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Применить Всего найдено 62. Отображено 62.
10-07-2017 дата публикации

SELECTIVE SYNTHESIS METHOD OF CATIONIC LIPID

Номер: KR1020170079370A
Автор: CHOI, SUNG WON, NAM, HYE YEONG, SEO, MIN HYO
Принадлежит:

The present invention relates to a selective synthesis method of cationic lipid and, more specifically, to a method capable of selectively synthesizing cationic lipid by controlling the introduction ratio of a fatty acid group to an oligoalkyleneamine through changing reaction conditions. COPYRIGHT KIPO 2017 ...

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Номер записи: 1
27-05-2010 дата публикации

POLYMER MICELLE COMPOSITION FOR TREATMENT OF RESISTANT CANCER CELLS

Номер: KR2010059001A2
Автор: KANG, Hye-Won, SEO, Min Hyo, KIM, Bong Oh
Принадлежит:

Disclosed are a polymer micelle composition for treatment of resistant cancer cells that contains an amphiphilic double block copolymer and taxane and a p-glycoprotein inhibitor of cyclosporin as its active ingredients, and a method of preparing the same. Said polymer micelle composition for treatment of cancer resistant cells is accumulated in cancer tissues at high concentrations, and has the advantages that it exhibits superior anti-cancer effects for the cancer cells that have exhibited resistance due to over-expression of p-glycoprotein by the taxane anti-cancer agent in said cancer tissues, and does not cause hypersensitive reactions due to the use of a solubilizer.

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Номер записи: 2
14-02-2018 дата публикации

음이온성 약물 함유 약제학적 조성물 및 그 제조방법

Номер: KR0101828877B1
Автор: 남혜영, 김봉오, 서민효, 손지연, 최지혜, 김상훈
Принадлежит: 주식회사 삼양바이오팜

... 유효성분으로서 음이온성 약물; 양이온성 화합물; 양친성 블록 공중합체 및 폴리락트산염을 포함하며, 상기 음이온성 약물은 상기 양이온성 지질과 복합체를 형성하고, 상기 복합체가 양친성 블록 공중합체 및 폴리락트산염이 형성하는 미셀 구조 내부에 봉입되는 것을 특징으로 하는 음이온성 약물 전달용 약제학적 조성물과 그 제조방법이 개시된다.

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Номер записи: 3
17-10-2019 дата публикации

METHOD FOR PREPARING ORALLY ADMINISTERED SOLID FORMULATION COMPRISING LENALIDOMIDE

Номер: WO2019199135A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

The present invention relates to a method for preparing a lenalidomide tablet for oral administration comprising: a first step for mixing a pharmaceutically acceptable additive; a second step for mixing the mixture from the first step and lenalidomide; a third step for mixing the mixture from the second step and a lubricant; and a fourth step for directly tableting the mixture from the third step.

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Номер записи: 4
09-05-2019 дата публикации

ORAL SOLID DOSAGE FORM COMPOSITION HAVING IMPROVED DISINTEGRATION AND PREPARATION METHOD THEREFOR

Номер: WO2019088669A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Jae Young, SEO, Min Hyo, LEE, Sa Won
Принадлежит:

Disclosed are an oral solid dosage form composition comprising an active ingredient and a solubilizing carrier wherein a foaming ingredient is used to improve disintegration, dispersion or dissolution, and a preparation method therefor.

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Номер записи: 5
27-06-2013 дата публикации

COMPOSITION COMPRISING BIODEGRADABLE POLYMER FINE PARTICLES HAVING IMPROVED DISPERSIBILITY AND METHOD FOR PREPARING SAME

Номер: WO2013094955A1
Автор: LEE, Sang Jun, YOON, Hye Jeong, SEO, Min Hyo
Принадлежит:

The present invention relates to a composition comprising biodegradable polymer fine particles having improved dispersibility and a method for preparing same, and more particularly, a solid composition comprising a biodegradable polymer and a method for preparing same, wherein, the solid composition comprising a biodegradable polymer includes biodegradable polymer fine particles and a dispersing agent in a sustained released dosage form comprising a salt of poly lactic acid or a derivative thereof, to thus be suspended by only using distilled water or other water for injection, reduce suspension time, and increase the usability for a suspension.

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Номер записи: 6
08-02-2017 дата публикации

항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법

Номер: KR0101703980B1
Автор: 조중웅, 김경해, 서민효, 이사원
Принадлежит: 주식회사 삼양바이오팜

... 페메트렉시드와 같이 산화에 의한 분해가 쉽게 일어나는 약물을 포함하는 조성물의 제조에 있어서 항산화제를 사용하지 않고 제조공정상에서 산소를 제거하여 안정성을 높인 조성물 및 그 제조방법이 개시된다. 상기 제조방법은 밀폐된 챔버 내에서 동결 및 탈기하여 제조의 용이성을 높인 제조방법이며, 산화에 불안정한 약물의 안정성을 획기적으로 높인 조성물을 제공할 수 있다.

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Номер записи: 7
08-02-2017 дата публикации

PHARMACEUTICAL COMPOSITION HAVING IMPROVED STORAGE STABILITY AND PRODUCTION METHOD THEREOF

Номер: KR1020170015198A
Автор: KIM, BONG OH, MIN, BUM CHAN, KIM, JI YEONG, KIM, HYE RIM, SEO, MIN HYO, LEE, SA WON, YI, YIL WOONG, CHO, JOONG WOONG, CHOI, IN JA
Принадлежит:

Provided are a pharmaceutical composition comprising a content of a specific soft substance below standard and having improved storage stability, and a production method thereof. COPYRIGHT KIPO 2017 (AA) Comparative example 1-0d (BB) Comparative example 1-3w (CC) Example 1-0d (DD) Example 1-3w (EE) Example 2-0d (FF) Example 2-3w ...

