STANDS TO ZELLTRANSPLANTATION

CONTINUOUS CELL PROGRAMMING DEVICES

The present invention comprises compositions, methods, and devices for creating an infection--mimicking environment within a polymer scaffold to stimulate antigen--specific dendritic cell activation. De-vices of the present invention are used to provide protective immunity to subjects against infection and can-cer.

CONTINUOUS CELL PROGRAMMING DEVICES

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

Continuous cell programming devices

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

Scaffolds for Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 16532655_1 (GHMatters) P77900.AU.4 t=100% I L ccI LuII t~ =0 'm AUTO-AMPUTATION IE ~NECROTIC FOOT 60%' MULTIPLE NECROTICTOES m1 240%I I ONE NECROTICTOE 40 I TIPSOF TOES (BLACK) IL II o NORMAL O ~ ~ ~ ~ 6 1 2 4 61 24 1 2 4 61 2 4 6124 TIME (eeks) SCAFFOLD;SCAFFOLD iSCAFFOLDi BOLUS BLANK EPC+OEC 1EPC OEC EPC+OEC SCAFFOLD Fig. 13D ...

Continuous cell programming devices

STORING LOGICAL UNITS OF PROGRAM CODE GENERATED USING A DYNAMIC PROGRAMMING NOTEBOOK USER INTERFACE

The programming notebook system, methods, and user interfaces described herein provide software developers with enhanced tools by which a programming notebook workflow and session history associated with code cells in a programming notebook may be tracked and maintained. As a developer progresses through a development workflow, the developer can select an option to save a program code card representing some or all of the program code cell inputs. A card editor user interface may present an aggregated listing of all program code the developer has provided across multiple code cells during the current session which the developer can edit, refine, and/or comment. The card editor may also allow the developer to add associated user interface code to display a UI component associated with the program code card, and allow the developer to add a description and tags for the card so that the card can be searched for and reused. 1. (canceled)2. A computer-implemented method of generating displayable data visualizations , the computer-implemented method comprising: analyzing at least some data items of a set of data items to determine at least a first data type associated with at least one of the data items of the set of data items, wherein the first data type comprises geographic data;', 'selecting, based at least in part on the first data type, a first visualization type from a plurality of data visualization types, wherein the plurality of data visualization types are built-in and include at least one of: time series, calendar, scatter plot, line plot, histogram, chart, graph, table, map, heat map, or geographic map, and wherein the first visualization type comprises at least one of: map, heat map, or geographic map;', 'generating at least a first displayable data visualization of the first visualization type, wherein the first displayable data visualization is based at least in part on a portion of the set of data items; and', 'causing display of the first displayable data ...

Low Power Measurements Mode

This disclosure relates to techniques for selecting a low power measurement mode (LPM mode). A wireless device may enter an idle mode, determine that it is stationary, and enter an LPM mode. In the LPM mode, the wireless device may perform cell measurements at a reduced frequency.

STORING LOGICAL UNITS OF PROGRAM CODE GENERATED USING A DYNAMIC PROGRAMMING NOTEBOOK USER INTERFACE

The programming notebook system, methods, and user interfaces described herein provide software developers with enhanced tools by which a programming notebook workflow and session history associated with code cells in a programming notebook may be tracked and maintained. As a developer progresses through a development workflow, the developer can select an option to save a program code card representing some or all of the program code cell inputs. A card editor user interface may present an aggregated listing of all program code the developer has provided across multiple code cells during the current session which the developer can edit, refine, and/or comment. The card editor may also allow the developer to add associated user interface code to display a UI component associated with the program code card, and allow the developer to add a description and tags for the card so that the card can be searched for and reused. 1. A computer system configured to generate displayable data visualizations , the computer system comprising: analyze at least some data items of a set of data items to determine one or more attributes of the set of data items;', 'select, based at least in part on the one or more attributes of the set of data items, a first one or more data visualization types of a plurality of data visualization types, wherein the plurality of data visualization types are built-in and include at least one of: time series, scatter plot, histogram, chart, graph, table, map, heat map, or geographic map;', 'generate a first plurality of displayable data visualizations based at least in part on a portion of the set of data items and at least some of the first one or more data visualization types; and', at least a first displayable data visualization of the first plurality of displayable data visualizations is interactive and is further is selectable to cause display of an enlarged version of the first displayable data visualization that is also interactive, and', 'at ...

WIRELESS DEVICE SIM ACTIVATION WHILE ROAMING

Activation or update of a subscriber identity module (SIM) via a roaming cellular wireless network by a mobile device includes the mobile device: determining a country of origin associated with a mobile network operator (MNO) for the SIM, determining a current geographic location of the mobile device, and when the current geographic location of the mobile device does not correspond to the country of origin for the MNO associated with the SIM of the eUICC, presenting an option to activate or update the SIM over a local roaming cellular wireless network. When the option is accepted, the mobile device enables a cellular data roaming capability for the mobile device, activates or updates the SIM via the local roaming cellular wireless network, and, after the SIM is activated or updated, disables the cellular data roaming capability for the mobile device.

Continuous Cell Programming Devices

The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

Low Power Measurements Mode

This disclosure relates to techniques for selecting a low power measurement mode (LPM mode). A wireless device may enter an idle mode, determine that it is stationary, and enter an LPM mode. In the LPM mode, the wireless device may perform cell measurements at a reduced frequency. 1. A method for a wireless user equipment (UE) device , the method comprising:entering an idle mode, wherein the UE performs cell measurements at a first rate while in the idle mode;determining that the UE has been stationary for a first amount of time; andentering a low power measurements mode (LPM mode) based at least in part on determining that the UE has been stationary for the first amount of time, wherein the UE performs cell measurements at a second rate, wherein the second rate is smaller than the first rate, while in the LPM mode.2. The method of claim 1 , further comprising:determining that the UE has remained in a charging state for a second amount of time; andwherein entering the LPM mode is further based at least in part on determining that the UE has been in the charging state for the second amount of time.3. The method of claim 1 , further comprising:determining that the UE is no longer stationary; andexiting the LPM mode based on determining that the UE is no longer stationary.4. The method of claim 1 , further comprising:performing a signal strength measurement of a first cell; andwherein entering the LPM mode is further based at least in part on the signal strength measurement of the first cell exceeding a first signal strength threshold.5. The method of claim 1 , further comprising:determining that the UE has remained synchronized with a first cell for at least a first number of subframes; andwherein entering the LPM mode is further based at least in part on determining that the UE has remained synchronized with the first cell for at least the first number of subframes.6. The method of claim 1 , further comprising:determining a location of the UE;determining a present ...

Storing logical units of program code generated using a dynamic programming notebook user interface

The programming notebook system, methods, and user interfaces described herein provide software developers with enhanced tools by which a programming notebook workflow and session history associated with code cells in a programming notebook may be tracked and maintained. As a developer progresses through a development workflow, the developer can select an option to save a program code card representing some or all of the program code cell inputs. A card editor user interface may present an aggregated listing of all program code the developer has provided across multiple code cells during the current session which the developer can edit, refine, and/or comment. The card editor may also allow the developer to add associated user interface code to display a UI component associated with the program code card, and allow the developer to add a description and tags for the card so that the card can be searched for and reused.

Storing logical units of program code generated using a dynamic programming notebook user interface

The programming notebook system, methods, and user interfaces described herein provide software developers with enhanced tools by which a programming notebook workflow and session history associated with code cells in a programming notebook may be tracked and maintained. As a developer progresses through a development workflow, the developer can select an option to save a program code card representing some or all of the program code cell inputs. A card editor user interface may present an aggregated listing of all program code the developer has provided across multiple code cells during the current session which the developer can edit, refine, and/or comment. The card editor may also allow the developer to add associated user interface code to display a UI component associated with the program code card, and allow the developer to add a description and tags for the card so that the card can be searched for and reused.

Low power measurements mode

This disclosure relates to techniques for selecting a low power measurement mode (LPM mode). A wireless device may enter an idle mode, determine that it is stationary, and enter an LPM mode. In the LPM mode, the wireless device may perform cell measurements at a reduced frequency.

Continuous cell programming devices

The present invention comprises compositions, methods and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

Cellular blacklisting techniques

Techniques are disclosed relating to a mobile device blacklisting certain wireless cells. The device may refrain from considering blacklisted cells for cell operations such as reselection and handover. The device may blacklist cells that fail selection criteria or system information decoding. In some embodiments, the device is configured to manage inclusion of cells on the blacklist based on whether the cells are part of a home network (e.g., an HPLMN) for the mobile device. The device may delete cells that are part of the home network from the blacklist after an out-of-service event or may refrain from adding cells from the home network to the blacklist after certain failures, for example. In various embodiments the disclosed techniques may avoid blacklisting desirable cells in certain scenarios while still enabling blacklist functionality. This may improve wireless performance and battery life, for example.

Combined control lines for device cooling fans

Described is a technology by which two or more air moving devices have some of their control lines combined, including a frequency control line from a controller. Along with the combined frequency control line, power voltage lines and ground lines and may be combined, with a separate sensing line for each air moving device. One or more couplers couples the combined lines to air moving device control circuitry.

Wireless device SIM activation while roaming

Activation or update of a subscriber identity module (SIM) via a roaming cellular wireless network by a mobile device includes the mobile device: determining a country of origin associated with a mobile network operator (MNO) for the SIM, determining a current geographic location of the mobile device, and when the current geographic location of the mobile device does not correspond to the country of origin for the MNO associated with the SIM of the eUICC, presenting an option to activate or update the SIM over a local roaming cellular wireless network. When the option is accepted, the mobile device enables a cellular data roaming capability for the mobile device, activates or updates the SIM via the local roaming cellular wireless network, and, after the SIM is activated or updated, disables the cellular data roaming capability for the mobile device.

Processing streaming data in a transaction-based distributed database system

Techniques for implementing a streaming transaction in a transaction based data storage system is disclosed. In an embodiment, a server computer system stores a dataset comprising a plurality of files where the dataset comprises a corresponding version number. The server computer system receives a command to modify the dataset and, in response, starts a streaming transaction for the dataset. During the streaming transaction, the server computer system receives a plurality of updates to the dataset, wherein each of the plurality of updates modifies one or more files of the plurality of files. The server computer system executes the plurality of updates in the dataset without modifying the corresponding version number of the dataset. When the server computer system commits the streaming transaction to the dataset, the server computer system increments the corresponding version number of the dataset.

Storing logical units of program code generated using a dynamic programming notebook user interface

The programming notebook system, methods, and user interfaces described herein provide software developers with enhanced tools by which a programming notebook workflow and session history associated with code cells in a programming notebook may be tracked and maintained. As a developer progresses through a development workflow, the developer can select an option to save a program code card representing some or all of the program code cell inputs. A card editor user interface may present an aggregated listing of all program code the developer has provided across multiple code cells during the current session which the developer can edit, refine, and/or comment. The card editor may also allow the developer to add associated user interface code to display a UI component associated with the program code card, and allow the developer to add a description and tags for the card so that the card can be searched for and reused.

Continuous cell programming devices

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer.

