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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 29. Отображено 29.
01-11-2018 дата публикации

PORCINE CIRCOVIRUS TYPE 3 IMMUNOGENIC COMPOSITION, PREPARATION METHOD, AND APPLICATION

Номер: WO2018196836A1
Автор: TIAN, Kegong, YUAN, Yuren, LI, Xiangdong, YIN, Bo, XIAO, Yan, LU, Zhou, HU, Dongxue, SUN, Jinzhong, MO, Xiaobing, ZHANG, Xuke
Принадлежит:

Provided are a porcine circovirus type 3 immunogenic protein and an immunogenic composition prepared from the immunogenic protein. Also provided are a method for preparing the immunogenic composition and an application of the immunogenic composition in preparing a drug for preventing and/or treating a porcine circovirus type 3 associated disease.

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Номер записи: 1
12-09-2017 дата публикации

A vaccine composition and its preparation method and application

Номер: CN0104288762B
Автор: 张许科, 孙进忠, 田克恭
Принадлежит:

... 本发明提供了种疫苗组合物，该疫苗组合物含有免疫量的猪瘟病毒抗原、免疫量的副猪嗜血杆菌抗原、免疫量的猪圆环病毒2型抗原以及兽医学上可接受的载体。该疫苗组合物能有效地同时防治猪瘟、猪圆环病毒病和副猪嗜血杆菌病，其次注射即可达到单苗注射2次的免疫效果，副反应小，免疫期长，耗时少、费力少。 ...

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Номер записи: 2
12-09-2017 дата публикации

A vaccine composition and its preparation method and application

Номер: CN0104258389B
Автор: 张许科, 孙进忠, 李雪锋, 李成山, 田克恭
Принадлежит:

... 本发明提供了种疫苗组合物，其中，该疫苗组合物包括免疫量的鸡新城疫病毒抗原、鸡传染性支气管炎病毒抗原以及鸡滑液囊支原体抗原以及载体。本发明还提供了该疫苗组合物地制备方法和应用。本发明三联苗免疫效果要优于新支二联灭活苗与鸡滑液囊支原体灭活单苗疫苗联用的免疫效果。本发明进步提供了种疫苗组合物，该疫苗组合物除上述三中抗原还包括鸡毒支原体抗原，该疫苗组合物能有效抵抗四种病原的攻击。 ...

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Номер записи: 3
13-12-2018 дата публикации

BIVALENT VACCINE COMPOSITION FOR PREVENTING AND/OR TREATING PORCINE CIRCOVIRUS INFECTIONS AND PREPARATION METHOD AND USE THEREOF

Номер: WO2018223668A1
Автор: TIAN, Kegong, LI, Xiangdong, XIAO, Yan, XI, Xiangfeng, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

Disclosed is a vaccine composition for preventing and/or treating porcine circovirus infections, comprising an immune amount of a porcine circovirus type 3 antigen, an immune amount of a porcine circovirus type 2 antigen and a pharmaceutically acceptable carrier. The vaccine composition can prevent and/or treat related diseases caused by infection or mixed infection with different gene subtypes of porcine circoviruses, and same can have an immune protective efficacy on strains from different geographical origins.

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Номер записи: 4
12-09-2017 дата публикации

A vaccine composition and its preparation method and application

Номер: CN0104208666B
Автор: 张许科, 孙进忠, 田克恭
Принадлежит:

... 本发明提供了种疫苗组合物，该疫苗组合物包括：免疫量的支气管败血波氏杆菌抗原、免疫量的多杀性巴氏杆菌的类毒素抗原及兽医学上可接受的佐剂。该疫苗组合物能有效的防治由支气管波氏杆菌、多杀性巴氏杆菌引起的混合感染的猪萎缩性鼻炎，及进步包括其他其他抗原成分，防治由猪萎缩性鼻炎继发感染的呼吸系统综合征。本发明通过减少抗原成分，用多杀性巴氏杆菌类毒素来替代多杀性巴氏杆菌不同血清型的抗原，达到了预防猪萎缩性鼻炎的目的；还通过提高疫苗组合物单位体积的抗原含量，使疫苗组合物免疫剂量降低到现有疫苗的1/4剂量，免疫效果没有降低。因此，本发明提供了种免疫剂量更低，抗原成分更少，免疫成本更低，使用方便的疫苗组合物。 ...

