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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 22. Отображено 22.
23-08-2018 дата публикации

NOVEL BENZIMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF

Номер: WO2018151562A2
Автор: HAH, Jung Mi, YANG, Song I
Принадлежит:

The present invention relates to a novel benzimidazole derivative having C-Jun N-terminal kinase (JNK) inhibitory activity and a use thereof. The novel benzimidazole derivative according to the present invention or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activity against c-Jun N-terminal kinase 3 (JNK 3), and thus it is expected that target therapy can be attained through a more fundamental approach in the prevention or treatment of degenerative brain-nerve system diseases.

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Номер записи: 1
01-09-2016 дата публикации

THIENODIAZEPINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Номер: WO2016137060A1
Автор: HAH, Jung-Mi, LEE, Jung Hun, KIM, Minjung
Принадлежит:

The present invention relates to: a novel thienodiazepine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the same. The thienodiazepine derivative or the pharmaceutically acceptable salt thereof, according to the present invention, exhibits selective inhibitory activity against protein kinases such as c-Kit, FLT3, FMS, LYN, RAF1, VEGFR3, PDGFRa, PDGFRb, RET, or the like, and thus can be used as a pharmaceutical composition for preventing or treating abnormal cell growth disorders.

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Номер записи: 2
05-09-2018 дата публикации

JNK 저해 활성을 갖는 신규한 이미다졸 유도체 및 이의 용도

Номер: KR0101894096B1
Автор: 하정미, 양송이, 이정헌
Принадлежит: 삼진제약주식회사

... 본 발명은 JNK (C-Jun N-terminal kinase) 저해 활성을 갖는 신규한 이미다졸 유도체 및 이의 용도에 관한 것이다. 본 발명에 따른 신규 이미다졸 유도체 또는 이의 약학적으로 허용가능한 염은 JNK (c-Jun N-terminal kinase)에 대한 우수한 저해 활성을 나타내는바, 퇴행성 뇌신경계 질환의 예방 또는 치료에 있어서, 보다 근본적으로 접근하여 타겟 치료할 수 있을 것으로 기대된다.

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Номер записи: 3
29-03-2023 дата публикации

단백질 인산화 효소 저해 활성을 갖는 신규한 피라졸 유도체 및 이의 용도

Номер: KR1025142450000B1
Автор: 하정미, 오유리
Принадлежит: 한양대학교 에리카산학협력단

... 본 발명은 신규 피라졸 유도체 화합물, 이의 이성질체 또는 이의 약학적으로 허용 가능한 염 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 피라졸 유도체 화합물은 JNK, 특히 JNK3에 대해 선택적으로 저해 활성을 나타내어 신경계 질환 (알츠하이머성 치매성 치매, 파킨슨 질환을 포함하는 퇴행성 뇌질환)의 예방 및 치료용 약학적 조성물로 이용될 수 있다.

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Номер записи: 4
13-12-2018 дата публикации

NOVEL BENZIMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF

Номер: WO2018151562A3
Автор: HAH, Jung Mi, YANG, Song I
Принадлежит:

The present invention relates to a novel benzimidazole derivative having C-Jun N-terminal kinase (JNK) inhibitory activity and a use thereof. The novel benzimidazole derivative according to the present invention or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activity against c-Jun N-terminal kinase 3 (JNK 3), and thus it is expected that target therapy can be attained through a more fundamental approach in the prevention or treatment of degenerative brain-nerve system diseases.

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Номер записи: 5
11-05-2017 дата публикации

COLOR NANOCOMPOSITE AND MANUFACTURING METHOD THEREOF

Номер: KR1020170051293A
Автор: KIM, CHUL AM, RYU, JI YOUNG, KIM, HA YOUNG, HA, JEONG MI, JOO, JAE HYUN
Принадлежит:

The present invention relates to a color nanocomposite rearranged by an electric field or a magnetic field and including a nanoparticle, and a manufacturing method thereof. The color nanocomposite has a color difference (ΔE*ab) before and after applying an electric field or a magnetic field according to color coordinates of a CIE system of color specification is 2.2 or more, and the full width at half maximum (FWHM) of a particle size distribution curve is 10 nm or less, wherein a zeta potential value in a water-dispersed state of the color nanocomposite is four times or more different from a zeta potential value of a water-dispersed state of a nanoparticle. COPYRIGHT KIPO 2017 (A1,A2,A3,A4) Nanocomposite (B1,B2,B3,B4) Colloid particle (C1,C2,C3,C4) Dye or pigment (D1,D2) Curing material (E1,E2) Expressing material ...

