02-06-2023 дата публикации
Номер: CN116199596A
Принадлежит:
The invention discloses a terbutaline metabolite preparation method, which comprises: (1) dissolving a raw material A in an organic solvent, adding an alkali, adding a raw material B, and carrying out a substitution reaction to obtain an intermediate product C; (2) dissolving the intermediate C in an organic solvent, then adding a reducing agent, and carrying out reduction reaction and carbonyl reduction to obtain an intermediate product D; (3) dissolving the intermediate product D in a solvent, performing deprotection reaction, and removing protecting groups X and R on hydroxyl to obtain a target product terbutaline metabolite E; according to the method, cheap raw materials are adopted, three-step reaction is carried out, the reaction condition is mild, the yield is high, the chemical purity of the obtained product E can reach 98.5% or above, and the method has great application research value in the metabolic process of terbutaline in organisms and in clinical pharmacokinetic research ...
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