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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 37. Отображено 37.
29-07-2016 дата публикации

CYLINDRICAL SPUTTERING CATHODE

Номер: KR1020160089952A
Принадлежит:

The present invention provides a cylindrical sputtering cathode comprising: a cylindrical sputtering target (10); a magnet (20) arranged in a longitudinal direction of the sputtering target (10) within the sputtering target (10), forming a magnetic field; and a magnet support unit (30) supporting the magnet (20). The magnet (20) has an opposite surface (22) facing an inner circumferential surface of the sputtering target (10) while leaving a gap (G), and the opposite surface (22) is formed to have a curvature corresponding to the inner circumference of the sputtering target (10). COPYRIGHT KIPO 2016 ...

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07-07-2015 дата публикации

METHOD OF PREPARING HYDROPHILIC POSITIVELY-CHARGED POLYMER COMPOSITE WITH HYDROPHOBIC PHOTODYNAMIC CHEMICALS, AND DRUG DELIVERY SYSTEMS USING POLYMER COMPOSITE

Номер: KR1020150076965A
Принадлежит:

The present invention relates to a method of preparing a hydrophilic positively-charged polymer composite filled with hydrophobic photodynamic chemicals, and a drug delivery system using the polymer composite, and more specifically, to a polymer composite in which a branched polyethyleneimine (bPEI) or reducible bPEI hydrophobic positively charged polymer composite is filled with pheophorbide A (PheoA) that is hydrophobic photodynamic chemicals. Also, provided is a photo-responsive anticancer composition which contains the polymer composite filled with PheoA in a hydrophilic branched positively charged polymer composite, and a drug delivery composition which contains the polymer composite filled with hydrophobic photodynamic chemicals in a hydrophilic branched positively charged polymer composite. COPYRIGHT KIPO 2015 ...

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02-07-2020 дата публикации

INTEGRATED SERVICE PLATFORM SERVER USING INTERNET OF THINGS, AND METHOD FOR PROVIDING INTEGRATED SERVICE

Номер: WO2020138828A3
Автор: YOON, Yong Ik, JO, Hana
Принадлежит:

Disclosed are: an integrated service platform server configured to integrate respective functions of a plurality of IoT devices existing in a smart home so as to provide an integrated service that is independent of the protocol or the platform of each IoT device; and a method for providing an integrated service by using the integrated service platform server.

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26-08-2015 дата публикации

Reducible polynucleotide polymer for drug delivery and method for preparing the same

Номер: KR0101547634B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 약물 전달용 환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법에 관한 것으로서, 뉴클레오타이드를 이용하여 합성된 환원성 고분자 및 이의 제조방법과, 이를 포함하는 약물 전달용 고분자 조성물을 제공한다. 뉴클레오타이드를 이용하여 다이설파이드 결합으로 잘 깨어지게 만든 환원성 고분자를 합성하여 (-)전하 고분자를 얻은 후, 이를 (+)전하 단백질이나 펩타이드와 결합시켜 정전기적 인력에 의해 단백질이나 펩타이드를 표적 부위로 전달하는 약물 전달체로서, 신규 발명된 환원성 고분자를 포함하는 비바이러스성 약물전달체에서 발명된 고분자가 수소이온 완충 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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27-08-2015 дата публикации

Composition for non-viral drug delivery comprising non-reducible polynucleotide polymer

Номер: KR0101547635B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 약물 전달용 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법에 관한 것으로서, 뉴클레오타이드를 이용하여 합성된 비환원성 고분자 및 이의 제조방법과, 이를 포함하는 약물 전달용 고분자 조성물을 제공한다. 뉴클레오타이드를 이용하여 비환원성 고분자를 합성하여 (-)전하 고분자를 얻은 후, 이를 (+)전하 단백질이나 펩타이드와 결합시켜 정전기적 인력에 의해 단백질이나 펩타이드를 표적 부위로 전달하는 약물 전달체로서, 신규 발명된 비환원성 고분자를 포함하는 비바이러스성 약물전달체에서 발명된 고분자가 수소이온 완충 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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01-06-2017 дата публикации