Controlled Delivery of TLR Agonists in Structural Polymeric Devices

The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents. 1. A device comprising a porous polymeric structure composition , a disease-associated antigen , and a toll-like receptor (TLR) agonist , wherein said TLR agonist preferentially binds to TLR3.2. The device of claim 1 , wherein said disease-associated antigen comprises a tumor antigen.3. The device of claim 1 , wherein said polymeric structure composition comprises poly-lactide-co-glycolide (PLG).4. The device of claim 1 , wherein said TLR agonist comprises a TLR3 agonist.5. The device of claim 1 , wherein said TLR3 agonist comprises polyinosine-polycytidylic acid (poly I:C) or PEI-poly (I:C).6. The device of claim 1 , wherein said TLR agonist further comprises pathogen associated molecular patterns (PAMPs).7. The device of claim 1 , wherein said TLR agonist comprises a nucleic acid.8. The device of claim 1 , wherein said TLR agonist further comprises a TLR9 agonist.9. The device of claim 8 , wherein said TLR9 agonist comprises a cytosine-guanosine oligonucleotide (CpG-ODN) or a PEI-CpG-ODN.10. The device of claim 1 , wherein said device further comprises a recruitment composition.11. The device of claim 11 , wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF) claim 11 , Flt3L claim 11 , or CCL20.12. The device of claim 10 , wherein said recruitment composition comprises encapsulated GM-CSF.13. The device of claim 2 , wherein said tumor antigen comprises a tumor lysate claim 2 , purified protein tumor antigen claim 2 , or synthesized tumor antigen.14. The device of claim 6 , wherein said PAMPs comprises a monophosphoryl lipid A (MPLA).15. The device of claim 1 , wherein said device comprises a combination of TLR agonists claim 1 , said combination ...

CUSTOMIZABLE THERMAL CONTROL

An apparatus, system, and method are disclosed for providing customized thermal control data structures. The default thermal control data structure is typically stored in a first storage device of the IOS module of the information processing system. A custom thermal control data structure is stored on a second storage device that is separately updatable from the first storage device. The thermal cooling module that provides cooling for the information processing system is directed to use the custom thermal control data structure for cooling components of the information processing system. 1. An apparatus comprising:one or more storage devices storing machine readable code;one or more processors executing machine readable code, the machine readable code comprising:a customization module that stores a custom thermal control data structure in a second storage device that is separately updatable from a first storage device storing an input output system (IOS) module comprising a default thermal control data structure; anda guidance module that directs a thermal cooling module to use the custom thermal control data structure for cooling one or more components of an information processing system.2. The apparatus of claim 1 , the customization module further receiving one or more values for the custom thermal control data structure and updating the custom thermal control data structure with the one or more values.3. The apparatus of claim 1 , wherein the thermal cooling module uses the default thermal control data structure by default.4. The apparatus of claim 3 , wherein the guidance module directs the thermal cooling module to use the custom thermal control data structure in response to a user selecting the custom thermal control data structure.5. The apparatus of claim 1 , further comprising a setup module that receives a selection of the custom thermal control data structure from a user.6. The apparatus of claim 1 , further comprising a reset module that restores the ...

COMBINED CONTROL LINES FOR DEVICE COOLING FANS

Described is a technology by which two or more air moving devices have some of their control lines combined, including a frequency control line from a controller. Along with the combined frequency control line, power voltage lines and ground lines and may be combined, with a separate sensing line for each air moving device. One or more couplers couples the combined lines to air moving device control circuitry. 1. A system comprising , a controller frequency line configured to conduct frequency signals from a controller to a plurality of air moving devices via one or more couplers , and a combiner configured to combine a frequency line for each of the plurality of air moving devices with one another into a combined frequency line that connects to the controller frequency line.2. The system of wherein the controller resides on a circuit board and at least part of the controller frequency line comprises a circuit board trace claim 1 , wherein the one or more couplers comprises a connector coupled to the circuit board trace and to the combiner claim 1 , and wherein the combiner is external to the circuit board.3. The system of wherein the connector includes two detachable portions claim 2 , including a circuit board connector portion coupled to the circuit board trace of the controller frequency line claim 2 , and an air moving device connector portion having one or more pins corresponding to the air moving device frequency lines.4. The system of wherein the controller resides on a circuit board and at least part of the controller frequency line comprises a controller circuit board trace claim 1 , wherein the one or more couplers comprises a plurality of connectors claim 1 , one connector for each air moving device claim 1 , in which the connector for each air moving device is configured to couple the frequency line of that air moving device to a separate circuit board trace for that connector claim 1 , and wherein the combiner combines the separate circuit board traces ...

DETECTION OF DISPLAYPORT ALTERNATE MODE COMMUNICATION AND CONNECTOR PLUG ORIENTATION WITHOUT USE OF A POWER DISTRIBUTION CONTROLLER

This disclosure generally relates to USB TYPE-C, and, in particular, DISPLAYPORT Alternate Mode communication in a USB TYPE-C environment. In one embodiment, a device determines a DISPLAYPORT mode and determines an orientation of a USB TYPE-C connector plug. A multiplexer multiplexes a DISPLAYPORT transmission based in part on the determined orientation of the USB TYPE-C connector plug. 1. A method , comprising:{'b': 1', '2, 'determining, by a device, a DisplayPort mode by detecting a received signal on a first sideband use (SBU) pin of the device or a second sideband use (SBU) pin of the device;'}determining, by the device, an orientation of a USB Type-C connector plug by detecting a type of the received signal;multiplexing, by a multiplexer, a DisplayPort transmission based in part on the determined orientation of the USB Type-C connector plug; andmultiplexing, by the multiplexer, the received signal based in part on the determined orientation of the USB Type-C connector plug.2. A method , comprising:{'b': 1', '2, 'determining, by a device, a DisplayPort mode by detecting a received signal on a first sideband use (SBU) pin of the device or a second sideband use (SBU) pin of the device;'}determining, by the device, an orientation of a USB Type-C connector plug; andmultiplexing, by a multiplexer, a DisplayPort transmission based in part on the determined orientation of the USB Type-C connector plug.3. (canceled)41212. The method of claim 2 , wherein detecting a received signal on a SBU pin of the device or a SBU pin of the device comprises detecting a pull up in either the SBU pin or the SBU pin.5. The method of claim 2 , further comprising multiplexing claim 2 , by the multiplexer claim 2 , the received signal based in part on the determined orientation of the USB Type-C connector plug.6. The method of claim 2 , wherein determining an orientation of a USB Type-C connector plug comprises determining an orientation of a USB Type-C connector plug by detecting a type ...

Scaffolds For Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 1. A cancer vaccine device comprising a scaffold composition comprising a polymer matrix and having open , interconnected macropores;a granulocyte-macrophage colony stimulating factor (GM-CSF) that recruits immune cells selected from macrophages, T-cells, B-cells, NK cells, and dendritic cells;a tumor antigen; andan immune response-promoting bioactive factor comprising an oligonucleotide, wherein the GM-CSF, the tumor antigen, or the immune response-promoting bioactive factor is incorporated into or coated onto said scaffold composition.2. The device of claim 1 , wherein said device further comprises an extracellular matrix (ECM) component.3. The device of claim 2 , wherein said ECM component comprises an arginine-glycine-aspartate (RGD) sequence.4. The device of claim 1 , wherein the GM-CSF claim 1 , tumor antigen claim 1 , or immune response-promoting bioactive factor is covalently linked to said scaffold composition.5. The device of claim 1 , wherein the tumor antigen comprises biopsy-extracted antigens.6. The device of claim 1 , wherein the tumor antigen comprises a tumor cell lysate.710-. (canceled)11. The device of claim 1 , wherein the scaffold composition degrades at a predetermined rate based on a physical parameter selected from the group consisting of temperature claim 1 , pH claim 1 , hydration status claim 1 , and porosity.12. (canceled)13. The device of claim 1 , wherein said scaffold composition comprises pores of greater than 100 μm in size.14. The device of claim 13 , wherein the scaffold composition comprises pores of 400-500 μm in size.1525-. (canceled)26. The ...

RVG DERIVED PEPTIDES

The invention relates to short RVG derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides. 1. A peptide comprising the structure:{'sup': 1', '2, 'A-B-C or C-B-A, wherein B is optionally present or absent; and wherein'}{'sup': '1', 'Acomprises the sequence CDIFTNSRGK (SEQ ID NO:2) or a variant or derivative thereof;'}{'sup': '2', 'Acomprises the sequence kGrsntfidc (SEQ ID NO:3) or a variant or derivative thereof;'}B is a linker sequence; andC is a cell penetrating peptide (CPP) sequence.2. The peptide according to wherein the peptide has the sequence of CDIFTNSRGKGGGGrrrrrrrrr (SED ID NO:4).3. The peptide according to wherein the peptide has the sequence rrrrrrrrr-Sar-Sar-Sar-Sar-kGrsntfidc (SED ID NO:5).4. The peptide according to further comprising the linker sequence.5. The peptide according to wherein the linker sequence is a glycine or sarcosine sequence.6. The peptide according to wherein the cell penetrating peptide sequence is a polymeric arginine residue.7. The peptide according to wherein the cell penetrating peptide sequence is a 9 arginine residue sequence.8. (canceled)9. (canceled)10. A composition comprising the peptide according to and an agent associated with the peptide.11. The composition according to wherein the agent is a nucleic acid or an analogue thereof.12. The composition according to wherein the agent is RNA and is selected from the group consisting of siRNA claim 10 , mRNA claim 10 , tRNA claim 10 , miRNA claim 10 , shRNA or analogues or combinations thereof.13. The composition according to when the agent is an α-synuclein siRNA molecule.14. The composition according to wherein the agent is an siRNA molecule having the sequence of SEQ ID NO: 6.15. (canceled)16. (canceled)17 ...

SCAFFOLDS FOR CELL COLLECTION OR ELIMINATION

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host. 19.-. (canceled)10. A method of removing or eliminating an autoimmune cell from a mammalian subject , comprisinga) administering to the subject a device comprising a scaffold composition and a bioactive composition, said bioactive composition being incorporated into or conjugated onto said scaffold composition, wherein said scaffold composition comprises a polymer matrix and pores, and wherein the bioactive composition comprises a cell attractant,b) exposing said autoimmune cell to said cell attractant, thereby recruiting the autoimmune cell to the scaffold composition,c) capturing said autoimmune cell within said scaffold composition, thereby sequestering said autoimmune cell from the host environment, thereby removing or eliminating the autoimmune cell from the subject.1145.-. (canceled)46. The method of claim 10 , wherein the device is administered orally claim 10 , systemically claim 10 , intravenously claim 10 , intraperitoneally claim 10 , by intramuscular injection claim 10 , by lumbar puncture to access cerebral spinal fluid claim 10 , subcutaneously claim 10 , transcutaneously claim 10 , as an arterial stent claim 10 , or surgically.4751.-. (canceled)52. The method of claim 10 , further comprising the step of collecting the device from the subject.53. The method of claim 10 , wherein the cell attractant comprises a multivalent acrylamide polymer linked to a sugar claim 10 , a polylysine linked to a sugar claim 10 , a cytokine claim 10 , or a chemokine.54. The method of claim 53 , wherein the sugar comprises ...

Combination Vaccine Devices and Methods of Killing Cancer Cells

The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer. 1. A device comprising:a) an inhibitor of an immune-inhibitory protein;b) a scaffold composition;c) a cell recruitment composition; andd) a bioactive composition, wherein the bioactive composition is incorporated into or coated onto the scaffold composition, and wherein the bioactive composition causes modification of cells in or recruited to the device.2. The device of claim 1 , wherein the immune-inhibitory protein is selected from the group consisting of cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) claim 1 , programmed cell death protein 1 (PD1) claim 1 , programmed cell death protein 1 ligand (PDL1) claim 1 , lymphocyte activation gene 3 (LAG3) claim 1 , B7-H3 claim 1 , B7-H4 claim 1 , and T cell membrane protein 3 (TIM3).3. The device of claim 2 , wherein the immune-inhibitory protein is CTLA4.4. The device of claim 2 , wherein the immune-inhibitory protein is PD1.5. The device of claim 1 , comprising an inhibitor of CTLA4 and an inhibitor of PD1.6. The device of claim 1 , wherein the inhibitor comprises a protein claim 1 , peptide claim 1 , or nucleic acid.7. The device of claim 2 , wherein the inhibitor comprises an antibody or fragment thereof.8. The device of wherein the antibody or fragment thereof binds to CTLA4.9. The device of claim 8 , wherein the antibody or fragment thereof is Ipilimumab claim 8 , Tremelimumab claim 8 , or a fragment thereof.10. The device of claim 2 , wherein the inhibitor binds to PD1 claim 2 , and wherein the inhibitor is a protein.11. The device of claim 10 , wherein the inhibitor is MDX-1106 claim 10 , MK3475 claim 10 , CT-011 claim 10 , AMP-224 claim 10 , or a fragment thereof.12. The device of claim 10 , wherein the inhibitor is a PDL2-immunoglobulin (Ig) fusion protein.13. The device of claim 2 , wherein the ...

