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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 56. Отображено 56.
14-11-2019 дата публикации

METHOD FOR GENERATING INDUCED NEURAL STEM CELLS DIRECTLY REPROGRAMMED FROM NON-NEURAL CELLS BY USING SOX2 AND C-MYC

Номер: WO2019216667A9
Автор: KANG, Kyung-Sun, SEO, Kwang Won, KWON, Daekee, JEE, Min-Jun, HAN, Mi-Jung, AHN, Hee-Jin
Принадлежит:

The present invention relates to a method for generating neural stem cells induced from non-neural cells through direct reprogramming and a use thereof. Because the method for generating induced neural stem cells according to the present invention allows the generation of induced neural stem cells from non-neural cells even when only the two inducing factors Sox2 and c-Myc are used, the method can generate induced neural stem cells more effectively than conventional generation methods using four or five inducing factors. The induced neural stem cells generated by the method exhibit excellent differentiation potency and proliferation activity and thus can be applied to therapeutic purposes in future.

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Номер записи: 1
25-08-2011 дата публикации

CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY

Номер: WO2011102680A9
Автор: KANG, Kyung Sun, YU, Kyung Rok
Принадлежит:

The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient. According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesion culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.

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Номер записи: 2
09-10-2014 дата публикации

METHOD FOR PRODUCING REPROGRAMMED DERIVATIVE NEURONAL STEM CELL FROM NON-NEURONAL CELL BY USING HMGA2

Номер: WO2014163425A1
Автор: KANG, Kyung Sun, YU, Kyung Rok
Принадлежит:

The present invention relates to a method for producing a reprogrammed derivative neuronal stem cell from a differentiated cell. A method for producing a derivative neuronal stem cell according to the present invention can produce a derivative neuronal stem cell from a non-neuronal cell only by using two derivative factors of SOX2 and HMGA2, and so is more effective compared to the conventional method using 4 derivative factors or 5 derivative factors. Also the method considerably enhances the derivation efficiency and proliferation capability compared to the method using only one derivative fact of SOX2, thus enlarging the applicability of the stem cell to treating diseases.

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Номер записи: 3
20-07-2017 дата публикации

STEM CELL-DERIVED EXOSOME CONTAINING HIGH AMOUNT OF GROWTH FACTORS

Номер: WO2017123022A1
Автор: KANG, Kyung Sun, SEO, Kwang Won, KIM, Yu Lee, KIM, Yoon Jin
Принадлежит:

The present invention relates to an exosome having an increased amount of growth factors and obtained from stem cells cultured in a medium containing an epithelial growth factor (EGF) and/or a fibroblast growth factor (FGF). It is considered that the exosome separated from a stem cell culture liquid penetrates into a skin dermal layer in a nano-sized form and increases a regenerative effect. In addition, the exosome contains a great amount of various growth factors, thereby having effects of skin regeneration and anti-aging through the proliferation and activation of fibroblasts, which are skin component cells, and effects of collagen synthesis promotion, hair growth, contracted hair follicle restoration and wound healing.

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Номер записи: 4
25-07-2016 дата публикации

퇴행성 뇌질환을 예방, 개선 또는 치료하는 유황의 법제 방법 및 상기 방법으로 법제된 유황

Номер: KR0101642113B1
Автор: 김성철, 강경선, 장성태
Принадлежит: 원광대학교산학협력단, 주식회사 강스템바이오텍

... 본 발명은 퇴행성 뇌질환을 예방, 개선 또는 치료하는 유황의 법제 방법 및 상기 방법으로 법제된 유황에 관한 것으로서, 구체적으로는 유황을 녹이는 단계; 유황을 고체화하는 단계; 및 유황을 건조하는 단계를 복수 회 반복 수행한 후, 유황을 땅에 묻어 보관하는 단계; 및 유황을 생강물로 찌는 단계를 포함하는 유황 법제 방법 및 상기 방법으로 법제한, 퇴행성 뇌질환을 예방, 개선 또는 치료하는 유황에 관한 것이다. 본 발명에 따른 방법으로 법제된 유황은 HT22 세포에서 산화적 스트레스를 감소시켜 세포 생존률을 증진하는 효능 및 BV2 세포에서 LPS 첨가로 유도된 염증매개물질인 나이트리트를 감소시키는 효능을 보유하고 있다.

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Номер записи: 5
18-09-2017 дата публикации

METHOD FOR GENERATING INDUCED NEURAL STEM CELL USING NON-NEURONAL CELL

Номер: KR101778953B1
Автор: KANG, KYUNG SUN, CHOI, SOON WON, SHIN, JI HEE, LEE, SEUNG HEE
Принадлежит: KANGSTEM BIOTECH CO., LTD., SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

The present invention relates to a composition for inducing conversion of non-neuronal cells into induced neural stem cells, a kit for inducing conversion of non-neuronal cells into induced neural stem cells including the composition, a method for generating induced neural stem cells converted from non-neuronal cells using the composition or the kit and the induced neural stem cells generated by the method. By using the method for converting non-neuronal cells into induced neural stem cells of the present invention, normal non-neuronal cells can be converted into induced neural stem cells without modification of gene, thereby being widely used for a method for treating various nerve disorders using autologous neural stem cells. COPYRIGHT KIPO 2017 ...

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Номер записи: 6
20-12-2017 дата публикации

GDF11을 포함하는 조성물 및 그의 용도

Номер: KR0101810385B1
Автор: 김윤진, 이승희, 서광원, 강경선
Принадлежит: 주식회사 강스템바이오텍

... 본 발명은 GDF11 또는 이를 포함하는 인간 유래 성체 줄기세포 배양액을 포함하는 피부재생용 약학 조성물, 주름개선용 약학 조성물, 창상 치료용 약학 조성물, 피부재생용 의약외품 조성물, 주름개선용 의약외품 조성물, 창상 치료용 의약외품 조성물, 피부재생용 화장료 조성물, 주름개선용 화장료 조성물, 창상 개선용 화장료 조성물, 섬유아세포 배양용 배지 조성물, 상기 배지 조성물을 이용하여 섬유아세포를 배양하는 방법 및 상기 줄기세포를 배양하여 GDF11을 제조하는 방법에 관한 것이다. 본 발명에서 제공하는 GDF11은 인간 유래 성체 줄기세포 배양액에 포함되어 섬유아세포의 증식을 촉진시키는 효과를 나타내므로, 보다 다양한 피부재생용, 주름개선용 또는 창상 치료용 제품의 개발에 널리 활용될 수 있을 것이다.

