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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 22. Отображено 22.
03-05-2016 дата публикации

COMPOSITION FOR INHIBITING CANCER STEM CELL GROWTH AND CANCER METASTASIS COMPRISING TSPYL5 EXPRESSION OR ACTIVATION INHIBITOR AS ACTIVE INGREDIENT

Номер: KR1020160047735A
Принадлежит:

The present invention relates to a pharmaceutical composition for inhibiting cancer metastasis, which comprises a testis-specific protein, Y-encoded-like (5TSPYL5) expression or activation inhibitor as an active ingredient. After irradiating A549 cells that are non-small cell lunger cancer cells with fractionated radiation, the amount of expression of TSPYL5 and that of ALDH1 and CD44 as cancer stem cell markers are significantly increased. When expression or activation of TSPYL5 is inhibited, it is shown that the amount of expression of ALDH1 and CD44 as cancer stem cell markers is suppressed, and thus the function of EMT, an important path of cancer stem cell growth and metastasis, is significantly decreased and the growth of malignant plasma cells is inhibited. Therefore, a TSPYL5 expression or activation inhibitor can be used as an active ingredient of a composition for inhibiting cancer stem cell growth and cancer metastasis in various types of tumors. COPYRIGHT KIPO 2016 ...

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19-07-2016 дата публикации

LACTOBACILLUS PLANTARUM YD-212 STRAINS, AND COMPOSITION CONTAINING FERMENTED PRODUCT PREPARED BY USING SAME

Номер: KR1020160086249A
Принадлежит:

Provided are: Lactobacillus plantarum YD-212 strains isolated from feces of healthy Korean adults; and a composition for preventing and alleviating metabolic bone diseases or a pharmaceutical composition for treating metabolic bone diseases comprising a fermented product prepared by using the strains as an active ingredient. The fermented product prepared by using the Lactobacillus plantarum YD-212 strains promotes the proliferation and differentiation of osteoblasts, and increases bone density and bone strength, thereby being able to be usefully used for alleviating, preventing, or treating metabolic bone diseases such as osteoporosis. COPYRIGHT KIPO 2016 (AA) Bone density (BMD, mg/cm^3) (BB) Treatment group ...

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11-12-2015 дата публикации

COMPOSITION CONTAINING ETHYLACETATE-SOLUBLE EXTRACT FRACTION, SEPARATED FROM SALVIA PLEBEIA, AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING OBESITY

Номер: KR1020150139418A
Принадлежит:

The present invention relates to a composition containing a Salvia plebeia extract or a compound, selected from the group consisting of homoplantaginin, luteolin, and rosmarinic acid, which are separated from the Salvia plebeia extract, as an active ingredient for preventing and treating obesity. The Salvia plebeia extract or the compound selected from the group consisting of homoplantaginin, luteolin, and rosmarinic acid, which are separated from the Salvia plebeia extract has excellent effect of inhibiting activity of an enzyme for differentiation of a fat cell, differentiation of the fat cell, and accumulation of lipids and thus can be advantageously used to prevent or treat obesity. COPYRIGHT KIPO 2016 (AA) Weight (g) of fat tissue (BB) Normal diet group (chow) (CC) High fat diet group (HFD) (DD) Salvia plebeia extract (200 mg/kg) (EE) Liver (FF) Epididymal fat (GG) Fat around a kideny (HH) Rear abdominal fat (II) Mesenteric fat (JJ) Subcutaneous fat (KK) Total weight of fat tissue ...

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26-06-2014 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEMENTIA

Номер: WO2014098306A1
Принадлежит:

The present invention relates to an acetylcholinesterase activity inhibitor, a pharmaceutical composition for preventing and/or treating dementia, and/or a cerebral nerve protective agent containing a compound derived from Hericium erinaceus or a salt thereof, and/or preparation methods therefor.

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04-10-2012 дата публикации

COMPOSITION CONTAINING, AS AN ACTIVE INGREDIENT, AN ETHYL ACETATE FRACTION OF SCHISANDRA CHINENSIS BAILL, OR WUWEIZISU C SEPARATED FROM THE FRACTION, FOR PREVENTING OR TREATING OBESITY

Номер: WO2012134172A3
Принадлежит:

The present invention relates to a composition containing, as an active ingredient, an ethyl acetate fraction of Schisandra chinensis Baill, or wuweizisu C separated from the fraction, for preventing or treating obesity. The ethyl acetate fraction of Schisandrae chinensis Baill or wuweizisu C separated from the fraction according to the present invention has superior effects in inhibiting the differentiation of adipocytic cells and lipid accumulation, and therefore can be effectively used in preventing or treating obesity.

