Enumeration of rooted partial subtrees

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for enumerating rooted partial subtrees are disclosed.

Multi-Piece Shield

This disclosure relates to a multi-piece shield comprising a fence, a lid, and an insert. The lid attaches to the fence, which is attached to the circuit board. The lid is a relatively thick, flexible material for supporting the insert. The lid has a recess so that the insert can be recessed into the lid to position the insert closer to the circuit for enhanced heat absorption. The insert is made of a thicker heat absorbing material than the lid, again to facilitate heat absorption. The insert can be press-fit into the recess of the lid. The lid can have a dovetail configuration to retain the insert in the lid. 1. A multi-piece electromagnetic radiation and heat dissipation shield for electrical components , comprising:a fence having sidewalls forming an enclosure surrounding electrical components;a lid having a top wall, an interior wall depending from the top wall and defining a recess, a shelf extending from the interior wall and offset from the top wall, the shelf having an inner edge defining an aperture, and a plurality of depending fingers about an outer periphery of the lid, the plurality of depending fingers engaging the sidewalls of the fence; andan insert having a perimeter sized and shaped to be received within the recess and on the shelf.2. The multi-piece shield of claim 1 , wherein the shelf extends parallel to the top wall of the lid.3. The multi-piece shield of claim 1 , wherein a bottom surface of the insert contacts a top surface of the shelf of the lid.4. The multi-piece shield of claim 1 , wherein the insert is press-fit into the lid.5. The multi-piece shield of claim 4 , wherein the insert has an outer edge that frictionally engages the interior wall of the lid.6. The multi-piece shield of claim 1 , wherein the insert is directly exposed to the electrical components through the aperture of the lid.7. The multi-piece shield of claim 1 , wherein a top surface of the insert is coplanar with the top wall of the lid.8. The multi-piece shield of ...

Tracking data usage in wireless networks

A method may include determining a number of user devices that can access data services in a wireless network and storing information identifying the determined number of user devices for each of a number of sectors for each of a number of periods of time. The method may also include receiving a request from a first user device associated with a first user for access to data services during a first period of time, accessing the stored information to determine whether to grant the request and providing access to data services via the wireless network to the first user device. The method may further include excluding data usage by the first user device during the first period of time from being applied against a data limit associated with the user's data plan.

Grounding Spacer

A grounding spacer is provided. The grounding spacer comprising a circular body having a top surface, a bottom surface, and a central aperture, and a plurality of radially spaced penetration features, wherein at least one of the penetration features has at least a portion thereof extending from the top surface, and wherein at least one of the penetration features has at least a portion thereof extending from the bottom surface. 1. A solar panel assembly comprising:a mounting rail for a solar panel;a solar panel mounted to the mounting rail and having an extruded frame; andone or more grounding spacers in mechanical and electrical contact with the mounting rail and the solar panel, each grounding spacer having a body with a top surface and a bottom surface, and a plurality of apertures with upstanding and depending rims, wherein at least one of the plurality of apertures has at least a portion thereof upstanding from the top surface, and a portion thereof depending from the bottom surface.2. The solar panel assembly of claim 1 , wherein the grounding spacer comprises a single sheet.3. The solar panel assembly of claim 1 , wherein the plurality of apertures each have rims that alternatingly extend in opposite directions.4. The solar panel assembly of claim 1 , wherein each of the apertures have rims partially about the aperture that extend in opposite directions.5. The solar panel assembly of claim 1 , wherein the grounding spacers penetrate the solar panel frame and the mounting rail claim 1 , thereby providing grounding contact between them. This application is a divisional of, and claims the benefit of priority to, U.S. Patent Application No. U.S. patent application Ser. No. 14/209,299 filed on Mar. 13, 2014, which claims priority to U.S. Provisional Patent Application No. 61/784,847 filed on Mar. 14, 2013, the entire disclosures of which are expressly incorporated herein by reference.Field of the DisclosureThe present disclosure relates generally to grounding ...

METHODS FOR PRODUCING A CELLULOSIC FIBER HAVING A HIGH CURL INDEX AND ACQUISITION AND DISTRIBUTION LAYER CONTAINING SAME

A process for producing cellulosic fiber with a high curl index is disclosed. The process can include mechanically treating and chemically crosslinking kraft pulp. The mechanical treatment of the pulp can include convolving and mechanically treating a pulp at in a plug screw and steam tube at temperatures above 100° C. and pressures above 3 bar. The mechanically treated pulp can be crosslinked with a crosslinking agent. The product fiber can exhibit a curl index of greater than 0.35, and can be at least 50% higher than the initial curl of the starting pulp material. 1. A process for preparing a high-curl kraft pulp , comprising passing pulp through a plug screw', 'passing the pulp through a steam tube in less than about 6 minutes;', 'pressurizing the pulp while in the plug screw with steam at a temperature above 100° C. and a pressure greater than 2 bar;, 'mechanically treating a chemical pulp by'}treating the mechanically processed kraft pulp with a crosslinking agent;drying the processed kraft pulp at a temperature above 100° C.; andcuring the processed kraft pulp at a temperature of at least about 140° C. to produce the high-curl pulp.2. The process of claim 1 , wherein the pulp is at a pressure greater than 3 bar.3. The process of claim 1 , wherein the pulp is at a pressure of 3 to 5 bar.4. The process of claim 1 , wherein the pulp resides in the steam tube for 30 seconds to 5 minutes.5. The process of claim 1 , wherein the pulp resides in the steam tube for about 30 seconds to 4 minutes.6. The process of claim 1 , wherein the pulp resides in the steam tube for about 2 to 4 minutes.7. The process of claim 1 , wherein the pulp is at a pressure of 3-5 bars at a temperature greater than 100° C. for 30 seconds to 4 minutes.8. The process of claim 1 , wherein the crosslinking agent is selected from the group consisting of critic acid and glutaraldehyde.9. The process of claim 1 , wherein the crosslinking agent is 0.5% to 10% by weight to the kraft pulp solids.10. The ...

Grounding spacer

A grounding spacer is provided. The grounding spacer comprising a circular body having a top surface, a bottom surface, and a central aperture, and a plurality of radially spaced penetration features, wherein at least one of the penetration features has at least a portion thereof extending from the top surface, and wherein at least one of the penetration features has at least a portion thereof extending from the bottom surface.

Multi-piece shield

This disclosure relates to a multi-piece shield comprising a fence, a lid, and an insert. The lid attaches to the fence, which is attached to the circuit board. The lid is a relatively thick, flexible material for supporting the insert. The lid has a recess so that the insert can be recessed into the lid to position the insert closer to the circuit for enhanced heat absorption. The insert is made of a thicker heat absorbing material than the lid, again to facilitate heat absorption. The insert can be press-fit into the recess of the lid. The lid can have a dovetail configuration to retain the insert in the lid.

Enumeration of trees from finite number of nodes

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed.

Grounding Spacer

A grounding spacer is provided. The grounding spacer comprising a circular body having a top surface, a bottom surface, and a central aperture, and a plurality of radially spaced penetration features, wherein at least one of the penetration features has at least a portion thereof extending from the top surface, and wherein at least one of the penetration features has at least a portion thereof extending from the bottom surface. 1. A grounding spacer comprising:a body having a top surface, a bottom surface, and a central aperture; anda plurality of apertures extending through the body;a rim extending about each of the plurality of apertures, wherein at least one of the rims is upstanding from the top surface and at least one of the rims is depending from the top surface.2. The grounding spacer of claim 1 , wherein the grounding spacer is of a single sheet construction.3. The grounding spacer of claim 1 , wherein the apertures are round.4. The grounding spacer of claim 1 , wherein the apertures are elongate.5. The grounding spacer of claim 1 , wherein each of the plurality of apertures has rims alternatingly extending in opposite directions.6. The grounding spacer of claim 4 , wherein each of the plurality of apertures has an upstanding rim portion and a depending rim portion.7. The grounding spacer of claim 6 , wherein the upstanding and depending rims are side by side around an aperture.8. The grounding spacer of claim 6 , wherein the upstanding and depending rims are separated by an inner and outer arcs. This application is a divisional of, and claims the benefit of priority to, U.S. patent application Ser. No. 14/209,299 filed on Mar. 13, 2014, which claims priority to U.S. Provisional Patent Application No. 61/784,847 filed on Mar. 14, 2013, the entire disclosures of which are expressly incorporated herein by reference.Field of the DisclosureThe present disclosure relates generally to grounding spacers for making electrical connection between metal pieces that ...

ENUMERATION OF ROOTED PARTIAL SUBTREES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for enumerating rooted partial subtrees are disclosed. 156-. (canceled)57. A method of executing computer instructions on at least one computing device in which the at least one computing device includes at least one processor and at least one memory , the method comprising:executing the computer instructions on the at least one processor of the at least one computing device;wherein the computer instructions to be executed comprise instructions for query processing; representing a query as a numeral;', 'comparing the query numeral with one or more numerals representing rooted partial subtrees of a complex tree hierarchy for a set of electronic documents; and', 'storing the result of the comparison in the at least one memory of the at least one computing device;, 'wherein the executing the query processing instructions comprise enumerating a set of rooted partial subtrees for the complex tree hierarchy, wherein the set of rooted partial subtrees comprises at least one rooted partial subtree having a same node as a second rooted partial subtree;', 'determining one or more digital signals for numerals associated with the enumerated rooted partial subtrees of the set; and, 'wherein the executing the query processing instructions further comprisereturning one or more corresponding rooted partial subtrees of the set based, at least in part, on the comparison.58. The method of claim 57 , wherein the executing the query processing instructions further comprises:identifying one or more subtrees coupled to a root node of the complex tree hierarchy; andenumerating a set of rooted partial subtrees of the identified subtrees.59. The method of claim 58 , wherein the executing the query processing instructions further comprises: merging combinations of individual ones of the enumerated rooted partial ...

