the multiwalled carbon nanotubes, secondarily ultrasonicating, recovering the multiwalled carbon nanotubes through centrifugation, and resuspending and dispersing the multiwalled nanotubes in phosphate buffered saline;2) mixing 70% of ...

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Номер записи: 58
04-04-2013 дата публикации

USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS

Номер: US20130084643A1
Автор: Aubertin Fabrice, Commarieu Annie, Crowther Nicolas, Louis Cédric, MARTINI Matteo, Perriat Pascal, Tillement Olivier
Принадлежит: TOTAL SA

The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well. 1. A method of study of a solid medium (i.e. an oil reservoir) by diffusion of a fluid through said solid medium , comprising: having average dimensions comprised, in preferred ascending order, between 20 and 200 nm, 20 and 100 nm, 50 and 100 nm, 60 and 80 nm;', 'detectable by means of one or several S signals at dilutions of less than or equal to 10;', 'adapted to form a stable colloidal suspension in a saline medium;', 'at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component., 'injecting, in this solid medium (diffusion), a liquid (injection liquid) comprising a nanoparticle-based tracer;'}recovering the liquid having diffused;analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.2. A method according to claim 1 , wherein the core of the nanoparticles contains:at least one material selected from the group consisting of: the semiconductors, noble metals, fluorides, vanadates or rare earth oxides and their mixtures and/or alloys; i. luminescent entities selected from the group consisting of: the semiconductors, oxides, rare earth fluorides or vanadates, organic fluorescent molecules, transition metal ions, rare earth ions connected, or not, to complexing molecules and/or to molecules allowing for enhancing their absorption and their mixtures and/or alloys;', 'ii. optionally, other entities allowing for modifying the luminescence properties and selected from the group consisting of: noble metal particles and their mixtures and/or alloys;', 'iii. and mixtures of (i) and (ii)., 'or a matrix selected from the group of materials consisting of: ...

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Номер записи: 59
11-04-2013 дата публикации

HETERONUCLEAR RADIOISOTOPE NANOPARTICLE OF CORE-SHELL STRUCTURE AND PREPARATION METHOD THEREOF

Номер: US20130087748A1
Автор: CHOI Seong-Ho, Jung Jin-Hyuck, Jung Sung-Hee, Kim Jong-bum, Moon Jinho
Принадлежит: KOREA ATOMIC ENERGY RESERACH INSTITUTE

Heteronuclear radioisotope nanoparticle of core-shell structure and a preparation method thereof are provided. The Heteronuclear radioisotope nanoparticle of core-shell structure comprising core of two different radioisotopes selected from a group consisting of Au, Ni, Ag, Cu, Co, Ir and Pd, and a shell comprising Si0surrounding the core. 1. A Heteronuclear radioisotope nanoparticle of core-shell structure , comprising a core comprising two different radioisotopes selected from a group consisting of Au , Ni , Ag , Cu , Co , Ir and Pd , and a shell comprising SiOsurrounding the core.2. The heteronuclear radioisotope nanoparticle of core-shell structure as set forth in claim 1 , wherein the core comprise a combination of Au and one of the rest of the group except Au.3. The heteronuclear radioisotope nanoparticle of core-shell structure as set forth in claim 1 , wherein the two different radioisotepes of the core emit radiations distinguished from each other.4. A method for preparing the heteronuclear radioisotope nanoparticle of core-shell structure as set forth in claim 1 , the method comprising:(step 1) preparing cores of the heteronuclear nanoparticle by dispersing two different types of atoms selected from a group consisting of Au, Ni, Ag, Cu, Co, Ir and Pd in water, and stabilizing the result with colloid stabilizer;{'sub': '2', '(step 2) preparing nanoparticle with core-shell structure by coating the nanoparticle core prepared at step 1 with SiOrepeatedly for several times;'}(step 3) removing the colloid stabilizer remaining in the core-shell structure prepared at step 2 by calcining the prepared nanoparticle; and(step 4) activating the nanoparticle within the core by irradiating neutron onto the nanoparticle with the core-shell structure prepared at step 3.5. The method as set forth in claim 4 , comprising applying the colloid stabilizer to the nanoparticle by irradiating radiation to stabilize the nanoparticle core of step 1.6. The method as set forth in claim ...

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Номер записи: 60
11-04-2013 дата публикации

CARBON NANOTUBE LIGHT EMITTING DEVICE, LIGHT SOURCE, AND PHOTO COUPLER

Номер: US20130087758A1
Автор: MAKI Hideyuki, Yamauchi Youhei
Принадлежит: KEIO UNIVERSITY

A plurality of electrodes, and carbon nanotubes disposed between the electrodes, at least part of the carbon nanotubes including a metal carbon nanotube are provided. The metal carbon nanotube generates heat upon passing of current to the electrodes and emits light by blackbody radiation, so that the emitted light has a wide emission wavelength region and can be modulated at high speed. This makes it possible to implement a continuum spectrum light source that can be modulated at high speed, which is suitable for use in information communication, electrical and electronic fields. 18-. (canceled)9. A carbon nanotube light emitting device , comprising:a plurality of electrodes;carbon nanotubes disposed between the electrodes, at least part of the carbon nanotubes including a metal carbon nanotube, andan insulator covering at least a surface of the metal carbon nanotube, whereinthe metal carbon nanotube generates heat upon passing of current to the electrodes and emits light by blackbody radiation, so that the emitted light can be modulated.10. A carbon nanotube light emitting device , comprising:a plurality of electrodes; andcarbon nanotubes disposed between the electrodes, at least part of the carbon nanotubes including a metal carbon nanotube, whereinthe carbon nanotube is held in vacuum and generates heat upon passing of current to the electrodes and emits light by blackbody radiation, so that the emitted light can be modulated.11. The carbon nanotube light emitting device according to claim 9 , wherein the metal carbon nanotube and the electrodes are disposed on a substrate.12. A light source claim 9 , comprising the carbon nanotube light emitting device according to .13. The light source according to claim 12 , wherein the metal carbon nanotube is disposed on a transparent substrate so as to be orthogonal to an optical fiber.14. The light source according to claim 12 , wherein the metal carbon nanotube and the electrodes are disposed on the substrate so that ...

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Номер записи: 61
11-04-2013 дата публикации

METHOD OF PRODUCING A HYDROGEL

Номер: US20130089592A1
Автор: Chimphango Annie Fabian Abel, Gorgens Johann Ferdinand, Van Zyl Willem Heber
Принадлежит: STELLENBOSCH UNIVERSITY

The invention provides a method of enzymatically modifying xylan by selectively removing glucuronic acid and/or arabinose side chains from the xylan with a-D-glucuronidase and/or a-L-arabinofuranosidase, and allowing the modified xylan to form into a hydrogel when the xylan becomes insoluble. A bioactive substance, such as a protein, enzyme, antimicrobial agent, bactericide or pharmaceutical compound can be added to the xylan so that the substance is encapsulated within the hydrogel or incorporated onto its surface. The hydrogel can be used as a drug delivery agent, such as for sustained-release or targeted drug delivery, rectal drug delivery or a dressing for a wound, burn or scar. The hydrogel can also be used as a coating, such as on medical gloves, catheters, surgical drainage systems, utensils or the like, or can be used in a scaffold for tissue engineering. 1. A method of producing a hydrogel , the method comprising the steps of:enzymatically modifying xylan which contains glucuronic acid or a derivative thereof and/or arabinose side chains so that it has reduced solubility in water compared to naturally occurring xylan, by selectively removing glucuronic acid and/or arabinose side chains from the xylan with one or both of α-D-glucuronidase and α-L-arabinofuranosidase; andallowing the modified xylan to form a hydrogel which encapsulates a bioactive substance, wherein the bioactive substance is brought into contact with the modified xylan either before the hydrogel forms or after the hydrogel forms.2. A method according to claim 1 , which further includes the steps of contacting the modified xylan with a bioactive substance and allowing the bioactive substance to be immobilized on or within the hydrogel.3. A method according to claim 2 , wherein the bioactive substance is added to the xylan before the hydrogel forms.4. A method according to claim 2 , wherein the bioactive substance is added to the xylan after formation of the hydrogel.5. A method according to ...

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Номер записи: 62
11-04-2013 дата публикации

SUSTAINED-RELEASE NANOPARTICLE COMPOSITIONS AND METHODS FOR USING THE SAME

Номер: US20130089616A1
Автор: Labhasetwar Vinod D., Reddy Maram K., Sahoo Sanjeeb K.
Принадлежит: Board of Regents of the University of Nebraska by and Behalf of the University of Nebraska Medical C

The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method for using the same in the treatment or prevention of a disease or condition. 13-. (canceled)4. A sustained-release nanoparticle composition comprising a therapeutic agent and a cross-linked copolymer of an N-alkylacrylamide , a vinyl monomer selected from the group consisting of a vinyl alcohol , a vinyl ether , a vinyl ester , vinyl pyrrolidone , or a combination of said vinyl monomers , and a polyethylene glycol (PEG) conjugate in nanoparticle form , wherein the weight per weight ratio of the N-alkylacrylamide , vinyl monomer and (PEG) conjugate is 70-90:9-20:1-10 , said therapeutic agent being encapsulated in said copolymer.5. The sustained-release nanoparticle composition of claim 4 , wherein said therapeutic agent is selected from the group consisting of antibiotics claim 4 , antirestenotics claim 4 , anti-proliferative agents claim 4 , anti-neoplastic agents claim 4 , chemotherapeutic agents claim 4 , cardiovascular agents claim 4 , anti-inflammatory agents claim 4 , immunosuppressive agents claim 4 , anti-apoptotic and anti-tissue damage agents.6. The sustained-release nanoparticle composition of claim 4 , wherein said therapeutic agent comprises an anti-proliferative agent.7. The sustained-release nanoparticle composition of claim 4 , wherein said ratio is 80:15:5.8. The sustained-release nanoparticle composition of claim 4 , wherein said nanoparticles have an average diameter in the range of 20 nm to 100 nm as measured by transmission electron microscopy.9. The sustained-release nanoparticle composition of claim 4 , wherein said therapeutic agent is an anti-apoptotic agent.10. The sustained-release nanoparticle composition of claim 9 , wherein said anti-apoptotic agent is selected from the group consisting of galectin-3 claim 9 , (-)deprenyl claim 9 , rapamycin ...