DETECTION OF DISPLAYPORT ALTERNATE MODE COMMUNICATION AND CONNECTOR PLUG ORIENTATION WITHOUT USE OF A POWER DISTRIBUTION CONTROLLER

This disclosure generally relates to USB TYPE-C, and, in particular, DISPLAYPORT Alternate Mode communication in a USB TYPE-C environment. In one embodiment, a device determines a DISPLAYPORT mode and determines an orientation of a USB TYPE-C connector plug. A multiplexer multiplexes a DISPLAYPORT transmission based in part on the determined orientation of the USB TYPE-C connector plug. 1. A method , comprising:determining, by a device, a mode by detecting a received signal on an active pin of the device, wherein the active pin is one of a first pin of the device and a second pin of the device;determining, by the device, a determined orientation of a connector based on the active pin; andtransmitting, by the device, a transmission based on the determined orientation of the connector.2. The method of claim 1 , wherein:the mode is a DisplayPort mode; andthe transmission is a DisplayPort transmission.3. The method of claim 1 , wherein:the first pin is a first sideband use pin; andthe second pin is a second sideband use pin.4. The method of claim 1 , wherein:the connector is a USB Type-C connector plug.5. The method of claim 1 , wherein:detecting the received signal on the active pin of the device includes detecting a voltage above a threshold in either the first pin or the second pin.6. The method of claim 1 , further comprising:a third pin of the device coupled to the first pin of the device or the second pin of the device;a fourth pin of the device coupled to the first pin of the device or the second pin of the device; anddetecting, by the device, the received signal at one of the third pin and the fourth pin.7. The method of claim 6 , wherein:the determined orientation of the connector is further based on the one of the third pin and the fourth pin at which the received signal is detected.8. The method of claim 6 , wherein:the third pin of the device is one of a positive auxiliary and a negative auxiliary.9. The method of claim 6 , wherein:the fourth pin of the ...

DETECTION OF DISPLAYPORT ALTERNATE MODE COMMUNICATION AND CONNECTOR PLUG ORIENTATION WITHOUT USE OF A POWER DISTRIBUTION CONTROLLER

This disclosure generally relates to USB TYPE-C, and, in particular, DISPLAYPORT Alternate Mode communication in a USB TYPE-C environment. In one embodiment, a device determines a DISPLAYPORT mode and determines an orientation of a USB TYPE-C connector plug. A multiplexer multiplexes a DISPLAYPORT transmission based in part on the determined orientation of the USB TYPE-C connector plug. 1. A method , comprising:determining, by a device, a DisplayPort mode by detecting a received signal on a first sideband use (SBU1) pin of the device or a second sideband use (SBU2) pin of the device;determining, by the device, an orientation of a USB Type-C connector plug by detecting a type of the received signal;multiplexing, by a multiplexer, a DisplayPort transmission based in part on the determined orientation of the USB Type-C connector plug; andmultiplexing, by the multiplexer, the received signal based in part on the determined orientation of the USB Type-C connector plug.2. A method , comprising:determining, by a device, a DisplayPort mode by detecting a received signal on a first sideband use (SBU1) pin of the device or a second sideband use (SBU2) pin of the device;determining, by the device, an orientation of a USB Type-C connector plug; andmultiplexing, by a multiplexer, a DisplayPort transmission based in part on the determined orientation of the USB Type-C connector plug.3. The method of claim 2 , wherein detecting a received signal on a SBU1 pin of the device or a SBU2 pin of the device comprises detecting a pull up in either the SBU1 pin or the SBU2 pin.4. The method of claim 2 , further comprising multiplexing claim 2 , by the multiplexer claim 2 , the received signal based in part on the determined orientation of the USB Type-C connector plug.5. The method of claim 2 , wherein determining an orientation of a USB Type-C connector plug comprises determining an orientation of a USB Type-C connector plug by detecting a type of the received signal.6. The method of ...

SCAFFOLDS FOR CELL TRANSPLANTATION

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 125-. (canceled)26. A device for modulating immune cell activity in a subject comprising:a scaffold composition comprising a polymer matrix and having open, interconnected macropores;a recruitment composition that recruits an immune cell to the scaffold; anda bioactive composition that modulates the activity of the immune cell.27. The device of claim 26 , further comprising an adjuvant.28. The device of claim 27 , wherein the adjuvant is selected from the group consisting of a chemokine claim 27 , a cytokine claim 27 , a CpG rich oligonucleotide claim 27 , an antibody claim 27 , and any combination thereof.29. The device of claim 27 , wherein the adjuvant comprises a CpG rich oligonucleotide.30. The device of claim 26 , further comprising a deployment signal that induces egress of the immune cell from the scaffold.31. The device of claim 30 , wherein the deployment signal is selected from the group consisting of a polypeptide claim 30 , a nucleic acid claim 30 , and any combination thereof.32. The device of claim 30 , wherein the deployment signal is a reduction in claim 30 , or absence of claim 30 , the recruitment composition.33. The device of claim 26 , wherein the bioactive composition modulates the activity of the immune cell while the immune cell resides in the macropores of the scaffold.34. The device of claim 26 , wherein the scaffold composition degrades at a predetermined rate based on a physical parameter selected from the group consisting of temperature claim 26 , pH claim 26 , hydration status claim 26 , and porosity.35. The device of claim 26 , wherein the scaffold ...

Alpha-Synuclein Antibodies (7A11)

The invention relates to an antibody or fragment thereof and the use of the antibody in a method of treatment and/or diagnosis. The antibody or fragment thereof specifically binds to alpha-synuclein, including monomeric, oligomeric and fibril forms of alpha-synuclein; is not cross reactive with beta-synuclein or gamma-synuclein; specifically binds human, rat and mouse alpha-synuclein; binds nitrated, oxidized and phosphorylated forms of alpha-synuclein; and binds an epitope of human alpha synuclein comprising the sequence MPSEEGYQDYEPEA (SEQ ID NO:2). The method for diagnosing a neurodegenerative disease associated with alpha-synuclein or for detecting alpha-synuclein, comprises adding the antibody or fragment thereof to a biological sample from a subject, and detecting the presence or absence of a complex formed between alpha-synuclein and the antibody or fragment. 1. An antibody or fragment thereof specifically binding to alpha-synuclein , wherein the antibody or fragment thereof:binds monomeric, oligomeric and fibril forms of alpha-synuclein;is not cross reactive with beta-synuclein or gamma-synuclein;specifically binds human, rat and mouse alpha-synuclein;binds nitrated, oxidized and phosphorylated forms of alpha-synuclein; andbinds an epitope of human alpha synuclein comprising the sequence MPSEEGYQDYEPEA (SEQ ID NO:2).2. An antibody or fragment thereof according to wherein the antibody or fragment thereof has a dissociation constant claim 1 , Kd claim 1 , of less than 10M for alpha-synuclein.3. An antibody or fragment thereof according to claim 1 , wherein the antibody does not cross react with IAPP (islet amyloid polypeptide) claim 1 , β-amyloid monomers claim 1 , Tau or ABri.4. An antibody or fragment thereof according to claim 1 , wherein the antibody is a monoclonal antibody.5. An antibody or fragment thereof according to claim 1 , wherein the antibody is an IgG2a antibody.6. An antibody or fragment thereof according to claim 1 , wherein the antibody has a ...

Alpha-Synuclein Antibodies (4H6)

The invention relates to an antibody or fragment thereof and to a method of treatment and/or diagnosis using the antibody or fragment thereof. The antibody or fragment thereof is capable of binding to human alpha-synuclein, including monomeric, oligomeric and fibril forms of alpha-synuclein; is cross reactive with beta-synuclein and gamma synuclein; and binds an epitope of human alpha synuclein comprising the sequence MPSEEGYQDYEPEA (SEQ ID NO:2). A method for diagnosing a neurodegenerative disease associated with alpha-synuclein or of detecting alpha-synuclein comprises adding the antibody or fragment thereof to a biological sample from a subject, and detecting the presence or absence of a complex formed between alpha-synuclein and the antibody or fragment.

Alpha-Synuclein Antibodies (11D12)

The invention relates to an antibody or fragment thereof and a method of treatment and/or diagnosis using the antibody. The antibody or fragment thereof binds to human alpha-synuclein including monomeric, oligomeric and fibril forms of alpha-synuclein; is not cross reactive with beta-synuclein or gamma synuclein; specifically binds human alpha-synuclein and is not cross reactive with rat or mouse alpha-synuclein; binds nitrated, oxidized and phosphorylated forms of alpha-synuclein; and binds an epitope of human alpha synuclein comprising the sequence LEDMPVDPDNEAYE (SEQ ID NO:2). A method for diagnosing a neurodegenerative disease associated with alpha-synuclein or of detecting alpha-synuclein, comprises adding the antibody or fragment thereof to a biological sample from a subject, and detecting the presence or absence of a complex formed between alpha-synuclein and the antibody or fragment. 1. An antibody or fragment thereof specifically binding to human alpha-synuclein , wherein the antibody or fragment thereof:binds monomeric, oligomeric and fibril forms of alpha-synuclein;is not cross reactive with beta-synuclein or gamma synuclein;specifically binds human alpha-synuclein and is not cross reactive with rat or mouse alpha-synuclein;binds nitrated, oxidized and phosphorylated forms of alpha-synuclein; andbinds an epitope of human alpha synuclein comprising the sequence LEDMPVDPDNEAYE (SEQ ID NO:2).2. An antibody or fragment thereof according to claim 1 , wherein the antibody or fragment thereof has a dissociation constant claim 1 , Kd claim 1 , of less than 10M for human alpha-synuclein.3. An antibody or fragment thereof according to claim 1 , wherein the antibody does not cross react with IAPP (islet amyloid polypeptide) claim 1 , β-amyloid monomers claim 1 , Tau or ABri.4. An antibody or fragment thereof according to claim 1 , wherein the antibody is a monoclonal antibody.5. An antibody or fragment thereof according to claim 1 , wherein the antibody is an IgG2a ...

PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAME

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein. 1. A vaccine composition , comprisingan opsonin-bound or lectin-bound pathogen construct, and a bioagent capable of recruiting an immune cell in a subject.258-. (canceled)59. A method of treating a pathogen infection in a subject in need thereof claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby treating the pathogen infection in the subject.60. A method of vaccinating a subject against a pathogen infection claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby vaccinating the subject against the pathogen infection.61. A method of treating an antibiotic-resistant bacterial infection in a subject in need thereof claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby treating the antibiotic-resistant bacterial infection in the subject.62. (canceled)63. A method of decreasing the level of a pathogen in a subject having a pathogen infection claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby decreasing the level of the pathogen in the subject. ...

