23-05-2023 дата публикации
Номер: CN116143756A
Принадлежит:
The invention belongs to the technical field of topiroxostat, and discloses a preparation method of topiroxostat, which comprises the following steps: condensing a compound IV with hydrazine hydrate to generate a compound III, reacting with a compound V to generate a compound II, cyclizing the compound II to obtain a topiroxostat I crude product, salifying the topiroxostat I crude product with organic sulfonic acid, and dissolving the salt by potassium carbonate to obtain the topiroxostat. A certain amount of metal ion complexing agent is added in the salt dissolving process to remove residual heavy metal ions, and then the I-crystal-form topiroxostat is obtained through water pulping and water-miscible solvent pulping. According to the preparation method, a plurality of mutagenic warning structure impurities generated in the production process can be effectively controlled, the generation of cyano hydrolysis impurities can be remarkably reduced, the product quality is improved, the production ...
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