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Номер записи: 63
11-04-2013 дата публикации

COATED FIBRES, YARNS AND TEXTILES

Номер: US20130090030A1
Автор: Chaboche Laure, Decant Xavier, Esteve Nunez Helena, Eufinger Karin, Godefroidt Frank, Luyckx Dirk, Roshan Paul, Van De Vyver David, Van Parys Marc, Vanneste Myriam
Принадлежит: DEVAN CHEMICALS NV

A method of treatment for synthetic or natural fibre or yarn includes coating the fibre/yarn with a dispersion of carbon nanotubes in a coating composition which is cured by actinic radiation, such as UV, to provide a flexible conductive layer on the fibre/yarn. The liquid coating composition is sheared along the direction of a long axis of the yarn as it is applied to the yarn whereby the carbon nanotubes are substantially aligned prior to curing of the coating layer to provide improved longitudinal conductance. The method provides conductive fibre/yarn, from which anti-static textiles and fabrics can be formed, by treatment of conventional fibre/yarn and in a method with low energy consumption. The improved conductance allows thin or partial (e.g. stripe) coating layers to be used for yarns which provide good feel and handle, combined with good conductivity, for textiles formed from the yarns Coating compositions for use in the method are disclosed as are anti-static yarns, fibres fabrics and textiles resulting from the method. 115-. (canceled)16. A method for forming an electro-conductive yarn , the method comprising:a) applying a liquid coating composition, comprising a resin curable by actinic radiation, to the yarn to form a liquid coating layer on the yarn, andb) curing the liquid coating layer on the yarn with actinic radiation to form a solid coating layer on the yarn,wherein the liquid coating composition comprises carbon nanotubes dispersed therein,characterised in that the liquid coating composition is sheared along a direction parallel to a long axis of the yarn as it is applied to the yarn.17. The method of wherein the resin is selected from the group consisting of oligomers and/or monomers of acrylate and methacrylate adducts and mixtures thereof.18. The method of wherein the resin is selected from the group consisting of monomers and/or oligomers of adducts of acrylate and/or methacrylate with ester claim 17 , urethane claim 17 , epoxy claim 17 , ...

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Номер записи: 64
11-04-2013 дата публикации

SYNTHESIS OF ULTRASMALL METAL OXIDE NANOPARTICLES

Номер: US20130090511A1
Автор: Soultanidis Nikolaos, Wong Michael S.
Принадлежит: William Marsh Rice University

The invention generally relates to the ultrasmall MOnanoparticles that are made in a solvothermal method using water soluble inorganic ammonium salt precursors of the MOand organic amines, and slow heating to generate uniform ultrasmall MOnanoparticles of 5 nm or less, as well as methods to make and use same. 1. A method of making ultrasmall metal oxide nanoparticles , comprising;a) placing water soluble, inorganic ammonium oxometalate precursor in a reactor;b) adding an excess of amine surfactant to said reactor,c) optionally adding diols or amine oxides to said reactor;d) heating the reactor until the ammonium oxometalate precursor structure collapses and the nucleation stage generates ultrasmall metal oxide nanoparticles of average size≦5 nm.2. The method of claim 1 , wherein the ultrasmall metal oxide nanoparticles have about 20-50 metal atoms per nanoparticle.3. The method of wherein the ammonium oxometalate precursor is selected from the group consisting of ammonium metatungstate claim 1 , ammonium paratungstate claim 1 , phosphotungstic acid hydrate claim 1 , ammonium metamolybdate tetrahydrate claim 1 , ammonium metavanadate claim 1 , ammonium pentaborate octahydrate claim 1 , ammonium hexachloroosmate(IV) claim 1 , ammonium chromate claim 1 , ammonium perrhenate claim 1 , ammonium dihydrogenphosphate claim 1 , ammonium phosphomolybdate hydrate claim 1 , ammonium hexachloroiridate(IV) claim 1 , ammonium tetrathiomolybdate claim 1 , ammonium hexachloropalladate(IV) claim 1 , ammonium hexachlororhodate(III) claim 1 , and ammonium dichromate.4. The method of claim 1 , wherein the metal oxide is WO claim 1 , MoO claim 1 , VOor a doped variation of WO claim 1 , MoO claim 1 , and VO.5. The method of claim 1 , wherein the amine surfactant is oleylamine.6. A method of making ultrasmall metal oxide nanoparticles claim 1 , comprising;a) placing 1 part of water soluble, inorganic ammonium oxometalate precursor, which is fully oxidized and has structural stability up to ...

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Номер записи: 65
11-04-2013 дата публикации

Ultrasonic probe and ultrasonic diagnostic device

Номер: US20130090561A1
Автор: Koichi KUSUKAME, Takashi Ogura, Takayuki Nagata
Принадлежит: Panasonic Corp

An ultrasonic probe which has high propagation efficiency of ultrasound and can obtain a high resolution ultrasonic diagnostic image, the ultrasonic probe includes an ultrasonic transducer including: a piezoelectric body which generates ultrasound; and a first matching layer which is disposed in a predetermined direction as seen from the piezoelectric body and is for performing acoustic matching between the piezoelectric body and a subject, wherein the first matching layer includes a plurality of matching regions which have a uniform thickness in the predetermined direction, are arranged in a direction perpendicular to the predetermined direction, and include at least two matching regions having frequency characteristics of ultrasound transmittance different from each other.

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Номер записи: 66
18-04-2013 дата публикации

Processing for preparation of Boron Nanoparticles

Номер: US20130091763A1
Автор: PARTYKA Stanislas, Rottner Bernard
Принадлежит: ONECTRA

The invention relates to a method for providing boron nanoparticles, characterised in that it comprises at least the following steps: synthesising a boron/lithium LiB intermetallic compound by reacting a mixture of boron and lithium in a reactor, preferably under a vacuum and temperature of 650° C.; transferring and hydrolysing the boron/lithium intermetallic compound in order to produce boron nanoparticles, by immersion in a bath containing water at ambient temperature, under a neutral gas atmosphere such as argon; and separating the boron nanoparticles, especially by tangential filtration, from the other compounds produced by the hydrolysis reaction. The invention also relates to the use of boron nanoparticles. 1. A process for preparation of boron nanoparticles , comprising at least the following steps:a-1) synthesis of an intermetallic boron/lithium compound LiB by reaction of a mixture of boron and lithium in a reactor, preferably under vacuum and under heating of the order of 650° C.; anda-2) transfer and hydrolysis of the intermetallic boron/lithium compound for making boron nanoparticles by immersion in a bath containing water at ambient temperature under atmosphere of neutral gas such as argon; anda-3) separation of the boron nanoparticles, especially by filtration and/or centrifugation with the other compounds originating from the hydrolysis reaction.2. The process as claimed in claim 1 , wherein:in step a-1) the proportion of boron in the boron/lithium mixture introduced into said reactor is between 39% and 50%.3. The process as claimed in claim 1 , wherein:in step a-2) neutral gas, preferably argon, is bubbled in the hydrolysis bath.4. The process as claimed in claim 1 , wherein in step a-1) claim 1 , the hydrolysis bath is subjected to ultrasound.5. The process as claimed in claim 1 , wherein in step a-2) said bath contains water and a preferably anionic dispersant in a concentration appropriate for limiting growth of the nanoparticles.6. The process as ...

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Номер записи: 67
18-04-2013 дата публикации

METHOD FOR PRODUCING SINTERED RARE-EARTH MAGNET, SINTERED RARE-EARTH MAGNET, AND MATERIAL FOR SAME

Номер: US20130092867A1
Автор: KISHIMOTO Hidefumi, SAKUMA Noritsugu, SHOJI Tetsuya
Принадлежит: TOYOTA JIDOSHA KABUSHIKI KAISHA

A method for producing a sintered rare-earth magnet characterized by sintering a raw material that includes a ribbon-shaped polycrystalline phase with an average grain size of 10 to 200 nm fabricated by rapid solidification of an alloy melt having a rare-earth magnet composition, and a low-melting point phase formed on the surface of the polycrystalline phase and having a melting point lower than the polycrystalline phase. 1. A method for producing a sintered rare-earth magnet by comprising:preparing a ribbon composed of a polycrystalline phase including crystal grains with an average grain size of 10 to 200 nm by rapidly solidificating of an alloy melt having a rare-earth magnet composition;forming a low-melting point phase having a melting point lower than the polycrystalline phase on the surface of the ribbon; andsintering a raw material composed of the ribbon and the low-melting point phase.2. The method according to claim 1 , wherein the rapidly solidificating the alloy melt is performed by a single-roll process in which a single roll is used claim 1 , and the surface of the ribbon on which the low-melting point phase is formed is opposite to a surface in contact with the single roll.3. The method according to claim 1 , wherein the low-melting point phase is formed on one or both surfaces of the ribbon by an electrodeposition.4. The method according to claim 3 , wherein the electrodeposition is performed using an organic solvent or ionic liquid as an electrolyte liquid.5. The method according to claim 1 , wherein the average grain size of the crystal grains contained in the polycrystalline phase is 10 to 50 nm.6. The method according to claim 1 , wherein the sintering of the raw material includes pulverizing the raw material to obtain a powder claim 1 , and sintering the powder.7. A sintered rare-earth magnet being produced using the method according to .8. A raw material for a sintered rare-earth magnet comprising:a ribbon composed of a polycrystalline phase ...