TECHNIQUES FOR CONTROLLING HYBRID AUTOMATIC REPEAT REQUEST (HARQ)

Methods, systems, and devices for wireless communications are described. A user equipment (UE) may adaptively switch between hybrid automatic repeat request (HARQ) monitoring modes to support power savings. In a first HARQ skipping mode, the UE may transmit an uplink message corresponding to a HARQ identifier and may receive a positive acknowledgment (ACK) message in a HARQ monitoring occasion associated with the HARQ identifier. Upon receiving the ACK message, the UE refrains from monitoring a subsequent HARQ monitoring occasion associated with the HARQ identifier while in the first HARQ skipping mode (e.g., an aggressive HARQ skipping mode). The UE may periodically enter a periodic evaluation mode from the first HARQ skipping mode, in which the UE monitors a subsequent HARQ monitoring occasion after receiving an ACK message to check for false ACK messages. If a false ACK message is detected, the UE enters a first HARQ skipping prohibited mode. 1. A method for wireless communications at a user equipment (UE) , comprising:transmitting a first uplink message corresponding to a first hybrid automatic repeat request (HARQ) identifier;receiving, in a first HARQ monitoring occasion associated with the first HARQ identifier, a first positive acknowledgment HARQ message;refraining, when in a first HARQ skipping mode, from monitoring a first subsequent HARQ monitoring occasion associated with the first HARQ identifier based at least in part on receiving the first positive acknowledgment HARQ message;entering a periodic evaluation mode after a time threshold of operating in the first HARQ skipping mode;transmitting a second uplink message corresponding to a second HARQ identifier;receiving, in a second HARQ monitoring occasion associated with the second HARQ identifier, a second positive acknowledgment HARQ message; andmonitoring, when in the periodic evaluation mode, a second subsequent HARQ monitoring occasion associated with the second HARQ identifier based at least in ...

Optical Sensor with Trench Etched Through Dielectric Over Silicon

In described examples an integrated circuit (IC) has multiple layers of dielectric material overlying at least a portion of a surface of a substrate. A trench is etched through the layers of dielectric material to expose a portion the substrate to form a trench floor, the trench being surrounded by a trench wall formed by the layers of dielectric material. A metal perimeter band surrounds the trench adjacent the trench wall, the perimeter band being embedded in one of the layers of the dielectric material. 1. An integrated circuit (IC) comprising:a substrate having a first surface and an opposite second surface;layers of dielectric material overlying at least a portion of the first surface of the substrate;a trench etched through the layers of dielectric material to expose a portion the substrate to form a trench floor, the trench being surrounded by a trench wall formed by the layers of dielectric material; anda metal perimeter band surrounding the trench adjacent the trench wall, the perimeter band being embedded in one of the layers of the dielectric material.2. The IC of claim 1 , wherein the metal perimeter band is a remaining portion of a metal plate etch stop separated from the substrate by only one of the layers of dielectric material.3. The IC of claim 1 , further comprising an optical sensor located in the exposed portion of the substrate adjacent the trench.4. The IC of claim 3 , further comprising an anti-reflective coating deposited on the trench floor and the trench wall.5. The IC of claim 4 , wherein the anti-reflective coating is a single layer of material.6. The IC of claim 4 , wherein the anti-reflective coating is a single layer of silicon nitride.7. The IC of claim 1 , further comprising a polymer filter material located within the region of the trench.8. The IC of claim 7 , wherein the polymer filter material has a convex surface protruding away from trench.9. The IC of claim 1 , wherein the metal perimeter band is a first metal perimeter band ...

IMMUNE CELL TRAPPING DEVICES AND METHODS FOR MAKING AND USING THE SAME

Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers. 1. An immune-cell trapping device , comprisinga physiologically-compatible porous polymer scaffold, anda plurality of purified antigens,wherein the plurality of antigens attract and trap a plurality of immune cells specific to the plurality of antigens in the device.2. The device of claim 1 , wherein the antigens are absorbed onto the polymer scaffold or are encapsulated by the polymer scaffold.35.-. (canceled)6. The device of claim 1 , wherein the device further comprises an immune cell recruiting agent.7. The device of claim 6 , wherein the immune cell recruiting agent:comprises an agent selected from the group consisting of a T-cell recruiting agent, a dendritic cell recruiting agent, and a macrophage recruiting agent, or a combination thereof;comprises an agent selected from the group consisting of natural killer (NK) cell recruiting agent, a CD3+ T-cell recruiting agent, a CD4+ T-cell recruiting agent, a CD8+ T cell recruiting agent, a CD8+ T cell recruiting agent, a regulatory T-cell (Treg) recruiting agent, or a combination thereof; oris a growth factor, a cytokine, an interleukin, ...

WIRELESS DEVICE WITH SUBSTRATE TO ANTENNA COUPLING

A device comprises an integrated circuit (IC) die, a substrate, a printed circuit board (PCB), an antenna, and a waveguide stub. The IC die is affixed to the substrate, which comprises a signal launch on a surface of the substrate that is configured to emit or receive a signal. The substrate and the antenna are affixed to the PCB, such that the signal launch and a waveguide opening of the antenna are aligned and comprise a signal channel. The waveguide stub is arranged as a boundary around the signal channel. In some implementations, the waveguide stub has a height of λ/4, where λ represents a wavelength of the signal. In some implementations, the antenna includes the waveguide stub; in others, the substrate includes the waveguide stub. 1. A device , comprising:a printed circuit board (PCB);a substrate affixed to the PCB and comprising a signal launch on a surface of the substrate configured to emit or receive a signal;an integrated circuit (IC) die affixed to the substrate;an antenna comprising a waveguide opening and affixed to the PCB, wherein the signal launch and the waveguide opening are aligned and comprise a signal channel; anda waveguide stub arranged as a boundary around the signal channel.2. The device of claim 1 , wherein the waveguide stub has a height of λ/4 claim 1 , wherein λ represents a wavelength of the signal.3. The device of claim 1 , wherein a center of the waveguide stub is a distance less than λ from a center of the signal channel claim 1 , wherein λ represents a wavelength of the signal.4. The device of claim 1 , wherein the antenna further comprises the waveguide stub arranged as a boundary around the waveguide opening.5. The device of claim 1 , wherein the substrate further comprises the waveguide stub arranged as a boundary around the signal launch.6. The device of claim 5 , wherein the waveguide stub is straight in the substrate in a direction normal to the surface of the substrate claim 5 , and wherein a thickness of the substrate is at ...

TERMINATIONLESS POWER SPLITTER/COMBINER

An apparatus is provided. First and second hybrid couplers are provided with each having a first port, a second port, a third port, a fourth port and with each being substantially curvilinear. The fourth ports of the first and second hybrid couplers are first and second isolation port that are mutually coupled. The first port of the first hybrid coupler is configured to carry a first portion of a differential signal, and the first port of the second hybrid coupler is configured to carry a second portion of the differential signal. 1. An apparatus comprising:an integrated circuit (IC); and a first hybrid coupler having a first port, a second port, a third port, and a fourth port, wherein the fourth port of the first hybrid coupler is a first isolation port, and wherein the first port of the first hybrid coupler is configured to carry a first portion of a differential signal, and wherein the first hybrid coupler is substantially curvilinear, and wherein the first port of the first hybrid coupled is coupled to the IC;', 'a second hybrid coupler having a first port, a second port, a third port, and a fourth port, wherein the fourth port of the second hybrid coupler is a second isolation port, and wherein the first port of the second hybrid coupler is configured to carry a second portion of the differential signal, and wherein the second hybrid coupler is substantially curvilinear, and wherein the first and second isolation ports are mutually coupled, and wherein the first port of the second hybrid coupled is coupled to the IC;', 'a third hybrid coupler having a first port, a second port, a third port, and a fourth port, wherein the fourth port of the third hybrid coupler is a third isolation port, and wherein the first port of the third hybrid coupler is configured to carry the first portion of the differential signal, and wherein the third hybrid coupler is substantially curvilinear, and wherein the first port of the third hybrid coupled is coupled to the IC;', 'a ...

CONTINUOUS CELL PROGRAMMING DEVICES

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer. 122.-. (canceled)23. A device comprising an anionic scaffold composition , a tumor antigen , a recruitment composition , and a deployment composition , said deployment composition comprising a condensed toll-like receptor-9 (TLR-9)-activating CpG-ODN cationic nanoparticle , said cationic nanoparticle being retained in or on said anionic scaffold via electrostatic interactions.24. The device of claim 23 , further comprising a dendritic cell attracted into the device after the device is introduced into a subject.25. The device of claim 24 , wherein the dendritic cell comprises a plasmacytoid dendritic cell.26. The device of claim 24 , which enhances CpG-ODN uptake into said dendritic cell.27. The device of claim 24 , wherein said dendritic cell is activated by the device.28. The device of claim 23 , wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF).29. The device of claim 23 , wherein the recruitment composition is encapsulated.30. The device of claim 29 , wherein the encapsulated recruitment composition comprises GM-CSF.31. The device of wherein a pulse of said recruitment composition is released from said device within 1-7 days after said device is introduced into a subject claim 29 , leaving a residual amount of said recruitment composition followed by slow release of residual amount over several weeks.32. The device of claim 31 , wherein said pulse comprises at least 50% of the amount of said recruitment composition associated with said device.33. The device of claim 31 , wherein said pulse comprises release of at least 60% of the amount of said recruitment composition associated with said device in 1-5 ...

Continuous Cell Programming Devices

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer. 122.-. (canceled)23. A device comprising a scaffold composition , a tumor antigen , a recruitment composition , and a deployment composition , wherein said deployment composition comprises a TLR3 agonist.24. The device of claim 23 , wherein said TLR3 agonist comprises a nucleic acid.25. The device of claim 24 , wherein said nucleic acid comprises a synthetically produced nucleic acid.26. The device of claim 25 , wherein said synthetically produced nucleic acid comprises double-stranded RNA.27. The device of claim 26 , wherein said nucleic acid comprises poly I:C.28. The device of claim 23 , further comprising a dendritic cell attracted into the device after the device is introduced into a subject.29. The device of claim 28 , wherein the dendritic cell comprises a plasmacytoid dendritic cell.30. The device of claim 28 , wherein said dendritic cell is activated by the device.31. The device of claim 23 , wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF).32. The device of claim 23 , wherein the recruitment composition is encapsulated.33. The device of claim 32 , wherein the encapsulated recruitment composition comprises GM-CSF.34. The device of claim 32 , wherein a pulse of said recruitment composition is released from said device within 1-7 days after said device is introduced into a subject claim 32 , leaving a residual amount of said recruitment composition followed by slow release of residual amount over several weeks.35. The device of claim 34 , wherein said pulse comprises at least 50% of the amount of said recruitment composition associated with said device.36. The device of claim 34 , wherein said ...

Continuous Cell Programming Devices

The present invention comprises compositions, methods, and devices for creating an infection-mimicking environment within a polymer scaffold to stimulate antigen-specific dendritic cell activation. Devices of the present invention are used to provide protective immunity to subjects against infection and cancer. 122.-. (canceled)23. A device comprising a scaffold composition , a tumor antigen , a recruitment composition , and a deployment composition , wherein said deployment composition comprises a TLR7 agonist.24. The device of claim 23 , wherein said TLR7 agonist comprises a dinucleotide.25. The device of claim 23 , wherein said TLR7 agonist comprises a small synthetic compound.26. The device of claim 25 , wherein the small synthetic compound is a small molecule.27. The device of claim 23 , wherein said TLR7 agonist comprises single-stranded RNA.28. The device of claim 23 , wherein said TLR7 agonist comprises a bacterially-derived immunomodulator.29. The device of claim 23 , wherein said TLR7 agonist comprises a bacterial product.30. The device of claim 23 , wherein said TLR7 agonist comprises a polymer.31. The device of claim 23 , wherein said TLR7 agonist comprises a sugar moiety associated with bacteria.32. The device of claim 23 , further comprising a dendritic cell attracted into the device after the device is introduced into a subject.33. The device of claim 32 , wherein the dendritic cell comprises a plasmacytoid dendritic cell.34. The device of claim 32 , wherein said dendritic cell is activated by the device.35. The device of claim 23 , wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF).36. The device of claim 23 , wherein the recruitment composition is encapsulated.37. The device of claim 36 , wherein the encapsulated recruitment composition comprises GM-CSF.38. The device of claim 36 , wherein a pulse of said recruitment composition is released from said device within 1-7 days after said device is ...

