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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

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Применить Всего найдено 8. Отображено 8.
25-11-2010 дата публикации

ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS

Номер: KR2010134790A2
Автор: JI, Young-Hoon, KIM, Dong-Hee, KANG, Jae-Seon, KIM, Chun-Gyu, CHUNG, Sung-Uk, HWANG, Sung-Woo, KANG, Kyung-Ran
Принадлежит:

The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and growth of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), which is a pro-inflammatory cytokine, interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF). Therefore, ...

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Номер записи: 1
07-03-2017 дата публикации

NOVEL COMPOUND, 4-ETHYL-7-(2-FLUORO-BENZYLSULFANYL)-2-METHYL-1-THIA-3B,5,6-TRIAZA-CYCLOPENTA[A]INDENE, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR ANTI-CANCER DRUG

Номер: KR1020170024194A
Автор: JEON, SUN DUCK, HWANG, SUNG WOO, PARK, SU YOUNG, KANG, KYUNG RAN, BIN, HYE RIN, JI, YOUNG HOON, YOON, SUK KYOON, KIM SEONG HEON, KIM, NAM DOO, LEE, SUNG WOO, LEE, SANG KWANG
Принадлежит:

The present invention relates to a novel compound represented by chemical formula 1 and a pharmaceutical composition comprising the same for an anti-cancer drug having an excellent anti-cancer effect. Typical examples of cancers that can be prevented or treated by the pharmaceutical composition according to the present invention include uterine cancer, breast cancer, stomach cancer, brain cancer, colon/rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, oral cancer, prostate cancer, ovarian cancer, thyroid cancer, gallbladder cancer, bladder cancer, kidney cancer, larynx cancer, pharynx cancer and liver cancer. The pharmaceutical composition may comprise an anti-cancer drug and conventional pharmaceutical additives. A pharmaceutical preparation comprising the compound may be provided in any formulation, such as a tablet, powder, granule, injection or liquid. The dose of the pharmaceutical composition comprising the compound of chemical formula 1 according to the present ...

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Номер записи: 2
25-11-2010 дата публикации

ANTI-INFLAMMATORY COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS

Номер: WO2010134790A3
Автор: JI, Young-Hoon, KIM, Dong-Hee, KANG, Jae-Seon, KIM, Chun-Gyu, CHUNG, Sung-Uk, HWANG, Sung-Woo, KANG, Kyung-Ran
Принадлежит:

The present invention relates to an anti-inflammatory use of macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A, which are produced from a novel Bacillus strain of Bacillus polyfermenticus KJS-2 (KCCM10769P). The macrolactin compounds provided by the present invention were confirmed to greatly suppress the expression and growth of inducible nitric oxide synthetase (iNOS) and cyclooxygenase-2 (COX-2) which are proteins related to the formation of inflammatory mediators, and to accordingly inhibit the formation of nitric oxide (NO) and of prostaglandin E2 (PGE2) which are the metabolites of the proteins. In addition, the macrolactin compounds provided by the present invention were confirmed to have excellent effects in inhibiting the formation of tumor necrosis factor-alpha (TNF-α), which is a pro-inflammatory cytokine, interleukin-1β (IL-1β), interleukin-6 (IL-6) and granulocyte macrophage colony-stimulating factor (GM-CSF). Therefore, ...

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Номер записи: 3
02-03-2017 дата публикации

TRIAZOLE DERIVATIVES AND ANTICANCER DRUG PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: WO2017034294A1
Автор: JEON, Sun Duck, HWANG, Sung Woo, PARK, Su Young, KANG, Kyung Ran, BIN, Hye Rin, JI, Young Hoon, YOON, Suk Kyoon, KIM, Seong Heon, KIM, Nam Doo, LEE, Sung Woo, LEE, Sang Kwang
Принадлежит:

The present invention relates to 4-ethyl-7-(2-fluoro-benzylsulfanyl)-2-methyl-1-thia-3b,5,6-triaza-cyclopenta[a]indene of chemical formula 1, and an anticancer drug pharmaceutical composition having excellent anticancer effects and containing the same.