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Номер записи: 68
18-04-2013 дата публикации

NUCLEIC ACID-MEDIATED SHAPE CONTROL OF NANOPARTICLES

Номер: US20130095039A1
Автор: Lu Yi, WANG Zidong
Принадлежит: The Board of Trustees of the University of Illinois

Embodiments of a method to use nucleic acid oligomer sequences for modulating the shape of nanoparticles are disclosed, as well as nanoparticles and methods of using the nanoparticles. Systematic variations of the nucleic acid sequences offer mechanistic insights into the morphology control. A plurality of nucleic acid oligomers is adsorbed onto a metal nanoseed to provide an oligomer-functionalized nanoparticle. Additional metal is deposited onto the oligomer-functionalized nanoparticle to produce a shaped nanoparticle having a morphology based at least in part on the nanoseed morphology and the oligomer's sequence composition. Embodiments of methods for using the shaped nanoparticles also are disclosed. 1. A method for making a shaped nanoparticle , comprising:providing a metal nanoseed;selecting a nucleic acid oligomer having an oligomer sequence composition comprising at least two unique sequence segments, each sequence segment having a length of at least five nucleobases selected from the group consisting of A, C, G, T, U, and modified nucleobases;adsorbing a plurality of the nucleic acid oligomers onto the metal nanoseed to produce an oligomer-functionalized nanoseed; anddepositing metal onto the oligomer-functionalized nanoseed to make a shaped nanoparticle, wherein the shaped nanoparticle has a morphology based at least in part on the oligomer sequence composition.2. The method of claim 1 , further comprising determining the morphology of the shaped nanoparticle claim 1 , wherein the morphology comprises shape claim 1 , surface characteristics claim 1 , or a combination thereof.3. The method of claim 2 , further comprising:providing a subsequent metal nanoseed having a morphology substantially similar to the metal nanoseed;selecting a subsequent nucleic acid oligomer having a subsequent oligomer sequence composition comprising at least two subsequent sequence segments, each subsequent sequence segment comprising nucleobases selected from the group consisting ...

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Номер записи: 69
18-04-2013 дата публикации

SOL-GEL NANOSTRUCTURED TITANIA RESERVOIRS FOR USE IN THE CONTROLLED RELEASE OF DRUGS IN THE CENTRAL NERVOUS SYSTEM AND METHOD OF SYNTHESIS

Номер: US20130095164A1
Автор: LÓPEZ-GOERNE Tessy María
Принадлежит: UNIVERSIDAD AUTONOMA METROPOLITAN

The invention is related to a method of administering a controlled release central nervous system drug by means of sol-gel nanostructured titania reservoir comprising silica, titania and silica-titania, and comprising partially hydrodyzed nano-materials. This reservoir may be in the form of a xerogel. 1. In a method of administering a controlled release central nervous system (CNS) drug to a patient in need thereof , the improvement wherein the drug is carried by a sol-gel nanostructured titania reservoir comprising silica , titania and silica-titania , and comprising partially hydrolyzed nano-materials.2. The method of claim 1 , wherein the reservoir is the form of a xerogel.3. The method of claim 2 , wherein the reservoir comprises a neurological drug occluded within its interior.4. The method of wherein the reservoir is biocompatible with a surrounding brain tissue. This invention is related to the synthesis of a titania reservoir which is biocompatible with brain tissue. The pore size distribution, crystallite size and the extant of the crystalline phase distribution of anatase, brookite and rutile can be fully controlled. This device will be used to contain neurological drugs. It will be inserted directly into brain tissue for the purpose of the controlled time release of drugs over a period of from 6 months to three years.State of the art research in the treatment of chronic diseases is based on the development of controlled release systems capable of delivering drugs rapidly and efficiently to where they are needed. A major requirement is that these devices should insure delivery and penetration of the drug to the active site. New naoostructured materials represent an efficient way to administer medications and biological products in future applications. Hydrogels based on N-isopropylacrilimide and metacrilic acids (MAA) have recently received considerable attention. This is due to their ability to swell in response to the stimulation of the medium. In the ...

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Номер записи: 70
18-04-2013 дата публикации

Metal-Containing Materials for Treatment of Bacterial Conditions

Номер: US20130095184A1
Автор: Lyczak Jeffrey B., Schechter Paul, Thompson Katherine, Turner Katherine
Принадлежит: NUCRYST PHARMACEUTICALS CORP.

Metal-containing materials, as well as their preparation, formulations, and use are disclosed. 1. A method , comprising:contacting an area of a subject with a nanocrystalline silver-containing material, and killing bacterial spores in the area with the nanocrystalline silver-containing material.2Clostridium difficileClostridium perfringensClostridium tetaniClostridium botulinumBacillus cereusBacillus anthracis. The method of claim 1 , wherein the bacterial spores are selected from the group consisting of spores claim 1 , spores claim 1 , spores claim 1 , spores claim 1 , spores claim 1 , spores claim 1 , and combinations thereof.3. The method of claim 1 , wherein the area of the subject further comprises a sporulating bacterial infection.4Clostridium. The method of claim 3 , wherein the sporulating bacterial infection comprises a infection.5ClostridiumClostridium difficileClostridium perfringensClostridium tetaniClostridium botulinum. The method of claim 4 , wherein the infection is selected from the group consisting of infection claim 4 , infection claim 4 , infection claim 4 , and infection.6Clostridium difficile. The method of claim 3 , wherein the sporulating bacterial infection comprises a infection.7Bacillus. The method of claim 3 , wherein the sporulating bacterial infection comprises a infection.8BacillusBacillus cereusBacillus anthracis. The method of claim 7 , wherein the sporulating infection is selected from the group consisting of infection and infection.913-. (canceled)14. The method of claim 1 , further comprising contacting the area with a non-metal antibiotic medication.15. The method of claim 14 , wherein the non-metal antibiotic medication is selected from the group consisting of vancomycin claim 14 , metronidazole claim 14 , benzoxazinorifamycin claim 14 , rifaximin claim 14 , and combinations thereof.16. The method of claim 15 , wherein the non-metal antibiotic medication is vancomycin.17. The method of claim 15 , wherein the non-metal ...

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Номер записи: 71
18-04-2013 дата публикации

IMMOBILIZED CARBON NANOTUBES ON VARIOUS SURFACES

Номер: US20130095314A1
Автор: Marti-Arbona Angel A., Pasquali Matteo, Saha Avishek
Принадлежит: William Marsh Rice University

In some embodiments, the present invention provides methods of immobilizing carbon nanotubes on a surface, wherein the method comprises: (1) mixing carbon nanotubes with a superacid to form a carbon nanotube solution; and (2) exposing the carbon nanotube solution to the surface. The exposing results in the immobilization of the carbon nanotubes on the surface. In some embodiments, the method occurs without the utilization of carbon nanotube wrapping molecules. Other embodiments of the present invention pertain to systems that comprise immobilized carbon nanotubes on a surface, as developed by the aforementioned methods. 1. A method of immobilizing carbon nanotubes on a surface , wherein the method comprises:a. mixing carbon nanotubes with a superacid to form a carbon nanotube solution; andb. exposing the carbon nanotube solution to the surface, wherein the exposing results in the immobilization of the carbon nanotubes on the surface, and wherein the method occurs without the utilization of carbon nanotube wrapping molecules.2. The method of claim 1 , wherein the carbon nanotubes comprise pristine carbon nanotubes.3. The method of claim 1 , wherein the carbon nanotubes are selected from the group consisting of single-walled carbon nanotubes claim 1 , double-walled carbon nanotubes claim 1 , multi-walled carbon nanotubes claim 1 , small diameter carbon nanotubes claim 1 , ultra-short carbon nanotubes claim 1 , and combinations thereof.4. The method of claim 1 , wherein the superacid is selected from the group consisting of oleum claim 1 , chlorosulfonic acid claim 1 , trifluoromethanesulfonic acid claim 1 , triflic acid claim 1 , fluorosulfonic acid claim 1 , perchloric acid claim 1 , anhydrous hydrogen fluoride claim 1 , Bronsted acid/Lewis acid complexes claim 1 , and combinations thereof.5. The method of claim 1 , wherein the superacid is chlorosulfonic acid.6. The method of claim 1 , wherein the carbon nanotube solution comprises protonated carbon nanotubes.7. The ...

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Номер записи: 72
18-04-2013 дата публикации

COMPOSITE OF METAL OXIDE NANOPARTICLES AND CARBON, METHOD OF PRODUCTION THEREOF, ELECTRODE AND ELECTROCHEMICAL ELEMENT EMPLOYING SAID COMPOSITE

Номер: US20130095384A1
Автор: Ishimoto Shuichi, Naoi Katsuhiko, Naoi Wako, Tamamitsu Kenji
Принадлежит:

A composite powder in which highly dispersed metal oxide nanoparticle precursors are supported on carbon is rapidly heated under nitrogen atmosphere, crystallization of metal oxide is allowed to progress, and highly dispersed metal oxide nanoparticles are supported by carbon. The metal oxide nanoparticle precursors and carbon nanoparticles supporting said precursors are prepared by a mechanochemical reaction that applies sheer stress and centrifugal force to a reactant in a rotating reactor. The rapid heating treatment in said nitrogen atmosphere is desirably heating to 400° C.-1000° C. By further crushing the heated composite, its aggregation is eliminated and the dispersity of metal oxide nanoparticles is made more uniform. Examples of a metal oxide that can be used are manganese oxide, lithium iron phosphate, and lithium titanate. Carbons that can be used are carbon nanofiber and Ketjen Black. 1. A method for producing a composite of metal oxide nanoparticles and carbon in which sheer stress and centrifugal force is applied to a solution including a starting material of metal oxide and carbon powder in a rotating reactor to allow reaction and obtain a composite powder in which highly dispersed metal oxide nanoparticle precursors are supported on carbon under nitrogen atmosphere , and the composite powder is rapidly heated under nitrogen atmosphere to allow progression of crystallization of metal oxide so that metal oxide nanoparticles having ultra thin film structure is highly dispersed and supported by the carbon.2. The method for producing a composite of metal oxide nanoparticles and carbon according to claim 1 , wherein the composite powder is rapidly heated under nitrogen atmosphere to 400-1000° C.3. The method for producing a composite of metal oxide nanoparticles and carbon according to claim 2 , wherein sheer stress and centrifugal force is applied to the solution including a reaction suppressor along with a reactant in said reactor to allow reaction.4. ...