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Номер записи: 7
15-01-2018 дата публикации

CARTILAGE DIFFERENTIATION PROMOTING COMPLEX INCLUDING STEM CELL AND CARTILAGE-FREE CELL LYSATE AND USE THEREOF

Номер: KR1020180005130A
Автор: KANG, KYUNG SUN, SEO, KWANG WON, YOON, KYUNG AE, JEON, HYO JIN, SIM, YUN BEOM
Принадлежит:

The present invention relates to a cartilage differentiation promoting complex including stem cells or a culture of the stem cells and cartilage-free cell lysates, a cartilage preparing method using the complex, a cartilage tissue prepared by using the method, a pharmaceutical composition including the complex for prevention or treatment of joint diseases, a method for prevention or treatment of joint diseases using the composition, a cartilage cell differentiation promoting complex including the prepared cartilage cells, and a method for preparing the cartilage tissue by using the prepared cartilage cells. According to the present invention, the cartilage differentiation promoting complex including stem cells or a culture of the stem cells and cartilage-free cell lysates can differentiate to cartilage cells without causing side effects in vivo while promoting the differentiation of mesenchymal stem cells in vivo to the cartilage cells by using the paracrine effects exhibited in differentiated ...

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Номер записи: 8
31-03-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF IMMUNE DISEASES OR INFLAMMATORY DISEASES, COMPRISING STEM CELL TREATED WITH MAST CELL GRANULES OR CULTURE THEREOF

Номер: WO2016048052A1
Автор: KIM, Hyung Sik, LEE, Byung Chul, SEO, Kwang Won, KANG, Kyung Sun
Принадлежит:

The present invention relates to a pharmaceutical composition for prevention or treatment of immune diseases or inflammatory diseases, comprising a stem cell incubated by adding mast cell granules or a culture thereof to a stem cell.

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Номер записи: 9
29-08-2013 дата публикации

COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS AS ACTIVE INGREDIENT

Номер: WO2013125899A1
Автор: KANG, Kyung Sun, LEE, Sung Hoon
Принадлежит:

The present invention relates to: a composition for preventing or treating immune diseases or inflammatory diseases, containing stem cells or a cultured product thereof; and a method for preparing the composition. Stem cells, a cultured product thereof, or stem cells cultured by adding a NOD2 agonist of the present invention can be effectively used to prevent or treat immune diseases or inflammatory diseases including atopic dermatitis.

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Номер записи: 10
21-07-2011 дата публикации

PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER, CONTAINING AN EXTRACELLULAR MATRIX OF MESENCHYMAL STEM CELLS DERIVED FROM UMBILICAL CORD BLOOD AS AN ACTIVE INGREDIENT

Номер: KR2011087299A2
Автор: KANG, Kyung sun
Принадлежит:

The present invention relates to a pharmaceutical composition for the treatment of cancer, containing an extracellular matrix (ECM) of mesenchymal stem cells derived from umbilical cord blood as an active ingredient, and more specifically, to a pharmaceutical composition for the treatment of cancer, containing an ECM as an active ingredient, obtained by culturing mesenchymal stem cells derived from umbilical cord blood and removing only cells. The ECM of mesenchymal stem cells derived from umbilical cord blood may suppress the proliferation of various cancers, such as breast cancer, melanoma, pancreatic cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, etc. and minimize problems in manufacturing pharmaceutical or individual deviations when stem cells are used. In addition, side effects, which may occur from the in vivo injection of cells, may be fundamentally prevented.

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Номер записи: 11
10-08-2017 дата публикации

COMPOSITION CONTAINING GDF11 AND USE THEREOF

Номер: WO2017135556A1
Автор: KIM, Yoon Jin, LEE, Seung Hee, SEO, Kwang Won, KANG, Kyung Sun
Принадлежит:

The present invention relates to: a pharmaceutical composition for skin regeneration, a pharmaceutical composition for improving wrinkles, a pharmaceutical composition for treating wounds, a quasi-drug composition for skin regeneration, a quasi-product composition for improving wrinkles, a quasi-drug composition for treating wounds, a cosmetic composition for skin regeneration, a cosmetic composition for improving wrinkles, a cosmetic composition for improving wounds, and a medium composition for culturing fibroblasts which contain GDF11 or a human-derived adult stem cell culture fluid comprising the same; a method for culturing fibroblasts by using the medium composition; and a method for producing GDF11 by culturing the stem cell. GDF11 provided in the present invention has an effect of promoting the proliferation of fibroblasts by being contained in a human-derived adult stem cell culture fluid, and thus can be widely utilized for development of a product for skin regeneration, wrinkle ...

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Номер записи: 12
26-06-2018 дата публикации

HMGA2를 이용하여 비신경 세포로부터 리프로그래밍된 유도 신경줄기세포를 제조하는 방법

Номер: KR0101870125B1
Автор: 강경선, 유경록
Принадлежит: 주식회사 강스템바이오텍, 서울대학교 산학협력단

... 본 발명은 분화된 세포로부터 리프로그래밍된 유도 신경줄기세포를 제조하는 방법에 관한 것이다. 본 발명에 의한 유도 신경 줄기세포의 생산 방법은 유도 인자로서 SOX2와 HMGA2의 2개 유도인자만을 이용하여도 비신경 세포로부터 유도 신경줄기세포를 제작할 수 있기 때문에, 기존의 4개의 인자, 5개의 유도인자를 이용한 생산 방법보다 더 효율적인 유도 신경 줄기세포를 제작할 수 있다. 또한 SOX2 유전자 1개만을 도입하였을 때보다 유도 효율 및 증식력이 현저히 우수하므로 치료 목적으로 활용가능성이 더 높아질 수 있다.

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Номер записи: 13
18-04-2016 дата публикации

METHOD FOR DETOXIFYING SULFUR FOR PREVENTION, IMPROVEMENT OR TREATMENT OF NEURODEGENERATIVE DISEASE AND SULFUR DETOXIFIED THEREBY

Номер: KR1020160041650A
Автор: KIM, SUNG CHUL, KANG, KYUNG SUN, JANG, SEONG TAE
Принадлежит:

The present invention relates to a method for detoxifying sulfur for prevention, improvement or treatment of neurodegenerative diseases and sulfur detoxified thereby. The present invention relates to a method for detoxifying sulfur, including the steps of: repeating dissolution of sulfur, solidification of sulfur and drying of sulfur multiple times, and burying and storing sulfur in the ground; and steaming sulfur with water containing ginger, and sulfur for prevention, improvement or treatment of neurodegenerative diseases, detoxified by the method. Sulfur detoxified by the method has an effect of reducing oxidative stress in HT22 cells to increase cell viability and an effect of reducing nitrite, an inflammation-mediating material derived by addition of LPS, in BV2 cells. COPYRIGHT KIPO 2016 (AA) Dietary processed sulfur ...

