24-10-2019 дата публикации
Номер: WO2019200500A1
Принадлежит:
Disclosed in the present invention is a method for preparing 1,2,4-triazole, comprising using a fluoroborate aryl diazonium salt, a diazoester derivative and an organic nitrile as reaction substrates, using a transition metal as a catalyst, and using an inorganic base as an additive to prepare 1,2,4-triazole by means of cyclization. The method used in the present invention has the following characteristics: The reaction is more economical, the substrate is more universal, the post-functionalization is easier, the reaction conditions are mild, the reaction can be performed in air, the catalyst amount used is less, and the post-treatment is simple, being beneficial to the purification and industrial application of the product. Meanwhile, in the present invention, the raw materials such as the reactants and the catalyst used are inexpensive and easily available, the reaction composition is reasonable, no ligand is needed, there are less reaction steps, and only one step of reaction is required ...
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