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Номер записи: 8
02-04-2020 дата публикации

COMPOSITION COMPRISING DOXORUBICIN AS ACTIVE INGREDIENT, AND PREPARATION METHOD THEREFOR

Номер: WO2020067730A1
Автор: KIM, Gyeong Hae, LEE, Sa Won, KIM, Goo Young, MOON, Gyu Young, YUN, Min Hyuk, JEONG, Seung Wei, JIN, Geun Woo, SEO, Min Hyo, JEONG, Kwang Il
Принадлежит:

An anticancer nano-drug composition for inducing immunogenic cell death, and a use thereof are disclosed.

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Номер записи: 9
20-06-2013 дата публикации

COMPOSITION OF AN AQUEOUS SOLUTION OF POLYMERIC NANOPARTICLES AND METHOD FOR PREPARING SAME

Номер: WO2013089394A3
Автор: LEE, Sa-Won, CHO, Joong-Woong, KIM, Gyeong-Hae, SEO, Min-Hyo
Принадлежит:

Disclosed are a pharmaceutical composition including a polymeric drug carrier having enhanced stability in an aqueous solution and a method for stabilizing same. More particularly, a pharmaceutical composition in the form of an aqueous solution and a method for stabilizing same are disclosed, wherein the pharmaceutical composition maintains preservation stability for at least six months, and preferably at least 12 months in the case of refrigeration, and includes a polymeric drug carrier containing an amphiphilic block copolymer, which is composed of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative of which a bivalent or trivalent metal ion binds to a carboxyl group at a terminal thereof.

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Номер записи: 10
25-04-2018 дата публикации

LENALIDOMIDE TABLET COMPOSITION FOR ORAL ADMINISTRATION

Номер: KR1020180042115A
Автор: PARK, SANG YEOB, LIM, HYE JUNG, LEE, SA WON, SEO, MIN HYO
Принадлежит:

The present invention relates to a tablet composition for oral administration containing lenalidomide, and a production method thereof. More specifically, the present invention relates to a composition in a form of tablets, which shows physico-chemical equivalence with lenalidomide preparations produced in a form of hard capsules, and exhibits equivalent pharmacological treatment effects as equivalence is secured in non-clinical studies and bioequivalence studies. In addition, the composition also ensures improved safety, handlability, and convenience in administration. The present invention further relates to a production method thereof. COPYRIGHT KIPO 2018 (AA) Comparative example 1 (BB) Example 1 ...

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Номер записи: 11
17-10-2019 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING LENALIDOMIDE

Номер: WO2019199134A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, SEO, Min Hyo, LEE, Sa Won
Принадлежит:

The present invention relates to a lenalidomide tablet formulation prepared by means of tableting lenalidomide in which D50 of lenalidomide exceeds 2㎛.

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Номер записи: 12
19-10-2017 дата публикации

보관 안정성이 향상된 약학 조성물 및 그의 제조 방법

Номер: KR0101787447B1
Автор: 김봉오, 경규진, 김지영, 김혜림, 민범찬, 윤유정, 서민효, 이일웅
Принадлежит: 주식회사 삼양바이오팜

... 특정 유연물질의 함량을 기준 이하로 포함하는 약학 조성물 및 그의 제조 방법이 제공된다.

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Номер записи: 13
08-02-2017 дата публикации

METHOD FOR PURIFYING AMPHIPHILIC BLOCK COPOLYMER, AMPHIPHILIC BLOCK COPOLYMER OBTAINED THEREFROM, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

Номер: KR1020170014058A
Автор: KIM, BONG OH, KIM, JI YEONG, KIM, HYE RIM, MIN, BUM CHAN, SEO, MIN HYO, LEE, SA WON, YI, YIL WOONG, CHO, JOONG WOONG, CHOI, IN JA
Принадлежит:

The present invention relates to a method for purifying an amphiphilic block copolymer while inhibiting a decrease in the molecular weight by a sublimation process, an amphiphilic block copolymer obtained by the purification method and a pharmaceutical composition comprising the amphiphilic block copolymer. The purification method comprises the process of sublimating an amphiphilic block copolymer comprising a hydrophilic block (A) and a hydrophobic block (B). COPYRIGHT KIPO 2017 (AA) Comparative example 2-0d (BB) Comparative example 2-3w (CC) Comparative example 3-0d (DD) Comparative example 3-0w ...

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Номер записи: 14
01-12-2016 дата публикации

STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING SAME

Номер: WO2016190712A2
Автор: CHO, Joong-Woong, KIM, Gyeong-Hae, SEO, Min-Hyo, LEE, Sa-Won
Принадлежит:

Relating to the preparation of a composition including a drug such as pemetrexed which is easily degraded through oxidation, disclosed are a composition having increased stability by removing oxygen during the process of preparation of and to a method of preparing same. The preparation method is made easier by freezing and degassing in a sealed chamber, and therefore the preparation method can provide a composition having remarkably increased stability of an oxidation-labile drug.

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Номер записи: 15
22-06-2017 дата публикации

METHOD FOR PREPARING POLYMERIC MICELLE CONTAINING ANIONIC DRUG

Номер: WO2017105138A1
Автор: NAM, Hye Yeong, KIM, Sang-Hee, SEO, Min-Hyo, SON, Ji-Yeon
Принадлежит:

The present invention relates to a preparation method comprising the steps of: producing nanoparticles in an aqueous phase using electrostatic bonding between an anionic drug and a cationic compound, and incorporating the nanoparticles into a polymeric micelle consisting of an amphiphilic polymer and any polylactic acid salt, to thereby increase the yield for preparing a composition for delivering an anionic drug by raising the anionic drug inclusion rate of the formulation though the increase of electrostatic bonding and hydrophobic bonding.

