Methods of de-epitoping wheat proteins and use of same for the treatment of celiac disease

A method for identifying an epitope of a wheat T cell immunogen is provided. The method comprises identifying an epitope on the wheat T cell immunogen for the ability to bind a major histocompatibility complex (MHC) class II, thereby identifying the epitope of a wheat T cell immunogen.

RAPID ANTIMICROBIAL SUSCEPTIBILITY TESTING BASED ON A UNIQUE SPECTRAL INTENSITY RATIO ANALYSIS VIA SINGLE FLUORESCENCE MEMBRANE DYE STAINING AND FLOW CYTOMETRY

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

MEANS AND METHODS FOR DETECTING ANTIBIOTIC RESISTANT BACTERIA IN A SAMPLE

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample, comprising steps of: a. obtaining an absorption spectrum (AS) of said uncultured sample; b. acquiring the n dimensional volume boundaries for said specific bacteria; c. data processing said AS; i. noise reducing; ii. extracting m features from said entire AS; iii. dividing said AS into several segments according to said m features; iv. calculating m 1 features of each of said segment; and, d. detecting and/or identifying said specific bacteria if said m 1 features and/or said m features are within said n dimensional volume; wherein said bacteria is a antibiotics resistance bacteria.

RAPID ANTIBIOTIC SUSCEPTIBILITY TEST USING MEMBRANE FLUORESCENCE STAINING AND SPECTRAL INTENSITY RATIO IMPROVED BY FLOW CYTOMETRY DEAD TO LIVE POPULATION RATIO

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

FLEXIBLE CONSTRAINED LINER FOR HIP PROSTHESIS

Provided are improved hip prosthetic devices that reduce the risk of hip dislocation upon performing artificial hip replacement. The improved hip prosthetic devices comprise a flexible bumper configured to extend from the acetabular component and prevent contact between the femoral neck and the acetabular component. The bumper may be an acetabular capsule inserted in collaboration with a standard hip prosthetic device, and attached to a standard acetabular liner. The capsule has a bumper region that cushions contact between the femoral neck and the acetabular component, thereby preventing impingement and dislocation, both common in patients in which known hip prosthetic devices are used. Alternatively, an improved acetabular liner comprises an integral bumper which prevents impingement of the femoral neck and acetabular components, thereby reducing dislocation risk and securing the femoral head within the acetabular liner.

MEANS AND METHODS FOR DETECTING BACTERIA IN A SAMPLE

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps se lected inter alia from (a) obtaining an absorption spectrum (AS) of said unc ultured sample; (b) acquiring the n dimensional volume boundaries for said s pecific bacteria; (c) data processing said AS; and, (d) detecting and/or ide ntifying said specific bacteria if said m1 statistical correlation and/or sa id m features are within said n dimensional volume.

Microscopy for Rapid Antibiotic Susceptibility Test Using Membrane Fluorescence Staining and Spectral Intensity Ratio

Single dye fluorescent staining, microscopic imaging, and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). By use of microscopic imaging, such as confocal imaging, this allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections, including those that eventually lead to sepsis. 1. A method of determining a minimum inhibitory concentration (MIC) of one or more bacteria in a sample comprising:preparing a plurality of bacterial suspensions in a plurality of receptacles;adding different amounts of an antimicrobial agent to two or more of the plurality of bacterial suspensions, thereby creating a plurality of suspensions comprising a combination of bacteria and an antimicrobial agents;incubating the plurality of suspensions comprising a combination of bacteria and an antimicrobial agent at a suitable temperature for a suitable period of time to produce a plurality of incubated suspensions comprising a combination of bacteria and an antimicrobial agent;adding a single membrane-associated dye to the plurality of incubated suspensions;illuminating the incubated suspensions comprising the dye with a light at a one or more excitation wavelength for the dye;obtaining microscopic images of the incubated suspensions comprising the dye at two emission wavelengths of the dye;determining, with at least one processor, an intensity of emitted light at the two emission wavelengths of the dye for individual bacterial cells in each image;determining, with the at least one processor, an MIC for bacteria in the sample based upon the relative intensity of emitted light at the two emission wavelengths of the dye for individual bacterial cells in each image.2. The method of claim ...