ENUMERATION OF TREES FROM FINITE NUMBER OF NODES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. 1. A method of enumerating possible complex two-dimensional graphical hierarchies for more convenience processing and/or storage , a complex two-dimensional graphical hierarchy being in the form of a tree hierarchy , the method comprising:enumerating possible tree hierarchies, in which a tree hierarchy comprises one or more signal values, configurable from a finite number (N) of nodes;determining for the enumerated tree hierarchies natural numerals associated with particular ones of the enumerated tree hierarchies;storing, in a memory, the natural numerals.219-. (canceled)20. The method of claim 1 , the method further comprising:identifying N−1 arrangements of subtree hierarchy slots coupled to a root node; determining one or more allocations of N−1 nodes among the subtree hierarchy slots in the arrangement, a subtree hierarchy slot being allocated a portion of the N−1 nodes; and', 'for the subtree hierarchy slots, enumerating one or more possible subtree hierarchies configurable from the portion of the N−1 nodes allocated to the subtree hierarchy slot., 'for an arrangement of subtree hierarchy slots21. The method of claim 20 , the method further comprising:associating the enumerated one or more possible subtree hierarchies for a subtree hierarchy slot with a natural numeral; anddetermining the natural numeral associated with a tree hierarchy enumerated from an allocation of the N−1 nodes among subtree hierarchies based, at least in part, upon a combination of the natural numerals associated with particular subtree hierarchies enumerated from the allocation of N−1 nodes.22. The method of claim 21 , wherein the natural numeral associated with a tree hierarchy enumerated from an allocation of the N−1 nodes is based claim 21 , at least in part claim 21 , upon a product of the natural numerals associated with the particular subtree hierarchies enumerated ...

Tracking data usage in wireless networks

A method may include determining a number of user devices that can access data services in a wireless network and storing information identifying the determined number of user devices for each of a number of sectors for each of a number of periods of time. The method may also include receiving a request from a first user device associated with a first user for access to data services during a first period of time, accessing the stored information to determine whether to grant the request and providing access to data services via the wireless network to the first user device. The method may further include excluding data usage by the first user device during the first period of time from being applied against a data limit associated with the user's data plan.

ENUMERATION OF ROOTED PARTIAL SUBTREES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for enumerating rooted partial subtrees are disclosed. 156-. (canceled)57. A method of executing instructions on at least one computing device in which the at least one computing device includes at least one processor and at least one memory , the method comprising:communicating instructions from the at least one memory to the at least one processor; andexecuting the communicated instructions on the at least one processor of the at least one computing device;wherein the communicated instructions comprise instructions to manipulate a set of states stored as a hierarchical set; andwherein the executing the manipulation instructions further comprise:representing the hierarchical set of stored states, at least in part, as a complex tree hierarchy, wherein the complex tree hierarchy comprises a set of rooted partial subtrees, and wherein the rooted partial subtrees represent at least a portion of the states in the complex tree hierarchy;associating numerals with respect to respective rooted partial subtrees in the set of rooted partial substrees; andperforming one or more operations on the hierarchical set of stored states.58. The method of claim 57 , wherein the performing an operation on the hierarchical set of stored states comprises performing one or more arithmetic operations on at least some of the numerals associated with the respective rooted partial subtrees.59. The method of wherein the executing the manipulation instructions further comprises:associating numerals with respective rooted partial subtrees, wherein the associating numerals with respective rooted partial subtrees comprises providing relationships between the respective rooted partial subtrees.60. The method of claim 59 , wherein the performing one or more operations on the hierarchical set of stored states is based claim 59 ...

Enumeration of trees from finite number of nodes

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed.

Nitroimidazooxazines and their uses in anti-tubercular therapy

The present invention relates to novel nitroimidazooxazines, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.

Resettable drug delivery device

A drive member for driving a piston rod in a drug delivery device is provided. The drive member is configured to be driven in a rotational movement by an actuating member. The drive member comprises a track for transmitting a driving load from the actuating member to the drive member. The track comprises both sections running in a distal and sections running in a proximal direction of the drive member. Moreover, a drug delivery device comprising such a drive member is provided.

Dispensing device

A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

ENUMERATION OF ROOTED PARTIAL SUBTREES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for enumerating rooted partial subtrees are disclosed. 1. A method comprising:enumerating possible component rooted partial subtrees of a tree; anddetermining natural numerals associated with particular ones of said enumerated rooted partial subtrees, said natural numerals being based, at least in part, on an association between trees and natural numerals.2. The method of claim 1 , wherein said enumerating possible component rooted partial subtrees of said tree further comprises:identifying one more subtrees coupled to a root node of said tree; andenumerating possible component rooted partial subtrees of said identified subtrees.3. The method of claim 2 , wherein said enumerating possible component rooted partial subtrees of said tree further comprises merging combinations of individual ones of said enumerated possible component rooted partial subtrees of said identified subtrees.4. The method of claim 2 , wherein said tree is represented as a composite natural numeral based claim 2 , at least in part claim 2 , on said association claim 2 , and wherein identifying said one or more subtrees further comprises factoring said composite natural numeral into natural numerals representative of subtrees.5. The method of claim 4 , wherein said enumerating possible component rooted partial subtrees of said identified subtrees further comprises:associating said one or more subtrees with one or more non-composite natural numerals based, at least in part, on said association;performing an inverse push operation on the non-composite natural numerals to provide one or more natural numerals representative of one or more child trees of said identified subtrees; andenumerating one or more rooted partial subtrees of said one or more child trees based, at least in part, on said one or more natural numerals ...

One-Piece Board Level Shielding With Peel-Away Feature

A one-piece board level shielding element with a top cover peel panel is secured to a circuit board to shield and provide access to a shielded component. The shielding element is formed with a top having a peel line to facilitate removal of the peel panel with a peel tool. Once the repair is completed, a new cover is put on to the remaining side-walls to reestablish the shielding. The shield top cover is formed with a peel tool insertion slot and an adjacent peel start slot. The peel panel is removed by a peel tool having a peel hook mounted to a cylindrical peel key that is inserted into the insertion slot and hooks the cover at the peel start slot. Upon rotating the peel key away from the peel start slot, the peel panel is easily removed. A fixture plate may be used to support the peel tool and assist in removal of the peel panel 1. A peel key , comprising an elongated cylindrical key;an elongated member having a peel hook at the distal end and mounted to the peel key;the peel hook having a tip pointed towards the peel key.2. The peel key of claim 1 , including at least one pin hole for receiving a pin to assist rotation of the peel key.3. A method to remove a peel panel from a shielding element and restore shielding; comprising:providing a one-piece board level shielding element having a substantially planar top cover having at least three sides dimensioned to cover an element to be shielded and having a preformed peel line corresponding to the perimeter of the top cover to define a peel panel and allow for removal of the peel panel, the top cover extending to a side wall integral with the cover and extending at about a 90° angle outside the peel line to form a substantially vertical side walls adapted to be mounted to the circuit substrate;the cover including a peel tool insertion slot adjacent an intersection formed by two adjacent sides of the cover and inside the preformed peel line;placing a substantially planar fixture plate having a central opening having ...

Dendritic Cell Marker and Uses Thereof

The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind these proteins. These compounds can be used to detect and/or enrich a subset of dendritic cells or precursors thereof. These compounds can also be used to target antigens to dendritic cells or precursors thereof to modulate a humoral and/or T cell mediated immune response to an antigen, or used to target cytotoxic agents to dendritic cells or precursors thereof involved in diseased states.

Automated Beverage Dispensing System with Vertical Staging

The present application provides an automated beverage dispenser for use with a number of cups. The automated beverage dispenser may include a carousel with a number of shelves, a first actuator such that first actuator may maneuver the shelves in a first direction, a second actuator positioned adjacent to the carousel, and a gripper positioned on the second actuator such that the second actuator may maneuver one of the cups by the gripper in a second direction to one of the shelves of the carousel.

METHOD AND/OR SYSTEM FOR PROCESSING DATA STREAMS

Embodiments of methods, apparatuses, devices and/or systems for manipulating character expressions to determine relationships among such character expressions. 120-. (canceled)21. A method comprising:associating indices with a plurality of binary strings stored in a memory;concatenating binary expressions of individual characters of a first character expression to provide a first binary string;determining whether said first binary string matches a second binary among said plurality of binary strings; andselecting a third binary string among said plurality of binary strings stored in said memory based, at least in part, on said first and second binary strings in response to said first and second binary strings not matching.22. The method of claim 21 , and further comprising:determining whether said first binary string matches said third binary string; andselecting a fourth binary string among said plurality of binary strings in said memory based, at least in part, on said first binary and said fourth binary strings in response to said first and third binary strings not matching.23. The method of claim 21 , and wherein said selecting said third binary string further comprises determining whether a first quantity represented by said first binary string is greater than a second quantity represented by said second binary string.24. The method of claim 23 , wherein said indices indicate a sequential ordering of said plurality of binary strings according to quantities represented by said plurality of binary strings claim 23 , and wherein said selecting said third binary string further comprises selecting said third binary string from among binary strings associated with indices indicative of binary strings representing quantities greater than said second quantity in response to determining said first quantity is greater than said second quantity.25. The method of claim 23 , wherein said selecting said third binary string further comprises selecting said third binary string ...

MANIPULATION AND/OR ANALYSIS OF HIERARCHICAL DATA

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for analyzing hierarchical data are disclosed. 170-. (canceled)71. A method of presenting a query to a database , or a portion thereof , comprising:accessing instructions from one or more physical memory devices for execution by one or more processors;executing the instructions accessed from the one or more physical memory devices by the one or more processors;storing, in at least one of the physical memory devices, signal values, including numerical signal values, resulting from having executed the accessed instructions on the one or more processors, wherein the one or more physical memory devices also store the database, or the portion thereof;wherein the accessed instructions transform at least some content of the database, or the portion thereof, to the form of a hierarchically structured tree via one or more numerical signal values corresponding to at least some content within the database, or the portion thereof;wherein the executing the transformation instructions comprises:generating the hierarchically structured tree via the one or more numerical signal values, wherein the hierarchically structured tree comprises the at least some content within the database, or the portion thereof; andwherein the executing the transformation instructions comprises:presenting a hierarchically structured tree query to the database, or the portion thereof, via at least one numerical signal value to fetch the at least some content within the database, or the portion thereof.72. The method of claim 71 , and wherein the executing the transformation instructions comprises:identifying at least some of a plurality of partial subtrees of the hierarchically structured tree;enumerating at least some partial subtrees of the at least some identified partial subtrees;associating the at least one numerical signal ...