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Номер записи: 16
08-02-2017 дата публикации

PHARMACEUTICAL COMPOSITION HAVING IMPROVED STORAGE STABILITY AND PRODUCTION METHOD THEREOF

Номер: KR1020170014059A
Автор: KIM, BONG OH, KYUNG, KYU JIN, KIM, JI YEONG, KIM, HYE RIM, MIN, BUM CHAN, YOON, YOO JEONG, SEO, MIN HYO, YI, YIL WOONG
Принадлежит:

Provided are a pharmaceutical composition comprising a content of a specific soft substance below standard, which can improve storage stability by inhibiting the production of a soft substance, and a production method thereof. COPYRIGHT KIPO 2017 (AA) Example 1-0d (BB) Example 1-3w (CC) Example 2-0d (DD) Example 2-3w (EE) Example 3-0d (FF) Example 3-3w ...

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Номер записи: 17
16-03-2017 дата публикации

RELATED SUBSTANCE AS STANDARD FOR EVALUATION OF PHARMACEUTICAL COMPOSITION CONTAINING POLYMERIC CARRIER

Номер: KR1020170030085A
Автор: KIM, HYE RIM, KIM, JI YEONG, MIN, BUM CHAN, SEO, MIN HYO, CHOI, HO JOON
Принадлежит:

Provided is a method for analyzing a related substance in a pharmaceutical composition containing an amphiphilic block copolymer consisting of a hydrophilic block and a hydrophobic block as a drug carrier. Also, provided are a related substance isolated by the same, and a method for evaluating the pharmaceutical composition using the same. According to the present invention, the related substance in the pharmaceutical composition containing a polymeric carrier and a water insoluble drug is used as standard so impurities generated in completed drugs can be precisely analyzed. COPYRIGHT KIPO 2017 ...

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Номер записи: 18
06-07-2017 дата публикации

METHOD FOR SELECTIVELY SYNTHESIZING CATIONIC LIPIDS

Номер: WO2017116188A2
Автор: CHOI, Sungwon, NAM, Hye Yeong, SEO, Min-Hyo
Принадлежит:

The present invention relates to a method capable of selectively synthesizing cationic lipids by adjusting the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of a reaction condition.

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Номер записи: 19
19-06-2017 дата публикации

보관 안정성이 향상된 약학 조성물 및 그의 제조 방법

Номер: KR0101748191B1
Автор: 김봉오, 민범찬, 김지영, 김혜림, 서민효, 이사원, 이일웅, 조중웅, 최인자
Принадлежит: 주식회사 삼양바이오팜

... 특정 유연물질의 함량을 기준 이하로 포함하는 약학 조성물 및 그의 제조 방법이 제공된다.

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Номер записи: 20
07-07-2011 дата публикации

MACROMOLECULE FOR DELIVERING PROTEIN, POLYPEPTIDE OR PEPTIDE DRUGS AND A PRODUCTION METHOD FOR THE SAME, AND A SLOW RELEASE COMPOSITION FOR PROTEIN, POLYPEPTIDE OR PEPTIDE DRUGS AND A PRODUCTION METHOD FOR THE SAME

Номер: WO2011081406A3
Автор: YI, Yil Woong, SEO, Min Hyo, KIM, Bong Oh, CHOI, In Ja, YOON, Hye Jeong, KIM, Se Yoon, LEE, Sang Jun, CHO, Joong Woong
Принадлежит:

The present invention relates to a macromolecule for delivering protein, polypeptide or peptide drugs and to a production method for the same, as well as to a slow release composition for protein, polypeptide or peptide drugs comprising the same, and more specifically relates to a polylactic acid derivative compound of Chemical formula 1 of which the numerical average molecular weight is no more than 7000 daltons and to a production method for the same, as well as to a slow release composition for protein, polypeptide or peptide drugs using the same and to a production method for the same.

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Номер записи: 21
27-05-2010 дата публикации

POLYMER MICELLE COMPOSITION FOR TREATMENT OF RESISTANT CANCER CELLS

Номер: WO2010059001A3
Автор: KANG, Hye-Won, SEO, Min Hyo, KIM, Bong Oh
Принадлежит:

Disclosed are a polymer micelle composition for treatment of resistant cancer cells that contains an amphiphilic double block copolymer and taxane and a p-glycoprotein inhibitor of cyclosporin as its active ingredients, and a method of preparing the same. Said polymer micelle composition for treatment of cancer resistant cells is accumulated in cancer tissues at high concentrations, and has the advantages that it exhibits superior anti-cancer effects for the cancer cells that have exhibited resistance due to over-expression of p-glycoprotein by the taxane anti-cancer agent in said cancer tissues, and does not cause hypersensitive reactions due to the use of a solubilizer.

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Номер записи: 22
17-10-2019 дата публикации

LENALIDOMIDE ORAL TABLET COMPOSITION IN VARIOUS AMOUNTS

Номер: WO2019199132A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

The present invention relates to an oral tablet composition comprising lenalidomide and a method for preparing same and, more specifically, to a composition in a tablet form showing physicochemical equivalence with a lenalidomide preparation which is prepared in a hard capsule and securing equivalence in a non-clinical test and a bioequivalence test as well and thus showing equivalent pharmacological therapeutic effects, and allowing enhanced safety and easier administration and handling and the like.

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Номер записи: 23
02-04-2020 дата публикации

IMMUNOGENIC CELL DEATH INDUCING COMPOSITION

Номер: WO2020067731A1
Автор: KIM, Gyeong Hae, LEE, Sa Won, KIM, Goo Young, MOON, Gyu Young, YUN, Min Hyuk, JEONG, Seung Wei, JIN, Geun Woo, SEO, Min Hyo, JEONG, Kwang Il
Принадлежит:

Disclosed are a nano anti-cancer composition for inducing immunogenic cell death and a use thereof.

