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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 17. Отображено 17.
27-11-2017 дата публикации

BRASSIERE

Номер: KR101802085B1
Автор: CHOI, JONG HEE
Принадлежит: CHOI, JONG HEE

The present invention provides a brassiere, which enables a user to selectively wear a dual pad if necessary besides a basic pad for providing convenience according to a body shape of the user and also more effectively supporting a bust and at the same time performing correction in a state of maximally narrowing the bust inwards after being worn to maximally uplift a female bust point for enabling the user to look more voluminous and sexy. The present invention provides the brassiere (100) in which bust bands (120) are connected to both sides of a pair of brassiere cups (110) respectively where basic pads (140) made of sponge are embedded as a core and shoulder straps (130) are connected between upper parts of both side brassiere cups (110) and both side bust bands (120). A second pocket (160) is overlapped on a first pocket (150) in each of the both side brassiere cups (110), a first assistant pad (210) uplifting the bust is inserted into the first pocket (150) and a second assistant pad ...

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Номер записи: 1
13-01-2011 дата публикации

METHOD FOR PREPARING TRICYCLIC DERIVATIVES

Номер: WO2011004980A3
Автор: KIM, Myung-Hwa, YE, In-Hae, CHOI, Jong-Hee
Принадлежит:

The present invention relates to a method for preparing tricyclic derivatives, and more particularly, to a method for preparing intermediates of novel tricyclic derivatives having a superior yield rate and purity, wherein the method involves esterifying 2-fluoroisophthalic acid compounds, conducting a substation reaction on the compounds to introduce a hydroxyl group, introducing a piperidyl group, conducting a reduction reaction on the compounds, introducing a hydroxyl group, and conducting a hydrolysis on the resultant compounds. The present invention also relates to a method for preparing tricyclic derivatives using the intermediates. The method of the present invention refines substances by recrystallization as opposed to conventional methods which involve refining substances by column chromatography, and thus prepares tricyclic derivatives having more excellent productivity, economical advantages, and higher purity and yield rate as compared to conventional methods, as well as to intermediates ...

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Номер записи: 2
31-10-2018 дата публикации

COMPOSITION COMPRISING SCHISANDRA CHINENSIS SEED EXTRACT FOR PREVENTING OR TREATING NEUROLOGICAL IMMUNE DISEASES

Номер: KR1020180118346A
Автор: CHO, IK HYUN, CHOI, JONG HEE, LEE, MIN JUNG, LIM, SUNG GYU, LEE, YOUN WOO, RYU, JE BIN, KWON, DONG EUI
Принадлежит:

The present invention relates to a pharmaceutical composition and a health functional food for the prevention or treatment of neurological immune diseases comprising an extract of Schisandra chinensis seed as an active ingredient. The Schisandra chinensis seed extract of the present invention ameliorates the neurological clinical sign scale of the neurological autoimmune disease and inhibits dehydration of the spinal cord. COPYRIGHT KIPO 2018 ...

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Номер записи: 3
24-05-2018 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF TEMPORAL LOBE EPILEPSY COMPRISING EXTRACT OF VALERIANA FAURIEI AS ACTIVE INGREDIENT

Номер: KR1020180054381A
Автор: CHO, IK HYUN, CHOI, JONG HEE, KIM, YOUNG OCK, PARK, CHUN GEON, LEE, SANG WON, KIM, YEON BOK, LEE, SANG HYUN, KIM, HAK JAE
Принадлежит:

The present invention relates to a pharmaceutical composition for the prevention or treatment of temporal lobe epilepsy comprising an extract of Valeriana fauriei as an active ingredient, which can effectively prevent, treat, or alleviate temporal lobe epilepsy. The present invention additionally relates to health functional food for the prevention or treatment of temporal lobe epilepsy. COPYRIGHT KIPO 2018 ...