SHOE CASE OF STERILIZATION AND DEODORIZATION

Номер: KR101742543B1

The present invention relates to a shoe case including a sterilization and deodorization function, and more particularly, to a shoe case including an ultraviolet lamp and a deodorization stick. The shoe case of the present invention is easy to store in a shoe box, and has an effect of sterilizing both the inside and the outside of the shoe simultaneously and quickly by an ultraviolet lamp and an antibacterial gel. Also, anyone can use the shoe case easily because it is not complex to operate the shoe case. COPYRIGHT KIPO 2017 ...

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01-11-2018 дата публикации

POLY(PYRIDOXAL 5-PHOSPHATE) POLYMER HAVING ENDOSOMOLYSIS ACTIVITY AND NUCLEAR DELIVERY ACTIVITY, MANUFACTURING METHOD AND USE THEREOF

Номер: KR1020180118976A
Принадлежит:

The present invention relates to a composition having endosomolysis activity and a composition for delivering a non-virus drug which include poly(pyridoxal 5-phosphate) (pP5P), which is a polymer of a pyridoxal 5-phosphate (P5P), as an effective ingredient, or a manufacturing method of a pP5P compound. The pP5P exhibits not only endosomolysis activity but also a function to deliver a drug into a nucleus, antioxidant activity and solubility at neutral pH, so that the composition delivers a non-virus drug into a body to be usefully used as the composition for delivering a drug capable of maximizing bioavailability. COPYRIGHT KIPO 2018 ...

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31-08-2018 дата публикации

GAS SENSOR INTEGRATED WITH LIGHT, MANUFACTURING METHOD THEREOF, AND GAS DETECTION METHOD

Номер: KR1020180097464A
Принадлежит:

The present invention relates to a gas sensor integrated with light, a manufacturing method thereof, and a gas detection method. More specifically, the sensor comprises: a gas detection unit; and a light emitting diode (LED). The gas detection unit comprises: a semiconductor oxide layer responding to gas; and an electrode supplying a current to the semiconductor oxide layer to detect a change in electrical conductivity. Moreover, the LED can deliver light energy to the semiconductor oxide layer so as to amplify the electrical conductivity. Accordingly, the LED can be used at room temperature so that a highly efficient gas sensor can be provided. COPYRIGHT KIPO 2018 ...

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08-12-2017 дата публикации

칩 온 다층회로기판 제조방법

Номер: KR0101805983B1
Автор: 장헌우, 조하나, 박성달
Принадлежит: 주식회사 코리아써키트

... 본 발명은 칩이 실장되는 칩 온 실장부와, 내층회로패턴이 형성된 내층회로기판과, 상기 내층회로기판의 상,하면에 각각 접합되어, 상기 칩 온 실장부를 제외한 내층회로기판의 상,하면을 절연하는 절연층과, 상기 절연층의 표면에 형성되는 외층회로패턴층와, 상기 외층회로패턴층의 표면에 부분적으로 도포되어, 상기 외층회로패턴층의 표면을 방청하는 방청막을 포함하는데, 상기 내층회로기판의 상,하면에 각각 접합된 절연층의 표면에 단면 동박적층판(CCL)을 접합하고, 상기 단면 동박적층판(CCL)의 동박을 외층회로에 대응하는 패턴으로 식각하여 외층회로패턴을 형성하여, 상기 절연층의 표면에 단면 동박적층판(CCL)이 접합함에 따라 와피지(warpage) 발생이 억제되어, 종래의 다층회로기판보다 평탄도가 개선된 칩 온 다층회로기판 제조방법을 제공한다.

