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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 6. Отображено 6.
06-07-2017 дата публикации

MUTANT VIRUS, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Номер: WO2017113786A1
Автор: ZHOU, Demin, SI, Longlong, ZHOU, Xueying, ZHANG, Ziwei, XU, Huan, TIAN, Zhenyu, ZHANG, Chuanling, XIAO, Sulong, XIA, Qing, ZHANG, Lihe
Принадлежит:

The present invention provides a mutant virus, preferably an influenza virus, from a human or another animal, and a preparation method for the mutant virus. The method comprises of introducing a UAG codon upstream of an endogenous stop codon of one or more genes in a viral genome. The invention further provides applications of the mutant virus as an attenuated live vaccine or as a replicable and controllable safe virus model.

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Номер записи: 1
01-05-2014 дата публикации

TRITERPENE DERIVATIVE AND ITS ANTI-INFLUENZA USE

Номер: WO2014063441A1
Автор: ZHOU, Demin, YU, Maorong, XIAO, Sulong, YU, Fei, PENG, Yiyun, QIU, Yunyan, ZHANG, Lihe
Принадлежит:

The present invention relates to a use of a triterpene derivative of formula (I) for producing drugs which can be used for the prevention or treatment of influenza diseases, wherein the substituents are as defined in the specification. The triterpene derivative in the present invention has a significant inhabitation effect to influenza virus, can significantly inhibit the influenza virus from entering a cell, and can be used for the prevention or treatment of influenza.

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Номер записи: 2
07-05-2015 дата публикации

ADENO-ASSOCIATED VIRUS WITH SITE-DIRECTED MUTAGENESIS AND SITE-DIRECTED MODIFICATION, AND PREPARATION METHOD AND APPLICATION THEREFOR

Номер: WO2015062516A1
Автор: ZHOU, Demin, ZHANG, Chuanling, XIAO, Sulong, YAO, Tianzhuo, ZHENG, Yongxiang, YU, Fei, SI, Longlong, ZHANG, Lihe
Принадлежит:

Provided is an adeno-associated virus with site-directed mutagenesis and site-directed modification, and a preparation method therefor. Genetic code expansion techniques are used to incorporate non-natural amino acids into an adeno-associated virus capsid protein VP1 or fragment thereof, thereby obtaining an adeno-associated virus with site-directed mutagenesis using non-natural amino acids. The present adeno-associated virus with site-directed mutagenesis is equivalent to a wild-type virus in terms of production, transduction and mobility, can couple with other functional molecules, such as a target molecule, and can carry a functional gene in a normal manner, acting as an adeno-associated virus vector.

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Номер записи: 3
11-06-2015 дата публикации

MODIFIED PEGYLATED RECOMBINANT HUMAN INTERFERON Α 2B AND METHOD FOR PREPARING SAME

Номер: WO2015081858A1
Автор: ZHOU, Demin, ZHANG, Bo, CHEN, Jingxian, YU, Fei, ZHANG, Chuanling, SI, Longlong, WU, Ling
Принадлежит:

Provided is a human interferon, wherein at least one amino acid residue is replaced with Lys-azido. Further provided is a pegylated human interferon, which improves in vivo stability of the human interferon. Additionally, provided is a method for preparing the interferon and a pegylated product thereof, which comprises using a plasmid which can express tRNAPyl/PylRS.

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Номер записи: 4
27-12-2012 дата публикации

SENSITIZER FOR REVERSING OR REDUCING RADIOTHERAPY RESISTANCE IN CASES OF ESOPHAGEAL CARCINOMA, SCREENING METHOD AND USE THEREOF

Номер: WO2012175052A1
Автор: ZHOU, Demin, GAO, Xianshu, XIONG, Wei, ZHAO, Jing, ZHANG, Lihe
Принадлежит:

Provided is a sensitizer for reversing or reducing radiotherapy resistance in cases of esophageal carcinoma, a screening method and uses thereof, said sensitizer being a gene expression inhibitor or silencing-agent of AKR1C3. By silencing the gene AKR1C3, the present invention is able effectively to achieve a sensitization effect for radiotherapy, thereby enabling individualized treatment to be better performed and a more effective therapeutic regime to be provided for the treatment of esophageal carcinoma.

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Номер записи: 5
02-05-2023 дата публикации

Receptor biased pegylated IL-2 variant combinations and uses thereof

Номер: CN116036243A
Автор: ZHOU DEMIN, JI DEZHONG, SUN JIAQI, ZHANG BO
Принадлежит:

The invention relates to the field of immunotherapy, in particular to site-specific modified PEGylated IL-2 variants, so as to provide a combination of PEGylated IL-2 variants with different receptor bias. The composition inhibits the amplification of immunosuppressive lymphocytes and reduces the terminal differentiation and depletion of effector lymphocytes through a synergistic effect, and has a synergistic anti-tumor effect, so that the composition can be used for enhancing immune response and treating proliferative diseases such as tumors. Besides, the composition can also be used for in-vitro culture of immune cells in adoptive cellular immunotherapy, aging and depletion of the immune cells are reduced, and fate of the immune cells in adoptive cellular immunotherapy is guided to long-term immunity. Thus, the invention also provides combination therapies for enhancing immune responses, treating proliferative diseases such as tumors, and in vitro methods of making or culturing immune ...

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Номер записи: 6