MANIPULATION AND/OR ANALYSIS OF HIERARCHICAL DATA

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for analyzing hierarchical data are disclosed. 170-. (canceled)71. A method of querying a database , or a portion thereof , comprising:accessing instructions from one or more physical memory devices for execution by one or more processors;executing the instructions accessed from the one or more physical memory devices by the one or more processors;storing, in at least one of the physical memory devices, signal values, including numerical signal values, resulting from having executed the accessed instructions on the one or more processors, wherein the one or more physical memory devices also store the database or the portion thereof;wherein the accessed instructions to transform the database, or the portion thereof, after being provided in the form of a tree, to one or more target numerical signal values;wherein the executing the transformation instructions comprises:representing the tree, comprising at least a node or at least an edge in the form of signals and/or states, as the one or more target numerical signal values substantially in accordance with transformation of the tree to the one or more target numerical signal values based at least in part on an association of trees and numerical signal values, the tree comprising electronic content including binary digital signals and/or states; andwherein the executing the transformation instructions further comprises:identifying at least some of a plurality of partial subtrees of the tree, the plurality of partial subtrees also in the form of signals and/or states;enumerating at least some partial subtrees of the at least some identified partial subtrees;associating the one or more target numerical signal values with the at least some enumerated partial subtrees; andcomparing one or more probe numerical signal values, representing the query to ...

Method of Manufacturing an Antenna

A method of manufacturing a stamped antenna includes providing a sheet of metallic material for a first stamping. A first stamping of the sheet of metallic material is performed to form at least one antenna that includes traces, contacts, a carrier connected to the traces, and at least one tie-bar connected between the traces. A pad is provided with at least one pressure sensitive adhesive area that is provided on the pad in substantially the same shape as the traces of the antenna. The pressure sensitive adhesive area is aligned with the traces of the antenna, and then bonded to the traces of the at least one antenna. A second stamping of the at least one antenna and the pressure sensitive adhesive is then performed to remove the at least one carrier and the at least one tie-bar connected to the traces. 1. A system for manufacturing an antenna , comprising:a first stamping station including a first stamping press, the first stamping station receiving a sheet of metallic material and performing a first stamping of the sheet of metallic material to form at least one antenna including traces, contacts, a carrier connected to the traces, and at least one tie-bar connected between the traces;a pressure sensitive adhesive alignment station, the pressure sensitive adhesive alignment station (i) receiving the at least one antenna stamped for a first time by the first stamping station, and (ii) aligning a pressure sensitive adhesive area of a pad with the traces of the at least one antenna, wherein the pressure sensitive adhesive area is substantially the same shape as the traces of the at least one antenna;a bonding station, the bonding station bonding the pressure sensitive adhesive area to the traces of the at least one antenna after the pressure sensitive adhesive area has been aligned with the traces of the at least one antenna; anda second stamping station including a second stamping press, the second stamping station performing a second stamping of the at least one ...

TRACKING DATA USAGE IN WIRELESS NETWORKS

A method may include determining a number of user devices that can access data services in a wireless network and storing information identifying the determined number of user devices for each of a number of sectors for each of a number of periods of time. The method may also include receiving a request from a first user device associated with a first user for access to data services during a first period of time, accessing the stored information to determine whether to grant the request and providing access to data services via the wireless network to the first user device. The method may further include excluding data usage by the first user device during the first period of time from being applied against a data limit associated with the user's data plan. 1. A computer-implemented method , comprising:determining, by at least one computing device, a number of user devices that can access data services in a wireless network via each of a plurality of sectors or areas for each of a plurality of periods of time based on capacity in the wireless network;storing, by the at least one computing device, information identifying the determined number of user devices for each of the plurality of sectors or areas for each of the plurality of periods of time;identifying, by the at least one computing device and based on the stored information, at least one period of time in which unlimited data usage is available for use by a plurality of user devices; andforwarding, to at least a first one of the plurality of user devices, information identifying the at least one period of time in which unlimited data usage is available for use by the first user device,wherein the first user device is associated with a first user having a data plan, and wherein data usage by the first user device during the at least one period of time is not applied against a data limit associated with the first user's data plan.2. The computer-implemented method of claim 1 , further comprising:receiving, in ...

SUBSTITUTED AZETIDINE DIHYDROTHIENOPYRIDINES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The present invention relates to novel substituted azetidine dihydrothienopyridines with phosphodiesterase inhibitory activity, and to their use in therapy, and to pharmaceutical compositions comprising the compounds and to methods of treating diseases with the compounds (I) 2. A compound according to claim 1 , wherein Ris phenyl or phenoxy claim 1 , optionally substituted with one of R.3. A compound according to claim 1 , wherein Ris fluoro.4. A compound according to claim 1 , wherein Ris piperidinyl claim 1 , pyrrolidinyl claim 1 , or tetrahydropyranyl; wherein the piperidinyl claim 1 , pyrrolidinyl claim 1 , or tetrahydropyranyl is optionally substituted with one or more substituents independently selected from R.5. A compound according to claim 4 , wherein Ris tetrahydropyranyl.6. A compound according to selected from the group consisting of:(i) (1R)-5-(3-(4-Fluorophenyl)azetidin-1-yl)-7-((tetrahydro-2H-pyran-4-yl)amino)-2,3-dihydrothieno[3,2-b]pyridine 1-oxide;(ii) Methyl (3R)-3-[[(1R)-5-[3-(4-fluorophenyl)azetidin-1-yl]-1-oxido-2,3-dihydrothieno[3,2-b]pyridin-7-yl]amino]piperidine-1-carboxylate;(iii) Methyl (3R)-3-[[(1R)-5-(3-(4-phenylazetidin-1-yl)-1-oxido-2,3-dihydrothieno[3,2-b]pyridin-7-yl]amino]piperidine-1-carboxylate;(iv) (1R)-5-(3-(4-Fluorophenoxy)azetidin-1-yl)-7-((tetrahydro-2H-pyran-4-yl)amino)-2,3-dihydrothieno[3,2-b]pyridine-1-oxide;(v) Methyl (3S)-3-[[(1R)-5-[3-(4-fluorophenoxy)azetidin-1-yl]-1-oxido-2,3-dihydrothieno[3,2-b]pyridine-7-yl]amino]pyrolidine-1-carboxylate;(vi) 1-[(3S)-3-[[(1R)-5-[3-(4-Fluorophenoxy)azetidin-1-yl]-1-oxido-2,3-dihydrothieno[3,2-b]pyridin-7-yl]amino]pyrrolidin-1-yl]ethenone; and(vii) (1R)-5-(3-Phenylazetidin-1-yl)-7-((tetrahydro-2H-pyran-4-yl)amino)-2,3-dihydrothieno[3,2-b]pyridine-1-oxide;or a pharmaceutically acceptable salt, enantiomer, mixture of enantiomers, diastereomer, mixture of diastereomers, hydrate or solvate thereof.7. A pharmaceutical composition comprising a compound according to and one or more ...

METHOD AND/OR SYSTEM FOR PROCESSING DATA STREAMS

Embodiments of methods, apparatuses, devices and/or systems for manipulating character expressions to determine relationships among such character expressions. 1112.-. (canceled)113. A method of processing characters in a stream of characters expressing words , mathematical expressions , numerical expressions , acronyms and/or multicharacter symbols in a particular spoken and/or written language , the method comprising:parsing a stream of characters to obtain one or more first character expressions from the stream of characters, the one or more first character expressions being descriptive of corresponding events and/or transactions;concatenating binary expressions representing individual characters of at least one of said one or more first character expressions in one or more first binary strings, said at least one said one or more first character expressions representing a first alphanumeric value of a first alphanumeric expression, the first alphanumeric expression comprising a concatenation of said individual characters representing digit values at associated positions in the first alphanumeric expression, indicative of ones of said digit value having exactly one of three or more possible unique values; andprocessing a query based, at least in part, on an application of an operator to at least one of said one or more first binary strings to provide a comparison of said first alphanumeric value of said first alphanumeric expression represented by said concatenation of individual characters of said at least one of said one or more first character expressions with a second alphanumeric value represented by one or more second character expressions of said query.114. The method of claim 113 , wherein said first alphanumeric value comprises a sum of products claim 113 , said products comprising individual ones of said digit values multiplied by a position value associated with positions of said digit values multiplied by position values associated with positions of ...

Anti-her2 binding molecules

The present disclosure is directed to binding proteins to the extracellular domain (ECD) of HER2/ErbB2. More particularly, the binding proteins bind to a conformational epitope which is exposed in cells in response to HER2 amplification or activation.