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Номер записи: 4
23-05-2018 дата публикации

오미자 줄기 추출물을 함유하는 신경계 질환의 예방 또는 치료용 조성물

Номер: KR0101860401B1
Автор: 조익현, 김은정, 최종희, 임성규
Принадлежит: 경희대학교 산학협력단

... 본 발명은 오미자 줄기 추출물을 포함하는 신경계 질환의 예방 또는 치료용 약학적 조성물 및 건강기능식품에 관한 것이다. 본 발명의 오미자 줄기 추출물은 신경세포 사멸을 억제하고, 숙신산 탈수소 효소의 활성을 증가시키며, 미세아교세포의 활성을 억제하며, 도파민성 신경세포를 증가시키며, 염증에 의한 신경손상 회복 효과를 보이는 등 뇌신경세포 보호 효과가 뛰어나므로 신경계 질환의 예방 또는 치료용 약학적 조성물 내지 건강기능식품으로 유용하게 이용할 수 있다.

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Номер записи: 5
09-03-2017 дата публикации

복합 생약 추출물을 유효성분으로 함유하는 신경계 자가면역질환 예방 및 치료용 약학적 조성물

Номер: KR0101713822B1
Автор: 조익현, 최종희
Принадлежит: 경희대학교 산학협력단

... 본 발명은 혼합추출물을 유효성분으로 함유하는 신경계 자가면역질환 예방 및 치료용 약학적 조성물에 관한 것으로, 본 발명의 강활(ostericum koreanum), 독활(aralia cordata), 시호(bupleurum falcatum), 전호(anthriscus sylvestris), 형개(schizonepeta rhizome), 방풍(saposhnikovia), 적복령(poria cocos), 생지황(rehmannia glutinosa), 지골피(lycium chinense) 및 차전자(plantago asiatica)의 혼합추출물을 유효성분으로 함유하는 조성물은 MOG(myelin oligodendrocyte glycoprotein) 펩타이드에 의해 유도된 자가면역성 뇌척수염(EAE, experimental autoimmune encephalomyelitis) 동물모델에서 질병의 신경학적인 임상증상 척도를 개선하고, EAE에 의해 증가된 말초혈액 내의 백혈구의 수를 감소시키고, 척수의 탈수초화, 염증세포의 침윤, 미세아교세포의 활성화 및 침윤을 감소시키며, 전염증성 사이토카인, iNOS 및 백혈구와 관련한 케모카인의 발현과 MAPKs 및 NF-κB의 신호기전 및 비장 세포의 증식을 억제하고, 혈액뇌장벽을 안정화시키면서 세포독성은 나타내지 않으면서, 강활 및 방풍 혼합추출물이나 시호 단독추출물에 비해 질병의 신경학적인 임상증상 척도를 더 효과적으로 개선하므로, 상기 혼합추출물은 신경계 자가면역질환 예방 및 치료를 위한 조성물로 유용하게 사용될 수 있다.

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Номер записи: 6
29-12-2011 дата публикации

PHARMACEUTICAL COMPOSITION IN WHICH SOLUBILITY OF PARTIALLY SOLUBLE TRICYCLIC DERIVATIVE IS IMPROVED

Номер: WO2011162560A3
Автор: KIM, Myung-Hwa, CHUN, Kwang-Woo, YE, In-Hae, CHOI, Jong-Hee
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a phospholipid, cholesterol, an ionic lipid, and nanoparticles comprising a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. According to the present invention, it is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.

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Номер записи: 7
08-02-2018 дата публикации

트리사이클로 유도체 화합물의 신규한 결정형 산부가염 또는 이의 수화물 및 이의 제조방법

Номер: KR0101827444B1
Автор: 김명화, 예인해, 박준호, 최종희, 강동일
Принадлежит: 제일약품주식회사

... 본 발명은 트리사이클로 유도체 화합물의 신규한 결정형 산부가염 또는 이의 수화물 및 이의 제조방법에 관한 것이다. 본 발명에 의한 결정형 산부가염 또는 이의 수화물의 경우, 수분에 대하여 안정함에 따라 인습에 대하여 안정하므로 약물 제조시, 품질을 유지하는데 매우 유용하고, 뿐만 아니라, PARP(폴리(ADP-리보오스)폴리머라제) 과잉활성에 의해 유발되는 질환인 신경병리성 동통, 간질, 뇌졸중, 알츠하이머병, 파킨슨병, 근위축성 축삭 경화증(ALS), 헌팅톤병, 정신분열병, 만성 및 급성 통증, 허혈성 뇌손상, 저산소증 후의 신경세포 손실, 외상 및 신경 손상의 치료용 약학적 조성물로 유용하게 사용될 수 있다.