Means and methods for detecting bacteria in a sample

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

System and method for monitoring water transmission of UV light in disinfection systems

Some demonstrative embodiments of the invention include a system and a method for disinfection of a liquid including monitoring the disinfection process. The system may include a short-path light detector located in proximity to the illumination source to detect the intensity of light emitted from the illumination source at a short distance from the source. The system may include at least one additional long-path light detector located in proximity to the transparent walls of the conduit of liquid to be disinfected that detects light emitted from the illumination source after propagating in the liquid and exiting through the transparent walls.

Means and methods for detecting bacteria in a sample

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

Means and Methods for Rapid Droplet, Aerosols and Swab Infection Analysis

The present invention provides an optical unit () adapted to accommodate a sample and to enable optical detection of infection within said sample; said optical unit comprising a body (); said body is characterized by a distal end and a proximal end interconnected via a main longitudinal axis; said body () comprising at least one mirror () coupled to said distal end; wherein said mirror () having a proximal and distal surfaces; said proximal surface faces said mask; said proximal surface is adapted to accommodate said sample. 178-. (canceled)7932010. An optical unit () adapted to accommodate a sample and to enable optical detection of infection within said sample; said optical unit comprising a body (); wherein the internal surface of said body is highly reflected and has mirror-like optical properties; further wherein internal volume of said body is adapted to accommodate said sample.80320105050. The optical unit () according to claim 79 , wherein said internal surface of said body () comprising at least one mirror (); wherein said mirror () having at least one proximal surface and at least one distal surface; wherein said at least one proximal surface is adapted to accommodate said sample.81320. An optical unit () adapted to accommodate a sample and to enable optical detection of infection within said sample; wherein said optical unit is a mirror upon which said sample is placed.82320. The optical unit () according to claim 80 , wherein said proximal surface has a surface chosen from a group comprising of planar surface claim 80 , concave claim 80 , surface claim 80 , convex surface claim 80 , hyperbolic claim 80 , parabolic claim 80 , conal shape.83320. The optical unit () according to claim 81 , wherein the surface of said mirror is selected from a group comprising of planar surface claim 81 , concave claim 81 , surface claim 81 , convex surface claim 81 , hyperbolic claim 81 , parabolic claim 81 , conal shape.84320. The optical unit () according to claim 80 , ...

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

MEANS AND METHODS FOR DETECTING BACTERIA IN A SAMPLE

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

MEANS AND METHODS FOR DETECTING ANTIBIOTIC RESISTANT BACTERIA IN A SAMPLE

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample, comprising steps of: a. obtaining an absorption spectrum (AS) of said uncultured sample; b. acquiring the n dimensional volume boundaries for said specific bacteria; c. data processing said AS; i. noise reducing; ii. extracting m features from said entire AS; iii. dividing said AS into several segments according to said m features; iv. calculating m1 features of each of said segment; and, d. detecting and/or identifying said specific bacteria if said m1 features and/or said m features are within said n dimensional volume; wherein said bacteria is a antibiotics resistance bacteria.

Rapid Antibiotic Susceptibility Test Using Membrane Fluorescence Staining and Spectral Intensity Ratio Improved by Flow Cytometry Dead to Live Population Ratio

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis. 1. A method for determining a minimum inhibitory concentration of one or more bacteria in a sample comprising the steps of:a. determining the gram-type of the one or more bacteria in the sampleb. preparing a plurality of bacterial suspensions in a plurality of receptacles,c. adding to step b. varying concentrations of an antimicrobial agent, thereby creating a plurality of suspensions comprising a combination of bacteria and antimicrobial agent,d. incubating the plurality of suspensions comprising a combination of bacteria and antimicrobial agent of step c. at a suitable temperature for a suitable period of time, thereby creating a plurality of incubated suspensions comprising a combination of bacteria and antimicrobial agent,e. adding to the suspensions of step d. a single membrane-associated dye,f. illuminating the suspensions of step e. with a light at a one or more excitation wavelength,g. performing a light scatter gating analysis to discriminate between bacteria and suspension clutter.h. measuring intensity of emitted light at two emission wavelengths of individual bacterial cells in each suspension,i. determining the spectral intensity ratios based upon step h.,j. determining from the respective bacterial suspension dead/live (D/L) ratios of bacterial cells based upon step h. of each suspension,k. calculating SDL values by taking the spectral intensity ratios of step i. and multiplying them with the D/L ratios of step j., andl. determining the minimum ...