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28-05-2018 дата публикации

METHOD FOR MANUFACTURING COMPOSITION OF FERMENTED SOYBEAN PRODUCTS AND COMPOSITION OF FERMENTED SOYBEAN PRODUCTS MANUFACTURED BY METHOD

Номер: KR1020180056397A
Принадлежит:

The present application relates to a method for manufacturing a composition of fermented soybean products and to a composition of fermented soybean products manufactured by the method. Compared to fermented soybean products manufactured by a conventional sterilization method, the fermented soybean products manufactured by the method of the present invention are clear and bright, and maintain physical properties or flowability despite the addition of water or direct steam. COPYRIGHT KIPO 2018 (AA) Cooking pot ...

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23-08-2017 дата публикации

칩 온 다층회로기판 및 그 제조방법

Номер: KR0101770215B1
Автор: 장헌우, 조하나, 박성달
Принадлежит: 주식회사 코리아써키트

... 본 발명은 칩이 실장되는 칩 온 실장부와, 내층회로패턴이 형성된 내층회로기판과, 상기 내층회로기판의 상,하면에 각각 접합되어, 상기 칩 온 실장부를 제외한 내층회로기판의 상,하면을 절연하는 절연층과, 상기 절연층의 표면에 형성되는 외층회로패턴층와, 상기 외층회로패턴층의 표면에 부분적으로 도포되어, 상기 외층회로패턴층의 표면을 방청하는 방청막을 포함하는데, 상기 내층회로기판의 칩 온 실장부 경계를 따라 레이저 드릴링으로 사이드홈을 형성하여, 상기 절연층을 내층회로기판에 열압착 방식으로 접합할 시, 용융된 절연층이 사이드홈으로 흘러들어가면서 칩이 실장되는 공간인 캐비티의 사이드월(side wall)이 형성되도록 하여, 안정적인 칩 온 실장부 확보할 수 있고, 회로기판의 두께를 종래보다 낮출 수 있으며, 캐비티 서브스트레이트(Cavity substrate)의 안정적인 수율이 가능한 칩 온 다층회로기판 및 그 제조방법을 제공한다.

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07-08-2017 дата публикации

METHOD OF MANUFACTURING CHIP-EMBEDDED CIRCUIT BOARD

Номер: KR1020170090007A
Принадлежит:

The present invention provides a method of manufacturing a chip-embedded circuit board. The method comprises: a step (a) of providing an inner layer substrate; a step (b) of forming an inner circuit pattern and a chip mounting portion on the inner layer substrate; a step (c) of mounting a chip in the chip mounting portion of the inner layer substrate; a step (d) of laminating an insulating layer on the inner layer circuit board with the chip mounted; a step (e) of forming a via hole to allow a bumper of the chip mounted on the inner layer substrate to be exposed; and a step (f) of forming an outer layer circuit pattern and a via in a surface of the insulating layer. The method is configured such that the bumper of the chip penetrates the inner layer substrate to be fixated, thereby minimizing the impact of resin flow, the range of a laser target increases due to a bumper hole through which the bumper penetrates and a conductive film formed around the bumper hole so alignment is easily achieved ...

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10-07-2018 дата публикации

CONTROL OF SMART LAMP BASED ON BIORHYTHM ANALYSIS

Номер: KR1020180078381A
Принадлежит:

According to the present invention, provided is a method of controlling a lamp in accordance with user emotion. The method comprises the following steps: checking biorhythm of a user through a sensor of a smartphone; receiving environmental information from a database of an external server wirelessly connected to the smartphone; grasping a position of the user; and controlling a lamp installed in a space including the position of the user grasped based on the biorhythm and the environment information. Therefore, the lamp can be controlled by reflecting the emotion of the user according to the biorhythm of the user and an external environment condition. COPYRIGHT KIPO 2018 ...