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Номер записи: 8
15-10-2015 дата публикации

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES IN NERVOUS SYSTEM COMPRISING COMPOSITE HERBAL EXTRACT AS ACTIVE INGREDIENT

Номер: KR1020150116404A
Автор: CHO, IK HYUN, CHOI, JONG HEE
Принадлежит:

The present invention relates to a composition for preventing and treating autoimmune disease in nervous system comprising mixed extracts as active ingredients and the composition can be helpfully used for preventing and treating autoimmune disease in nervous system comprising mixed extracts of Ostericum koreanum, Aralia cordata, Bupleurum falcatum, Anthriscus sylvestris, Schizonepeta rhizome, Saposhnikovia, Poria cocos, Rehmannia glutinosa, Lycium chinense and Plantago asiatica as active ingredients. COPYRIGHT KIPO 2016 (AA, BB) EAE + Extract(30% ethanol, 15mg/kg, n=6) (CC) Sum of clinical symptom levels after EAE induction until 8-30 days (DD) Extract 15 ...

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Номер записи: 9
13-01-2011 дата публикации

METHOD FOR PREPARING TRICYCLIC DERIVATIVES

Номер: KR2011004980A2
Автор: KIM, Myung-Hwa, YE, In-Hae, CHOI, Jong-Hee
Принадлежит:

The present invention relates to a method for preparing tricyclic derivatives, and more particularly, to a method for preparing intermediates of novel tricyclic derivatives having a superior yield rate and purity, wherein the method involves esterifying 2-fluoroisophthalic acid compounds, conducting a substation reaction on the compounds to introduce a hydroxyl group, introducing a piperidyl group, conducting a reduction reaction on the compounds, introducing a hydroxyl group, and conducting a hydrolysis on the resultant compounds. The present invention also relates to a method for preparing tricyclic derivatives using the intermediates. The method of the present invention refines substances by recrystallization as opposed to conventional methods which involve refining substances by column chromatography, and thus prepares tricyclic derivatives having more excellent productivity, economical advantages, and higher purity and yield rate as compared to conventional methods, as well as to intermediates ...

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Номер записи: 10
15-02-2017 дата публикации

COMPOSITION COMPRISING STEM EXTRACT OF SCHISANDRA CHINENSIS FOR PREVENTING OR TREATING NEUROLOGICAL DISEASE

Номер: KR1020170017388A
Автор: CHO, IK HYUN, KIM, EUN JEONG, CHOI, JONG HEE, LIM, SUNG GYU
Принадлежит:

The present invention relates to a pharmaceutical composition and a health functional food comprising a stem extract of Schisandra chinensis for preventing and treating neurological diseases. The stem extract of Schisandra chinensis inhibits death of neuron, improves activity of succinic dehydrogenase, inhibits activity of microglia, increases dopaminergic neuron, and shows recovery effects of neural damage caused by inflammation, thereby having protective effects of brain nerve cells and being used as a pharmaceutical composition and a health functional food for preventing and treating neurological diseases. COPYRIGHT KIPO 2017 ...

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Номер записи: 11
08-11-2018 дата публикации

오미자 씨앗 추출물을 함유하는 신경계 면역학적 질환의 예방 또는 치료용 조성물

Номер: KR0101916945B1
Автор: 조익현, 최종희, 이민정, 임성규, 이윤우, 류제빈, 권동의
Принадлежит: 경희대학교 산학협력단, 서울대학교산학협력단

... 본 발명은 오미자 씨앗 추출물을 유효성분으로 포함하는 신경계 면역 질환의 예방 또는 치료용 약학적 조성물 및 건강기능식품에 관한 것이다.