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Номер записи: 14
05-12-2019 дата публикации

HLA GENE-DELETED, HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED MESENCHYMAL STEM CELL AND PREPARATION METHOD THEREFOR

Номер: WO2019231266A1
Автор: KANG, Kyung-Sun, SEO, Kwang Won, AHN, Hee-Jin, KWON, Daekee, HAN, Mi-Jung
Принадлежит:

The present invention relates to a method for preparing induced pluripotent stem cells (iPSC) and embryonic stem cells (ESC), both the cells having a reduced expression level of HLA, which is a cause of immune rejection upon transplantation of cells, tissues, and organs, a method for preparing mesenchymal stem cells (MSC) by using the novel differentiation method of iPSC, and a cell therapy product using the iPSC, ESC, and/or MSC. Using the HLA gene-deleted MSC prepared in the present invention, various kinds of cells that do not cause immune rejection can be prepared, and they can be used for therapeutic purposes in future.

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Номер записи: 15
23-03-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING, AS ACTIVE INGREDIENT, STEM CELLS OVEREXPRESSING SOD3

Номер: WO2017048097A1
Автор: KANG, Kyung Sun, KIM, Tae Yoon
Принадлежит:

The present invention provides a pharmaceutical composition for preventing or treating inflammatory diseases, containing, as an active ingredient, stem cells overexpressing SOD3. The present inventor has ascertained that mesenchymal stem cells (MSCs) overexpressing SOD3 have a stronger antioxidant activity and immune regulatory function than normal MSCs, and thus the MSCs overexpressing SOD3 can be an effective treatment agent for inflammatory diseases, autoimmune diseases, organ transplant rejection and the like.

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Номер записи: 16
23-09-2010 дата публикации

METHODS FOR ISOLATING AND MASS CULTURE OF UMBILICAL CORD BLOOD STEM CELLS EXPRESSING ZNF281

Номер: KR2010107159A1
Автор: KANG, Kyung Sun, ROH, Kyoung Hwan
Принадлежит:

The present invention relates to a stem cell separation method characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and harvesting stem cells from culture; umbilical cord blood stem cells isolated thereby; and a cell therapeutic agent containing the stem cells or differentiated cells therefrom. In addition, the present invention relates to a novel culture medium for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture medium, and a method for increasing stemness of stem cells characterized by sphere culture or three-dimensional culture of stem cells.

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Номер записи: 17
06-10-2011 дата публикации

METHOD FOR INHIBITING THE SENESCENCE OF ADULT STEM CELLS BY INHIBITING MIRNA EXPRESSION

Номер: WO2011122889A3
Автор: KANG, Kyung Sun
Принадлежит:

The present invention relates to a method for inhibiting the senescence of adult stem cells, and more particularly, to a method for inhibiting the senescence of adult stem cells, in which the expression of any one selected from a group consisting of miRNA-23a, miRNA-26a, and miRNA-30a, which are expressed in adult stem cells, is inhibited by a specific inhibitor, to thereby increase the expression of high mobility group A2(HMGA2) and decrease the expression of p16 or p21, thus inhibiting the senescence of adult stem cells. The method for inhibiting the senescence of adult stem cells according to the present invention solves the problem of cell senescence being accelerated as subculturing is performed during adult stem cell culturing, causing a rapid decrease in cell division. The method of the present invention can maintain adult stem cells that preserve differentiation potency and cell regenerative capacity over a prolonged period of time, and thus can ensure an increased number of cells ...

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Номер записи: 18
30-05-2013 дата публикации

EQUINE AMNIOTIC MEMBRANE-DERIVED MESENCHYMAL STEM CELLS

Номер: WO2013077639A1
Автор: KANG, Kyung Sun, SEO, Min Soo, PARK, Sang Bum
Принадлежит:

The present invention relates to equine amniotic membrane-derived mesenchymal stem cells (eAM-MSCs) and a method for producing same. More particularly, the present invention relates to equine amniotic membrane-derived mesenchymal stem cells showing negative immunological properties on human markers CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P, and CD200, and also showing positive immunological properties on human markers CD44, CD90 and CD105. In addition, the present invention relates to equine amniotic membrane-derived mesenchymal stem cells that can be subcultured up to 14 or more times in an undifferentiated state and an ability to be differentiated into ectoblast, mesoblast and endoblast-derived cells.

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Номер записи: 19
10-10-2017 дата публикации

COMPOSITION CONTAINING GDF11, AND USE THEREOF

Номер: KR1020170110059A
Автор: KIM, YOON JIN, LEE, SEUNG HEE, SEO, KWANG WON, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a pharmaceutical composition for skin regeneration containing GDF 11 or a culture solution of human-derived adult stem cells containing the same. The present invention further relates to a pharmaceutical composition for wrinkle amelioration, a pharmaceutical composition for treating wounds, a quasi-drug composition for skin regeneration, a quasi-drug composition for wrinkle amelioration, a quasi-drug composition for treating wounds, a cosmetic composition for skin regeneration, a cosmetic composition for wrinkle amelioration, a cosmetic composition for ameliorating wounds, and a medium composition for culturing fibroblast. Moreover, the present invention relates to a method for culturing fibroblast using the medium composition, and a method for producing GDF11 by culturing the stem cells. GDF11 provided in the present invention is contained in the culture solution for human-derived adult stem cells, and promotes proliferation of fibroblast, thereby being ...

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Номер записи: 20
16-08-2017 дата публикации

COMPOSITIONS COMPRISING GDF11 AND USES THEREOF

Номер: KR1020170093283A
Автор: KIM, YOON JIN, LEE, SEUNG HEE, SEO, KWANG WON, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a pharmaceutical composition for skin regeneration, a pharmaceutical composition for reducing wrinkles, a pharmaceutical composition for treating wounds, a quasi-drug composition for skin regeneration, a quasi-drug composition for reducing wrinkles, a quasi-drug composition for treating wounds, a cosmetic composition for skin regeneration, a cosmetic composition for reducing wrinkles, a cosmetic composition for alleviating wounds, and a medium composition for culturing fibroblasts, a method for culturing fibroblasts by using the medium composition, and a method for producing GDF11 by culturing the stem cells, wherein all of the compositions comprise GDF11 or human-originated adult stem cells including the same. According to the present invention, GDF11 provided in the present invention has an effect of promoting the proliferation of fibroblasts when contained in culture fluid for human-originated adult stem cells, and thus can be widely utilized in the development ...