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Номер записи: 73
18-04-2013 дата публикации

Reagents and methods for phosphorylation/dephosphorylation analyses

Номер: US20130095502A1
Автор: Anton B. Iliuk, Weiguo A. Tao
Принадлежит: PURDUE RESEARCH FOUNDATION

Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that produces a signal or that binds to a molecule that produces a signal. The reagent may also include a moiety that binds to a larger molecule or to a surface. Some forms of the reagent include a dendrimer that can simultaneously bind to multiple metal moieties that include a metal such as titanium and multiple moieties that can be used to detected bound molecules. These reagents can be used in detection and/or measurement and/or at least partial purification of phosphorylated molecules. These reagents and methods using them are used to analyze proteins, polypeptides, nucleic acids, phospholipids and the like. They are readily adapted for use in gels, blots, plate based high through put assays and for mass spectrometry.

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Номер записи: 74
18-04-2013 дата публикации

siRNA conjugate and preparation method thereof

Номер: US20130096288A1
Автор: Han Bo Ram, Lee Sam Young, Park Han Oh, Shin Mi Sik
Принадлежит: BIONEER CORPORATION

Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system. 1. A conjugate of survivin-specific siRNA and polymer compound , of the structure below:{'br': None, 'A-X—R—Y—B'}(where, one of A and B is a hydrophilic polymer compound and the other thereof is a hydrophobic polymer compound; X and Y each are independently a simple covalent bond or a linker-mediated covalent bond; and R is a survivin-specific siRNA.)2. The conjugate of claim 1 , wherein a single strand of the survivin-specific siRNA (R) is composed of 19 to 31 nucleotides.3. The conjugate of claim 1 , wherein the survivin-specific siRNA (R) is any one selected from nucleotide sequences of SEQ ID NOs.: 1 to 4.4. The conjugate of claim 1 , wherein the survivin-specific siRNA(R) has chemical modification.5. The conjugate of claim 4 , wherein the chemical modification includes at least one selected from:modifying a phosphorodiester bond into a phosphorothioate linkage;{'sub': '3', 'modifying —OH at the 2′-position of a pentose into 2′-OCHor 2′-dioxy-2′-fluouridine; and'}modifying —OH at the 2′ position of the pentose into an LNA type formed by linking the 2′ position and the 4′ position of the pentose.6. The conjugate of claim 1 , wherein the hydrophobic polymer compound has a molecular weight of 250 to 1 claim 1 ,000; the hydrophilic polymer compound is a non-ionic polymer ...

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Номер записи: 75
25-04-2013 дата публикации

Electrical Conductor With Surrounding Electrical Insulation

Номер: US20130099621A1
Автор: Björklund Anders, Hillborg Henrik, Sahlen Fredrik
Принадлежит:

An electrical conductor provided with an electrical insulation system surrounding the conductor, the insulation includes a first insulation layer surrounding the conductor and a second insulation layer surrounding the first insulation layer. The second insulation layer includes a second polymer and a second filler in the form of chromium oxide (CrO), iron oxide (FeO), or a mixture of chromium oxide and iron oxide, wherein the first insulation layer includes a first polymer and a first filler including dispersed nanoparticles. 1. An electrical conductor provided with an electrical insulation system surrounding the electrical conductor , the electrical insulation system comprises a first electrical insulation layer surrounding the conductor and a second electrical insulation layer surrounding the first electrical insulation layer , wherein the second electrical insulation layer comprises a second polymer and a second filler in the form of chromium oxide , iron oxide , or a mixture of chromium oxide and iron oxide , characterized in that the first electrical insulation layer comprises a first polymer and a first filler comprising dispersed nanoparticles.2. The electrical conductor according to claim 1 , wherein the second filler is present in an amount of 10-40% of the volume of the second electrical insulation layer.3. The electrical conductor according to claim 1 , wherein the second insulation filler has an average particle size of 0.005-30 μm.4. The electrical conductor according to claim 1 , wherein the second insulation filler has a resistivity of 10-10ohm m.5. The electrical conductor according to claim 1 , wherein the second polymer is at least one of the following polymers: polyesters claim 1 , polyesterimides claim 1 , polyamideimides claim 1 , polyesteramides claim 1 , polyimides claim 1 , polyurethanes claim 1 , epoxy and polyamides.6. The electrical conductor according to claim 1 , wherein the second insulation layer has a thickness of 5-50 μm.7. The ...

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Номер записи: 76
25-04-2013 дата публикации

IN VIVO IMAGING OF ENZYMATIC ACTIVITY

Номер: US20130101511A1
Автор: Ansaldi Daniel, Francis Kevin P., Singh Rajendra, Zhang Ning
Принадлежит:

Compositions and methods are described for detecting enzyme activity in a live organism (e.g., animal) are provided. 1. A composition comprising a chemiluminescent enzymatic probe and a near-infrared (NIR) nanop article.2. The composition of claim 1 , wherein the chemiluminescent enzymatic probe comprises luminol.3. The composition of claim 1 , wherein the NIR nanoparticle further comprises a targeting moiety.4. The composition of claim 3 , wherein the targeting moiety is selected from the group consisting of an antibody claim 3 , an antibody fragment claim 3 , a small molecule claim 3 , an apatmer and a polypeptide.5. A method of monitoring enzymatic activity in a live animal claim 3 , the method comprising:administering a chemiluminescent enzymatic probe to the animal;administering a near-infrared (NIR) nanoparticle to the animal, wherein the nanoparticle emits light upon exposure to the chemiluminescence emitted from the chemiluminescent enzymatic probe;detecting the light emitted from the light nanoparticle, thereby monitoring enzymatic activity in the live animal.6. The method of wherein the chemiluminescent enzymatic probe comprises luminol.7. The method of claim 6 , wherein ROS activity is monitored.8. The method of claim 6 , wherein a cancer is detected.9. The method of claim 6 , wherein the enzymatic activity is indicative of an inflammatory response.10. The method of claim 9 , wherein the inflammatory response is in the lungs.11. The method of claim 6 , wherein the enzymatic activity is indicative of the present of a tumor or tumor metastases.12. A method of detecting a cancer in a live animal claim 6 , the method comprising:administering a chemiluminescent enzymatic probe to the animal;administering a near-infrared (NIR) nanoparticle to the animal, wherein the nanoparticle emits light upon exposure to the chemiluminescence emitted from the chemiluminescent enzymatic probe;detecting the light emitted from the NIR nanoparticle, thereby monitoring the cancer ...

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Номер записи: 77
25-04-2013 дата публикации

LOGICAL ENZYME TRIGGERED (LET) LAYER-BY-LAYER NANOCAPSULES FOR DRUG DELIVERY SYSTEM

Номер: US20130101669A1
Автор: Appleford Mark, Kelley Marie-Michelle
Принадлежит:

Nanocapsule compositions comprising a calcium carbonate core surrounded by a bilayer or bilayers of polystyrene sulfonate and poly(allylamine hydrochloride). The poly(allylamine hydrochloride) is conjugate to a substrate, wherein the substrate is capable of being acted upon (for example cleaved) by a biomarker or enzyme associated with a disease state of interest. The nanocapsule compositions may be administered to an animal, for example a human, for the treatment of a disease state. 1. A nanocapsule composition comprising:a calm carbonate core:a bilayer comprising polystyrene sulfonate and poly(allylamine hydrochloride), wherein the bilayer substantially surrounds the calcium carbonate core; anda substrate capable of being activated b) contacting a biomarker for a disease state, wherein the substrate is immobilized onto the surface of the bilayer.2. The nanocapsule composition of claim 1 , further comprising additional polystyrene sulfonate and poly(allylamine hydrochloride) bilayers claim 1 , wherein the bilayers substantially surround the calcium carbonate core.3. The nanocapsule composition of claim 1 , wherein the substrate is an MMP-cleavable substrate.4. The nanocapsule composition of claim 3 , wherein the MMP-cleavable substrate is MMP-2-cleavable claim 3 , MMP-9-cleavable.5. The nanocapsule composition of claim 1 , wherein the substrate is a combination of both MMP-2 cleavable substrate and MMP-9-cleavable substrate.6. A method for treating a disease state claim 1 , comprising the step of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering the nanocapsule composition to an animal.'} This invention was made in part during work supported by a grant from the UTSA MBRS-RISE PROGRAM. Grant Number GM60655 with Edwin J Barea-Rodriguez as the Principal Investigator. The government may have certain rights in the invention.The present invention relates generally to drug delivery systems, and more specifically to the use of layered nanocapsules for the ...