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16-03-2017 дата публикации

CHIP-ON MULTILAYER CIRCUIT SUBSTRATE AND MANUFACTURING METHOD THEREOF

Номер: KR1020170029691A
Принадлежит:

The present invention provides a chip-on multilayer circuit substrate. The chip-on multilayer circuit substrate includes: a chip-on mounting part mounting a chip; an inner circuit substrate formed with an inner circuit pattern; an insulating layer combined with each of the upper and lower surfaces of the inner circuit substrate to insulate the upper and lower surfaces of the inner circuit substrate except the chip-on mounting part; an outer circuit pattern layer formed on the surface of the insulating layer; and a corrosion preventing film preventing the surface of the outer circuit pattern layer from being corroded by being partially applied to the surface of the outer circuit pattern layer. A single-sided copper-laminated plate (CCL) is combined with the surface of the insulating layer combined with each of the upper and lower surfaces of the inner circuit substrate. As copper foil of the single-sided copper-laminated plate (CCL) is etched with a pattern, corresponding to an outer circuit ...

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13-10-2015 дата публикации

CONTENT RECOMMENDING METHOD

Номер: KR101559459B1

The present invention relates to a method to recommend content based on a basic preference of a user. The method includes: a step of vectorizing content into a numerical value; a step of dividing a user into virtual users, having at least one basic preference, based on the vectorized content; and a cooperative filtering step of finding a virtual user, similar to a target user, among the virtual users, and calculating a preference for the content of the target user. Therefore, the present invention is capable of providing a higher performance content recommending method by recommending the content from the preference, separated from the user. COPYRIGHT KIPO 2016 (S100) Contact vectorization (S200) Generate a virtual user (S300) Cooperative filtering ...

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25-10-2017 дата публикации

METHOD FOR REMOVING PROCESSING DEFECT OF GALLIUM NITRIDE SUBSTRATE

Номер: KR1020170118472A
Принадлежит:

The present invention provides a method for removing defects of a gallium nitride substrate capable of obtaining a flat gallium nitride surface by removing all defects from the gallium nitride substrate surface. According to an embodiment of the present invention, the method for removing a processing defect of a gallium nitride substrate comprises the following steps: removing a part of processing defects formed on the gallium nitride substrate surface by primarily and chemically etching the gallium nitride substrate surface; and removing the entire processing defects by secondarily and physically etching the gallium nitride substrate in which the part of the processing defects is removed. COPYRIGHT KIPO 2017 ...

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14-12-2015 дата публикации

Preparation method of hydrophobic photodynamic chemicals solubilized hydrophilic positively-charged polymers and drug delivery systems using the same

Номер: KR0101577264B1

... 본 발명은 소수성 광역학 약물이 봉입된 친수성 양전하성 고분자 복합체의 제조방법 및 상기 고분자 복합체를 이용한 약물전달체에 관한 것으로서, 상세하게는 가지형 폴리에틸렌이민(branched polyethyleneimine; bPEI) 또는 환원성 bPEI(reducible bPEI) 친수성 양전하성 고분자에 소수성 광역학 약물인 페오포바이드 a(pheophorbide a; PheoA)가 봉입된 고분자 복합체 및 이의 제조방법에 관한 것이다. 또한, 본 발명은 친수성 가지형 양전하성 고분자에 페오포바이드 a(pheophorbide a; PheoA)가 봉입된 고분자 복합체를 포함하는 광응답성 항암용 조성물을 제공한다. 또한, 본 발명은 친수성 가지형 양전하성 고분자에 소수성 광역학 약물이 봉입된 고분자 복합체를 포함하는 약물전달용 조성물을 제공한다.

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02-07-2020 дата публикации

INTEGRATED SERVICE PLATFORM SERVER USING INTERNET OF THINGS, AND METHOD FOR PROVIDING INTEGRATED SERVICE

Номер: WO2020138828A2
Автор: YOON, Yong Ik, JO, Hana
Принадлежит:

Disclosed are: an integrated service platform server configured to integrate respective functions of a plurality of IoT devices existing in a smart home so as to provide an integrated service that is independent of the protocol or the platform of each IoT device; and a method for providing an integrated service by using the integrated service platform server.