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Номер записи: 5
28-04-2023 дата публикации

African swine fever virus subunit vaccine composition, African swine fever virus protein antigen composition and application

Номер: CN116019905A
Автор: TIAN KEGONG, PANG WENQIANG, ZHANG XUKE
Принадлежит:

The invention provides an African swine fever virus subunit vaccine composition. The African swine fever virus subunit vaccine composition is prepared from the following components in immune dose: African swine fever virus p72 protein, p30 protein, p54 protein, African swine fever virus nucleocapsid assembly protein, African swine fever virus replication protein, African swine fever virus adsorption protein and African swine fever virus virulence protein, the African swine fever virus subunit vaccine composition further comprises a pharmaceutically acceptable carrier. The invention also provides a combination of African swine fever virus protein antigens. The combination of the African swine fever virus subunit vaccine composition and the African swine fever virus protein antigens can provide good immune efficacy for pigs, the protein antigens have a synergistic effect, and better immune efficacy can be provided under the condition of low total protein content.

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Номер записи: 6
25-07-2023 дата публикации

Preparation method of glasspitron and intermediate thereof

Номер: CN116478155A
Автор: ZHANG XUKE, HOU LIN
Принадлежит:

The invention relates to a preparation method of glapirant and an intermediate of the glapirant, and particularly relates to a preparation method of the glapirant and the intermediate of the glapirant. The preparation method of the glasspitron comprises the following steps: nitrating a compound in a formula I to obtain a compound in a formula II; reacting the compound of formula II with a compound of formula III to obtain a compound of formula IV; reducing nitryl in the compound of formula IV to obtain a compound of formula V; cyclizing an amino functional group and an aminopyridine functional group of the compound of formula V to obtain a compound of formula VI; brominating the compound of formula VI to obtain a compound of formula VII; reducing carbonyl in the compound shown in the formula VII to obtain a compound shown in a formula VIII; reacting the compound in the formula VIII with organic amine or organic amine salt, and hydrolyzing under an acidic condition to obtain a compound in ...

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Номер записи: 7
04-10-2018 дата публикации

PORCINE CIRCOVIRUS TYPE 3 STRAIN AND VACCINE COMPOSITION, PREPARATION METHOD, AND APPLICATION THEREOF

Номер: WO2018176887A1
Автор: TIAN, Kegong, LI, Xiangdong, XIAO, Yan, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

A porcine circovirus type 3 virus strain and a vaccine composition prepared by an immunogenic material of the strain. The porcine circovirus type 3 virus strain has good immunogenicity, and the vaccine composition prepared therefrom can provide full protection against porcine circovirus type 3 viruses from different origins.

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Номер записи: 8
26-02-2015 дата публикации

MACROLIDE COMPOUND

Номер: WO2015024298A1
Автор: LIU, Xingjin, ZHANG, Xuke
Принадлежит:

The present invention relates to a macrolide compound as shown by formula I and pharmaceutically acceptable salts thereof. The compound of the present invention is an antibacterial agent, and can be used to treat various bacterial and protozoal infections. The present invention further relates to the preparation method of the compound and a pharmaceutical composition thereof.

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Номер записи: 9
10-01-2013 дата публикации

C-3 SUBSTITUTED-9-DEOXIDIZED-9A-AZA-9A-ERYTHROMYCIN A DERIVATIVE

Номер: WO2013004116A1
Автор: LIU, Xingjin, ZHANG, Xuke
Принадлежит:

The present invention relates to a compound as represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 is H, hydroxyl or methoxyl; R2 is hydroxyl; R3 is heteroatom-substituted or unsubstituted organic matter, and the heteroatom is one or more of halogens, N, O and S; R4 is H, carbobenzoxy, benzoyl or acetyl. The compound of the present invention as represented by the general formula (I) is an antibacterial agent, and can be used for the treatment of various bacteria and protozoan infections. The present invention also relates to a use of the compound, a preparation method thereof and a composition formed therewith.