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12-01-2018 дата публикации

피불린-3 단백질을 유효성분으로 함유하는 폐암 전이 억제용 약학적 조성물

Номер: KR0101818187B1
Принадлежит: 한국원자력연구원

... 본 발명은 피불린-3(fibulin-3) 단백질을 유효성분으로 함유하는 폐암 전이 억제용 약학적 조성물에 관한 것으로, 더욱 구체적으로는 피불린-3 단백질에 의해서 암세포 전이의 중요한 경로 중의 하나인 EMT(epithelial-mesenchymal transition) 기능을 현저히 감소시켜 이동성 같은 세포의 운동성을 저해시킴으로써, 상기 피불린-3를 폐암 전이 억제용 약학적 조성물의 유효성분으로 유용하게 사용할 수 있다.

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26-03-2018 дата публикации

지치 유래 신규 화합물

Номер: KR0101841537B1
Принадлежит: 대한민국

... 본 발명은 신규한 화합물에 관한 것으로서, 보다 상세하게는 연골기질물질 분해효소(matrix metalloprotease; MMP)-1, MMP-3, MMP-13의 활성을 저해하고 염증으로 인한 통증을 억제하여 관절염 치료 활성을 갖는 신규 화합물; 상기 신규 화합물 또는 약학적으로 허용가능한 이의 염을 유효성분으로 포함하는 관절염 예방 또는 치료용 약학적 조성물; 상기 신규 화합물 또는 약학적으로 허용가능한 이의 염을 유효성분으로 포함하는 염증성 통증 완화 또는 억제용 약학적 조성물; 상기 신규 화합물 또는 식품학적으로 허용가능한 이의 염을 유효성분으로 포함하는 관절염 예방 또는 개선용 건강기능식품; 및 상기 신규 화합물 또는 식품학적으로 허용가능한 이의 염을 유효성분으로 포함하는 염증성 통증 완화 또는 개선용 건강기능식품에 관한 것이다.

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04-10-2012 дата публикации

COMPOSITION CONTAINING, AS AN ACTIVE INGREDIENT, AN ETHYL ACETATE FRACTION OF SCHISANDRA CHINENSIS BAILL, OR WUWEIZISU C SEPARATED FROM THE FRACTION, FOR PREVENTING OR TREATING OBESITY

Номер: WO2012134172A2
Принадлежит:

The present invention relates to a composition containing, as an active ingredient, an ethyl acetate fraction of Schisandra chinensis Baill, or wuweizisu C separated from the fraction, for preventing or treating obesity. The ethyl acetate fraction of Schisandrae chinensis Baill or wuweizisu C separated from the fraction according to the present invention has superior effects in inhibiting the differentiation of adipocytic cells and lipid accumulation, and therefore can be effectively used in preventing or treating obesity.

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04-04-2013 дата публикации

METHOD FOR DECREASING RADIORESISTANCE AND GROWTH, METASTASIS AND INFILTRATION OF CANCER CELLS THROUGH REGULATING EXPRESSION OR ACTIVITY OF TM4SF4 IN NON-SMALL CELL LUNG CANCER

Номер: WO2013047941A1
Принадлежит:

The present invention relates to a pharmaceutical composition or an anticancer agent for preventing and treating non-small cell lung cancer, containing a substance for regulating the expression or activity of transmembrane 4 L six family member 4 (TM4SF4). More specifically, the present invention relates to a use of a substance for regulating the expression or activity of TM4SF4 as an anticancer drug or an anticancer agent with respect to non-small cell lung cancer, wherein it was ascertained that it is possible to decrease the growth, metastasis and infiltration of adenocarcinoma cells and radioresistance by decreasing the expression of TM4SF4 in adenocarcinoma among non-small cell lung cancers and to decrease the growth, metastasis and infiltration of the cells and radioresistance by increasing the expression of TM4SF4 in other non-small cell lung cancers except adenocarcinoma.