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Номер записи: 21
01-03-2012 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURED PRODUCT THEREOF

Номер: WO2012026712A4
Автор: KANG, Kyung Sun, KIM, Hyung Sik
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing the stem cells which are obtained by adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, or cultured product thereof, and more specifically, to a method for suppressing the immune diseases or inflammatory diseases of a subject, comprising the step of administering the pharmaceutical composition, the stem cell or a cultured product thereof to a subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or a cultured product thereof, a method for preparing PGE2 or TGF-β1, comprising the step of adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, a graft comprising stem cells which express NOD2 and an NOD2 agonist, a preparation method of the graft, a composite comprising stem cells which express NOD2 and an NOD2 agonist, and a cultured ...

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Номер записи: 22
23-09-2010 дата публикации

ISOLATING METHOD FOR UMBILICAL CORD BLOOD-DERIVED PLURIPOTENT STEM CELLS EXPRESSING ZNF281

Номер: WO2010107192A3
Автор: KANG, Kyung Sun, ROH, Kyoung Hwan
Принадлежит:

The present invention relates to an isolating method for umbilical cord blood-derived pluripotent stem cells which is characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from culture, the umbilical cord blood-derived pluripotent stem cells isolated thereby, and a cell therapeutic agent containing the umbilical cord blood-derived pluripotent stem cells or differentiated cells therefrom. In addition, the present invention relates to a novel culture media for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture media, and a method for increasing stemness of stem cells which is characterized by sphere culture or three-dimensional culture of stem cells.

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Номер записи: 23
30-11-2017 дата публикации

INDUCED NEURAL STEM CELL PREPARATION METHOD USING NON-NEURONAL CELLS

Номер: WO2017204583A1
Автор: KANG, Kyung Sun, CHOI, Soon Won, SHIN, Ji Hee, LEE, Seung Hee
Принадлежит:

The present invention relates to a composition for inducing transformation of non-neuronal cells into induced neural stem cells, a kit, for inducing transformation of non-neuronal cells into induced neural stem cells, comprising the composition, a method for preparing induced neural stem cells transformed from non-neuronal cells by means of the composition or the kit, and induced neural stem cells prepared by means of the method. By means of the method for transforming non-neuronal cells into induced neural stem cells, as provided in the present invention, normal non-neuronal cells can be transformed into induced neural stem cells without transformation of genes. Therefore, the present invention can widely be utilized for various neurological disorder treatment methods using autologous neural stem cells.

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Номер записи: 24
08-06-2016 дата публикации

Method for Robust Expansion of Umbilical Cord Blood derived-Pluripotent Stem Cell Expressing ZNF281

Номер: KR0101627907B1
Автор: 강경선, 노경환
Принадлежит: 서울대학교산학협력단

... 본 발명은 제대혈로부터 분리된 단핵세포를 피브로넥틴이 포함된 배양 용기내에서 배양한 후 배양물로부터 줄기세포를 회수하는 것을 특징으로 하는 줄기세포의 분리방법, 본 발명에 의해 분리된 제대혈 유래 줄기세포, 상기 줄기세포 또는 이로부터 분화된 세포를 포함하는 세포치료제에 관한 것이다. 또한, 본 발명은 신규한 줄기세포 배양용 배지, 이 배지에서 줄기세포를 배양하여 증식시키는 것을 특징으로 하는 줄기세포의 배양방법 및 줄기세포를 구 배양(sphere culture) 또는 삼차원 배양하는 것을 특징으로 하는 줄기세포의 줄기성(stemness) 증가방법에 관한 것이다.

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Номер записи: 25
01-03-2012 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURED PRODUCT THEREOF

Номер: KR2012026712A2
Автор: KANG, Kyung Sun, KIM, Hyung Sik
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing the stem cells which are obtained by adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, or cultured product thereof, and more specifically, to a method for suppressing the immune diseases or inflammatory diseases of a subject, comprising the step of administering the pharmaceutical composition, the stem cell or a cultured product thereof to a subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or a cultured product thereof, a method for preparing PGE2 or TGF-β1, comprising the step of adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, a graft comprising stem cells which express NOD2 and an NOD2 agonist, a preparation method of the graft, a composite comprising stem cells which express NOD2 and an NOD2 agonist, and a cultured ...

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Номер записи: 26
14-11-2019 дата публикации

METHOD FOR GENERATING INDUCED NEURAL STEM CELLS DIRECTLY REPROGRAMMED FROM NON-NEURAL CELLS BY USING SOX2 AND C-MYC

Номер: WO2019216667A1
Автор: KANG, Kyung-Sun, SEO, Kwang Won, KWON, Daekee, JEE, Min-Jun, HAN, Mi-Jung, AHN, Hee-Jin
Принадлежит:

The present invention relates to a method for generating neural stem cells induced from non-neural cells through direct reprogramming and a use thereof. Because the method for generating induced neural stem cells according to the present invention allows the generation of induced neural stem cells from non-neural cells even when only the two inducing factors Sox2 and c-Myc are used, the method can generate induced neural stem cells more effectively than conventional generation methods using four or five inducing factors. The induced neural stem cells generated by the method exhibit excellent differentiation potency and proliferation activity and thus can be applied to therapeutic purposes in future.

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Номер записи: 27
25-08-2011 дата публикации

CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY

Номер: WO2011102680A3
Автор: KANG, Kyung Sun, YU, Kyung Rok
Принадлежит:

The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient. According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesion culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.

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Номер записи: 28
15-03-2012 дата публикации

EQUINE AMNIOTIC FLUID DERIVED MULTIPOTENT STEM CELLS AND A PRODUCTION METHOD THEREFOR

Номер: KR2012033352A2
Автор: KANG, Kyung Sun, SEO, Min Soo, PARK, Sang Bum
Принадлежит:

The present invention relates to equine amniotic fluid derived multipotent stem cells (eAF-MSCs) and to a production method therefor, and more specifically relates to equine amniotic fluid derived multipotent stem cells which exhibit all negative immunological characteristics with respect to CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P and CD200, and exhibit all positive immunological characteristics with respect to CD44, CD90 and CD105, and have the ability to differentiate into ectodermally, mesodermally or endodermally derived cells. According to the present invention, since it has been confirmed that equine amniotic fluid can be used as a source of supply of equine adult multipotent stem cells and since the produced equine amniotic fluid derived multipotent stem cells exhibit outstanding growth abilities and differentiation abilities, it follows that stem cells can be used as active ingredients of equine cell drugs which are required in volume, and, in particular, the stem ...