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Номер записи: 10
04-12-2014 дата публикации

PORCINE PSEUDORABIES VIRUS, VACCINE COMPOSITION AND PREPARATION METHOD AND USE THEREOF

Номер: WO2014190838A1
Автор: ZHANG, Xuke, SUN, Jinzhong, WU, Rui, TAN, Feifei, BAI, Chaoyong, TIAN, Kegong
Принадлежит:

Provided in the present invention is a vaccine composition comprising an immune amount of attenuated live vaccine, inactivated vaccine, subunit vaccine, synthetic vaccine, or genetically engineered vaccine of the porcine pseudorabies virus strain. The vaccine composition can effectively induce antibody generation, and prevent infections of virulent strains of the porcine pseudorabies virus, and provides effective protection for pigs.

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Номер записи: 11
04-10-2018 дата публикации

VACCINE COMPOSITION AND PREPARATION METHOD AND APPLICATION THEREOF

Номер: WO2018176837A1
Автор: TIAN, Kegong, CHENG, Yi, PANG, Wenqiang, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

The present invention provides a vaccine composition, comprising an immunological amount of egg drop syndrome virus Fiber protein or an immunological amount of live vector recombined with egg drop syndrome virus Fiber protein gene and a veterinarily acceptable carrier.

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Номер записи: 12
23-07-2020 дата публикации

FOOT-AND-MOUTH DISEASE VIRUS-LIKE PARTICLE ANTIGEN, AND VACCINE COMPOSITION, PREPARATION METHOD, AND APPLICATION THEREOF

Номер: WO2020147015A1
Автор: TIAN, Kegong, XIAO, Yan, PANG, Wenqiang, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

Provided is an O-type foot-and-mouth disease virus (FMDV)-like particle antigen; said O-type FMDV-like particle antigen is a CATHAY-type O-type FMDV-like particle antigen; said CATHAY-type O-type FMDV-like particle antigen is assembled from CATHAY-type O-type FMDV VP0, VP3, and VP1 antigen proteins. The O-type FMDV-like particle antigen has good immunogenicity, the prepared vaccine is administered once for immunity, and on the 14th day after immunization, complete protection against O-type FMDV is produced; the antibody titer produced is more potent than that of commercial inactivated vaccines, and the period of immune protection can be maintained for at least 133 days. Also provided are a prepared vaccine composition and preparation method and application thereof.

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Номер записи: 13
02-07-2020 дата публикации

IMMUNOLOGIC ADJUVANT COMPOSITION AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Номер: WO2020133817A1
Автор: TIAN, Kegong, LIU, Yongmei, ZHANG, Xuke
Принадлежит:

The present invention provides an adjuvant composition, containing 0.2%-0.5%w/v of Carbomer, 0.1%-0.5% w/v of lecithin and 0.03%-0.2%w/v of ginsenoside. The adjuvant composition of the present invention not only guarantees vaccines to be clarified and/or stabilized for a long time but also effectively stimulates inactivated antigens and subunit antigens in the vaccines to generate high-titer antibody for immune protection. Inactivated vaccines or subunit vaccines prepared by the adjuvant composition according to the present invention can be used as diluents for freeze-dried live-virus antigens, and have no toxic action on live-virus antigens.

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Номер записи: 14
05-01-2017 дата публикации

PORCINE PSEUDORABIES VIRUS SUBUNIT VACCINE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Номер: WO2017000470A1
Автор: TIAN, Kegong, WANG, Tongyan, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

Provided is a porcine pseudorabies virus gB protein fragment, or a conserved variant or an active fragment thereof. The gB protein fragment or gB and gD proteins can be used for preparing a subunit vaccine, thus achieving a protective effect against pseudorabies caused by porcine pseudorabies viruses.