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Номер записи: 78
25-04-2013 дата публикации

MULTI-LEG LUMINESCENT NANOPARTICLES, MULTI-LEG LUMINESCENT NANOPARTICLE COMPOUNDS AND VARIOUS APPLICATIONS

Номер: US20130101999A1
Автор: Amin Himanshu Subhash, Chakravarthy Krishnan, Kamisetti Siddhartha
Принадлежит: NANOAXIS, LLC

Multi-leg luminescent nanoparticles (“MLN's”) that can be paired to other MLN's as well s biological molecules to film branched multi-leg luminescent nanoparticles (“BMLN's) that can be used in biological multiplexing applications, imaging applications, biological detection applications and other biological applications. 1. A multi-leg luminescent nanoparticle , comprising:one or more legs extending from a base wherein the one or more legs and the base comprise a luminescent semiconductor nanoparticle;a shell that coats the one or more legs and the base; anda pairing moiety connected to the shell coated one or more legs and base, and configured to connect to an targeting molecule.2. The nanoparticle of claim 1 , wherein the base and one or more legs are a semiconductor or a III-V semiconductor.3. The nanoparticle of claim 2 , wherein the base and one or more legs are a II-VI semiconductor.4. The nanoparticle of claim 2 , wherein the base and one or more legs are a semiconductor.5. The nanoparticle of claim 3 , wherein the semiconductor is MgS claim 3 , MgSe claim 3 , MgTe claim 3 , CaS claim 3 , CaSe claim 3 , CaTe claim 3 , SrS claim 3 , SrSe claim 3 , SrTe claim 3 , BaS claim 3 , BaSe claim 3 , BaTe claim 3 , ZnS claim 3 , ZnSe claim 3 , ZnTe claim 3 , CdS claim 3 , CdSe claim 3 , CdTe claim 3 , HgS claim 3 , HgSe claim 3 , or HgTe.6. The nanoparticle of claim 4 , wherein the semiconductor is GaAs claim 4 , InGaAs claim 4 , InP claim 4 , or InAs.7. The nanoparticle of claim 1 , wherein the shell semiconductor is a II-VI semiconductor or a III-V semiconductor.8. The nanoparticle of claim 7 , wherein said shell is a II-VI semiconductor or a III-V semiconductor.9. The nanoparticle of claim 8 , wherein the semiconductor is MgS claim 8 , MgSe claim 8 , MgTe claim 8 , CaS claim 8 , CaSe claim 8 , CaTe claim 8 , SrS claim 8 , SrSe claim 8 , SrTe claim 8 , BaS claim 8 , BaSe claim 8 , BaTe claim 8 , ZnS claim 8 , ZnSe claim 8 , ZnTe claim 8 , CdS claim 8 , CdSe claim 8 , ...

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Номер записи: 79
25-04-2013 дата публикации

SYSTEMS AND METHODS FOR HIGH-THROUGHPUT DETECTION OF AN ANALYTE IN A SAMPLE

Номер: US20130102489A1
Автор: Osterfeld Sebastian J., Wang Shan X.
Принадлежит: MagArray, Inc.

Provided are high-throughput detection systems. The systems include a magnetic sensor device, a magnetic field source and a reservoir plate that includes a plurality of fluid reservoirs. The magnetic sensor device includes a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end. Also provided are methods in which the subject high-throughput detection systems find use. 119-. (canceled)20. A reservoir plate comprising:an addressable array of fluid reservoirs comprising two or more rows of fluid reservoirs and two or more columns of fluid reservoirs, wherein the fluid reservoirs in each row have the same volume and at least two fluid reservoirs in separate columns have different volumes.21. The reservoir plate of claim 20 , wherein the array of fluid reservoirs comprises 24 or more fluid reservoirs.22. The reservoir plate of claim 20 , wherein each fluid reservoir has a volume of 1 mL or less.23. The reservoir plate of claim 20 , wherein the reservoir plate is configured to operatively couple to a reservoir plate actuator configured to move the reservoir plate along an axis of movement.24. The reservoir plate of claim 23 , further comprising an alignment guide configured to align a longitudinal axis of the reservoir plate parallel to the axis of movement.25. A method for determining whether an analyte is present in a sample claim 23 , the method comprising:(a) contacting a magnetic sensor device with a set of samples contained in a set of fluid reservoirs to generate a signal, the magnetic sensor device comprising a support with two or more elongated regions each having a magnetic sensor array disposed at a distal end; and(b) determining whether the analyte is present in each sample based on the signal.26. The method of claim 25 , wherein each magnetic sensor array comprises one or more magnetic sensors having an analyte-specific probe bound to a surface of the magnetic sensor.27. The method of claim 25 , wherein the ...

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Номер записи: 80
25-04-2013 дата публикации

COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF PULMONARY HYPERTENSION

Номер: US20130102591A1
Автор: Magdassi Shlomo, Margulis-Goshen Katrin, Salzman Andrew Lurie
Принадлежит:

The invention provides compositions and methods for prevention, treatment, or management of pulmonary hypertension using piperidine, pyrrolidine, or azepane derivatives comprising one to four nitric oxide (NO) donor groups and a reactive oxygen species (ROS) degradation catalyst. The invention further provides a water dispersible powder comprising nanoparticles comprising said derivatives, as well as pharmaceutical compositions thereof and methods of use. 2. The method of claim 1 , wherein Reach independently is selected from the group consisting of H claim 1 , —COOR claim 1 , —CON(R) claim 1 , and an NO-donor group; and Ris H.3. The method of claim 1 , wherein Reach independently is (C-C)alkyl claim 1 , preferably (C-C)alkyl claim 1 , more preferably (C-C)alkyl claim 1 , most preferably methyl.4. The method of claim 3 , wherein Rare identical.5. The method of claim 1 , wherein in said NO-donor group claim 1 , Xis absent or —O—; Xis absent or (C-C)alkylene claim 1 , preferably (C-C)alkylene claim 1 , more preferably (C-C)alkylene claim 1 , most preferably methylene; Xis —NO or —ONO claim 1 , preferably —ONO; and said alkylene is optionally substituted by one or more —ONOgroups and optionally further substituted by a moiety of the general formula D.6. The method of claim 1 , wherein (i) n is 1; and one or two of the carbon atoms at positions 3 or 4 of the pyrrolidine ring are linked to an NO-donor group; (ii) n is 2; and one or more of the carbon atoms at positions 3 to 5 of the piperidine ring are linked to an NO-donor group; or (iii) n is 3; and one or more of the carbon atoms at positions 3 to 6 of the azepane ring are linked to an NO-donor group.7. The method of claim 6 , wherein said compound comprises more than one identical or different NO-donor groups.8. The method of claim 6 , wherein each one of said NO-donor groups independently is of the formula —(C-C)alkylene-ONO claim 6 , preferably —(C-C)alkylene-ONO claim 6 , more preferably —CH—ONO claim 6 , or —O—(C ...

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Номер записи: 81
25-04-2013 дата публикации

Liposome comprising elastin-like polypeptide and tumor cell targeting material and use thereof

Номер: US20130102993A1
Автор: Hyun Ryoung KIM, Jae Chan Park, Min Sang Kim, Sang Joon Park, Su Young Chae
Принадлежит: SAMSUNG ELECTRONICS CO LTD

A liposome including an elastin-like polypeptide (ELP) and a tumor cell targeting material, a pharmaceutical composition including the liposome, and a method of delivering an active agent to a target site using the liposome.

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Номер записи: 82
02-05-2013 дата публикации

CONTRAST AGENTS

Номер: US20130108554A1
Автор: Aslam Mohammed, Dravid Vinayak P., Meade Thomas J., Schultz Sikma Elise A., Ulrich Bradley D.
Принадлежит: Northwestern University

The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T) and transverse (T) relaxation times of surrounding water proton spins. 1. A magnetic resonance contrast agent composition comprising one or more Tcontrast agent portions , and one or more Tcontrast agent portions , wherein said one or more Tcontrast agent portions comprise a paramagnetic metal ion chelate , and wherein said one or more Tcontrast agent portions comprise paramagnetic nanoparticle.2. The magnetic resonance contrast agent composition of claim 1 , further comprising one or more linker regions.3. The magnetic resonance contrast agent composition of claim 1 , wherein said paramagnetic metal ion is Gd(III).4. The magnetic resonance contrast agent composition of claim 2 , wherein said linker region is a cleavable linker region.5. The magnetic resonance contrast agent composition of claim 4 , wherein said cleavable linker region comprises a peptide linker portion.6. The magnetic resonance contrast agent composition of claim 5 , wherein said peptide linker portion comprises a MMP-7 peptide linker.7. The magnetic resonance contrast agent composition of claim 2 , wherein said linker region connects one said Tcontrast agent portion to one said Tcontrast agent.8. The magnetic resonance contrast agent composition of claim 2 , wherein a Tcontrast agent portion is connected to more than one T-relaxation contrast agent portions by multiple linkers.9. The magnetic resonance contrast agent composition of claim 1 , wherein more than one Tcontrast agent portions are connected to more than one Tcontrast agent portions by multiple linkers.10. The magnetic resonance contrast agent composition of claim 1 , further comprising an imaging tag.11. The magnetic resonance contrast agent composition of claim 10 , wherein said imaging tag is and optical imaging tag. ...