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17-02-2011 дата публикации

COMPOSITION FOR PREVENTING OR TREATING ARTHRITIS, CONTAINING AN EXTRACT OF AN HERBAL MEDICINE MIXTURE OF SCHISANDRA CHINENSIS BAILLON, SCUTELLARIA BAICALENSIS AND KALOPANAX PICTUS NAKAI AS AN ACTIVE INGREDIENT

Номер: WO2011019153A3
Принадлежит:

The present invention relates to a composition for preventing or treating arthritis, containing an extract of an herbal medicine mixture of Schisandra chinensis Baillon, Scutellaria baicalensis and Kalopanax pictus Nakai as an active ingredient. The extract of an herbal medicine mixture of Schisandra chinensis Baillon, Scutellaria baicalensis and Kalopanax pictus Nakai contained in the composition of the present invention inhibits the synthesis and breakdown of extracellular matrix components of chondrocytes containing hyaluronic acid in the joint of a person, which might otherwise generally occur in the joint of a patient suffering from osteoarthritis. The extract of an herbal medicine mixture contained in the composition of the present invention relieves edema and pain which are the cardinal symptoms of arthritis. Therefore, the composition of the present invention containing the extract of an herbal medicine mixture can be effectively used in preventing or treating arthritis.

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27-09-2016 дата публикации

COMPOSITION FOR INHIBITING OR ALLEVIATING ITCHINESS, COMPRISING QUINOLINE-BASED COMPOUND

Номер: KR1020160111769A
Принадлежит:

The present invention relates to a composition for inhibiting or alleviating itchiness, comprising a quinoline-based compound and, more specifically, relates to a composition for preventing or treating various skin or systemic diseases accompanied with itchiness. The pharmaceutical composition for inhibiting or alleviating itchiness comprises a compound represented by chemical formula 1. COPYRIGHT KIPO 2016 ...

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10-05-2017 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING ASTRAGALUS PROPINQUUS EXTRACT AND LITHOSPERMUM PURPUROCAERULEUM EXTRACT FOR PREVENTING OR TREATING ARTHRITIS

Номер: KR1020170049362A
Принадлежит:

The present invention relates to a pharmaceutical composition comprising an Astragalus propinquus extract and a Lithospermum purpurocaeruleum extract for preventing or treating arthritis, and more specifically, to a pharmaceutical composition comprising an Astragalus propinquus extract and a Lithospermum purpurocaeruleum extract for preventing or treating arthritis, to health functional food for preventing or treating arthritis, which inhibits activation of matrix metalloprotease (MMP)-1, MMP-3, MMP-13, and inhibits pain due to inflammation, so as to have activation of preventing or treating arthritis. Moreover, the present invention also relates to a composition for reducing or inhibiting inflammatory pain, and to health functional food for reducing or improving inflammatory pain. COPYRIGHT KIPO 2017 ...

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18-02-2016 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING SUBSTANCE DERIVED FROM ASTRAGALI RADIX FOR PREVENTING OR TREATING ARTHRITIS

Номер: KR1020160019006A
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a substance derived from Astragali Radix for preventing or treating arthritis and, more specifically, to a pharmaceutical composition comprising a substance derived from Astragali Radix having preventive or therapeutic activities for arthritis by inhibiting the activities of matrix metalloprotease (MMP)-1, MMP-2, MMP-3, MMP-9, and MMP-13, and to a health functional food composition for preventing or alleviating arthritis. COPYRIGHT KIPO 2016 ...

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26-05-2016 дата публикации

PHARMACEUTICAL COMPOSITION COMPRISING EXTRACTS OF SYMPLOCOCS CHINESIS AND ASTRAGALUS MEMBRANACEUS FOR PREVENTING AND TREATING ARTHRITIS, AND METHOD FOR PREPARING SAME

Номер: WO2016080691A1
Принадлежит:

The present invention relates to a pharmaceutical composition comprising extracts of Symplococs chinesis and Astragalus membranaceus for preventing and treating arthritis, and a method for preparing the same. More particularly, the present invention provides a pharmaceutical composition comprising, as active ingredients, extracts of Symplococs chinesis and Astragalus membranaceus for preventing or treating arthritis, and a method for preparing the composition comprising the steps of: preparing medicinal herbs including Symplococs chinesis and Astragalus membranaceus; and adding water or C1-4 alcohol to the prepared medicinal herbs to extract the same.