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Номер записи: 24
19-10-2017 дата публикации

보관 안정성이 향상된 약학 조성물 및 그의 제조 방법

Номер: KR0101787451B1
Автор: 김봉오, 경규진, 김지영, 김혜림, 민범찬, 윤유정, 서민효, 이일웅
Принадлежит: 주식회사 삼양바이오팜

... 특정 유연물질의 함량을 기준 이하로 포함하는 약학 조성물 및 그의 제조 방법이 제공된다.

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Номер записи: 25
08-02-2017 дата публикации

METHOD FOR ANALYZING RELATED SUBSTANCES OF PHARMACEUTICAL COMPOSITION CONTAINING POLYMERIC CARRIER

Номер: KR1020170014057A
Автор: KIM, HYE RIM, KIM, JI YEONG, MIN, BUM CHAN, SEO, MIN HYO, CHOI, HO JOON
Принадлежит:

The present invention is to provide a method for analyzing related substances in a pharmaceutical composition containing an amphiphilic block copolymer consisting of a hydrophilic block and a hydrophobic block as a drug carrier, related substances identified by the method, and a method for evaluating a pharmaceutical composition using the same. According to the present invention, impurities in a completed medicine can be precisely analyzed by using related substances of a pharmaceutical composition containing a polymeric carrier and a poorly water-soluble drug as a reference material. COPYRIGHT KIPO 2017 ...

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Номер записи: 26
17-10-2019 дата публикации

ORALLY ADMINISTERED COATED TABLET COMPOSITION OF LENALIDOMIDE

Номер: WO2019199133A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

Disclosed is a tablet-type composition, which is an oral tablet composition comprising lenalidomide, allowing enhanced safety and easier administration and handling and the like. Since a drug inside and a handler can be separated by means of a coating layer, a lenalidomide drug having teratogenicity is not present on the coating layer.

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Номер записи: 27
15-02-2019 дата публикации

음이온성 약물 함유 약제학적 조성물 및 그 제조방법

Номер: KR0101948839B1
Автор: 손지연, 김상훈, 남혜영, 김봉오, 서민효, 최지혜
Принадлежит: 주식회사 삼양바이오팜

... 유효성분으로서 음이온성 약물; 양이온성 화합물; 양친성 블록 공중합체 및 폴리락트산염을 포함하며, 상기 음이온성 약물은 상기 양이온성 지질과 복합체를 형성하고, 상기 복합체가 양친성 블록 공중합체 및 폴리락트산염이 형성하는 미셀 구조 내부에 봉입되는 것을 특징으로 하는 음이온성 약물 전달용 약제학적 조성물과 그 제조방법이 개시된다.

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Номер записи: 28
08-07-2015 дата публикации

PHARMACEUTICAL COMPOSITION NOT CONTAINING ANTIOXIDANT AND PREPARATION METHOD THEREOF

Номер: KR1020150078376A
Автор: CHO, JOONG WOONG, KIM, GYEONG HAE, SEO, MIN HYO, LEE, SA WON
Принадлежит:

Disclosed are: a composition comprising a drug such as pemetrexed in which degradation can easily occur by oxidation and having high stability by not using an antioxidant and removing oxygen from a process for preparing a composition; and a preparation method thereof. The preparation method has increased ease of preparation by freezing and degassing in a sealed container and can provide the composition having significantly increased stability of a drug which is unstable in oxidation. COPYRIGHT KIPO 2015 ...

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Номер записи: 29
24-01-2018 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING ANIONIC DRUGS AND PRODUCTION METHOD THEREOF

Номер: KR1020180008854A
Автор: SON JI YEON, KIM SANG HOON, NAM HYE YEONG, KIM BONG OH, SEO MIN HYO, CHOI JI HYE
Принадлежит:

Provided is a pharmaceutical composition for delivering anionic drugs, consisting of, as active ingredients, an anionic drug, cationic lipid, an amphiphilic block copolymer, and a polylactic acid salt. The anionic drug forms a composite with the cationic lipid, and the composite is encapsulated in a micelle structure that the amphiphilic block copolymer and the polylactic acid salt form. Moreover, disclosed is a production method thereof. COPYRIGHT KIPO 2018 (AA) Anionic drug (BB) Cationic compound (CC) Amphiphilic block copolymer (DD) Polylactate (EE) Anionic drug / cationic compound complex (FF) Anionic drug / cationic lipid / amphiphilic block polymer / polylactic acid micelle ...

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Номер записи: 30
28-06-2017 дата публикации

METHOD FOR PRODUCING POLYMERIC MICELLE CONTAINING ANIONIC DRUG

Номер: KR1020170073528A
Автор: NAM, HYE YEONG, KIM, SANG HEE, SEO, MIN HYO, SON, JI YEON
Принадлежит:

The present invention relates to a production method ensuring an increase in production yield for an anionic drug delivery composition by increasing electrostatic attraction and hydrophobic bonds, ultimately increasing encapsulation rate for anionic drugs in formulation. To this end, the production method comprises the following steps: forming nanoparticles in water using electrostatic attraction between the anionic drug and a cationic compound under an aqueous condition; and encapsulating the nanoparticles in a polymeric micelle consisting of an amphiphilic polymer and random polylactic acid salt. COPYRIGHT KIPO 2017 (AA) Anionic drug (BB) Cationic lipid (CC) Anionic drug/Cationic lipid complex (DD) Amphiphilic block polymer (EE) Polylactic acid salt (FF) Anionic drug/Cationic lipid/Amphiphilic block polymer/Polylactic acid micelle ...

