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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 13. Отображено 13.
20-07-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING THIORIDAZINE AND TRAIL AS ACTIVE COMPONENTS

Номер: KR101538264B1
Автор: KWON, TAEG KYU, MIN, KYOUNG JIN, SEO, BO RAM, WOO, SEON MIN
Принадлежит: INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY

The present invention relates to a pharmaceutical composition for preventing or treating a cancer containing thioridazine and trail as active components. More specifically, as low density thioridazine increases a production of active oxygen species in a cell and activates an proteolytic enzyme, the present invention enables to overcome a tolerance to the trail of a cancer cell and to effectively increase cell death by the trail by suppressing Akt phosphoric acid and decreasing a realization of c-FLIP (L) and Mcl-1. According to the present invention, the pharmaceutical composition or concomitant administration containing the thioridazine and the trail as the active components enables to improve an anticancer activity for the cancer cell. COPYRIGHT KIPO 2015 ...

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Номер записи: 1
04-07-2019 дата публикации

COMPOSITION FOR DIAGNOSIS AND TREATMENT OF ALCOHOLIC LIVER DISEASE, USING CHANGE IN SHORT-CHAIN FATTY ACID PRODUCING GUT BACTERIAL COMMUNITY

Номер: WO2019066577A3
Автор: KO, Gwangpyo, SEO, Bo Ram, KIM, Woon Ki, JEON, Kyung Chan
Принадлежит:

The present invention relates to a bacterial strain capable of serving as a biomarker for alcoholic fatty liver and a pharmaceutical composition for preventing or treating alcoholic fatty liver, a food composition for preventing or alleviating alcoholic fatty liver, or a probiotics composition for preventing or alleviating alcoholic fatty liver, each composition comprising the bacterial strain as an effective ingredient.

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Номер записи: 2
04-04-2019 дата публикации

COMPOSITION FOR DIAGNOSIS AND TREATMENT OF ALCOHOLIC LIVER DISEASE, USING CHANGE IN SHORT-CHAIN FATTY ACID PRODUCING GUT BACTERIAL COMMUNITY

Номер: WO2019066577A2
Автор: KO, Gwangpyo, SEO, Bo Ram, KIM, Woon Ki, JEON, Kyung Chan
Принадлежит:

The present invention relates to a bacterial strain capable of serving as a biomarker for alcoholic fatty liver and a pharmaceutical composition for preventing or treating alcoholic fatty liver, a food composition for preventing or alleviating alcoholic fatty liver, or a probiotics composition for preventing or alleviating alcoholic fatty liver, each composition comprising the bacterial strain as an effective ingredient.

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Номер записи: 3
03-01-2017 дата публикации

m-TOR 복합체 1,2 억제제 및 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 조성물

Номер: KR0101692150B1
Автор: 권택규, 민경진, 서보람
Принадлежит: 계명대학교 산학협력단

... 본 발명은 m-TOR 복합체 1, 2 억제제에서 선택된 하나 이상과 커큐민을 유효성분으로 포함하는 신장암 예방 또는 치료용 약학 조성물 및 예방 또는 개선용 건강식품 조성물에 관한 것으로, m-TOR 복합체 1, 2 억제제인 PP242와 커큐민을 다양한 신장암 세포에 병용처리할 시 핵 내 염색질과 세포질의 히스톤 관련 DNA 단편이 손상되고, 카스파제-3(caspase-3)의 활성이 증가되며 세포사멸이 증가되므로, 신장암의 예방 또는 치료에 유용하게 사용될 수 있다.

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Номер записи: 4
01-06-2017 дата публикации

NIGHTGLOW RUBBER BAND

Номер: KR1020170060272A
Автор: SEO, BO RAM
Принадлежит:

The present invention relates to a nightglow rubber band, which is designed to form a nightglow pigment on a rubber band and attach the same to a basketball ball so that basketball at night can be enjoyed. COPYRIGHT KIPO 2017 ...