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17-04-2018 дата публикации

TSPYL5 단백질 120번째 트레오닌 잔기의 인산화 억제에 의한 암줄기세포 성장조절 방법과 인산화 억제기능 펩타이드 서열 함유 조성물 및 이의 용도

Номер: KR0101848803B1
Принадлежит: 한국원자력연구원

... 본 발명은 TSPYL5(Testis-specific Y-like protein 5) 단백질의 120번째 트레오닌(threonine) 잔기의 인산화를 억제하는 펩타이드에 관한 것으로, 구체적인 내용은 다음과 같다. TSPYL5의 120번째 트레오닌(T120) 잔기의 돌연변이체인 T120D 및 T120A-TSPYL5 유전자를 제작하여 T120 잔기의 인산화에 의한 영향을 확인하고자 세포에 형질전환시킨 결과, 정상형 TSPYL5와 T120D는 핵안으로도 이동하여 존재하고 있으나, T120A의 경우 TSPYL5 단백질이 핵안으로 이동하지 못하고 세포질 내에서만 발현되었고, 또한 AKT와 결합하지 못하였으며, TSPYL5 단백질의 유비퀴틴화 (ubiquitination)가 증가하고, 수모화(sumoylation)가 억제됨을 확인하였으며, ALDH1-A1, -A3, CD44 유전자 및 단백질의 발현이 감소됨을 확인하였고, 폐암 세포의 성장 및 전이가 감소하였으며, sphere 형성이 감소됨을 확인하였다. 이에 근거하여 TSPYL5의 120번째 트레오닌 잔기의 인산화를 억제하는 본 발명의 서열번호 43 또는 서열번호 44의 아미노산으로 구성된 펩타이드를 고안하였으며, 이들은 암세포의 성장 또는 전이, 또는 암 줄기세포 성장 억제제 조성물로써 유용하게 사용될 수 있다.

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26-03-2018 дата публикации

황기 추출물 및 지치 추출물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약학적 조성물

Номер: KR0101841541B1
Принадлежит: 대한민국

... 본 발명은 황기 추출물 및 지치 추출물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약학적 조성물에 관한 것으로서, 보다 상세하게는 연골기질물질 분해효소(matrix metalloprotease; MMP)-1, MMP-3, MMP-13의 활성을 저해하고 염증으로 인한 통증을 억제하여 관절염 예방 또는 치료 활성을 갖는 황기 추출물 및 지치 추출물을 유효성분으로 포함하는 관절염 예방 또는 치료용 약학적 조성물, 관절염 예방 또는 개선용 건강기능식품, 염증성 통증 완화 또는 억제용 조성물 및 염증성 통증 완화 또는 개선용 건강기능식품에 관한 것이다.

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10-05-2017 дата публикации

NOVEL COMPOUND DERIVED FROM LITHOSPERMI RADIX

Номер: KR1020170048768A
Принадлежит:

The present invention relates to a novel compound, and more specifically, to a novel compound which shows therapeutic activities on arthritis by reducing activities of matrix metalloprotease (MMP)-1, MMP-3, and MMP-13, and suppressing inflammation-induced pain; to a pharmaceutical composition comprising the novel compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating arthritis; to a pharmaceutical composition comprising the novel compound or a pharmaceutically acceptable salt thereof as an active ingredient for alleviating or suppressing inflammatory pain; to a functional health food product comprising the novel compound or a sitologically acceptable salt thereof as an active ingredient for preventing or alleviating arthritis; and a functional health food product comprising the novel compound or a sitologically acceptable salt thereof as an active ingredient for alleviating or reducing inflammatory pain. COPYRIGHT KIPO 2017 ...

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29-07-2016 дата публикации

COMPOSITION FOR INHIBITING CANCER STEM CELL GROWTH AND CANCER METASTASIS COMPRISING TSPYL5 EXPRESSION OR ACTIVATION INHIBITOR

Номер: KR1020160090274A
Принадлежит:

The present invention relates to a pharmaceutical composition for inhibiting cancer metastasis, which comprises an agent for inhibiting expression or activity of testis-specific protein, Y-encoded-like 5 (TSPYL5) as an active ingredient. After A549 cells that are non-small cell lung cancer cells are radiated with divided radiation, it is shown that expression of TSPYL5 and cancer stem cell markers, ALDH1 and CD44, is increased significantly, and that inhibition of expression or activity of TSPYL5 inhibits expression of cancer stem cell markers, ALDH1 and CD44, to reduce the EMT function which is an important pathway of cancer stem cell growth and metastasis. It is also shown that growth of malignant cells is inhibited. Therefore, a TSPYL5 expression or activity inhibitor may be useful as an active ingredient for a composition for inhibiting cancer stem cell growth and cancer metastasis in various types of tumors. COPYRIGHT KIPO 2016 ...