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Номер записи: 31
02-10-2018 дата публикации

고분자 담체 함유 약학 조성물 평가의 기준물질로서의 유연물질

Номер: KR0101902906B1
Автор: 김혜림, 김지영, 민범찬, 서민효, 최호준
Принадлежит: 주식회사 삼양바이오팜

... 친수성 블록과 소수성 블록으로 구성된 양친성 블록 공중합체를 약물용 담체로서 함유하는 약학 조성물 내의 유연물질을 분석하는 방법, 이에 의해 동정된 유연물질, 및 이를 이용한 약학 조성물의 평가 방법이 제공된다.

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Номер записи: 32
07-07-2016 дата публикации

POLYMER NANOPARTICLE FREEZE-DRIED PRODUCT, AND PREPARATION METHOD THEREFOR

Номер: WO2016108534A1
Автор: LEE, Sa Won, KIM, Gyeong Hae, SEO, Min Hyo
Принадлежит:

The present invention relates to a polymer nanoparticle freeze-dried product, and a preparation method therefor, the polymer nanoparticle freeze-dried product being obtainable by treating, through a freeze-drying process comprising an annealing step, a polymer nanoparticle aqueous solution comprising an amphiphilic block copolymer, a polylactic acid derivative having a carboxyl terminal group, and a freeze-drying adjuvant, wherein the polymer nanoparticle freeze-dried product is reconstituted within five minutes upon reconstitution by means of an aqueous solvent under atmospheric pressure.

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Номер записи: 33
08-11-2018 дата публикации

COMPOSITION HAVING IMPROVED WATER SOLUBILITY AND BIOAVAILABILITY

Номер: WO2018203636A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

Disclosed are: a composition having improved water solubility and bioavailability, containing sorafenib and a polymethacrylate copolymer; and a preparation method therefor.

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Номер записи: 34
23-03-2017 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING ANIONIC DRUG, AND PREPARATION METHOD THEREFOR

Номер: WO2017048018A1
Автор: NAM, Hye Yeong, KIM, Bong-Oh, SEO, Min-Hyo, SON, Ji-Yeon, CHOI, Ji-Hye, KIM, Sang Hoon
Принадлежит:

Disclosed are a pharmaceutical composition for anionic drug delivery, and a preparation method therefor, the pharmaceutical composition for anionic drug delivery containing: an anionic drug as an active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the anionic drug formed a complex with the cationic lipid, and the complex is encapsulated within a micelle structure formed by the amphiphilic block copolymer and the polylactate.

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Номер записи: 35
07-07-2011 дата публикации

POLYMER NANOPARTICLE INJECTION FORMULATION COMPOSITION CONTAINING RAPAMYCIN WITH IMPROVED WATER SOLUBILITY, PREPARATION METHOD THEREOF, AND ANTICANCER COMPOSITION FOR COMBINED USE WITH RADIOTHERAPY

Номер: WO2011081430A3
Автор: KANG, Hye Won, SEO, Min Hyo, LEE, Sa Won, KIM, Bong Oh, CHOI, Eun Kyung, JEONG, Seong Yun, WOO, Ha Na
Принадлежит:

The present invention relates to a polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, and more specifically, to an injection formulation composition containing rapamycin wherein water solubility is improved by solubilizing rapamycin having low water solubility with polymer nanoparticles, a preparation method thereof, and an anticancer composition for a combined use with radiotherapy.

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Номер записи: 36
01-12-2016 дата публикации

STABILIZED PHARMACEUTICAL COMPOSITION AND METHOD FOR PREPARING SAME

Номер: WO2016190712A3
Автор: CHO, Joong-Woong, KIM, Gyeong-Hae, SEO, Min-Hyo, LEE, Sa-Won
Принадлежит:

Relating to the preparation of a composition including a drug such as pemetrexed which is easily degraded through oxidation, disclosed are a composition having increased stability by removing oxygen during the process of preparation of and to a method of preparing same. The preparation method is made easier by freezing and degassing in a sealed chamber, and therefore the preparation method can provide a composition having remarkably increased stability of an oxidation-labile drug.

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Номер записи: 37
08-02-2017 дата публикации

PHARMACEUTICAL COMPOSITION HAVING IMPROVED STORAGE STABILITY AND PRODUCTION METHOD THEREOF

Номер: KR1020170015200A
Автор: KIM, BONG OH, KYUNG, KYU JIN, KIM, JI YEONG, KIM, HYE RIM, MIN, BUM CHAN, YOON, YOO JEONG, SEO, MIN HYO, YI, YIL WOONG
Принадлежит:

Provided are a pharmaceutical composition comprising a content of a specific soft substance below standard, which can improve storage stability by inhibiting the production of a soft substance, and a production method thereof. COPYRIGHT KIPO 2017 (AA) Comparative example 1-0d (BB) Comparative example 1-3w (CC) Example 1-0d (DD) Example 1-3w (EE) Example 2-0d (FF) Example 2-3w ...

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Номер записи: 38
07-07-2011 дата публикации

POLYMER NANOPARTICLE INJECTION FORMULATION COMPOSITION CONTAINING RAPAMYCIN WITH IMPROVED WATER SOLUBILITY, PREPARATION METHOD THEREOF, AND ANTICANCER COMPOSITION FOR COMBINED USE WITH RADIOTHERAPY

Номер: KR2011081430A2
Автор: KANG, Hye Won, SEO, Min Hyo, LEE, Sa Won, KIM, Bong Oh, CHOI, Eun Kyung, JEONG, Seong Yun, WOO, Ha Na
Принадлежит:

The present invention relates to a polymer nanoparticle injection formulation composition containing rapamycin with improved water solubility, and more specifically, to an injection formulation composition containing rapamycin wherein water solubility is improved by solubilizing rapamycin having low water solubility with polymer nanoparticles, a preparation method thereof, and an anticancer composition for a combined use with radiotherapy.

