24-10-2013 дата публикации
Номер: US20130280185A1
Described herein are compounds of Formula (I): or a salt thereof; wherein: R1 and R5 are independently selected from H, OH and alkoxy; R-Rand R-Rare independently selected from H, OH, F, Cl, Br, and I; Rand Rare independently selected from H, alkyl, alkenyl, alkynyl, and aryl; with the proviso that: at least one of R and Ris OH or alkoxy; and at least one of CR-Rand R-Ris F, Cl, Br or I; compositions comprising said compounds; and methods of making and using the same. 2. The compound of claim 1 , wherein:{'sub': 1', '5, 'Rand Rare independently selected from OH or alkoxy; and'}{'sub': 2', '6, 'Rand Rare independently selected from H, F, Cl, Br and I.'}3. The compound of claim 1 , wherein Rand Rare OH.4. The compound of claim 1 , wherein Rand Rare OH.7. A composition comprising the compound of ; and a carrier.8. The composition of claim 7 , wherein the carrier is an orally acceptable carrier.9. The composition of claim 7 , wherein the compound of Formula (I) is present at a concentration of from about 0 claim 7 ,01 to about 1% claim 7 , by weight.10. The composition of claim 7 , wherein the compound of Formula (I) is present at a concentration of from about 0.1 to about 0.75% claim 7 , by weight.11. The composition of claim 7 , wherein the compound of Formula (I) is present at a concentration of about 0.5% claim 7 , weight.12. The composition of claim 7 , further comprising one or more components selected from a fluoride ion source; a tartar control agent; a buffering agent; an abrasive; and a combination of two or more thereof.13. The composition of claim 12 , wherein at least one of the one or more components is a fluoride ion source selected from: stannous fluoride claim 12 , sodium fluoride claim 12 , potassium fluoride claim 12 , sodium monofluorophosphate claim 12 , sodium fluorosilicate claim 12 , ammonium fluorosilicate claim 12 , amine fluoride claim 12 , ammonium fluoride claim 12 , and a combination of two or more thereof.14. A method of treating or ...
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