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Номер записи: 15
27-06-2023 дата публикации

Vaccine composition for preventing echinococcosis as well as preparation method and application thereof

Номер: CN116327901A
Автор: TIAN KEGONG, WANG YANWEI, ZHANG XUKE
Принадлежит:

The invention provides a vaccine composition. The vaccine composition comprises fusion protein of SUMO-EG95 protein fragments in an immune dose or fusion protein of ELP40-SUMO-EG95 protein fragments in an immune dose, and a pharmaceutically acceptable carrier. The vaccine composition provided by the invention has a good immune effect, and can protect cattle and sheep from infection of echinococcosis. The preparation method can be used for industrial large-scale production and application.

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Номер записи: 16
25-02-2016 дата публикации

PORCINE PSEUDORABIES VIRUS GENE DELETION STRAIN, VACCINE COMPOSITION, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Номер: WO2016026264A1
Автор: TIAN, Kegong, ZHANG, Xuke, SUN, Jinzhong, TAN, Feifei
Принадлежит:

Provided is a porcine pseudorabies virus attenuated strain, which is a porcine pseudorabies virus variant with inactivated gI/gE/11K/28K protein. Also provided are a vaccine composition comprising porcine pseudorabies virus attenuated strain antigen, and a preparation method therefor and an application thereof.

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Номер записи: 17
15-08-2023 дата публикации

Breeding environment improver easy to clean, preparation method and application thereof

Номер: CN116585365A
Автор: ZHANG XUKE, LIU YAFEI, LI PENGPENG, LI HUANJUAN, ZHANG CONG, ZHANG WENJUN, HU HUIJUN
Принадлежит:

The invention relates to the field of environment improvers for livestock and poultry breeding, and discloses a breeding environment improver easy to clean, and a preparation method and application thereof. The breeding environment improver comprises the following components in percentage by weight: 25%-60% of montmorillonite, 20%-30% of zeolite powder, 8%-55% of a mineral adsorbent, 0%-1% of a detumescence agent and 0%-1% of a mosquito repellent, wherein the granularity of the zeolite powder is 100-200 meshes. The breeding environment improver disclosed by the invention can be daily used in livestock and poultry breeding, and has the advantages of easiness in site cleaning, reduction of environmental humidity and inhibition of bacterial reproduction, simple preparation method, easiness in operation and low cost.

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Номер записи: 18
27-12-2018 дата публикации

IMMUNOGENIC COMPOSITION COMPRISING PORCINE CIRCOVIRUS TYPE 3 AND PORCINE CIRCOVIRUS TYPE 2 ANTIGENS AND USE THEREOF

Номер: WO2018233264A1
Автор: TIAN, Kegong, YUAN, Yuren, LI, Xiangdong, YIN, Bo, XIAO, Yan, LU, Zhou, HU, Dongxue, SUN, Jinzhong, MO, Xiaobing, ZHANG, Xuke
Принадлежит:

Disclosed is an immunogenic composition containing porcine circovirus type 3 and porcine circovirus type 2 antigens, wherein the immunogenic composition comprises an immunological amount of a porcine circovirus type 3 antigen, an immunological amount of a porcine circovirus type 2 new gene subtype antigen and a pharmaceutically acceptable carrier. The immunogenic composition has good immunogenicity, and immunization with same just once can completely protect a subject from mixed infection by porcine circovirus type 3 and porcine circovirus type 2.

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Номер записи: 19
13-06-2023 дата публикации

African swine fever virus subunit vaccine composition and application thereof

Номер: CN116251179A
Автор: TIAN KEGONG, PANG WENQIANG, ZHANG XUKE
Принадлежит:

The invention provides an African swine fever virus subunit vaccine composition. The African swine fever virus subunit vaccine composition is prepared from the following components in immune dose: African swine fever virus p72 protein, p30 protein, p54 protein, African swine fever virus nucleocapsid assembly protein, African swine fever virus replication protein, African swine fever virus adsorption protein and African swine fever virus virulence protein, the African swine fever virus subunit vaccine composition further comprises a pharmaceutically acceptable carrier. The African swine fever virus subunit vaccine composition can provide good immune efficacy for pigs, protein antigens of the African swine fever virus subunit vaccine composition have a synergistic effect, and the African swine fever virus subunit vaccine composition can provide better immune efficacy under the condition of low total protein content.