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Номер записи: 4
13-02-2017 дата публикации

METHOD FOR TRANSFERRING SECURE MESSAGE BY USING NULL SPACE IN MANET ENVIRONMENT AND SYSTEM THEREOF

Номер: KR101699434B1
Автор: RYU, DONG KUK, KIM, HYUNG JIN, KANG, KYUNG RAN, CHO, YOUNG JONG
Принадлежит: AGENCY FOR DEFENSE DEVELOPMENT

The present invention relates to a message transmission technique in network communication, and more particularly, to a method for transferring a secure message and a system thereof using a null space in a mobile ad hoc networks (MANET) environment. The method includes a step of performing an initialization phase, a step of performing an upstream phase, and a step of performing a downstream phase. COPYRIGHT KIPO 2017 ...

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Номер записи: 5
19-01-2016 дата публикации

Analgesic and antipyretic compositions containing Decursinol derivatives

Номер: KR0101585450B1
Автор: 황성우, 김동희, 강경란, 김성, 지용훈, 정성욱, 강재선, 김천규
Принадлежит: 대우제약 주식회사

... 본 발명은 해열 및 진통 효과가 우수한 Decursinol 유도체를 함유하는 약학 조성물에 관한 것으로, 본 발명에 따른 해열 및 진통제 조성물은 유효성분으로서 하기 화학식 1로 표시되는 Decrusinol(이하 데커시놀)의 유도체인(7S)-butanedioic acid-8,8-dimethyl-2-oxo-6,7-dihydro-2H, 8H-pyrano[3,2-g]chromen-7-yl-ester(이하 숙시닐 데커시놀)과(7S)-acetic acid- 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester(이하 아세틸 데커시놀)을 포함한다. 화학식1 상기 식에서 R은 수소, (7S)-butanedioic acid, 또는 (7S)-acetic acid 이다.

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Номер записи: 6
09-03-2017 дата публикации

신규 화합물 4-Ethyl-7-(2-fluoro-benzylsulfanyl)-2-methyl-1-thia-3b, 5, 6-triaza-cyclopenta[a]indene 및 이를 포함하는 항암제용 약제학적 조성물

Номер: KR0101713678B1
Автор: 전선덕, 황성우, 박수영, 강경란, 빈혜린, 지용훈, 윤석균, 김성헌, 김남두, 이성우, 이상광
Принадлежит: 대우제약 주식회사

... 본 발명은 신규한 화학식 1 화합물 및 상기 화합물을 포함하는 항암 효과가 우수한 항암제용 약제학적 조성물에 관한 것이다. 본 발명의 약제학적 조성물에 의해 예방 또는 치료될 수 있는 암은 자궁암, 유방암, 위암, 뇌암, 결장/직장암, 췌장암, 대장암, 폐암, 피부암, 혈액암, 구강암, 전립선암, 난소암, 갑상선암, 담낭암, 방광암, 신장암, 후두암, 인두암 및 간암 등이며, 항암제 및 통상의 의약 첨가제들을 포함할 수 있다. 이 화합물을 약학 제제는 정제, 산제, 과립제, 주사제, 액제 등의 모든 제형에 사용이 가능하며, 본 발명의 화합물 1의 약학 조성물의 사용량은 환자의 나이, 성별, 체중 등에 따라 달라질 수 있으나, 0.01 내지 1000 ㎎/㎏의 양을 1일 1 회 내지 수 회로 나누어 투여할 수 있다. 화학식 1 ...

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Номер записи: 7
19-01-2012 дата публикации

ANTI-ANGIOGENIC COMPOSITION CONTAINING MACROLACTIN A AND A DERIVATIVE THEREOF AS ACTIVE INGREDIENTS

Номер: KR2012008674A1
Автор: JI, Young-Hoon, KIM, Dong-Hee, KIM, Jung-Ae, KANG, Jae-Seon, CHUNG, Sung-Uk, HWANG, Sung-Woo, KANG, Kyung-Ran, KANG, You-Ra
Принадлежит:

The present invention relates to an anti-angiogenic composition containing macrolactin compounds such as macrolactin A, 7-O-malonyl macrolactin A, and 7-O-succinyl macrolactin A as active ingredients. The macrolactin compounds according to the present invention strongly suppress angiogenesis in in vivo experiments, and can be used as a pharmaceutical composition for preventing or treating diseases caused by angiogenesis.

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Номер записи: 8