BIOMATERIALS FOR MODULATING IMMUNE RESPONSES

The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens. 1. A device comprising:(a) a delivery vehicle comprising a scaffold composition, and(b) (i) polyethylenimine (PEI); (ii) free PEI; (iii) PEI and an antigen; or (iv) PEI attached to an antigen.2. The device of claim 1 , comprising PEI and an antigen or PEI attached to an antigen claim 1 , wherein said antigen comprises a tumor antigen or a non-tumor antigen.3. The device of claim 2 , wherein said PEI is attached to said antigen via an electrostatic interaction or a covalent bond.4. (canceled)5. The device of claim 1 , wherein(i) said PEI is branched or linear;(ii) the device comprises both branched PEI and linear PEI;(iii) said PEI comprises branched dendrimeric PEI;(iv) said PEI comprises at least about 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, or 30 primary, secondary, and/or tertiary amino groups;(v) said PEI comprises a molecular weight of (a) at least about 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 100, 125, 150, 175, or 200 kilodaltons (kDa); (b) less than about 200, 175, 150, 125, 100, 75, 70, 65, 60, 55, 50, 45, 35, 25, 20, 15, 10, 5, 4, 3, 2, or 1 kDa; or (c) about 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 1-10, 2-25, 25-60, 25-75, 50-100, or 100-200 kDa; and/or(vi) said PEI comprises linear PEI having a molecular weight of about 25 kDa or branched PEI having a molecular weight of about 60 kDa.610-. (canceled)11. The device of claim 1 , wherein said delivery vehicle comprises a volume of at least about 0.1 claim 1 , 0.5 claim 1 , 1 claim 1 , 10 claim 1 , 20 claim 1 , 30 claim 1 , 40 claim 1 , 50 claim 1 , 60 claim 1 , 70 claim 1 , 80 claim 1 , 90 claim 1 , or 100 mm.12. The device of claim 1 , wherein said scaffold composition (i) comprises open interconnected macropores; (ii) is a pore-forming scaffold composition claim 1 , (iii) comprises a hydrogel or a cryogel; (iv) is anionic or ...

PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAME

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein. 1. A vaccine composition , comprisingan opsonin-bound or lectin-bound pathogen construct, and a bioagent capable of recruiting an immune cell in a subject.258-. (canceled)59. A method of treating a pathogen infection in a subject in need thereof claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby treating the pathogen infection in the subject.60. A method of vaccinating a subject against a pathogen infection claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby vaccinating the subject against the pathogen infection.61. A method of treating an antibiotic-resistant bacterial infection in a subject in need thereof claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby treating the antibiotic-resistant bacterial infection in the subject.62. (canceled)63. A method of decreasing the level of a pathogen in a subject having a pathogen infection claim 1 , comprising administering the vaccine composition of to the subject claim 1 , thereby decreasing the level of the pathogen in the subject. ...

DIFFERENTIAL MEASUREMENT OF IR ABORPTION IN PLASMONIC MEMS SENSORS

A differential nondispersive infrared (NDIR) sensor incorporates an infrared (IR) chopper and multiple multi-bit digital registers to store and compare parameter ratio values, as may be digitally calibrated to corresponding temperature values, from chopper clock cycle portions in which a plasmonic MEMS detector is irradiated by the IR chopper with such values from chopper clock cycle portions in which the IR detector is not irradiated by the IR chopper. The plasmonic MEMS detector is referenced to a reference MEMS device via a parameter-ratio engine. The reference device can include a broadband IR reflector or can have a lower-absorption metasurface pattern giving it a lower quality factor than the plasmonic detector. The resultant enhancements to accuracy and precision of the NDIR sensor enable it to be used as a sub-parts-per-million gas concentration sensor or gas detector having laboratory, commercial, in-home, and battlefield applications.

Transport block size for channels with shortened transmission time interval

Systems, apparatuses, and methods for computing transport block size (TB S) for channels with shortened transmission time interval (sTTI). An initial size may be determined based on one or more TBS tables. The initial size may be scaled by a factor associated with an sTTI channel. A TBS table is selected based on the one or more TBS tables. The scaled size may be rounded based on the selected TBS table to generate a TBS for the sTTI channel.

SCAFFOLDS FOR CELL TRANSPLANTATION

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 125-. (canceled)26. A vaccine device for enhancing an immune response to a microorganism comprising:a scaffold comprising open, interconnected macropores;a cell recruitment signal that recruits immune cells to the scaffold; anda microbial antigen, wherein the antigen is incorporated into or coated onto the scaffold, and wherein the antigen enhances an immune response to the microorganism.271. The device of claim , wherein said antigen comprises an infectious disease associated antigen.281. The device of claim , wherein the scaffold composition comprises pores greater than 20 μm in size.291. The device of claim , wherein the scaffold composition comprises pores in the range of 400 μm to 500 μm in size.301. The device of claim , wherein the scaffold is selected from polylactic acid , polyglycolic acid , poly(lactide-co-glycolide)(PLGA) polymers , alginates and alginate derivatives , gelatin , collagen , fibrin , hyaluronic acid , laminin rich gels , agarose , natural and synthetic polysaccharides , polyamino acids , polypeptides , polyesters , polyanhydrides , polyphosphazines , poly(vinyl alcohols) , poly(alkylene oxides) , poly(allylamines)(PAM) , poly(acrylates) , modified styrene polymers , pluronic polyols , polyoxamers , poly(uronic acids) , polyvinylpyrrolidone) and combinations , copolymers , or graft copolymers thereof.311. The device of claim , wherein the scaffold comprises a poly(lactide-co-glycolide)(PLGA) polymer; an alginate; or an alginate and a derivative thereof.321. The device of claim , wherein the cell recruitment signal comprises granulocyte macrophage colony ...

DETECTION AND IDENTIFCATION OF SUPPORTED CONNECTION PROTOCOLS IN A MULTI-PURPOSE STORAGE BAY

An embodiment provides a method, including: providing a multi-protocol connector in an electronic device for connecting at least one storage device thereto; determining, using an operative coupling between the multi-protocol connector and the electronic device, if the electronic device supports one or more protocols of the multi-protocol connector; and providing an informational prompt for each determined protocol of the multi-protocol connector that the electronic device supports. Other aspects are described and claimed. 1. A method , comprising:providing a multi-protocol connector in an electronic device for connecting at least one storage device thereto;determining, using an operative coupling between the multi-protocol connector and the electronic device, if the electronic device supports one or more protocols of the multi-protocol connector; andproviding an informational prompt for each determined protocol of the multi-protocol connector that the electronic device supports.2. The method of claim 1 , wherein said determining comprises determining if the multi-protocol connector is operatively coupled to a storage controller of a particular type.3. The method of claim 1 , wherein said determining comprises determining claim 1 , using one or more pins of a storage controller of the electronic device and switching logic claim 1 , a type of the storage controller with respect to a protocol of the multi-protocol connector.4. The method of claim 1 , wherein said providing of an informational prompt comprises illuminating a light-emitting element for each determined protocol of the multi-protocol connector that the electronic device supports.5. The method of claim 4 , further comprising:detecting a connection of a storage device to the multi-protocol connector; andthereafter deactivating one or more light-emitting elements.6. The method of claim 5 , wherein the at least one storage device is selected from the group of storage devices consisting of a hard disk drive and ...

Closed-loop control and monitoring in cooling electronic components

An embodiment provides a method, including: receiving, from a temperature sensor disposed within an electronic device, temperature input relative to a first heat generating component; the first heat generating component being upstream of a cooling element of the electronic device; receiving, from a temperature sensor disposed within an electronic device, temperature input relative to a second heat generating component; the second heat generating component being downstream of the cooling element; and controlling the cooling element to cool the first and second heat generating components based on both the temperature input relative to the first heat generating component and the temperature input relative to the second heat generating component. Other aspects are described and claimed.

Scaffolds For Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 125.-. (canceled)27. The device of claim 26 , wherein said device further comprises an extracellular matrix (ECM) component.28. The device of claim 26 , wherein the GM-CSF claim 26 , tumor antigen claim 26 , or immune response-promoting bioactive factor is covalently linked to said scaffold composition.29. The device of claim 26 , wherein the tumor antigen comprises a biopsy-extracted antigen or antigens.30. The device of claim 26 , wherein the tumor antigen comprises a tumor cell lysate.31. The device of claim 26 , wherein the scaffold composition comprises a biodegradable polymer.32. The device of claim 26 , wherein the scaffold composition degrades at a predetermined rate based on a physical parameter selected from the group consisting of temperature claim 26 , pH claim 26 , hydration status claim 26 , and porosity.33. The device of claim 26 , wherein said scaffold composition comprises pores of greater than 100 μm in size.34. The device of claim 26 , wherein the scaffold composition comprises pores of 400-500 μm in size.35. The device of claim 26 , wherein the tumor is chosen from a central nervous system (CNS) cancer claim 26 , CNS germ cell tumor claim 26 , lung cancer claim 26 , leukemia claim 26 , multiple myeloma claim 26 , renal cancer claim 26 , malignant glioma claim 26 , ovarian cancer claim 26 , prostate cancer claim 26 , medulloblastoma claim 26 , melanoma claim 26 , breast cancer claim 26 , ovarian cancer claim 26 , Karposi's sarcoma claim 26 , colon cancer claim 26 , adenocarcinoma claim 26 , brain cancer claim 26 , testicular cancer claim 26 , hepatocellular ...

Scaffolds For Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 125.-. (canceled)26. A cancer vaccine device comprising a scaffold composition comprising a polymer matrix and having open , interconnected macropores;a granulocyte-macrophage colony stimulating factor (GM-CSF) that recruits immune cells selected from macrophages, T-cells, B-cells, NK cells, and dendritic cells;a tumor antigen; andan immune response-promoting bioactive factor comprising a small molecule, wherein the GM-CSF, the tumor antigen, or the immune response-promoting bioactive factor is incorporated into or coated onto said scaffold composition.27. The device of claim 26 , wherein said device further comprises an extracellular matrix (ECM) component.28. The device of claim 26 , wherein the GM-CSF claim 26 , tumor antigen claim 26 , or immune response-promoting bioactive factor is covalently linked to said scaffold composition.29. The device of claim 26 , wherein the tumor antigen comprises a biopsy-extracted antigen or antigens.30. The device of claim 26 , wherein the tumor antigen comprises a tumor cell lysate.31. The device of claim 26 , wherein the scaffold composition comprises a biodegradable polymer.32. The device of claim 26 , wherein the scaffold composition degrades at a predetermined rate based on a physical parameter selected from the group consisting of temperature claim 26 , pH claim 26 , hydration status claim 26 , and porosity.33. The device of claim 26 , wherein said scaffold composition comprises pores of greater than 100 μm in size.34. The device of claim 26 , wherein the scaffold composition comprises pores of 400-500 μm in size.35. The device of claim 26 , ...