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Номер записи: 20
29-09-2016 дата публикации

PORCINE PSEUDORABIES VIRUS ATTENUATING METHOD, VIRAL STRAINS ATTENUATED THEREBY, VACCINE COMPOSITION AND APPLICATION THEREOF

Номер: WO2016150026A1
Автор: TIAN, Kegong, TAN, Feifei, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

Provided is a porcine pseudorabies virus attenuating method. The method can effectively and reproducibly attenuate porcine pseudorabies viruses, and porcine pseudorabies virus-attenuated viral strains attenuated by the method can provide effective immunity for swine.

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Номер записи: 21
04-01-2018 дата публикации

VACCINE COMPOSITION FOR PREVENTING PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME, PREPARATION METHOD THEREFOR AND USE THEREOF

Номер: WO2018000722A1
Автор: ZHANG, Xuke, SUN, Jinzhong, TIAN, Kegong, ZHANG, Haiyang
Принадлежит:

Provided is a vaccine composition for the prevention of porcine reproductive and respiratory syndrome. The vaccine composition comprises an immunologically effective amount of a classical porcine reproductive and respiratory syndrome virus antigen and/or a highly pathogenic porcine reproductive and respiratory syndrome virus antigen and/or porcine reproductive and respiratory syndrome virus NADC30-like strain antigen, and a pharmaceutically acceptable carrier.

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Номер записи: 22
07-06-2018 дата публикации

VACCINE COMPOSITION, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Номер: WO2018099244A1
Автор: TIAN, Kegong, PANG, Wenqiang, SUN, Jinzhong, ZHANG, Xuke
Принадлежит:

Disclosed is a vaccine composition. The vaccine composition comprises an immune amount of fowl adenovirus Fiber-2 protein or an immune amount of live vector where fowl adenovirus Fiber-2 protein gene is recombined, and a pharmaceutically-acceptable carrier.

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Номер записи: 23
25-07-2023 дата публикации

Preparation method of fluralana intermediate

Номер: CN116478057A
Автор: ZHANG XUKE, GUO XIAOXING, HOU LIN
Принадлежит:

The preparation method comprises the following steps: acetylating amino of a compound shown in a formula I in a solvent to obtain a compound shown in a formula II; carrying out Friedel-Crafts acylation reaction on the compound shown as the formula II in a solvent to obtain a compound shown as a formula III; dissolving the compound as shown in the formula III in acid for hydrolysis to obtain a compound as shown in a formula IV; dissolving the compound as shown in the formula IV in acid, carrying out diazotization reaction to obtain diazonium salt, and then carrying out cyano substitution on the diazonium salt to obtain a compound as shown in a formula V; dissolving the compound as shown in the formula V in acid to carry out cyano hydrolysis reaction so as to obtain a compound as shown in a formula VI; and in the presence of a catalyst, esterifying the compound shown in the formula VI in a solvent to obtain the fluralana intermediate 4-acetyl-2-methyl methyl benzoate. According to the method ...

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Номер записи: 24
25-08-2023 дата публикации

Flurala soft chewing composition, soft chewing tablet and preparation method and application of flurala soft chewing composition and soft chewing tablet

Номер: CN116637078A
Автор: ZHANG XUKE, ZHANG WENJUN, LI HUANJUAN, SHI MENGCHAO
Принадлежит:

The invention relates to a fluralan soft chewing composition with good palatability, a soft chewing tablet and a preparation method and application of the fluralan soft chewing composition and the soft chewing tablet. The flurala soft chewing composition comprises flurala, corn starch, soybean protein powder, chicken liver powder, hydroxy propyl cellulose, polyethylene glycol 3350, polyethylene glycol 15 hydroxy stearate, glycerol and soybean oil. The fluralab soft chewing composition, especially the soft chewing tablet, prepared according to the application is stable in property, good in palatability, simple in preparation method and suitable for large-scale production and clinical application.