System and method for monitoring water transmission of UV light in disinfection systems

Some demonstrative embodiments of the invention include a system and a method for disinfection of a liquid including monitoring the disinfection process. The system may include a short-path light detector located in proximity to the illumination source to detect the intensity of light emitted from the illumination source at a short distance from the source. The system may include at least one additional long-path light detector located in proximity to the transparent walls of the conduit of liquid to be disinfected that detects light emitted from the illumination source after propagating in the liquid and exiting through the transparent walls.

Wearable glucometer configurations

Apparatus for assaying an analyte in a patient's body comprising: at least one sensor unit mountable to a region of the patient's skin comprising at least one light source that illuminates a tissue region below the skin with light that generates photoacoustic waves therein and at least one acoustic transducer that generates signals responsive to the photoacoustic waves; and a control unit configured to be mounted to a different part of the body and comprising a controller for controlling the at least one light source and at least one acoustic transducer and receiving the signals generated by the at least one acoustic transducer.

Means and Methods for Detecting Bacteria in an Aerosol Sample

This disclosure provides a method for detecting and/or identifying uncultured bacteria. The sample is an aerosol sample selected from a group consisting of cough, sneeze, saliva, mucus, bile, urine, vaginal secretions, middle ear aspirate, pus, pleural effusions, synovial fluid, abscesses, cavity swabs, serum, blood and spinal fluid. The method comprises obtaining absorption spectra (AS) of the sample, extracting and processing the acquired data, thereby detecting and/or identifying the bacteria.

Rapid antibiotic susceptibility test using membrane fluorescence staining and spectral intensity ratio improved by flow cytometry dead to live population ratio

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

Rapid Antimicrobial Susceptibility Testing Based on a Unique Spectral Intensity Ratio Analysis via Single Fluorescence Membrane Dye Staining and Flow Cytometry

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis. 1. A method for determining a minimum inhibitory concentration of one or more bacteria in a sample comprising the steps of:a. preparing a plurality of bacterial suspensions in a plurality of receptacles,b. adding to step a. varying concentrations of an antimicrobial agent, thereby creating a plurality of suspensions comprising a combination of bacteria and antimicrobial agent,c. incubating the plurality of suspensions comprising a combination of bacteria and antimicrobial agent of step b. at a suitable temperature for a suitable period of time, thereby creating a plurality of incubated suspensions comprising a combination of bacteria and antimicrobial agent,d. adding to the suspensions of step c. a single membrane-associated dye,e. illuminating the suspensions of step d. with an incident light at a one or more excitation wavelength,f. measuring intensity of emitted light at two emission wavelengths of each suspension,g. determining the spectral intensity ratios based upon step f. of each suspension, andh. determining the minimum inhibitory concentration based upon step g. by determining the spectral intensity ratio (SIR) as a function of the antimicrobial concentration.3. The method of claim 1 , wherein the single membrane-associated dye is a styryl dye or a cyanine dye.4. The method of claim 1 , wherein the single membrane-associated dye is FM 1-43.5. The method of claim 1 , wherein the one excitation wavelength is a wavelength selected between the range of 360 nm ...

Rapid Antimicrobial Susceptibility Testing Based on a Unique Spectral Intensity Ratio Analysis via Single Fluorescence Membrane Dye Staining and Flow Cytometry

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis. 125.-. (canceled)26. A method for treating a patient suffering from a bacterial infection comprising the steps of: i. preparing a plurality of bacterial suspensions in a plurality of receptacles;', 'ii. adding to each of the plurality of bacterial suspensions different concentrations of an antimicrobial agent, thereby creating a plurality of suspensions comprising a combination of bacteria and the antimicrobial agent;', 'iii. incubating the plurality of suspensions comprising the combination of bacteria and the antimicrobial agent at a suitable temperature for a suitable period of time, thereby creating a plurality of incubated suspensions comprising a combination of bacteria and antimicrobial agent;', 'iv. adding to the suspensions of step iii. a single membrane-associated dye;', 'v. illuminating in a cytometer the suspensions of step iv. with an incident light at an excitation wavelength for the dye;', 'vi. measuring in the cytometer, intensity of emitted light at two emission wavelengths for the dye of each suspension; and', 'vii. using data obtained from the cytometer of the measurement of the intensity of emitted light at two emission wavelengths of each suspension, determining a spectral intensity ratio (SIR) based upon step vi. of each suspension, and determining the minimum inhibitory concentration of the antimicrobial agent for the bacteria by determining the SIR as a function of the antimicrobial concentration; and, 'obtaining a minimum inhibitory ...