ENUMERATION OF TREES FROM FINITE NUMBER OF NODES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. 1. A method of generating complex two-dimensional graphical hierarchies for more convenient processing and/or storage , a complex two-dimensional graphical hierarchy being in the form of a tree hierarchy , the method comprising:accessing instructions from one or more memory devices for execution by one or more processors;executing instructions accessed from the one or more physically memory devices by the one or more processors;storing, in the at least one of the physical memory devices, signal values resulting from having executed the instructions on the one or more processors;wherein the accessed instructions to generate tree hierarchies; andwherein executing the accessed tree hierarchy generation instructions further comprising:generating at least some tree hierarchies out of a set of possible tree hierarchies;determining for the generated at least some tree hierarchies natural numerals associated with particular ones of the generated at least some tree hierarchies; andstoring, in a memory, the natural numerals,wherein the set of possible tree hierarchies comprises one or more signal values, configurable from a finite number (N) of nodes.219-. (canceled)20. The method of claim 1 , the method further comprising:identifying N−1 arrangements of subtree hierarchy slots coupled to a root node; determining one or more allocations of N−1 nodes among the subtree hierarchy slots in the arrangement, a subtree hierarchy slot being allocated a portion of the N−1 nodes; and', 'for the subtree hierarchy slots, generating one or more possible subtree hierarchies configurable from the portion of the N−1 nodes allocated to the subtree hierarchy slot., 'for an arrangement of subtree hierarchy slots21. The method of claim 20 , the method further comprising:associating the generated one or more possible subtree hierarchies for a subtree hierarchy slot with a natural ...

STORING AND ANALYZING NETWORK TRAFFIC DATA

An improved mechanism is provided for storage, recovery, and analysis of network traffic data, without requiring prohibitive amounts of storage space. Network traffic data is recorded in a sliding buffer. In normal operation, after some period of time, the oldest data in the buffer is deleted, yielding more storage space for more recent data. In response to a trigger event, such as any detected problem, attack, or similar incident, relevant pre-event and post-event data is retained for analysis. 1. A computer-implemented method for buffering and selectively retaining data in an electronic device , comprising:receiving a stream of time-based data, comprising a plurality of data items having time stamps;storing the received data items in a buffer;detecting at least one trigger event, the trigger event being associated with a trigger event time;for each detected trigger event, determining a retention period;retaining at least a subset of the stored data items corresponding to time stamps falling within at least one determined retention period; andstoring the retained data in a storage device.2. The computer-implemented method of claim 1 , further comprising:adding each detected trigger event to an active events list; andautomatically removing the trigger event from the active events list upon expiration of an event expiration period; determining whether the time stamp for each data item falls within the retention period for any trigger event in the active events list; and', 'responsive to the time stamp for a data item falling within the retention period for any trigger event in the active events list, retaining the data item., 'and wherein retaining at least a subset of the stored data items corresponding to time stamps falling within at least one determined retention period comprises3. The computer-implemented method of claim 1 , wherein each retention period comprises:a pre-event retention period representing a time period before the trigger event time; anda post- ...

MANIPULATION AND/OR ANALYSIS OF HIERARCHICAL DATA

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for analyzing hierarchical data are disclosed. 170.-. (canceled)71. A method comprising: identifying a plurality of partial subtrees of the tree, the plurality of partial subtrees also in the form of signals and/or states;', 'enumerating rooted partial subtrees of the identified plurality of partial subtrees;', 'associating the one or more target numerals with the enumerated rooted partial subtrees; and', 'comparing, using the processor, a probe numeral in the form of signals and/or states with the one or more target numerals to detect a presence of a subtree in the tree, wherein the probe numeral is also based, at least in part, on the association of trees and numerals, and wherein a correspondence between the probe numeral and at least one of the one or more target numerals is indicative of a presence of content in the one or more electronic documents comprising binary digital signals and/or states., 'representing a tree comprising at least a node or an edge in the form of signals and/or states, using a processor of a computing device, as one or more target numerals substantially in accordance with transformation of the tree to the one or more target numerals based at least in part on an association of trees and numerals, wherein the tree comprises one or more electronic documents comprising binary digital signals and/or states, the representing a tree comprising72. The method of claim 71 , and further comprising:determining the one or more target numerals based, at least in part, on an association of numerals with the enumerated rooted partial subtrees of the identified plurality of partial subtrees.73. The method of claim 72 , wherein the identifying the plurality of partial subtrees of the tree further comprises:identifying non-terminal nodes of the tree as root nodes of the plurality ...

MANIPULATION AND/OR ANALYSIS OF HIERARCHICAL DATA

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. In particular, methods, apparatus devices and or/or systems for analyzing hierarchical data are disclosed. 170-. (canceled)71. A method of querying a database , or a portion thereof , comprising:accessing instructions from one or more physical memory devices for execution by one or more processors;executing the instructions accessed from the one or more physical memory devices by the one or more processors;storing, in at least one of the physical memory devices, signal values, including numerical signal values, resulting from having executed the accessed instructions on the one or more processors, wherein the one or more physical memory devices also store the database or the portion thereof;wherein the accessed instructions to transform the database, or the portion thereof, after being provided in the form of a target tree, to one or more target numerical signal values;wherein the executing the transformation instructions comprises:representing a probe tree, comprising at least a node or at least an edge in the form of signals and/or states, as one or more probe numerical signal values substantially in accordance with transformation of the probe tree to the one or more probe numerical signal values based at least in part on an association of trees and numerical signal values, wherein the target tree comprises electronic content including binary digital signals and/or states:wherein the executing the transformation instructions further comprises:identifying a plurality of partial subtrees of the probe tree, the plurality of partial subtrees also in the form of signals and/or states;enumerating partial subtrees of the identified partial subtrees;associating the one or more probe numerical signal values with the enumerated partial subtrees; andcomparing the one or more probe numerical signal values, representing a query to the database or the portion ...

Stamped Antenna and Method of Manufacturing

An intermediate product for the manufacture of an antenna includes a pressure sensitive adhesive, one or more stamped traces bonded with the pressure sensitive adhesive, and at least one tie-bar connected between the one or more traces. The at least one tie-bar supports the one or more traces. The one or more traces can be stamped from a sheet of copper. The pressure sensitive adhesive can be a pressure sensitive adhesive pad having more than one pressure sensitive adhesive area. 1. An intermediate product for the manufacture of an antenna , comprising:a pressure sensitive adhesive;one or more stamped traces bonded with the pressure sensitive adhesive; andat least one tie-bar connected between the one or more traces;wherein the at least one tie-bar supports the one or more traces.2. The intermediate product of claim 1 , wherein the one or more traces are stamped from a sheet of copper.3. The method of manufacturing an antenna of claim 1 , wherein the pressure sensitive adhesive is a pressure sensitive adhesive pad having more than one pressure sensitive adhesive area. This application is a divisional of, and claims the benefit of priority to, U.S. patent application Ser. No. 13/833,888 filed on Mar. 15, 2013, the entire disclosure of which is expressly incorporated herein by reference.1. Field of the InventionThe present invention relates to a stamped antenna and a method of manufacturing a stamped antenna, and more specifically, to a method of manufacturing an antenna that includes a first partial initial stamping of the antenna from a sheet of metal, and a subsequent complete stamping of the antenna.2. Related ArtAs communication technology continues to advance, the use of antennas is becoming more widespread and possible applications are broadening. Various types of antennas are not only used for large scale communication, but also for small scale communication between devices for identification purposes and even for electronic device charging.Near field ...

Stamped Antenna and Method of Manufacturing

A stamped antenna and a method of manufacturing includes providing a sheet of metallic material for a first partial stamping. The first partial stamping forms an antenna including traces, contacts, carriers connected to the traces, and tie-bars between the traces. A pressure sensitive adhesive is then bonded to the traces of the antenna. A second complete stamping is then performed on the antenna, including pressure sensitive adhesive, to remove the carriers and tie-bars. An intermediate product for the manufacture of an antenna includes a pressure sensitive adhesive, one or more stamped traces bonded with the pressure sensitive adhesive, and at least one tie-bar connected between the one or more traces supports the one or more traces. 1. A method of manufacturing an antenna , comprising:providing a sheet of metallic material;performing a first stamping of the sheet of metallic material to form at least one antenna, the at least one antenna including traces, contacts, a carrier connected to the traces, and at least one tie-bar connected between the traces;bonding a pressure sensitive adhesive to the traces of the at least one antenna; andperforming a second stamping of the at least one antenna and the pressure sensitive adhesive to remove the at least one carrier and the at least one tie-bar connected to the traces.2. The method of manufacturing an antenna of claim 1 , wherein the first stamping forms more than one antenna as a group connected by at least one tie-bar or the carrier.3. The method of manufacturing an antenna of claim 2 , wherein the pressure sensitive adhesive is a pressure sensitive adhesive pad having more than one pressure sensitive adhesive area.4. The method of manufacturing an antenna of claim 3 , wherein the more than one antenna are separated from one another after the second stamping.5. The method of manufacturing an antenna of claim 1 , wherein the carrier includes at least one pilot hole and the pressure sensitive adhesive includes at least ...

Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection

Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.

Stamped Antenna and Method of Manufacturing

A stamped antenna and a method of manufacturing includes providing a sheet of metallic material for a first partial stamping. The first partial stamping forms an antenna including traces, contacts, carriers connected to the traces, and tie-bars between the traces. A pressure sensitive adhesive is then bonded to the traces of the antenna. A second complete stamping is then performed on the antenna, including pressure sensitive adhesive, to remove the carriers and tie-bars. An intermediate product for the manufacture of an antenna includes a pressure sensitive adhesive, one or more stamped traces bonded with the pressure sensitive adhesive, and at least one tie-bar connected between the one or more traces supports the one or more traces. 1. A method of manufacturing an antenna , comprising:providing a sheet of metallic material;performing a first stamping of the sheet of metallic material to form at least one antenna, the at least one antenna including traces, contacts, a carrier connected to the traces, and at least one tie-bar connected between the traces;bonding a pressure sensitive adhesive to the traces of the at least one antenna; andperforming a second stamping of the at least one antenna and the pressure sensitive adhesive to remove the at least one carrier and the at least one tie-bar connected to the traces.2. The method of manufacturing an antenna of claim 1 , wherein the first stamping forms more than one antenna as a group connected by at least one tie-bar or the carrier.3. The method of manufacturing an antenna of claim 2 , wherein the pressure sensitive adhesive is a pressure sensitive adhesive pad having more than one pressure sensitive adhesive area.4. The method of manufacturing an antenna of claim 3 , wherein the more than one antenna are separated from one another after the second stamping.5. The method of manufacturing an antenna of claim 1 , wherein the carrier includes at least one pilot hole and the pressure sensitive adhesive includes at least ...