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Номер записи: 83
02-05-2013 дата публикации

NANOPARTICULATE IN-SITU GELS AS VITREOUS HUMOR SUBSTITUTES FOR OCULAR DISEASES

Номер: US20130108648A1
Автор: Banerjee Rinti, Carvalho Edmund
Принадлежит: INDIAN INSTITUTE OF TECHNOLOGY BOMBAY

The present technology provides a nanoparticulate in-situ gelling vitreous substitute, which is a liquid at room temperature to aid easy administration, such as e.g. through a small needle incision, and forms a gel within the eye, which is hydrophilic in nature, similar to the natural vitreous. The vitreous substitute formulation may include a water-soluble natural or synthetic polymer and a gelling-agent which are blended together in the presence of a cross linker, to form a gel having the properties of the vitreous humor. The process of cross linking and gelation may occur in-situ. This can be achieved by dispensing to the eye, different components of the vitreous substitute in liquid state, along with the cross linking agent. 123.-. (canceled)24. A method for delivery of a drug to the vitreous cavity of an eye of a subject comprising: administering to the vitreous cavity a liquid vitreous substitute comprising α-tocopheryl polyethylene glycol succinate (TPGS) , a polymeric blend of gellan and polyvinyl alcohol (PVA) and the drug.25. The method of claim 24 , wherein the polymeric blend comprises PVA and gellan in a ratio of from about 2:1 (w/w) to about 8:1 (w/w).26. The method of claim 24 , wherein the polymeric blend is present at a final concentration from about 3% to about 7% by weight.27. The method of claim 24 , wherein the TPGS is present at a final concentration from about 1 to about 2 mg/mL.28. The method of claim 24 , wherein the vitreous substitute comprises nanoparticles loaded with the drug.29. The method of claim 28 , wherein the nanoparticles comprise biocompatible claim 28 , biodegradable hydrophilic polymers.30. The method of claim 28 , wherein the nanoparticles comprise one or more compounds selected from the group consisting of: chitosan claim 28 , polyethylene oxide claim 28 , alginate claim 28 , polyacrylate claim 28 , methyl methacrylate and salts thereof claim 28 , polycaprolactone claim 28 , albumin claim 28 , gelatin and solid lipid ...

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Номер записи: 84
02-05-2013 дата публикации

AQUEOUS PROCESSING OF COMPOSITE LITHIUM ION ELECTRODE MATERIAL

Номер: US20130108776A1
Автор: Armstrong Beth L., Daniel Claus, III David L., Li Jianlin, Wood
Принадлежит: UT-BATTELLE, LLC

A method of making a battery electrode includes the steps of dispersing an active electrode material and a conductive additive in water with at least one dispersant to create a mixed dispersion; treating a surface of a current collector to raise the surface energy of the surface to at least the surface tension of the mixed dispersion; depositing the dispersed active electrode material and conductive additive on a current collector; and heating the coated surface to remove water from the coating. 1. A method of making a battery electrode , comprising the steps of:dispersing an active electrode material and a conductive additive in water with at least one dispersant to create a mixed dispersion;treating a surface of a current collector to raise the surface energy of the surface to at least the surface tension of the mixed dispersion;depositing the dispersed active electrode material and conductive additive on a current collector; and,heating the coated surface to remove solvent from the coating.2. The method of claim 1 , wherein the active electrode material is a cathode material.3. The method of claim 2 , wherein the cathode material is at least one selected from the group consisting of LiCoO claim 2 , LiNiO claim 2 , LiMnO claim 2 , LiFePO claim 2 , LiMnPO claim 2 , LiFeMnPO claim 2 , LiNiMnCoO claim 2 , LiNiMnCoO claim 2 , LiNiMnCoAlO claim 2 , LiNiMnCoO claim 2 , and CuZnSn(S claim 2 ,Se).4. The method of claim 1 , wherein the active electrode material is an anode material.5. The method of claim 4 , wherein the anode material is at least one selected from the group consisting of synthetic graphite particulate claim 4 , natural graphite particulate claim 4 , Si particle—C fiber nanocomposites claim 4 , LiTiO claim 4 , LiTiO claim 4 , Sn particulate claim 4 , and Si particulate.6. The method of claim 1 , wherein the conductive additive is at least one selected from the group consisting of carbon black claim 1 , graphite particulate claim 1 , graphene claim 1 , and ...

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Номер записи: 85
02-05-2013 дата публикации

NANO-COATINGS FOR ARTICLES

Номер: US20130108800A1
Автор: Agrawal Gaurav, Chakraborty Soma, ZHU Jiang
Принадлежит: BAKER HUGHES INCORPORATED

A composite includes a substrate, a binder layer disposed on a surface of the substrate; and a nanofiller layer comprising nanographene and disposed on a surface of the binder layer opposite the substrate. In addition, a nano-coating layer for coating a substrate includes multiple alternating layers of the binder layer and the nanofiller layer. Articles coated with the nano-coating layer prepared from alternating layers of nanofiller layer and binder layer have improved barrier properties, and may be used in down-hole applications. 1. A method of forming a nano-coating on an article , comprising:depositing multiple alternating layers of:a first layer on a surface of a substrate, the first layer comprising a polymeric composition; anda second layer comprising nanographene on a surface of the first layer opposite the substrate, the nanographene being derivatized with a functional group comprising carboxy, epoxy, ether, ketone, amine, hydroxyl, alkoxy, alkyl, lactones, aryl, functionalized polymeric or oligomeric groups, or a combination comprising at least one of the forgoing functional groups,wherein successive occurrences of a first layer are deposited on successive occurrences of a second layer.2. The method of claim 1 , further comprising treating the substrate by a corona treatment claim 1 , organosilane treatment claim 1 , or polymer-based primer treatment.3. The method of claim 1 , wherein the depositing comprises film casting claim 1 , spin coating claim 1 , dip coating claim 1 , spray coating claim 1 , layer-by-layer coating claim 1 , or a combination comprising at least one of the forgoing.4. The method of claim 1 , wherein the nanographene is exfoliated by fluorination claim 1 , acid intercalation claim 1 , acid intercalation followed by thermal shock treatment claim 1 , or a combination comprising at least one of the foregoing.5. The method of claim 1 , wherein the substrate comprises fluoroelastomers claim 1 , perfluoroelastomers claim 1 , hydrogenated ...

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Номер записи: 86
02-05-2013 дата публикации

STRUCTURED CATALYTIC NANOPARTICLES AND METHOD OF PREPARATION

Номер: US20130109600A1
Автор: Allston Thomas D., Difrancisco Albert Gary, Hailstone Richard K., Prok Gary R., Reed Kenneth J.
Принадлежит: Cerion Technology, Inc.

A method of making a structured, doped, cerium oxide nanoparticle includes (a) forming a first reaction mixture including cerium(III), an optional metal ion other than cerium, a base, a stabilizer, and a solvent, (b) contacting the first reaction mixture with an oxidant, (c) forming a cerium oxide nanoparticle core by heating the product of step (b), (d) forming a second reaction mixture by combining with the first reaction mixture one or more metal ions other than cerium, and an optional additional quantity of cerium(III), and (e) forming a shell surrounding the core of cerium oxide by heating the second reaction mixture to produce a product dispersion of structured cerium oxide nanoparticles. 1. A method of making a structured , doped , cerium oxide nanoparticle , comprising:a. forming a first reaction mixture comprising cerium(III), an optional metal ion other than cerium, a base, a stabilizer, and a solvent;b. contacting said first reaction mixture with an oxidant;c. forming a cerium oxide nanoparticle core by heating the product of step b);d. forming a second reaction mixture by combining with the first reaction mixture one or more metal ions other than cerium, and an optional additional quantity of cerium(III); ande. forming a shell surrounding said core of cerium oxide by heating said second reaction mixture to produce a product dispersion of structured cerium oxide nanoparticles.2. The method of claim 1 , wherein the first reaction mixture further comprises one or more metal ions other than cerium; and wherein the identity and/or relative quantity of metal ions differs from that of the second reaction mixture.3. The method of claim 1 , wherein step d) further comprises addition of cerium (III) ions and oxidant.4. The method of claim 1 , wherein the heating of step c) or step e) raises the reaction mixture to about 50° C. to 100° C.5. The method of claim 1 , wherein the addition of metal ions in step d) is performed concurrently with the addition of the ...

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Номер записи: 87
09-05-2013 дата публикации

PHOTOVOLTAIC CELL

Номер: US20130112254A1
Автор: Lorenzetti Cesare, VITALE MARCELLO
Принадлежит: BASF SE

A photovoltaic cell of high efficiency may be obtained using metallic nanoparticles or nanostructures as the main light absorbing element in the photosensitive layer of the cell, which absorb the light through a surface plasmon or polaron mechanism. The cell comprises at least one photosensitive layer containing nanoparticles or nanostructures each between a n-doped and a p-doped charge transport layer, characterized in that 1. A photovoltaic cell comprising at least one photosensitive layer containing nanoparticles or nanostructures and additionally comprising at least one n-doped charge transport layer and at least one p-doped charge transport layer per each photosensitive layer placed on each side of said photosensitive layer , characterized in that the nanoparticles or nanostructures are the main light absorbing element in the photosensitive layer ,the nanoparticles or nanostructures show metallic conductivity and absorb near infrared, visible and/or ultraviolet light through a surface plasmon or polaron mechanism,the nanoparticles or nanostructures have at least one of their dimensions of size between 0.1 and 500 nm,at least 50% by weight of said nanoparticles or nanostructures from all layers are contained in said photosensitive layer and{'sub': 2', '2', '2, 'where the p-doped charge transport layers comprise a material selected from p-type amorphous silicon, amorphous silicon carbide, microcrystalline silicon, microcrystalline silicon carbide, carbon-containing microcrystalline silicon, a multilayer film of amorphous silicon carbides having different carbon contents and a multilayer film of amorphous silicon and amorphous carbon; and/or the n-doped charge transport layers comprise a material selected from n-type microcrystalline silicon, crystalline silicon, carbon-containing microcrystalline silicon, microcrystalline silicon carbide, amorphous silicon, amorphous silicon carbide and amorphous silicon germanium; or one or both charge transport layers consist ...