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Номер записи: 6
31-08-2016 дата публикации

THIENODIAZEPINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT

Номер: KR1020160102821A
Автор: HAH, JUNG MI, LEE, JUNG HUN, KIM, MIN JUNG
Принадлежит:

The present invention relates to a novel thienodiazepine derivative, pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. According to the present invention, the thienodiazepine derivative or pharmaceutically acceptable salt thereof exhibits inhibitory activity selective to protein kinase such as c-Kit, FLT3, FMS, LYN, RAF1, VEGFR3, PDGFRa, PDGFRb, RET, and the like. Thus, the thienodiazepine derivative or pharmaceutically acceptable salt thereof can be used as a pharmaceutical composition for preventing or treating abnormal cell growth diseases. COPYRIGHT KIPO 2016 ...

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Номер записи: 7
31-03-2016 дата публикации

N-(5-ARYLAMIDO-2-METHYLPHENYL)-5-METHYLISOXAZOLE-4-CARBOXAMIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING SAME, AND FMS KINASE INHIBITOR INCLUDING SAME AS EFFECTIVE INGREDIENT

Номер: WO2016047967A2
Автор: HAH, Jung-Mi, JUNG, Kyung Jin
Принадлежит:

The present invention relates to an N-(5-arylamido-2-methylphenyl)-5-methylisoxazole-4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including same. A compound according to the present invention exhibits an FMS kinase inhibitory activity and can thus be used as a pharmaceutical composition for preventing or treating diseases related thereto.

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Номер записи: 8
23-08-2018 дата публикации

NOVEL BENZIMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF

Номер: WO2018151562A9
Автор: HAH, Jung Mi, YANG, Song I
Принадлежит:

The present invention relates to a novel benzimidazole derivative having C-Jun N-terminal kinase (JNK) inhibitory activity and a use thereof. The novel benzimidazole derivative according to the present invention or a pharmaceutically acceptable salt thereof exhibits excellent inhibitory activity against c-Jun N-terminal kinase 3 (JNK 3), and thus it is expected that target therapy can be attained through a more fundamental approach in the prevention or treatment of degenerative brain-nerve system diseases.

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Номер записи: 9
09-08-2017 дата публикации

NOVEL IMIDAZOLE DERIVATIVES HAVING JNK-INHIBITORY ACTIVITY AND USES THEREOF

Номер: KR1020170091516A
Автор: HAH, JUNG MI, YANG, SONG I, LEE, JUNG HUN
Принадлежит:

The present invention relates to novel imidazole derivatives having C-Jun N-terminal kinase (JNK)-inhibitory activity and uses thereof. The novel imidazole derivatives or pharmaceutically allowable salts thereof according to the present invention show excellent JNK-inhibitory activity, thereby preventing or treating degenerative brain-nervous system diseases. Accordingly, it is expected to perform target treatment. COPYRIGHT KIPO 2017 ...

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Номер записи: 10
04-05-2017 дата публикации

MICROPARTICLES CONTAINING COLOR NANOCOMPOSITE AND METHOD FOR MANUFACTURING SAME

Номер: WO2017074152A1
Автор: KIM, Chul Am, RYU, Ji Young, KIM, Ha Young, HA, Jeong Mi, JOO, Jae Hyun, LEE, In Sook, OH, Jin Ho, CHA, Jin Sung
Принадлежит:

The present invention relates to microparticles which are rearranged by the application of an electric field or a magnetic field and contain a color nanocomposite including nanoparticles, and to a method for manufacturing the microparticles, wherein, in the microparticles, the pencil hardness in a dry powder state is 4B or less; and the pore volume of the region of 5 nm or less is 20% or less of the total pore volume in the pore size distribution according to the specific surface area measurement using nitrogen gas, and the pore volume of the region of 3 nm or less is 20% or less of the total pore volume in the pore distribution according to the specific surface area measurement using argon gas.