GROUNDING CLAMPS

A grounding clamp is provided. The grounding clamp comprises a body portion having first and second sides, first and second fingers extending from the first side of the body portion, a first set of teeth extending from the first side of the body portion, the first set of teeth positioned between the first and second fingers, and a second set of teeth extending from the second side of the body portion. 1. A grounding clamp for a solar panel array , comprising:a body having top and bottom surfaces, first and second ends, and first and second sides,first and second end fingers extending from the first and second ends of the body at a first angle in a direction of the bottom surface and positioned between adjacent solar panel frames;first and second pairs of side fingers extending from the first and second sides of the body at a second angle in a direction of the bottom surface and positioned against upper surfaces of adjacent solar panel frames;first and second sets of teeth positioned on the first and second sides of the body, the first set of teeth positioned between the first pair of side fingers, and the second set of teeth positioned between the second pair of side fingers, the first and second sets of teeth extending from the body at a third angle in a direction of the bottom surface to penetrate the top surface of adjacent solar panel frames; anda central aperture in the body configured to receive a bolt to secure the grounding clamp and adjacent solar panel frame to a mounting rail.2. The grounding clamp of claim 1 , wherein the clamp is manufactured from a single sheet of metal.3. The grounding clamp of claim 1 , further comprising a second aperture to receive a grounding wire therethrough.4. The grounding clamp of claim 1 , wherein one of the first or second end fingers includes a fastener extension extending from an end of the one of the first or second end fingers claim 1 , the fastener extension having a narrowed neck to receive a wire clamp. This ...

Grounding Spacer

A grounding spacer is provided. The grounding spacer comprising a circular body having a top surface, a bottom surface, and a central aperture, and a plurality of radially spaced penetration features, wherein at least one of the penetration features has at least a portion thereof extending from the top surface, and wherein at least one of the penetration features has at least a portion thereof extending from the bottom surface. 1. A grounding spacer comprising:a body having a top surface, a bottom surface, and a central aperture; anda plurality of apertures extending through the body;a rim extending about each of the plurality of apertures, wherein at least one of the rims is upstanding from the top surface and at least one of the rims is depending from the top surface.2. The grounding spacer of claim 1 , wherein the grounding spacer is of a single sheet construction.3. The grounding spacer of claim 1 , wherein the apertures are round.4. The grounding spacer of claim 1 , wherein the apertures are elongate.5. The grounding spacer of claim 1 , wherein each of the plurality of apertures has rims alternatingly extending in opposite directions.6. The grounding spacer of claim 4 , wherein each of the plurality of apertures has an upstanding rim portion and a depending rim portion.7. The grounding spacer of claim 6 , wherein the upstanding and depending rims are side by side around an aperture.8. The grounding spacer of claim 6 , wherein the upstanding and depending rims are separated by an inner and outer arcs.9. A method of manufacturing a grounding spacer comprising:stamping a flat piece of sheet metal to form a flat blank grounding spacer having a circular shape, a central aperture, and a plurality of apertures; andstamping the flat blank grounding spacer to form a plurality of apertures, wherein at least one of the apertures has a rim extending in a first direction, and at least one of the other apertures has a rim extending in a second direction opposite to the first ...

Multi-Piece Shield

This disclosure relates to a multi-piece shield comprising a fence, a lid, and an insert. The lid attaches to the fence, which is attached to the circuit board. The lid is a relatively thick, flexible material for supporting the insert. The lid has a recess so that the insert can be recessed into the lid to position the insert closer to the circuit for enhanced heat absorption. The insert is made of a thicker heat absorbing material than the lid, again to facilitate heat absorption. The insert can be press-fit into the recess of the lid. The lid can have a dovetail configuration to retain the insert in the lid. 1. A multi-piece electromagnetic radiation and heat dissipation shield for electrical components , comprising:a fence having sidewalls forming an enclosure surrounding electrical components;a lid having a top wall, an interior wall depending from the top wall and defining a recess, a shelf extending from the interior wall and offset from the top wall, the shelf having an inner edge defining an aperture, and a plurality of depending fingers about an outer periphery of the lid, the plurality of depending fingers engaging the sidewalls of the fence; andan insert having a perimeter sized and shaped to be received within the recess defined by the interior wall and on the shelf, wherein the insert shields the electrical components from electromagnetic radiation and dissipates heat from the electrical components.2. The multi-piece shield of claim 1 , wherein the shelf extends parallel to the top wall of the lid.3. The multi-piece shield of claim 1 , wherein a bottom surface of the insert contacts a top surface of the shelf of the lid.4. The multi-piece shield of claim 1 , wherein the insert is press-fit into the lid.5. The multi-piece shield of claim 4 , wherein the insert has an outer edge that frictionally engages the interior wall of the lid.6. The multi-piece shield of claim 1 , wherein the insert is directly exposed to the electrical components through the ...

ENUMERATION OF TREES FROM FINITE NUMBER OF NODES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. 1. A method comprising:enumerating possible trees configurable from a finite number (N) of nodes; anddetermining for the enumerated trees natural numerals associated with particular ones of the enumerated trees, the natural numerals being based, at least in part, on a predetermined association between trees and natural numerals.2. The method of claim 1 , wherein the method further comprises:determining one or more allocations of the finite number of nodes among subtree slots, an allocation defining a portion of the finite number of nodes to a subtree slot in the allocation;for a subtree slot in an allocation, enumerating a set containing one or more possible subtrees configurable from the portion of the finite number of nodes allocated to the subtree slot.3. The method of claim 2 , wherein the method further comprises pushing the elements of the enumerated set of subtrees to generate a pushed set corresponding with the subtree slot.4. The method of claim 3 , wherein the method further comprises merging pushed sets of subtrees in an allocation of the finite number of nodes to subtree slots to determine a set of trees that are configurable from the allocation.5. The method of claim 4 , wherein the method further comprises determining the one or more possible trees configurable from the finite number of nodes as the union of trees which are configurable from the allocations of the finite number of nodes among subtree slots.6. The method of claim 4 , the method further comprising:representing a subtree in a pushed set of subtrees of the allocation with a natural numeral; andmultiplying a natural numeral corresponding to an element in the pushed set of subtrees in the allocation with a natural numeral corresponding to an element of one or more other sets of pushed subtrees in the allocation to determine one or more natural numerals corresponding with at ...

ENUMERATION OF TREES FROM FINITE NUMBER OF NODES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. 1. A method of enumerating possible complex two-dimensional graphical hierarchies for more convenience processing and/or storage , a complex two-dimensional graphical hierarchy being in the form of a tree hierarchy , the method comprising:enumerating possible tree hierarchies, in which a tree hierarchy comprises one or more signal values, configurable from a finite number (N) of nodes;determining for the enumerated tree hierarchies natural numerals associated with particular ones of the enumerated tree hierarchies, the natural numerals being based, at least in part, on a predetermined association between the tree hierarchies and the natural numerals; andstoring, in a memory, the natural numbers, a natural number comprising one or more signal values.218-. (canceled)19. The method of claim 1 , wherein the natural numeral comprises a product of one or more component natural numerals claim 1 , the product of one or more component natural numerals comprising a subtree hierarchy among subtree hierarchies which are merged at a root node to form the associated enumerated tree hierarchy.20. The method of claim 1 , the method further comprising:identifying N−1 arrangements of subtree hierarchy slots coupled to a root node; determining one or more allocations of N−1 nodes among the subtree hierarchy slots in the arrangement, a subtree hierarchy slot being allocated a portion of the N−1 nodes; and', 'for the subtree hierarchy slots, enumerating one or more possible subtree hierarchies configurable from the portion of the N−1 nodes allocated to the subtree hierarchy slot., 'for an arrangement of subtree hierarchy slots21. The method of claim 20 , the method further comprising:associating the enumerated one or more possible subtree hierarchies for a subtree hierarchy slot with a natural numeral, the natural numeral being based, at least in part, on the association ...

Grounding Clamps

A grounding clamp is provided. The grounding clamp comprises a body portion having first and second sides, first and second fingers extending from the first side of the body portion, a first set of teeth extending from the first side of the body portion, the first set of teeth positioned between the first and second fingers, and a second set of teeth extending from the second side of the body portion. 1. A grounding clamp , comprising:a first side body portion and a second side body portion coupled by a bend formed therebetween such that the first side body portion and the second side body portion are perpendicular to one another;a first finger and a second finger, the first finger and the second finger extending away from the first side body portion such that the first finger and the second finger directly contact a top surface of a solar panel frame to maintain the solar panel frame in position;a first standoff and a second standoff, the first standoff and the second standoff extending perpendicularly from the first side body portion such that the first standoff and the second standoff directly contact a side surface of the solar panel frame;a first set of teeth and a second set of teeth, the first set of teeth having a plurality of teeth arranged adjacent to each other and extending at an angle from the first side body portion and positioned between the first finger and the second finger such that the first set of teeth penetrate at an acute angle with the top surface of the solar panel frame and the second set of teeth having a plurality of teeth arranged adjacent to each other and extending from the second side body portion in a same plane as the second side body portion, and generally perpendicular to the first side body portion, such that the second set of teeth penetrate a mounting rail;a first through hole positioned in a center of the first side body portion; anda tab formed in and bent from the second side body portion such that the tab forms an archway ...

Omnichannel data communications system using artificial intelligence (ai) based machine learning and predictive analysis

A system for determining context and intent in a conversation using machine learning (ML) based artificial intelligence (AI) in omnichannel data communications is disclosed. The system may comprise a data store to store and manage data within a network, a server to facilitate operations using information from the one or more data stores, and a ML-based AI subsystem to communicate with the server and the data store in the network. The ML-based AI subsystem may comprise a data access interface to receive data associated with a conversation with a user via a communication channel. The ML-based AI subsystem may comprise a processor to provide a proactive, adaptive, and intelligent conversation by applying hierarchical multi-intent data labeling framework, training at least one model with training data, and generating and deploying a production-ready model based on the trained and retained at least one model.