SOUNDING REFERENCE SIGNAL (SRS) TRANSMISSION IN MULTIPLE SRS SYMBOLS IN A SUBFRAME

Certain aspects of the present disclosure relate to techniques for sounding reference signal (SRS) transmission in multiple SRS symbols in a subframe based on multiple SRS configurations, including determining for each of the multiple symbols a SRS pattern index. In some examples, the present disclosure provides a method of wireless communication by a user equipment (UE). In certain aspects, the method includes receiving, from a base station, information corresponding to a plurality of SRS configurations for a subframe, and determining a plurality of symbols in the subframe for transmitting SRS based on the plurality of SRS configurations. 1. A method of wireless communication by a user equipment (UE) , comprising:receiving information corresponding to a plurality of sounding reference signal (SRS) configurations for a subframe;determining a plurality of symbols in the subframe for transmitting SRS based on the plurality of SRS configurations;determining, for each of the plurality of symbols, a SRS pattern index based on a function having a value equal to a number of the plurality of SRS configurations; andtransmitting SRS in each of the plurality of symbols based on the corresponding SRS pattern index.2. The method of claim 1 , wherein transmitting SRS in each of the plurality of symbols based on the corresponding SRS pattern index comprises claim 1 , for each of the plurality of symbols:determining at least one antenna or at least one antenna pair to use for transmitting the SRS based on the corresponding SRS pattern index; andtransmitting the SRS on the at least one antenna or at least one antenna pair in the symbol.3. The method of claim 1 , wherein transmitting SRS in each of the plurality of symbols based on the corresponding SRS pattern index comprises claim 1 , for each of the plurality of symbols:determining at least one frequency band to use for transmitting the SRS based on the corresponding SRS pattern index; andtransmitting the SRS on the at least one ...

Interfacing with multiple components connected to a printed circuit board

Apparatuses, systems, and methods for interfacing with multiple components connected to a printed circuit board. An apparatus includes a plurality of hardware components that each include a first interface. An apparatus includes a printed circuit board that includes a plurality of interfaces that communicatively couple each of the hardware components to the printed circuit board via the first interface. The printed circuit board includes a second interface that communicatively couples the printed circuit board to an information handling device and manages communications between the information handling device and each of the hardware components coupled to the printed circuit board.

SECURE DEVICE CHAMBER

For a secure device chamber, the device chamber is disposed in a chassis and includes a device port. A door latches to obstruct access to the device chamber. A logic circuit receives an uninterrupted power supply from a computer, stores a device access value, and unlatches the door in response to activation of a chamber eject button and a device access value not being a device secure mode. 1. An apparatus comprising:a device chamber disposed in a chassis and comprising a device port;a door that latches to obstruct access to the device chamber;a chamber eject button; anda logic circuit that receives an uninterrupted power supply from a computer, stores a device access value, and unlatches the door in response to activation of the chamber eject button and a device access value not being a device secure mode.2. The apparatus of claim 1 , wherein the logic circuit further unlatches the door in response to the activation of the chamber eject button claim 1 , the computer being one of off and in a standby mode claim 1 , and the device access value not being the device secure mode.3. The apparatus of claim 1 , wherein the logic circuit further unlatches the door in response to the activation of the chamber eject button claim 1 , the computer being on claim 1 , a screen not being locked claim 1 , and the device being unmounted.4. The apparatus of claim 1 , wherein the logic circuit does not unlatch the door in response to the computer being one of off and in a standby mode and the device access value being the device secure mode.5. The apparatus of claim 1 , wherein the logic circuit further unlatches the door in response to no device being mounted in the device port.6. The apparatus of claim 1 , wherein the device chamber and the door enclose a device mounted to the device port.7. The apparatus of claim 1 , wherein the device access value is set to a device released mode in response to a device being unmounted from the device port.8. The apparatus of claim 1 , the ...

SELECTIVELY TRANSMITTING SIGNALS

For selectively transmitting signals, a data lane interface communicates signals of at least one data lane of a serial bus. A video interface port receives a video display signal from a video card. A traffic circuit transmits the signals of the at least one data lane and the video display signal to a high-speed signal combiner in response to determining that the high-speed signal combiner is processing the signals of the at least one data lane and the video display signal for output as a combined video display signal. Else the traffic circuit transmits the video display signal to a video output port in response to determining that the high-speed signal combiner is not processing the signals of the at least one data lane and the video display signal for output as the combined video display signal. 1. An apparatus comprising:a data lane interface that communicates signals of at least one data lane of a serial bus;a video interface port that receives a video display signal from a video card; anda traffic circuit that transmits the signals of the at least one data lane and the video display signal to a high-speed signal combiner in response to determining that the high-speed signal combiner is processing the signals of the at least one data lane and the video display signal for output as a combined video display signal, else the traffic circuit transmits the video display signal to a video output port in response to determining that the high-speed signal combiner is not processing the signals of the at least one data lane and the video display signal for output as the combined video display signal.2. The apparatus of claim 1 , wherein the traffic circuit determines that the high-speed signal combiner is processing the signals of the at least one data lane and the video display signal for output by detecting serial bus traffic on the at least one data lane.3. The apparatus of claim 1 , wherein the traffic circuit determines that the high-speed signal combiner is ...

Controlled Delivery of TLR Agonists in Structural Polymeric Devices

The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents. 127.-. (canceled)28. A device comprising a polymeric structure composition , a tumor antigen , and a TLR3 agonist , wherein said TLR3 agonist comprises condensed polyinosine-polycytidylic acid (poly I:C) cationic nanoparticles , said condensed poly I:C cationic nanoparticles being formed by mixing said poly I:C with a polycation comprising positively charged amine groups at a charge ratio resulting in positively charged condensates and an average particle size of 98-545 nm.29. The device of claim 28 , further comprising a TLR9 agonist.30. The device of claim 28 , wherein said TLR3 agonist is present at a concentration effective to induce production of interleukin-12 (IL-12) by dendritic cells.31. The device of claim 28 , wherein when the device is implanted in a subject claim 28 , 200-400 ng/mL of IL-12 is produced at the site of implantation.32. The device of claim 28 , wherein the condensed poly (I:C) cationic nanoparticle comprises PEI-poly(I:C).33. The device of claim 29 , wherein the TLR9 agonist comprises a cytosine-guanosine oligonucleotide (CpG-ODN) or condensed CpG-ODN.34. The device of claim 28 , wherein the polymeric structure composition comprises poly-lactide-co-glycolide (PLG).35. The device of claim 29 , wherein the polymeric structure composition comprises poly-lactide-co-glycolide (PLG).36. The device of claim 28 , further comprising pathogen associated molecular patterns (PAMPs).37. The device of claim 29 , wherein the TLR9 agonist comprises a nucleic acid.38. The device of claim 37 , wherein the nucleic acid comprises a cytosine-guanosine oligonucleotide (CpG-ODN) or a PEI-CpG-ODN.39. The device of claim 28 , further comprising a recruitment composition.40. The device of claim 39 , wherein ...

COMBINATION VACCINE DEVICES AND METHODS OF KILLING CANCER CELLS

The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer. 178-. (canceled)79. A method of treating a poorly immunogenic cancer in a subject in need thereof comprising administering to the subject:a) an inhibitor of an immune checkpoint protein or ligand thereof; and (i) a macroporous scaffold composition comprising open, interconnected pores,', '(ii) a cell recruitment composition that recruits an immune cell, wherein the cell recruitment composition is selected from the group consisting of a cytokine, a chemokine, a growth factor, and a combination thereof; and', '(iii) an antigen derived from the cancer,, 'b) a device comprising'}thereby treating the cancer.80. The method of claim 79 , wherein the immune checkpoint protein or the ligand thereof is selected from the group consisting of cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) claim 79 , programmed cell death protein 1 (PD1) claim 79 , programmed cell death protein 1 ligand 1 (PDL1) claim 79 , programmed cell death protein ligand 2 (PDL2) claim 79 , lymphocyte activation gene 3 (LAG3) claim 79 , B7-H3 claim 79 , B7-H4 claim 79 , and T cell membrane protein 3 (TIM3) adenosine A2a receptor (A2aR) claim 79 , and kill inhibitory receptors (KIRs).81. The method of claim 79 , wherein the inhibitor of an immune checkpoint protein or ligand thereof is an antibody or an antigen binding fragment thereof.82. The method of claim 79 , wherein the inhibitor of an immune checkpoint protein is a protein that inhibits the interaction between the checkpoint protein and ligand thereof.83. The method of claim 81 , wherein the antibody is selected from the group consisting of BMS-936558 claim 81 , MK-3475 claim 81 , pidilizumab claim 81 , MDX1105 claim 81 , and MGA271.84. The method of claim 82 , wherein the protein that inhibits the interaction between the checkpoint protein and ...

Controlled Delivery of TLR Agonists in Structural Polymeric Devices

The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents. 1. A device comprising a porous polymeric structure composition , a disease-associated antigen , and a toll-like receptor (TLR) agonist , wherein said TLR agonist preferentially binds to TLR3.2. The device of claim 1 , wherein said disease-associated antigen comprises a tumor antigen.3. The device of claim 1 , wherein said polymeric structure composition comprises poly-lactide-co-glycolide (PLG).4. The device of claim 1 , wherein said TLR agonist comprises a TLR3 agonist.5. The device of claim 1 , wherein said TLR3 agonist comprises polyinosine-polycytidylic acid (poly I:C) or PEI-poly (I:C).6. The device of claim 1 , wherein said TLR agonist further comprises pathogen associated molecular patterns (PAMPs).7. The device of claim 1 , wherein said TLR agonist comprises a nucleic acid.8. The device of claim 1 , wherein said TLR agonist further comprises a TLR9 agonist.9. The device of claim 8 , wherein said TLR9 agonist comprises a cytosine-guanosine oligonucleotide (CpG-ODN) or a PEI-CpG-ODN.10. The device of claim 1 , wherein said device further comprises a recruitment composition.11. The device of claim 11 , wherein said recruitment composition comprises granulocyte macrophage colony stimulating factor (GM-CSF) claim 11 , Flt3L claim 11 , or CCL20.12. The device of claim 10 , wherein said recruitment composition comprises encapsulated GM-CSF.13. The device of claim 2 , wherein said tumor antigen comprises a tumor lysate claim 2 , purified protein tumor antigen claim 2 , or synthesized tumor antigen.14. The device of claim 6 , wherein said PAMPs comprises a monophosphoryl lipid A (MPLA).15. The device of claim 1 , wherein said device comprises a combination of TLR agonists claim 1 , said combination ...

Compounds For Use As Imaging Agents

The present invention describes the use of the Chinese medicinal compounds ginsenoside RB1, dihydromyricetin and salvianohc acid B, for use in diagnosing, monitoring and treating synucleinopathies, such as Parkinson's disease, in patients.

ANGLED DEVICE BAY CARD ASSEMBLY

A card assembly includes a card that includes a first edge and an opposing second edge, where the first edge includes an edge connector; and device sockets mounted to the card and operatively coupled to the edge connector, where each of the device sockets defines an end of a respective device bay, where each of the device bays is disposed at an angle of approximately 25 degrees to approximately 75 degrees with respect to the edge connector. 1. A card assembly comprising:a card that comprises a first edge and an opposing second edge, wherein the first edge comprises an edge connector; anddevice sockets mounted to the card and operatively coupled to the edge connector, wherein each of the device sockets defines an end of a respective device bay, wherein each of the device bays is disposed at an angle of approximately 25 degrees to approximately 75 degrees with respect to the edge connector, and wherein a dimension of the card between the first edge along the edge connector and the second edge is equal to or less than a maximum dimension of one of the device bays.2. The card assembly of comprising a device disposed in one of the device bays that is operatively coupled to the edge connector via a corresponding one of the device sockets.3. The card assembly of wherein an air flow clearance exists between the device and a surface of the card.4. The card assembly of comprising devices disposed in the device bays wherein each of the devices is operatively coupled to the edge connector via a corresponding one of the device sockets.5. The card assembly of wherein an air flow clearance exists between each of the devices and a surface of the card.6. The card assembly of wherein the card comprises opposing ends and wherein a line-of-sight exists in the air flow clearances along a direction between the opposing ends.7. The card assembly of wherein at least one of the device sockets is located closer to the first edge than the second edge.8. The card assembly of wherein the at ...