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Номер записи: 12
29-12-2011 дата публикации

PHARMACEUTICAL COMPOSITION IN WHICH SOLUBILITY OF PARTIALLY SOLUBLE TRICYCLIC DERIVATIVE IS IMPROVED

Номер: WO2011162560A2
Автор: KIM, Myung-Hwa, CHUN, Kwang-Woo, YE, In-Hae, CHOI, Jong-Hee
Принадлежит:

The present invention relates to a pharmaceutical composition comprising a phospholipid, cholesterol, an ionic lipid, and nanoparticles comprising a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. According to the present invention, it is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.

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Номер записи: 13
20-05-2010 дата публикации

NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Номер: WO2010056038A2
Автор: KIM, Myung-Hwa, KIM, Seung-Hyun, KU, Sae-Kwang, PARK, Chun-Ho, JOE, Bo-Young, CHUN, Kwang-Woo, YE, In-Hae, CHOI, Jong-Hee, RYU, Dong-Kyu, PARK, Ji-Seon, LEE, Han-Chang, CHOI, Ji-So, KIM, Young-Chul
Принадлежит:

The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.

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Номер записи: 14
22-12-2016 дата публикации

COMPOSITION CONTAINING SCHISANDRA CHINENSIS LEAF EXTRACT FOR PREVENTING OR TREATING PARKISON′S DISEASE OR NEURODEGENERATIVE DISEASES

Номер: KR1020160147132A
Автор: CHO, IK HYUN, KIM, EUN JEONG, CHOI, JONG HEE
Принадлежит:

The present invention relates to a pharmaceutical composition and a functional health food containing Schisandra chinensis leaves for preventing or treating stroke, Parkison′s disease, and/or neurodegenerative diseases. A Schisandra chinensis leaf extract of the present invention reduces neuroinflammation, suppresses activation of microglial cells and effectively protects neuronal cells, thereby being used as a pharmaceutical composition or a functional health food for preventing or treating stroke, Parkison′s disease, and/or neurodegenerative diseases. COPYRIGHT KIPO 2017 ...

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Номер записи: 15
20-05-2010 дата публикации

NOVEL TRICYCLIC DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Номер: WO2010056038A3
Автор: KIM, Myung-Hwa, KIM, Seung-Hyun, KU, Sae-Kwang, PARK, Chun-Ho, JOE, Bo-Young, CHUN, Kwang-Woo, YE, In-Hae, CHOI, Jong-Hee, RYU, Dong-Kyu, PARK, Ji-Seon, LEE, Han-Chang, CHOI, Ji-So, KIM, Young-Chul
Принадлежит:

The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.

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Номер записи: 16
08-08-2013 дата публикации

NOVEL CRYSTALLINE ACID ADDITION SALT OF TRICYCLO DERIVATIVE COMPOUND OR HYDRIDE THEREOF, AND PRODUCTION METHOD THEREFOR

Номер: WO2013115535A1
Автор: YE, In-Hae, PARK, Chun-Ho, CHOI, Jong-Hee, KANG, Dong-il
Принадлежит:

The present invention relates to a novel crystalline acid addition salt of a tricyclo derivative compound or a hydride thereof, and to a production method therefor. The crystalline acid addition salt or the hydride thereof according to the present invention is stable with respect to moisture and consequently stable with respect to hygroscopicity and so is very useful in maintaining quality when producing a drug, and, in addition, can be used to advantage as a pharmaceutical composition for treating neuropathic pain, epilepsy, stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), Huntington's disease, schizophrenia, chronic and acute pain, ischemic brain injury, neuronal loss after hypoxia, trauma and nerve damage, which are medical conditions induced by PARP (poly (ADP-ribose) polymerase) overactivity.

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Номер записи: 17