Easy adjust tensioner assembly

A tensioning bar assembly for a tensioning assembly of a drive system of an agricultural machine includes a longitudinal bar having a top end, a bottom end, and a threaded portion. An attachment device is coupled to the top end to attach to a tensioning arm. A compression spring is located around a portion of the longitudinal bar. A first spring retainer engages with and retains a first end of the spring. A first locking nut fits to the threaded portion of the bar and retains the first spring retainer longitudinally in place relative to the bar. The longitudinal bar is rotationally freely coupled to the attachment device to permit free axial rotation of the bar about its longitudinal axis relative to the attachment device, and an engagement head is attached to and located at or proximate the bottom end of the longitudinal bar for engagement with a tool.

RIGID FOAMS

A rigid foam including the reaction product of an (poly)isocyanate, and a polyethercarbonate polyol copolymer is described. The polyethercarbonate polyol copolymer is derived from the copolymerisation of one or more epoxides with CO2, wherein the total-CO2— content of the polyethercarbonate polyol copolymer is between 1 and 40 wt %, the carbonate linkages are <95% of the total linkages from the copolymerisation, and the molecular weight is between 100 to 5000 g/mol. The foam is a polyurethane foam, more typically, a polyisocyanurate or a mixed polyisocyanurate/polyurethane foam. Methods, polyols and compositions for producing the foams are also described. 1. A rigid foam comprising the reaction product of an (poly)isocyanate , and a polyethercarbonate polyol copolymer wherein the polyethercarbonate polyol copolymer is derived from the copolymerisation of one or more epoxides with CO , wherein the total-CO— content of the polyethercarbonate polyol copolymer is between 1 and 40 wt % , the carbonate linkages are <95% of the total linkages from the copolymerisation , and the molecular weight is between 100 to 5000 g/mol.2. The rigid foam according to which is a polyurethane foam.3. The rigid foam according to claim 1 , wherein the polyethercarbonate polyol copolymer forms from 20 to 100 wt % of the total polyol present during the reaction with the (poly) isocyanate to produce the rigid foam.4. The rigid foam according to claim 1 , wherein the COcontent in the polyether carbonate polyol copolymer is 5-35 wt %.5. The rigid foam according to claim 1 , wherein the carbonate content of the polyethercarbonate polyol is up to 90% of a fully alternating polycarbonate polyol which is free of ether linkages6. The rigid foam according to claim 1 , wherein the ether linkage content of the polyethercarbonate polyol copolymer is at least 10%.7. The rigid foam according to claim 1 , wherein more than 95% of the chain ends of the polyethercarbonate polyol copolymer are —OH groups.8. ...

Fault identification and isolation in an electric propulsion system

An electric propulsion system is described that includes at least one branch for distributing electrical power, provided by a power source, to one or more loads. The at least one branch is partitioned into one or more zones and comprises a plurality of branch isolation devices that are configured to isolate the at least one branch from the power source in response to a fault current at the at least one branch. In addition, the at least one branch comprises a respective pair of zone isolation devices for each respective zone from the one or more zones. The respective pair of zone isolation devices for each respective zone is configured to isolate the respective zone from the at least one branch, during a test of the at least one branch for identifying which of the one or more zones is a source of the fault current.

Fault tolerant superconducting magnetic energy storage (smes) device

A superconducting magnetic energy storage (SMES) device having a plurality of interwoven windings provides for alternative discharge paths for energy stored as magnetic fields in the windings in response to an open-circuit winding fault in one of the windings.

Grounding Clamps

A grounding clamp is provided. The grounding clamp comprises a body portion having first and second sides, first and second fingers extending from the first side of the body portion, a first set of teeth extending from the first side of the body portion, the first set of teeth positioned between the first and second fingers, and a second set of teeth extending from the second side of the body portion. 1. A grounding clamp , comprising:a body portion having first and second sides;first and second fingers extending from the first side of the body portion;a first set of teeth extending from the first side of the body portion, the first set of teeth positioned between the first and second fingers; anda second set of teeth extending from the second side of the body portion;the body portion comprising a vertical wall portion and a top wall portion, the vertical wall portion extending at an angle with respect to the top wall portion, the first set of teeth extending from the top wall portion and the second set of teeth extending from the vertical wall portion;the vertical wall portion comprising a tab having an aperture, the tab extending at an angle from the vertical wall, the aperture of the tab vertically aligned with the through hole of the top wall portion; andthe grounding clamp comprising an end grounding clamp for connecting a solar panel frame and a mounting rail.2. The grounding clamp of claim 1 , wherein the grounding clamp is manufactured from a single sheet of metal.3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. The grounding clamp of claim 2 , wherein the vertical wall portion comprises first and second sidewalls extending from opposing ends of the vertical wall portion.11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. The grounding clamp of claim 1 , wherein the top wall portion comprises first and second ...

Dispensing device

A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

Media Processing

This disclosure relates to a computer implemented method of media processing, computer program and media processing system. Source media relating to a mass participation event is received, wherein the source media includes a source video of the mass participation event. A plurality of video segments in the source video are identified, wherein each different video segment relates to a different participant in the mass participation event one of the plurality of video segments are matched to a particular participant of the mass participation event. A media clip is then output relating to the particular participant, wherein the media clip comprises the video segment that has been matched to the particular participant. 1. A computer implemented method of media processing comprising:receiving source media relating to a mass participation event, wherein the source media comprises a source video of the mass participation event;identifying a plurality of video segments in the source video, wherein each different video segment relates to a different participant in the mass participation event;determining a matching video segment of the plurality of video segments corresponding to a particular participant of the mass participation event; andoutputting a media clip relating to the particular participant, wherein the media clip comprises the matching video segment corresponding to the particular participant.2. The method of claim 1 , wherein the source media further comprises an audio track claim 1 , and wherein determining the matching video segment corresponding to the particular participant of the mass participation event is based at least in part on the audio track.3. The method of claim 2 , wherein determining the matching video segment corresponding to the particular participant of the mass participation event comprises:performing audio recognition on at least part of the audio track to recognise an audible identifier;comparing the audible identifier against a first list ...

METHOD AND/OR SYSTEM FOR PERFORMING TREE MATCHING

Embodiments of methods, apparatuses, devices and/or systems for performing tree matching are disclosed. 160-. (canceled)61. A method of performing tree matching comprising:executing instructions on one or more processors of one or more computing devices to:subdivide a target tree and a query tree;assign an individual and unique subdivided target tree numeral to at least one of subdivided target tree structures and assign an individual and unique subdivided query tree numeral to at least one of subdivided query tree structures, based at least in part on an association between trees and numerals, wherein the association between trees and numerals comprises to assign individual and unique numerals to associated and unique tree structures; andmatch the individual and unique subdivided query tree numeral with respect to the individual and unique subdivided target tree numeral.62. The method of claim 61 , wherein to assign the individual and unique subdivided target tree numeral to the at least one of the subdivided target tree structures comprises accessing a data structure stored in one or more physical memory devices to identify the individual and unique target tree numeral associated with the at least one of the subdivided target tree structures.63. The method of claim 62 , wherein accessing the data structure stored in one or more physical memory devices to identify the individual and unique subdivided target tree numeral associated with the at least one of the subdivided target tree structures comprises performing a table look up operation to determine the individual and unique subdivided query tree numeral associated with the at least one of the subdivided query tree structures64. The method of claim 61 , wherein assigning the individual and unique subdivided query tree numeral to the at least one of the subdivided query tree structures comprises accessing a data structure stored in one or more physical memory devices to identify the individual and unique query ...

ENUMERATION OF TREES FROM FINITE NUMBER OF NODES

Embodiments of methods, apparatuses, devices and/or systems for manipulating hierarchical sets of data are disclosed. 1112-. (canceled)113. A method of generating complex two-dimensional graphical hierarchies for more convenient processing and/or storage , a complex two-dimensional graphical hierarchy being in the form of a tree hierarchy , the method comprising:accessing instructions from one or more physical memory devices for execution by one or more processors;executing instructions accessed from the one or more physical memory devices by the one or more processors;storing, in the at least one of the physical memory devices, signal values resulting from having executed the instructions on the one or more processors, wherein the one or more physical memory devices also store a database or a portion thereof;wherein the accessed instructions to transform the database, or the portion thereof, to one or more tree hierarchies; andwherein executing the accessed tree hierarchy transformation instructions further comprising:generating at least some tree hierarchy structures and associated tree label values;determining, for the generated at least some tree hierarchy structures and associated tree label values, symbol values associated therewith; andstoring, in the at least one of the physical memory devices, the symbol values.114. The method of claim 113 , the method further comprising: 'identifying subtree hierarchies coupled to a root node.', 'for respective ones of the at least some tree hierarchy structures and associated tree label values,'}115. The method of claim 114 , wherein the symbol values comprise numerical values claim 114 , the method further comprising:associating the generated at least some tree hierarchy structures and associated tree label values with a numerical value.116. The method of claim 115 , wherein the numerical value associated with a tree hierarchy structure and associated tree label value of the at least some tree hierarchy structures and ...

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Monoclonal antibody 175 targeting the egf receptor and derivatives and uses thereof

The present invention relates to antibodies, particularly antibody 175, and fragments thereof or antibodies derived therefrom, which bind to the EGF receptor, particularly to amplified or overexpressed epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. These antibodies are useful in the diagnosis and treatment of cancer. Recombinant or hybrid antibodies having the variable region heavy or light chain sequence(s) of antibody 175 are also provided. The antibodies of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

EGF receptor epitope peptides and uses thereof

The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Antibodies to EGF receptor epitope peptides

The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.

Antibodies to EGF receptor epitope peptides and uses thereof

The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.

Use of anti-egfr antibodies in treatment of egfr mutant mediated disease

Use of anti-egfr antibodies in treatment of egfr mutant mediated disease

The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.