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Номер записи: 88
09-05-2013 дата публикации

NANOWIRE-BASED OPTOELECTRONIC DEVICE FOR LIGHT EMISSION

Номер: US20130112945A1
Автор: BAVENCOVE Anne-Laure, GILET Philippe
Принадлежит: Commissariat A L'Energie Atomique Et Aux Energies Alternatives

An optoelectronic device includes: 1. An optoelectronic device comprising:an active semiconductor area for the radiative recombination of electron-hole pairs made in the form of at least one nanowire made of an unintentionally doped semiconductor material;a semiconductor area for the radial injection of holes into the or each nanowire, made of a doped semiconductor material having a first conductivity type and a bandgap smaller than the bandgap of the material forming the nanowire; anda semiconductor area for the axial injection of electrons into the or each nanowire, made of a doped semiconductor material having a second conductivity type opposite to the first conductivity type.2. The optoelectronic device of claim 1 , wherein the active area for the radiative recombination of electron-hole pairs is made of a single semiconductor material.3. The optoelectronic device of claim 2 , wherein the active area for the radiative recombination of electron-hole pairs is formed of a semiconductor material of III-V type or of II-VI type claim 2 , and in particular of III-N type.4. The optoelectronic device of claim 3 , wherein:the active area for the radiative recombination of electron-hole pairs is formed of unintentionally doped InGaN;the doped area for the injection of holes is formed of p-doped GaN or of p-doped InGaN with a lower In concentration than the active area; andthe doped area for the injection of electrons is formed of n-doped Si or of n-doped GaN.7. The optoelectronic device of claim 3 , wherein the active area for the radiative recombination of electron-hole pairs is made of InGaN claim 3 , and:{'sup': 8', '10, 'the nanowires have a density ranging between 10and 10per square centimeter;'}the nanowires have a diameter ranging between 50 nanometers and 500 nanometers; andthe height of the active area for the radiative recombination of electron-hole pairs of the nanowires ranges between 40 nanometers and 5 micrometers.8. The optoelectronic device of claim 4 , ...

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Номер записи: 89
09-05-2013 дата публикации

FULL SPECTRUM SOLID STATE WHITE LIGHT SOURCE, METHOD FOR MANUFACTURING AND APPLICATIONS

Номер: US20130113011A1
Автор: Dutta Partha S.
Принадлежит:

A method of manufacturing a down-conversion substrate for use in a light system includes forming a first crystallography layer including one or more phosphor materials and, optionally, applying at least one activator to the crystallography layer, heating the crystallography layer at high temperature to promote crystal growth in the crystallography layer, and drawing out the crystallography layer and allowing the crystallography layer to cool to form the down-conversion substrate. A light system includes an excitation source for emitting short wavelength primary emissions; and a down-conversion substrate disposed in the path of at least some of the primary emissions from the excitation source to convert at least a portion of the primary emissions into longer-wavelength secondary emissions, wherein the substrate includes one or more crystallography layers, wherein each crystallography layer includes one or more phosphor materials, and optionally at least one activator. Down-converted secondary light may be produced by the system. 1. A method of manufacturing a down-conversion substrate for use in a light system , the method comprising:forming a first crystallography layer comprising one or more phosphor materials and, optionally, applying at least one activator to the crystallography layer;heating the crystallography layer at high temperature to promote crystal growth in the crystallography layer; anddrawing out the crystallography layer and allowing the crystallography layer to cool to form the down-conversion substrate.2. The method of claim 1 , further comprising depositing one or more additional crystallography layers comprising one or more phosphor materials upon the first crystallography layer and claim 1 , optionally claim 1 , applying at least one activator to each of the one or more additional crystallography layers.3. The method of claim 1 , wherein the first crystallography layer is formed by gradually adding the phosphor materials into a molten compound ...

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Номер записи: 90
09-05-2013 дата публикации

APTAMER-LOADED, BIOCOMPATIBLE NANOCONSTRUCTS FOR NUCLEAR-TARGETED CANCER THERAPY

Номер: US20130115254A1
Автор: Dam Duncan-Hieu M., Lee Jung Heon, Odom Teri W.
Принадлежит: Northwestern University

Disclosed herein is a nanoconstruct comprising an aptamer and a gold nanostar. The nanoconstruct can be used in a method of inducing changes to a nuclear phenotype of a cell comprising transporting the nanoconstruct to a nucleus of a cell, and releasing the aptamer from a surface of the gold nanostar into the nucleus of the cell to afford deformations or invaginations in the nuclear membrane, thereby inducing changes to the nuclear phenotype. The method can be used to treat certain hyperproliferative disorders such as cancer. 1. A method of inducing changes to a nuclear phenotype of a cell comprisingtransporting a nanoconstruct comprising an aptamer and a gold nanostar to a nucleus of a cell, andreleasing the aptamer from the surface of the gold nanostar into the nucleus of the cell to afford invaginations in nuclear membrane, thereby inducing changes to the nuclear phenotype.2. A method according to wherein the aptamer is AS-1411.3. A method according to wherein the cell is a cancer cell.4. A method according to wherein the nanoconstruct is transported to the nucleus of the cell by binding to nucleolin to form a complex claim 1 , the complex internalized by the cell.5. A method according to wherein the aptamer is released from the surface of the gold nanostar by exposing the nanoconstruct to infrared light.6. A method according to wherein the invaginations lead to an increase in caspase activity.7. A method according to wherein the caspase is selected from the group of caspase 3 claim 6 , caspase 7 and both caspase 3 and caspase 7.8. A method according to wherein the increase in caspase activity induces cell apoptosis.9. A method according to wherein the invaginations in nuclear membrane lead to decreased cell viability.10. A method according to wherein the cell is a cancer cell.11. A method according to wherein the cell is a cancer cell.12. A two-component nanoconstruct comprising an aptamer and a gold nanostar.13. A two-component nanoconstruct according to ...

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Номер записи: 91
16-05-2013 дата публикации

FILTER MEDIA FOR A LIQUID FILTER USING AN ELECTROSPUN NANOFIBER WEB, METHOD FOR MANUFACTURING SAME, AND LIQUID FILTER USING SAME

Номер: US20130118973A1
Автор: JUNG Yong Sik, LEE SEUNG HOON, SEO In Yong
Принадлежит: AMOGREENTECH CO., LTD.

Provided is a filter medium for a liquid filter, having a three-dimensional micropore structure of a multi-layered structure using a multilayer nanofiber web that is obtained by performing air-electrospinning, to thus be thin but have high efficiency and long life, a method of manufacturing the filter medium using the multilayer nanofiber web, and a liquid filter using the filter medium. The filter medium for a liquid filter, includes: a nanofiber web that is made by stacking nanofibers that are obtained by air-electrospinning a fibrous polymer material and that have micropores; and a supporter that is inserted and combined onto one surface or in an inner portion of the nanofiber web. 1. A filter medium for a liquid filter , comprising:a nanofiber web made by stacking nanofibers that are obtained by air-electrospinning a fibrous polymer material and that have micropores; anda supporter that is combined onto one surface of the nanofiber web or is inserted in an inner portion of the nanofiber web.2. The filter medium for a liquid filter according to claim 1 , wherein the nanofiber web is formed by stacking a number of nanofiber webs in a multi-layered structure claim 1 , in which the nanofiber web of each layer has a different structure claim 1 , depending on a degree of volatilization of a solvent by heat compression claim 1 , to thus perform surface filtration or depth filtration.3. The filter medium for a liquid filter according to claim 1 , wherein the supporter is a nonwoven fabric or imitation vellum paper.4. The filter medium for a liquid filter according to claim 1 , wherein the polymer material of about 5 to about 22.5 wt % is mixed in a spinning solution for air-electrospinning.5. The filter medium for a liquid filter according to claim 1 , wherein a solvent that is used in the spinning solution is a 2-component solvent that is obtained by mixing a solvent with a relatively high boiling point (BP) and a solvent with a relatively low boiling point (BP).6. The ...

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Номер записи: 92
16-05-2013 дата публикации

HEAT TRANSFER ENHANCING AGENT

Номер: US20130119302A1
Автор: Chen Hung-Wei, HUANG YEN-HAO
Принадлежит:

An enhancing agent for increasing heat transfer efficiency is disclosed, which is an additive composed of a nano-scale powder and a micro-scale powder that is to be added into a heat-transfer fluid circulating in an heat exchange system or in a coolant circulating in a cooling system for enhancing the heat conductivity of the heat-transfer fluid or the coolant while helping the tank and the fluid passages used in those systems to maintain clean, and eventually enabling those systems to operate with improved heat dissipation effect. By adding the aforesaid enhancing agent into a cooling system of an internal-combustion engine, the heat shock inside the engine that is originated from the fuel burning in the engine can be reduced, resulting that not only the amount of green house gas emission is reduced, but also the chance of engine juddering that is generally originated from poor heat dissipation can be decreased. 1. An agent for enhancing heat transfer efficiency , comprising: a nano-scale powder and a micro-scale power.2. The agent of claim 1 , wherein each particle of the nano-scale powder is formed with a particle size smaller than 100 nanometers claim 1 , and each particle of the micro-scale powder is formed with a particle size ranged between 100 nanometers and 500 micrometers.3. The agent of claim 1 , wherein the total weigh of the nano-scale powder and the micro-scale power is larger than 15% of the gross weight of the enhancing agent.4. The agent of claim 1 , wherein the weigh of the scale powder is larger than 10% of the gross weight of the enhancing agent.5. The agent of claim 1 , wherein each of the nano-scale powder and the micro-scale powder is made of a material selected from the group consisting of: a metal claim 1 , an alloy claim 1 , a non-metallic material claim 1 , a metallic compound claim 1 , and a non-metallic compound.6. The agent of claim 5 , wherein the metal is a material selected from the group consisting of: titanium claim 5 , vanadium ...

