07-04-2023 дата публикации
Номер: CN115925753A
Принадлежит:
The invention discloses a method for rapidly synthesizing a ferrocene phenanthridine compound, which comprises the following steps of: uniformly stirring ferrocene oxime 1 serving as a starting raw material in a solvent at room temperature, slowly dropwise adding diethyl zinc in an ice-water bath, stirring a reaction system at room temperature for 5-10 minutes after dropwise adding is completed, filtering, washing and drying to obtain the ferrocene phenanthridine compound. Then adding an ether solution of an aryl Grignard reagent 2, and reacting at 100 DEG C; after a TLC point plate monitors that the raw materials completely react, dropwise adding an ammonium chloride saturated aqueous solution into a reaction system for quenching reaction, then adding ethyl acetate for extraction, combining organic phases, drying sodium sulfate, carrying out rotary evaporation to remove an organic solvent to obtain a crude product, and separating and purifying to obtain a target product 3. Transition metal ...
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