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Номер записи: 29
06-10-2011 дата публикации

METHOD FOR INHIBITING THE SENESCENCE OF ADULT STEM CELLS BY INHIBITING MIRNA EXPRESSION

Номер: WO2011122889A2
Автор: KANG, Kyung Sun
Принадлежит:

The present invention relates to a method for inhibiting the senescence of adult stem cells, and more particularly, to a method for inhibiting the senescence of adult stem cells, in which the expression of any one selected from a group consisting of miRNA-23a, miRNA-26a, and miRNA-30a, which are expressed in adult stem cells, is inhibited by a specific inhibitor, to thereby increase the expression of high mobility group A2(HMGA2) and decrease the expression of p16 or p21, thus inhibiting the senescence of adult stem cells. The method for inhibiting the senescence of adult stem cells according to the present invention solves the problem of cell senescence being accelerated as subculturing is performed during adult stem cell culturing, causing a rapid decrease in cell division. The method of the present invention can maintain adult stem cells that preserve differentiation potency and cell regenerative capacity over a prolonged period of time, and thus can ensure an increased number of cells ...

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Номер записи: 30
09-08-2017 дата публикации

비만세포 과립을 처리한 줄기세포 또는 그 배양물을 포함하는 면역질환 또는 염증질환의 예방 또는 치료용 약학조성물

Номер: KR0101766341B1
Автор: 김형식, 이병철, 강경선
Принадлежит: 주식회사 강스템바이오텍

... 본 발명은 줄기세포에 비만세포 과립을 첨가하여 배양한 줄기세포 또는 그 배양물을 포함하는 면역질환 및 염증질환의 예방 또는 치료용 약학조성물에 관한 것이다.

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Номер записи: 31
15-03-2012 дата публикации

EQUINE AMNIOTIC FLUID DERIVED MULTIPOTENT STEM CELLS AND A PRODUCTION METHOD THEREFOR

Номер: WO2012033352A3
Автор: KANG, Kyung Sun, SEO, Min Soo, PARK, Sang Bum
Принадлежит:

The present invention relates to equine amniotic fluid derived multipotent stem cells (eAF-MSCs) and to a production method therefor, and more specifically relates to equine amniotic fluid derived multipotent stem cells which exhibit all negative immunological characteristics with respect to CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P and CD200, and exhibit all positive immunological characteristics with respect to CD44, CD90 and CD105, and have the ability to differentiate into ectodermally, mesodermally or endodermally derived cells. According to the present invention, since it has been confirmed that equine amniotic fluid can be used as a source of supply of equine adult multipotent stem cells and since the produced equine amniotic fluid derived multipotent stem cells exhibit outstanding growth abilities and differentiation abilities, it follows that stem cells can be used as active ingredients of equine cell drugs which are required in volume, and, in particular, the stem ...

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Номер записи: 32
21-07-2011 дата публикации

PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER, CONTAINING AN EXTRACELLULAR MATRIX OF MESENCHYMAL STEM CELLS DERIVED FROM UMBILICAL CORD BLOOD AS AN ACTIVE INGREDIENT

Номер: WO2011087299A3
Автор: KANG, Kyung sun
Принадлежит:

The present invention relates to a pharmaceutical composition for the treatment of cancer, containing an extracellular matrix (ECM) of mesenchymal stem cells derived from umbilical cord blood as an active ingredient, and more specifically, to a pharmaceutical composition for the treatment of cancer, containing an ECM as an active ingredient, obtained by culturing mesenchymal stem cells derived from umbilical cord blood and removing only cells. The ECM of mesenchymal stem cells derived from umbilical cord blood may suppress the proliferation of various cancers, such as breast cancer, melanoma, pancreatic cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, etc. and minimize problems in manufacturing pharmaceutical or individual deviations when stem cells are used. In addition, side effects, which may occur from the in vivo injection of cells, may be fundamentally prevented.

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Номер записи: 33
13-05-2016 дата публикации

NATURAL COMPOSITION HAVING BRAIN CELL PROTECTIVE FUNCTION AND HEALTH DRINK USING SAME

Номер: KR1020160052824A
Автор: KIM, SUNG CHUL, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a health drink including a ramie leaf fermented product having a brain cell protective function, turmeric, Gastrodia elata, Asian milkwort, Salvia miltiorrhiza, Chinese quince, Paeonia japonica, Glycyrrhiza uralensis Fischer, Atractylis chinensis, refined tuber, Ixeris dentata, oats, and Gombo-Baechu, as active ingredients. More specifically, the present invention relates to a health drink using a ramie leaf fermented product having an antioxidant effect inhibiting oxidative stress induced by glutamate in a HT22 cell line which is mouse hippocampal cells, and an anti-inflammatory effect inhibiting inflammatory mediators activated and secreted to LPS in a BV2 cell line which is mouse microglial cells. The health drink also uses turmeric, Gastrodia elata, Asian milkwort, Salvia miltiorrhiza, Chinese quince, Paeonia japonica, Glycyrrhiza uralensis Fischer, Atractylis chinensis, refined tuber, Ixeris dentata, oats, and Gombo-Baechu. In addition, the present ...

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Номер записи: 34
23-09-2010 дата публикации

ISOLATING METHOD FOR UMBILICAL CORD BLOOD-DERIVED PLURIPOTENT STEM CELLS EXPRESSING ZNF281

Номер: KR2010107192A2
Автор: KANG, Kyung Sun, ROH, Kyoung Hwan
Принадлежит:

The present invention relates to an isolating method for umbilical cord blood-derived pluripotent stem cells which is characterized by culturing monocytes isolated from umbilical cord blood in a culture vessel containing fibronectin and then harvesting stem cells from culture, the umbilical cord blood-derived pluripotent stem cells isolated thereby, and a cell therapeutic agent containing the umbilical cord blood-derived pluripotent stem cells or differentiated cells therefrom. In addition, the present invention relates to a novel culture media for stem cells, a culture method for stem cells which is characterized by culturing and proliferating stem cells in the culture media, and a method for increasing stemness of stem cells which is characterized by sphere culture or three-dimensional culture of stem cells.