Use of anti-EGFR antibodies in the treatment of diseases mediated by a mutant EGFR

Un anticuerpo mAB806 anti-EGFR o un fragmento de unión al antígeno del mismo para su uso en el tratamiento de un cáncer mediado por el EGFR resistente a un inhibidor de la cinasa de tirosina en un mamífero, en el que dicho cáncer resistente mediado por el EGFR comprende una mutación secundaria T790M en el EGFR. An mAB806 anti-EGFR antibody or an antigen-binding fragment thereof for use in the treatment of an EGFR mediated cancer resistant to a tyrosine kinase inhibitor in a mammal, wherein said resistant cancer mediated by the EGFR comprises a secondary mutation T790M in the EGFR.

Use of anti-egfr antibodies in treatment of egfr mutant mediated disease

The present invention relates to the treatment of EGFR-mediated disease, particularly cancer, which is resistant to tyrosine kinase inhibitor therapies. Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided. The invention provides methods for the treatment of tyrosine kinase inhibitor resistant cancers with anti-EGFR antibodies. Methods for treatment of recurrent lung cancer, including non-small cell lung carcinoma which is resistant to tyrosine kinase inhibitors, with the antibody anti-EGFR mAb806 are described.

Use of anti-egfr antibodies in treatment of egfr mutant mediated disease

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to EGFR on tumor cells that overexpress EGFR, and on tumor cells that express the truncated version of the EGFR receptor, de2-7 EGF. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

SPECIFIC UNION PROTEINS AND ITS USES

Fragmentos de éstos, que se unen al receptor del factor de crecimiento epidérmico (EGFR) amplificado y a la version truncada del EGFR, de2-7. En particular, el epitope reconocido por los miembros de union específicos, particularmente los anticuerpos y los fragmentos de éstos, se ve potenciado o es evidente al haber una modificacion post-traduccional aberrante. Estos miembros de union específicos son utiles en el diagnostico y el tratamiento del cáncer. Los miembros de union también pueden usarse en la terapia, en combinacion con agentes quimioterapéuticos o anticancerosos y/o con otros anticuerpos o fragmentos de éstos. Reivindicacion 1: Un anticuerpo aislado caracterizado porque es capaz de unirse al EGFR en tumores que contienen amplificaciones del gen del EGFR, donde las células de dichos tumores contienen multiples copias del gen del EGFR, y en tumores donde se expresa la version truncada del receptor del EGFR de2-7, donde dicho anticuerpo no se une al péptido de union al EGFR de2-7, que consiste en la secuencia de aminoácidos de SEQ ID Ns 13, donde dicho anticuerpo se une a un epitope en la secuencia de residuos 287 - 302 (SEQ ID Ns 14) del EGFR humano salvaje, y donde dicho anticuerpo no comprende una region variable de la cadena pesada con la secuencia de aminoácidos que se detalla en SEQ ID Ns 11 ni comprende una region variable de la cadena liviana que tiene la secuencia de aminoácidos que se detalla en SEQ ID Ns 12. Fragments of these, which bind to the amplified epidermal growth factor receptor (EGFR) and to the truncated version of the EGFR, 2-7. In particular, the epitope recognized by the specific binding members, particularly the antibodies and fragments thereof, is enhanced or is evident as there is an aberrant post-translational modification. These specific union members are useful in the diagnosis and treatment of cancer. Binding members can also be used in therapy, in combination with chemotherapeutic or anticancer agents and / or with other ...

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

ANTIBODY ANTI-EPIDERMAL GROWTH FACTOR (EGFR) ANTIBODY ISOLATED AND IMMUNOCONJUGATE COMPRISING A CYTOTOXIC AGENT AND SUCH ANTIBODY

proteínas de ligação específica e usos das mesmas. a presente invenção relaciona-se a membros de ligação especlficos, particularmente anticorpos e fragmentos dos mesmos, que se ligam ao receptor do fator de crescimento epidermal (egfr) amplificado e ao truncamento de 2-7 egfr do egfr. em particular, o epltopo reconhecido pelos membros de ligação específicos, particularmente anticorpos e fragmentos dos mesmos, é aumentado ou evidente sob modificação pós-traducional aberrante. esses membros de ligação específicos são úteis no diagnóstico e tratamento de câncer. os membros ligantes da presente invenção podem também ser úteis na terapia em combinação com quimioterápicos ou agentes anti-câncer e/ou com outros anticorpos ou fragmentos dos mesmos. specific binding proteins and their uses. The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to the amplified epidermal growth factor (egfr) receptor and to the 2-7 egfr truncation of the egfr. in particular, the epitope recognized by specific binding members, particularly antibodies and fragments thereof, is increased or evident under aberrant post-translational modification. these specific binding members are useful in the diagnosis and treatment of cancer. the binding members of the present invention may also be useful in combination therapy with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Anti-egfr antibodies and uses thereof

The present invention relates to specific binding members, particularly humanized mAb806 antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR), to the de2-7 EGFR truncation of the EGFR, and to EGFR with high mannose glycosylation. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

SPECIFIC UNION PROTEINS AND ITS USES

Miembros de unión específicos, particularmente anticuerpos y fragmentos de éstos, que se unen al receptor del factor de crecimiento epidérmico (EGFR) amplificado y a la versión truncada del EGFR, de 2-7. En particular, el epitope reconocido por los miembros de unión específicos, particularmente los anticuerpos y los fragmentos de éstos, se ve potenciado o es evidente al haber una modificación pos-traduccionaI aberrante. Estos miembros de unión específicos son útiles en el diagnóstico y el tratamiento del cáncer. Los miembros de unión e la presente invención también pueden usarse en la terapia, en combinación con agentes quimioterapéuticos o anticancerosos y/o con otros anticuerpos o fragmentos de éstos. Specific binding members, particularly antibodies and fragments thereof, that bind to the amplified epidermal growth factor receptor (EGFR) and the truncated version of the EGFR, 2-7. In particular, the epitope recognized by the specific binding members, particularly the antibodies and fragments thereof, is enhanced or is evident as there is an aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention can also be used in therapy, in combination with chemotherapeutic or anticancer agents and / or with other antibodies or fragments thereof.

SPECIAL CONNECTION PROTEINS AND THEIR USES

Η παρούσα εφεύρεση αφορά σε μέλη ειδικής σύνδεσης, ιδιαιτέρως αντισώματα και θραύσματα αυτών, που συνδέονται προς ενισχυμένο υποδοχέα επιδερμικού αυξητικού παράγοντα (EGFR) και προς τον απο2-7 EGFR ακρωτηριασμό του EGFR. Ιδιαιτέρως, ο επίτοπος που αναγνωρίζεται από μέλη ειδικής σύνδεσης, ιδιαιτέρως αντισώματα και θραύσματα αυτών, ενισχύεται ή εκδηλώνεται κατά την παρεκκλίνουσα του κανονικού μεταμεταφραστική τροποποίηση. Αυτά τα μέλη ειδικής σύνδεσης είναι χρήσιμα στη διάγνωση και θεραπεία καρκίνου. Τα μέλη σύνδεσης της παρούσας εφεύρεσης μπορεί επίσης να χρησιμοποιηθούν στη θεραπεία σε συνδυασμό με χημειοθεραπευτικά ή αντικαρκινικούς παράγοντες ή/και με άλλα αντισώματα ή θραύσματα αυτών. The present invention relates to specific binding members, in particular antibodies and fragments thereof, that bind to an enhanced epidermal growth factor receptor (EGFR) and to EGFR2-7 EGFR amputation. In particular, the epitope recognized by specific binding members, in particular antibodies and fragments thereof, is amplified or expressed during aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. Binding members of the present invention may also be used in the treatment in combination with chemotherapeutic or anticancer agents and / or with other antibodies or fragments thereof.

SPECIFIC BINDING PROTEINS AND APPLICATIONS THEREOF

Proteínas de unión específicas y sus usos

Miembros de unión específicos, particularmente anticuerpos y fragmentos de éstos, que se unen al receptor del factor de crecimiento epidérmico (EGFR) amplificado y a la versión truncada del EGFR, de2-7. En particular, el epitope reconocido por los miembros de unión específicos, particularmente los anticuerpos y los fragmentos de éstos, se ve potenciado o es evidente al haber una modificación post-traduccional aberrante. Estos miembros de unión específicos son útiles en el diagnóstico y el tratamiento del cáncer. Los miembros de unión de la presente invención también pueden usarse en la terapia, en combinación con agentes quimioterapéuticos o anticancerosos y/o con otros anticuerpos o fragmentos de éstos.

Specific binding proteins and their use

Anticuerpo anti-receptor de factor de crecimiento epidérmico (EGFR) aislado, en el que dicho anticuerpo comprende una región variable de cadena pesada que comprende la secuencia de aminoácidos establecida en la SEQ ID NO: 164 y una región variable de cadena ligera que comprende la secuencia de aminoácidos establecida en la SEQ ID NO: 166. Isolated epidermal growth factor (EGFR) anti-receptor antibody, wherein said antibody comprises a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 164 and a light chain variable region comprising the amino acid sequence established in SEQ ID NO: 166.

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof,

Specifiniai rišimosi baltymai ir jų panaudojimai

Proteinas de enlace especifico y usos de las mismas.

La presente invención se refiere a miembros de enlace específico, particularmente anticuerpos y fragmentos de los mismos, que enlazan al receptor de factor de crecimiento epidérmico (EGFR) amplificado y al truncado de2-7 EGFR de EGFR. En particular, el epítope reconocido por los miembros de enlace específico, particularmente anticuerpos y fragmentos de los mismos, se aumenta o es evidente al momento de la modificación post-traducción aberrante. Estos miembros de enlace específicos son útiles en el diagnóstico y tratamiento de cáncer. Los miembros de enlace de la presente invención también se pueden utilizar en terapia y combinación con quimioterapéuticos o agentes anti-cáncer y/o con otros anticuerpos o fragmentos de los mismos.