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Номер записи: 5
05-03-2018 дата публикации

PRODUCTION METHOD OF ISOTHIAZOLE DERIVATIVE

Номер: KR101834224B1
Автор: LEE, PHIL HO, SEO, BO RAM, KIM, YA GOB
Принадлежит: KNU-INDUSTRY COOPERATION FOUNDATION

The present invention relates to a production method of an isothiazole derivative. More specifically, the production method of the isothiazole derivative of the present invention which can obtain 3-substituted isothiazole derivatives by intermolecular cyclization reaction or 3,4-linked isothiazole derivatives by intramolecular cyclization reaction in the presence of a chloro(1,5-cyclooctadiene)rhodium(I)dimer catalyst and 1,1′-bis(diphenylphosphino)ferrocene, with high selectivity and yield in a very effective way. COPYRIGHT KIPO 2018 ...

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Номер записи: 6
24-05-2016 дата публикации

NOVEL FLUORENE DERIVATIVE AND METHOD FOR PRODUCING SAME

Номер: KR101623704B1
Автор: LEE, PHIL HO, SEO, BO RAM, JEON, WOO HYUNG
Принадлежит: KNU-INDUSTRY COOPERATION FOUNDATION

The present invention relates to a novel effective fluorene derivative represented by chemical formula 1 and capable of being used as an organic electronic material and a bioactive substance, and a method for producing the same. In chemical formula 1, L, R^1, R^2, R^3, R^6, and R^7 are the same as defined in the detailed descriptions of the present invention. COPYRIGHT KIPO 2016 ...

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Номер записи: 7
30-09-2022 дата публикации

락토바실러스 파라카제이 균주 및 그 용도

Номер: KR102448946B1
Автор: 고광표, 김운기, 장유진, 서보람, 이준철, 남태욱, 김인수, 이진우
Принадлежит: 주식회사 고바이오랩

... 본 발명은 인간 유래의 신규한 프로바이오틱인 락토바실러스 파라카제이 KBL382 균주, 락토바실러스 파라카제이 KBL384 균주, 또는 락토바실러스 파라카제이 KBL385 균주와, 상기 균주의 장 건강 개선 및 장질환의 치료 또는 예방 용도에 관한 것으로, 본 발명에 따른 균주는 항염증 및 면역조절 기능이 우수하고, 장관벽 밀착연접의 강화 효과가 탁월하며, 장염에 따른 체중 감소 및 대장 길이의 감소를 억제하여 장염 치료 효과를 발휘할 뿐만 아니라, 아토피 피부염에 대한 증상을 현저히 개선하는바, 항염 효과 증진, 면역력 강화, 장 건강 기능 개선 및 알레르기 질환 개선을 위한 프로바이오틱 소재로 유용하게 활용될 수 있다.

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Номер записи: 8
05-01-2017 дата публикации

카뎁신 B 억제제 또는 카뎁신 D 억제제와 트레일을 유효성분으로 함유하는 암 예방 또는 치료용 조성물

Номер: KR0101693110B1
Автор: 권택규, 민경진, 서보람
Принадлежит: 계명대학교 산학협력단

... 본 발명은 카뎁신 B(Cathepsin B) 억제제 또는 카뎁신 D(Cathepsin D) 억제제에서 선택된 하나 이상을 포함하는 트레일 내성을 극복할 수 있는 약학 조성물, 항암 효과 증진용 약학 조성물 및 암세포 사멸 증진 방법에 관한 것으로, 본 발명에 따르면 카뎁신 B 억제제인 E64D 또는 카뎁신 D 억제제인 펩스타틴 A와 트레일을 신장암, 유방암 및 신경교종 중 어느 하나의 암세포에 병용투여한 경우 폴리(ADP-리보오스)중합효소[(Poly(ADP-Ribose)Polymerase, PARP]의 분열이 증가되며, Bcl-xL이 감소되며 트레일에 의한 암세포의 세포사멸이 증대되므로 신장암, 유방암 및 신경교종의 예방 또는 치료에 유용하게 사용할 수 있다.