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Номер записи: 35
01-03-2012 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURED PRODUCT THEREOF

Номер: WO2012026712A3
Автор: KANG, Kyung Sun, KIM, Hyung Sik
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing the stem cells which are obtained by adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, or cultured product thereof, and more specifically, to a method for suppressing the immune diseases or inflammatory diseases of a subject, comprising the step of administering the pharmaceutical composition, the stem cell or a cultured product thereof to a subject, a method for preparing an immunosuppressive drug or an anti-inflammatory drug using the stem cells or a cultured product thereof, a method for preparing PGE2 or TGF-β1, comprising the step of adding an NOD2 agonist to stem cells which express NOD2 and culturing the stem cells, a graft comprising stem cells which express NOD2 and an NOD2 agonist, a preparation method of the graft, a composite comprising stem cells which express NOD2 and an NOD2 agonist, and a cultured ...

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Номер записи: 36
28-04-2022 дата публикации

METHOD FOR CONSTRUCTION OF ATOPIC DERMATITIS MODEL BY USING PLURIPOTENT STEM CELL-DERIVED SKIN ORGANOID

Номер: WO2022086218A1
Автор: KANG, Kyung-Sun, JUNG, Song-Yi
Принадлежит:

The present invention relates to a method for construction of an atopic dermatitis skin organoid from a human pluripotent stem cell. It was observed that ALI-skin organoids of the present invention formed skin cells, adjuncts, neural cells, adipocytes, and the like in similar structures to those in the real skin and exhibited greatly improved follicle growth, compared to skin organoids constructed by conventional culturing methods. In addition, as a result of treatment with Staphylococcus aureus to construct an atopic dermatitis model, a good simulation was made of the characteristics of atopic dermatitis, such as damaged skin barriers, increased epithelium-derived cytokines and downregulated epidermal stem cell expression, causing Staphylococcus aureus colonies, etc. Thus, the skin organoid of the present invention is expected to find advantageous applications as a real skin model and an atopic dermatitis model.

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Номер записи: 37
04-10-2016 дата публикации

퇴행성 신경계질환에 유효한 오공을 포함하는 복합약침의 제조방법 및 상기 방법으로 제조된 복합약침

Номер: KR0101661966B1
Автор: 김성철, 강경선
Принадлежит: 원광대학교산학협력단, 주식회사 강스템바이오텍

... 본 발명은 퇴행성 신경질환에 유효한 오공을 포함하는 복합약침의 제조방법 및 상기 방법으로 제조된 복합약침에 관한 것이다. 구체적으로는 왕지네 겔을 제조하는 단계; 왕지네 겔 혼합액을 제조, 추출 및 농축하는 단계; 왕지네 겔 혼합액을 1차 파쇄 및 균질화하는 단계; 왕지네 겔 혼합액을 2차 파쇄하는 단계; 왕지네 겔 혼합액을 여과하는 단계; 및 왕지네 겔 혼합액에 추가 소재를 혼합하는 단계;를 포함하는 퇴행성 신경질환에 유효한 오공을 포함하는 복합약침의 제조방법 및 상기 방법으로 제조된 복합약침에 관한 것이다. 본 발명은 상기 왕지네 겔 혼합액에 추가 소재를 혼합하는 단계에서 추가 소재는 봉독, 태반 또는 이들의 혼합물인 것을 특징으로 하고 있다. 본 발명의 방법으로 제조된 퇴행성 신경질환에 유효한 오공을 포함하는 복합약침은 왕지네 함유 성분의 추출 효율이 높으며, 특히 알라닌 함유율이 높음으로써 독성 및 부작용이 낮은 효과를 보유하고 있다.

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Номер записи: 38
21-07-2017 дата публикации

STEM CELL-DERIVED EXOSOMES CONTAINING HIGH AMOUNT OF GROWTH FACTORS

Номер: KR1020170085010A
Автор: KANG, KYUNG SUN, SEO, KWANG WON, KIM, YU LEE, KIM, YOON JIN
Принадлежит:

The present invention relates to exosomes containing a high amount of growth factors, which are obtained from stem cells cultured in a medium containing epidermal growth factor (EGF) and/or fibroblast growth factor (FGF). The exosomes isolated from a stem cell culture liquid permeate the skin dermis layer with nanosize, thereby increasing regeneration effects, and contains much various growth factors, thereby having skin regeneration and anti-aging effects, collagen synthesis increase, hair growth, tightened follicle restoration and wound healing effects through proliferation and activation of fibroblast, skin organization cells. COPYRIGHT KIPO 2017 (A1,A2) Relative expression (1 = UCB - MSC - Exosome) (B1,B2) UCB-MSC exosome (C1,C2) AD-MSC exosome (D1,D2) BM-MSC exosome ...

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Номер записи: 39
31-03-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, COMPRISING INTERFERON-GAMMA OR INTERLEUKIN-1 BETA TREATED STEM CELL OR CULTURE THEREOF

Номер: WO2016048107A1
Автор: KIM, Yu Lee, LEE, Seung Hee, SEO, Kwang Won, KANG, Kyung Sun
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases and inflammatory diseases, comprising a stem cell or a culture thereof, the stem cell being cultured by adding, to a stem cell, inflammatory cytokines of interferon-gamma and interleukin-1 beta.

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Номер записи: 40
05-04-2016 дата публикации

INTERFERON-GAMMA OR INTERLEUKIN-1 BETA-TREATED STEM CELL OR PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING IMMUNOLOGICAL OR INFLAMMATORY DISEASE, CONTAINING CULTURE PRODUCT THEREOF

Номер: KR1020160037113A
Автор: KIM, YU LEE, LEE, SEUNG HEE, SEO, KWANG WON, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a stem cell which is cultured by treating the stem cells with inflammatory cytokine including interferon gamma (IFNγ) and interleukin-1 beta (IL-1β). The present invention further relates to a pharmaceutical composition for preventing or treating immunological or inflammatory disease, containing the cultured product thereof. COPYRIGHT KIPO 2016 ...

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Номер записи: 41
05-04-2016 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, COMPRISING STEM CELLS TREATED WITH MAST CELL GRANULES OR CULTURE THEREOF

Номер: KR1020160037099A
Автор: KIM, HYUNG SIK, LEE, BYUNG CHUL, SEO, KWANG WON, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases and inflammatory diseases, comprising stem cells cultured by adding mast cell granules, or a culture thereof. The pharmaceutical composition can replace conventional immunosuppressants and anti-inflammatory agents. COPYRIGHT KIPO 2016 ...

