23-06-2023 дата публикации
Номер: CN116297902A
Принадлежит:
The invention discloses a method for detecting the concentration of carbamazepine in human plasma by establishing a UPLC-Orbitrap-MS (Ultra Performance Liquid Chromatography-Orbitrap-Mass Spectrometry) method, and relates to the technical field of quantitative detection of carbamazepine. According to the method, an ultrahigh performance liquid chromatography-Orbitrap-mass spectrum combined detection method is adopted. Comprising the following steps: S1, setting chromatographic conditions; s2, determining mass spectrum conditions; s3, preparation of an STD-Stock-20211012 stock solution is carried out, and the S4, preparing a standard curve working solution; s5, preparation of a quality control stock solution of QC1-Stock-20211012 (QC1-Stock-20211012 S6, preparing a quality control working solution; s7, preparation of a loratadine stock solution IS-Stock-20211012, and preparation of the loratadine stock solution S8, preparation of a secondary loratadine stock solution IS-SubStock; s9, preparing ...
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