Application of inhibiting MST1/2 or knocking out MST1/2 in macrophage in treatment of polymyxin drug-resistant bacterial disease

The invention relates to the technical field of medicines, in particular to application of inhibiting MST1/2 or knocking out MST1/2 in macrophages in treatment of polymyxin drug-resistant bacterial diseases. According to the application disclosed by the invention, in escherichia coli infected mice carrying transferable polymyxin gene (mcr)-3, the survival rate of the mice can be obviously improved by injecting the MST1/2 inhibitor XMU-MP-1 into the abdominal cavity; in addition, by inhibiting MST1/2 or knocking out MST1/2 in macrophages, the tissue bacterium loading amount of the mouse can be remarkably reduced, and the inflammatory response level of the mouse is improved; the application of the MST1/2 inhibitor or the knockout of MST1/2 in macrophages to the treatment of related diseases infected by mcr-3 escherichia coli can effectively improve the inflammatory response level of mice and promote the removal of mcr-3 escherichia coli in vivo; the invention provides a brand new choice and ...