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Номер записи: 42
20-04-2016 дата публикации

METHOD FOR PRODUCING MIXED INJECTION LIQUID COMPRISING SCOLOPENDRA SUBSPINIPES EFFECTIVE FOR NEURODEGENERATIVE DISEASES, AND MIXED INJECTION LIQUID OBTAINED THEREBY

Номер: KR1020160042484A
Автор: KIM, SUNG CHUL, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a method for producing a mixed injection liquid comprising Scolopendra subspinipes effective for neurodegenerative diseases and a mixed injection liquid obtained thereby. Particularly, the present invention relates to a method for producing a mixed injection liquid comprising Scolopendra subspinipes effective for neurodegenerative disease, which comprises the steps of: forming gel of Scolopendra subspinipes; preparing, extracting and concentrating a gel mixture of Scolopendra subspinipes; crushing and homogenizing the gel mixture of Scolopendra subspinipes; further crushing the gel mixture of Scolopendra subspinipes; filtering the gel mixture of Scolopendra subspinipes; and adding and mixing additional materials to the gel mixture of Scolopendra subspinipes, as well as a mixed injection liquid obtained by the method. According to the present invention, in the step of adding and mixing additional materials to the gel mixture of Scolopendra subspinipes, the ...

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Номер записи: 43
25-08-2011 дата публикации

CD49F PROMOTING PROLIFERATION, MULTIPOTENCY AND REPROGRAMMING OF ADULT STEM CELLS THROUGH PI3K/AKT/GSK3 PATHWAY

Номер: WO2011102680A2
Автор: KANG, Kyung Sun, YU, Kyung Rok
Принадлежит:

The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient. According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesion culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.

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Номер записи: 44
31-05-2019 дата публикации

ANTI-INFLAMMATORY COMPOSITION COMPRISING GRAPHENE NANO-STRUCTURE

Номер: WO2019103541A1
Автор: KANG, Kyung-Sun, LEE, Byung-Chul, LEE, Jin Young, PARK, Jong Bo
Принадлежит:

The present invention relates to an anti-inflammatory composition comprising a graphene nano-structure as an active ingredient thereof. Specifically, the present invention relates to: a pharmaceutical composition for prevention or treatment of an inflammatory disease, comprising the composition; a cosmetic composition or feed composition for prevention or amelioration of an inflammatory disease; and a method for treating an inflammatory disease, comprising a step of administering the composition to a subject in need thereof.

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Номер записи: 45
11-05-2017 дата публикации

COMPOSITION FOR INDUCING DIFFERENTIATION OF RETINAL PIGMENT EPITHELIUM

Номер: KR1020170049775A
Автор: KANG, KYUNG SUN, CHOI, SOON WON, LEE, SEUNG HEE
Принадлежит:

The present invention relates to a composition for inducing differentiation of retinal pigment epithelium containing miR-410 inhibitor. The present invention further relates to a kit for inducing differentiation of retinal pigment epithelium containing the composition, a method for differentiating mesenchymal stem cells into retinal pigment epithelium using the composition, and a pharmaceutical composition for treating retinal disease containing the composition-treated mesenchymal stem cells. The composition containing miR-410 inhibitor allows the mesenchymal stem cells to differentiate into retinal pigment epithelium without a need of specific condition, and thus can be widely applied to treatment of various retinal diseases caused by damage on retinal pigment epithelium. COPYRIGHT KIPO 2017 ...

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Номер записи: 46
23-03-2017 дата публикации

COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES COMPRISING STEM CELLS OVEREXPRESSING SOD3 AS ACTIVE INGREDIENT

Номер: KR1020170032872A
Автор: KANG, KYUNG SUN, KIM, TAE YOON
Принадлежит:

Provided is a pharmaceutical composition for preventing or treating inflammatory diseases comprising stem cells overexpressing SOD3 as active ingredients. An inventor of the present invention confirmed that mesenchymal stem cells (MSC) overexpressing SOD3 have stronger antioxidant activity and immune regulatory function than normal MSC. Accordingly, MSC overexpressing SOD3 can be an effective medicine with respect to inflammatory diseases, auto-immune diseases, rejection of transplanted organs, etc. COPYRIGHT KIPO 2017 ...

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Номер записи: 47
11-01-2018 дата публикации

COMPLEX COMPRISING CARTILAGE CELL-FREE LYSATE AND STEM CELL FOR PROMOTING CARTILAGE DIFFERENTIATION AND USE THEREOF

Номер: WO2018008941A1
Автор: KANG, Kyung Sun, SEO, Kwang Won, YOON, Kyung Ae, JEON, Hyo Jin, SIM, Yun Beom
Принадлежит:

The present invention relates to a complex comprising stem cells or a culture thereof and a cartilage cell-free lysate for promoting cartilage differentiation, a method for fabricating cartilage by using the complex, cartilage fabricated by the method, a pharmaceutical composition comprising the complex for preventing or treating arthropathy, a method for preventing or treating arthropathy by using the composition, a composition comprising the prepared cartilage cells for inducing cartilage cell differentiation, and a method for fabricating cartilage by using the prepared cartilage cells. The complex, provided by the present invention, comprising stem cells or a culture thereof and a cartilage cell-free lysate for promoting cartilage differentiation is not only differentiated into cartilage cells in vivo without side effects, but also promotes the differentiation of intrinsic stem cells, which exist in vivo, into cartilage cells thanks to the paracrine effect arising in differentiated cartilage ...

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Номер записи: 48
07-11-2016 дата публикации

뇌신경세포 보호 기능이 있는 천연물 조성물 및 그를 이용한 건강 음료

Номер: KR0101673204B1
Автор: 김성철, 강경선
Принадлежит: 원광대학교산학협력단, 주식회사 강스템바이오텍

... 본 발명은 뇌신경세포 보호 기능이 있는 모시잎 발효물과 강황, 천마, 원지, 단삼, 모과, 백작약, 감초, 창출, 정제부자, 씀바귀, 귀리 및 곰보 배추를 유효성분으로 함유하는 건강음료에 관한 것으로, 더욱 상세하게는 마우스 해마 세포인 HT22 세포주에서 글루타메이트 (glutamate)에 의해 유도된 산화적 스트레스를 억제하는 항산화 효능과, 마우스 미세아교세포인 BV2 세포주에서 LPS로 활성화되어 분비되는 염증매개물질을 억제하는 항염증 효능이 있는 모시잎 발효물과 강황, 천마, 원지, 단삼, 모과, 백작약, 감초, 창출, 정제부자, 씀바귀, 귀리 및 곰보 배추를 이용한 건강음료에 관한 것이다. 또한, 본 발명은 모시잎 발효물을 포함한 천연물 조성물에 커피를 추가하여 기호도를 상승시키는 건강 음료에 관한 것이다.