Specific binding proteins and uses thereof

THE PRESENT INVENTION RELATES TO SPECIFIC BINDING MEMBERS, PARTICULARLY ANTIBODIES AND FRAGMENTS THEREOF, WHICH BIND TO AMPLIFIED EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND TO THE DE2-7 EGFR TRUNCATION OF THE EGFR.IN PARTICULAR, THE EPITOPE RECOGNIZED BY THE SPECIFIC BINDING MEMBERS, PARTICULARLY ANTIBODIES AND FRAGMENTS THEREOF, IS ENHANCED OR EVIDENT UPON ABERRANT POST-TRANSLATIONAL MODIFICATION.THESE SPECIFIC BINDING MEMBERS ARE USEFUL IN THE DIAGNOSIS AND TREATMENT OF CANCER. THE BINDING MEMBERS OF THE PRESENT INVENTION MAY ALSO BE USED IN THERAPY IN COMBINATION WITH CHEMOTHERAPEUTICS OR ANTI-CANCER AGENTS AND/OR WITH OTHER ANTIBODIES OR FRAGMENTS THEREOF.

Specific binding proteins and uses thereof

Disclosed are nucleic acid and amino acid sequences for the heavy and light chain variable regions of a humanised antibody hu806 that binds to EGFR. Also claimed is a method of synthesising the antibody using a recombinant vector and host cell.

BINDING PROTEINS TO THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)

Se refiere a un anticuerpo aislado anti-Receptor del Factor de Crecimiento Epidermico (EGFR), que comprende una region variable de cadena pesada que comprende la secuencia de aminoacidos SEQ ID N°22 y una region variable de cadena liviana que comprende la secuencia de aminoacidos SEQ ID N°27, asi como una marca detectable o funcional, la cual es una droga unida de manera covalente y un acido nucleico aislado que lo codifica. Dicho anticuerpo se une al EGFR en tumores que contiene amplificaciones del gen del EGFR y en donde se expresa la version truncada del receptor del EGFR de2-7, siendo utiles en el diagnostico y tratamiento del cancer. Tambien se refiere a un metodo para preparar dicho anticuerpo. It refers to an isolated anti-Epidermal Growth Factor Receptor (EGFR) antibody, which comprises a heavy chain variable region comprising the amino acid sequence SEQ ID No. 22 and a light chain variable region comprising the amino acid sequence SEQ ID No. 27, as well as a detectable or functional label, which is a covalently linked drug and an isolated nucleic acid that encodes it. Said antibody binds to EGFR in tumors that contain amplifications of the EGFR gene and where the truncated version of the EGFR receptor de2-7 is expressed, being useful in the diagnosis and treatment of cancer. It also refers to a method for preparing said antibody.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Białka swoiście wiążące i ich zastosowanie

Proteínas de ligação específica e suas utilizações

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild- type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID Nos: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

Egf receptor epitope peptides and uses thereof

The present invention relates generally to growth factor receptor epitope peptides, particularly EGF family receptor epitope peptides. The invention also relates to the use of the receptor peptides in generating antibodies which have anti-tumor or anti-cancer activity or in stimulating an immunological response. The invention further relates to antibodies specifically directed against the receptor peptides. Methods for generating an immune response and for treatment of tumors and cancer are also provided.

BINDING PROTEINS TO THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)

Se refiere a miembros de union especificos, particularmente anticuerpos y fragmentos de estos, que se unen al receptor del factor de crecimiento epidermico (EGFR) amplificado y a la version truncada del EGFR de 2-7. En particular, el epitope reconocido por los miembros de union especificos, particularmente los anticuerpos y los fragmentos de estos, se ve potenciado o es evidente al haber una modificacion post-traduccional aberrante. Estos miembros de union especificos son utiles en el diagnostico y el tratamiento del cancer. Los miembros de union de la presente invencion tambien pueden usarse en la terapia, en combinacion con agentes quimioterapeuticos o anticancerosos y/o con otros anticuerpos o fragmentos de estos It refers to specific binding members, particularly antibodies and fragments thereof, that bind to the amplified epidermal growth factor receptor (EGFR) and to the truncated version of EGFR of 2-7. In particular, the epitope recognized by specific binding members, particularly antibodies and fragments thereof, is enhanced or evident by aberrant post-translational modification. These specific union members are helpful in the diagnosis and treatment of cancer. The binding members of the present invention can also be used in therapy, in combination with chemotherapeutic or anticancer agents and / or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

Discloses an immunoconjugate comprising an isolated anti-Epidermal Growth Factor Receptor (EGFR) antibody attached to a cytotoxic agent, wherein the anti-EGFR antibody is an IgG1 isotype, comprises a heavy chain comprising a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 164, and comprises a kappa light chain comprising a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 166, wherein the antibody is expressed in a mammalian cell, wherein the sequences are as defined in the complete specification.

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

Discloses use of an isolated anti-Epidermal Growth Factor Receptor (EGFR) IgG1 antibody conjugated to a cytotoxic agent, in the preparation of a medicament for treating cancer in a subject, wherein said antibody comprises a heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 164, and comprises a light chain variable region comprising the amino acid sequence set forth in SEQ ID NO: 166, and wherein said antibody further comprises a kappa light chain constant region, wherein the sequences are as defined in the complete specification.

Specific binding proteins and uses thereof

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Specific binding proteins and uses thereof

SPECIFIC BINDING PROTEINS AND THEIR USES

SE REFIERE A UN ANTICUERPO AISLADO QUE PUEDE UNIRSE AL EGFR EN TUMORES QUE CONTIENEN AMPLIFICACIONES DEL GEN DEL EGFR Y EN TUMORES DONDE SE EXPRESA LA VERSION TRUNCADA DEL RECEPTOR DEL EGFR DE 2-7, DONDE LAS CELULAS DE DICHOS TUMORES CONTIENE MULTIPLES COPIAS DEL GEN DEL EGFR, DICHO ANTICUERPO COMPRENDE: i) UNA REGION VARIABLE DE LA CADENA PESADA QUE CORRESPONDE A LOS DOMINIOS DE UNION QUE TIENEN SECUENCIAS DE AMINOACIDOS DE SEQ ID Nº 130, 131 Y 132; E ii) UNA REGION VARIABLE DE LA CADENA LIVIANA QUE CORRESPONDE A LOS DOMINIOS DE UNION QUE TIENEN SECUENCIAS DE AMINOACIDOS DE SEQ ID Nº 135, 136 Y 137. EN DONDE EL ANTICUERPO AISLADO ES PEGILADO Y CONTIENE UNA RADIOMARCA, ADEMAS TOMA LA FORMA DE UN ANTICUERPO F(ab')2, UN FRAGMENTO scFv, UN DIACUERPO, UN TRIACUERPO O UN TETRACUERPO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE GLIOBLASTOMA, MEDULOBLASTOMA, MENINGIOMA, ASTROCITOMA REFERS TO AN ISOLATED ANTIBODY THAT CAN BIND TO EGFR IN TUMORS CONTAINING AMPLIFICATIONS OF THE EGFR GENE AND IN TUMORS WHERE THE TRUNCATED VERSION OF THE 2-7 EGFR RECEPTOR IS EXPRESSED, WHERE THE CELLS OF SUCH TUMORS CONTAIN MULTI COPIES OF THE GENE EGFR, SAID ANTIBODY INCLUDES: i) A VARIABLE REGION OF THE HEAVY CHAIN THAT CORRESPONDS TO THE UNION DOMAINS THAT HAVE SEQ ID NO. 130, 131 AND 132 AMINO ACID SEQUENCES; AND ii) A VARIABLE REGION OF THE LIGHT CHAIN THAT CORRESPONDS TO THE UNION DOMAINS THAT HAVE AMINO ACID SEQUENCES OF SEQ ID No. 135, 136 AND 137. WHERE THE ISOLATED ANTIBODY IS STICKED AND CONTAINS A RADIOMARK, ALSO TAKES THE FORM OF A ANTIBODY F (ab ') 2, A scFv FRAGMENT, A DIACBODY, A TRIACODY, OR A TETRABODY. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT IS USEFUL IN THE TREATMENT OF GLIOBLASTOMA, MEDULOBLASTOMA, MENINGIOMA, ASTROCYTOMA

Specific binding proteins and uses thereof

Specific binding proteins and their use

Anticuerpo anti-receptor de factor de crecimiento epidérmico (EGFR) aislado para utilizar en el tratamiento de un cáncer residente en el cerebro en un mamífero, en el que el cáncer residente en el cerebro se selecciona del grupo que consiste en glioblastoma, meduloblastoma, meningioma, astrocitoma neoplásica y malformación arteriovenosa neoplásica, y en el que el anticuerpo comprende una región variable de cadena pesada que comprende la secuencia de aminoácidos establecida en la SEQ ID NO: 164, comprende una región variable de cadena ligera que comprende la secuencia de aminoácidos establecida en la SEQ ID NO: 166 y se conjuga a un agente seleccionado del grupo que consiste en un agente de ablación química, toxina, inmunomodulador, citoquina, agente citotóxico, agente quimioterapéutico y fármaco. Anti-epidermal growth factor receptor (EGFR) antibody isolated for use in the treatment of a brain-resident cancer in a mammal, in which the brain-resident cancer is selected from the group consisting of glioblastoma, medulloblastoma, meningioma , neoplastic astrocytoma and neoplastic arteriovenous malformation, and wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence established in SEQ ID NO: 164, comprises a light chain variable region comprising the established amino acid sequence in SEQ ID NO: 166 and conjugated to an agent selected from the group consisting of a chemical ablation agent, toxin, immunomodulator, cytokine, cytotoxic agent, chemotherapeutic agent and drug.

Specific binding proteins and uses thereof

The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof,

Specific binding proteins and uses thereof

[0718] The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof. is enhanced or evident upon aberrant post--translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof. Figure 1