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24-12-2014 дата публикации

REDUCING OR NON-REDUCING POLYNUCLEOTIDE POLYMER FOR DRUG DELIVERY AND METHOD FOR PREPARING SAME

Номер: WO2014204264A1
Принадлежит:

The present invention relates to a reducing or non-reducing polynucleotide polymer for drug delivery and a method for preparing same, and provides a reducing or non-reducing polymer synthesized by using nucleotides, a method for preparing same, and a polymer composition for drug delivery containing the reducing or non-reducing polymer. The present invention relates to a drug delivery carrier for delivering proteins or peptides to a targeted area through electrostatic attraction, by obtaining a (-) charge polymer by using nucleotides to synthesize the reducing or non-reducing polymer, which is easily breakable due to disulfide bonds, and then bonding the (-) charge polymer with a (+) charge protein or peptide, wherein a polymer derived from a non-viral drug delivery carrier containing the novel reducing or non-reducing polymer is capable of effectively enabling escape of a drug, delivered by means of proton buffering activity, from an endosome to other organelles in a cell.

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27-08-2015 дата публикации

Composition for non-viral drug delivery comprising reducible polynucleotide polymer

Номер: KR0101547636B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 약물 전달용 환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법에 관한 것으로서, 뉴클레오타이드를 이용하여 합성된 환원성 고분자 및 이의 제조방법과, 이를 포함하는 약물 전달용 고분자 조성물을 제공한다. 뉴클레오타이드를 이용하여 다이설파이드 결합으로 잘 깨어지게 만든 환원성 고분자를 합성하여 (-)전하 고분자를 얻은 후, 이를 (+)전하 단백질이나 펩타이드와 결합시켜 정전기적 인력에 의해 단백질이나 펩타이드를 표적 부위로 전달하는 약물 전달체로서, 신규 발명된 환원성 고분자를 포함하는 비바이러스성 약물전달체에서 발명된 고분자가 수소이온 완충 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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05-12-2019 дата публикации

INSULATION FILM AND METHOD FOR MANUFACTURING INSULATION FILM

Номер: WO2019231028A1
Принадлежит:

The present invention relates to a thin film coated insulation film comprising a carrier film, an insulation layer formed by coating an insulation resin using the carrier film, and a B-stage adhesive layer which is on one surface of the insulation layer, and to a thin film coated insulation film having a resin solution that has insulation and adhesive functions coated on one surface of the carrier film, so that the filling ratio of a printed circuit wiring part is at least 75% and the elastic modulus is at most 15 g.f/㎠.

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25-06-2015 дата публикации

NUCLEOTIDE HAVING ENDOSOMOLYSIS ACTIVITY AND USES OF SAME

Номер: KR1020150070995A
Принадлежит:

The present invention relates to a non-viral drug delivery composition including nucleotide and a non-viral drug delivery system. The composition has hydrogen ion (proton) buffering activity or hemolysis activity, and thus induces endosomal escape of a delivered drug through endosomolysis. The present invention relates to an effective drug delivery system whereby the delivered drug can be escaped from endosome to another micro-organ in a cell by the hydrogen ion buffering activity or the hemolysis activity of nucleotide of the non-viral drug delivery composition. COPYRIGHT KIPO 2015 ...

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24-05-2018 дата публикации

METHOD FOR MANUFACTURING COMPOSITION OF FERMENTED SOYBEAN PRODUCTS AND COMPOSITION OF FERMENTED SOYBEAN PRODUCTS MANUFACTURED THEREBY

Номер: WO2018093187A1
Принадлежит:

The present application relates to a method for manufacturing a composition of fermented soybean products and a composition of fermented soybean products manufactured thereby.