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Номер записи: 93
16-05-2013 дата публикации

GRAPHENE TRANSISTOR HAVING AIR GAP, HYBRID TRANSISTOR HAVING THE SAME, AND METHODS OF FABRICATING THE SAME

Номер: US20130119349A1
Автор: Chung Hyun-jong, Chung U-in, KIM Ki-nam
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

A graphene transistor includes: a gate electrode on a substrate; a gate insulating layer on the gate electrode; a graphene channel on the gate insulating layer; a source electrode and a drain electrode on the graphene channel, the source and drain electrode being separate from each other; and a cover that covers upper surfaces of the source electrode and the drain electrode and forms an air gap above the graphene channel between the source electrode and the drain electrode. 1. A graphene transistor comprising:a gate electrode on a substrate;a gate insulating layer on the gate electrode;a graphene channel on the gate insulating layer;a source electrode and a drain electrode on the graphene channel, the source electrode and drain electrode being separate from each other; anda cover that covers upper surfaces of the source electrode and the drain electrode and forms an air gap above the graphene channel between the source electrode and the drain electrode.2. The graphene transistor of claim 1 , wherein a length of the graphene channel between the source electrode and the drain electrode is in a range of about 10 nm to about 100 nm.3. The graphene transistor of claim 1 , wherein the cover is formed of a porous polymer or a porous insulating material.4. The graphene transistor of claim 1 , wherein the air gap has a height in a range of about 20 nm to about 200 nm.5. The graphene transistor of claim 1 , wherein the gate insulating layer is formed of hexagonal boron nitride.6. The graphene transistor of claim 5 , wherein the gate insulating layer has a thickness in a range of about 0.5 nm to about 30 nm.7. The graphene transistor of claim 1 , wherein the graphene channel is formed of one to five graphene layers.8. The graphene transistor of claim 1 , wherein the source electrode and the drain electrode are on opposite sides of the graphene channel and include a plurality of interdigitated source and drain finger electrodes claim 1 , and the gate electrode includes a ...

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Номер записи: 94
16-05-2013 дата публикации

Lipid-Peptide-Polymer Conjugates and Nanoparticles Thereof

Номер: US20130121917A1
Автор: Dong He, Shu Jessica, Xu Ting
Принадлежит: Lawrence Berkeley National Laboratory

The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided. 1. A conjugate comprising:a peptide having from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure;a first polymer covalently linked to the peptide; anda hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety.2. The conjugate of claim 1 , wherein the peptide is selected from the group consisting of SEQ ID NO: 1 (1CW) claim 1 , SEQ ID NO: 2 (BB) claim 1 , SEQ ID NO: 4 (SR) claim 1 , and SEQ ID NO: 5 (1coi-W).3. The conjugate of claim 1 , wherein the first polymer is a hydrophilic polymer.4. The conjugate of claim 1 , wherein the first polymer is polyethyleneglycol.5. The conjugate of claim 1 , wherein the second polymer comprises polybutadiene.6. The conjugate of claim 1 , wherein the lipid moiety comprises from 1 to 6 Calkyl groups.7. The conjugate of claim 1 , wherein the lipid moiety comprises 1 claim 1 , 2 or 4 Calkyl groups.8. The conjugate of claim 1 , further comprising an amino acid residue covalently linked to the C-terminus of the peptide.9. The conjugate of claim 8 , wherein the amino acid residue comprises a member selected from the group consisting of GGG claim 8 , HHH claim 8 , KK claim 8 , EE claim 8 , RGD and AYSSGAPPMPPF.10. The conjugate of claim 1 , whereinthe peptide comprises SEQ ID NO:1 (1CW);the first polymer comprises ...

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Номер записи: 95
16-05-2013 дата публикации

Nanotubes as Mitochondrial Uncouplers

Номер: US20130122063A1
Автор: Sullivan Patrick
Принадлежит: University of Kentucky Research Foundation

A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Cainto mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided. 1. A method of reducing the effects of traumatic brain injury in an individual comprising:administering a therapeutically effective amount of nanotubes into the individual, wherein the nanotubes are self-rectifying nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present.2. The method of claim 1 , wherein the individual is a mammal.3. The method of claim 1 , wherein the nanotubes have an inner diameter designed for uncoupling mitochondria.4. The method of claim 1 , wherein the nanotubes have an inner diameter designed for self-rectifying the nanotubes.5. The method of claim 4 , wherein the nanotubes are made from metals or polymers.6. The method of claim 5 , wherein the metals include gold and silver.7. The method of claim 5 , wherein the polymers include natural or synthetic polymers.8. The method of claim 5 , wherein the polymers can be selected from the group consisting of poly(vinyl alcohol) claim 5 , poly(esters) claim 5 , polyglycolide claim 5 , polycaprolactone claim 5 , poly(ethylene oxide) claim 5 , poly(butylene terephthalate) claim 5 , poly(hydroxyalkanoates) claim 5 , hydrogels claim 5 , modified poly(saccharides) claim 5 , starch claim 5 , cellulose claim 5 , and chitosan.9. A method of reducing the effects ...

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Номер записи: 96
16-05-2013 дата публикации

Prodrug compositions, prodrug nanoparticles, and methods of use thereof

Номер: US20130122100A1
Автор: Dipanjan Pan, Gregory M. Lanza
Принадлежит: Washington University in St Louis WUSTL

Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents.

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Номер записи: 97
16-05-2013 дата публикации

KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID

Номер: US20130122577A1
Автор: KIM Su-hyeon, LEE Jeong-gun, RHEE Joo-won, SONG Mi-jeong
Принадлежит: SAMSUNG ELECTRONICS CO., LTD.

Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined. 1. A kit for determining a nucleotide sequence of a target nucleic acid comprising: at least one sequence specific binding protein and a detectable tag.2. The kit of claim 1 , wherein the target nucleic acid has a length of 1 kb to 10 Mb.3. The kit of claim 1 , wherein the target nucleic acid is double stranded.4. The kit of claim 1 , wherein the sequence specific binding protein comprises at least one motif selected from the group consisting of a zinc finger motif claim 1 , a helix-turn-helix motif claim 1 , a helix-loop-helix motif claim 1 , a leucine zipper motif claim 1 , a nucleic acid-binding motif of restriction endonuclease claim 1 , and a combination thereof.5. The kit of claim 1 , wherein the detectable tag comprises at least one selected from the group consisting of a colored bead claim 1 , a chromophore claim 1 , a fluorescent material claim 1 , a fluorescent protein claim 1 , a phosphorescent material claim 1 , an electrically detectable molecule claim 1 , a molecule providing modified fluorescence-polarization or modified light-diffusion claim 1 , a quantum dotand a combination thereof.6. The kit of claim 5 , wherein the fluorescent protein is selected from the group consisting of a yellow fluorescent protein (YFP) claim 5 , a green fluorescent protein (GFP) claim 5 , a red fluorescent protein (RFP) and a combination thereof.7. The kit of claim 1 , wherein the detectable tag is linked to the sequence specific binding protein by a linker.8. A gene construct comprising a polynucleotide ...

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Номер записи: 98
16-05-2013 дата публикации

Methods. particles, and assay kits for identifying presence of biological parameters

Номер: US20130123145A1
Автор: Krishnan Chakravarthy, Siddhartha Kamisetti
Принадлежит: NanoAxis LLC

Multiplexed assays are disclosed for detection of duster differentiation 4 (CD4) glycoprotein expressed on the cell surface of I-helper cells, monocytes, macrophages, and dendritic cells; cluster differentiation 25 (CD25), a type transmembrane protein present on activated T-cells, activated B-cells, thymocytes, myeloid precursors, and oligodendrocytes; and Forkhead box P3 (FOXP3), an intracellular protein involved in immune system responses in cell cultures, tissues samples, humans, and biological samples. The multiplexed assays can be used to detect 1r-cells, activated I-cells, and other similar cell types (e.g. natural T regulatory cells, adaptive/induced T regulatory T cells). The multiplexed assays employ quantum dots of various shapes, types, compositions, coatings, sizes, ligands and other such characteristics.

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Номер записи: 99
23-05-2013 дата публикации

CARBON NANOFIBER CONTAINING METAL OXIDE OR INTERMETALLIC COMPOUND, PREPARATION METHOD THEREOF, AND LITHIUM SECONDARY BATTERY USING SAME

Номер: US20130126794A1
Автор: Jung Hong Ryun, Lee Wan Jin
Принадлежит: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

The present invention relates to a method for preparing a carbon nanofiber in which a nano-sized metal oxide or an intermetallic compound is dispersed, and more specifically, provides a preparation method comprising the step of electrospinning a metal precursor/carbon fiber precursor solution and heat treating the same. The carbon nanofiber containing a metal oxide or an intermetallic compound can be used as an anode material for a secondary battery. According to the present invention, a secondary battery using the carbon nanofiber containing a metal oxide or an intermetallic compound as an anode material has excellent capacity, and shows excellent cycle stability, in other words, maintains a capacity of 90% or more of the initial capacity even after 100 cycles, and the like. 115-. (canceled)16. A method of manufacturing a metal oxide-containing carbon nanofiber , comprising:adding a tin precursor or a copper precursor to a carbon fiber precursor material to manufacture a fiber precursor composite;spinning the fiber precursor composite to manufacture a fiber; andheat treating the fiber.17. The method according to claim 16 , further comprising:carbonizing the heat treated fiber; andactivating the carbonized fiber.18. The method according to claim 16 , wherein the fiber precursor composite further includes a polyvinylpyrrolidone resin.19. The method according to claim 16 , wherein the fiber precursor composite further includes a compound having an oxygen atom as a donor atom.20. The method according to claim 19 , wherein the compound having oxygen atom as the donor atom includes any one or more functional groups selected from RO— claim 19 , —C═O— claim 19 , —CO— claim 19 , —SO— claim 19 , —O—R—CO— claim 19 , —O—R—O— claim 19 , —OCR—CO— claim 19 , —NH—R—CO— claim 19 , and —NH—R—O— (where R is an alkyl group of C1 to C20 claim 19 , or an aryl group or a substituted aryl group of C6 to C20).21. The method according to claim 16 , wherein the carbon fiber precursor ...

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Номер записи: 100