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Номер записи: 39
22-06-2018 дата публикации

음이온성 약물을 함유하는 고분자 미셀의 제조방법

Номер: KR0101870316B1
Автор: 남혜영, 김상희, 서민효, 손지연
Принадлежит: 주식회사 삼양바이오팜

... 본 발명은 수상에서 음이온성 약물과 양이온성 화합물을 정전기적 결합을 이용하여 나노입자를 형성시키는 단계; 및 상기 나노입자를 양친성 고분자 및 임의로 폴리락트산염으로 이루어진 고분자 미셀 안에 포함시키는 단계를 포함함으로써, 정전기적 결합과 소수성 결합을 증가시켜 제형의 음이온 약물 봉입률을 높임으로써 음이온성 약물 전달용 조성물의 제조 수득률을 증가시키는 제조 방법에 관한 것이다.

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Номер записи: 40
07-12-2016 дата публикации

STABILIZED PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD THEREOF

Номер: KR1020160139514A
Автор: CHO, JOONG WOONG, KIM, GYEONG HAE, SEO, MIN HYO, LEE, SA WON
Принадлежит:

Disclosed is a composition which increases stability by removing oxygen when manufacturing the composition comprising a drug easily decomposed by oxidation, such as pemetrexed. Also, disclosed is a manufacturing method thereof. The manufacturing method increases availability for manufacture by performing freezing and deaerating in a sealed chamber, and can provide a composition significantly increasing stability of a drug which is unstable with respect to oxidation. COPYRIGHT KIPO 2016 ...

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Номер записи: 41
20-06-2013 дата публикации

MULTIBLOCK-COPOLYMER AQUEOUS SOLUTION COMPOSITION WITH IMPROVED-STABILITY

Номер: WO2013089491A1
Автор: KIM, Bong-Oh, SEO, Min-Hyo
Принадлежит:

The present invention relates to: an aqueous solution composition wherein the stability of the sol state of a multiblock-copolymer having sol-gel transition characteristics can be improved; and a stabilisation method therefor. More specifically, the present invention relates to: a multiblock-copolymer aqueous solution composition for refrigerated storage, which comprises a multiblock copolymer dissolved in distilled water or a buffer solution, and in which the multiblock copolymer has a molecular weight reduced by no more than 30% when stored for 2 years; and a stabilisation method therefor.

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Номер записи: 42
17-10-2019 дата публикации

LENALIDOMIDE ORAL TABLET COMPOSITION ENABLING ENHANCED DISINTEGRATION

Номер: WO2019199136A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

An orally disintegrating lenalidomide tablet is disclosed.

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Номер записи: 43
14-04-2017 дата публикации

고분자 담체 함유 약학 조성물의 유연물질 분석 방법

Номер: KR0101726728B1
Автор: 김혜림, 김지영, 민범찬, 서민효, 최호준
Принадлежит: 주식회사 삼양바이오팜

... 친수성 블록과 소수성 블록으로 구성된 양친성 블록 공중합체를 약물용 담체로서 함유하는 약학 조성물 내의 유연물질을 분석하는 방법, 이에 의해 동정된 유연물질, 및 이를 이용한 약학 조성물의 평가 방법이 제공된다.

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Номер записи: 44
16-11-2018 дата публикации

안정화된 약학 조성물 및 그의 제조방법

Номер: KR0101919436B1
Автор: 조중웅, 김경해, 서민효, 이사원
Принадлежит: 주식회사 삼양바이오팜

... 페메트렉시드와 같이 산화에 의한 분해가 쉽게 일어나는 약물을 포함하는 조성물의 제조에 있어서 제조공정상에서 산소를 제거하여 안정성을 높인 조성물 및 그 제조방법이 개시된다. 상기 제조방법은 밀폐된 챔버 내에서 동결 및 탈기하여 제조의 용이성을 높인 제조방법이며, 산화에 불안정한 약물의 안정성을 획기적으로 높인 조성물을 제공할 수 있다.

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Номер записи: 45
12-06-2017 дата публикации

양친성 블록 공중합체의 정제방법, 이로부터 얻어지는 양친성 블록 공중합체, 및 이를 포함하는 약학 조성물

Номер: KR0101745429B1
Автор: 김봉오, 김지영, 김혜림, 민범찬, 서민효, 이사원, 이일웅, 조중웅, 최인자
Принадлежит: 주식회사 삼양바이오팜

... 승화법에 의하여 분자량 감소를 억제하면서 양친성 블록 공중합체를 정제하는 방법, 상기 정제 방법에 의해 얻어지는 양친성 블록 공중합체, 및 상기 양친성 블록 공중합체를 포함하는 약학 조성물이 제공된다.

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Номер записи: 46
19-10-2017 дата публикации

보관 안정성이 향상된 약학 조성물 및 그의 제조 방법

Номер: KR0101787453B1
Автор: 김봉오, 경규진, 김지영, 김혜림, 민범찬, 윤유정, 서민효, 이일웅
Принадлежит: 주식회사 삼양바이오팜

... 특정 유연물질의 함량을 기준 이하로 포함하는 약학 조성물 및 그의 제조 방법이 제공된다.

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Номер записи: 47
09-07-2015 дата публикации

PHARMACEUTICAL COMPOSITION NOT CONTAINING ANTIOXIDANT AND PREPARATION METHOD THEREFOR

Номер: WO2015102315A1
Автор: CHO, Joong-Woong, KIM, Gyeong-Hae, SEO, Min-Hyo, LEE, Sa-Won
Принадлежит:

Disclosed are: a composition comprising a drug such as pemetrexed in which degradation can easily occur by oxidation, and having high stability by not using an antioxidant and removing oxygen from a process for preparing a composition; and a method for preparing the composition. The preparation method has high ease of preparation by freezing and degassing in a sealed container and can provide the composition having groundbreaking high stability of a drug which is unstable in oxidation.