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16-03-2017 дата публикации

CHIP-ON MULTI-LAYER CIRCUIT BOARD AND METHOD FOR MANUFACTURING SAME

Номер: KR1020170029690A
Принадлежит:

The present invention relates to a chip-on multi-layer circuit board and a method for manufacturing the same. Provided is the chip-on multi-layer circuit board comprising: a chip-on mounting portion in which a chip is mounted; an inner layer circuit board in which an inner layer circuit pattern is formed; insulation layers which are bonded to respective top and bottom surfaces of the inner layer circuit board, and which insulate the top and bottom surfaces of the inner layer circuit board exclusive of the chip-on mounting portion; outer layer circuit pattern layers which are formed on surfaces of the insulation layers; rust prevention films which is applied on parts of surfaces of the outer layer circuit pattern layers, and which prevent the surfaces of the outer layer circuit pattern layers from rusting; wherein a side groove is formed in the inner layer circuit board around the chip-on mounting portion through laser drilling, and melted insulation layers flowing through the side groove ...

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26-08-2015 дата публикации

Non-reducible polynucleotide polymer for drug delivery and method for preparing the same

Номер: KR0101547633B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 약물 전달용 비환원성 폴리뉴클레오타이드 고분자 및 이의 제조방법에 관한 것으로서, 뉴클레오타이드를 이용하여 합성된 비환원성 고분자 및 이의 제조방법과, 이를 포함하는 약물 전달용 고분자 조성물을 제공한다. 뉴클레오타이드를 이용하여 비환원성 고분자를 합성하여 (-)전하 고분자를 얻은 후, 이를 (+)전하 단백질이나 펩타이드와 결합시켜 정전기적 인력에 의해 단백질이나 펩타이드를 표적 부위로 전달하는 약물 전달체로서, 신규 발명된 비환원성 고분자를 포함하는 비바이러스성 약물전달체에서 발명된 고분자가 수소이온 완충 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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19-03-2025 дата публикации

METHOD AND SYSTEM FOR SLEEP CARE USING ARTIFICIAL INTELLIGENCE AND SLEEP CARE APPLICATION

Номер: KR20250038561A
Принадлежит:

... 적어도 하나의 프로세서에 의해 동작하는 단말의 동작 방법으로서, 화면에서 입력된 정보를 기초로 사용자의 정신 상태 정보를 획득하는 단계, 상기 정신 상태 정보를 서버로 전송하는 단계, 수면 케어 서비스 동안 상기 사용자의 생체 신호를 전송하는 단계, 그리고 상기 서버로부터, 상기 생체 신호와 상기 정신 상태 정보로부터 추론된 청각 자극을 수신하고, 상기 청각 자극에 해당하는 소리를 출력하는 단계를 포함한다.

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28-07-2015 дата публикации

Nucleotide having endosomolysis activity and uses thereof

Номер: KR0101539381B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 뉴클레오타이드 및 비바이러스성 약물전달체를 포함하는 비바이러스성 약물전달체 조성물에 관한 것으로서, 상기 조성물은 수소이온 완충화(proton buffering) 활성 또는 용혈(hemolysis) 활성을 가지고 있어서, 엔도좀 분해(endosomolysis)를 통한 전달 약물의 엔도솜 탈출(Endosomal escape)을 유도하는 것을 특징으로 한다. 본 발명의 비바이러스성 약물전달체 조성물은 뉴클레오타이드의 수소이온 완충 활성 또는 용혈 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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19-03-2025 дата публикации

METHOD AND SYSTEM FOR MEMORY REACTIVATION AND MEMORY REACTIVATION APPLICATION

Номер: KR20250038560A
Принадлежит:

... 적어도 하나의 프로세서에 의해 동작하는 서버의 동작 방법으로서, 학습 동안에, 학습 과제와 자극으로 구성된 콘텐츠를 사용자의 단말에게 제공하는 단계, 상기 사용자의 뇌파 신호를 기초로 추정한 수면 단계가 깊은 수면 단계이면, 상기 자극의 출력을 상기 단말에 요청하는 단계, 그리고 상기 학습 동안에 측정된 뇌파 신호와 수면 중인 상기 사용자에게 상기 자극을 제공한 후에 측정된 뇌파 신호를 비교하여, 기억 재활성화 여부를 판단하는 단계를 포함한다.