Substrate Design for Efficient Coupling Between a Package and a Dielectric Waveguide

A device includes a multilayer substrate having a first surface and a second surface opposite the first surface. An integrated circuit is mounted on the second surface of the multilayer substrate, the integrated circuit having transmission circuitry configured to process millimeter wave signals. A substrate waveguide having a substantially solid wall is formed within a portion of the multilayer substrate perpendicular to the first surface. The substrate waveguide has a first end with the wall having an edge exposed on the first surface of the multilayer substrate. A reflector is located in one of the layers of the substrate and is coupled to an edge of the wall on an opposite end of the substrate waveguide.

COMPUTER PORT CONTROL

A system can include a processor; memory operatively coupled to the processor; a chipset operatively coupled to the processor; ports where each of the ports includes a respective power supply line; a switch; a hub operatively coupled to the ports and to the chipset for data transfer via an in-band protocol; and a microcontroller operatively coupled to the chipset, to the switch and to the hub where the microcontroller includes circuitry that controls the switch to transfer data to one of the ports via an out-of-band protocol and where the microcontroller includes circuitry that controls supply of power to the power supply lines. 1. A system comprising:a processor;memory operatively coupled to the processor;a chipset operatively coupled to the processor;ports wherein each of the ports comprises a respective power supply line;a switch;a hub operatively coupled to the ports and to the chipset for data transfer via an in-band protocol; anda microcontroller operatively coupled to the chipset, to the switch and to the hub wherein the microcontroller comprises circuitry that controls the switch to transfer data to one of the ports via an out-of-band protocol and wherein the microcontroller comprises circuitry that controls supply of power to the power supply lines.2. The system of wherein the microcontroller comprises an embedded microcontroller of a super I/O.3. The system of comprising at least one power information bus.4. The system of wherein the at least one power information bus comprises a low power information bus and a high power information bus.5. The system of wherein the low power information bus provides current consumption information for one of the ports and wherein the high power information bus provides current consumption information for a different one of the ports.6. The system of comprising current consumption alert circuitry.7. The system of wherein the current consumption alert circuitry comprises a low power alert circuit and a high power alert ...

EMBEDDED MICROCONTROLLER AND BUSES

A system can include a power supply unit; a processor; memory operatively coupled to the processor; a chipset operatively coupled to the processor; diagnostic information memory; and a microcontroller operatively coupled to the chipset via a first diagnostic data transfer bus and the microcontroller operatively coupled to the power supply unit and to the diagnostic information memory via a second diagnostic data transfer bus. 1. A system comprising:a power supply unit;a processor;memory operatively coupled to the processor;a chipset operatively coupled to the processor;diagnostic information memory; anda microcontroller operatively coupled to the chipset via a first diagnostic data transfer bus and the microcontroller operatively coupled to the power supply unit and to the diagnostic information memory via a second diagnostic data transfer bus.2. The system of wherein the microcontroller comprises an embedded microcontroller of a super I/O.3. The system of wherein the second diagnostic data transfer bus comprises an I2C bus.4. The system of wherein the second diagnostic data transfer bus comprises a SMBus bus.5. The system of wherein the diagnostic information memory comprises EEPROM.6. The system of wherein the diagnostic information memory comprises flash memory.7. The system of further comprising a port hub operatively coupled to the diagnostic information memory.8. The system of wherein the second diagnostic data transfer bus operatively couples the port hub and the diagnostic information memory.9. The system of wherein the diagnostic information memory comprises diagnostic information based at least in part on a status of the power supply unit and based at least in part on a status of the processor.10. A method comprising:receiving diagnostic information via a diagnostic data transfer bus wherein the diagnostic information pertains to a power supply unit operatively coupled to the diagnostic data transfer bus;analyzing the diagnostic information to generate a ...

CIRCULARLY-POLARIZED DIELECTRIC WAVEGUIDE LAUNCH FOR MILLIMETER-WAVE DATA COMMUNICATION

A wave communication system includes an integrated circuit and a multilayered substrate. The multilayered substrate is electrically coupled to the integrated circuit. The multilayered substrate includes an antenna structure configured to transmit a circularly polarized wave in response to signals from the integrated circuit.

DOOR LOCKING DEVICE AND A SMART DOOR APPARATUS

A door locking device for a smart door apparatus () is provided comprising an interior door handle positionable on an interior side of a door; an exterior door handle positionable on an exterior side of the door (); a lock for the door () which is coupled to the interior door handle, the lock having a deadbolt which is activatable by actuation of the interior door handle; a controller for automatically generating an alert signal in the event of activation of the deadbolt; and a wireless communication module associated with the controller, the wireless communication module automatically transmitting the alert signal in the event of activation of the deadbolt. 1. A door locking device for a smart door apparatus , the door locking device comprising: an interior door handle positionable on an interior side of a door; an exterior door handle positionable on an exterior side of the door; a lock for the door which is coupled to the interior door handle , the lock having a deadbolt Which is activatable by actuation of the interior door handle; a controller for automatically generating an alert signal in the event of activation of the deadbolt; and a wireless communication module associated with the controller , the wireless communication module automatically transmitting the alert signal in the event of activation of the deadbolt.2. The door locking device as claimed in claim 1 , the controller further comprising a timing circuit claim 1 , the controller automatically disengaging the deadbolt after a predetermined duration defined by the timing circuit.3. The door locking device as claimed in claim 2 , wherein the predetermined duration is re-activatable upon repeated actuation of the interior door handle.4. The door locking device as claimed in claim 2 , further comprising at least one indicator element which is indicative of a remaining duration until disengagement of the deadbolt.5. The door locking device as claimed in claim 1 , wherein the activation of the deadbolt is ...

Scaffolds For Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 1. A cancer vaccine device comprising a scaffold composition comprising a polymer matrix and having open , interconnected macropores;a granulocyte-macrophage colony stimulating factor (GM-CSF) that recruits immune cells selected from macrophages, T-cells, B-cells, NK cells, and dendritic cells;a tumor antigen; andan immune response-promoting bioactive factor comprising an oligonucleotide, wherein the GM-CSF, the tumor antigen, or the immune response-promoting bioactive factor is incorporated into or coated onto said scaffold composition.2. The device of claim 1 , wherein said device further comprises an extracellular matrix (ECM) component.3. The device of claim 2 , wherein said ECM component comprises an arginine-glycine-aspartate (RGD) sequence.4. The device of claim 1 , wherein the GM-CSF claim 1 , tumor antigen claim 1 , or immune response-promoting bioactive factor is covalently linked to said scaffold composition.5. The device of claim 1 , wherein the tumor antigen comprises biopsy-extracted antigens.6. The device of claim 1 , wherein the tumor antigen comprises a tumor cell lysate.710-. (canceled)11. The device of claim 1 , wherein the scaffold composition degrades at a predetermined rate based on a physical parameter selected from the group consisting of temperature claim 1 , pH claim 1 , hydration status claim 1 , and porosity.12. (canceled)13. The device of claim 1 , wherein said scaffold composition comprises pores of greater than 100 μm in size.14. The device of claim 13 , wherein the scaffold composition comprises pores of 400-500 μm in size.1525-. (canceled)26. The ...

METHOD AND DEVICE FOR DUAL CODECS TO TRANSFER DIGITAL CONTENT

A method and device are provided. The electronic device includes a main circuit board that includes first and second edges and first and second sets of conductive traces. The device includes a memory to store program instructions. The processor, responsive to the program instructions, manages transfer of a digital content signal over the first and second sets of conductive traces. The device includes first and second codecs are coupled to the first and second edges, respectively. The first and second codecs are connected to the first and second sets of conductive traces, respectively. The first and second codecs convert the digital content signal into an analog content signal. The device includes first and second analog outputs coupled to the first and second codecs, respectively. The first and second analog outputs to output the analog content signal. 1. An electronic device , comprising:a main circuit board that includes first and second edges and first and second sets of conductive traces;memory to store program instructions;a processor located on the main circuit board, the processor, responsive to the program instructions, to manage transfer of a digital content signal over the first and second sets of conductive traces;first and second codecs coupled to the first and second edges, respectively, the first and second codecs connected to the first and second sets of conductive traces, respectively, the first and second codecs to convert the digital content signal into an analog content signal; andfirst and second analog outputs coupled to the first and second codecs, respectively, the first and second analog outputs to output the analog content signal.2. The device of claim 1 , wherein the first and second sets of conductive traces form non-cable digital interfaces to the first and second codecs.3. The device of claim 1 , wherein the first and second sets of conductive traces include edge contacts coupled to the first and second edges of the main circuit board ...

OPTICAL DETECTOR INCLUDING PLASMONIC METASURFACES AND BULK ACOUSTIC WAVE RESONATORS

An apparatus for an optical detector includes a bulk acoustic wave (BAW) resonator including a piezoelectric layer and a metal layer, an acoustic Bragg mirror on the BAW resonator and including a first acoustic impedance layer and a second acoustic impedance layer different than the first acoustic impedance layer, and a plasmonic metasurface on the acoustic Bragg mirror and including structures of geometric patterns arranged in an array. 1. An apparatus , comprising:a bulk acoustic wave (BAW) resonator including a piezoelectric layer and a metal layer;an acoustic Bragg mirror on the BAW resonator and including a first acoustic impedance layer and a second acoustic impedance layer different than the first acoustic impedance layer; anda plasmonic metasurface on the acoustic Bragg mirror and including structures of geometric patterns arranged in an array.2. The apparatus of claim 1 , wherein the plasmonic metasurface includes a grid of spaced gaps in a metal layer.3. The apparatus of claim 1 , wherein the structures of the plasmonic metasurface include an array of equally spaced metal patches on the acoustic Bragg mirror.4. The apparatus of claim 3 , wherein a size and a spacing of the equally spaced metal patches are configured to cause a peak in absorption of incident light at a particular frequency range.5. The apparatus of claim 1 , wherein the acoustic Bragg mirror includes multiple pairs of the first and second acoustic impedance layers in a stacked and alternating arrangement.6. The apparatus of claim 1 , wherein the metal layer is between a first metal layer and a second metal layer in the BAW resonator.7. The apparatus of claim 1 , further comprising first and second contacts on opposite sides of the BAW resonator.8. The apparatus of claim 7 , wherein each of the first contact and the second contact comprises respective extensions of the piezoelectric layer and the metal layer of the BAW resonator.9. The apparatus of claim 7 , wherein each of the first contact ...

Immune cell trapping devices and methods for making and using the same

Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or disease-specific cells. More specifically, the devices are useful for trapping immune cells and the devices contain a physiologically-compatible porous polymer scaffold, a plurality of antigens, and an immune cell-recruiting agent, wherein the plurality of antigens and the immune cell recruiting agent attract and trap the immune cell in the device. Also provided are pharmaceutical compositions, kits, and packages containing such devices. Additional embodiments relate to methods for making the devices, compositions, and kits/packages. Further embodiments relate to methods for using the devices, compositions, and/or kits in the diagnosis or therapy of diseases such as autoimmune diseases or cancers.

Process for producing alkaline treated cellulosic fibers

Systems and methods by which to subject cellulosic fibers to alkaline treatment are provided. The systems and methods of the invention include equipment, such as nanofiltration units and slurry concentrators, which result in a lowered overall consumption of alkaline solution during alkaline treatment. The systems and methods of the invention further allow the components of hemicaustic streams produced by such alkaline treatments to be utilized in higher value end uses.