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Номер записи: 48
28-11-2017 дата публикации

고분자 나노입자 동결건조물 및 그 제조방법

Номер: KR0101801566B1
Автор: 이사원, 김경해, 서민효
Принадлежит: 주식회사 삼양바이오팜

... 본 발명은 양친성 블록 공중합체, 카르복시 말단기를 가지는 폴리락트산 유도체 및 동결건조 보조제를 포함하는 고분자 나노입자 수용액을 어닐링 단계를 포함하는 동결건조과정으로 처리하여 얻어지며, 대기압 상태에서 수성 용매로 재건하였을 때 5분 이내에 재건되는, 고분자 나노입자 동결건조물 및 그 제조방법에 관한 것이다.

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Номер записи: 49
09-05-2019 дата публикации

ORAL SORAFENIB NANOPARTICLE COMPOSITION HAVING IMPROVED WATER SOLUBILITY AND BIOAVAILABILITY, AND PREPARATION METHOD THEREFOR

Номер: WO2019088662A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Jae Young, SEO, Min Hyo, LEE, Sa Won, KANG, Si On, LEE, Won Suk
Принадлежит:

Disclosed are an oral composition comprising sorafenib nanoparticles and having improved water solubility and bioavailability, and a preparation method therefor.

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Номер записи: 50
12-11-2018 дата публикации

COMPOSITION WITH IMPROVED WATER SOLUBILITY AND BIOAVAILABILITY

Номер: KR1020180122282A
Автор: PARK SANG YEOB, LIM HYE JUNG, LEE SA WON, SEO MIN HYO
Принадлежит:

Disclosed are a composition which contains sorafenib and a polymethacrylate copolymer and ensures improved water solubility and bioavailability, and a production method thereof. COPYRIGHT KIPO 2018 (AA) Dissolution rate (%) (BB) Example 2 (CC) Nexavar tab ...

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Номер записи: 51
01-07-2010 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING AN ANIONIC DRUG, AND A PRODUCTION METHOD THEREFOR

Номер: WO2010074540A2
Автор: KIM, Se-Ho, SON, Ji-Yeon, LA, Muhn-Ho, CHOI, Sung-Won, SEO, Min-Hyo
Принадлежит:

Disclosed is a pharmaceutical composition containing an anionic drug, characterised in that it comprises: an anionic drug as an active component; a cationic lipid; and an amphiphilic block copolymer, and in that the anionic drug forms a complex with the cationic lipid, and the complex is enclosed within a micelle structure of the amphiphilic block copolymer. Also disclosed is a production method for this pharmaceutical composition. The pharmaceutical composition is advantageous in that it can improve the efficacy of anionic drugs since it allows delivery into cells and it can increase the stability of anionic drugs in the blood or in body fluids.

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Номер записи: 52
12-07-2016 дата публикации

POLYMERIC NANOPARTICLE LYOPHILIZATE AND PRODUCING METHOD THEREOF

Номер: KR1020160083803A
Автор: LEE, SA WON, KIM, GYEONG HAE, SEO, MIN HYO
Принадлежит:

The present invention relates to a polymer nanoparticle lyophilizate and a producing method thereof. The polymer nanoparticle lyophilizate is obtained by a freeze-drying process comprising a step of annealing a polymer nanoparticle solution including an amphiphilic block copolymer, a polylactic acid derivative having a carboxyl terminal group, and a freeze-drying adjuvant, and is reconstituted within five minutes when being reconstituted by means of an aqueous solvent under atmospheric pressure. COPYRIGHT KIPO 2016 (AA) Reconstruction time(Minute) (BB) Comparative example 1 (CC) Example 1 ...

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Номер записи: 53
23-03-2017 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING ANIONIC DRUGS AND PRODUCTION METHOD THEREOF

Номер: KR1020170032858A
Автор: NAM, HYE YEONG, KIM, BONG OH, SEO, MIN HYO, SON, JI YEON, CHOI, JI HYE, KIM, SANG HOON
Принадлежит:

Disclosed are a pharmaceutical composition for delivering anionic drugs, and a production method thereof. According to the present invention, the pharmaceutical composition comprises, as an active ingredient, the anionic drug, a cationic compound, an amphiphilic block copolymer, and polylactate. The anionic drug forms a composite with the cationic lipid, and the composite is encapsulated in a micelle structure made of the amphiphilic block copolymer and the polylactate. COPYRIGHT KIPO 2017 (AA) Anionic drug (BB) Cationic compound (CC) Amphiphilic block copolymer (DD) Polylactate (EE) Anionic drug and cationic compound complex (FF) Anionic drug, cationic lipid, amphiphilic block copolymer, and polylactate micelle ...

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Номер записи: 54
07-05-2020 дата публикации

ORAL FORMULATION COMPRISING SUNITINIB AND PREPARATION METHOD THEREFOR

Номер: WO2020091439A1
Автор: LIM, Hye Jung, PARK, Sang Yeob, CHOI, In Ja, SEO, Min Hyo, LEE, Sa Won, LEE, Jae Young
Принадлежит:

The present invention relates to an oral formulation comprising sunitinib and a preparation method therefor and, more specifically, to an oral solid formulation in a capsule form, which employs a sunitinib free base and is further improved in convenience of administration, ease of handling, and safety while being physicochemically and pharmacologically equivalent to or greater than conventional hard capsule formulations comprising sunitinib malate, and a preparation method therefor.