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Номер записи: 25
22-08-2023 дата публикации

Ointment matrix and preparation method, product and application thereof

Номер: CN116617153A
Автор: ZHANG XUKE, SHI MENGCHAO, LI HUANJUAN, ZHANG WENJUN
Принадлежит:

The invention relates to the field of medicines, in particular to an ointment matrix as well as a preparation method, a product and application thereof. The ointment base provided by the invention comprises 80.0% w/w to 88.5% w/w of liquid paraffin, 4.5% w/w to 10% w/w of polyethylene wax, 3.5% w/w to 6.0% w/w of a surfactant and 2.0% w/w to 4.0% w/w of an emollient. The ointment matrix is stable and not layered, does not interfere with skin functions, is easy to clean and does not pollute skin and hair, meanwhile, the preparation process is simple, and the requirements of saving materials, reducing cost and being easy to industrialize are met.

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Номер записи: 26
30-06-2023 дата публикации

Anti-canine parvovirus mouse-canine chimeric antibody, cell line expressing same, prepared pharmaceutical preparation and application of anti-canine parvovirus mouse-canine chimeric antibody

Номер: CN116355855A
Автор: TIAN KEGONG, TAN FEIFEI, ZHANG XUKE
Принадлежит:

The invention provides a recombinant CHO cell line expressing an anti-canine parvovirus mouse/canine chimeric antibody, and the expressed anti-canine parvovirus mouse/canine chimeric antibody. The chimeric antibody has high neutralizing activity to canine parvovirus, and reduces immunological rejection to mouse antibodies. A pharmaceutical preparation prepared from the chimeric antibody can effectively treat canine parvovirus infection.

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Номер записи: 27
06-06-2023 дата публикации

Suspended disinfectant as well as preparation method and application thereof

Номер: CN116210696A
Автор: ZHANG XUKE, LI PENGPENG
Принадлежит:

The invention relates to a suspension disinfection mode which comprises a suspension disinfectant and a preparation method and application thereof. The suspension disinfectant is prepared from the following components in percentage by weight: 10 percent of decyl methyl ammonium bromide, 5 to 15 percent of diethylene glycol, 10 to 25 percent of propylene glycol, 10 to 25 percent of glycerol, 0.01 to 0.05 percent of OP-10, 0.1 to 0.5 percent of nonylphenol polyoxyethylene ether, 0.1 to 0.5 percent of fatty alcohol-polyoxyethylene ether, 2 to 10 percent of ethanol, 0.1 to 0.5 percent of EDTA (Ethylene Diamine Tetraacetic Acid) and 0 to 0.15 percent of lemon essential oil. The suspension disinfection mode is excellent in suspension performance, high in safety, good in stability, non-toxic and pollution-free, can be used for space disinfection of livestock and poultry houses, and can also be directly used for disinfection of environments, articles and the like.

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Номер записи: 28
14-07-2023 дата публикации

Preparation method of fluralana, novel crystal form of fluralana, and preparation method and application of novel crystal form of fluralana

Номер: CN116425693A
Автор: ZHANG XUKE, GUO XIAOXING, HOU LIN, YUAN SHUXIA
Принадлежит:

According to the preparation method of the fluralan, the intermediate 1 is prepared through catalysis of the ionic liquid, the intermediate 2 is obtained through one-step reaction by adopting a high-boiling-point solvent and appropriate alkali in the process of preparing the intermediate 2 from the intermediate 1, a dehydration process is avoided, and the method is simple, convenient and easy to operate. The preparation of the intermediate 2 and the intermediate 3 is a key control process step, in the process of preparing the isoxazole intermediate through hydroxylamine hydrochloride cyclization, sensitive groups including ester groups, carboxyl groups and the like are replaced with halogens, side reaction with hydroxylamine hydrochloride is avoided, introduction of impurities is reduced, and the process is easy for industrial production. The purity reaches 99.95% after one-time recrystallization. In addition, the invention also provides a new crystal form of fluralaner and a preparation ...

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Номер записи: 29