06-03-2014 дата публикации
Номер: WO2014035179A1
Принадлежит:
The present invention relates to a mitochondrial targeting peptide, to a fusion protein in which the peptide is bound to the carboxyl terminal of a protein transduction domain, to a fusion protein in which the peptide is bound to the carboxyl terminal of a protein transduction domain and an antioxidant is bound to the carboxyl terminal of the peptide, to an antioxidant composition and a composition for preventing or treating Parkinson's disease comprising the fusion protein in which the antioxidant is bound, to a recombinant polynucleotide in which a polynucleotide coding a protein transduction domain, a polynucleotide coding the peptide, and a polynucleotide coding an antioxidant protein are sequentially bound, to an expression vector comprising the polynucleotide, and to a transformed host cell comprising the expression vector. The mitochondrial targeting peptide according to the present invention not only targets mitochondria with high efficiency if the peptide exists alone, but also ...
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