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Номер записи: 9
06-09-2016 дата публикации

COMPOSITION COMPRISING CATHEPSIN S INHIBITOR AND TRAIL AS ACTIVE INGREDIENTS FOR PREVENTING OR TREATING CANCER

Номер: KR101654466B1
Автор: KWON, TAEG KYU, MIN, KYOUNG JIN, SEO, BO RAM
Принадлежит: INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY

The present invention relates to a pharmaceutical composition and a pharmaceutical composition for enhancing anti-cancer effects, comprising a cathepsin S inhibitor, which can overcome TRAIL resistance, and to a method for promoting cancer cell death. When Z-FL-COCHO, which is a cathepsin S inhibitor, and TRAIL are concomitantly administered to any one of cancer cells among kidney cancer, breast cancer and glioma, the differentiation of Poly(ADP-Ribose)Polymerase (PARP) increases, Bcl-2 and c-FLIP(L), which is an inhibitor of apoptosis protein (IAP) decreases, and TRAIL-induced apoptosis of cancer cells increases. Thus, the compositions of the present invention can be beneficially used for preventing or treating kidney cancer, breast cancer and glioma. COPYRIGHT KIPO 2016 ...

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Номер записи: 10
14-11-2019 дата публикации

LACTOBACILLUS PARACASEI STRAIN AND USE THEREOF

Номер: WO2019216662A1
Автор: KO, Gwang Pyo, KIM, Woonki, JANG, Wou-Jin, SEO, Boram, LEE, June-Chul, NAM, Tae-Wook, KIM, Insu, LEE, Jin- Woo
Принадлежит:

The present invention pertains to: a novel human-derived probiotic strain that is Lactobacillus paracasei KBL382, Lactobacillus paracasei KBL384, or Lactobacillus paracasei KBL385; and a use of the strain for improving intestinal health and treating or preventing intestinal diseases. The strain according to the present invention has excellent anti-inflammatory and immunomodulatory functions, has a superb strengthening effect on tight junctions of the intestinal tract wall, suppresses enteritis-induced weight loss and colon length reduction, thereby exhibiting a therapeutic effect for enteritis, and significantly alleviates the symptoms of atopic dermatitis. Therefore, the strain can be useful as a probiotic material for enhancing anti-inflammatory effects, strengthening immunity, improving intestinal health functions, and alleviating allergic diseases.

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Номер записи: 11
17-11-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING CATHEPSIN B INHIBITOR OR CATHEPSIN D INHIBITOR AND TRAIL AS ACTIVE CONSTITUENT

Номер: KR1020160132222A
Автор: KWON, TAEG KYU, MIN, KYOUNG JIN, SEO, BO RAM
Принадлежит:

The present invention relates to a pharmaceutical composition for overcoming trail resistance comprising at least one selected from a cathepsin B inhibitor or a cathepsin D inhibitor, a pharmaceutical composition for promoting an anticancer effect, and a method of promoting a cancer cell annihilation. According to the present invention, when an E64, which is a cathepsin B inhibitor, and a pepstatin and a trail, which are a cathepsin D inhibitor, are co-administered to one cancer cell of a renal cancer, breast cancer, and neuroglioma, a division of a poly (ADP-Ribose) Polymerase (PARP) is increased, Bcl-xL is decreased, and the cell annihilation of the cancer cell due to the trail is increased. Therefore, the present invention can be usefully applied to preventing and treating the renal cancer, the breast cancer, and the neuroglioma. COPYRIGHT KIPO 2016 ...

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Номер записи: 12
17-11-2016 дата публикации

COMPOSITION FOR PREVENTING OR TREATING RENAL CANCER COMPRISING INHIBITORS OF m-TOR COMPLEX 1 AND 2, AND CURCUMIN AS ACTIVE INGREDIENT

Номер: KR1020160132259A
Автор: KWON, TAEG KYU, MIN, KYOUNG JIN, SEO, BO RAM
Принадлежит:

The present invention relates to a pharmaceutical composition for preventing or treating renal cancer comprising at least one selected from inhibitors of m-TOR complex 1 and 2 and curcumin as an active ingredient, and a health food composition for preventing or alleviating renal cancer. When combined-treating PP242 which is the inhibitors of m-TOR complex 1 and 2, and the curcumin in various renal cancer cells, chromatin and cytoplasmic histone-related DNA fragments in the nucleus are damaged, cell death is increased by increasing the activity of caspase-3, thereby the PP242 and the curcumin can be helpfully used in preventing or treating renal cancer. COPYRIGHT KIPO 2016 ...

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Номер записи: 13