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Номер записи: 11
18-07-2016 дата публикации

IMIDAZOLE-1-YL PYRIMIDINE DERIVATIVES, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT

Номер: KR1020160085650A
Автор: HAH, JUNG MI
Принадлежит:

The present invention relates to novel imidazole-1-yl pyrimidine derivatives, or to a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising the same. According to the present invention, the imidazole-1-yl pyrimidine derivatives exhibit inhibitory activities with respect to BRAF, a mutant of BRAF, or CRAF in a selective manner, and can be used as a pharmaceutical composition for preventing or treating cancer. COPYRIGHT KIPO 2016 ...

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Номер записи: 12
05-08-2016 дата публикации

N-(5-아릴아미도-2-메틸페닐)-5-메틸이소옥사졸-4-카복스아미드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 FMS 키나아제 저해제

Номер: KR0101646180B1
Автор: 하정미, 정경진
Принадлежит: 한양대학교 에리카산학협력단

... 본 발명은 하기 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 화합물은 FMS 키나아제 저해 활성을 나타내어 이와 관련된 질환의 예방 또는 치료용 약학적 조성물로 사용될 수 있다. [화학식 1] 상기 식에서, R1 및 R2의 정의는 명세서에 정의된 바와 같다.

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Номер записи: 13
21-03-2018 дата публикации

NOVEL BENZIMIDAZOLE DERIVATES HAVING JNK-INHIBITORY ACTIVITIES AND USE THEREOF

Номер: KR101840674B1
Автор: HAH, JUNG MI, YANG, SONG I
Принадлежит: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY ERICA CAMPUS

The present invention relates to novel benzimidazole derivatives having C-Jun N-terminal kinase (JNK)-inhibitory activities, and relates to a use thereof. According to the present invention, novel benzimidazole derivatives or pharmaceutically acceptable slats thereof exhibit the excellent inhibitory activities in accordance with c-Jun N-terminal kinase 3 (JNK 3), and are expected to treat the target by approaching the prevention or the treatment of degenerative brain diseases in a fundamental manner. COPYRIGHT KIPO 2018 ...

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Номер записи: 14
20-06-2018 дата публикации

SMOKING BOOTH WITH HEAT EXCHANGING VENTILATION SYSTEM

Номер: KR1020180067271A
Автор: HA, JEONG MI
Принадлежит:

The present invention relates to a smoking booth of a ventilation system, which comprises: a smoking booth (1) having a space part (20) formed on the upper part of a ceiling (11) of a smoking room (10), an air chamber (13) formed on the lower part of a bottom (12), and a pipe room (30) formed on one side of the smoking room (10); an ash tray (40); a suction unit (50); a heat exchanger (60); an exhaust pipe (71); and a suction pipe (72). A heat loss can be minimized to obtain a significant energy saving effect. COPYRIGHT KIPO 2018 ...

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Номер записи: 15
14-11-2016 дата публикации

티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물

Номер: KR0101675984B1
Автор: 하정미, 이정헌, 김민정
Принадлежит: 한양대학교 에리카산학협력단

... 본 발명은 신규한 티에노디아제핀 유도체, 이의 약학적으로 허용가능한 염, 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 티에노디아제핀 유도체 또는 이의 약학적으로 허용가능한 염은 c-Kit, FLT3, FMS, LYN, RAF1, VEGFR3, PDGFRa, PDGFRb, RET 등과 같은 단백질 키나아제에 대해 선택적인 저해 활성을 나타내어 비정상 세포 성장 질환의 예방 또는 치료용 약학적 조성물로 이용될 수 있다.

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Номер записи: 16
30-01-2020 дата публикации

NOVEL IMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Номер: WO2020022787A1
Автор: SHIN, Hee Jong, KI, Min Hyo, KWON, Ho Seok, LEE, Jae Woong, AHN, So Yeon, KIM, Yu Ro, LEE, Jong Hwan, HAH, Jung Mi, MOON, Hyung Woo, KIM, Jin Woong
Принадлежит:

The present invention relates to a novel imidazole derivative having JNK inhibitory activity, or a pharmaceutically acceptable salt, optical isomer, hydrate, or solvate thereof, and a pharmaceutical composition comprising same, the imidazole derivative being a compound having the structure of chemical formula 1. [Chemical Formula 1] ...

