08-06-2017 дата публикации
Номер: KR101744900B1
The present invention relates to a stable liquid composition comprising Botulinum toxin as an active ingredient, which is ready for use without the need to undergo a reconstitution process. The liquid composition, even when the Botulinum toxin is contained in a low concentration, shows high stability by preventing coagulation of the Botulinum toxin, and is efficiently prevented from being adhered to a container, thereby allowing the activity of Botulinum toxin to remain uniform across batches or liquid vials. The liquid composition comprises (i) Botulinum toxin as an active ingredient, (ii) L-alanine or methyl cellulose, (iii) a non-ionic surfactant, and (iv) a buffer, and optionally, an isotonising agent. Since the liquid composition of Botulinum toxin of the present invention is ready for use immediately without the need to undergo a reconstitution process, the user convenience is improved, and variation in the activity of Botulinum toxin due to dilution errors during such reconstitution ...
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