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27-12-2017 дата публикации

METHOD FOR REGULATING CANCER STEM CELL GROWTH BY INHIBITING PHOSPHORYLATION OF TSPYL5 PROTEIN 120^th THREONINE RESIDUE, COMPOSITION CONTAINING PHOSPHORYLATION INHIBITING FUNCTION PEPTIDE SEQUENCE, AND USE THEREOF

Номер: KR1020170141849A
Принадлежит:

The present invention relates to a peptide for inhibiting the phosphorylation of a 120^th threonine (T120) residue of testis-specific Y-like protein 5 (TSPYL5). More specifically, T120D and T120A-TSPYL5 genes, which are mutants of the T120 residue of TSPYL5, are prepared and transformed into cells to confirm influence by phosphorylation of the T120 residue. As a result, it has been confirmed that normal-type T120YL5 and T120D migrate into the nucleus, but TSPYL5 cannot migrate into the nucleus but is expressed only in the cytoplasm in T120A, and cannot bind with AKT; ubiquitination of the TSPYL5 is increased; and sumoylation is inhibited. Also, it has been confirmed that the expression of ALDH1-A1, -A3, CD44 genes and protein is reduced; the growth and metastasis of lung cancer cells are reduced; and sphere formation is reduced. On the basis thereof, a peptide consisting of the amino acid sequence of SEQ ID NO: 43 or SEQ ID NO: 44 of the present invention, which inhibits the phosphorylation ...

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24-09-2015 дата публикации

LACTOBACILLUS PLANTARUM YD-212 STRAIN, AND COMPOSITION CONTAINING FERMENTED PRODUCT PRODUCED BY USING SAME

Номер: KR101554875B1
Принадлежит: YD LIFE SCIENCE CO., LTD.

The present invention provides a Lactobacillus plantarum YD-212 strain which is isolated from feces of healthy Korean adults and a composition for preventing and improving an osseous metabolic disease or a pharmaceutical composition for treating, which contain, as an active ingredient, a fermented product using same. A fermented product according to the Lactobacillus plantarum YD-212 strain of the present invention can be very useful in improving, preventing or treating an osseous metabolic disease such as osteoporosis by promoting proliferation and differentiation of osteoblast and increasing a bone density and bone strength. COPYRIGHT KIPO 2015 (AA) Bone density(BMD, mg/cm^3) (BB) Treatment group ...

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08-11-2016 дата публикации

WET TISSUE MANUFACTURING DEVICE AND WET TISSUE MANUFACTURING METHOD

Номер: KR1020160128616A
Принадлежит:

Disclosed is a wet tissue manufacturing device. According to one embodiment, the wet tissue manufacturing device comprises: a main body; a water storage unit storing water; a tissue storing unit storing a tissue; a temporary storing unit where the tissue stored in the tissue storing unit is positioned after the tissue is discharged from the tissue storing unit; a discharge device moving the tissue from the tissue storing unit to the temporary storing unit; and a stem unit converting the water stored in the water storing unit into steam to be injected to the temporary storing unit in order to enable the tissue to be wet. COPYRIGHT KIPO 2016 ...

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17-02-2011 дата публикации

COMPOSITION FOR PREVENTING OR TREATING ARTHRITIS, CONTAINING AN EXTRACT OF AN HERBAL MEDICINE MIXTURE OF SCHISANDRA CHINENSIS BAILLON, SCUTELLARIA BAICALENSIS AND KALOPANAX PICTUS NAKAI AS AN ACTIVE INGREDIENT

Номер: KR2011019153A2
Принадлежит:

The present invention relates to a composition for preventing or treating arthritis, containing an extract of an herbal medicine mixture of Schisandra chinensis Baillon, Scutellaria baicalensis and Kalopanax pictus Nakai as an active ingredient. The extract of an herbal medicine mixture of Schisandra chinensis Baillon, Scutellaria baicalensis and Kalopanax pictus Nakai contained in the composition of the present invention inhibits the synthesis and breakdown of extracellular matrix components of chondrocytes containing hyaluronic acid in the joint of a person, which might otherwise generally occur in the joint of a patient suffering from osteoarthritis. The extract of an herbal medicine mixture contained in the composition of the present invention relieves edema and pain which are the cardinal symptoms of arthritis. Therefore, the composition of the present invention containing the extract of an herbal medicine mixture can be effectively used in preventing or treating arthritis.

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