13-06-2023 дата публикации
Номер: CN116253643A
Принадлежит:
The invention relates to a safe production method of musk ketone, which comprises the following steps: dissolving 4-tert-butyl-2, 6-dimethyl acetyl benzene in trichloroethane to obtain a 4-tert-butyl-2, 6-dimethyl acetyl benzene solution; preparing fuming nitric acid and concentrated sulfuric acid for later use; cooling a cooling system of the tubular reactor; the method comprises the following steps: pumping a 4-tert-butyl-2, 6-dimethyl acetyl benzene solution, fuming nitric acid and a concentrated sulfuric acid solution into a tubular reactor through a peristaltic pump and an independent valve; recovering the solvent, and carrying out precipitation crystallization on the solvent; and carrying out vacuum drying on the crystallized product to obtain the final product musk ketone crystal. The tubular reactor is adopted, and compared with a conventional intermittent reactor, a flowing structure in the tubular reactor can greatly enhance quality and heat transfer, so that nitration reaction ...
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