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Номер записи: 55
06-07-2017 дата публикации

METHOD FOR SELECTIVELY SYNTHESIZING CATIONIC LIPIDS

Номер: WO2017116188A3
Автор: CHOI, Sungwon, NAM, Hye Yeong, SEO, Min-Hyo
Принадлежит:

The present invention relates to a method capable of selectively synthesizing cationic lipids by adjusting the introduction rate of a fatty acid group with respect to an oligoalkyleneamine by the change of a reaction condition.

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Номер записи: 56
07-07-2011 дата публикации

MACROMOLECULE FOR DELIVERING PROTEIN, POLYPEPTIDE OR PEPTIDE DRUGS AND A PRODUCTION METHOD FOR THE SAME, AND A SLOW RELEASE COMPOSITION FOR PROTEIN, POLYPEPTIDE OR PEPTIDE DRUGS AND A PRODUCTION METHOD FOR THE SAME

Номер: KR2011081406A2
Автор: YI, Yil Woong, SEO, Min Hyo, KIM, Bong Oh, CHOI, In Ja, YOON, Hye Jeong, KIM, Se Yoon, LEE, Sang Jun, CHO, Joong Woong
Принадлежит:

The present invention relates to a macromolecule for delivering protein, polypeptide or peptide drugs and to a production method for the same, as well as to a slow release composition for protein, polypeptide or peptide drugs comprising the same, and more specifically relates to a polylactic acid derivative compound of Chemical formula 1 of which the numerical average molecular weight is no more than 7000 daltons and to a production method for the same, as well as to a slow release composition for protein, polypeptide or peptide drugs using the same and to a production method for the same.

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Номер записи: 57
23-04-2020 дата публикации

ORAL COMPOSITION CONTAINING APREPITANT

Номер: WO2020080875A1
Автор: PARK, Sang Yeob, LEE, Sa Won, LEE, Jae Young, LIM, Hye Jung, SEO, Min Hyo
Принадлежит:

Disclosed are: an oral composition having improved water solubility and bioavailability, and obtained by forming a solid dispersion of Aprepitant, which is a poorly water-soluble drug, with a solubilizing polymer; and a method for preparing same.

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Номер записи: 58
01-07-2010 дата публикации

PHARMACEUTICAL COMPOSITION CONTAINING AN ANIONIC DRUG, AND A PRODUCTION METHOD THEREFOR

Номер: WO2010074540A3
Автор: KIM, Se-Ho, SON, Ji-Yeon, LA, Muhn-Ho, CHOI, Sung-Won, SEO, Min-Hyo
Принадлежит:

Disclosed is a pharmaceutical composition containing an anionic drug, characterised in that it comprises: an anionic drug as an active component; a cationic lipid; and an amphiphilic block copolymer, and in that the anionic drug forms a complex with the cationic lipid, and the complex is enclosed within a micelle structure of the amphiphilic block copolymer. Also disclosed is a production method for this pharmaceutical composition. The pharmaceutical composition is advantageous in that it can improve the efficacy of anionic drugs since it allows delivery into cells and it can increase the stability of anionic drugs in the blood or in body fluids.

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Номер записи: 59
08-02-2017 дата публикации

PHARMACEUTICAL COMPOSITION HAVING IMPROVED STORAGE STABILITY AND PRODUCTION METHOD THEREOF

Номер: KR1020170015199A
Автор: KIM, BONG OH, KYUNG, KYU JIN, KIM, JI YEONG, KIM, HYE RIM, MIN, BUM CHAN, YOON, YOO JEONG, SEO, MIN HYO, YI, YIL WOONG
Принадлежит:

Provided are a pharmaceutical composition comprising a content of a specific soft substance below standard, which can improve storage stability by inhibiting the production of a soft substance, and a production method thereof. COPYRIGHT KIPO 2017 (AA) Comparative example 1-0d (BB) Comparative example 1-3w (CC) Example 1-0d (DD) Example 1-3w (EE) Example 2-0d (FF) Example 2-3w ...

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Номер записи: 60
20-06-2013 дата публикации

COMPOSITION OF AN AQUEOUS SOLUTION OF POLYMERIC NANOPARTICLES AND METHOD FOR PREPARING SAME

Номер: WO2013089394A2
Автор: LEE, Sa-Won, CHO, Joong-Woong, KIM, Gyeong-Hae, SEO, Min-Hyo
Принадлежит:

Disclosed are a pharmaceutical composition including a polymeric drug carrier having enhanced stability in an aqueous solution and a method for stabilizing same. More particularly, a pharmaceutical composition in the form of an aqueous solution and a method for stabilizing same are disclosed, wherein the pharmaceutical composition maintains preservation stability for at least six months, and preferably at least 12 months in the case of refrigeration, and includes a polymeric drug carrier containing an amphiphilic block copolymer, which is composed of a hydrophilic block and a hydrophobic block, and a polylactic acid derivative of which a bivalent or trivalent metal ion binds to a carboxyl group at a terminal thereof.

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Номер записи: 61
19-04-2018 дата публикации

LENALIDOMIDE ORAL TABLET COMPOSITION

Номер: WO2018070671A1
Автор: PARK, Sang Yeob, LIM, Hye Jung, LEE, Sa Won, SEO, Min Hyo
Принадлежит:

The present invention relates to an oral tablet composition containing lenalidomide, and a preparation method therefor, and more specifically, to: a tablet form composition, which exhibits physiochemical equivalence to a lenalidomide preparation having been prepared as a hard capsule, and has further improved convenience of administration, handling, safety, and the like while exhibiting pharmacological therapeutic effects equivalent to those of the hard capsule by also ensuring equivalence in nonclinical and bioequivalence tests; and a preparation method therefor.

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Номер записи: 62