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Номер записи: 17
23-07-2018 дата публикации

컬러 나노 복합체 및 이의 제조방법

Номер: KR0101880908B1
Автор: 김철암, 류지영, 김하영, 하정미, 주재현
Принадлежит: (주)나노브릭

... 본 발명은 전기장 또는 자기장의 인가에 의하여 재배열되며 나노입자를 포함하는 컬러 나노 복합체 및 이의 제조방법에 관한 것으로서, 상기 컬러 나노 복합체는 CIE 표색계의 색좌표에 따른 전기장 또는 자기장의 인가 전후의 색차(ΔE*ab)가 2.2 이상이며, 입도분포곡선의 반치폭(full width at half maximum, FWHM)이 10nm 이하이며, 상기 컬러 나노 복합체의 수분산 상태의 제타전위 값이 상기 나노입자의 수분산 상태의 제타전위 값과 비교하여 4배 이상 차이가 나는 것을 특징으로 한다.

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Номер записи: 18
24-10-2016 дата публикации

이미다졸-1-일 피리미딘 유도체, 또는 이의 약학적으로 허용가능한 염 및 이를 유효성분으로 포함하는 약학적 조성물

Номер: KR0101668857B1
Автор: 하정미
Принадлежит: 한양대학교 에리카산학협력단

... 본 발명은 신규한 이미다졸-1-일 피리미딘 유도체, 이의 약학적으로 허용가능한 염, 및 이를 포함하는 약학적 조성물에 관한 것이다. 본 발명에 따른 이미다졸-1-일 피리미딘 유도체는 BRAF, BRAF의 돌연변이체, 또는 CRAF에 대해 선택적으로 저해 활성을 나타내어 암의 예방 또는 치료용 약학적 조성물로 이용될 수 있다.

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Номер записи: 19
03-08-2017 дата публикации

NOVEL IMIDAZOLE DERIVATIVE HAVING JNK INHIBITORY ACTIVITY AND USE THEREOF

Номер: WO2017131425A1
Автор: HAH, Jung-Mi, YANG, Song I, LEE, Jung Hun
Принадлежит:

The present invention relates to a novel imidazole derivative having a C-Jun N-terminal kinase (JNK) inhibitory activity and a use thereof. A novel imidazole derivative or a pharmaceutically acceptable salt thereof according to the present invention exhibits an excellent inhibitory activity against C-Jun N-terminal kinase (JNK), and thus it is anticipated that a more fundamental approach and target treatment will be possible in the prevention or treatment of degenerative brain nervous system diseases.

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Номер записи: 20
31-03-2016 дата публикации

N-(5-ARYLAMIDO-2-METHYLPHENYL)-5-METHYLISOXAZOLE-4-CARBOXAMIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARING SAME, AND FMS KINASE INHIBITOR INCLUDING SAME AS EFFECTIVE INGREDIENT

Номер: WO2016047967A3
Автор: HAH, Jung-Mi, JUNG, Kyung Jin
Принадлежит:

The present invention relates to an N-(5-arylamido-2-methylphenyl)-5-methylisoxazole-4-carboxamide derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including same. A compound according to the present invention exhibits an FMS kinase inhibitory activity and can thus be used as a pharmaceutical composition for preventing or treating diseases related thereto.

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Номер записи: 21
30-03-2016 дата публикации

N-(5-ARYLAMIDO-2-METHYLPHENYL)-5-METHYLISOXAZOLE-4-CARBOXAMIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCING METHOD THEREOF, AND FMS KINASE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT

Номер: KR1020160034632A
Автор: HAH, JUNG MI, JUNG, KYUNG JIN
Принадлежит:

The present invention relates to a compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. The compound according to the present invention exhibits FMS kinase inhibitory activity, and thus can be used as a pharmaceutical composition for preventing or treating diseases related FMS kinase activity. In the chemical formula 1, the definition of R1 and R2 is the same as defined in the specification. COPYRIGHT KIPO 2016 ...

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Номер записи: 22