Bio-artificial substrate for the production of animal and, in particular, human tissues and organs

PROCEDURE FOR THE PRODUCTION OF SEIDENFIBROINVLIESSTOFFEN

Method for the preparation of a non-woven silk fibroin fabrics

Method for the preparation of a non-woven silk fibroin fabrics

A process for producing non-woven silk fiber fabrics comprises the following steps: a) obtaining silk fibroin, for example either from silk cocoons, or silk textiles or waste silk; b) removing the sercin layer covering the silk fibroin fibers, when present; c) breaking the disulfide bonds between heavy (350 kDa) and light (27 kDa) chains of silk fibroin in order to obtain the production of chain fragments which serve as a specific cellular recognition sites promoting the attachment and growth of cells, d) homogenising of the material resulting from step c).

VERFAHREN ZUR HERSTELLUNG VON SEIDENFIBROINVLIESSTOFFEN

VERFAHREN ZUR HERSTELLUNG VON SEIDENFIBROINVLIESSTOFFEN

PROCEDURE FOR THE PREPARATION OF A NON-WOVEN FABRIC IN SILK FIBER.

Use of calcilytic drugs as a pharmacological approach to the treatment and prevention of alzheimer's disease, alzheimer's disease-related disorders, and down's syndrome neuropathies

A pharmacological treatment of both familial early onset and sporadic late onset Alzheimer's disease (AD), AD-related disorders and Down's syndrome-coupled neuropathies involves the use of a class of drugs, the calcilytics, which by inhibiting the calcium-sensing receptor (CaSR)signaling in all types of brain cells prevent: (i) the overproduction of cell-harming nitric oxide (NO) and peroxynitrite (ONOO - ), and most importantly (ii) the intracellular overproduction, accumulation, and secretion of Amyloid β (Aβ) peptides in response to the extracellular presence of exogenous Aβpeptides and/or proinflammatory cytokines, and (iii) the Aβ peptide-related hyperphosphorylation of the Tau (τ) protein on the part of an Aβ/Ca SR-signaling activated glycogen synthase kinase-(GSK)-3β w i t h the resulting formation of neurofibrillary tangles (NTFs), the latter known to cause such severe dysfunctioning of the microtubular cytoskeleton as to eventually favor (iv) the death of human cerebral cortex neurons.

Verfahren zur herstellung von seidenfibroinvliesstoffen

Procedimento per la preparazione di un tessuto non tessuto in fibroina di seta