METHODS OF DE-EPITOPING WHEAT PROTEINS AND USE OF SAME FOR THE TREATMENT OF CELIAC DISEASE

A method for identifying an epitope of a wheat T cell immunogen is provided. The method comprises identifying an epitope on the wheat T cell immunogen for the ability to bind a major histocompatibility complex (MHC) class II, thereby identifying the epitope of a wheat T cell immunogen. 1. A method for identifying an epitope of a wheat T cell immunogen , the method comprising identifying an epitope on the wheat T cell immunogen for the ability to bind a major histocompatibility complex (MHC) class II , thereby identifying the epitope of a wheat T cell immunogen.2. A method for de-epitoping a wheat polypeptide , the method comprising mutating one or more amino acid residues of a celiac-associated epitope on the wheat polypeptide to generate a de-epitoped polypeptide having one or more mutation in said celiac-associated epitope , thereby de-epitoping the wheat polypeptide.3. The method of claim 1 , wherein said epitope is a celiac-associated epitope.4. The method of claim 2 , wherein said mutating one or more amino acids does not reduce the allergenicity of said wheat polypeptide.5. The method of claim 2 , wherein said wheat polypeptide is a glutenin or a gliadin.6. (canceled)7. The method of claim 2 , further comprising identifying an epitope on the wheat polypeptide for the ability to bind a major histocompatibility complex (MHC) class II wherein said predicting is performed prior to said mutating.8. (canceled)9. The method of claim 2 , further comprising identifying an epitope on the wheat polypeptide from the amino acid sequence of antigen binding regions of T cell receptors (TCRs) which bind to said wheat polypeptide.10. (canceled)11. The method of claim 1 , wherein said identifying is by computationally predicting the epitope and is optionally performed using a machine-learning algorithm trained to recognize residue pairing preferences on a dataset of MHC II-peptide complexes.12. The method of claim 1 , wherein said identifying is by computationally predicting ...

Wearable glucometer configurations

Apparatus for assaying an analyte in a patient's body comprising: at least one sensor unit mountable to a region of the patient's skin comprising at least one light source that illuminates a tissue region below the skin with light that generates photoacoustic waves therein and at least one acoustic transducer that generates signals responsive to the photoacoustic waves; and a control unit configured to be mounted to a different part of the body and comprising a controller for controlling the at least one light source and at least one acoustic transducer and receiving the signals generated by the at least one acoustic transducer.

Modified high molecular weight glutenin subunit and uses thereof

A de-epitoped high molecular weight (HMW) glutenin is provided. Methods of generating same, and uses thereof are also provided.

Flexible constrained liner for hip prosthesis

Provided are improved hip prosthetic devices that reduce the risk of hip dislocation upon performing artificial hip replacement. The improved hip prosthetic devices comprise a flexible bumper configured to extend from the acetabular component and prevent contact between the femoral neck and the acetabular component. The bumper may be an acetabular capsule inserted in collaboration with a standard hip prosthetic device, and attached to a standard acetabular liner. The capsule has a bumper region that cushions contact between the femoral neck and the acetabular component, thereby preventing impingement and dislocation, both common in patients in which known hip prosthetic devices are used. Alternatively, an improved acetabular liner comprises an integral bumper which prevents impingement of the femoral neck and acetabular components, thereby reducing dislocation risk and securing the femoral head within the acetabular liner.

Means and methods for detecting bacteria in a sample

The present invention provides a method for detecting and/or identifying specific bacteria within an uncultured sample. The method comprises steps selected inter alia from (a) obtaining an absorption spectrum (AS) of said uncultured sample; (b) acquiring the n dimensional volume boundaries for said specific bacteria; (c) data processing said AS; and, (d) detecting and/or identifying said specific bacteria if said m1 statistical correlation and/or said m features are within said n dimensional volume.

Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage

An isolated polypeptide comprising the amino acid sequence of serum paraoxonase (PON1) having catalytic efficiency of k cat /K M ≈10 6 M -1 min -1 for a nerve-agent substrate.

Hypoallergenic peanut allergens, production and use thereof

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.

Modified low molecular weight glutenin subunit and uses thereof

A de-epitoped low molecular weight glutenin subunits (LMW-GS) is provided. Methods of generating same and uses thereof are also provided. A de-epitoped LMW-GS may be beneficial for a subject suffering from gluten sensitivities, such as a celiac disease patient. A de-epitoped LMW-GS may be comprised in food or beverage products such as bread, cake, cookie, noodle, pasta, or pizza.

Modified high molecular weight glutenin subunit and uses thereof

A de-epitoped high molecular weight (HMW) glutenin is provided. Methods of generating same, and uses thereof are also provided.

Isolated pon1 polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage

An isolated polypeptide comprising the amino acid sequence of serum paraoxonase (PON1) having catalytic efficiency of k cat /K M ≈10 6 M -1 min -1 for a nerve-agent substrate.

Modified high molecular weight glutenin subunit and uses thereof

A de-epitoped high molecular weight (HMW) glutenin is provided. Methods of generating same, and uses thereof are also provided.

Modified low molecular weight glutenin subunit and uses thereof

A de-epitoped low molecular weight glutenin subunits (LMW-GS) is provided. Methods of generating same and uses thereof are also provided. A de-epitoped LMW-GS may be beneficial for a subject suffering from gluten sensitivities, such as a celiac disease patient. A de-epitoped LMW-GS may be comprised in food or beverage products such as bread, cake, cookie, noodle, pasta, or pizza.

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

Modified low molecular weight glutenin subunit and uses thereof

A de-epitoped low molecular weight glutenin subunits (LMW-GS) is provided. Methods of generating same and uses thereof are also provided. A de-epitoped LMW-GS may be beneficial for a subject suffering from gluten sensitivities, such as a celiac disease patient. A de-epitoped LMW-GS may be comprised in food or beverage products such as bread, cake, cookie, noodle, pasta, or pizza.

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.

Rapid antimicrobial susceptibility testing based on a unique spectral intensity ratio analysis via single fluorescence membrane dye staining and flow cytometry

Compositions and methods for inducing desensitization to peanuts

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 6 variants wherein at least one epitope recognized by anti-Ara h 6 antibodies has been modified, thereby having reduced or abolished antibody binding to the peanut allergen. These peanut allergen variants are hypoallergenic but maintain their immunogenicity and may be used in methods of treating subjects allergic to peanuts and reducing the severity of their allergy.

Hypoallergenic peanut allergens, production and use thereof

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.

Hypoallergenic peanut allergens, production and use thereof

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.

Hypoallergenic peanut allergens, production and use thereof

In one embodiment, the present disclosure provides a combination of recombinant Ara h 1 and Ara h 2 variant polypeptides lacking at least one epitope recognized by anti-Ara h 1 antibodies and anti-Ara h 2 antibodies, respectively, thereby having reduced or abolished antibody binding to the peanut allergen. These peanut allergen variants may be used in methods of treating subjects allergic to peanuts and reducing the severity of their allergy.

Modified low molecular weight glutenin subunit and uses thereof

A de-epitoped low molecular weight glutenin subunits (LMW-GS) is provided. Methods of generating same and uses thereof are also provided. A de-epitoped LMW-GS may be beneficial for a subject suffering from gluten sensitivities, such as a celiac disease patient. A de-epitoped LMW-GS may be comprised in food or beverage products such as bread, cake, cookie, noodle, pasta, or pizza.

Hypoallergenic peanut allergens, production and use thereof

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.

Means and methods for rapid droplet, aerosols and swab infection analysis

The present invention provides an optical unit (320) adapted to accommodate a sample and to enable optical detection of infection within said sample; said optical unit comprising a body (100); said body is characterized by a distal end and a proximal end interconnected via a main longitudinal axis; said body (100) comprising at least one mirror (50) coupled to said distal end; wherein said mirror (50) having a proximal and distal surfaces; said proximal surface faces said mask; said proximal surface is adapted to accommodate said sample.