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04-10-2018 дата публикации

ASCORBIC ACID 2-PHOSPHATE AND POLYMER THEREOF HAVING ENDOSOMOLYTIC ACTIVITY AND DELIVERY ACTIVITY IN NUCLEUS, AND USES THEREOF

Номер: KR1020180108190A
Принадлежит:

The present invention relates to a composition having endosomolytic activity, a composition for non-viral drug delivery comprising an ascorbic acid 2-phosphate (AAP) or a polymer thereof (poly(ascorbic acid 2-phosphate)) (pAAP) as an active ingredient, or a method for manufacturing a poly(ascorbic acid 2-phosphate) polymer compound which is a polymer of ascorbic acid 2-phosphate. Since the AAP and pAAP exhibit not only the ability to decompose endosomes but also the function of delivering the drug into the nucleus and the antioxidant activity, the composition comprising the same can deliver the non-viral drug in vivo to maximize the bioavailability, and thus can be usefully used as a composition for a drug delivery. COPYRIGHT KIPO 2018 ...

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31-12-2015 дата публикации

Nucleotide having endosomolysis activity and uses thereof

Номер: KR0101577274B1
Автор: 강한창, 배유한, 조하나

... 본 발명은 뉴클레오타이드 및 비바이러스성 약물전달체를 포함하는 비바이러스성 약물전달체 조성물에 관한 것으로서, 상기 조성물은 수소이온 완충화(proton buffering) 활성 또는 용혈(hemolysis) 활성을 가지고 있어서, 엔도좀 분해(endosomolysis)를 통한 전달 약물의 엔도솜 탈출(Endosomal escape)을 유도하는 것을 특징으로 한다. 본 발명의 비바이러스성 약물전달체 조성물은 뉴클레오타이드의 수소이온 완충 활성 또는 용혈 활성으로 인해 전달된 약물을 엔도솜에서 세포 내 다른 소기관으로 탈출시킬 수 있는 효과적인 약물전달체에 대한 것이다.

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13-08-2015 дата публикации

COMPOSITION COMPRISING REDUCIBLE POLYNUCLEOTIDE POLYMER FOR DELIVERING NONVIRAL DRUG

Номер: KR1020150092730A
Принадлежит:

The present invention relates to a reducible polynucleotide polymer for delivering a drug and a manufacturing method thereof, and more specifically, to a reducible polymer synthesized by using nucleotide, a manufacturing method thereof, and a polymer composition comprising the same for delivering a drug. The present invention relates to an effective drug carrier, as a drug carrier for delivering a protein or a peptide to the target region by electrostatic attraction, after synthesizing a reducible polymer made to be breakable with a disulfide bond using nucleotide, obtaining a (-) electric charge polymer, and binding the same to the protein or the peptide with a (+) electric charge, wherein the polymer invented in the nonviral drug carrier comprising a newly invented reducible polymer is capable of letting the delivered drug escape by hydrogen ion buffering activity from endosome to a different organelle inside a cell. COPYRIGHT KIPO 2015 ...

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11-06-2020 дата публикации

DEVICE AND METHOD FOR CHARGING SECONDARY BATTERY

Номер: WO2020116853A1
Принадлежит:

The present invention provides a device and method for charging a secondary battery. A charging device according to the present invention comprises a control unit for receiving a measured voltage value and a measured temperature value input from a voltage measurement unit and a temperature measurement unit, respectively, and adjusting the magnitude of a charge current. The control unit determines the average ion concentration and surface ion concentration of anode particles, the anode particle potential, and the anode electrolyte potential by using an electrochemical reduced-order model. In addition, the control unit determines the charging state of a secondary battery from the average ion concentration and determines the side reaction rate from the anode particle potential and the anode electrolyte potential. Further, the control unit attenuates the magnitude of the charge current applied to a secondary battery if at least one of (i) a condition in which the measured voltage value reaches ...