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Номер записи: 49
08-08-2017 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING STEM CELLS TREATED WITH NOD2 AGONIST OR CULTURE THEREOF FOR PREVENTING OR TREATING IMMUNE DISEASES AND INFLAMMATORY DISEASES

Номер: KR1020170091064A
Автор: KANG, KYUNG SUN, KIM, HYUNG SIK
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, comprising stem cells which are obtained by culturing NOD2-expressing stem cells with an NOD2 agonist, or a culture thereof. Specifically, the present invention relates to a method for suppressing immune responses or inflammatory responses of a subject, comprising a step of administering the pharmaceutical composition, the stem cells, or a culture thereof to a subject; a method for preparing an immunosuppressive drug or an anti-inflammatory drug by using the stem cells or a culture thereof; a method for preparing PGE2 or TGF-β1, comprising a step of culturing NOD2-expressing stem cells with an NOD2 agonist; a graft comprising NOD2-expressing stem cells and an NOD2 agonist; a preparation method of the graft; a composite comprising NOD2-expressing stem cells and an NOD2 agonist; and a culture obtained by adding an NOD2 agonist to NOD2-expressing stem cells. The ...

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Номер записи: 50
13-06-2013 дата публикации

CANINE AMNIOTIC MEMBRANE-DERIVED MULTIPOTENT STEM CELLS

Номер: WO2013085303A1
Автор: KANG, Kyung Sun, SEO, Min Soo, PARK, Sang Bum
Принадлежит:

The present invention relates to canine amniotic membrane-derived multipotent stem cells (cAM-MSCs) and a method for producing same. More particularly, the present invention relates to canine amniotic membrane-derived multipotent stem cells showing negative immunological properties on human markers CD3, CD11c, CD28, CD34, CD38, CD41a, CD45, and CD62L and positive immunological properties on human markers CD90 and CD105, and having the ability to be subcultured up to passage 20 or more in an undifferentiated state and the ability to be differentiated into fat, bones, nerves, cartilage, etc.

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Номер записи: 51
06-08-2020 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF LYSOSOMAL STORAGE DISORDERS

Номер: WO2020159159A2
Автор: KANG, Kyung-Sun, HONG, Byung Hee, KANG, Insung, YOO, Je Min, KIM, Donghoon
Принадлежит:

The present invention relates to a pharmaceutical composition for the prevention or treatment of lysosomal storage disorders and, more specifically, to a pharmaceutical composition comprising graphene quantum dots, thereby being capable of exhibiting excellent efficacy against various lysosomal storage disorders including Niemann-Pick disease.

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Номер записи: 52
22-11-2016 дата публикации

ｍｉＲＮＡ-141의 억제를 이용한 세포의 노화 억제 방법

Номер: KR0101678249B1
Автор: 강경선, 유경록
Принадлежит: 서울대학교산학협력단

... 본 발명은 세포의 노화 억제 방법에 관한 것으로서, 더욱 상세하게는 miRNA-141을 억제함으로써, 세포의 ZMPSTE24 발현을 증가시켜 세포의 노화를 억제하는 방법 및 세포의 증식 방법에 관한 것이다. 본 발명에 따른 세포의 노화 억제 방법 및 증식 방법은 세포 배양시 계대배양을 시행할수록 세포의 노화가 빠른 속도로 진행되어 세포 분열이 급격히 감소하는 문제점을 해결할 수 있으며, 그에 따라 분화능과 세포 재생 능력을 그대로 유지한 성체줄기세포를 오래 유지할 수 있어 세포 치료제 또는 연구용으로 사용할 수 있는 세포를 더욱 많이 확보할 수 있다. 또한, 인간과 동물의 노화 과정에서 생체내 줄기세포수가 감소하는 원인을 밝혀냄으로써, 노화 현상을 보다 구체적으로 규명할 수 있을 것으로 기대된다.

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Номер записи: 53
12-10-2018 дата публикации

말과동물 양막-유래 중간엽 줄기세포

Номер: KR0101906156B1
Автор: 강경선, 서민수, 박상범
Принадлежит: 주식회사 강스템바이오텍

... 본 발명은 말과동물 양막-유래 중간엽 줄기세포(equine amniotic membrane-derived mesenchymal stem cells; eAM-MSCs) 및 그의 제조방법에 관한 것이다. 보다 상세하게는, 사람 마커인 CD19, CD20, CD28, CD31, CD34, CD38, CD41a, CD62L, CD62P 및 CD200에 대하여 모두 음성의 면역학적 특성을 나타내고, 사람 마커인 CD44, CD90 및 CD105에 대하여 모두 양성의 면역학적 특성을 나타내며, 미분화 상태로 14계대 이상 배양되는 능력 및 외배엽, 중배엽 또는 내배엽 유래 세포로 분화하는 능력을 가지는, 말과동물 양막-유래 중간엽 줄기세포에 관한 것이다.

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Номер записи: 54
22-03-2016 дата публикации

REGULATION METHOD OF PROLIFERATION, MAINTENANCE AND AGING OF STROMAL CELLS BY CONTROLLING HMGA2 PROTEIN EXPRESSION

Номер: KR1020160031210A
Автор: KANG, KYUNG SUN, YU, KYUNG ROK
Принадлежит:

The present invention relates to a regulation method of the proliferation, the maintenance, and the aging of stromal cells by controlling the HMGA2 protein expression. More specifically, the present invention relates to a regulation method of the proliferation, the maintenance, and the aging of stromal cells by controlling the HMGA2 protein expression, for proliferating the stromal cells, maintaining the differentiation ability, and inhibiting the aging, by controlling the HMGA2 protein expression. COPYRIGHT KIPO 2016 ...

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Номер записи: 55
09-07-2018 дата публикации

METHOD FOR DUAL-DIFFERENTIATING HEPATOCYTES AND BILE DUCT CELLS OF STEM CELLS AND USES THEREOF

Номер: KR1020180077840A
Автор: WOO, HEUNG MYONG, PARK, KYUNG MEE, LEE, YUN SUK, YU, LI NA, KANG, KYUNG SUN
Принадлежит:

The present invention relates to a method for dual-differentiating hepatocytes and bile duct cells of stem cells and to uses thereof, and when reprogrammed stem cells are transplanted into a biodegradable biocompatible scaffold of the present invention, the survival rate, functions and differentiation rate of the transplanted cells into specific cells are improved, and a reconstructed microstructure maximizes in vivo efficiency and can be effectively used as a bio organ. COPYRIGHT KIPO 2018 ...

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Номер записи: 56