08-08-2013 дата публикации
Номер: US20130202567A1
The present disclosure provides cell culture medium comprising trimethylamine N-oxide (TMAO). Progenitor cells cultured with such medium can form connective tissue with enhanced mechanical properties. Also provided are methods of forming connective tissue and methods of treatment for connective tissue defects. 115-. (canceled)16. A chondrogenic tissue culture medium comprising trimethylamine N-oxide (TMAO).17. The medium of claim 16 , comprising about 10 mM claim 16 , about 20 mM claim 16 , about 30 mM claim 16 , about 40 mM claim 16 , about 50 mM claim 16 , about 60 mM claim 16 , about 70 mM claim 16 , about 80 mM claim 16 , about 90 mM claim 16 , about 100 mM claim 16 , about 110 mM claim 16 , about 120 mM claim 16 , about 130 mM claim 16 , about 140 mM claim 16 , about 150 mM claim 16 , about 160 mM claim 16 , about 170 mM claim 16 , about 180 mM claim 16 , about 190 mM claim 16 , about 200 mM claim 16 , about 250 mM claim 16 , about 300 mM claim 16 , about 400 mM claim 16 , about 450 mM claim 16 , about 500 mM claim 16 , about 550 mM claim 16 , about 600 mM claim 16 , about 650 mM claim 16 , about 700 mM claim 16 , about 750 mM claim 16 , about 800 mM claim 16 , about 850 mM claim 16 , about 900 mM claim 16 , about 950 mM claim 16 , or about 1 claim 16 ,000 mM TMAO.18. The medium of claim 16 , further comprising urea.19. The medium of claim 18 , comprising about 10 mM claim 18 , about 20 mM claim 18 , about 30 mM claim 18 , about 40 mM claim 18 , about 50 mM claim 18 , about 60 mM claim 18 , about 70 mM claim 18 , about 80 mM claim 18 , about 90 mM claim 18 , about 100 mM claim 18 , about 110 mM claim 18 , about 120 mM claim 18 , about 130 mM claim 18 , about 140 mM claim 18 , about 150 mM claim 18 , about 160 mM claim 18 , about 170 mM claim 18 , about 180 mM claim 18 , about 190 mM claim 18 , about 200 mM claim 18 , about 250 mM claim 18 , about 300 mM claim 18 , about 400 mM claim 18 , about 450 mM claim 18 , about 500 mM claim 18 , about 550 mM claim 18 , ...
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