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24-12-2014 дата публикации

NUCLEOTIDE CAPABLE OF ENDOSOMOLYSIS AND USE THEREOF

Номер: WO2014204240A1
Принадлежит:

The present invention relates to a non-viral drug delivery carrier composition containing a nucleotide and a non-viral drug delivery carrier, wherein the composition has proton buffering activity or hemolysis activity thereby inducing endosomal escape of a drug to be delivered through endosomolysis. The non-viral drug delivery carrier composition according to the present invention is related to an effective drug delivery carrier capable of enabling the escape of the drug that is delivered from an endosome into other organelles in a cell by means of the proton buffering activity or the hemolysis activity of the nucleotide.

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26-12-2017 дата публикации

칩 내장형 회로기판 제조방법

Номер: KR0101811941B1
Автор: 조하나, 장헌우, 전현찬
Принадлежит: 주식회사 코리아써키트

... 본 발명은 a)내층기판을 제공하는 단계와, b)상기 내층기판에 내층회로패턴 및 칩 실장부를 형성하는 단계와, c)상기 내층기판의 칩 실장부에 칩을 실장하는 단계와, d)상기 칩이 실장된 내층기판에 절연층을 적층하는 단계와, e)상기 내층기판에 실장된 칩의 범프가 노출되도록 비아홀을 형성하는 단계와, f)상기 절연층의 표면에 외층회로패턴 및 비아를 형성하는 단계가 포함되어, 칩의 범프가 내층기판을 관통하여 고정됨에 따른 레진 플로우(resin flow) 영향을 최소화하고, 범프가 관통하는 범프홀 및 범프홀에 형성된 도전피막에 의해 레이저 타겟 범위가 증가함에 따라 비아홀 가공시 얼라이먼트가 용이하여 내장된 칩의 범프(bump)와 외층회로패턴 간의 비아 연결 정도(via interconnection accuracy)가 높아짐에 따라 원가절감 및 안정적인 수율 확보할 수 있고, 내층회로패턴과 전기적으로 연결되지 않은 범프홀의 도전피막에 의해 지정 위치를 벗어난 드릴링 가공에 따른 범프와 비아 간의 공차가 발생하지 않아 불량률 최소화하며, 칩을 내장하기 위한 캐비티 가공 공정이 없어 제조공정이 간단해지고, 일괄 핫프레스 공정으로 인해 제조공정이 간단해져 제조공정에 따른 비용 절감 및 생산성을 향상시킬 수 있는 칩 내장형 회로기판 제조방법을 제공한다.

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10-09-2018 дата публикации

장류 조성물의 제조방법 및 이에 의해 제조된 장류 조성물

Номер: KR0101888314B1
Принадлежит: 씨제이제일제당 (주)

... 본 출원은 장류 조성물의 제조방법 및 이에 의해 제조된 장류 조성물에 관한 것이다.

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24-07-2018 дата публикации

FERMENTED PASTE COMPOSITION AND PRODUCTION METHOD THEREOF

Номер: KR101881706B1
Принадлежит: CJ CHEILJEDANG CORPORATION

The present invention relates to a fermented paste composition and a production method thereof. The fermented paste composition contains a fermented product obtained by fermenting a carbohydrate material using at least one strains of Candida utilis, Saccharomyces fragilis, Saccharomyces lactis and Schizosaccharomyces pombe. The present application has an effect of providing the fermented paste composition which has low content of alcohol while maintaining the flavor of exiting fermented paste compositions. COPYRIGHT KIPO 2018 (AA) Red pepper paste alcohol content (%) ...

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20-06-2019 дата публикации

FERMENTED SOYBEAN COMPOSITION AND METHOD FOR PRODUCING FERMENTED SOYBEAN COMPOSITION

Номер: WO2019117570A1
Принадлежит:

The present application relates to a fermented soybean composition and a method for producing a fermented soybean composition.

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