Dual range capacitive MEMS force sensor for touch screen applications

A capacitive MEMS force sensor for touch recognition and force measurement in touch screens is provided. The sensor includes two planar conductive electrodes separated by a predetermined distance using an elastic spacer to define an initial capacitance value of the sensor. An applied external force deforms the elastic spacer and minimizes the gap between sensor electrodes to alter the nominal capacitance value. This change in capacitance is monitored to measure the magnitude of the touch force. The sensor includes two types of the elastic spacers with different values of stiffness to overcome the trade-off between sensitivity and dynamic range of force measurement. These elastic spacers are interposed between sensor electrodes and are offset with a height difference to provide two ranges of force measurement.

Separate customizable thermal control table

An apparatus, system, and method are disclosed for providing customized thermal control data structures. The default thermal control data structure is typically stored in a first storage device of the IOS module of the information processing system. A custom thermal control data structure is stored on a second storage device that is separately updatable from the first storage device. The thermal cooling module that provides cooling for the information processing system is directed to use the custom thermal control data structure for cooling components of the information processing system.

Wireless device with substrate to antenna coupling

A device comprises an integrated circuit (IC) die, a substrate, a printed circuit board (PCB), an antenna, and a waveguide stub. The IC die is affixed to the substrate, which comprises a signal launch on a surface of the substrate that is configured to emit or receive a signal. The substrate and the antenna are affixed to the PCB, such that the signal launch and a waveguide opening of the antenna are aligned and comprise a signal channel. The waveguide stub is arranged as a boundary around the signal channel. In some implementations, the waveguide stub has a height of λ/4, where λ represents a wavelength of the signal. In some implementations, the antenna includes the waveguide stub; in others, the substrate includes the waveguide stub.

Scaffolds for cell transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

Scaffolds for cell collection or elimination

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host.

Scaffolds for cell transplantation

Packaged electronic device and multilevel lead frame coupler

A packaged electronic device includes a multilayer lead frame having first and second trace levels, a via level therebetween, a conductive feed structure, and a conductive reflector wall. The first trace level includes a conductive coupler antenna and a conductive ground structure that extends in a plane of orthogonal first and second directions, and a portion of the conductive coupler antenna faces outward along a third direction orthogonal to the first and second directions. The conductive reflector wall has an opening and extends along the third direction between the first and second trace levels around a portion of the conductive coupler antenna. The conductive feed structure is coupled to the conductive coupler antenna and extends along the first direction through the opening of the conductive reflector wall.

Circularly-polarized dielectric waveguide launch

Scaffolds for Cell Transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material. 10086947_1 (GHMattes) P77900.AU.3

Immune cell trapping devices and methods for making and using the same

Techniques for controlling hybrid automatic repeat request (HARQ)

Methods, systems, and devices for wireless communications are described. A user equipment (UE) may adaptively switch between hybrid automatic repeat request (HARQ) monitoring modes to support power savings. In a first HARQ skipping mode, the UE may transmit an uplink message corresponding to a HARQ identifier and may receive a positive acknowledgment (ACK) message in a HARQ monitoring occasion associated with the HARQ identifier. Upon receiving the ACK message, the UE refrains from monitoring a subsequent HARQ monitoring occasion associated with the HARQ identifier while in the first HARQ skipping mode (e.g., an aggressive HARQ skipping mode). The UE may periodically enter a periodic evaluation mode from the first HARQ skipping mode, in which the UE monitors a subsequent HARQ monitoring occasion after receiving an ACK message to check for false ACK messages. If a false ACK message is detected, the UE enters a first HARQ skipping prohibited mode.

Method of diagnosing a broken bar fault in an induction motor

A method for diagnosing induction motor broken bar faults using the resultant magnetic field pendulous oscillation phenomenon is disclosed. Broken bar faults cause the resultant magnetic field of an induction motor to possess a pendulous oscillation modulating its inherent rotation at synchronous speed, and the range of this angular pendulous oscillation, referred to as the swing angle, increases with an increase in the number of broken bars. The angular pendulous oscillation is determined by calculating the space vectors derived from motor terminal voltages and currents. The variation in the angular difference between these two space vectors versus time is used to observe the resultant magnetic field's pendulous oscillation, and thus provide on-line rotor fault diagnostics.

Average consistency-brightness enhancement with ozone of high-consistency-ozone bleached mass

Treatment using heterodimeric relaxin fusions

The present invention relates to uses of heterodimeric Relaxin fusion polypeptides, in particular for the treatment of heart failure with pulmonary hypertension.

Scaffolds for cell transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

Scaffolds for cell transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

Biomaterials for modulating immune responses

The provided herein are methods and compositions for eliciting an immune response to an antigen, such as cancer and microbial antigens.

Scaffolds for cell transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

Transport block size for channels with shortened transmission time interval

Systems, apparatuses, and methods for computing transport block size (TBS) for channels with shortened transmission time interval (sTTI). An initial size may be determined based on one or more TBS tables. The initial size may be scaled by a factor associated with an sTTI channel. A TBS table is selected based on the one or more TBS tables. The scaled size may be rounded based on the selected TBS table to generate a TBS for the sTTI channel.

Mouth and transmitter or ear and receiver contacts avoiding device i.e. protective cover, for e.g. portable telephone, has recess housing clip when clip is folded and projections forming space between case and microphone

The device has a case including a lid (1) and a container (3) containing a deodarant and disinfectant filter, where the container has a clip (6) articulated between wings of a hinge. The clip has a hook (7) with ends (7a) bent towards the interior. The ends hold a median part (M) of a private telephone handset i.e. portable telephone, when the clip is deployed during utilization of the device. A recess houses the clip when the clip is folded during non-usage or storing of the device. Projections form a space between the case and a microphone for pure sound.

Scaffolds for cell transplantation

A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material.

WIRELESS DEVICE WITH SUBSTRATE-TO-ANTENNA COUPLING

Ein Gerät umfasst einen Chip mit integrierter Schaltung (Integrated Circuit - IC) (205), ein Substrat (210), eine Leiterplatine (Printed Circuit Board - PCB) (250), eine Antenne (260) und eine Wellenleiterstichleitung(270A). Der IC-Chip ist an dem Substrat befestigt, das eine Signaleinkopplung (220A) auf einer Oberfläche des Substrats umfasst, die dazu ausgelegt ist, ein Signal auszusenden oder zu empfangen; Das Substrat und die Antenne sind an dem PCB befestigt, sodass die Signaleinkopplung und eine Wellenleiteröffnung der Antenne ausgerichtet sind, und einen Signalkanal (230A) umfassen. Die Wellenleiterstichleitung ist als eine Begrenzung um den Signalkanal herum angeordnet. In einigen Implementierungen hat die Wellenleiterstichleitung eine Höhe von λ/4, wobei λ eine Wellenlänge des Signals darstellt. In einigen Implementierungen beinhaltet die Antenne die Wellenleiterstichleitung; in anderen beinhaltet das Substrat die Wellenleiterstichleitung. A device includes an integrated circuit (IC) chip (205), a substrate (210), a printed circuit board (PCB) (250), an antenna (260), and a waveguide stub (270A). The IC chip is attached to the substrate comprising a signal launch (220A) on a surface of the substrate adapted to transmit or receive a signal; The substrate and antenna are attached to the PCB such that the signal launch and a waveguide aperture of the antenna are aligned and include a signal channel (230A). The waveguide stub is placed as a boundary around the signal channel. In some implementations, the waveguide stub has a height of λ/4, where λ represents a wavelength of the signal. In some implementations, the antenna includes the waveguide stub; in others, the substrate includes the waveguide stub.

Process for producing alkaline treated cellulosic fibers

Demodulation and csf for 8rx antennas

A method for wireless communication at a wireless device is disclosed herein. The method includes selecting a wideband precoder for a first set of antennas and a second set of antennas based on at least one matrix, where a number of the first set of antennas and the second set of antennas is greater than a maximum number of supported layers. The method includes calculating, based on the selected wideband precoder, a first set of performance metrics for the first set of antennas and a second set of performance metrics for the second set of antennas. The method includes combining the first set of performance metrics for the first set of antennas and the second set of performance metrics for the second set of antennas based on the calculation.

Biomaterials for modulating immune responses

Compact high-performance device-integrated antennas

An antenna integrated in a device package is formed such that at least a portion of the antenna is elevated with respect to a substrate of the device package. The entire antenna and its functionality are positioned within a space extending vertically upwardly from a footprint of the substrate that contains circuitry of the device. The boundary of the space is defined by the perimeter of an over mold positioned on the substrate and encapsulating the circuitry.

Compounds for use as imaging agents

The present invention describes the use of the Chinese medicinal compounds ginsenoside RB1, dihydromyricetin and salvianohc acid B, for use in diagnosing, monitoring and treating synucleinopathies, such as Parkinson's disease, in patients.

Compounds for use as imaging agents

The present invention describes the use of the Chinese medicinal compounds, ginsenoside Rb1, dihydromyricetin, and salvianolic acid B as imaging agents, for use in diagnosing and monitoring synucleinopathies, such as Parkinson's disease in patients

Dihydromyricetin for use as imaging agent

Compounds for use as imaging agents

Methods and apparatus to detect infrared wavelengths using a mechanical resonator with an integrated plasmonic infrared absorber

An example apparatus includes: a semiconductor substrate; a mechanical resonator supported by the substrate, the mechanical resonator including an array of capacitors; and a plasmonic infrared (IR) absorber including an array of metal structures. The mechanical resonator is between the substrate and the IR absorber.

Compositions, methods, and systems for carbon capture

Described herein are methods for capturing an acidic gas from a gas stream. The method can include contacting the gas stream with a capture solution including a gas capture agent and a surfactant. In some embodiments, the method can include contacting the gas stream with a capture solution including a surface-active gas capture agent.

Computer-implemented method of liver resection planning

The invention relates to a computer-implemented method of liver resection surgery planning, comprising the steps of:- processing (E2) preoperative computed tomographic images (10) of a patient to generate liver, liver lesion(ss) and venous vessels segmentations;- pruning the venous vessels segmentation to retain only major vessels and determining (E3) a primary hepatic zone (PHZ) from the retained major vessels;- determining (E4) at least one quantitative feature from the primary hepatic zone, the liver segmentation and the liver lesion(s) segmentation;- processing (E5) the determined quantitative features with a classification model to determine a liver resection complexity score for the patient.

Compact high-performance device-integrated antennas

An antenna integrated in a device package is formed such that at least a portion of the antenna is elevated with respect to a substrate of the device package. The entire antenna and its functionality are positioned within a space extending vertically upwardly from a footprint of the substrate that contains circuitry of the device. The boundary of the space is defined by the perimeter of an over mold positioned on the substrate and encapsulating the circuitry.

Systems and methods for capturing, transporting, and reproducing three-dimensional simulations as interactive volumetric displays

A system, method, and device are provided for creating a data processing pipeline to capture, transport, and interactively display in both recorded and real time any 3D volumetric simulation that was generated by a separate application. The system, method, and device enabling the interactive viewing of virtual and mixed reality simulations by a plurality of users.

Detection of displayport alternate mode communication

Detection of DISPLAYPORT alternate mode communication and connector plug orientation without use of a power distribution controller

This disclosure generally relates to USB TYPE-C, and, in particular, DISPLAYPORT Alternate Mode communication in a USB TYPE-C environment. In one embodiment, a device determines a DISPLAYPORT mode and determines an orientation of a USB TYPE-C connector plug. A multiplexer multiplexes a DISPLAYPORT transmission based in part on the determined orientation of the USB TYPE-C connector plug.

Detection of displayport alternate mode communication

This disclosure generally relates to USB Type-C, and, in particular, DisplayPort Alternate Mode communication in a USB Type-C environment. In one embodiment, a device (110) determines a DisplayPort mode and determines an orientation of a USB Type-C connector plug (120). A multiplexer (142a) multiplexes a DisplayPort transmission based in part on the determined orientation of the USB Type-C connector plug (120).