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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 12. Отображено 12.
28-04-2011 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: WO2011049350A3
Автор: KIM, Sung WuK, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.

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Номер записи: 1
20-12-2016 дата публикации

FcRn 특이적 인간 항체 및 이를 포함하는 자가면역질환 치료용 조성물

Номер: KR1020160145779A
Автор: 김성욱, 박승국, 정재갑, 안혜경, 김민선, 김은선, 용해영, 신동옥, 송연정, 유태형
Принадлежит:

... 본 발명은 IgG에 고친화성을 갖는 수용체인 FcRn(Neonatal Fc Receptor의 약자로, 태아 Fc-수용체, FcRP, FcRB 또는 Brambell 수용체라고도 불린다)에 특이적인 항체인 분리된 항-FcRn 항체, 이의 제조방법, 상기 항체를 포함하는 자가면역질환 치료용 조성물 및 상기 항체를 이용한 자가면역질환의 치료 및 진단 방법에 대한 것이다. 본 발명에 따른 FcRn 특이적 항체는 FcRn에 IgG와 비경합적으로 결합하여 혈중 내 병인성 자가항체의 양을 감소시킴으로써 자가면역질환(auto-immune disease)에 대한 치료에 활용 가능하다.

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Номер записи: 2
29-07-2010 дата публикации

MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND MANUFACTURING METHOD THEREOF

Номер: WO2010085086A2
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, JEONG, Jae Kap, LEE, Sung Yul, SONG, Yeon Jung, SHIM, Won Jo
Принадлежит:

The present invention provides a modified human thrombopoietin polypeptide fragment that has platelet proliferative activity in vivo and in vitro and enhanced resistance to protease existing in vivo.

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Номер записи: 3
27-11-2014 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FIBROSIS, COMPRISING N1-CYCLIC AMINE-N5-SUBSTITUTED BIGUANIDE DERIVATIVE AS ACTIVE INGREDIENT

Номер: WO2014189246A1
Автор: KIM, Sung Wuk, LEE, Soon Im, SONG, Yeon Jung, SHIN, Min Jae, OH, Kook Hwan, JU, Kyung Don, SHIN, Eun Kyoung, LEE, Ji Sun, HEO, Hye Jin, LEE, Hong Bum, KOOK, Ji Ae, KIM, Min Jeong, EUM, Hye Soun
Принадлежит:

The present invention provides a novel use of an N1-cyclic amine-N5-substituted biguanide derivative for preparing a medicine for preventing or treating fibrosis. The N1-cyclic amine-N5-substituted biguanide derivative according to the present invention is capable of effectively inhibiting fibrosis by effectively inhibiting EMT.

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Номер записи: 4
29-07-2010 дата публикации

MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND MANUFACTURING METHOD THEREOF

Номер: WO2010085086A3
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, JEONG, Jae Kap, LEE, Sung Yul, SONG, Yeon Jung, SHIM, Won Jo
Принадлежит:

The present invention provides a modified human thrombopoietin polypeptide fragment that has platelet proliferative activity in vivo and in vitro and enhanced resistance to protease existing in vivo.

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Номер записи: 5
28-06-2012 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF AND METHOD FOR PREPARING SAME

Номер: WO2012087017A2
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide or a fragment thereof which is bound to a tumor necrosis factor in vivo or ex vivo. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibits improved binding force to the tumor necrosis factor and improved protease resistance.

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Номер записи: 6
22-03-2012 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: WO2012036410A9
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to bind to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. According to the present invention, the modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof exhibits improved binding force to the tumor necrosis factor.

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Номер записи: 7
22-03-2012 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: KR2012036410A2
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to bind to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. According to the present invention, the modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof exhibits improved binding force to the tumor necrosis factor.

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Номер записи: 8
28-04-2011 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: KR2011049350A9
Автор: KIM, Sung WuK, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.

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Номер записи: 9
28-06-2012 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF AND METHOD FOR PREPARING SAME

Номер: WO2012087017A3
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide or a fragment thereof which is bound to a tumor necrosis factor in vivo or ex vivo. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibits improved binding force to the tumor necrosis factor and improved protease resistance.

Подробнее
Номер записи: 10
22-03-2012 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: WO2012036410A3
Автор: KIM, Sung Wuk, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to bind to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. According to the present invention, the modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof exhibits improved binding force to the tumor necrosis factor.

Подробнее
Номер записи: 11
28-04-2011 дата публикации

MODIFIED HUMAN TUMOR NECROSIS FACTOR RECEPTOR-1 POLYPEPTIDE OR FRAGMENT THEREOF, AND METHOD FOR PREPARING SAME

Номер: KR2011049350A2
Автор: KIM, Sung WuK, JUN, Sung Soo, PARK, Seung Kook, KIM, Song Young, KIM, Eun Sun, JEONG, Jae Kap, KIM, Ha Na, SONG, Yeon Jung
Принадлежит:

The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.

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Номер записи: 12